19490results about "Bandages" patented technology

Sanitary tissue products of the present disclosure may comprise at least about 70% short fibers and / or having a weight weighted mean fiber length of less than about 1.4, and may have one or a combination of premium performance parameter(s). One or more of said sanitary tissue products may form part of an array of sanitary tissue products.

The invention discloses a preparation method and application of a multifunctional self-healing hydrogel material with antibacterial, anti-inflammatory and diabetic wound healing promotion functions. The preparation method comprises the following steps: firstly, synthesizing silver-doped carbon quantum dots (AgCD) in one step through a hydrothermal method; the preparation method comprises the following steps: firstly, preparing sodium hyaluronate (HA), secondly, oxidizing the sodium hyaluronate (HA) into oxidized hyaluronic acid (OHA) by taking sodium periodate as an oxidizing agent, and then encapsulating AgCD and metformin (Met) into hydrogel formed by Schiff base reaction between carboxymethyl chitosan (CMCS) and the oxidized hyaluronic acid (OHA). The hydrogel provided by the invention has certain adhesion, suitable capacity of absorbing wound exudate and good biocompatibility, meanwhile, due to the addition of AgCD, the hydrogel has excellent antibacterial property, and the metformin can promote angiogenesis of a wound part, so that the hydrogel can better promote healing of a diabetic wound. The hydrogel is simple and rapid in preparation method, has low biotoxicity and antibacterial property, and provides a strategic choice for promoting healing of diabetic wounds.

The present invention provides an MOF / cellulose hydrogel, and a preparation method therefor and the use thereof. By defining the composition and sequence of added components, MOF is combined into the matrix of a hydrogel, and self-assembly is performed to generate a reticular nanofiber structure, thereby greatly improving the mechanical strength, the fatigue resistance, the self-repairing property and the biocompatibility of the hydrogel; the cellulose is defined, and in the case that any chemical cross-linking agent is not added, the hydrogel is reinforced and toughened by means of the combined action of modified carboxymethyl cellulose nanofibers with a polyanionic cellulose, a hydrogen bond, and the complexation of a metal and ligand carboxyl group, so as to achieve antibacterial durability; and a coordination compound of metal ions in the metal salt solution is defined, and rigid 1,2,4,5-pyromellitic acid is used as a main ligand and flexible 1,3-bis(1H-imidazol-1-ylmethyl)benzene is used as an auxiliary ligand to perform self-assembly, so as to generate a reticular hyperbranched nanofiber structure, thereby greatly improving the mechanical property and the antibacterial performance of the hydrogel.

The invention provides a recombinant humanized III-type collagen with a triple helix structure and preparation and application thereof, and belongs to the technical field of protein engineering, the amino acid sequence of the recombinant humanized III-type collagen comprises n core units, n is an integer of 1 or greater than 1, and the amino acid sequence of each core unit is as shown in SEQ ID NO: 1; the invention also provides a construction method of the expression system and a preparation method of the recombinant humanized III-type collagen. The invention also provides practical industrial application according to the characteristics of the protein. The recombinant humanized III-type collagen provided by the invention is high in purity, good in stability and high in biological activity, and experiments show that the recombinant humanized III-type collagen has various biological activities of promoting cell proliferation and migration and the like.

The invention provides temperature and pH responsive hydrogel entrapped with chlorogenic acid lipidosome as well as a preparation method and application of the temperature and pH responsive hydrogel, and relates to the technical field of biology. The temperature and pH responsive hydrogel entrapping chlorogenic acid lipidosome contains chlorogenic acid lipidosome, phenylboronic acid grafted modified gelatin and dopamine grafted oxidized hyaluronic acid, the concentration of the phenylboronic acid grafted modified gelatin is 3-10 wt%, the concentration of the dopamine grafted oxidized hyaluronic acid is 3-10 wt%, and the concentration of chlorogenic acid is 1-20 [mu] M. The temperature and pH responsive hydrogel can effectively promote wound healing independently or in combination with blue light.

Sanitary tissue products of the present disclosure may comprise at least about 70% short fibers and / or having a weight weighted mean fiber length of less than about 1.4, and may have one or a combination of premium performance parameter(s). One or more of said sanitary tissue products may form part of an array of sanitary tissue products.

Absorbent articles with front and rear opening features are disclosed. An article may comprise an insert comprising an outer cover, a liner, and a core between the outer cover and liner, a first waist panel coupled to the insert throughout a first attachment region, and a second waist panel coupled to the insert throughout a second attachment region, the second panel being coupled to the first panel proximate a first side edge of the article and the second side edge of the article and further comprising a weakened region. The second attachment may comprise a low-strength attachment zone and a high-strength attachment zone, the high-strength attachment zone disposed proximate the attachment region bottom edge. The low-strength attachment zone may further have a first peel strength and the high-strength attachment zone may have a second peel strength, the second peel strength greater than the first.

The present disclosure relates to a recombinant collagen, peptide fragments thereof, and sequence variants thereof. A novel Pichia pastoris strain for producing the recombinant collagen, fragments thereof, and sequence variants thereof, and methods of using the recombinant collagen, fragments, and sequence variants thereof are also provided. The present disclosure fulfills a need for environmentally friendly and safe alternatives for skincare.

The invention relates to the technical field of medical instruments, and provides a vacuum sealing drainage dressing and a wound surface treatment device.The vacuum sealing drainage dressing comprises a sealing layer and a dressing layer which are sequentially arranged in a stacked mode from top to bottom, and further comprises a drainage assembly; the drainage assembly comprises a sucker and a drainage tube, the sucker is arranged at the adsorption opening of the sealing layer, and the drainage tube is connected to the sucker; the dressing layer is of a porous structure, hole walls are communicated with one another to form a continuous channel, the dressing layer is provided with a flexible plasma patch, the flexible plasma patch is suitable for generating plasma acting on a wound surface, and the flexible plasma patch is provided with through holes communicated with pores. The flexible plasma patch is integrally arranged on the dressing layer, negative pressure drainage and wound sterilization and disinfection combined healing promoting treatment can be achieved, the wound or wound treatment process can be simplified, inconvenience caused by frequent dressing change is reduced, and the faster and better healing effect is achieved.

Disclosed herein are systems and methods for providing targeted temperature management (TTM) therapy to a patient. Systems included herein provide an airflow to the patient in additional to a liquid flow that define a thermal energy exchange with the patient. Various systems may provide air at a defined TTM temperature to a thermal contact pad, a mattress or a ventilator that delivers the TTM air to the patient via the ventilation therapy. Also disclosed herein are systems, devices, and methods for preventing, managing, and / or removing perspiration moisture from between the thermal contact pad and the patient. Disclosed herein is a thermal contact pad includes a wicking material to draw moisture away from the patient. Disclosed herein also is a thermal contact pad including airflow that draws moisture away from the patient.

The invention relates to the field of biomedical materials, in particular to a novel composite collagen material for wound repair, and particularly relates to a preparation method of the novel composite collagen material containing 21-type recombinant humanized collagen (ColpepA1 21) and application of the novel composite collagen material in wound repair. The ColpepA1 21 is used for remarkably promoting key biological reactions in the wound healing process, including accelerating cell migration, enhancing the skin hydration state and barrier function and improving the stability and elasticity of the skin structure, a novel composite collagen material is developed, wound healing and cell regeneration can be effectively promoted, and oxidative damage can be relieved.

The invention discloses a recombinant XII type collagen as well as a preparation method and application thereof. The amino acid sequence of the recombinant XII type collagen is any one of (A1)-(A3); (A1) is an amino acid sequence as shown in SEQ ID NO: 1; (A2) is an amino acid sequence which is obtained by substitution, deletion or insertion of one or more amino acid residues of the amino acid sequence as shown in SEQ ID NO: 1 and has the same functional protein; and (A3) is an amino acid sequence of a fusion protein obtained by connecting a protein tag to the N terminal or / and C terminal of the sequence (A1) or (A2). The recombinant XII type collagen provided by the invention has good antioxidant activity, and has a repairing effect on the problems of skin laxity, wrinkle increase and the like caused by degradation of type I collagen fibers of aged skin.

The invention relates to the field of disposable hygienic products, in particular to a high-diffusion baby paper diaper and a preparation method thereof.The prepared baby paper diaper has the advantages of being good in flow guide effect and high in absorption efficiency. The absorption core layer comprises a top layer non-woven fabric, a middle non-woven fabric, a bulky non-woven fabric, a bottom layer non-woven fabric, a wood pulp fiber layer, a first absorption material layer and a second absorption material layer, the first absorption material layer comprises first polymer water-absorbent resin particles and first wood pulp fibers, and the second absorption material layer comprises second polymer water-absorbent resin particles. The second absorbing material layer is arranged between the bulky non-woven fabric and the bottom layer non-woven fabric, part of the second macromolecule water-absorbent resin particles on the second absorbing material layer are embedded in pores of the bulky non-woven fabric, and the first absorbing material layer is arranged between the bulky non-woven fabric and the middle non-woven fabric. And a part of the first high-molecular water-absorbent resin particles on the first absorbing material layer are embedded in pores of the bulky non-woven fabric.

The invention belongs to the technical field of metal organic frameworks, and particularly relates to a high-performance photocatalytic metal organic framework antibacterial material as well as a preparation method and application thereof. The preparation method comprises the following steps of: growing a metal organic framework UiO 66 which takes a cerium element as a metal node on a single-layer graphene oxide UiO66 (at) GO in situ, loading arginine small molecules in the MOF framework to obtain a high-performance photocatalytic MOF antibacterial material UiO66 (at) GO (at) arg, forming a nano hydrogel with a stable three-dimensional structure with chitosan, and performing antibacterial treatment by using the nano hydrogel as a wound dressing. The Ce-based MOF composite QCS / GO-UiO 66-coated arg / PNIPAm hydrogel prepared by the preparation method disclosed by the invention has excellent properties such as elasticity, adhesive power, water absorption and biocompatibility; and under illumination, the photocatalyst has an excellent photocatalytic sterilization effect, and has a good killing effect on escherichia coli and staphylococcus aureus.

The embodiment of the invention discloses a preparation method of exosome-loaded hydrogel, the exosome-loaded hydrogel and application of the exosome-loaded hydrogel. A specific embodiment of the method comprises the following steps: carrying out oxidation treatment on hyaluronic acid; carrying out mixed reaction on oxidized hyaluronic acid and methacrylic anhydride under a preset environmental condition to obtain a first mixed solution; performing dialysis and freeze-drying treatment on the first mixed solution to obtain target oxidized hyaluronic acid; adding the target oxidized hyaluronic acid into the exosome solution to obtain an exosome-loaded oxidized hyaluronic acid solution; the exosome-loaded oxidized hyaluronic acid solution and polylysine are subjected to a mixed reaction, the exosome-loaded hydrogel is obtained, and the mass ratio of target oxidized hyaluronic acid to polylysine in the exosome-loaded hydrogel ranges from 1 to 2. According to the embodiment, the mechanical property and controllable degradability of the exosome-loaded hydrogel can be improved, so that the applicability of the exosome-loaded hydrogel and the retention capacity and activity of the exosome are improved.

The invention discloses multifunctional hydrogel and application thereof, and belongs to the technical field of biological medicine. According to the multifunctional hydrogel, ketal mercaptan with two hydrazide ends and oxidized dextran are cross-linked to form a cross-linked network containing dynamic covalent bonds. The preparation method comprises the following steps: dissolving ketal mercaptan with two hydrazide ends in deionized water to obtain a ketal mercaptan solution, dissolving oxidized dextran in deionized water to obtain an oxidized dextran solution, mixing the ketal mercaptan solution with the oxidized dextran solution, and standing to obtain the multifunctional hydrogel. The multifunctional hydrogel has pH / ROS dual responsiveness, can respond to inflammation microenvironment and low pH of infectious wounds, remove active oxygen, release therapeutic drugs, regulate macrophage polarization and relieve bacterial infection, thereby playing a key role in inflammation, proliferation and remodeling stages of wound healing to accelerate wound healing. The curcumin-encapsulated liposome is added into the multifunctional hydrogel, so that the antibacterial effect can be further improved.

The invention relates to the technical field of skin care, in particular to a collagen composition with anti-wrinkle and repairing effects and a preparation method. Comprising 1.5-4.5 parts of mixed collagen, 2.5-5 parts of mixed polypeptide and 4-8 parts of mixed extract, wherein the mixed extract comprises 1-2 parts of centella asiatica extract, 1-2 parts of polygonum cuspidatum root extract, 1-2 parts of bilberry fruit extract and 1-2 parts of bidens pilosa extract; the collagen is directly supplied to the skin to supplement collagen, and is mainly used for repairing the skin structure, increasing the density, elasticity and compactness of the skin and remarkably improving fine wrinkles and looseness; the polypeptide inhibits the expression of MMP-1; the natural plant active ingredients promote the expression of TGF-beta, enhance the activity of fibroblasts, accelerate the synthesis of collagen, prevent excessive oxidation of skin, repair skin inflammation, activate cell energy and delay skin aging.

The invention belongs to the technical field of bioengineering, and particularly relates to recombinant III-type humanized collagen as well as a coding gene and application thereof. According to the invention, a novel III-type humanized collagen sequence is designed by adopting an advanced AI technology and molecular dynamics simulation, so that the recombinant III-type humanized collagen product is ensured to have high stability and degradation resistance. According to the invention, the screened new III-type humanized collagen sequence is transferred to the pichia pastoris strain for recombinant expression, and the prepared recombinant III-type humanized collagen has the advantages of strong stability, high expression quantity and good hydrophilicity, and meanwhile, the recombinant III-type humanized collagen also has obvious effects of promoting cell proliferation and cell adhesion.

An absorbent article having a front edge intended to be positioned at a front side of a person and a rear edge intended to be positioned at a rear side of a person, said absorbent article comprising a liquid pervious topsheet, a liquid impervious backsheet, and an absorbent material between said topsheet and said backsheet, wherein at least a first spacer element is included between said topsheet and said backsheet, wherein the first spacer element has a top side facing the topsheet, a bottom side facing the backsheet, and a number of lateral sides between the top and the bottom side, and wherein the absorbent material extends along at least two opposite lateral sides of the first spacer element; said first spacer element being configured to guide liquid to the absorbent material upon wetting of the absorbent article.

The invention discloses a double-layer surface layer centrally-compounded urine and excrement combined absorption paper diaper and a production process thereof, and relates to the technical field of absorption products, the double-layer surface layer centrally-compounded urine and excrement combined absorption paper diaper comprises a paper diaper main body and a waistline area, the paper diaper main body comprises a surface layer, an absorption core body and a bottom layer, the absorption core body is clamped between the surface layer and the bottom layer, and the waistline area is arranged between the surface layer and the bottom layer; the waistline area comprises a front waistline area and a rear waistline area, the skin-friendly hot-air non-woven fabric surface layer of the surface layer can quickly lock urine and guide flow through the rhombic groove area, the air permeability is enhanced in combination with the salient point punching area, and the contact surface is kept dry and comfortable; the absorption core body adopts an ultrasonic edge compounding and middle hot melt adhesive combined process, so that the adhesive amount is reduced, a water absorption expansion space is reserved, and liquid permeation is accelerated; the bottom layer is compounded with the waterproof breathable film through micropore treatment, a double-micropore structure is formed, and the bottom breathability is greatly improved on the basis of blocking liquid leakage. The overall design realizes triple improvement of flow guide efficiency, air permeability and skin comfort through structural optimization.

The invention relates to self-healing double-layer hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the self-healing double-layer hydrogel, and belongs to the technical field of medical materials of surgical supplies containing macromolecular materials. The hydrogel comprises an inner layer and an outer layer, the inner layer is self-healing hydrogel in which microalgae cells are uniformly distributed, and the outer layer is self-healing hydrogel in which metal ion-humic acid coordination nanoparticle compounds are uniformly distributed, the self-healing hydrogel is formed by self-crosslinking of a macromolecular polymer containing an aldehyde group and a macromolecular polymer containing an amino group. The hydrogel provided by the invention has excellent biocompatibility, adhesion and self-healing performance, can meet the requirements of actual production and application, and has a relatively great application prospect as a dressing for chronic diabetes wounds; and the preparation process has the characteristics of simplicity in operation, low cost and mild reaction conditions, and is suitable for large-scale popularization and application.

The invention belongs to the field of biomedical materials, and provides a chiral multilevel structure antibacterial film and a preparation method and application thereof, and in the preparation process of the film, atomic-level nanosheets are assembled to form a microenvironment with a chiral multilevel structure. The adhesion behavior of bacteria can be selectively regulated and controlled through a chiral multilevel structure, and the growth of a bacterial biofilm is controlled, so that an antibacterial effect is generated. Besides, the nanosheet plays a role of a blade array and also provides a physical tool for destroying a bacterial membrane, the D-CHAPFs with the blade array structure has the effect of inhibiting the growth of the bacterial biomembrane, and the inhibition rate is 90-96%. The antibacterial film is beneficial to repair of infected wounds while resisting bacteria. Based on the above points, construction of a chiral multilevel structure microenvironment, selective regulation and control of bacterial adhesion behaviors and regulation and damage of bacterial membrane growth are realized, and an antibacterial function is realized on the whole.

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The invention relates to the field of gene engineering, and particularly discloses a barnacle chitin antibacterial peptide, an engineering algal strain of the barnacle chitin antibacterial peptide and a preparation method and application of the engineering algal strain. Wherein the amino acid sequence of the barnacle chitin antibacterial peptide is as shown in SEQ ID NO. 1; or an amino acid sequence which is obtained by substitution and / or deletion and / or addition of one or more amino acids of SEQ ID NO.1 and has the same function as SEQ ID NO.1; or an amino acid sequence which has 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% homology with the SEQ ID NO.1 and has the same function as the SEQ ID NO.1. The brand-new barnacle chitin antibacterial peptide obtained in the application has a good antibacterial effect, bacteria can be killed through a cell protection barrier, and the cell hemolysis rate at the minimum inhibition concentration is 7.2%.

The invention relates to lactobacillus crispatus LC30 for preventing and treating female genital tract infection and application of the lactobacillus crispatus LC30. The lactobacillus crispatus LC30 is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC NO.31923. The lactobacillus crispatus LC30 has good hydrogen peroxide production capacity and adhesion capacity, has a strong inhibition effect on main vaginitis pathogenic bacteria, and can be used for preventing and treating female genital tract infection. The composition is effective to nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent and treat drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cytokines and achieve the effect of relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

A nonwoven fabric comprises a first surface, a second surface, and a visually discernible pattern on at least one of the first and second surfaces. The visually discernible pattern has a regular, repeating pattern of three-dimensional features. Each of the three-dimensional features define a microzone comprising a first region and a second region. The first and second regions having a difference in values for an intensive property. The first surface has a TS7 value in the range of about 1 dB V2 rms to about 15 dB V2 rms. The second surface has a TS7 value in the range of about 1 dB V2 rms to about 15 dB V2 rms. A ratio of the TS7 value of the first surface to the TS7 value of the second surface is in the range of about 1 to about 3.

The invention belongs to the technical field of biomedical materials, and relates to ultrasonic response adhesion integrated hydrogel as well as a preparation method and application thereof, the hydrogel comprises a hydrogel matrix, an interface anchoring agent and a functional load component; the preparation method comprises the following steps: 1, preparing a hydrogel precursor solution, and preparing a hydrogel matrix into a solution; 2, carrying out mold molding or injection crosslinking on the solution prepared in the step 1 to form hydrogel; 3, preparing an interface anchoring agent solution, and dissolving or dispersing an interface anchoring agent in a solvent to prepare the interface anchoring agent solution; the ultrasonic responsive adhesive hydrogel platform provided by the invention can provide an efficient, controllable and universal solution for tissue adhesion, targeted therapy, wearable attachment and the like in a complex microenvironment, and is suitable for a plurality of clinical scenes such as chronic wound management, surgical postoperative closure, infection control, adhesive bioelectronic fixation, soft tissue engineering and the like.

A package of one or more absorbent articles is disclosed. The package includes a package material enclosing the one or more absorbent articles. The package material has natural fibers and forms a front panel, a back panel opposite the front panel, a first side panel, a second side panel opposite the first side panel, a top panel, and a bottom panel opposite the top panel. The panels define an interior compartment. The package material has a Basis Weight of between about 55 gsm and about 115 gsm, according to the Basis Weight Test Method. The package has a weakened region. The package is sealed such that the one or more absorbent articles are enclosed in the interior compartment.

An improved fecal incontinence leak prevention underwear or undergarment designed to address the challenges faced by individuals with fecal incontinence, including the risk of leaks and stains on clothing is described. The rear surface of the underwear or undergarment has a multi-layered rear surface adapted to cover a buttock region of the wearer. The multi-layered portion is strategically designed to extend from the crotch region to the cleft of a wearer. The multi-layered portion comprises an innermost layer made from moisture-resistant fabric, a middle layer of absorbent terrycloth material, and an outer layer consistent with standard underwear or undergarment materials, typically cotton (i.e., fabric). In one embodiment, the multi-layered portion has varied density to accommodate different levels of protection and comfort.