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Degradable compound biomaterial membrane for medical purpose

A composite biomaterial and composite layer technology, which is applied in the field of degradable composite biomedical membrane and its preparation, can solve the problems of inflammation caused by acid accumulation, poor surgical anti-adhesion effect, unsatisfactory application effect, etc., and achieves favorable nutrient exchange. , Enhance the body's immunity, overcome the effect of acidic inflammatory response

Inactive Publication Date: 2007-07-11
BEIJING HUASHI BENQUAN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some fluid or semi-fluid anti-adhesion materials such as the polylactic acid anti-adhesion gel produced by Shijiazhuang Ruinuo Biomedical Materials Co., Ltd. and the "Jiantingning" agent produced by Yantai Wanli Medical Products Co., Ltd. are inconvenient to use. Some operations have poor anti-adhesion effects; in some solid diaphragm anti-adhesion materials, such as "Baifeimi" chitosan isolation film produced by Beijing Bailikang Biochemical Co., Ltd., and polylactic acid produced by Chengdu Dikang Zhongke Biomedical Materials Co., Ltd. Some films, etc. degrade too quickly, and some are easy to cause acid accumulation and cause inflammation, and they all lack adhesion to the body, are not easy to fix and difficult to operate, and the products have certain defects and one-sidedness in technology, and the application effect is not very ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare 10 milliliters of dichloromethane solutions of poly-DL-lactic acid with a viscosity-average molecular weight of 5000 at a concentration of 80% by weight, add 0.2 grams of polyethylene glycol with a molecular weight of 200, dissolve at room temperature for 12 to 20 hours, and then Spun into a film with a thickness of 0.01 mm by electrospinning, put it in an oven, and bake it at a temperature of 60 ° C for 5 to 8 hours. After drying for 7 hours, the total thickness of the film was 0.02 mm, and sterilized by Co-60 radiation to obtain a biodegradable composite biomaterial medical film.

Embodiment 2

[0022] Prepare 10 milliliters of dichloromethane solutions of poly-DL-lactic acid with a viscosity-average molecular weight of 10,000 at a concentration of 50% by weight, add 0.2 grams of polyethylene glycol with a molecular weight of 400, dissolve at room temperature for 12 to 20 hours, and then Spun into a film with a thickness of 0.01 mm by electrospinning, put it in an oven, and bake it at 60°C for 5 to 8 hours. After drying for 7 hours, the total thickness of the film was 0.02 mm, and sterilized by Co-60 radiation to obtain a biodegradable composite biomaterial medical film.

Embodiment 3

[0024] Prepare 10 milliliters of dichloromethane solutions of poly-DL-lactic acid with a viscosity-average molecular weight of 100,000 at a concentration of 7% by weight, dissolve at room temperature through stirring for 12 to 20 hours, and then spin into a film with a thickness of 0.07 mm through electrospinning. Put it into an oven and bake at 60°C for 5-8 hours. After taking it out, coat the pre-prepared 10% chitosan aqueous solution on the film, and dry it at a constant temperature of 20°C for 12 hours. The total thickness of the film is 0.1 mm, sterilized by Co-60 radiation to obtain a biodegradable composite biomaterial medical film.

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Abstract

The invention relates to a method for preparing composite biological medical material used to avoid adhering organisms, wherein said film is formed by two layers; the layer used as base material is formed by degradable composite macromolecule polylactic acid, glycolic acid, or their copolymer, treated by static spin technique, to make film fiber into nanometer level; then coats one layer of degradable natural macromolecule chitose or relative derivant on the base film, to be treated to obtain the degradable composite biological medical film; and the invention can add different amounts of medical elasticizer between two layers to adjust the degrade speed. The invention can improve immunity with haemostasis function, etc.

Description

1. Technical field [0001] The invention relates to a degradable composite biomedical film used for preventing tissue adhesion after operation and patching soft tissues of a human body and a preparation method thereof, belonging to the field of surgical medical materials. 2. Background technology [0002] Postoperative adhesion is one of the important problems that have not been well resolved at home and abroad since the history of surgery. With the development of medical technology, a variety of diseases can be completely cured after surgery, but it is easy to adhere between the wound surface and body tissues after surgery. Adhesion formation is characterized by resorption of neutrophils, macrophages, and subsequently fibroblasts, with local production of various cytokines and growth factors. Adhesions can not only cause serious complications, but also the most important reason for significantly increased complications during reoperation. In order to prevent tissue adhesio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/12A61L15/14A61L101/36A61L101/50
Inventor 侯光辉胡平侯梅
Owner BEIJING HUASHI BENQUAN TECH
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