40results about How to "Good analgesic effect" patented technology

The invention provides a compound phospholipid gel sustained release preparation and a preparation method thereof. The preparation mainly comprises a local anesthetic, a non-steroidal anti-inflammatory drug, phospholipid and water for injection. The preparation can be injected around a surgical incision or directly instilled or coated at the surgical incision to achieve the purpose of long-acting analgesia, and is used for postoperative analgesia.

The invention belongs to the technical field of medicines, discloses keratin CF5 as well as a preparation method, a pharmaceutical composition and application thereof, and particularly relates to keratin CF5, a nucleic acid molecule for coding the keratin CF5, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, and a preparation method of the keratin CF5. The invention relates to a keratin CF5-containing pharmaceutical composition and application of the keratin CF5, nucleic acid molecules, expression vectors, host cells or the pharmaceutical composition in preparation of antipyretic and analgesic, cough-relieving and phlegm-eliminating drugs, anticonvulsion, antiepilepsy, blood pressure lowering drugs, anti-inflammatory drugs and antiviral drugs, in particular to application of the keratin CF5, the nucleic acid molecules, the expression vectors, the host cells or the pharmaceutical composition in preparation of antipyretic and analgesic drugs.

The invention belongs to the technical field of medicine, and provides an external pharmaceutical composition for waist training injury pain and a patch thereof, the external pharmaceutical composition is prepared from scutellaria baicalensis, angelica sinensis, poria cocos, salvia miltiorrhiza, radix angelicae pubescentis, golden cypress, ligusticum wallichii, frankincense, garden balsam stem, safflower, galangal, liquorice and diclofenac sodium. According to the external medicine composition, the medicines generate a mutual synergistic effect in a manner of combined application of traditional Chinese medicines and western medicines, so that the purpose of enhancing the medicine effect is achieved, and the analgesic effect is remarkable. The combined action of Chinese and western medicines alleviates the side effect of pure western medicines and improves the problem of unstable curative effect of pure traditional Chinese medicines. The external medicine composition is high in safety, free of stimulation, exact in curative effect, free of pain in treatment, high in clinical cure rate and easy to accept by patients after being used for a long time.

The present invention belongs to the field of microbial technology, and specifically relates to the use of Akkermansia muciniphila in the preparation of products for preventing, treating and / or assisting in the treatment of pain. The present invention provides Akkermansia muciniphila, which has been deposited in the General Microbiological Center of the China Microbiological Culture Collection Administration on October 26, 2020, with a deposit number of CGMCC No. 20955. The Akkermansia muciniphila has a good analgesic effect, and its effect is equivalent to that of Fenbid Capsules.

The present invention discloses a probe sterile coupling agent patch that can improve the clarity of ultrasonic images and a preparation method thereof. The probe sterile coupling agent patch that can improve the clarity of ultrasonic images includes the following components by weight: 0.2-0.8 parts of carboxymethyl chitosan, 1-1.5 parts of sodium polyacrylate, 0.05 parts of silicon dioxide, 0.005 parts of gallium nitrate (GaNO3), and 10 parts of deionized water. The sterile coupling agent patch of the present application is simple in design and easy to use, and can be applied to various types of ultrasonic probes, with low cost and high utilization rate; it can eliminate the need to add coupling agent during operation, make the coupling agent layer more homogeneous, improve the imaging effect, reduce the ultrasonic preparation time, and reduce the loss of the ultrasonic probe; at the same time, it can shorten the operation time, reduce the operation trauma, improve the success rate of invasive operation, improve the anesthesia and analgesia effect, reduce the infection rate and anesthesia complications, extend the service life of ultrasound, benefit patients, and reduce the consumption of medical resources.

The invention discloses a eugenol soluble microneedle patch and a preparation method thereof. The eugenol soluble microneedle patch is composed of a microneedle array and a backing, the microneedle array is prepared from an amphiphilic polymer, a water-soluble polymer and eugenol, and the mass ratio of the amphiphilic polymer to the water-soluble polymer is 1: 1-3: 1; the ratio of the total mass of the amphiphilic polymer and the water-soluble polymer to the mass of the eugenol is (1: 1)-(6: 1). After the amorphous solid dispersion is prepared by a hot-melt extrusion method, the amorphous solid dispersion is pressed into the microneedle patch by a hot-pressing method, and the prepared microneedle patch is good in mechanical property and excellent in treatment effect on acute pain. Compared with combination of a traditional solution casting method, a hot melt extrusion technology and a hot pressing technology, the preparation technology of the microneedle is simplified, industrial production prospects are achieved, no organic reagent is used in the preparation process of the microneedle, and the production process is environmentally friendly.

The invention discloses a morphinan ring compound salt and a preparation method and application thereof. The invention discloses a salt of a cation as shown in a formula A. The preparation method of the salt of the cation as shown in the formula A comprises the following step: in a solvent, in the presence of an additive, reacting a compound 1 with acid to obtain the salt of the cation as shown in the formula A. The salt of the cation shown in the formula A has an excellent analgesic effect. # imgabs0 #

This invention provides a traditional Chinese medicine preparation for promoting blood circulation and relieving pain, and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from the following parts by weight of traditional Chinese medicine raw materials: 10-30 parts of Polygonatum sibiricum, 10-30 parts of Spatholobus suberectus, 10-30 parts of Curcuma longa, 5-20 parts of Sparganium stoloniferum, 5-20 parts of Areca catechu peel, 5-20 parts of Polygonum hydropiper, 5-20 parts of Rhizoma Scutellariae, 1-5 parts of Artemisia argyi, 5-20 parts of Solanum nigrum, 5-20 parts of Catechu, 10-30 parts of Scutellaria barbata, 5-20 parts of Aristolochia debilis, 10-30 parts of Astragalus membranaceus, and 5-20 parts of Artemisia argyi oil. The traditional Chinese medicine preparations described in this invention differ from those that typically enhance the efficacy of a single herb. Instead, they exhibit a synergistic relationship where one plus one equals more than two. The principal, assistant, adjuvant, and guide herbs complement each other, combining both tonifying and purging effects. This approach effectively promotes the dissipation of blood stasis, unblocks the flow of qi and blood in the meridians, eliminates local inflammation, and reduces swelling and pain. Simultaneously, it nourishes the tendons and bones, supports the body's vital energy, and enhances the body's ability to resist pathogens and repair damage. Thus, it comprehensively alleviates pain caused by various factors, achieving the goals of promoting blood circulation, removing blood stasis, clearing the meridians, reducing inflammation and swelling, and relieving pain.

The invention discloses a preparation method and application of lappaconitine analgesic hydrogel microneedles, which are used in the field of external application drugs, and the preparation method comprises the following steps: dissolving methylacryloylated sodium hyaluronate in a photocuring initiator 2, 4, 6-trimethylbenzoyl phenyl ethyl phosphonate to obtain a hyaluronic acid gel solution; the preparation method comprises the following steps: dissolving methacrylated chondroitin sulfate in a photocuring initiator 2, 4, 6-trimethylbenzoyl phenyl ethyl phosphonate to obtain a solution mixed with the methacrylated chondroitin sulfate; pre-filling an outer PDMS mold with the obtained hyaluronic acid gel solution to obtain an outer microneedle structure; the preparation method comprises the following steps: ultrasonically dissolving lappaconitine in a solution mixed with methacrylated chondroitin sulfate; and uniformly filling the lappaconitine solution into the obtained outer layer PDMS mold with the outer layer microneedle structure. Through the microneedle structure, lappaconitine can permeate into skin tissue more directly and more quickly.

The invention relates to a bupivacaine sustained-release gel injection as well as a preparation method and application thereof. The bupivacaine sustained-release gel injection comprises the following components: bupivacaine, a degradable polymer, an alkaline additive and a biocompatible organic solvent. The bupivacaine sustained-release gel injection provided by the invention has higher drug loading capacity and lower burst release level, is convenient to administrate, can release entrapped bupivacaine within 5-7 days, takes effect quickly, and can play a continuous analgesic role in vivo.

The present invention discloses an agonist of a TREK-1 potassium ion channel and its application in analgesic therapy. Specifically, the present invention discloses a compound that can activate the TREK-1 potassium ion channel, the compound has a significant analgesic effect, and can be used to prepare a pharmaceutical composition and preparation for preventing and / or treating chronic pain (muscle and soft tissue pain, bone and joint pain, headache, visceral pain, pathological neuralgia), acute pain, and cancer pain.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention provides a flow velocity adjustable analgesia pump, and relates to the technical field of medical equipment. Comprising a main body with a cavity; a medicine containing structure and a pressurizing structure are arranged in the main body; the medicine containing structure is connected with a first infusion tube; wherein the medicine containing structure at least comprises a soft bag body; the pressurizing structure is movably connected with the inner wall of the main body and can move between a first position and a second position; the pressurizing structure is not in contact with the medicine containing structure at the first position; and at the second position, the pressurizing structure can be in contact with the bag body and apply pressure to the bag body. According to the device, the medicine infusion flow rate can be flexibly adjusted, the analgesia requirements of patients after different operations are met, the wide clinical application prospect is achieved, and the postoperative comfort and life quality of the patients can be improved.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for improving lung deficiency type primary dysmenorrhea and a preparation method and application thereof. The traditional Chinese medicine composition specifically comprises multiple traditional Chinese medicine components including rhizoma polygonati, Chinese yam, rhizoma smilacis glabrae, radix salviae miltiorrhizae, yam rhizome, codonopsis pilosula, radix ophiopogonis from Sichuan of China, exocarpium citri grandis, spina date seeds, radix bupleuri, radix clematidis, morinda officinalis, rhodiola rosea, peach kernels, caulis spatholobi, southern apricot kernels and prepared rehmannia roots. The composition effectively relieves pain and improves accompanying symptoms through multi-target synergistic effects of promoting blood circulation to remove blood stasis, reinforcing qi and nourishing lung, warming kidney and strengthening spleen, regulating qi and relieving pain and the like. The formula follows the monarch, minister, assistant and guide theory of traditional Chinese medicine, is rigorous in compatibility, can comprehensively regulate qi, blood and viscera functions of a patient, is especially suitable for dysmenorrhea caused by deficiency of lung qi and unsmooth qi and blood circulation, and shows the advantages of overall treatment of traditional Chinese medicine. The preparation method is stable in process and easy to implement, and a safe and effective new choice for traditional Chinese medicine treatment is provided for lung deficiency type primary dysmenorrhea.

The present application relates to the technical field of medicine, in particular to the application of gushangamine alcohol in treating pain. The present application first discovers that gushangamine alcohol has significant analgesic activity through pharmacodynamics experiment. In the hot plate method and acetic acid writhing method mouse pain model, gushangamine alcohol shows good analgesic effect, and the analgesic effect is better than that of gushangmethyl, gushangheptane and gushangnonose, etc. C 20 type diterpene alkaloid in the same class of gushangbai, and has good dose dependence, and can be used for treating various painful diseases such as acute pain, chronic pain, inflammatory pain, neuropathic pain, cancer pain, postoperative pain and traumatic pain, and has good drug development and clinical application prospect.

The invention discloses a method for combining polygala tenuifolia with semen strychni and application thereof. A certain amount of polygala tenuifolia and semen strychni are decocted together or combined for use, so that the toxicity of the semen strychni can be remarkably reduced, and the LD50 value of several methods is obtained for the first time. Acetic acid twisting, mouse hot plate method experiments and mouse xylene induced ear swelling experiments are adopted to investigate the analgesic and anti-inflammatory effects before and after compatibility of the nux vomica with the polygala tenuifolia, and it is found for the first time that the anti-inflammatory and analgesic effects of the nux vomica can be increased in a polygala tenuifolia dose-dependent manner when the polygala tenuifolia is adopted for compatibility of the nux vomica. By adopting the method for matching the core-removed polygala tenuifolia with the sand-blanched semen strychni, the toxicity of the semen strychni can be remarkably reduced, and the anti-inflammatory and analgesic effects of the semen strychni can The method provides a new thought for the use, compatibility and processing of the nux vomica, and contributes to the improvement of the medication safety of the nux vomica.

The invention relates to the technical field of medical biological materials, and discloses a hydrogel microneedle dressing as well as a preparation method and application thereof. The hydrogel microneedle dressing comprises a substrate and a hydrogel needle tip positioned on the substrate, the hydrogel needle tip is prepared from the following raw materials in parts by weight: 20 to 40 parts of oxidized hyaluronic acid, 20 to 40 parts of carboxymethyl chitosan, 2 to 16 parts of iron-loaded ZIF-8 nanoparticles, 1 to 2 parts of glucose oxidase and 402 to 457 parts of water. The preparation method comprises the following steps: carrying out Schiff base reaction on carboxymethyl chitosan and oxidized hyaluronic acid to prepare hydrogel; loading the iron-loaded ZIF-8 nanoparticles and glucose oxidase on the hydrogel to obtain a needle tip precursor solution; and preparing the hydrogel microneedle dressing from the needle tip precursor solution and the substrate precursor solution through a hydrogel microneedle dressing forming process. The hydrogel microneedle dressing is used for preparing medical skin wound dressing, and the antibacterial effect under response of the internal environment is achieved.

The invention relates to the field of biotechnology, and specifically to a Tibetan medicine composition for treating calf yak diarrhea, and a preparation method and application thereof. The Tibetan medicine composition comprises the following raw materials in parts by weight: 5-10 parts of Aconite, 4-8 parts of Aconitum, and 4-8 parts of Rubia cordifolia; the pharmacological and pharmacodynamic screening of the effect of treating calf yak diarrhea is reasonable, the raw materials are easily available, the preparation process is simple, the operation is simple, and the composition is safe and effective; the Tibetan medicine composition of the invention can significantly inhibit the growth of bacteria and viruses, can significantly reduce the water content in mouse feces, and has good antidiarrheal effect, certain intestinal astringent effect, good anti-inflammatory effect and analgesic effect. The Tibetan medicine composition has been verified by clinical application experiments to have a significant effect on treating calf yak diarrhea, and has broad promotion and application value in the clinical application of plateau calf yak.

The present invention discloses a personalized planning and management system and method for gynecological postoperative rehabilitation paths, the method comprising the following steps: S1, collecting patient data; S2, analyzing and predicting the management plan of analgesics for patients in different rehabilitation paths based on the collected patient data, and selecting a preliminary rehabilitation path; S3, evaluating and continuously recording at different time points after surgery; S4, and simulating and predicting the analgesic effects and possible adverse reactions in different rehabilitation paths at different time points, and revising the preliminary rehabilitation path. By presetting a personalized analgesic plan and continuously evaluating the patient's pain state and analgesic effect, it is ensured that the patient can obtain the best analgesic effect at different rehabilitation points in the short term after surgery, and while ensuring effective analgesia, the use of opioids is selectively reduced, which effectively reduces the incidence of side effects of opioids, reduces the patient's dependence on opioids and the risk of addiction, and improves the safety of the rehabilitation process.

The invention discloses an intelligent electronic infusion pump and a control method thereof, and relates to the field of medical apparatuses and instruments and the field of intelligent infusion control, and the intelligent electronic infusion pump comprises a pump head, a liquid storage box, an infusion pipeline and an electronic control system; the control system monitors the number T of invalid self-control administration of the patient within the locking time, and according to the high demand state of the patient for the analgesic medicine reflected by the number of times, the effective self-control administration amount of this time is automatically increased for self-control administration signals appearing again within a certain time period after the locking time is ended. The larger the invalid self-control dosing times T in the locking time is, the larger the self-control dosing amount appearing again in the set time after the locking time is ended is. Individualized self-control administration infusion can be carried out, the occurrence rate of insufficient analgesia is reduced, and the analgesic effect is improved.

The invention belongs to the technical field of biomedical materials, and discloses a borneol analgesic type scald repair hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: under shielding gas, grafting gallic acid on polyvinyl alcohol to obtain gallic acid modified polyvinyl alcohol; the preparation method comprises the following steps: grafting 3-aminophenylboronic acid onto sodium alginate to obtain 3-aminophenylboronic acid modified sodium alginate; the preparation method comprises the following steps: coating chitosan on the surface of borneol by adopting a micro-emulsion method to obtain a modified nano borneol solution; dissolving gallic acid modified polyvinyl alcohol into the modified nano borneol solution, and uniformly mixing with the 3-aminophenylboronic acid modified sodium alginate solution and the Zn < 2 + > solution for crosslinking to obtain the borneol analgesic scald repair hydrogel material. The preparation method provided by the invention is simple to operate, and the prepared borneol analgesic scald repair hydrogel material integrates multiple functions of analgesia, self-healing, antibiosis and blood vessel formation promotion, and can effectively reduce pain at a wound and promote wound healing.

The invention relates to the technical field of anti-rheumatism medicines, in particular to an anti-rheumatism traditional Chinese medicine preparation as well as a preparation method and application of the anti-rheumatism traditional Chinese medicine preparation. 8-12 parts of Chinese angelica; 8-12 parts of ligusticum wallichii; 5-8 parts of safflower; 10 to 15 parts of fructus liquidambaris; 12 to 18 parts of coix seeds; 10 to 15 parts of radix astragali seu hedysari; through reasonable compatibility of the medicinal materials such as the garden balsam stem, the angelica sinensis and the ligusticum wallichii, a multi-element anti-inflammatory network is formed. Active components in the medicinal materials, such as gallic acid, ferulic acid, hydroxysafflor yellow A and the like, have a synergistic effect, so that the anti-inflammatory and analgesic effects of the preparation are remarkably enhanced. Experimental results show that the effect of the preparation in the aspect of inhibiting inflammatory factors such as TNF-alpha and IL-6 is improved by 50% or above compared with that of a single medicine extract.

The invention belongs to the technical field of medicine, and particularly relates to a degradable sustained-release local anesthetic microsphere and a preparation method and application thereof.The degradable sustained-release local anesthetic microsphere comprises a drug core and a carrier shell wrapping the outer layer of the drug core, the drug core is a local anesthetic, and the carrier shell wraps the outer layer of the drug core. The carrier shell is a composite material of a modified polylactic acid-glycolic acid copolymer (PLGA) and a biocompatible auxiliary material. According to the invention, the modified PLGA is used as a carrier material, the hydrophilicity and the drug compatibility of the carrier are improved through PEG modification, the encapsulation efficiency (greater than or equal to 85%) and the drug loading capacity (10%-30%) of the local anesthetic are obviously improved, the drug waste is reduced, and the drug utilization rate is improved.

The invention belongs to the technical field of medicines, and discloses keratin CF7 as well as a preparation method, a pharmaceutical composition and application thereof. In particular to keratin CF7, a nucleic acid molecule for coding the keratin CF7, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, a preparation method of the keratin CF7, a pharmaceutical composition containing the keratin CF7 and a preparation method of the keratin CF7. The invention also discloses application of the keratin CF7, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic and analgesic drugs, antitussive and expectorant drugs, anticonvulsion drugs, antiepileptic drugs, antihypertensive drugs, anti-inflammatory drugs and antiviral drugs.

The present application provides a kind of purple spot sea anemone polypeptide toxin HC-G02 and its synthesis method, application, its amino acid sequence is APCSGCYYQVGNECVYDKLKC-NH2. Linear peptide HC-G02 is synthesized by adopting polypeptide solid-phase synthesis method, and the purity of linear peptide after purification reaches more than 95%. Purple spot sea anemone oxidized peptide HC-G02 (the connection mode of disulfide bond is C1-C3, C2-C4) is obtained by site-directed oxidation. The present application is found through hot plate experiment test that purple spot sea anemone oxidized peptide HC-G02 has good analgesic effect on physical pain of mouse, and the pain threshold of mouse intraperitoneal injection oxidized peptide HC-G02 is gradually increased in 30min, and the pain threshold reaches the highest in 120min after administration. The analgesic effect of oxidized peptide HC-G02 at 50mg / kg is equivalent to the analgesic effect of tramadol at the same concentration, and the analgesic time is prolonged.

The invention relates to an azaspiro compound as well as a preparation method, a pharmaceutical composition and application thereof. The azaspiro compound has the structural characteristics as shown in the following formula (I). The azaspiro compound has an analgesic mechanism different from that of a traditional compound, and is good in analgesic effect and higher in safety. # imgabs0 #

The present invention relates to the field of medicine, and provides an ester bond compound and a preparation method and application thereof, and an analgesic drug. The structural formula of the ester bond compound provided by the present invention is shown in Formula I. Compared with the best analgesic combination "sinomenine + pregabalin" found in this laboratory, the ester bond compound provided by the present invention has a longer effective time and a stronger analgesic effect. At half the molar amount, it has a stronger analgesic effect, faster onset, longer analgesic time, and less fluctuation in efficacy than pregabalin, a first-line drug for treating pain; and the ester bond compound provided by the present invention can produce a stronger analgesic effect in vivo, and can reduce the occurrence of drug side effects by less dosage. In summary, the ester bond compound provided by the present invention can effectively control the development of the disease, improve the quality of life of patients, and has broad application prospects in pain treatment.

The application provides an ultrasonic device and a control method for real-time modulation of ultrasonic parameters based on pain monitoring, comprising a controller, a treatment head and a signal acquisition assembly, the treatment head comprising a shell and an ultrasonic treatment transducer, the side of the shell facing the patient being provided with an acoustic window for emitting treatment ultrasonic waves to the skin surface, the controller calculating a pain index of the patient based on physiological signals collected by the signal acquisition assembly, and non-uniformly modulating the main pulse period parameters and multi-dimensional sub-pulse distribution parameters of the ultrasonic treatment transducer through an algorithm. The ultrasonic device can objectively evaluate the pain state of the patient by introducing multi-dimensional feedback feature information and evaluation mechanism, and can predict and adjust the patient's characteristics in advance. Through the dynamic change of pulse energy modulation, the specific nerve fibers can be accurately targeted, the analgesic effect is better, the side effects are significantly reduced, and the expected treatment effect is achieved.

The invention belongs to the technical field of medical instruments, and discloses a rapid sedation and analgesia treatment needle which comprises a needle head and a needle handle, the needle head is an elastic hollow tube, a sealing film is arranged in the needle head, a first medicine cavity is formed in the needle handle, a piston cylinder is slidably connected in the first medicine cavity, a second medicine cavity is formed in the piston cylinder, and an opening is formed in the front end of the piston cylinder. According to the analgesic device, traditional Chinese medicine wrist-ankle needle analgesia and medicine analgesia are combined, the sedative and analgesic effect is improved, analgesia can be continuously conducted, after medicine injection of the first medicine cavity is conducted, the first medicine cavity is filled with medicine, the first medicine cavity is filled with medicine, and the second medicine cavity is filled with medicine. Anesthetic in the second medicine cavity can continuously flow out under the action of pressure and is similar to slow-release injection, and subsequent continuous analgesia can be guaranteed while rapid analgesia is achieved; the traditional Chinese medicine composition improves the analgesic effect, can rapidly and continuously relieve pain, solves the problem of insufficient sedative and analgesic effects in the prior art, and is suitable for sedative and analgesic of the wounded.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating osteoarthritis and a preparation method thereof. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 70-80 parts of salvia miltiorrhiza, 5-15 parts of pepper, 5-10 parts of ligusticum wallichii, 5-10 parts of rheum officinale, 5-10 parts of black prepared common monkshood daughter root, 5-10 parts of radix angelicae, 6-12 parts of angelica sinensis, 10-20 parts of astragalus membranaceus and 4-9 parts of divaricate saposhnikovia root. The traditional Chinese medicine composition has the effects of nourishing blood and activating blood, removing stasis and relieving pain, and expelling wind and removing cold, and has the effects of treating blood before treating wind and automatically extinguishing wind; the effects of opening the striae and treating the interior by external use are achieved. Besides, pharmacological experiments of the traditional Chinese medicine composition show that the traditional Chinese medicine composition has a good analgesic effect and can weaken inflammatory response, meanwhile, the traditional Chinese medicine composition is definite in curative effect, safe, convenient, small in side effect and low in price, clinical medication varieties are increased, and clinical requirements are met.