6858results about "Bandages" patented technology

The invention belongs to the field of biological materials, and particularly relates to recombinant V-type humanized collagen and application thereof. The invention provides a recombinant V-type humanized collagen, the amino acid sequence of the recombinant V-type humanized collagen comprises (repetitive unit) n, and the repetitive unit comprises a sequence as shown in SEQ ID NO.1; each repeating unit is directly linked and the number n of repeating units is 10. The recombinant V-type humanized collagen can comprehensively resist skin aging.

The invention relates to the technical field of biology, and particularly discloses a recombinant collagen III and application thereof in preparation of gel. The recombinant collagen III is designed by optimizing functional area sequences of human I-type and III-type collagen, the amino acid sequence is shown as SEQ ID No.2, and the recombinant collagen III has the characteristics of high stability, good hydrophilicity and low immunogenicity. The preparation method comprises the steps of expression vector construction, escherichia coli induced expression, affinity chromatography purification and renaturation. The recombinant collagen III can be prepared into a gel dressing and comprises sodium alginate, methylparaben and other components. Experiments show that the gel can effectively promote cell proliferation and has no cytotoxicity; in a mouse skin injury model, the collagen can relieve inflammation, accelerate wound healing and inhibit scar formation, and the effect of the collagen is superior to that of natural human III-type collagen. The invention provides a safe and efficient novel material for wound repair, and is suitable for medical dressings and tissue engineering.

The invention discloses hydrogel loaded with antibacterial polypeptide as well as a preparation method and application of the hydrogel. The preparation method of the hydrogel comprises the steps that antibacterial polypeptide and polyethylene glycol dimethacrylate are subjected to a cross-linking reaction, the hydrogel can be obtained, and the antibacterial polypeptide is obtained through polymerization synthesis of a cationic CBL monomer compound and an HBL monomer compound; the hydrogel has remarkable sterilization and anti-biofilm effects, and in-vitro cytotoxicity shows that the antibacterial polypeptide hydrogel product has no inhibition effect on normal cell growth; when the hydrogel dressing is used as a hydrogel dressing and is combined with novobiocin for use, more than 99% of antibacterial effect is achieved in a diabetes wound infection model and a fungal psoriasis infection model; and when being used as a hydrogel preparation to be combined with fluconazole, the compound has the effect of inhibiting growth of more than 99% of fungi in an animal vaginitis model.

The present disclosure relates to absorbent articles including elastic laminates and to methods and apparatuses for making absorbent articles having elastic laminates in front and / or back waist regions with frangible pathways.

The present disclosure relates to diaper pants having a first belt and a second belt with one or more frangible pathways. A frangible pathway may extend between inner edge and outer edges of a belt. A grip region comprising an accessibility opening may be positioned between the inner and outer edges of the belt. The frangible pathway may comprise a first tear zone and a second tear zone extending from the accessibility opening to a distal terminus and to a proximal terminus. Such frangible pathway configurations provide a feature that allows a belt of a diaper pant to be relatively easily torn along the frangible pathway. Once torn along the frangible pathway, the diaper pant may be removed from a wearer and rolled up for disposal. A fastener component may be connected with another portion of the diaper pant to help maintain the diaper pant in a disposal configuration.

The invention relates to a preparation method of antibacterial gamma-polyglutamic acid superabsorbent hydrogel. The preparation method comprises the following steps: (1) preparing a gamma-polyglutamic acid solution; (2) dissolving an antibacterial agent in the gamma-polyglutamic acid solution, and fully stirring and uniformly mixing to obtain a mixed solution 1; adjusting the pH value of the mixed solution 1, heating the mixed solution 1 to 60 DEG C, and continuously reacting for 1-2 hours to obtain a mixed solution 2; cooling the mixed solution 2 to room temperature, adding a cross-linking agent, and uniformly mixing to obtain a mixed solution 3; standing the mixed solution 3 at room temperature for 1-3 hours and then carrying out gradient heating reaction to obtain an antibacterial gelatinous product; and (3) dehydrating the antibacterial gelatinous product, and carrying out vacuum negative pressure drying to obtain a dried hydrogel product, namely the antibacterial gamma-polyglutamic acid super absorbent hydrogel. The antibacterial gamma-polyglutamic acid superabsorbent hydrogel prepared by the invention has good biocompatibility, is safe and non-toxic, also has excellent water absorption performance and antibacterial performance, and has a good application prospect.

The invention discloses a hydrogel patch for gastric perforation repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving acryloyl valine, acrylic acid, methylene bisacrylamide, a compound A and a photoinitiator in an alcohol solvent, and defoaming to obtain a precursor solution; and placing the precursor solution in a mold, carrying out ultraviolet-induced curing, soaking the obtained hydrogel in a hydrochloric acid solution, and replacing the alcohol solvent to obtain the hydrogel patch for gastric perforation repair. The hydrogel patch provided by the invention has the advantages of strong acid corrosion resistance, good biocompatibility, low swelling ratio, stable adhesion performance in a fluctuating pH environment and the like. The tough and stable adhesion performance ensures that the hydrogel can be permanently and reliably adhered to a gastric perforation part in a dynamic gastric acid environment, and a stable platform is provided for drug delivery, so that the surgical operation time is expected to be shortened, and wound healing is promoted.

The present disclosure relates to absorbent articles including elastic laminates, and more particularly, to methods and apparatuses for making absorbent articles having elastic laminates in front and / or back waist regions with frangible pathways.

Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.

The invention relates to the technical field of bioengineering, in particular to a recombinant VII type collagen for inhibiting scars as well as a preparation method and application of the recombinant VII type collagen. The amino acid sequence of the recombinant VII type collagen is as shown in SEQ ID NO. 1. The recombinant VII type collagen provided by the invention has a better cell adhesion function, so that the recombinant VII type collagen can be applied to the fields of preparation of tissue materials, wound dressings and the like. Meanwhile, the VII type collagen does not contain any tag or exogenous amino acid sequence, is a completely humanized sequence, and does not generate immune response. The VII type collagen has a good adhesion effect, the adhesion effect is better than that of other recombinant collagen, the adhesion effect is equivalent to that of a common cell adhesive in the market, scars can be reduced by inhibiting activation of a TGF-beta pathway, and the VII type collagen can be developed into skin care products and medical instruments for promoting traceless wound repair and has a wide application prospect.

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

The invention belongs to the technical field of hydrogel materials, and particularly relates to a Janus hydrogel patch as well as a preparation method and application thereof. The Janus hydrogel patch provided by the invention comprises an anti-adhesion layer and an adhesion layer which are laminated, the anti-adhesion layer is formed by anti-adhesion layer photosensitive ink through photocuring printing, and the anti-adhesion layer photosensitive ink comprises a first hydrogel material monomer, a hydrophilic high-molecular polymer containing a lubricating group, a first photoinitiator, a first photopolymerization inhibitor and first water; the adhesion layer is formed by photo-curing printing of adhesion layer photosensitive ink, and the adhesion layer photosensitive ink comprises a second hydrogel material monomer, a hydrophilic high-molecular polymer containing an adhesion group, a second photoinitiator, a second photopolymerization inhibitor and second water. The Janus hydrogel patch provided by the invention can realize stable adhesion and healing functions of wounds, and can effectively inhibit the postoperative adhesion problem.

The invention belongs to the technical field of dressing preparation, and particularly relates to a preparation method of a photocuring methacrylated gelatin hydrogel dressing, which comprises the following steps: step 1, dissolving methacrylated gelatin in a phosphate buffer solution to prepare a methacrylated gelatin solution with the mass concentration of 5-15%; 2, adding a natural photoinitiator into the solution obtained in the step 1, and uniformly stirring and mixing; 3, adding the traditional Chinese medicine active ingredient powder, and stirring until the powder is uniformly dispersed to obtain a mixed solution; and 4, pouring the mixed solution into a mold, and curing and molding under the irradiation of visible light. Chlorophyll or riboflavin is used as a natural photoinitiator and is directly dispersed in a methacrylated gelatin solution in a physical blending mode, a curing light source enables chlorophyll to completely avoid a chemical initiator, meanwhile, the process is simplified into physical stirring to replace nanoparticle synthesis and modification, visible light reduces the risk of tissue burn, the production cost is reduced, and the method is suitable for industrial production. The method is suitable for primary medicine.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention discloses a high-activity injectable self-healing temperature-sensitive hydrogel dressing and a preparation method and application thereof, the high-activity injectable self-healing temperature-sensitive hydrogel dressing is obtained by forming a temperature-sensitive hydrogel through a two-dimensional nano material MXene aqueous solution and F127 under the hydrogen-bond interaction, combining an M2 macrophage source exosome on MXene under the electrostatic adsorption action, and wrapping the MXene through a network structure of the hydrogel. The preparation method is simple, an obtained sample is free of organic solution residues, reaction conditions are mild, operation is convenient, the raw material cost is low, the hydrogel dressing has temperature-sensitive, injectable and self-healing performance, the hydrogel dressing has temperature-sensitive and injectable performance, is sol at normal temperature, forms gel after making contact with skin and is convenient to smear and use on wounds, and experimental results prove that the hydrogel dressing has good application prospects. The hydrogel has good biocompatibility and relatively strong antibacterial performance, and can effectively play anti-inflammatory and vascular regeneration promoting roles in diabetic wounds and promote rapid repair of the diabetic wounds.

The invention belongs to the technical field of medical products, and provides a hydrogel dressing for diabetic chronic wounds and a preparation method and application of the hydrogel dressing. The antibacterial effect of the hydrogel dressing for the chronic wound surface of diabetes mellitus is improved by increasing the ZIF-8 coated AgNPs; in the hydrogel matrix part, the pH response is dominated by adjusting the component proportion of the temperature-sensitive agent N-isopropylacrylamide and the pH response 1-vinyl imidazole; the N-isopropylacrylamide assists the extension of a macromolecular chain segment in the composite hydrogel dressing, so that the dressing can fully absorb wound exudate and is easy to peel off, and secondary damage can be avoided.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The present disclosure relates to absorbent articles having a first belt and a second belt with one or more frangible pathways. A frangible pathway may extend between a proximal terminus on an inner edge of a belt and a distal terminus on an outer edge of the belt. A grip region comprising an accessibility opening may be positioned between the inner and outer edges of the belt. The frangible pathway may comprise a first tear zone and a second tear zone extending from the accessibility opening to the distal terminus and to the proximal terminus. Such frangible pathway configurations provide a feature that allows a belt of a diaper pant to be relatively easily torn along the frangible pathway when removing the diaper pant from a wearer. The frangible pathway may be configured to allow a caregiver to initiate and / or completely tear the first belt with one hand.

A method of creating projections in a substrate is presented. A first device is provided with an outer surface defining recesses, where each recess has a first portion proximate the outer surface with a first perimeter and first depth and a second portion distal the outer surface with a second perimeter and second depth. The first perimeter is larger than the second perimeter and the first depth is less than the second depth. The first portion of the recesses substantially surrounds the second portion of the recesses. The method also includes forming a nip between a source of vibration energy and the outer surface and conveying the substrate through the nip to create precursor projections. The method also includes heating portions of the precursor projections and applying pressure to the heated portions to flatten the portions and increase a perimeter of the portions to form the projections.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The invention provides a preparation method of a shape-adaptive hydrogel material for tissue repair. The method comprises the following steps: S1, preparing HPC (Hydroxypropyl Chitosan); s2, preparation of phenylboronic acid functional chitosan PHPC (Polyhydroxyalkanoate); s3, preparing a PHPC solution; s4, preparing a polyvinyl alcohol (PVA) solution; and S5, preparing the dynamic covalent bond hydrogel. According to the invention, a dynamic covalent bond-boric acid ester bond with stimulation response capability is introduced on the basis of common dual-network CS-PVA hydrogel; on the premise of not changing the biocompatibility and biodegradability of the original dual-network hydrogel, the hydrogel is endowed with response capability under physical and chemical stimulation, and the diversity of application scenes is expanded; the dynamic mechanical behavior changes of the PCA hydrogel at four different strain rates of 0.05 mm / s, 0.5 mm / s, 5 mm / s and 50 mm / s are explored, and the passive shape adaptability of the PCA hydrogel along with tissue growth is studied; meanwhile, changes of hydrogel creep deformation and stress relaxation caused by addition of dynamic covalent bonds are researched.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

The invention relates to antibacterial hydrogel, in particular to injectable hydrogel which is antioxidant, responds to hydrogen peroxide and glucose and is antibacterial, a preparation method of the injectable hydrogel and application of the injectable hydrogel to preparation of antibacterial hydrogel dressing for repairing diabetic infectious wounds. The injectable hydrogel capable of resisting oxidation, responding to hydrogen peroxide and glucose and resisting bacteria has a porous three-dimensional network structure and mainly comprises gelatin modified by 4-carboxyphenylboronic acid, tannic acid, zinc chloride and water. The porous three-dimensional network structure is obtained by chemical crosslinking of gelatin modified by 4-carboxyphenylboronic acid and tannic acid, and zinc chloride is loaded in the hydrogel by complexing with the tannic acid. The hydrogel disclosed by the invention has good self-healing ability, injectable ability, oxidation resistance, hydrogen peroxide and glucose response property, good biocompatibility and excellent antibacterial property.

The present invention relates to the technical field of protein engineering and provides a recombinant humanized type III collagen having a triple helix structure, a preparation method therefor, and a use thereof. The amino acid sequence of the recombinant humanized type III collagen comprises n core units, wherein n is 1 or an integer greater than 1, and the amino acid sequence of the core unit is as shown in SEQ ID NO: 1. The present invention further provides a method for constructing an expression system and a method for preparing a recombinant humanized type III collagen. The present invention further provides an actual industrial use on the basis of the characteristics of the protein. The recombinant humanized type III collagen provided by the present invention has high purity, good stability, and high biological activity. Experiments have shown that the recombinant humanized type III collagen has various biological activities such as promoting cell proliferation and migration.

The invention discloses starch-collagen composite hydrogel as well as a preparation method and application thereof. Collagen is catalyzed by microbial transglutaminase to form a covalent cross-linked network, and meanwhile, hydroxypropyl starch is introduced to construct a physical interpenetrating network through molecular chain penetration and hydrogen-bond interaction; and chondroitin sulfate is further integrated to strengthen the network structure and biological activity through electrostatic interaction. The method is mild in condition and does not need a toxic chemical cross-linking agent, the obtained composite hydrogel has an interpenetrating double-network structure and has excellent mechanical properties, enzymatic degradation resistance and cell affinity, the compression modulus of the composite hydrogel is remarkably improved, the composite hydrogel can keep structural stability for a long time in a collagenase environment, cell adhesion and proliferation can be effectively promoted, and the composite hydrogel has a good application prospect. The hydrogel can be widely applied to tissue engineering scaffolds, wound dressings, drug sustained-release carriers and cartilage repair materials.

The invention discloses an antibacterial dressing for skin repair and a preparation method thereof, and relates to the field of medical dressings. The antibacterial dressing for skin repair is prepared from the following raw materials in parts by weight: 4-8 parts of carboxymethyl chitosan, 2-5 parts of collagen, 5-10 parts of glycerol, 10-20 parts of a framework material, 1-2 parts of an antibacterial agent, 1-3 parts of a humectant and 70 parts of purified water. The prepared antibacterial dressing for skin repair has good moisturizing performance and antibacterial performance.

Systems and methods for delivering a gas, such as nitric oxide, are provided. In some embodiments, systems and methods are provided for delivering a gas, such as nitric oxide, in the form of nanobubbles and / or a dissolved gas using a liquid medium.