19results about How to "Good analgesic effect" patented technology

The invention provides a compound phospholipid gel sustained release preparation and a preparation method thereof. The preparation mainly comprises a local anesthetic, a non-steroidal anti-inflammatory drug, phospholipid and water for injection. The preparation can be injected around a surgical incision or directly instilled or coated at the surgical incision to achieve the purpose of long-acting analgesia, and is used for postoperative analgesia.

The invention belongs to the technical field of medicine, and provides an external pharmaceutical composition for waist training injury pain and a patch thereof, the external pharmaceutical composition is prepared from scutellaria baicalensis, angelica sinensis, poria cocos, salvia miltiorrhiza, radix angelicae pubescentis, golden cypress, ligusticum wallichii, frankincense, garden balsam stem, safflower, galangal, liquorice and diclofenac sodium. According to the external medicine composition, the medicines generate a mutual synergistic effect in a manner of combined application of traditional Chinese medicines and western medicines, so that the purpose of enhancing the medicine effect is achieved, and the analgesic effect is remarkable. The combined action of Chinese and western medicines alleviates the side effect of pure western medicines and improves the problem of unstable curative effect of pure traditional Chinese medicines. The external medicine composition is high in safety, free of stimulation, exact in curative effect, free of pain in treatment, high in clinical cure rate and easy to accept by patients after being used for a long time.

The present invention discloses a probe sterile coupling agent patch that can improve the clarity of ultrasonic images and a preparation method thereof. The probe sterile coupling agent patch that can improve the clarity of ultrasonic images includes the following components by weight: 0.2-0.8 parts of carboxymethyl chitosan, 1-1.5 parts of sodium polyacrylate, 0.05 parts of silicon dioxide, 0.005 parts of gallium nitrate (GaNO3), and 10 parts of deionized water. The sterile coupling agent patch of the present application is simple in design and easy to use, and can be applied to various types of ultrasonic probes, with low cost and high utilization rate; it can eliminate the need to add coupling agent during operation, make the coupling agent layer more homogeneous, improve the imaging effect, reduce the ultrasonic preparation time, and reduce the loss of the ultrasonic probe; at the same time, it can shorten the operation time, reduce the operation trauma, improve the success rate of invasive operation, improve the anesthesia and analgesia effect, reduce the infection rate and anesthesia complications, extend the service life of ultrasound, benefit patients, and reduce the consumption of medical resources.

This invention provides a traditional Chinese medicine preparation for promoting blood circulation and relieving pain, and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from the following parts by weight of traditional Chinese medicine raw materials: 10-30 parts of Polygonatum sibiricum, 10-30 parts of Spatholobus suberectus, 10-30 parts of Curcuma longa, 5-20 parts of Sparganium stoloniferum, 5-20 parts of Areca catechu peel, 5-20 parts of Polygonum hydropiper, 5-20 parts of Rhizoma Scutellariae, 1-5 parts of Artemisia argyi, 5-20 parts of Solanum nigrum, 5-20 parts of Catechu, 10-30 parts of Scutellaria barbata, 5-20 parts of Aristolochia debilis, 10-30 parts of Astragalus membranaceus, and 5-20 parts of Artemisia argyi oil. The traditional Chinese medicine preparations described in this invention differ from those that typically enhance the efficacy of a single herb. Instead, they exhibit a synergistic relationship where one plus one equals more than two. The principal, assistant, adjuvant, and guide herbs complement each other, combining both tonifying and purging effects. This approach effectively promotes the dissipation of blood stasis, unblocks the flow of qi and blood in the meridians, eliminates local inflammation, and reduces swelling and pain. Simultaneously, it nourishes the tendons and bones, supports the body's vital energy, and enhances the body's ability to resist pathogens and repair damage. Thus, it comprehensively alleviates pain caused by various factors, achieving the goals of promoting blood circulation, removing blood stasis, clearing the meridians, reducing inflammation and swelling, and relieving pain.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for improving lung deficiency type primary dysmenorrhea and a preparation method and application thereof. The traditional Chinese medicine composition specifically comprises multiple traditional Chinese medicine components including rhizoma polygonati, Chinese yam, rhizoma smilacis glabrae, radix salviae miltiorrhizae, yam rhizome, codonopsis pilosula, radix ophiopogonis from Sichuan of China, exocarpium citri grandis, spina date seeds, radix bupleuri, radix clematidis, morinda officinalis, rhodiola rosea, peach kernels, caulis spatholobi, southern apricot kernels and prepared rehmannia roots. The composition effectively relieves pain and improves accompanying symptoms through multi-target synergistic effects of promoting blood circulation to remove blood stasis, reinforcing qi and nourishing lung, warming kidney and strengthening spleen, regulating qi and relieving pain and the like. The formula follows the monarch, minister, assistant and guide theory of traditional Chinese medicine, is rigorous in compatibility, can comprehensively regulate qi, blood and viscera functions of a patient, is especially suitable for dysmenorrhea caused by deficiency of lung qi and unsmooth qi and blood circulation, and shows the advantages of overall treatment of traditional Chinese medicine. The preparation method is stable in process and easy to implement, and a safe and effective new choice for traditional Chinese medicine treatment is provided for lung deficiency type primary dysmenorrhea.

The present application relates to the technical field of medicine, in particular to the application of gushangamine alcohol in treating pain. The present application first discovers that gushangamine alcohol has significant analgesic activity through pharmacodynamics experiment. In the hot plate method and acetic acid writhing method mouse pain model, gushangamine alcohol shows good analgesic effect, and the analgesic effect is better than that of gushangmethyl, gushangheptane and gushangnonose, etc. C 20 type diterpene alkaloid in the same class of gushangbai, and has good dose dependence, and can be used for treating various painful diseases such as acute pain, chronic pain, inflammatory pain, neuropathic pain, cancer pain, postoperative pain and traumatic pain, and has good drug development and clinical application prospect.

The invention discloses a method for combining polygala tenuifolia with semen strychni and application thereof. A certain amount of polygala tenuifolia and semen strychni are decocted together or combined for use, so that the toxicity of the semen strychni can be remarkably reduced, and the LD50 value of several methods is obtained for the first time. Acetic acid twisting, mouse hot plate method experiments and mouse xylene induced ear swelling experiments are adopted to investigate the analgesic and anti-inflammatory effects before and after compatibility of the nux vomica with the polygala tenuifolia, and it is found for the first time that the anti-inflammatory and analgesic effects of the nux vomica can be increased in a polygala tenuifolia dose-dependent manner when the polygala tenuifolia is adopted for compatibility of the nux vomica. By adopting the method for matching the core-removed polygala tenuifolia with the sand-blanched semen strychni, the toxicity of the semen strychni can be remarkably reduced, and the anti-inflammatory and analgesic effects of the semen strychni can The method provides a new thought for the use, compatibility and processing of the nux vomica, and contributes to the improvement of the medication safety of the nux vomica.

The invention relates to the field of biotechnology, and specifically to a Tibetan medicine composition for treating calf yak diarrhea, and a preparation method and application thereof. The Tibetan medicine composition comprises the following raw materials in parts by weight: 5-10 parts of Aconite, 4-8 parts of Aconitum, and 4-8 parts of Rubia cordifolia; the pharmacological and pharmacodynamic screening of the effect of treating calf yak diarrhea is reasonable, the raw materials are easily available, the preparation process is simple, the operation is simple, and the composition is safe and effective; the Tibetan medicine composition of the invention can significantly inhibit the growth of bacteria and viruses, can significantly reduce the water content in mouse feces, and has good antidiarrheal effect, certain intestinal astringent effect, good anti-inflammatory effect and analgesic effect. The Tibetan medicine composition has been verified by clinical application experiments to have a significant effect on treating calf yak diarrhea, and has broad promotion and application value in the clinical application of plateau calf yak.

The invention discloses an intelligent electronic infusion pump and a control method thereof, and relates to the field of medical apparatuses and instruments and the field of intelligent infusion control, and the intelligent electronic infusion pump comprises a pump head, a liquid storage box, an infusion pipeline and an electronic control system; the control system monitors the number T of invalid self-control administration of the patient within the locking time, and according to the high demand state of the patient for the analgesic medicine reflected by the number of times, the effective self-control administration amount of this time is automatically increased for self-control administration signals appearing again within a certain time period after the locking time is ended. The larger the invalid self-control dosing times T in the locking time is, the larger the self-control dosing amount appearing again in the set time after the locking time is ended is. Individualized self-control administration infusion can be carried out, the occurrence rate of insufficient analgesia is reduced, and the analgesic effect is improved.

The invention belongs to the technical field of biomedical materials, and discloses a borneol analgesic type scald repair hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: under shielding gas, grafting gallic acid on polyvinyl alcohol to obtain gallic acid modified polyvinyl alcohol; the preparation method comprises the following steps: grafting 3-aminophenylboronic acid onto sodium alginate to obtain 3-aminophenylboronic acid modified sodium alginate; the preparation method comprises the following steps: coating chitosan on the surface of borneol by adopting a micro-emulsion method to obtain a modified nano borneol solution; dissolving gallic acid modified polyvinyl alcohol into the modified nano borneol solution, and uniformly mixing with the 3-aminophenylboronic acid modified sodium alginate solution and the Zn < 2 + > solution for crosslinking to obtain the borneol analgesic scald repair hydrogel material. The preparation method provided by the invention is simple to operate, and the prepared borneol analgesic scald repair hydrogel material integrates multiple functions of analgesia, self-healing, antibiosis and blood vessel formation promotion, and can effectively reduce pain at a wound and promote wound healing.

The invention relates to the technical field of anti-rheumatism medicines, in particular to an anti-rheumatism traditional Chinese medicine preparation as well as a preparation method and application of the anti-rheumatism traditional Chinese medicine preparation. 8-12 parts of Chinese angelica; 8-12 parts of ligusticum wallichii; 5-8 parts of safflower; 10 to 15 parts of fructus liquidambaris; 12 to 18 parts of coix seeds; 10 to 15 parts of radix astragali seu hedysari; through reasonable compatibility of the medicinal materials such as the garden balsam stem, the angelica sinensis and the ligusticum wallichii, a multi-element anti-inflammatory network is formed. Active components in the medicinal materials, such as gallic acid, ferulic acid, hydroxysafflor yellow A and the like, have a synergistic effect, so that the anti-inflammatory and analgesic effects of the preparation are remarkably enhanced. Experimental results show that the effect of the preparation in the aspect of inhibiting inflammatory factors such as TNF-alpha and IL-6 is improved by 50% or above compared with that of a single medicine extract.

The invention belongs to the technical field of medicine, and particularly relates to a degradable sustained-release local anesthetic microsphere and a preparation method and application thereof.The degradable sustained-release local anesthetic microsphere comprises a drug core and a carrier shell wrapping the outer layer of the drug core, the drug core is a local anesthetic, and the carrier shell wraps the outer layer of the drug core. The carrier shell is a composite material of a modified polylactic acid-glycolic acid copolymer (PLGA) and a biocompatible auxiliary material. According to the invention, the modified PLGA is used as a carrier material, the hydrophilicity and the drug compatibility of the carrier are improved through PEG modification, the encapsulation efficiency (greater than or equal to 85%) and the drug loading capacity (10%-30%) of the local anesthetic are obviously improved, the drug waste is reduced, and the drug utilization rate is improved.

The present application provides a kind of purple spot sea anemone polypeptide toxin HC-G02 and its synthesis method, application, its amino acid sequence is APCSGCYYQVGNECVYDKLKC-NH2. Linear peptide HC-G02 is synthesized by adopting polypeptide solid-phase synthesis method, and the purity of linear peptide after purification reaches more than 95%. Purple spot sea anemone oxidized peptide HC-G02 (the connection mode of disulfide bond is C1-C3, C2-C4) is obtained by site-directed oxidation. The present application is found through hot plate experiment test that purple spot sea anemone oxidized peptide HC-G02 has good analgesic effect on physical pain of mouse, and the pain threshold of mouse intraperitoneal injection oxidized peptide HC-G02 is gradually increased in 30min, and the pain threshold reaches the highest in 120min after administration. The analgesic effect of oxidized peptide HC-G02 at 50mg / kg is equivalent to the analgesic effect of tramadol at the same concentration, and the analgesic time is prolonged.

The invention relates to an azaspiro compound as well as a preparation method, a pharmaceutical composition and application thereof. The azaspiro compound has the structural characteristics as shown in the following formula (I). The azaspiro compound has an analgesic mechanism different from that of a traditional compound, and is good in analgesic effect and higher in safety. # imgabs0 #

The application provides an ultrasonic device and a control method for real-time modulation of ultrasonic parameters based on pain monitoring, comprising a controller, a treatment head and a signal acquisition assembly, the treatment head comprising a shell and an ultrasonic treatment transducer, the side of the shell facing the patient being provided with an acoustic window for emitting treatment ultrasonic waves to the skin surface, the controller calculating a pain index of the patient based on physiological signals collected by the signal acquisition assembly, and non-uniformly modulating the main pulse period parameters and multi-dimensional sub-pulse distribution parameters of the ultrasonic treatment transducer through an algorithm. The ultrasonic device can objectively evaluate the pain state of the patient by introducing multi-dimensional feedback feature information and evaluation mechanism, and can predict and adjust the patient's characteristics in advance. Through the dynamic change of pulse energy modulation, the specific nerve fibers can be accurately targeted, the analgesic effect is better, the side effects are significantly reduced, and the expected treatment effect is achieved.

The present application provides a device for lumbar puncture anesthesia and analgesia with an intraspinal indwelling needle, the indwelling needle comprises a needle holding isolation part, the bottom end of the needle holding isolation part is connected to a catheter, a steel needle tube wall is penetrated by the inner side of the needle holding isolation part and the catheter, a steel needle column is penetrated by the inner side of the steel needle tube wall, a limiting rebound part is provided at the position where the upper and lower ends of the steel needle tube wall are connected to the steel needle column, the steel needle column is rotatably connected to the inner side of the steel needle tube wall through the limiting rebound part, and a two-way blocking part is provided at the connection position between the sharp end of the bottom of the steel needle tube wall and the catheter; the present invention uses the two-way blocking part to ensure that the catheter stably enters the patient's body when following the steel needle into the patient's body, thereby improving the success rate of puncture use of the indwelling needle, and at the same time, the outer wall of the catheter can be opened after the catheter puncture is completed or before the puncture, so that when the anesthetic analgesic agent is transported inside the catheter, the patient's puncture position can be injected with multiple depths at the same time, thereby accelerating the effects of anesthesia and analgesia.

The utility model discloses a puncture patch loaded with compound lidocaine emulsifiable paste, which relates to the technical field of compound lidocaine emulsifiable paste patches and comprises a compound lidocaine emulsifiable paste patch component, and fixing structures are fixedly mounted on the periphery of the outer wall of the compound lidocaine emulsifiable paste patch component. A double-sided attaching assembly is attached to the upper end of the compound lidocaine emulsifiable paste attaching assembly, a patient can attach compound lidocaine emulsifiable paste to the upper portion of an infusion base for one hour before infusion or maintenance according to the needs of the patient, the purpose of painlessness is achieved when the patient inserts a needle, the emulsifiable paste is wiped cleanly with a cotton swab after one hour, and the patient can conveniently use the compound lidocaine emulsifiable paste. A doctor punctures a patient after conventionally disinfecting the skin of the patient, and the compound lidocaine cream is used, so that the analgesic effect is obvious when the patient punctures, the administration dosage is accurate, the absorption area is fixed, the compound lidocaine cream can be added, reduced and replaced at any time, and the puncture pain of the patient is reduced.

The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of a burdock extract and application of the burdock extract in antipyretic and analgesic medicines. The preparation method comprises the following steps: crushing and sieving burdock, and carrying out ultrasonic extraction by using an ethanol water solution; concentrating under reduced pressure, recovering the solvent until no alcohol smell exists, and diluting with 95% ethanol and purified water; and enabling the concentrated solution to pass through a macroporous adsorption resin column, eluting with purified water to remove impurities, collecting an ethanol water eluent, and concentrating and drying under reduced pressure to obtain the burdock extract. A mouse fever model induced by dry yeast proves that the fructus arctii extract can remarkably reduce the anus temperature of a fever mouse and has a good antipyretic effect; a mouse writhing pain model proves that the fructus arctii extract has a good analgesic effect. The invention provides a new source for seeking safe and effective antipyretic and analgesic drugs.