The invention discloses sour and hot sweet potato petioles. The sour and hot sweet potato petioles are prepared from sweet potato petioles, sweet potato leaves, trberculate speranskia herb, herba lysimachiae, herba hyperici japonici, dioscorea nipponica makino subsp. rosthornii (prain et burkill) C.T.Ting, roxburgh peristrophe herb, silene aprica, beckmannia syzigachne, Sri Lanka pouzolzia herb, Indian adenosma, hydrocotyle vulgaris, soybean oligosaccharides, lactic acid bacteria, salt, spices and compound enzymes. The sour and hot sweet potato petioles are rich in nutrition, rich in fragrance, sour, hot, crispy and bright green in color and luster, deep processing ways of the hot sweet potato petioles are increased, and the economic income is increased by 15.3%; the sweet potato petioles are dried in a staged mode, the nutrition is retained, the raw astringency flavor is removed, the texture is soft, fermentation is convenient, and the crispy mouthfeel of the finished product is improved; after traditional Chinese medicine are dried through microwave, a scorched flavor is generated, the bitter taste is diluted, fermentation is conducted through the lactic acid bacteria, macromolecular substance decomposition is promoted, nutritional substances are fully mixed, the nutritional and health-care functions are enhanced, and the sour and hot sweet potato petiole can remove toxicity, main beauty, lose weight, slim a body, prevent and treat decayed teeth, delay senescence, protect heart and cerebral vessels, enhance immunity and inhibit and resist cancers and can be eaten safely by all people.