115 results about "Antipyretic Effect" patented technology

The invention belongs to the medical technical field and discloses the application of high-purity in the preparation of antibacterial medicine, antiviral medicine and other medicines. The invention proves the antipyretic, anti-inflammation, immunity enhancement, antibacterial and anti-virus effects of high-purity forsythiaside through the following experiments: (1) the experiment that high-purity forsythiaside has antipyretic effect on fever rats; (2) the experiment that high-purity forsythiaside inhibits xylene-induced mice ear edema, xylene-reduced capillary permeability of mice; (3) the experiment that high-purity forsythiaside increases carbon clearance ability of mice and increases the lymphocyte transformation rate; (4) the experiment that high-purity forsythiaside has vitro anti-influenza A type virus effect and in-vivo anti-respiratory syncytial virus effect; (5) the experiment that high-purity forsythiaside has vitro inhibition effects on beta-hemolytic streptococcus, staphylococcus aureus, streptococcus viridans and staphylococcus epidermidis.

The present invention is directed to pharmaceutical compositions containing (a) a dosage of a non-steroidal anti-inflammatory drug (NSAID) effective to induce analgesia an anti-inflammatory effect, or an anti-pyretic effect and (b) a beta-cyclodextrin compound; wherein the dosage of the NSAID compound is less than the minimum approved dose for the route of administration. Additionally, the present invention is directed to methods for treating a mammal in need of an analgesic, an anti-inflammatory, or an anti-pyretic agent comprising administering the pharmaceutical composition of the present invention.

The invention provides a solar parasol and belongs to the technical field of solar energy. The solar parasol includes an umbrella body, a base and a pillar, the pillar is installed on the base, the umbrella body is connected to the upper end of the pillar, a number of solar photovoltaic modules are arranged on the outside of the umbrella body, a battery for power storage is arranged in the base, and a The cooling plate has an air guide port on the outer end of the pillar, and the cooling sheet generates cold air, which is output through the air guide port. The air guide port is connected with an air guide pipe, and a small fan is installed in the air guide pipe. Platform, the top of the umbrella body has a wind cup type anemometer to detect the wind force, the solar photovoltaic module converts the solar energy into electric energy and stores it directly in the battery, the umbrella body is a structure that can be accommodated, the umbrella body includes a skeleton and an umbrella surface, and the umbrella surface is accommodated by it The creases are divided into several umbrella pieces, and the solar photovoltaic modules correspond to one umbrella piece one by one. The invention not only has many functions, but also further improves the cooling effect and antipyretic effect.

The invention relates to an auxiliary article in medical treatment, an antipyretic paste, which is mainly prepared from the following raw material of (wt%), peppermint 0.1-15, ethanol 1-30, glycerol 1-30, borneol 0.1-15, and spreadable gel base or ointment base in balancing amount. The antipyretic paste made from the above formula can be applied on the skin surface of a pyretic patient to conduct auxiliary antipyretic treatment under physical and medical dual antipyretic effect. The inventive antipyretic paste has physical and medical dual antipyretic effect, resulting in better and safer antipyretic effect, and has no toxic and adverse effects.

The invention relates to a traditional Chinese medicine composition for treating cold, a preparation method thereof and a detection method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises ephedra herb, almond, etc., and has favorable antipyretic effects.

The invention relates to a method for preparing Chinese medical burn antipyretic gauze, which is applied to the treatment on burn in various degrees. Chinese medicines are used as raw materials in the method and the method comprises the following steps of: A. Chinese medicine selection, B. Chinese medicine pretreatment, C. Chinese medicine oil immersion, D. medicine oil purification, E. medicine gauze preparation, and F. application of the burn antipyretic gauze. The invention has the advantages that the burn antipyretic gauze can accelerate the cell growth of the wounded burn surface for forming fiber phloem islands to be fused into the covering skin, the effects of preventing haemostasis, softening scabs, reducing swelling, alleviating pain, removing inflammation and draining the fluid can be realized, the medical burn antipyretic gauze is applicable to the burn and the scald in different degrees, the application method is convenient, the pain of patients during dressing change can be reduced, the cure time is short, and the scar can not be formed. The medical burn antipyretic gauze has the advantages of higher antipyretic effect, higher oxidation resistance, higher stability and higher applicability.

The present invention is the recipe and preparation process of medicine Yujin preparation, and is especially emulsion type Yujin nose drops, which have the same antipyretic effect as the Yujin injection and may be used to replace Yujin injection clinically.

The invention discloses a temperature sensitive gel sustained-release oral agent with a paracetamol, and relates to the technical field of pharmaceutic preparation. A carrier in the oral agent provided by the invention convenient for feeding includes paracetamol serving as an active ingredient and xyloglucan or a mixture of xyloglucan and another polysaccharide, wherein another polysaccharide is pectin, chitosan, algal polysaccharides or gellan gum. According to the invention, a polymer three-dimensional gel net structure formed by the polysaccharide is used for establishing a sustained-release system combined with clinical pathology so as to obtain the temperature sensitive gel sustained-release oral agent with the paracetamol; the temperature range for sol-gel change is 35-37 DEG C which is close to body temperature, so the oral agent is particularly suitable for old people, infants and people who have difficulty in swallowing, and has obvious efficacy. The temperature sensitive gel sustained-release oral agent disclosed by the invention has obvious analgesic and antipyretic effects, is convenient for administration and free of toxic and side effects, and the drug action can last for a long time.

The invention discloses efficient heat-transfer antipyretic patch. The efficient heat-transfer antipyretic patch is characterized by comprising a back lining layer, a gel layer and an isolation layer,the gel layer is arranged between the back lining layer and the isolating layer, the gel layer is composed of gel, modified porous graphene and antipyretic drug according to a mass ratio of 20:1-5:1-5. Modified graphene and hydrogel are mixed, the antipyretic drug is loaded, modified graphene has many holes, and loading space for the antipyretic drug can be provided; heat conductivity of modifiedgraphene is far better than high macromolecular hydrogel, so that higher heat transfer efficiency of the antipyretic patch generally is realized, action efficiency of the antipyretic drug is ensured,and antipyretic effect is improved.

Disclosed is a dendrobium stem hydrating mask. The dendrobium stem hydrating mask is prepared from, 20-30 parts of dendrobium stem powder, 20-30 parts of a dendrobium stem extracting solution, 5-10 parts of amino acid, 20-30 parts of bee milk and 30-50 parts of water. The dendrobium stem powder and the dendrobium stem extracting solution are adopted; due to the fact that dendrobium stems contain abundant dendrobine, the mask has the pain-relieving and antipyretic effects, has the moisturizing effect, and can make the skin fine and smooth when used for a long time, and the skin quality is effectively improved; the amino acid can completely penetrate through the epithelial cell, and has the biological activity; the bee milk can promote and enhance the life vitality of the epidermis cell, and cell metabolism is improved; the components are safe, raw materials are natural, rapid generation of skin collagen can be effectively promoted, deep moisturizing is achieved, elasticity is enhanced, cutin is softened, and the skin is firmer.

The invention relates to a synergetic compound analgin injection and a preparation method thereof. The injection comprises the following components by weight in 100 milliliters: 10 to 30g of analgin, 2 to 4g of antioxidant, 50 to 150mg of dexamethasone sodium phosphate, 0.05g of EDTA (ethylene diamine tetraacetic acid)-Na2, injection water filled until the amount reaches 100ml, and proper pH regulating agent, wherein the usage of the pH regulating agent is sufficient to regulate the pH value of the system to be between 5.5 and 6.5. The preparation method comprises the following steps of adding the EDTA-Na2, the antioxidant and the analgin into the injection water, stirring until the EDTA-Na2, the antioxidant and the analgin are completely dissolved to prepare liquid A; dissolving the dexamethasone sodium phosphate with trace injection water to prepare liquid B; adding the liquid B into the liquid A, uniformly stirring, continuously stirring for 20 minutes, regulating the pH value to be between 5.5 and 6.5, and fixing the volume to 100ml; filtering medicinal liquid, filling the filtrate into a bottle with a filling and sealing machine; and sterilizing for 30 minutes at a temperature of 115 DEG C and at a pressure of 0.2MPa, and cooling and outputting to obtain a finished product. The dexamethasone sodium phosphate is added into the injection reasonably and compatibly, so that the antipyretic effect is reinforced, and the function of anti-inflammation and anti-allergy are given at the same time. The synergetic compound analgin injection is wide in drug effect and convenient to use.

A mint tea yoghourt consists of the following raw materials in parts by weight: 200-300 parts of fresh milk, 2-3 parts of mint leaf, 3-5 parts of green tea, 1-2 parts of clove, 3-5 parts of olive leaf, 4-8 parts of olive, 5-10 parts of mulberry fruit, 10-15 parts of jackfruit, 5-10 parts of red bayberry, 2-5 parts of carragheenan, 1-5 parts of sodium citrate, 15-20 parts of white sugar, and 2-3 parts of lactobacillus bulgaricus and lactococcus thermophilus, with a ratio of lactobacillus bulgaricus to lactococcus thermophilus being 1:2-1. The mint tea yoghourt has a certain antipyretic effect, and the yoghourt is added with some fresh fruits which are benefit to human health.

The invention provides a pharmaceutical composition with fever relieving effect. The composition is prepared from the following bulk drugs: 1-2 parts of bupleurum volatile oil, 1-2 parts of bupleurum extract total saponin, and 8-12 parts of a Scutellaria baicalensis extract. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition of the invention fully improves the efficacy of bupleurum and Scutellaria baicalensis, reduces the toxicity of bupleurum; bupleurum volatile oil, bupleurum total saponins and baicalin of Scutellaria baicalensis are extracted respectively, and are finally prepared into an emulsion, which is non-toxic in certain dose and efficient and has target effect. Experiments prove that the emulsion is safe and can improve the drug efficacy.

The invention belongs to the field of medicine and pharmacology, and is Pharmaceuticals oral granule. The Aceclofenac granule is made by raw material drug aceclofenac, findings and disintegrant. The Aceclofenac granule is phenyl acetic acid non-steroidal anti-inflammatory agent. It has notable anti-inflammatory, analgesic and antipyretic effect. It applies to the treatment of various rheumatoid arthritis, atrophic arthritis, osteoarthritis and spondylitis. It is fit for pain and fever caused by various diseases, and the toxic and side effects is lower than other varieties. Aceclofenac has not granule in prior medicine market; it is innovative formula and benefit for absorbing drug to getting better curative effect and better taste. It is safe, reliable and new drug for treatment of acute, chronic pain and anti-inflammation.

The invention discloses a medicine composition for treating flu and a preparation method thereof. The medicine composition is mainly prepared from glycyrrhizic acid, baicalin, pseudoephedrine, taurine and other compounds. The invention has the advantages of simple medicine composition and exact curative effect; and animal experiments indicate that the medicine composition has strong inhibiting effect on influenza A virus and influenza B virus, and has the effects of killing various respiratory tract pathogenic bacteria to different degrees. The medicine composition has obvious and long-lasting antipyretic action and obviously relieves various cold symptoms, such as rhinorrhoea, snuffle, pains, cough and the like. The medicine composition has the action of synergy, can address both the symptoms and root causes against the causes and the symptoms of cold, and can obviously shorten the course of cold. The medicine composition can be made into any acceptable excipient in pharmaceutics.

The invention provides a medicine used for treating influenza, upper respiratory infection and viral pneumonia. The medicine is glycoprotein or a mixture of polysaccharide and protein or polypeptide or protein. The glycoprotein provided by the invention has a stabilization effect on body temperatures of endotoxin pyrogenic domestic rabbits, and has an obvious antipyretic effect; the medicine provided by the invention is used for treating the influenza, the upper respiratory infection and the viral pneumonia, and no symptoms of bronchitis, pneumonia and tuberculosis; the complication is 0; the toxin-free concentration of the medicine to Vero-E6 cells is 100 mu g / ml, and has an obvious inhibition effect on SARS viruses. The medicine provided by the invention has obvious pharmacologic actions on seven aspects of in-vitro virus resistance, in-vivo virus resistance, bacterium inhibition, inflammation resistance, antipyretic action, pain alleviation and immunologic function improvement; the medicine has the characteristics of safety, high efficiency and no side effect and has functions of preventing and treating respiratory system diseases, and broad-spectrum anti-virus, anti-inflammatory, anticoagulation, bacteria resisting, antipyretic and immunity adjusting functions.

The invention provides a chili sauce for good health and the production methods, and relates to the technical field of food processing. The methods include the following steps of material preparation,primary fermentation, desalination, secondary fermentation and mashing chilies. An extract made from a mixture of lotus leaves, saffron crocus and honeysuckles is added during the mashing chilies process. To prevent the putrefying bacteria from appearing, high concentrations of salt are added during the primary fermentation process. To prevent too much salty taste from affecting the flavor, the desalination and the low-salt secondary fermentation are adopted. To prevent nitrite from appearing, plant polyphenols are added during the high-salt fermentation and the low-salt fermentation. The materials have the advantages that the lotus leaves and the honeysuckles have an antipyretic effect, reducing the risk of people suffering fromthe excessive internal heat caused by eating chilies, and the saffron crocus can reduce the risk of women getting acne from eating chilies.

The invention provides a pharmaceutical composition for treating fever caused by unknown reasons. The pharmaceutical composition is a preparation prepared from the following crude drugs in parts by weight: 17-31 parts of sweet wormwood, 8-16 parts of radix bupleuri, 4-8 parts of mentha haplocalyx, 21-39 parts of turtle shell, 8-16 parts of radix rehmanniae recen, 7-13 parts of moutan bark, 8-16 parts of rhizoma anemarrhenae, 7-13 parts of rhizoma picrorhizae, 10-20 parts of massa medicata fermentata fujianensis, 12-24 parts of rice sprout, 12-24 parts of malt, 8-16 parts of hawthorn, 8-16 parts of immature bitter orange and 10-20 parts of radix cynanchi wilfordii. The pharmaceutical composition can be used for effectively eliminating or greatly alleviating fever symptom caused by unknown reasons, has a good antipyretic effect, and provides a new choice for clinical medication.

The invention discloses a health-care orange-snow pear wine. The health-care wine comprises 40-60% of orange, 40-70% of white wine or yellow wine, 20-40% of crystal sugar, 30-40% of snow pear, 10-15% of momordica grosvenori and 10-15% of honeysuckle. The health-care orange-snow pear wine has the effects of clearing away the liver heat and benefiting the gallbladder, soothing the liver heat and dredging Qi, stopping pains and removing swelling, nourishing Yin and moistening the dryness, nourishing the blood and benefiting the blood, and nourishing Yin and strengthening Yang, can promote appetite, helps digestion, has diuretic and antipyretic effects, helps the kidney to excrete uric acid and prevent gout, rheumatism, arthritis and the like, and helps to prevent cancers and is beneficial to health after long-term drinking.

The invention relates to an antipyretic-analgesic traditional Chinese medicine composition. Angelica sinensis extract and ligusticum wallichii extract serve as effective medicinal components, and theantipyretic-analgesic traditional Chinese medicine composition is jointly composed of the angelica sinensis extract, the ligusticum wallichii extract and auxiliary adding ingredients acceptable in medicine. The proportion by weight of raw-material crude medicine angelica sinensis to the proportion by weight of raw-material crude medicine ligusticum wallichii which are fairly used for the extract of the effective medicinal component angelica sinensis and the extract of the effective medicinal component ligusticum wallichii is (0.1-5):(0.2-10) respectively. The antipyretic-analgesic traditionalChinese medicine composition is suitable for fevers, and has the effect on fevers caused by multiple reasons, the antipyretic-analgesic traditional Chinese medicine composition has the good antipyretic effect, the antipyretic effect mechanism of the antipyretic-analgesic traditional Chinese medicine composition is different from that of an aspirin, and the antipyretic-analgesic traditional Chinesemedicine composition does not have toxic and side effects of the aspirin; the traditional Chinese medicine composition also has the obvious analgesic effect, the analgesic effect of the traditional Chinese medicine composition is obviously higher than that of ibuprofen, and the traditional Chinese medicine composition can be used for muscular stiffness caused by cold or courbature and arthralgiawhich are caused by other seasons, and has broad application prospects.

The invention provides a compound essential oil composition for a cold or fever,a preparation and a preparation method and an application thereof,and relates to the technical field of functional essential oil. The compound essential oil composition is mainly composed of Chinese thorowax root essential oil,Chinese parsnip root essential oil,notopterygium root essential oil,peppermint essential oil,herba schizonepetae essential oil,lavender essential oil and flos matricariae chamomillae essential oil,The compound essential oil composition prepared from the above components and patches prepared by the compound essential oil composition the cold or fever have the advantages of obvious antipyretic effect,fragrant smell,simple preparation and convenient use. Compared with the existing anti-feverand antipyretic western medicine,the composition has no toxicity and side effect,is green and healthy,and also avoids the side effect of oral administration,the bioavailability of transdermal absorption is greatly improved,and the problem that the existing anti-fever and antipyretic western medicine has large toxic and side effect,high cost,easy generation of drug resistance and inconvenient administration is effectively relieved.

A compound catmint oil soft capsule, which solves the problems that the existing catmint oil preparations are inconvenient to take, the content of active ingredients is lost due to volatilization of the catmint oil in the process of preparation and storage, and the curative effect of a single catmint oil preparation is not significant According to 1000 grains, it is composed of 50-500 grams of catmint oil, 50-300 grams of forsythia oil, 50-500 grams of vegetable volatile oil, 0-850 grams of soybean oil and capsule material. The advantage is that nepeta oil combined with forsythia oil and plant volatile oil enhances the antipyretic, antibacterial, anti-viral, anti-inflammatory, nasal opening and other effects of nepeta oil and has a good antipyretic effect on biological fever. The compound preparation composed of oil and forsythia oil has a synergistic effect, expands the antibacterial spectrum and has obvious antipyretic and anti-inflammatory effects, which is more effective than nepeta oil or forsythia oil alone, and has less toxic and side effects; The drug is stable, has high bioavailability, is safe to use, has a significant curative effect, and has a rapid curative effect, and is easy to take orally and carry.

The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition with an antipyretic effect and a preparation method and the application of the traditional Chinese medicine composition. According to the traditional Chinese medicine composition with the antipyretic effect, disclosed by the invention, the channel tropism, the property and the flavor of all traditional Chinese medicines are fully considered, and all the traditional Chinese medicines are in mutual cooperation and co-action according to a monarch, minister, assistant and guide matching relationship by selecting a proportion between every two traditional Chinese medicines, so that the antipyretic effect can be expressed.

The invention discloses a herba gueldenstaedtia ethanol extract, which is prepared from the following method that: herba gueldenstaedtia is taken and extracted with 70-95% V / V ethanol, and a solvent is recovered from the extract so as to obtain the herba gueldenstaedtia ethanol extract. The invention also discloses a herba gueldenstaedtia ethyl acetate extract, a herba gueldenstaedtia n-butanol extract, and uses of the extracts. The herba gueldenstaedtia extracts, i.e. the herba gueldenstaedtia ethanol extract, ethyl acetate extract and n-butanol extract, have a good antipyretic effect, can be used for treating the common cold, and fever and other symptoms caused by the common cold, and provide a new drug choice for the clinic.

The invention relates to veterinary anti-inflammation traditional Chinese medicine composition as well as a preparation method and an application thereof, and belongs to the technical field of veterinary drugs. The veterinary anti-inflammation traditional Chinese medicine composition is prepared from components in parts by weight as follows: 20 parts of gypsum fibrosum, 20 parts of radix salviae miltiorrhizae, 20 parts of flos lonicerae, 10 parts of rhizoma anemarrhenae, 15 parts of radix rehmanniae recens, 10 parts of cornu bubali and 5 parts of radix glycyrrhizae. The traditional Chinese medicine composition has good anti-inflammation, analgesic and antipyretic effects, can reduce level of PGE2 and NO in serum, promote SOD release and inhibit synthesis and release of proinflammatory cytokines to balance expression level of proinflammatory cytokines and anti-inflammation cytokines in the serum and inhibit excessive inflammatory response, thereby playing a protective role for the body.Meanwhile, the preparation process of the veterinary anti-inflammation traditional Chinese medicine composition is simple, easy to operate, low in cost and suitable for industrial production.

The invention provides a novel enol non-steroidal compound represented by a formula (I) or a a pharmaceutically acceptable salt, hydrate, solvate, polymorph, enantiomer or racemic mixture thereof, wherein m is 0 or 1; n is an integer from 0 to 6; R1 and R2 are independently hydrogen or C1-C6 alkyl or optionally substituted C1-C6 alkyl, halogen, acylamino, sulfonylamino, acyloxy or C(O)R', and R' is hydrogen, C1-C10 alkyl, C1-C10 alkenyl, C1-C10 alkoxy, aryl C1-C10 alkyl, halogen, acylamino, sulfonylamino or acyloxy; R3 or R4 is independently hydrogen or C1-C6 alkyl or optionally substituted C1-C6 alkyl; R5 or R6 is independently hydrogen, a sodium salt, a potassium salt, a magnesium salt, a calcium salt, an ammonium salt, a meglumine salt, a choline salt, or an amino acid salt. The compound has obvious anti-inflammatory, analgesic and antipyretic effects, and the bioavailability of the compound is obviously higher than that of meloxicam. The invention also provides a preparation methodof the compound, a pharmaceutical composition containing the compound, and pharmaceutical applications of the compound and the pharmaceutical composition.

The invention is a chromatographic separation purification method of paeonol. The method comprises the following steps: cell disruption, salting out, dialysis, selection column chromatography, column packing, sample loading on the column and elution drying. The technical scheme of the invention reduces the part of disappeared paeonol due to dissolving in hot steam in a traditional distillation method, also reaches temperature control of paeonol in the separation process, and effectively reduces decomposition of the organic matter paeonol in high temperature, so as to achieve separation and purification of the maximum amount of paeonol from the minimum amount of bark of peony. The paeonol has analgesic, anti-inflammatory, antipyretic and anti allergic reaction functions, obvious analgesic effect on pains, obvious inhibitory effect on inflammation, obvious antipyretic effect on body temperature raising, and inhibition effect on allergic reaction of II, III, IV types; and paeonol can inhibit the generation of oxygen free radicals in cells, and whiten the skin.

The invention discloses a method for preparing ionic liquid and application thereof, wherein the method for preparing the ionic liquid comprises the steps of mixing levobupivacaine and salicylic acidtype compounds with solvents so as to obtain a mixed solution; regulating the pH value of the mixed solution so as to obtain a solution after the pH value regulation; mixing L-tartaric acid with the solution after the pH value regulation; performing filtering so as to obtain a filtered solution; performing extraction treatment on the filtered solution so as to obtain an extracted solution; performing drying rotary evaporation treatment on the extracted solution so as to obtain the ionic liquid, wherein the ionic liquid contains levobupivacaine positive ions and salicylic acid type negative ions. The ionic liquid prepared by the method has hydrochloric acid of levobupivacaine and double functions of antipyretic effect and analgesia.

The invention relates to an antipyretic gel, which is prepared from the following raw materials in mass percentage: 20%-45% of ethanol, 2%-10% of propylene glycol, 5%-20% of menthol, 8%-15% of plant essential oil, Borneol 1%‑30%, Xanthan Gum 10%‑40%, Sodium Paraben 2%‑10%. The beneficial effects of the present invention are: adding rosemary can calm the nerves and refresh the mind while treating fever; the combination of menthol and plant essential oils has a remarkable antipyretic effect; adding a moisturizing agent deeply moisturizes the skin, The drug lasts longer; it also has the advantages of being safe and comfortable, cool and refreshing, convenient and quick.

The invention discloses an external use Chinese herbal medicine compound preparation for children fever, which comprises the raw materials according to parts by weight: 1-10 parts of mint, 1-15 parts of radix bupleuri, 1-15 parts of rhizoma anemarrhenae, 1-10 parts of scutellaria baicalensis, 1-15 parts of honeysuckle, 1-15 parts of lindley eupatorium herb, 1-15 parts of schizonepeta, 1-20 parts of dayflower, 1-10 parts of folium isatidis, and 1-3 parts of borneol. The invention also discloses a preparation method for the external use Chinese herbal medicine compound preparation, comprising preparation methods of adhesive plaster and Baboo cream. The external use Chinese herbal medicine compound preparation has small toxic or side effects and can be used for treatment of children fever; the external preparation has rapid antipyretic effect through transdermal drug delivery and has antibiosis and antivirus effects, and is convenient to dose, and children are easy to accept; and the Chinese traditional medicine preparation can be made into different forms according to clinical requirement, the preparation method is simple to operate, and the external preparation can be used for treatment of children fever and has good curative effects.