48 results about "Multi resistant bacteria" patented technology

The invention relates to novel methods for using macrolide anti-infective agents. The macrolide anti-infective agents demonstrate antibacterial activity against multi-drug resistant strains of bacteria and, in particular, methicillin-resistant Staphylococcus aureus (MRSA). Methods for inhibiting the activity of multi-drug resistant bacterial organisms and methods for treating a bacterial infection caused by such organisms are described herein.

The present invention relates generally to an antibacterial coating which is composed of silver, to medical tools and to implants comprising such a coating and to a method as well to an apparatus for the production of such a coating. The medical tools or the dental or orthopaedic implant comprises a metal or metal alloy having a treated surface wherein the treated surface is at least partially converted to an oxide film by plasma electrolytic oxidation using a colloid-dispersed system and wherein the converted surface is partially covered by islands formed by colloid-dispersed silver-particles of the colloid-dispersed system. An Ag—TiO2 coating shows excellent properties in terms of antibacterial efficacy (even against multi-resistant strains), adhesion and biocompatibility. The life-time of an implant in a human body is increased. The antibacterial coating can be used in the field of traumatology, orthopaedic, osteosynthesis and / or endoprothesis, especially where high infection risk exists.

The invention provides a group of peptide nucleic acid-cell penetrating peptide antisense antibacterial sequences taking bacterial gene rpoD as a target. The cell penetrating peptide-mediated antibacterial RNA polymerase sigma 70 factor gene rpoD which is antisense nucleic acid of a specificity target can selectively inhibit the expression of in-vivo ropD genes of Gram-negative bacterium (containing sensitive and multidrug resisting clinical pathogenicity Escherichia coli, salmonellatyphimurium, Klebsiella pneumoniae and pseudomonas aeruginosa) or gram-positive bacterium (containing sensitiveand multidrug resisting staphylococcus aureus) and further inhibit bacteria growth and reproduction, thus having the advantages of good antibacterial effect, low toxicity, good stability and better tolerance. The invention also discloses a chemical preparation method of a peptide nucleic acid-cell penetrating peptide solid phase. The antibacterial peptide synthesized in the invention can be used for preparing multidrug-resistant bacteria infection proofing antisense drugs and has the potency of being developed into a broad-spectrum antisense antibacterial agent which is expressed by efficiently transferred and peculiarly blocked bacterium disease-causing genes.

The invention discloses lactic acid bacteria strains capable of inhibiting multiple drug-resistant food-borne pathogenic bacteria in a broad-spectrum manner and an application of the lactic acid bacteria strains. The strains have functions of inhibiting the activity of multiple drug-resistant bacteria and food-borne pathogenic bacteria in a broad spectrum manner, and are named as lactobacillus plantarum GS083, lactobacillus plantarum GS086, lactobacillus plantarum GS090 and lactobacillus fermentum GF110. The lactic acid bacteria strains provided by the invention has a very good bacteriostaticeffect on multiple drug-resistant bacteria and food-borne pathogenic bacteria, and can inhibit gram-negative bacteria and gram-positive bacteria; the strains also have the characteristics of bile salthydrolase activity, acid resistance, bile salt resistance, low drug resistance, no hemolysis, no toxicity gene and the like, enrich the lactobacillus strain resource library, and have wide application prospects in the industries of food, cosmetics, medicines and the like.

The present invention relates to an antimicrobial peptide having an improved antibacterial effect through glutamic acid substitution and, more specifically, to a use of the antimicrobial peptide as an active ingredient in an antibacterial pharmaceutical composition, a food additive, a feed additive, an antiseptic composition, and an antibacterial quasi-drug composition. Not only does the antimicrobial peptide of the present invention exhibit significant antibacterial activity against gram-negative bacteria, but it also exhibits a significant synergistic effect when combinedly treated with antibiotics which have strong antibacterial activity only against gram-positive bacteria and has no or low antibacterial activity against gram-negative bacteria, thereby exhibiting excellent antibacterial effects on gram-positive bacteria, E. coli and Acinetobacter bacteria among gram-negative bacteria, and antibiotic-resistant strains thereof.

The invention discloses an application of vitamin K3 in preparation of drug for treating bacterial and multiple resistant bacterial infection. By means of a CLSI standard method, research to anti-bacterial activity and anti-multiple-resistant-bacterial activity of the vitamin K3 is carried out with a result proving that: the vitamin K3 has significant inhibiting effect on growth of all test bacterial strains, which means that the vitamin K3 is significant in anti-bacterial activity and anti-multiple-resistant-bacterial activity and shows that the vitamin K3 is excellent in application and development prospect. The vitamin K3 can be used for preparing the drug for treating the bacterial and multiple resistant bacterial infection.

The invention discloses Chinese housefly antibacterial peptides 1 and a method for separating and purifying the same. The Chinese housefly antibacterial peptide 1 comprises five peptide segments. The method for separating and purifying the Chinese housefly antibacterial peptides comprises the following steps of: 1, performing immune induction of houseflies; 2, performing tissue homogenate of immune-induced houseflies to obtain sample solution containing antibacterial peptides; 3, performing dialysis concentration of the sample solution to obtain a concentrated sample; 4, performing ultra-centrifugal filtration of the concentrated sample to obtain the semi-purified antibacterial peptides; and 5, performing HPLC separation and purification of the semi-purified antibacterial peptides to obtain Chinese housefly antibacterial peptides with pure chromatograph. The Chinese housefly antibacterial peptide 1 of the invention is a micromolecular peptide newly found, the activity of the antibacterial peptide is higher, and the Chinese housefly antibacterial peptide 1 is a novel antibacterial medicament which has development potential and can resist multiple resistant bacteria.

The invention relates to a kind of intestinal mucosa damage restoring agent as well as preparative method. It has solved many defects of traditional method such as no obvious therapeutic efficacy of digallic acid soybean protein to diarrhea caused by bacteria, fungus, virus, toxins and parasites, the increase of drug resistant strain and multidrug resistant strain, the increase of chemical resistance and drug tolerance of pathogenic bacteria. The product in the invention contains 15-100% (by weight) of digallic acid antimicrobial active protein. The preparing method of the invention: adopting digallic acid to load antimicrobial active protein. The total efficiency of the agent can reach 100%, the diarrhea symptoms of patients can be substantially released after 1 day of taken the medicine, after 2-3 days, the cure rate can reach 85% or more. The yield of the antimicrobial active protein in the invention is 80% or higher by weight.

Disclosed is pollution-free functional water with deodorization activity and sterilization activity against multi-drug resistant bacteria. In the present invention, the functional water is prepared by treating a solution which contains mixture of pulverized molasses, soybean and bamboo through decomposition tank, a first precipitation tank, a bio-tank, a second precipitation tank and filter. Also, disclosed in a method for preparing the functional water.

The invention relates to a small peptide resisting MDR (multiple resistant bacteria). The small peptide is characterized in that the small peptide has the function of resisting clinically isolated MDR. In-vitro activity assay results prove that 11 small peptides have different antibacterial activities for multiple MDR and have the MIC value ranging from 4 mu g / L to 128 mu g / L according to different bacteria. Compared with a mother pattern, the small peptide has enhanced pseudomonas aeruginosa and candida albicans resistant activity. 6 peptides with better antibacterial activity are selected for an in vivo experiment, results prove that the 6 peptides can notably reduce the death rate of a model mouse because of a pseudomonas aeruginosa standard strain and clinical pan-drug-resistant pseudomonas aeruginosa septicemia and have a synergistic effect with polymyxin; no hemolytic reaction is caused when the concentration of 6 small peptides is 10 mg / ml, and the product safety is higher; local stimulation experiment results of rabbit eye conjunctiva show that the small peptide has no acute toxic stimulus reaction.

The invention belongs to the technical field of medicine, and particularly relates to application of hypoxanthine nucleotide in preparation of anti-infective drugs. Experiments prove that the hypoxanthine nucleotide can significantly improve the sensitivity of Escherichia coli, Klebsiella pneumoniae, staphylococcus aureus multi-drug-resistant bacteria, pseudomonas aeruginosa and other bacteria toamoxicillin, cefoperazone, meropenem, gentamicin and other antibiotics, so that the hypoxanthine nucleotide can be used as an anti-infective drug together with antibiotics. Bacteria are killed under the condition of low-concentration antibiotics, a good anti-infection effect is achieved, and meanwhile bacterial drug resistance is reduced.

The invention relates to an organic boron photosensitizer based on aggregation-induced emission, a preparation method thereof and application of the organic boron photosensitizer in photodynamic therapy for multi-drug-resistant bacterium infection. A series of synthesized organic boron photosensitizers based on aggregation-induced emission are easy to synthesize, show good aggregation-state luminescence and active oxygen generation characteristics, are used as photosensitizers for labeling and photodynamic therapy of multi-drug-resistant bacterium infection, and have very important significance and value in the technical field of biological medicines.

The invention relates to an imbibition controlled-release antibacterial peptide hydrogel double-layer dressing as well as a preparation method and an application thereof, and belongs to the field of biomedical materials. The hydrogel double-layer dressing comprises an antibacterial peptide controlled-release hydrogel layer and an imbibition gel layer. A chitosan gel film serves as an imbibition material to be used in the drug dressing for absorbing wound infection exudate for the first time, the exudate self-adjusting effect is achieved, and the upper antibacterial peptide hydrogel release layer controls continuous release of antibacterial peptide proSP-B. Therefore, multiple drug-resistant bacteria such as MRSA at the wound are inhibited in a long-acting manner, and wound infection healing is accelerated.

Infections caused by Mycobacterium tuberculosis kill more than 1.8 million people each year. While the persistence of this pathogenic bacterial species and the emergence of multidrug resistant strains have created an urgent need for new TB therapies, a new TB-specific drug has not been developed in over 40 years. The disclosure herein provides short and scalable syntheses of small molecules, and small molecules as new therapeutics for eradicating this life threatening pathogen.

A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof, and the use thereof to prevent or treat infectious diseases and a method to prevent or treat infectious diseases using those regimen are disclosed. The compound represented by formula (I) has an antibacterial activity against both gram-positive and gram-negative bacteria, and is useful in the prevention or treatment of infectious diseases caused by these bacteria.

The present invention provides the use of a molybdenum and / or tungsten-containing compound in resisting human papilloma virus (HPV) or herpes virus (HSV). As an antiviral substance, the compound containing molybdenum and / or tungsten can quickly kill and permanently inhibit pathogenic microorganisms (bacteria, viruses and molds) and multi-drug-resistant bacteria; the traditional Chinese medicine composition can be used for treating and relieving various symptoms caused by human papilloma virus HPV and herpes virus HSV, and has the advantages of quick effect and strong disinfection activity, and the antiviral substances are not absorbed by the human body and do not generate toxic and side effects; the compound can be used for reducing the load of local human papilloma virus (HPV) and herpes virus (HSV) of a human body, and can also be used for preparing medicines, medical instruments, disinfectants and other auxiliary nursing products for treating various human skin or skin mucosa diseases caused by pathogenic microorganisms.

The invention relates to a kind of intestinal mucosa damage restoring agent as well as preparative method. It has solved many defects of traditional method such as no obvious therapeutic efficacy of digallic acid soybean protein to diarrhea caused by bacteria, fungus, virus, toxins and parasites, the increase of drug resistant strain and multidrug resistant strain, the increase of chemical resistance and drug tolerance of pathogenic bacteria. The product in the invention contains 15-100% (by weight) of digallic acid antimicrobial active protein. The preparing method of the invention: adopting digallic acid to load antimicrobial active protein. The total efficiency of the agent can reach 100%, the diarrhea symptoms of patients can be substantially released after 1 day of taken the medicine, after 2-3 days, the cure rate can reach 85% or more. The yield of the antimicrobial active protein in the invention is 80% or higher by weight.

This invention pertains to a crystalline compound of Formula (A) as described herein and compositions containing this crystalline compound, as well as methods of using the compound or pharmaceutical compositions comprising it to treat bacterial infections. The compound and compositions are especially useful to treat Gram negative bacterial infections, including multi-drug resistant strains.

The invention provides a self-assembled dendritic antibacterial peptide Pal3RP and a preparation method thereof as well as self-assembled nano-particles and application of the self-assembled dendritic antibacterial peptide Pal3RP. The sequence of the gene is Pal-GGGK (RPRPRP) K (RPRPRP) RPRPRP, and Pal is n-hexadecanoic acid. The structural particularity of lysine as branched amino acid is utilized, and meanwhile, a cationic anti-enzymolysis unit and hexadecanoic acid are utilized to form a dendritic structure and steric hindrance between peptide chains, so that the antibacterial peptide has high antibacterial activity, low toxicity and high stability. Further, the dendritic antibacterial peptide is self-assembled into the self-assembled antibacterial peptide nano-particles with the micro-nano size through an ultrasonic standing method. The self-assembled dendritic antibacterial peptide Pal3RP nanoparticles have an obvious inhibition effect on gram negative bacteria and gram positive bacteria, have an efficient inhibition effect on multiple drug-resistant bacteria, and have very low hemolytic toxicity at the same time; the degradation degree of high-concentration protease on the dendritic antibacterial peptide Pal3RP nanoparticles is very weak.

An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. A compound represented by General Formula [1] (the reference signs in Formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant Gram-negative bacteria including multidrug-resistant Pseudomonas aeruginosa, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent.

The invention discloses a compound YT-011 resisting multi-drug resistant bacteria and a preparation method thereof. The compound YT-011 has an important supporting effect on the discovery of drugs resisting drug resistant bacteria based on a pathogenic mechanism. A technology for preparing an antibacterial active substance having a novel structure through a structure-modified microorganism-derived active mother nucleus is used as a key technology. The compound YT-011 provides a feasible method for the discovery of the innovative drug. The microorganism-derived physiological active substance having structural diversity increases the discovery ways of innovative drugs, and enriches the research and development ideas.

The present invention relates to antimicrobial peptides derived from Romo1 protein, and specifically, provides various peptides having the amino acid sequence of the α-helix 2 region of the Romo1 protein and an antibacterial composition containing each of the peptides, as a result of confirming that the peptides have antibacterial activity against gram-positive, gram-negative and multidrug-resistant bacteria. The Romo1-derived peptides and variants thereof have better bactericidal capability against various types of bacteria and multidrug-resistant bacteria than existing antibiotics and antibiotic peptides, and have antibacterial activity against various bacteria in blood vessels, and may be provided as substances for the prevention or treatment of a wide range of bacterial infectious diseases. Thus, a composition containing the antimicrobial peptide of the present invention is expected to be used in various applications, including drugs, quasi-drugs, food and feed additives, pesticide and cosmetic additives, to prevent or treat infectious diseases.

The invention relates to a Cape jasmine extractive from active components of Qingkailing, which has inbibitional effects on Acinetobacter calcoaceticus, Acinetobacter baumannii, A.baumannii, Stenotrophomonasmaltophilia and Escherichia coli containing NDM-1 drug resistant genes, therefore, the Cape jasmine extractive can be used for inhibiting the bacterial diseases and curing and / or preventing diseases caused by bacteria.

The invention relates to a small peptide resisting MDR (multiple resistant bacteria). The small peptide is characterized in that the small peptide has the function of resisting clinically isolated MDR. In-vitro activity assay results prove that 11 small peptides have different antibacterial activities for multiple MDR and have the MIC value ranging from 4 mu g / L to 128 mu g / L according to different bacteria. Compared with a mother pattern, the small peptide has enhanced pseudomonas aeruginosa and candida albicans resistant activity. 6 peptides with better antibacterial activity are selected for an in vivo experiment, results prove that the 6 peptides can notably reduce the death rate of a model mouse because of a pseudomonas aeruginosa standard strain and clinical pan-drug-resistant pseudomonas aeruginosa septicemia and have a synergistic effect with polymyxin; no hemolytic reaction is caused when the concentration of 6 small peptides is 10 mg / ml, and the product safety is higher; local stimulation experiment results of rabbit eye conjunctiva show that the small peptide has no acute toxic stimulus reaction.

The present invention relates to antimicrobial peptides derived from Romo1 protein, and provides various peptides having the amino acid sequence of the α-helix 2 region of the Romo1 protein and an antibacterial composition containing each of the peptides, as a result of confirming that the peptides have antibacterial activity against gram-positive, gram-negative and multidrug-resistant bacteria. The Romo1-derived peptides and variants thereof have better bactericidal capability against various types of bacteria and multidrug-resistant bacteria than existing antibiotics and antibiotic peptides, and have antibacterial activity against various bacteria in blood vessels, and are novel antibiotics that may be provided as substances for the prevention or treatment of a wide range of bacterial infectious diseases. A composition containing the antimicrobial peptide of the present invention is suitable for various applications, including drugs, quasi-drugs, food and feed additives, pesticides and cosmetic additives, to prevent or treat infectious diseases.