61 results about "Synthetic Polymeric Macromolecules" patented technology

The invention discloses a biomass-based reinforcing agent for paper and application of the biomass-based reinforcing agent. The reinforcing agent comprises a biomass-based material, the biomass-based material comprises a micron-sized structure and a nano-sized structure distributed on the micron-sized structure. The reinforcing agent prepared by the invention has abundant nanostructures, is beneficial to physical crosslinking such as entanglement and bridging of fibers in paper pulp, and improves the wet strength of paper; the preparation of the reinforcing agent is a simple physical process, and a complex synthesis chemical process for synthesizing a polymer in a traditional organic reinforcing agent is avoided; the reinforcing agent is prepared by a dissolution regeneration method, so that the energy consumption is low, the solvent can be recycled and reused, no chemicals are consumed, and the reinforcing agent is environment-friendly; the reinforcing agent prepared by the invention can achieve a satisfactory wet strength effect at a lower content.

The invention discloses a method for in-situ rapid growth of a dual-network hydrogel coating on the surface of a base material by a one-step method, which comprises the following steps: putting the base material with an adhesion initiation layer on the surface into a hydrogel precursor solution, and carrying out in-situ polymerization for 0.1-10 minutes under light irradiation, wherein the adhesion initiation layer comprises an adhesive compound based on a catechol group and a first photoinitiator, and the hydrogel precursor solution comprises a natural polymer containing tyrosine, an acrylic monomer, a cross-linking agent and a second photoinitiator, and wherein the first photoinitiator and the second photoinitiator are different from each other and are independently selected from a divalent ruthenium compound and a persulfate. Compared with the prior art, the natural / synthetic polymer double-network gel coating with biological activity and mechanical property can grow on the surfaces of different substrates more quickly and efficiently through a one-step method; and the base material, the surface of which is modified by the in-situ grown double-network hydrogel coating, obtained by the method can be applied to in-vivo medical apparatuses and instruments.

The invention provides temperature-sensitive enhanced composite hydrogel as well as a preparation method and application thereof. The temperature-sensitive enhanced composite hydrogel is prepared from the following raw materials: a triblock copolymer, hydroxybutyl chitosan and an aqueous medium. According to the invention, the synthetic polymer material and the natural biopolymer derivative are compounded, so that the defects of a single-component material are overcome, the mechanical strength and stability of the hydrogel are remarkably improved, and the prepared hydrogel has good biocompatibility and degradability.

The application discloses an anti-bending artificial blood vessel, which comprises an artificial blood vessel inner layer, a synthetic polymer anti-bending ring and an artificial blood vessel outer layer; the artificial blood vessel inner layer is a synthetic polymer tube body; the artificial blood vessel outer layer is a synthetic polymer fiber membrane; the shape of the synthetic polymer anti-bending ring is a non-equidistant spiral structure; the synthetic polymer anti-bending ring is wound on the outer wall of the artificial blood vessel inner layer, is between the artificial blood vessel inner layer and the artificial blood vessel outer layer, and is fixed by being covered by the artificial blood vessel inner layer and the artificial blood vessel outer layer. The application further discloses a preparation method of the artificial blood vessel. The application can make the artificial blood vessel to be bent by 180 degrees in a full ring without flat collapse and kinking, can ensure that the whole artificial blood vessel has good anti-bending performance, can effectively improve the anti-bending performance of the artificial blood vessel, and can effectively improve the compliance of the artificial blood vessel.

This invention relates to the field of biomedical polymer materials and surface modification engineering, specifically to a posterior scleral reinforcement material and its preparation method. It comprises a polymer matrix and a bioactive modified layer formed by the oxidative crosslinking of a heterobifunctional polymer coupling compound. This copolymer structure includes anchoring groups, hydrophilic linkers, and bioactive groups. Its core principle is to utilize the flexible extension of the hydrophilic linkers to reduce steric hindrance, fully exposing the bioactive groups to the material surface, thereby achieving efficient recognition and binding to integrin receptors. This invention effectively solves the problems of bioinertness of the synthesized polymer matrix and lack of cell recognition sites, achieving a cell proliferation rate more than twice that of the unmodified matrix, demonstrating the material's excellent bioactivity and cell compatibility.

The invention discloses a sealant with bacteriostatic and mildew-proof functions for a metal bottle cap and a preparation method of the sealant, and belongs to the technical field of sealant preparation. The sealant provided by the invention is prepared from the following raw material components in percentage by mass: 40.0 to 55.0 percent of an auxiliary agent A, 0.5 to 3.0 percent of an auxiliary agent B, 2.0 to 4.0 percent of zinc stearate, 1.0 to 3.0 percent of titanium dioxide, 1.0 to 5.0 percent of ground calcium carbonate, 0.5 to 2.5 percent of an anti-blocking agent and 39.0 to 55.0 percent of polyvinyl chloride resin, the auxiliary agent A is prepared from at least two of dioctyl terephthalate, epoxidized soybean oil, trimellitic anhydride and cyclohexane 1, 2-diisononyl diformate; the auxiliary agent B is obtained by mixing and grinding zinc oxide, metal silver, zirconium phosphate, zinc pyrithione and coconut oil fatty acid diacetamide. According to the invention, the sealant is prepared by compounding multi-component food-grade antibacterial mildew-proof active components, so that the prepared sealant is ensured to reach the first-grade standard of ASTM G21-15 Determination of Antifungal Factor of Synthetic High Polymer Materials, meanwhile, the risk that the sealant is mildewed when being used in canned food is reduced, and the quality of the product is improved.

The invention discloses a composite artificial cavity / membrane tissue and a preparation method thereof. The composite artificial cavity / membrane tissue is formed by compounding a synthetic high-molecular material and a natural high-molecular biological material, and the synthetic high-molecular material is selected from more than one of silicone, synthetic high-molecular hydrogel and an acrylic polymer. The natural polymer biological material is selected from more than one of an acellular matrix scaffold material, a non-acellular matrix and non-acellular collagen. The composite artificial cavity / membrane tissue provided by the invention has the advantages of good healing after transplantation, high biomechanical strength, low immunogenicity, smooth surface and the like.

The present application belongs to the field of cosmetics, and relates to a kind of refreshing essence containing fluorine and a preparation method thereof.The essence includes the following mass percentage components: oil phase (0.01-15) %, fluorine-containing organic compound phase (1-15) % and water phase (80-90) %, wherein the water phase contains natural polymer and synthetic polymer and deionized water in remainder.Compared with the prior art, the present application uses high molecular polymer instead of emulsifier to disperse and stabilize oil, makes the essence material body uniform, avoids the sticky feeling and possible irritation caused by the use of emulsifier, and uses fluorine-containing organic compound instead of part of oil.Compared with the use of oil alone, the addition of fluorine-containing organic compound is equivalent to diluting the oil, reducing the amount of oil used, making the product more refreshing, and not losing the moisturizing feeling.

The invention relates to the technical field of biological tissue engineering, in particular to injectable amnion compound gel as well as a preparation method and application thereof. The problems that an existing material is non-adjustable in degradation and mechanical property, amnion particles are prone to displacement and sedimentation, cell loading is insufficient, and repairing is not long-acting are solved. Comprising a composite stent membrane and aldehyde hyaluronic acid gel in a mass ratio of 1: (3-10), and the membrane is formed by freeze-drying and grinding a composite stent; the stent comprises an upper electrostatic spinning fiber membrane layer, a decellularized amnion matrix middle layer and a lower electrostatic spinning fiber membrane layer which are sequentially stacked and are crosslinked and combined into a whole; electrostatic spinning fibers in the upper electrostatic spinning fiber membrane layer and the lower electrostatic spinning fiber membrane layer are of core-shell structures, and raw material components of shell layers comprise natural high polymer materials; the core raw material component comprises a synthetic high polymer material. The preparation method comprises the following steps: preparing the decellularized amniotic membrane matrix, constructing the gradient fiber membrane layer through coaxial electrostatic spinning, cross-linking tannic acid, freeze-drying and grinding, and preparing and compounding formylated hyaluronic acid gel.

The invention provides a compound preparation containing macarovir, a preparation method and application of the compound preparation in anti-influenza treatment, the multi-layer pellet compound preparation sequentially comprises a pellet core layer containing macarovir, an isolating layer, an active layer and an enteric layer from inside to outside, the pellet core layer containing macarovir and a sustained-release material, the isolating layer comprises an adhesive and an anti-sticking agent, the active layer comprises a hydrophobic layer and a hydrophobic layer, and the enteric layer comprises a hydrophobic layer and a hydrophobic layer. The active layer comprises oseltamivir phosphate and an adhesive, and the enteric-coated layer is made of synthetic polymer materials. The multi-layer pellet provided by the invention has good compressibility, disintegrability and lubricity. The compound preparation solves the problems of drug resistance, drug interaction and children medication compliance. The preparation is suitable for single-drug or combined treatment of influenza A / B viruses, and is especially suitable for children and drug-resistant influenza patients.

The invention provides a pH and redox dual-responsive cryogel material and a preparation method and application thereof, and the pH and redox dual-responsive cryogel material is prepared by modifying a natural polymer or a synthetic polymer grafted hydrazide and an aldehyde group with biocompatibility, and condensing the hydrazide and the aldehyde group into a reversible dynamic covalent bond acylhydrazone bond at low temperature. The shape memory crystal gel for quickly stopping bleeding is formed. The cryogel generates gel-sol change in an acid environment, disulfide bonds can be broken under the action of a reducing agent, and material removal and wound cleaning after hemostasis are facilitated. The cryogel material provided by the invention is low in raw material price, simple in process, good in biocompatibility and obvious in pH responsiveness, forms a physical barrier to block a bleeding wound after being in contact with blood, and is easy to remove after being dissolved in an acid environment.

The invention relates to a polyesteramide copolymer as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The polyesteramide copolymer is prepared by the following preparation method: heating hydroxy acid, amino acid and caprolactam in the presence of a catalyst, and carrying out ring opening-condensation cascade polymerization to obtain the polyesteramide copolymer. The preparation method disclosed by the invention can be used for synthesizing the polyesteramide copolymer with high molecular weight and high performance in one step, and the polyesteramide copolymer has higher strength, toughness, elongation at break and good biodegradability, and has wide application prospects in the fields of engineering plastics, drug delivery, automobile accessories and the like.

The application discloses a kind of essence microcapsules for candle and preparation method.The microcapsule includes capsule core and capsule wall, the capsule core is essence, and the capsule wall is formed by natural polymer material (such as gelatin, gum arabic) and synthetic polymer material (such as polyurea, polyamide) compound, and the essence content in capsule core is 20%-60% of the total weight of microcapsule.The preparation method is to prepare natural polymer solution and synthetic polymer solution respectively, add essence into natural polymer solution to obtain mixed solution, then drop synthetic polymer solution into mixed solution and stir to form emulsion, then adjust the pH value of emulsion to make capsule wall material polymerization to form microcapsule, and finally, after washing and drying, the finished product is obtained.The microcapsule of the application can effectively protect the essence, can accurately control the release speed of the essence, prolong the candle fragrance time, and the preparation process is simple, convenient to operate, easy to scale production, which provides a better solution for the application of candle essence, and has good application prospect in candle manufacturing field.

Some embodiments of the disclosure provide a polymer film used for a biosensor. The polymer film has a three-dimensional network structure formed by a natural high-molecular polymer and a synthetic high-molecular polymer by a plurality of crosslinking modes. The three-dimensional network structure includes a chemically crosslinked network and a reversible physically crosslinked network, the chemically crosslinked network being formed by covalent bond crosslinking and the reversible physically crosslinked network being formed by ionic bond crosslinking. The chemically crosslinked network has covalent bond crosslinking between the synthetic high-molecular polymers and covalent bond crosslinking between the natural high-molecular polymer and the synthetic high-molecular polymer. The physically crosslinked network has ionic bond crosslinking between natural high-molecular polymers.

The invention discloses a photo-thermal self-healing drug-loaded microneedle patch and a preparation method and application thereof, and belongs to the technical field of transdermal drug delivery. Firstly, an initial needle body is prepared from a synthetic high polymer material, photo-thermal nano-particles and a first solvent, after the initial needle body and a substrate prepared from a curable material are combined and cured, low-temperature treatment is conducted, and a drug-loaded microneedle patch is obtained; the preparation method comprises the following steps: preparing a first solvent and a second solvent, demolding to obtain a preformed micro-needle patch, immersing the preformed micro-needle patch into the second solvent, carrying out solvent replacement on the first solvent and the second solvent, drying to obtain a porous micro-needle patch, dropwise adding a vaccine solution or a drug solution to the surface of a needle body of the porous micro-needle patch, and enabling a vaccine or a drug to enter the needle body in a vacuum-assisted manner to obtain the porous micro-needle patch. And after drying, applying near-infrared light to irradiate, and accelerating the closing of the holes of the needle body based on a photothermal effect to obtain the photothermal self-healing drug-loaded microneedle patch. The invention provides an efficient, stable and controllable novel delivery platform for the fields of vaccine delivery, immunotherapy, transdermal delivery of biological agents and the like.

The invention provides a method for adsorbing and removing perfluoro and polyfluoroalkyl compounds in water, plastic particles are used as an adsorbent, the perfluoro and polyfluoroalkyl compounds in water are removed by a batch adsorption method or a fixed bed adsorption method, and the chain length of the perfluoro and polyfluoroalkyl compounds is not less than 4 carbon atoms. The plastic particles are made of synthetic high-molecular polymer particles. According to the method, waste plastic particles which are wide in source and low in cost are adopted as the adsorbent, and efficient removal of PFAS in water can be achieved. Meanwhile, the method for removing the PFAS in the water based on the waste plastic particles serving as the adsorbent is adopted, so that the environmental accumulation and pollution risks possibly caused by the solid wastes are avoided, and the synergistic target of resource utilization of the waste plastic particles and efficient removal of the PFAS in the water is also achieved.

The present application addresses the problem of providing a carbon material precursor having, as a main component, cellulose-based fibers that are sustainable biomass resources, the precursor having little shrinkage due to carbonization treatment. The present invention also addresses the problem of providing a method for producing a carbon material that is capable of suppressing shrinkage due to carbonization even when a precursor having cellulose-based fibers as the main component is used. A carbon material precursor is prepared from an unfired fiber mixture containing cellulose fibers and synthetic polymer fibers, the content of the cellulose fibers in the unfired fiber mixture being 50% by weight or more, and the content of the synthetic polymer fibers in the unfired fiber mixture being 5% by weight or more but less than 50% by weight. The synthetic polymer fibers have a higher thermal decomposition temperature than the thermal decomposition temperature of the cellulose-based fibers and do not melt at or below the thermal decomposition temperature of the cellulose-based fibers. A carbon material is obtained by firing such a carbon material precursor.

The invention relates to the technical field of synthetic high polymer materials, and particularly discloses an anacaric acid-based liquid mulching film and a preparation method thereof.The preparation method comprises the following steps that S1, anacaric acid and an emulsifier are weighed respectively, stirred and mixed, water is dropwise added, anacaric acid emulsion is formed, a proper amount of preservative is added, and a component A is prepared; s2, taking a polyurethane dispersion, humic acid, a chain extender and a dispersing agent, adding water, stirring and mixing to prepare a component B; s3, mixing the component A and the component B, adding a proper amount of water, and uniformly stirring to obtain the anacaric acid-based liquid mulching film. The liquid mulching film with the plant anacaric acid as the main raw material can be widely applied to the field of agricultural production, can be uniformly sprayed on the crop surface to form a layer of protective film on the soil surface, can effectively bond soil particles, and has multiple effects of preserving soil moisture, increasing temperature, supplementing fertility and the like, so that the growth environment of crops is remarkably improved, and the yield is increased.

The invention discloses a concrete structure steel bar pre-embedded connector device and a using method thereof.The concrete structure steel bar pre-embedded connector device comprises a plurality of splicing units, four concave-convex mortise and tenon notches are formed in the two sides of each splicing unit, and the adjacent splicing units are spliced in a butt joint mode through the mortise and tenon notches to form a device body with the length matched with the construction requirement; the device body is made of synthetic polymer plastic materials, detachable reserved connector notches are formed in the upper portion and the lower portion of the device body, bolt holes are formed in the notches, the notches are fixed and disassembled through bolts, rapid assembly and flexible disassembly and assembly are achieved, and the material turnover rate is increased. According to the invention, a synthetic polymer plastic material is used as a carrier, and the carrier is shaped, is provided with a height adjusting device, and can adapt to structures with different section heights. The material has the characteristics of light weight, high strength, good sealing performance, wide applicability, high turnover rate and the like. After the structural slab steel bars are installed, the structural slab steel bars can also serve as side formworks of the structural slab, connector hole sites are reserved in the surfaces, and the embedded connectors can be directly placed in the connector hole sites after the connector hole sites are fixed.

The invention belongs to the technical field of cosmetics, and discloses a synergistic thickening moisturizing composition and application thereof in cosmetics. The composition comprises polyquaternium-51 and a synthetic polymer thickening agent. According to the invention, the polyquaternium-51 and the synthetic polymer thickening agent are compounded for the first time, the obtained composition is efficiently and synergistically thickened in cosmetics, the thickening or gelation requirement of the product is easily met, the problem that the skin is thick and sticky due to addition of multiple types of thickening agents is avoided through the matching of the single thickening agent and the humectant, and the skin care effect is good. According to the present invention, the composition provides the refreshing and smooth skin feeling for the product, can provide the excellent moisturizing power for the product, further provides the good suspension and emulsification stabilization effects in the cosmetics, can improve the long-term stability of the product, can reduce the use amount of the surfactant, and can make the system milder. The synergistic thickening moisturizing composition is applied to cosmetics and has a good application prospect.

The invention discloses a compound paracetamol and amantadine hydrochloride capsule containing caffeine microcapsules, which relates to the technical field of medicines and comprises paracetamol, amantadine hydrochloride, calculus bovis factitius, pharmaceutic adjuvants and functional microcapsule units. The functional microcapsule unit has a three-layer structure: a core material taking caffeine and microcrystalline cellulose as a core, an ethyl cellulose controlled release layer and a quick release layer containing chlorpheniramine maleate. According to the structure, time sequence controlled release of drugs is achieved by synthesizing a polymer coating material, chlorpheniramine maleate is quickly released when encountering gastrointestinal fluid to quickly resist allergy, and caffeine starts to be slowly released after being effectively delayed to the intestinal environment, so that the time when the plasma concentration reaches the peak tends to be synchronous with the time when chlorpheniramine maleate reaches the peak; the drowsiness side effect can be effectively resisted.

This invention relates to the field of bio-tissue engineering technology, and particularly to an injectable amniotic membrane compound gel, its preparation method, and its application. It addresses the problems of degradation and unadjustable mechanical properties of existing materials, easy displacement and sedimentation of amniotic membrane particles, insufficient cell loading, and short-lasting repair effects. The gel comprises a composite scaffold membrane and an aldehyde-based hyaluronic acid gel in a mass ratio of 1:3 to 10. The membrane is formed by freeze-drying and grinding the composite scaffold. The scaffold comprises a sequentially stacked upper electrospun fiber membrane layer, a decellularized amniotic membrane matrix intermediate layer, and a lower electrospun fiber membrane layer, cross-linked and bonded together. The electrospun fibers in the upper and lower electrospun fiber membrane layers have a core-shell structure. The shell layer raw material components include natural polymer materials, and the core raw material components include synthetic polymer materials. The preparation method includes preparing a decellularized amniotic membrane matrix, constructing a gradient fiber membrane layer through coaxial electrospinning, cross-linking with tannic acid, freeze-drying and grinding, and preparing and compounding the aldehyde-based hyaluronic acid gel.

The invention discloses a polyaluminum chloride-plant extract composite flocculant as well as a preparation method and application thereof, and belongs to the technical field of sludge resource utilization. The preparation method comprises the following steps: mixing dry okra powder and dry banana peel powder according to a specific ratio, adding a sodium chloride solution for ultrasonic extraction, filtering, concentrating to obtain a plant extracting solution, and compounding the plant extracting solution with polyaluminum chloride according to a specific ratio. According to the invention, polyaluminum chloride is adopted to replace a traditional toxic synthetic polymeric flocculant, and carboxylic acid in the extract and polyaluminum chloride are utilized to generate a synergistic effect, so that a flocculation effect equivalent to that of polyacrylamide is realized, and meanwhile, the problems that the synthetic polymeric flocculant is residual in toxicity, difficult to degrade and difficult in sludge resource utilization are solved.

Provided is a method for using a phenothiazine derivative compound, in which, in a synthetic polymer material produced by addition polymerization of a polymerizable unsaturated monomer, the polymerizable unsaturated monomer constituting the material is copolymerized with a phenothiazine derivative compound represented by general formula [I] in order to prevent oxidative degradation of the synthetic polymer material. The compound can be copolymerized with various polymerizable unsaturated monomers because the specific polymerization inhibition effect of the phenothiazine compound is reduced. In the general formula [I], R1 is a monovalent aliphatic hydrocarbon group having 1-10 carbon atoms, and R2 is a hydrogen atom or a methyl group.

The invention discloses body temperature responsive self-adhesive gel microspheres as well as a preparation method and application thereof, and relates to the technical field of medicines. The body temperature responsive self-adhesive gel microspheres comprise a photocuring structure stabilizing unit material and a body temperature responsive self-adhesive unit material; the photocuring structure stable unit material comprises at least one of a natural polymer derivative material and a synthetic polymer material; the body temperature responsive self-adhesive unit material can be subjected to chain segment migration and re-entanglement at a physiological temperature. The gel microsphere has good temperature-controlled self-adhesion capability and interface adhesion property, and can be used as an embolism agent for treating vascular embolism.

The invention relates to a porcine lymph node acellular extracellular matrix pregel aqueous solution which comprises a porcine lymph node acellular extracellular matrix with the mass fraction of 0.1%-5% and the balance ultrapure water or a cell culture medium. The preparation raw material of the pig lymph node acellular extracellular matrix is pig lymph nodes. The invention also relates to a composite hydrogel which is prepared by mixing a pre-gel aqueous solution and a polymer solution according to a volume ratio of 1: 1-1: 3, the pre-gel aqueous solution comprises a pig lymph node acellular extracellular matrix with the mass fraction of 0.1%-5% and the balance of ultrapure water or a cell culture medium; preferably, the preparation raw material of the pig lymph node acellular extracellular matrix is pig lymph nodes; the high-molecular solution is a natural high-molecular polymer solution or a synthetic high-molecular polymer solution with the mass fraction of 1%-10%, and a high-molecular polymer is selected from one or more of hyaluronic acid, collagen, gelatin, matrigel, chitosan, silk fibroin, polylactic acid, polyethylene glycol, polyvinyl alcohol, alginate and derivatives thereof.

The invention relates to the technical field of synthetic high polymer material processing, and discloses synthetic polyisoprene gasket processing equipment and a preparation process thereof.The synthetic polyisoprene gasket processing equipment comprises a bottom plate, by integrating multiple processing procedures, integrated continuous processing is achieved, a transfer mechanism and manual transfer are omitted, the surface of a gasket is prevented from being scratched and polluted, and the product percent of pass is increased. Continuous processing greatly shortens the processing period, compared with traditional distributed equipment, the production efficiency is remarkably improved, meanwhile, manual operation is reduced, the labor intensity and the labor cost are reduced, the large-scale production requirement is met, in the rubber extrusion and sheet blank vulcanization process, a roll shaft can be automatically coated with a release agent, the situation that a synthesized polyisoprene material adheres to the equipment is avoided, and the production efficiency is improved. The machining equipment is simple in structure, convenient to operate, capable of reducing material waste, convenient to clean and maintain, capable of reducing the fault occurrence rate, capable of adjusting machining parameters according to needs and suitable for machining synthetic polyisoprene gaskets of different sizes and thicknesses, greatly reducing enterprise equipment investment and improving the equipment utilization rate.

The application discloses a multi-mode display layer made of up-conversion liquid crystal microcapsules and display application, the display layer is coated by optical ink containing up-conversion liquid crystal microcapsules, the up-conversion liquid crystal microcapsules include core material, and the capsule wall covering the core material, the core material is cholesteric liquid crystal doped with photosensitizer and luminous agent, and the structural color of the cholesteric liquid crystal can be adjusted, and the capsule wall is synthetic polymer material or natural polymer material; the display layer has three display modes, namely, the reflection light mode under the bright field, the structural color of the cholesteric liquid crystal is presented; the fluorescent mode under UV, the fluorescent color of the luminous agent is presented; and the up-conversion luminescence mode under laser, the up-conversion luminescence color of the photosensitizer and the luminous agent being excited is presented. The multi-mode display layer made of up-conversion liquid crystal microcapsules can be applied in the field of anti-fake display and information encryption.

The present application relates to a kind of polymer composite microcarrier and its preparation method.It includes: microcarrier body, the microcarrier body includes synthetic polymer, the microcarrier body is hollow structure, the axial length of the microcarrier body is greater than the radial length of the microcarrier body;Functional area, the functional area is microporous structure, the functional area is formed on the microcarrier body, and the functional area includes natural macromolecule, or, the functional area includes natural macromolecule and inorganic salt.The polymer composite microcarrier of the present application can make cell adhere to the outer surface of hollow microcarrier, and the internal hollow structure can facilitate the flow of liquid, provide uniform, good microenvironment for large-scale expansion of cell, it is advantageous to improve the number of cell expansion.

The invention discloses a three-dimensional senescence cell model and a construction method and application thereof, and relates to the technical field of cell model construction.The method comprises the steps that after cells are subjected to two-dimensional culture, a cell suspension is prepared; the preparation method comprises the following steps: mixing methacryloyl gelatin, human I-type collagen, a photoinitiator and a synthetic high-molecular polymer in a PBS (Phosphate Buffer Solution) to prepare bio-ink; the synthetic high-molecular polymer is obtained by mixing 3-aminophenylboronic acid grafted sodium alginate and methylacryloylated sodium alginate; mixing the obtained bio-ink with a cell suspension, and performing three-dimensional printing to obtain a cell model; and performing oxidative stress condition treatment, cleaning and culture on the obtained cell model to obtain the three-dimensional senescence cell model. According to the invention, a three-dimensional biological printing technology mode is adopted, and an aging cell model with a three-dimensional structure is constructed. The three-dimensional fibroblast aging model established by the invention is real and reliable, and supports are provided for subsequent in-depth research on aging mechanisms, screening of anti-aging drugs, research and development of new drugs and the like.