6results about How to "Good analgesic effect" patented technology

This invention provides a traditional Chinese medicine preparation for promoting blood circulation and relieving pain, and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from the following parts by weight of traditional Chinese medicine raw materials: 10-30 parts of Polygonatum sibiricum, 10-30 parts of Spatholobus suberectus, 10-30 parts of Curcuma longa, 5-20 parts of Sparganium stoloniferum, 5-20 parts of Areca catechu peel, 5-20 parts of Polygonum hydropiper, 5-20 parts of Rhizoma Scutellariae, 1-5 parts of Artemisia argyi, 5-20 parts of Solanum nigrum, 5-20 parts of Catechu, 10-30 parts of Scutellaria barbata, 5-20 parts of Aristolochia debilis, 10-30 parts of Astragalus membranaceus, and 5-20 parts of Artemisia argyi oil. The traditional Chinese medicine preparations described in this invention differ from those that typically enhance the efficacy of a single herb. Instead, they exhibit a synergistic relationship where one plus one equals more than two. The principal, assistant, adjuvant, and guide herbs complement each other, combining both tonifying and purging effects. This approach effectively promotes the dissipation of blood stasis, unblocks the flow of qi and blood in the meridians, eliminates local inflammation, and reduces swelling and pain. Simultaneously, it nourishes the tendons and bones, supports the body's vital energy, and enhances the body's ability to resist pathogens and repair damage. Thus, it comprehensively alleviates pain caused by various factors, achieving the goals of promoting blood circulation, removing blood stasis, clearing the meridians, reducing inflammation and swelling, and relieving pain.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for improving lung deficiency type primary dysmenorrhea and a preparation method and application thereof. The traditional Chinese medicine composition specifically comprises multiple traditional Chinese medicine components including rhizoma polygonati, Chinese yam, rhizoma smilacis glabrae, radix salviae miltiorrhizae, yam rhizome, codonopsis pilosula, radix ophiopogonis from Sichuan of China, exocarpium citri grandis, spina date seeds, radix bupleuri, radix clematidis, morinda officinalis, rhodiola rosea, peach kernels, caulis spatholobi, southern apricot kernels and prepared rehmannia roots. The composition effectively relieves pain and improves accompanying symptoms through multi-target synergistic effects of promoting blood circulation to remove blood stasis, reinforcing qi and nourishing lung, warming kidney and strengthening spleen, regulating qi and relieving pain and the like. The formula follows the monarch, minister, assistant and guide theory of traditional Chinese medicine, is rigorous in compatibility, can comprehensively regulate qi, blood and viscera functions of a patient, is especially suitable for dysmenorrhea caused by deficiency of lung qi and unsmooth qi and blood circulation, and shows the advantages of overall treatment of traditional Chinese medicine. The preparation method is stable in process and easy to implement, and a safe and effective new choice for traditional Chinese medicine treatment is provided for lung deficiency type primary dysmenorrhea.

The invention belongs to the technical field of medicine, and particularly relates to a degradable sustained-release local anesthetic microsphere and a preparation method and application thereof.The degradable sustained-release local anesthetic microsphere comprises a drug core and a carrier shell wrapping the outer layer of the drug core, the drug core is a local anesthetic, and the carrier shell wraps the outer layer of the drug core. The carrier shell is a composite material of a modified polylactic acid-glycolic acid copolymer (PLGA) and a biocompatible auxiliary material. According to the invention, the modified PLGA is used as a carrier material, the hydrophilicity and the drug compatibility of the carrier are improved through PEG modification, the encapsulation efficiency (greater than or equal to 85%) and the drug loading capacity (10%-30%) of the local anesthetic are obviously improved, the drug waste is reduced, and the drug utilization rate is improved.

The present application provides a kind of purple spot sea anemone polypeptide toxin HC-G02 and its synthesis method, application, its amino acid sequence is APCSGCYYQVGNECVYDKLKC-NH2. Linear peptide HC-G02 is synthesized by adopting polypeptide solid-phase synthesis method, and the purity of linear peptide after purification reaches more than 95%. Purple spot sea anemone oxidized peptide HC-G02 (the connection mode of disulfide bond is C1-C3, C2-C4) is obtained by site-directed oxidation. The present application is found through hot plate experiment test that purple spot sea anemone oxidized peptide HC-G02 has good analgesic effect on physical pain of mouse, and the pain threshold of mouse intraperitoneal injection oxidized peptide HC-G02 is gradually increased in 30min, and the pain threshold reaches the highest in 120min after administration. The analgesic effect of oxidized peptide HC-G02 at 50mg / kg is equivalent to the analgesic effect of tramadol at the same concentration, and the analgesic time is prolonged.

The application provides an ultrasonic device and a control method for real-time modulation of ultrasonic parameters based on pain monitoring, comprising a controller, a treatment head and a signal acquisition assembly, the treatment head comprising a shell and an ultrasonic treatment transducer, the side of the shell facing the patient being provided with an acoustic window for emitting treatment ultrasonic waves to the skin surface, the controller calculating a pain index of the patient based on physiological signals collected by the signal acquisition assembly, and non-uniformly modulating the main pulse period parameters and multi-dimensional sub-pulse distribution parameters of the ultrasonic treatment transducer through an algorithm. The ultrasonic device can objectively evaluate the pain state of the patient by introducing multi-dimensional feedback feature information and evaluation mechanism, and can predict and adjust the patient's characteristics in advance. Through the dynamic change of pulse energy modulation, the specific nerve fibers can be accurately targeted, the analgesic effect is better, the side effects are significantly reduced, and the expected treatment effect is achieved.