69results about How to "Good hemostasis" patented technology

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The utility model relates to a novel biological electrocoagulation and electroresection snare device for a pedicle in a urinary cavity, which is used for effectively improving the operation safety and preventing normal tissues from being damaged by resection operation, and the operation is simple, more convenient and more flexible. Comprising an operating handle, an upper sliding block, a lower sliding block, a first metal wire and a second metal wire, the operating handle is provided with a longitudinal cavity penetrating through the front end of the operating handle, and the upper sliding block and the lower sliding block are installed on the operating handle through a longitudinal sliding structure. Main bodies of the first metal wire and the second metal wire are located in the longitudinal cavity, and the rear ends of the first metal wire and the second metal wire are fixedly connected with the lower sliding block and the upper sliding block respectively; the front end of the first metal wire is bent and then welded with a first metal wire body to form a restraint ring, and the first metal wire body penetrates through the restraint ring to form an electrocoagulation and electroresection snare outside the front end face of the operating handle; and the front end of the second metal wire is welded with the first metal wire body at a position adjacent to the restraint ring.

The present invention discloses an L-shaped fiber supramolecule and its preparation method and application. The structural formula of the L-shaped fiber supramolecule is shown in formula (I). The preparation method includes: activation of resin, coupling of amino acids, excision and precipitation of polypeptides, and separation and purification of polypeptides. The L-shaped fiber supramolecule prepared by the present invention has good biocompatibility, does not cause inflammatory reaction at the wound site, has the function of binding calcium ions, and exhibits excellent effects in hemostasis and bone regeneration. #imgabs0#

The invention discloses a tobacco extract for promoting wound healing, the tobacco extract comprises a tobacco acid water layer extract and a tobacco alcohol layer extract, the tobacco acid water layer extract and the tobacco alcohol layer extract are both mixtures of nicotine, chlorogenic acid and solanesol, and a preparation method of the tobacco extract comprises the steps of tobacco extraction, extraction treatment, purification pretreatment and purification treatment. The invention also discloses an application of the tobacco extract in promoting wound healing. The traditional Chinese medicine has the advantages of being convenient to use and small in side effect, wound healing can be promoted, meanwhile, the effects of local bacteriostasis, anti-inflammation, angiogenesis promotion and the like are achieved, complications such as wound infection are avoided, and the traditional Chinese medicine comprehensively plays a role in different stages of wound healing.

The invention relates to a rapid self-gelation modified gelatin-based styptic powder composition as well as a preparation method and application thereof. The styptic powder is composed of phenylboronic acid modified gelatin and a long-chain polymer containing a diol structure, and can be used independently or matched with thrombin or polyethylene glycol active derivative powder to prepare a composition for use. Under physiological conditions, the powder can rapidly absorb blood, settle and self-crosslink to form hydrogel, activate an endogenous hemostasis pathway and perform physical plugging, and rapid hemostasis is realized. When used together with thrombin, the medicine can maintain local high concentration and accelerate blood clot formation, and is suitable for emergency control of massive hemorrhage. When the hydrogel is combined with a polyethylene glycol active derivative, tissue adhesion and a dual-network structure can be realized, the gel strength is improved, and long-acting hemostasis is realized.

The utility model discloses a disposable radio frequency plasma scalpel head for narrow window surgery. The disposable radio frequency plasma scalpel head comprises a handle, a scalpel head body, a water injection pipe and a power line, wherein the scalpel head body, the water injection pipe and the power line are respectively connected with the handle; the tool bit body comprises a tool body installed on the handle, an electrode base installed at the front end of the tool body, an electrode body installed on the electrode base and an electrode insulating sleeve arranged on the electrode body in a sleeving mode. The power line is electrically connected with the electrode body and the knife body. When the front end of the electrode body extends outwards, the thickness is gradually reduced to form a cutting edge shape, and the tail end of the electrode body is completely attached to the end face of the matched position of the electrode base. The electrode body is used for stripping soft tissues and performing excision ablation treatment on minimal lesions in narrow positions, so that the problems of weak cutting energy, long operation time, poor hemostatic effect, limited working electrode angle and incapability of realizing fine cutting in the field of the conventional narrow window surgical knife head are solved.

The invention discloses an opening switching mechanism and a tracheal catheter, and relates to the technical field of medical instruments. The opening switching mechanism is used on a tube body of the tracheal catheter, a first opening is formed in the side wall of the tube body, a second opening is formed in the far end of the tube body, the opening switching mechanism comprises an inner tube, and the inner tube is arranged in the tube body in a sliding mode; a communicating port is formed in the side wall of the inner tube, a deformation assembly is arranged at the far end of the inner tube and at least has a first state enabling the second opening to be opened and a second state enabling the second opening to be closed, the communicating port and the first opening are completely staggered based on sliding of the inner tube, and the deformation assembly is in the first state. Or the communication port is at least partially overlapped with the first opening, and the deformation assembly is in the second state. According to the opening switching mechanism, switching between the state of the first opening and the state of the second opening can be completed only through one step, the switching efficiency of the state of the first opening and the state of the second opening is improved, and the operation steps of the tracheal catheter are simplified.

The invention provides a silk fibroin compound loaded with a polyhydroxy phenolic compound and a preparation method of the silk fibroin compound, aiming at the defect that the existing hemostatic material has a poor effect on large wounds and serious bleeding, and the silk fibroin compound loaded with the polyhydroxy phenolic compound is prepared by self-assembly of the polyhydroxy phenolic compound and silk fibroin; wherein the silk fibroin is subjected to a beta folding conformation transformation process, the polyhydroxy phenolic compound is preferably an indissolvable compound and most preferably ellagic acid, and the feeding ratio of the polyhydroxy phenolic compound to the silk fibroin is the mass ratio lt; 1: 1, preferably 1: 2-1: 16, and more preferably 1: 4. The hemostatic capacity of the compound is obviously better than that of polyhydroxy phenolic compounds, silk fibroin, Yunnan Baiyao, tranexamic acid, chitosan hemostatic powder and the like. Meanwhile, compared with silk fibroin, the silk fibroin is larger in particle size and heavier in texture, and can quickly settle to a bleeding opening in blood. The compound is free of cytotoxicity, free of hemolysis, capable of being self-degraded in vivo and high in safety. Meanwhile, the hydrogel has the characteristics of wound healing, antibiosis, anti-infection, anti-adhesion and the like, and can be applied to preparation of corresponding preparations.

The utility model discloses a blood vessel compression hemostasis device, belongs to the technical field of medical supplies, and is used for solving the technical problems that a common binding tourniquet is not easy to master the compression force on a blood vessel after binding and the binding hemostasis efficiency is low. The utility model discloses a blood vessel compression hemostasis device which comprises a hemostasis patch and a compression belt. The compression belt comprises an elastic section, a scale and a fastener; the scale comprises a second fixed end and a marking part; the first fixed end and the second fixed end of the elastic section are fixedly connected; the ruler is arranged in the elastic stretching direction of the elastic section, the distance between the second fixing end and the marking part is larger than the length of the elastic section, and the marking part is used for marking the stretching position of the elastic section. The fastener is located at the end of the compression belt and can fix the stretching length of the elastic section, so that the compression belt conducts compression hemostasis on the blood vessel through the hemostasis patch. The blood vessel compression hemostasis device is convenient to operate, and the hemostasis effect is improved.

This invention belongs to the field of biomedical materials technology, specifically relating to an oxidized hyaluronic acid / carboxymethyl chitosan hemostatic sponge and its preparation method. The preparation method includes: oxidizing hyaluronic acid with sodium periodate to obtain oxidized hyaluronic acid; preparing aqueous solutions of oxidized hyaluronic acid and carboxymethyl chitosan; mixing the two solutions and forming a hydrogel through a Schiff base reaction between aldehyde and amino groups; cryogelatinizing the hydrogel at low temperature and then freeze-drying it under vacuum to obtain an expandable hemostatic sponge with a three-dimensional interconnected porous structure. Upon contact with blood, the sponge of this invention rapidly absorbs water and expands, increasing in volume by more than three times, forming a tight physical seal. Simultaneously, it adsorbs and activates platelets to accelerate coagulation, achieving highly efficient hemostasis. This sponge exhibits excellent biocompatibility, is completely degradable in vivo, and the preparation process is mild and requires no toxic cross-linking agents. It can be used for rapid hemostasis of deep, irregular, and non-compressible bleeding wounds.

According to the multifunctional conductive nanofiber composite material and the preparation method and application thereof, a conductive nanofiber membrane is prepared through an ultrasonic driving method, and the multifunctional conductive nanofiber composite material has the advantages of being low in filler content, adjustable in material conductivity, low in energy consumption, small in equipment occupied area and easy to operate; by adopting pre-stretching treatment, formation of an RGO scale structure on the surface of the fiber is facilitated, and modification of PDMS can improve the stability of an interface (RGO and the surface of the fiber) and can further guarantee the stability of the scale structure; due to the introduction of PDMS, the hydrophobic property of the material is improved, and the use of fluorine-containing low-surface-energy substances is avoided; according to the invention, hydrophobicity and photo-thermal properties of the material are combined, the application range of the material is greatly widened, and the material is used for stress sensing materials, photo-thermal materials or medical gauzes.

The invention relates to a hemostatic material capable of efficiently inhibiting bleeding and promoting wound repair as well as a preparation method and application of the hemostatic material. The hemostatic material is prepared from mutant human thrombin and oxidizing bacterial cellulose nano short fibers. The hemostatic material disclosed by the invention can realize dual effects of inhibiting bleeding in vivo and promoting wound repair, greatly improves the wound repair effect on the premise of rapidly inhibiting bleeding, and has a good market application prospect.

The utility model relates to medical consumable technical field, and specifically discloses a sterile finger cots lamp on operating table, including lamp pearl shell body, one end of lamp pearl shell body is equipped with the lamp pearl, the other end of lamp pearl shell body is equipped with connecting piece, and connecting piece includes the connecting shell body fixed connection with lamp pearl shell body, and the front end of connecting shell body can be telescopic and is arranged, and the side of connecting shell body is equipped with magic band for being bound with the finger. The utility model can realize the flexible and various timely lighting operation of wearing on the finger, effectively shortens the operation time, and improves the work efficiency.

The utility model discloses a "O" vaseline gauze special for penis operation, including the long strip vaseline gauze, the middle part of vaseline gauze forms the long strip opening along vaseline gauze width direction extension, vaseline gauze top edge fixedly has the pad and presses the convex, and the pad and press the convex at the opening one side. After one end of vaseline gauze passes through the opening, the middle part forms the "O" type structure, and the pad and press the convex are at the "O" type structure. The utility model discloses good adhesion, and it is convenient to adjust the compression strength to the wound, and the hemostatic effect is remarkable, effectively reduces the discomfort of the patient when bandaging, and it is convenient to quick bandaging and replacement.

The invention provides a pure inorganic waxy active material and a preparation method and application thereof, and belongs to the technical field of medical materials.The preparation method of the pure inorganic waxy active material comprises the following steps that a sodium polyphosphate solution and a divalent cation solution are mixed and chelated, and waxy co-doped polyphosphate CoPPW is obtained; the divalent cation solution is a solution containing any one, two or three of Ca < 2 + >, Mg < 2 + > and Sr < 2 + >. The pure inorganic waxy active material provided by the invention has certain strength, can be molded and degraded, and has the effects of resisting bacteria, stopping bleeding, repairing bone defects and the like.

The invention provides a preparation method of a biological tissue adhesive, which comprises the following steps: (1) respectively dissolving polyacrylic acid and polyethyleneimine in deionized water to prepare a polyacrylic acid aqueous solution and a polyethyleneimine aqueous solution; (2) blending the polyacrylic acid aqueous solution, the polyethyleneimine aqueous solution and the inorganic hemostatic material, and fully stirring to obtain a copolymer of the three substances; (3) immersing the copolymer into liquid nitrogen for pre-freezing, and then freeze-drying; and (4) taking out the freeze-dried sample, and grinding the sample into powder to obtain the biological tissue adhesive powder. The hemostatic adhesive powder is simple and convenient to apply, has a remarkable hemostatic effect and can be used for effectively stopping bleeding under various bleeding conditions.

The present application relates to the technical field of wound dressing material, and in particular to a preparation method and application of a glycosylated (galactose-tyrosine-Fmoc) chitosan derivative.The glycosylated (galactose-tyrosine-Fmoc) chitosan derivative is synthesized through Fischer reaction, nucleophilic substitution reaction, addition-elimination reaction and the like.The compound can form a hydrogel, and the hydrogel not only has good selective sterilization effect on pseudomonas aeruginosa, but also has broad-spectrum sterilization activity and hemostatic function, and has a broad application prospect in the field of wound dressings.

The utility model belongs to the field of hemodialysis, particularly relates to a hemodialysis hemostat, and aims to solve the problems that a wound of a patient is easily touched due to the fact that a base is not positioned and fixed and can be driven to shake and move in the process of rotating a rotating handle in the prior art, the wound is worsened, unnecessary pain is superposed, and the using effect is reduced. According to the technical scheme, the device comprises a base, two sliding grooves are formed in the top of the base, two sliding blocks are slidably connected to the interior of each sliding groove, the four sliding blocks are divided into two groups, and a movable frame is fixedly installed between the tops of the sliding blocks in each group; and the fixed storage mechanism is arranged on the base and used for positioning and fixing the base. When the hemostasis device is used, the base can be adsorbed to a table top, the positioning and fixing effects are achieved, the situation that when hemostasis is conducted on a wound of a patient, the base is driven to shake and move, the wound of the patient is touched, the wound is worsened, and unnecessary pain is caused is avoided.

The utility model relates to an interventional postoperative puncture port air bag compression bag which comprises wrapping cloth and an air bag, a waist bandage is arranged on the outer upper edge of the wrapping cloth, the waist bandage is wound around the waist of a patient and is fixed through hook-and-loop fasteners in a sticking mode, and a leg bandage is arranged on the outer lower edge of the wrapping cloth, is wound around the thighs of the patient and is fixed through hook-and-loop fasteners in a sticking mode. The bag is arranged on the inner surface of the wrapping cloth and is pressed at the interventional operation puncture port of the patient, the bag is provided with an inflation port, the inflation port is connected with an inflation balloon, and the inflation balloon is provided with a deflation valve. The wrapping cloth inner face bag is fixed to the crotch of a patient through the waist binding band and the leg binding band, compression hemostasis is conducted on an interventional operation puncture opening, firmness is good, wearing is comfortable, and the hemostasis effect is good. The length of the waist bandage and the length of the leg bandage can be adjusted according to needs, and the device is suitable for patients of different body types. The inflatable balloon is extruded to inject air into the bag, the vent valve is opened to discharge air out of the bag, the compression degree of the bag can be adjusted, and operation is easy and convenient.

The present application provides a gelatin particle and a preparation method thereof, and a hemostatic fluid gelatin composition. The gelatin particle is a cross-linked gelatin particle, and the preparation raw material of the gelatin particle comprises gelatin and a high molecular material containing amino and / or carboxyl; the preparation process of the gelatin particle comprises the steps of forming a gelatin gel from the gelatin and crushing the gelatin gel, wherein the high molecular material is added to mix with the solution of the gelatin or the gelatin gel before or after the formation of the gelatin gel. The gelatin particle and the hemostatic fluid gelatin of the present application can quickly absorb the moisture in the blood after being applied to a bleeding wound, thereby increasing the concentration of red blood cells, blood coagulation factors and the like in the blood, accelerating the endogenous blood coagulation mechanism, and having a good hemostatic effect.

The present invention relates to a composite hydrogel based on biological ionic liquid polymerization and a preparation method thereof, and belongs to the field of material technology. A composite hydrogel based on biological ionic liquid polymerization, the composite hydrogel has a three-dimensional network structure, and the three-dimensional network structure is interwoven by two networks: one: a network formed by polymerization of biological ionic liquid and methacryloyl hyaluronic acid, and self-crosslinking of methacryloyl hyaluronic acid; the other: a network formed by oxidized hyaluronic acid and ε-polylysine through an imine bond. The hydrogel prepared by the present invention can be applied to the bleeding part, and can play a role in rapid hemostasis, long-term antibacterial and thus promoting wound healing.

The invention provides a joint-control switching assembly and a tracheal catheter, and relates to the technical field of medical instruments.The joint-control switching assembly comprises a catheter body, a joint-control switching assembly and a tracheal catheter, the catheter body is provided with a near-end opening, a far-end opening and a side opening, and the side opening is formed in the catheter wall, close to the far-end opening, of the catheter body; the balloons are arranged on the tube body in an inflatable mode, the balloons can block the main air tube or the branch air tube in the inflatable state, and at least one balloon is arranged on each of the two sides of the side opening in the axis direction of the tube body; the air bag is arranged in the tube body in an inflatable mode and is close to the far-end opening, and the air bag can block the tube body in the inflatable state; the ventilation piece is installed on the catheter body and used for transmitting gas, the ventilation piece has a first state and a second state which can be switched, the ventilation piece in the first state can be communicated with the multiple balloons, and the ventilation piece in the second state can be communicated with the air bag and the multiple balloons. Compared with the prior art, the tracheal catheter has the advantage that the operation steps of the tracheal catheter are simplified.

The present invention discloses a chiral hemostatic polypeptide and its preparation method and application. The structural formula of the chiral hemostatic polypeptide is shown in formula (I). The preparation method comprises: activation of resin, coupling of amino acids, excision and precipitation of polypeptide, and separation and purification of polypeptide. The chiral hemostatic polypeptide prepared by the present invention has good biocompatibility, does not cause inflammatory reaction at the wound site, has the function of binding calcium ions, and exhibits excellent effects in hemostasis and bone regeneration. #imgabs0#

The utility model belongs to the technical field of blood sampling application, and provides a pressing-free blood sampling application which comprises an adhesive tape and an elastic application plate, the two ends of the application plate are bent upwards to form pressing ends, clamping grooves are formed in the pressing ends, the two clamping grooves are clamped to the two sides of the adhesive tape, a limiting ring is arranged on the bottom face of the application plate, and the pressing-free blood sampling application is arranged on the bottom face of the application plate. And a matched hemostatic cotton paste is arranged in the limiting ring. After vein blood sampling is completed, a blood sampling worker presses a blood sampling point position with the application plate, the hemostatic cotton paste makes contact with the skin blood sampling position at the moment, then the films at the two ends of the pasting belt are torn off, the two ends of the pasting belt have viscosity, and the blood sampling worker slightly pulls the two ends of the pasting belt outwards and downwards to be pasted to the skin. The compression ends at the two ends of the application plate are deformed downwards to a certain degree, so that the application plate can generate continuous pressure downwards, the hemostatic cotton paste is pressed downwards through the application plate, the hemostatic effect is achieved, and no extra hand pressing for hemostasis is needed.

This application discloses an automatic inflatable tourniquet, comprising: a compression band defining a receiving cavity, the receiving cavity having an air inlet located outside the compression band; a cover structure covering the air inlet; a sealing plate slidably mounted on the cover structure, the sealing plate having a control valve capable of closing the air inlet; a drive structure mounted on the cover structure and connected to the sealing plate; a sensing structure mounted inside the compression band, the sensing structure being electrically connected to the drive structure; a filling structure configured to be compressed and filled within the receiving cavity; and a locking band for tightening the compression band. The drive structure drives the sealing plate to slide according to the sensing signal from the sensing structure, causing the control valve to be misaligned with the air inlet, allowing the receiving cavity to communicate with the atmosphere through the air inlet, thereby causing the filling structure to expand and apply pressure to the inside of the compression band. This automatic inflatable tourniquet does not require an air pump, is simple to operate, provides good compression, and can be operated with one hand, making it suitable for emergency hemostasis in field or battlefield environments.

The invention discloses a traditional Chinese medicine formula for treating epistaxis and other hemorrhagic diseases, and is characterized in that the traditional Chinese medicine formula comprises the following raw medicinal materials in parts by weight: 8g of folium artemisiae argyi, 8g of semen boitae, 8g of pulp of dogwood fruit, 8g of cortex moutan, 15g of radix rehmanniae, 10g of white lotus pulp and 10g of Chinese yam. According to the formula, the bleeding symptom can be effectively improved, the recovery of the blood coagulation function is promoted, and the self-repairing ability of the body is enhanced. The traditional Chinese medicine formula is natural, safe, small in side effect, convenient to prepare and take, suitable for being used for a long time and beneficial to improving the living quality and the treatment effect of patients.

The invention discloses a thrombin-modified hemostatic membrane and a preparation method thereof, and belongs to the technical field of hemostasis. The invention prepares a PAN-based PAN fiber membrane, and then performs carboxylation, amination, and itaconic acid cross-linking and activation on the PAN fiber membrane to obtain a surface-modified PAN fiber membrane with stable structure, and the surface-modified PAN fiber membrane can expose more active sites and bind with more thrombin. Thrombin is loaded on the surface-modified fiber membrane to obtain a thrombin-modified hemostatic membrane, and the thrombin-modified hemostatic membrane has good biocompatibility, can absorb blood or exudate in a short time, achieve the effect of rapid and long-term hemostasis, and can promote the growth and reproduction of adipose stem cells and human skin fibroblasts, promote cell regeneration, accelerate the healing of wounds, prevent secondary bleeding, and reduce the amount of bleeding.

The present invention discloses a processing method of a silk composite hemostatic airbag, including: baking a spunlace silk non-woven fabric, coating a melted medical hot melt adhesive on a release paper using an extrusion wire rod coater, pressing the baked silk non-woven fabric on the coating, cutting the silk non-woven fabric with the release paper according to a preset shape, pasting the silk non-woven fabric to the surface of a TPU hemostatic airbag, placing the hemostatic airbag inside a paper mold and inflating it, and adjusting the silk cutting edge on the inflated hemostatic airbag to align with the fold on the mold, evacuating the hemostatic airbag, and folding the mold and the airbag according to the mold fold, and obtaining a folded silk composite hemostatic airbag after unfolding the mold. The present invention adopts specific lines and divisions to fold the hemostatic airbag, which can ensure that the airbag can be inflated and unfolded more quickly, and at the same time, it will not rotate axially in a large range, causing secondary damage to the wound.

The invention provides an auxiliary hemostasis device for hemorrhagic skin mass laser treatment, and relates to the technical field of hemorrhagic skin treatment equipment. Comprising a hemostasis part and a fixing part, fixing belts are arranged on the two sides of the hemostasis part, and the fixing belts are detachably connected with the fixing part; a hemostasis pad is arranged on the hemostasis piece, an inflation strip is arranged on one side of the hemostasis pad, the two ends of the inflation strip are connected with the fixing bands on the two sides respectively, and an inflation opening is formed in the inflation strip; compared with the prior art, the structure is simple, the use is convenient, and hemorrhagic skin parts can be effectively compressed.

The invention relates to the technical field of daily chemicals, and aims to provide a skin care product for accelerating epidermal repair and a preparation method thereof. The skin care product disclosed by the invention is prepared from the following raw materials: dextrin / centella asiatica, ectoine, AQUAXYL, a seaweed extract, ceramide, triple helix collagen, bis-diethoxy diethylene glycol cyclohexane 1, 4-dicarboxylate, sodium hyaluronate, auxiliary components, water and the like. The skin care product for accelerating epidermal repair can effectively relieve damaged skin, adjust a skin water-oil balance system, deeply replenish water, nourish skin, effectively repair skin barrier and protect external stimulation.