8370results about "Bandages" patented technology

The invention discloses an antibacterial peptide and application thereof, and belongs to the technical field of biology. The antibacterial peptide with an inhibition effect on various clinically common pathogenic microorganisms is obtained, and the antibacterial peptide comprises gram-negative bacteria such as escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii, vibrio parahaemolyticus, salmonella gallinarum, salmonella typhimurium and enterobacter sakazakii, and gram-positive bacteria. The antibacterial peptide provided by the invention can be used as an antibacterial peptide, such as staphylococcus aureus, listeria monocytogenes and bacillus cereus, and the antibacterial peptide provided by the invention is novel in structure and easy to prepare.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention belongs to the field of biological materials, and particularly relates to recombinant V-type humanized collagen and application thereof. The invention provides a recombinant V-type humanized collagen, the amino acid sequence of the recombinant V-type humanized collagen comprises (repetitive unit) n, and the repetitive unit comprises a sequence as shown in SEQ ID NO.1; each repeating unit is directly linked and the number n of repeating units is 10. The recombinant V-type humanized collagen can comprehensively resist skin aging.

The invention relates to the technical field of biology, and particularly discloses a recombinant collagen III and application thereof in preparation of gel. The recombinant collagen III is designed by optimizing functional area sequences of human I-type and III-type collagen, the amino acid sequence is shown as SEQ ID No.2, and the recombinant collagen III has the characteristics of high stability, good hydrophilicity and low immunogenicity. The preparation method comprises the steps of expression vector construction, escherichia coli induced expression, affinity chromatography purification and renaturation. The recombinant collagen III can be prepared into a gel dressing and comprises sodium alginate, methylparaben and other components. Experiments show that the gel can effectively promote cell proliferation and has no cytotoxicity; in a mouse skin injury model, the collagen can relieve inflammation, accelerate wound healing and inhibit scar formation, and the effect of the collagen is superior to that of natural human III-type collagen. The invention provides a safe and efficient novel material for wound repair, and is suitable for medical dressings and tissue engineering.

The invention discloses hydrogel loaded with antibacterial polypeptide as well as a preparation method and application of the hydrogel. The preparation method of the hydrogel comprises the steps that antibacterial polypeptide and polyethylene glycol dimethacrylate are subjected to a cross-linking reaction, the hydrogel can be obtained, and the antibacterial polypeptide is obtained through polymerization synthesis of a cationic CBL monomer compound and an HBL monomer compound; the hydrogel has remarkable sterilization and anti-biofilm effects, and in-vitro cytotoxicity shows that the antibacterial polypeptide hydrogel product has no inhibition effect on normal cell growth; when the hydrogel dressing is used as a hydrogel dressing and is combined with novobiocin for use, more than 99% of antibacterial effect is achieved in a diabetes wound infection model and a fungal psoriasis infection model; and when being used as a hydrogel preparation to be combined with fluconazole, the compound has the effect of inhibiting growth of more than 99% of fungi in an animal vaginitis model.

The present disclosure relates to absorbent articles including elastic laminates and to methods and apparatuses for making absorbent articles having elastic laminates in front and / or back waist regions with frangible pathways.

The present disclosure relates to diaper pants having a first belt and a second belt with one or more frangible pathways. A frangible pathway may extend between inner edge and outer edges of a belt. A grip region comprising an accessibility opening may be positioned between the inner and outer edges of the belt. The frangible pathway may comprise a first tear zone and a second tear zone extending from the accessibility opening to a distal terminus and to a proximal terminus. Such frangible pathway configurations provide a feature that allows a belt of a diaper pant to be relatively easily torn along the frangible pathway. Once torn along the frangible pathway, the diaper pant may be removed from a wearer and rolled up for disposal. A fastener component may be connected with another portion of the diaper pant to help maintain the diaper pant in a disposal configuration.

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The invention relates to a preparation method of antibacterial gamma-polyglutamic acid superabsorbent hydrogel. The preparation method comprises the following steps: (1) preparing a gamma-polyglutamic acid solution; (2) dissolving an antibacterial agent in the gamma-polyglutamic acid solution, and fully stirring and uniformly mixing to obtain a mixed solution 1; adjusting the pH value of the mixed solution 1, heating the mixed solution 1 to 60 DEG C, and continuously reacting for 1-2 hours to obtain a mixed solution 2; cooling the mixed solution 2 to room temperature, adding a cross-linking agent, and uniformly mixing to obtain a mixed solution 3; standing the mixed solution 3 at room temperature for 1-3 hours and then carrying out gradient heating reaction to obtain an antibacterial gelatinous product; and (3) dehydrating the antibacterial gelatinous product, and carrying out vacuum negative pressure drying to obtain a dried hydrogel product, namely the antibacterial gamma-polyglutamic acid super absorbent hydrogel. The antibacterial gamma-polyglutamic acid superabsorbent hydrogel prepared by the invention has good biocompatibility, is safe and non-toxic, also has excellent water absorption performance and antibacterial performance, and has a good application prospect.

The invention provides a recombinant humanized elastin with high biological activity as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering and biological materials. 100% of the amino acid sequence of the elastin is derived from human elastin and is prepared by expression of genetically engineered bacteria; the protein has a typical beta-spiral hydrophobic structural domain and a lysine-rich hydrophilic structural domain, has a good bionic structure and functional characteristics, can significantly promote proliferation, adhesion and migration of human skin fibroblasts, also has excellent antioxidant, anti-wrinkle and anti-aging activities, and can be used for preparing a biomimetic protein. The hydrogel can be widely applied to the fields of skin repair dressings, injection implants, artificial skin, biomedical materials, functional skin care products and the like; in addition, the elastin is good in solubility, high in stability, mature in expression system and suitable for large-scale production.

The invention discloses a hydrogel patch for gastric perforation repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving acryloyl valine, acrylic acid, methylene bisacrylamide, a compound A and a photoinitiator in an alcohol solvent, and defoaming to obtain a precursor solution; and placing the precursor solution in a mold, carrying out ultraviolet-induced curing, soaking the obtained hydrogel in a hydrochloric acid solution, and replacing the alcohol solvent to obtain the hydrogel patch for gastric perforation repair. The hydrogel patch provided by the invention has the advantages of strong acid corrosion resistance, good biocompatibility, low swelling ratio, stable adhesion performance in a fluctuating pH environment and the like. The tough and stable adhesion performance ensures that the hydrogel can be permanently and reliably adhered to a gastric perforation part in a dynamic gastric acid environment, and a stable platform is provided for drug delivery, so that the surgical operation time is expected to be shortened, and wound healing is promoted.

The present disclosure relates to absorbent articles including elastic laminates, and more particularly, to methods and apparatuses for making absorbent articles having elastic laminates in front and / or back waist regions with frangible pathways.

Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.

The invention discloses a photo-thermal composite hydrogel patch and a preparation method and application thereof.The hydrogel patch is of a three-dimensional latticed porous structure formed by taking methylacryloyl gelatin (GelMA) and methylacryloyl hyaluronic acid (HAMA) as matrixes, loading niobium carbide nano-particles (Nb2CNPs) and vinipofen (VP) and conducting 3D printing or casting molding, the hydrogel patch is named as VP-Nb2C-coated GelMA / HAMA (VNGH) hydrogel patch for short. The VNGH has good photo-thermal antibacterial property, oxidation resistance and reepithelization promoting function, can significantly improve the quality of mouse diabetic wound healing, and provides a new thought and strategy for realizing scar-free healing of diabetic wounds.

Disclosed herein are embodiments of a wound treatment apparatus with electronic components integrated within a wound dressing. In some embodiments, a wound dressing apparatus can comprise a wound dressing. The wound dressing can comprise an absorbent material, an electronics unit comprising a negative pressure source, the electronics unit integrated within the wound dressing and at least partially encapsulated by a flexible film. The flexible film can comprise a window or aperture configured to permit fluid communication between the absorbent material and the negative pressure source. In some embodiments, a wound dressing apparatus can comprise a wound contact layer, an absorbent layer over the wound contact layer, the absorbent layer comprising one or more apertures, a cover layer configured to cover and form a seal over the wound contact layer and the absorbent layer, and an electronics assembly comprising a negative pressure source. A portion of the cover layer overlying the one or more apertures in the absorbent layer can be configured to be compressed within the aperture in the absorbent layer when negative pressure is applied to the wound dressing apparatus. The compressed cover layer can indicate a level of negative pressure below the cover layer. In some embodiments, the wound dressing apparatus can comprise an indicator material layer and a cover layer configured to cover and form a seal over the wound contact layer and the indicator material layer. The indicator material layer can be configured to protrude relative to a surrounding surface of an upper surface of the wound dressing apparatus when negative pressure is applied to the wound dressing apparatus and the protruding indicator material layer indicates a level of negative pressure below the cover layer.

The invention relates to the technical field of bioengineering, in particular to a recombinant VII type collagen for inhibiting scars as well as a preparation method and application of the recombinant VII type collagen. The amino acid sequence of the recombinant VII type collagen is as shown in SEQ ID NO. 1. The recombinant VII type collagen provided by the invention has a better cell adhesion function, so that the recombinant VII type collagen can be applied to the fields of preparation of tissue materials, wound dressings and the like. Meanwhile, the VII type collagen does not contain any tag or exogenous amino acid sequence, is a completely humanized sequence, and does not generate immune response. The VII type collagen has a good adhesion effect, the adhesion effect is better than that of other recombinant collagen, the adhesion effect is equivalent to that of a common cell adhesive in the market, scars can be reduced by inhibiting activation of a TGF-beta pathway, and the VII type collagen can be developed into skin care products and medical instruments for promoting traceless wound repair and has a wide application prospect.

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The present invention relates to the field of biomedical materials, particularly to a novel composite collagen material for wound repair, and more specifically to a method for preparing a novel composite collagen material comprising recombinant humanized collagen type 21 (ColpepA1 21) and its use in wound repair. The present invention utilizes ColpepA1 21 to significantly promote key biological reactions in the wound healing process, including accelerating cell migration, enhancing skin hydration and barrier function, and improving the stability and elasticity of skin structure. The resulting novel composite collagen material effectively promotes wound healing and cell regeneration, alleviating oxidative damage.

The invention provides a soybean amyloid protein fiber, a preparation method thereof, a high internal phase emulsion and application, and belongs to the technical field of protein fibers. The preparation method comprises the following steps: dissolving soybean protein isolate in water, adjusting the obtained soybean protein isolate solution to a first pH value, carrying out ultrasonic treatment and / or first stirring treatment, adjusting the obtained feed liquid to a second pH value, sequentially carrying out second stirring treatment, dialysis and freeze drying, and dissolving the obtained pretreated soybean protein isolate in water, adjusting the pH value of the pretreated soybean protein isolate solution to a third pH value, and sequentially performing hydration treatment and fiber growth treatment to obtain the soybean amyloid protein fiber. The invention provides a soybean amyloid protein fiber preparation method based on ultrasonic pretreatment and / or pH migration pretreatment. The yield and the emulsifying property of the obtained soybean amyloid protein fiber can be remarkably improved.

The present invention provides a phycocyanin-collagen composite hydrogel and its preparation method and application. The present invention utilizes transglutaminase to catalyze the combination of phycocyanin and collagen to form a new, more stable collagen; transglutaminase acts between protein molecules, utilizes lysine and glutamic acid in phycocyanin and collagen to transfer acyl groups, and cross-links to form new chemical bonds, thereby enhancing the binding strength of phycocyanin and collagen; the hydrogel prepared by the present invention can be used to prepare medical materials and combined with skin injury sites to solve the problem that traditional dressings are easy to adhere to wounds and easily penetrated by tissue fluid and become infected. In addition to ensuring basic air permeability, it reduces the adhesion of the dressing, increases moisture retention and antioxidant properties, and avoids secondary damage when replacing a new dressing. The hydrogel prepared by the present invention has a certain antioxidant capacity and can be used to prepare products with antioxidant effects.

The invention is directed to a hemostasis therapeutic compression system including an apparatus and system to stop bleeding and assist recovery at a wound location. The hemostasis therapeutic compression apparatus includes a bladder having a transparent portion to visualize the bleeding wound location as well as having one side with an interface pressure sufficient to stop bleeding at the wound site, and the wrap has as an elongated tab as part of a hook and loop portion for self-application by the user or patient. The hemostasis therapeutic compression apparatus includes compression not just on the bleeding wound site but alongside the site for increased and faster recovery and less complications. The transparent portion of the bladder may be in the shape of a circle, oval, kidney, elongated kidney, square, rectangle, "U", "C", and other known shapes depending on the size and location of the bleeding wound site on the limb.

Disclosed herein is a pressurized therapeutic composition configured to be stored in a valved container designed to maintain an inverse thermosensitive polymer foam composition under pressure and dispense the composition upon opening the valve thereof. After the composition is dispensed from the container the evaporation of an expanding component (e.g., compressed gas or volatile liquid) can cause the inverse thermosensitive polymer solution to foam. The reduced pressure produced from dispensing the inverse thermosensitive polymer solution can reduce its temperature so as to facilitate distribution in a more liquid foam form. The inverse thermosensitive polymer solution can undergo a reverse phase change from a liquid to a gel upon warming (e.g., once dispensed onto or into a body part).

The device comprises a pre-stretching elastic film layer which is sequentially stacked, a gradient drainage layer is arranged below the pre-stretching elastic film layer, and sealing edges are arranged on the outer edges of the pre-stretching elastic film layer and the gradient drainage layer. The sealing edge surrounds the edges of the pre-stretching elastic film layer and the gradient drainage layer and is used for being bonded with the skin to form a closed cavity. Continuous negative pressure is provided through retraction force of the pre-stretched elastic thin film layer, compared with a traditional external pump, the cost is lower, use is more convenient, adhesion with a postoperative wound part is prevented through the arrangement of the anti-adhesion contact layer, and the postoperative wound part is prevented from being damaged. And meanwhile, the anti-adhesion contact layer is provided with a micron-sized bulge array and nano-sized surface textures, so that the anti-adhesion effect is further ensured, and the drainage efficiency is improved through the design of the gradient drainage layer.

The invention belongs to the technical field of hydrogel materials, and particularly relates to a Janus hydrogel patch as well as a preparation method and application thereof. The Janus hydrogel patch provided by the invention comprises an anti-adhesion layer and an adhesion layer which are laminated, the anti-adhesion layer is formed by anti-adhesion layer photosensitive ink through photocuring printing, and the anti-adhesion layer photosensitive ink comprises a first hydrogel material monomer, a hydrophilic high-molecular polymer containing a lubricating group, a first photoinitiator, a first photopolymerization inhibitor and first water; the adhesion layer is formed by photo-curing printing of adhesion layer photosensitive ink, and the adhesion layer photosensitive ink comprises a second hydrogel material monomer, a hydrophilic high-molecular polymer containing an adhesion group, a second photoinitiator, a second photopolymerization inhibitor and second water. The Janus hydrogel patch provided by the invention can realize stable adhesion and healing functions of wounds, and can effectively inhibit the postoperative adhesion problem.

The invention belongs to the technical field of dressing preparation, and particularly relates to a preparation method of a photocuring methacrylated gelatin hydrogel dressing, which comprises the following steps: step 1, dissolving methacrylated gelatin in a phosphate buffer solution to prepare a methacrylated gelatin solution with the mass concentration of 5-15%; 2, adding a natural photoinitiator into the solution obtained in the step 1, and uniformly stirring and mixing; 3, adding the traditional Chinese medicine active ingredient powder, and stirring until the powder is uniformly dispersed to obtain a mixed solution; and 4, pouring the mixed solution into a mold, and curing and molding under the irradiation of visible light. Chlorophyll or riboflavin is used as a natural photoinitiator and is directly dispersed in a methacrylated gelatin solution in a physical blending mode, a curing light source enables chlorophyll to completely avoid a chemical initiator, meanwhile, the process is simplified into physical stirring to replace nanoparticle synthesis and modification, visible light reduces the risk of tissue burn, the production cost is reduced, and the method is suitable for industrial production. The method is suitable for primary medicine.

The invention relates to the technical field of biological materials, in particular to silver nano-chlorogenic acid composite hydrogel as well as preparation and application thereof. According to the invention, the CGA and the silver nitrate are used for green synthesis of the nano-particles CGA-AgNPs, and the nano-particles have peroxide nano-enzyme activity and antibacterial activity; and the CGA-AgNPs and chitosan (CS) are cross-linked to form the silver nano-chlorogenic acid composite hydrogel CGA-AgNPs-CS, so that the uniform distribution of nano-particles in the hydrogel can be promoted. According to the invention, multi-functionalization is taken as a target, a novel hydrogel composition system is designed from the source, the provided preparation method is green, simple, rapid and environment-friendly, the obtained composite hydrogel has multiple functions, and a good foundation is laid for expansion and application of the composite hydrogel in the biomedical fields of wound repair, wearable equipment, nano antibacterial drugs and the like.