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44results about How to "Retain activity" patented technology

Semitransparent skin-care face cream based on medium-temperature hot pot process as well as preparation method and application of semitransparent skin-care face cream

The invention discloses a semitransparent skin-nourishing face cream based on a medium-temperature hot pot process and a preparation method and application thereof, belongs to the technical field of cosmetics, and aims at solving the problems that in the prior art, in the face cream preparation process, a high-temperature processing process can destroy the activity of natural extracts; and the technical problem of how to enable the face cream to be semitransparent through formula system combination is solved. The preparation method of the semitransparent skin-care face cream based on the medium-temperature hot pot process comprises the following steps: putting a phase A into an emulsifying pot, and stirring and heating to 80-85 DEG C; adding the phase B into the emulsifying pot, stirring and heating to 80-85 DEG C, and then cooling to 60-65 DEG C; sequentially adding the phase A, the phase B, the phase C and the phase D into an emulsifying pot to enable the materials to be uniform, and cooling the materials to 53-57 DEG C to obtain cream; and filling the cream to obtain the prepared semitransparent skin-nourishing face cream based on the medium-temperature thermal tank process. The semitransparent face cream is prepared by designing a component compounding system.
Owner:澳亚化妆品研究开发(广州)有限公司

A grinding and pulverizing device for the production of ester raw materials

ActiveCN224423066UReduce energy consumptionInhibition of thermal degradationProcess engineeringBall mill
This utility model discloses a pulverizing and grinding device for the production of ester raw materials, including a main support unit, a ball mill at the top of the main support unit, a secondary pulverizing device on one side of the main support unit, a material collection unit at the top feed end of the secondary pulverizing device, and the discharge end of the ball mill above the material collection unit, allowing the discharge from the ball mill to enter the material collection unit. Air nozzles and air outlets are provided on both side walls of the secondary pulverizing device, and sealed conveying units are provided at both the top feed end and the bottom discharge end of the secondary pulverizing device. This utility model addresses the problems of localized temperature rise in existing grinding equipment leading to thermal decomposition of ester raw materials and insufficient grinding precision. It employs multi-stage pulverization, coarsely pulverizing followed by ultrafine grinding, reducing the energy consumption of a single device. Furthermore, a low-temperature medium is introduced during the fine grinding process for cryogenic pulverization or low-temperature grinding, inhibiting the thermal degradation of esters, thus meeting the high standards required in the food, pharmaceutical, and other fields.
Owner:HANGZHOU RUILIN CHEM IND CO LTD

Gingko, dendrobium officinale and ginseng plant beverage crushing, mixing and preparing equipment

The invention belongs to the technical field of plant beverage processing, and particularly relates to a gingko, dendrobium officinale and ginseng plant beverage crushing, mixing and preparing device which comprises a mixing and preparing machine, a universal pulverizer, an ultrafine pulverizer, a freezing pulverizer and a high-pressure homogenizer, and the mixing and preparing machine comprises a material cavity, a feeding opening, a discharging opening and a stirring mechanism; the preparation method of the mixing preparation machine comprises the following preparation steps: S1, raw material pretreatment: selecting ginkgo leaves, fresh dendrobium officinale strips and ginseng rhizomes which are free of mildew and diseases and insect pests, cleaning the ginkgo leaves, drying the ginkgo leaves with hot air, removing fibrous roots from the fresh dendrobium officinale strips, cutting the fresh dendrobium officinale strips into long sections, peeling the ginseng rhizomes, and cutting the peeled ginseng rhizomes into long slices; s2, graded crushing is conducted, specifically, the pretreated ginkgo leaves are put into a universal pulverizer to be pulverized and then transferred into an ultrafine pulverizer to be further pulverized into fine particles, and the device solves the problems that when the ginkgo, dendrobium officinale and ginseng plant beverage is prepared through crushing and mixing at present, the mixing effect is poor, and the stability and taste of the beverage are directly affected.
Owner:SINO ITALIAN KYUSHU BIOTECHNOLOGY CO LTD

An integrated system for the extraction and separation of heat-sensitive components from traditional Chinese medicine.

ActiveCN224613223UImprove transfer rateretain activityThermodynamicsSeparation technology
This utility model belongs to the field of traditional Chinese medicine extraction and separation technology. It discloses an integrated system for the extraction and separation of heat-sensitive components from traditional Chinese medicine, including a stirred extraction tank, a cooler, a cyclone centrifuge, a stirring device, a power delivery pump, an ultrasonic generator, and an air-lift device. The stirred extraction tank includes a tank body with a discharge port at the bottom and a jacketed cylinder on the side wall. An annular cavity is left between the jacketed cylinder and the tank body, with an inlet and an outlet on the cavity. The tank body is vertically arranged with multiple support legs. A first and second inlet are also provided at the top of the tank body. A stirring device is installed at the top of the tank body. Multiple ultrasonic generators are annularly installed along the side wall of the tank body. The cooler is located on one side of the stirred extraction tank. This utility model integrates stirring and ultrasonic extraction, jacketed hot and cold circulation, and a rapid liquid-residue separation system, significantly improving the extraction efficiency of effective components from traditional Chinese medicine, shortening the extraction time, and effectively protecting the activity of heat-sensitive components.
Owner:HONGHE VOCATIONAL & TECH COLLEGE

Preparation method of inositol nicotinate tablets

ActiveCN121754494Aevenly dispersedAvoid risk of degradationOrganic active ingredientsMetabolism disorderDrug contentCoated drugs
The invention discloses a preparation method of inositol nicotinate tablets, and belongs to the technical field of pharmaceutical preparations. By optimizing the existing process and coating components, stable dissolution of drugs is realized, and the method comprises the following steps: dispersing inositol nicotinate in mixed oil to prepare an oil phase, mixing and emulsifying the oil phase and a water phase, performing spray drying to obtain drug milk powder, coating the drug milk powder with modified chitosan, and directly tabletting the coated drug milk powder and auxiliary materials. The preparation method comprises the following steps: uniformly dispersing inositol nicotinate in mixed oil to promote the inositol nicotinate to maintain the uniformity of the drug content in the subsequent process, and adsorbing solid particles on the surfaces of drug-containing oil drops through an emulsification technology to protect the drug components; coating components are reasonably designed, so that fixed-point release of the medicine is realized, the medicine is endowed with anti-pressure ability, and the medicine can be directly tableted; and the coated medicine particles are mixed with auxiliary materials and then are directly tableted, so that the process is simplified, and the coating structure of the medicine particles is protected at the same time. The preparation method can prepare the inositol nicotinate tablet with stable drug dissolution, and the inositol nicotinate tablet is good in taste and small in stimulation to gastric mucosa.
Owner:JILIN XIANFENG TECH PHARM CO LTD

A process for the continuous preparation of mirabegron in a microchannel reactor

ActiveCN121270488BHigh reaction safetyshort reaction time
This invention discloses a stepwise continuous flow method for preparing Miraberon using a microchannel reactor. Specifically, the method involves synthesizing Miraberon from p-nitrophenylethylamine hydrochloride and D-mandelic acid, followed by amide condensation, borane reduction, hydrogenation reduction, and a second amide condensation reaction to obtain the target product. Each step utilizes a continuous flow process for intermediate synthesis. This invention offers high reaction safety, short reaction time, and simple post-processing. It fundamentally eliminates the safety hazards caused by hydrogen leakage, reduces catalyst friction loss due to stirring in batch reactions, and avoids catalyst contact with air during post-processing, thus preserving catalyst activity, improving catalyst utilization efficiency, and significantly reducing economic costs.
Owner:ZHEJIANG UNIV OF TECH

Preparation method of a rhizoma polygonati enzyme liquid

PendingCN122074642AImprove creativityretain activityFungiBacteriaBiotechnologyEnzymatic hydrolysis
This invention discloses a method for preparing Polygonatum sibiricum enzyme liquid, belonging to the field of bio-fermentation technology. The method includes: gradient permeation activation treatment of Polygonatum sibiricum, including negative pressure pulsating permeation and reduced pressure concentration under inert gas protection; preparation and co-inoculation of a composite strain of Lactobacillus plantarum and Saccharomyces cerevisiae propagated in a stepwise sequential manner; multi-stage temperature and pressure-coupled fermentation, including pressurized microaerobic primary fermentation and high-temperature static incubation for enhanced conversion; targeted induction of enzymatic hydrolysis and low-temperature maturation; and in-situ aseptic filling. This invention does not add any other ingredients throughout the entire process. Through a series of original, interrelated process steps and precise parameter control, it solves the technical problem of efficiently converting a single Polygonatum sibiricum raw material into a high-quality enzyme liquid, ultimately producing a pure Polygonatum sibiricum enzyme liquid with high active substance content, mellow taste, and excellent stability.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

A hydrogel microneedle patch based on bletilla striata polysaccharide composite engineered exosome and a preparation method and application thereof

The application discloses a kind of hydrogel microneedle patches based on bletilla striata polysaccharide composite engineered exosome and its preparation method and application, belong to the technical field of biomedical materials, with bletilla striata polysaccharide and methacrylated hyaluronic acid as matrix, and the hydrogel microneedle with excellent mechanical properties is prepared.The natural polyphenol caffeic acid is used to modify the bone marrow mesenchymal stem cell exosome, and the engineered exosome is loaded on the microneedle tip by centrifugation.The strong antioxidant capacity of caffeic acid is used to protect the structure of exosome, and a synergistic system is formed, combined with the antibacterial and anti-inflammatory properties of the bletilla striata polysaccharide matrix itself, the diabetic wound microenvironment can be improved from multiple dimensions such as bacteriostasis, antioxidant, anti-inflammatory and pro-angiogenesis.The preparation process of the application is simple and controllable, the product has high biological safety, and the active ingredients can be delivered precisely and minimally invasively, providing an efficient and safe solution for diabetic chronic wound repair.
Owner:NANJING DRUM TOWER HOSPITAL

A method for preparing enteric slow-release defensin mesoporous silica nanoparticles

The application discloses a preparation method of enteric sustained-release defensin mesoporous silica nanoparticles. The enteric sustained-release defensin mesoporous silica nanoparticles prepared by the method have good defensin loading capacity, good responsiveness to trypsin and good enteric targeting and sustained-release defensin performance.
Owner:ARMY MEDICAL UNIV

Extraction process of citrus essential oil and citrus essential oil prepared by extraction process

The invention discloses an extraction process of citrus essential oil and the citrus essential oil prepared through the extraction process, and belongs to the field of natural perfume extraction.The extraction process of the citrus essential oil comprises the following steps that S1, peel of disinfected and cleaned fresh citrus fruits is obtained; s2, sequentially crushing and squeezing the fruit peels under the assistance of ultrasonic waves or without ultrasonic waves, and then separating out solid matters to obtain virgin juice; and S3, standing and layering the virgin juice in an environment of 0-10 DEG C, then centrifuging at a controlled temperature at a centrifugal speed of 2000-60000r / min for 1-180min, and separating out upper-layer essential oil within 30min after centrifugation is finished, so as to obtain the citrus essential oil. The process can improve the essential oil yield, reduce the water content and maintain the natural fragrance close to that of fresh fruits, and can be applied to the field of food and the field of daily chemicals.
Owner:GUANGDONG QINTIAN FOOD CO LTD

Method for quantitatively detecting bisphenol pollutants in soil and root traditional Chinese medicines based on magnetic MOF (at) COF porous composite material combined with LC-MSMS

The invention belongs to the technical field of magnetic solid-phase extraction and analysis. The invention provides a method for quantitatively detecting bisphenol pollutants in traditional Chinese medicines for soil and roots based on a magnetic MOF (at) COF porous composite material combined with LC-MSMS. The method comprises the steps of preparation of the magnetic MOF (at) COF porous composite material, sample pretreatment and LC-MSMS detection and quantitative analysis. The magnetic MOF (COF) porous composite material disclosed by the invention has rich hierarchical pore structures and high specific surface area, not only retains regular pore channels and active sites of a metal organic framework (MOF), but also is connected with a covalent organic framework (COF), so that the stability of the material is greatly improved. Meanwhile, the material is mild in preparation condition, low in cost and excellent in adsorption performance. Compared with the existing method, the detection method provided by the invention has the advantages of more thorough extraction, lower detection limit, higher recovery rate, simpler operation and lower cost, and is suitable for two matrixes of soil and root system traditional Chinese medicines.
Owner:SICHUAN FORESTRY RES INST (SICHUAN FORESTRY IND RES & DESIGN INST)

Equipment and method for concentrating ginsenoside extracting solution

InactiveCN121988049AEnsure a high degree of homogenizationimprove consistencyEvaporator accessoriesProcess engineeringChemistry
The invention relates to the technical field of concentration equipment, and particularly discloses equipment and a method for concentrating a ginsenoside extracting solution. A concentration unit; a dispersing unit; an eccentric suction unit; and a heating unit. According to the invention, through circumferential stirring of the dispersing unit and reciprocating circulation action of the eccentric suction unit, multi-dimensional space turbulent flow is realized for extracting solutions of different levels in the concentration container, the layering phenomenon of heavy component sinking and light component floating is forcibly broken, and high homogenization of the extracting solutions in the whole concentration process is ensured, so that the concentration effect consistency is improved, and the concentration efficiency is improved. The stability of the content of ginsenoside in different batches of products is ensured; meanwhile, heat is quickly and uniformly distributed in the liquid due to continuous physical disturbance, so that degradation or charring of a heat-sensitive ginsenoside component caused by local overheating is avoided, and the activity of a target component is reserved to the greatest extent.
Owner:SHENYANG TENLLE HEALTH FOOD & COSMETICS CO LTD

Traditional Chinese medicine beverage capable of soothing nerves, helping sleep and regulating emotion and preparation method of traditional Chinese medicine beverage

PendingCN121846222APromote dissolutionImprove broken rateNervous disorderDispersion deliveryEleutherococcus senticosusEleutheroside
The invention discloses a traditional Chinese medicine beverage capable of soothing nerves, helping sleep and regulating emotion and a preparation method thereof, and particularly relates to the field of traditional Chinese medicine pharmaceutics. The beverage realizes sleep aiding through jujuboside, spinosin, eleutheroside, cyclic adenosine monophosphate and the like, regulates emotion through fingered citron lactone, rose volatile oil and the like, and tranquilizes and stabilizes mind by using hericium erinaceus, hawthorn flavone and the like. The preparation method comprises the following steps: carrying out differential pretreatment on raw materials; volatile oil, water-soluble functional components and flavor substances are obtained through circulating percolation extraction, dynamic countercurrent extraction and mild extraction by adopting a stepped directional extraction process; and precisely filtering and clarifying the extracting solution through a ceramic membrane, compounding with aromatic volatile oil, and sterilizing and filling by adopting a 550MPa ultrahigh-pressure cold sterilization technology. The method overcomes the defects of low extraction efficiency and easy loss of active components in the traditional process, realizes efficient synergistic extraction and complete retention of various active components, and has the advantages of fresh taste, stable character, long shelf life and accurate and controllable process parameters.
Owner:ZHEJIANG SHUNQIYI MEDICAL TECHNOLOGY CO LTD

Preparation method of immunoglobulin powder and application thereof

PendingCN122255259Aresolve failureretain activityPowder deliveryMilk immunoglobulinsMilk SerumIntravenous gammaglobulin
The present application relates to a kind of preparation method of immunoglobulin powder and its application, the preparation method includes the following steps: collecting bovine colostrum, using cell survival technology is frozen;Frozen bovine colostrum is thawed, carries out milk fat separation, and obtains defatted bovine colostrum;Defatted bovine colostrum and composite rennet are mixed and are curdled, and then broken, obtain whey;The composite rennet includes aspartic protease, papain and bromelain;Whey is ultrafiltrated, and immunoglobulin solution is obtained;Immunoglobulin solution is vacuum freeze-dried, and the immunoglobulin powder is obtained.The preparation method provided by the present application is low temperature all the way, the activity of immunoglobulin is retained to the greatest extent, the use of composite rennet solves the problem of curd failure, and each link cooperates to improve the curd effect, realizes the preparation of high-efficiency, high-purity and high-quality immunoglobulin powder.
Owner:INNER MONGOLIA MENGNIU DAIRY IND (GROUP) CO LTD

Reagent for photo-induced chemiluminescence detection, kit and preparation method thereof

This application relates to a reagent, kit, and preparation method for photochemiluminescence detection. The reagent comprises an acceptor capable of reacting with singlet oxygen to generate a detectable signal, a first biomolecule binding to the acceptor, and a biotin-labeled second biomolecule. The biomolecule specifically binds to the analyte. The biotin is directionally labeled onto the biomolecule using a Catcher-Tag system. The technical solution of this application provides a detection reagent with high sensitivity and strong anti-hooking ability, which can improve the abundance of photochemiluminescence detection signals and the accuracy of detection results.
Owner:BEYOND DIAGNOSTICS (SHANGHAI) CO LTD +1

A combined detection kit for pepsinogen i and pepsinogen ii and application thereof

This application relates to the technical field of bioassay, specifically disclosing a combined detection kit for pepsinogen I and pepsinogen II and its application. The disclosed combined detection kit for pepsinogen I and pepsinogen II includes: a sample pad, a conjugate pad, a coating membrane, and an absorbent pad; the coating membrane is an NC membrane coated with antibody; the conjugate pad is prepared by pretreating and drying a fiber membrane, followed by spraying time-resolved fluorescent microspheres labeled with antibody; the pretreating solution is a solution of pH 8.0-8.4 + 8-12mM BS + 0.8-1.2% BSA + 0.8-1.2% PEG4000 + 0.02-0.03% surfactant + 4-6% sucrose. Using the detection kit and method provided in this application for the combined detection of pepsinogen I / pepsinogen II exhibits high sensitivity, accuracy, and repeatability.
Owner:QINGDAO HUAJING BIOTECHNOLOGY CO LTD

Immune cell culture perfusion device

InactiveCN121975620AAvoid Growth Difference Problemshigh activityBioreactor/fermenter combinationsBiological substance pretreatmentsEffective surface areaBiomedical engineering
The invention belongs to the technical field of immune cell culture perfusion, and particularly relates to an immune cell culture perfusion device which comprises a base, a plurality of culture trays are arranged at the top of the base, fixing blocks are mounted at the bottoms of the culture trays in an inserted mode, a supporting rod is rotatably mounted at the top of the base, a sliding groove is formed in the supporting rod, and a lifting plate is slidably mounted in the sliding groove. A pump body is fixedly mounted at the top of the lifting plate, a water outlet pipe is fixedly mounted at the water outlet end of the pump body, the bottom end of the water outlet pipe penetrates through the lifting plate and is fixedly provided with a plurality of connecting pipes, and atomizing nozzles are fixedly mounted at the bottom ends of the connecting pipes and are located in the culture trays respectively, and a water inlet pipe is fixedly mounted at the water inlet end of the pump body; the sprayed culture medium can be uniformly attached to the inner wall of the culture disc, compared with the situation that the culture medium is locally gathered in a traditional device, the effective surface area of the culture medium in the culture disc is remarkably increased, and the contact efficiency of immune cells in the culture disc and the culture medium can be greatly improved through the larger surface area.
Owner:JIANGSU YIZE BIOTECHNOLOGY CO LTD

Plant extraction compound factor with anti-inflammatory and anti-allergy functions and preparation method of plant extraction compound factor

The invention provides a plant extraction compound factor with anti-inflammatory and anti-allergy functions and a preparation method thereof, and relates to the technical field of skin care product processing, the plant extraction compound factor is prepared from the following raw materials by weight: 8-10 parts of gentiana macrophylla, 5-7 parts of swertia mileensis, 4-6 parts of stephania tetrandra, 6-8 parts of phellinus igniarius, and 7-9 parts of peony. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 5-7 parts of eucommia ulmoides, 4-6 parts of magnolia sieboldii, 6-8 parts of andrographis paniculata and 3-5 parts of polygala tenuifolia, and the plant extraction compound factor is prepared from the following raw materials in parts by weight: 8-10 parts of centella asiatica, 3-5 parts of bamboo shavings, 5-7 parts of fructus forsythiae and 4-6 parts of amur corktree. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 3-5 parts of coreopsis tinctoria, 7-9 parts of liquorice, 2-4 parts of pelargonium graveolens and 3-5 parts of broom leaf Australian tea.
Owner:XIAN TIANKANG BIOTECHNOLOGY CO LTD

Product extraction device for producing acetone through synthesis gas pressure fermentation

ActiveCN224133049UImprove vaporization efficiencyretain activitySemi-permeable membranesBioreactor/fermenter combinationsProcess engineeringFermentation broth
The utility model relates to a product extraction device for producing acetone through synthesis gas pressure fermentation, which comprises a synthesis gas pressure fermentation tank, a membrane filtration unit, a reduced pressure flash tank, a gas condensation pipe and an acetone storage tank, a liquid inlet of the membrane filtration unit is communicated with a fermentation liquid discharge port, and a reflux inlet of the membrane filtration unit is communicated with the fermentation tank; a liquid inlet of the reduced-pressure flash evaporation pipe is communicated with a liquid outlet of the membrane filtration unit; a gas inlet of the gas condensation pipe is communicated with a vapor phase outlet of the vacuum flash tank; and a condensate outlet of the gas condensation pipe is communicated with an acetone storage tank. According to the product extraction device, firstly, thalli of fermentation liquor are intercepted through the membrane filtration unit, the activity of the thalli is reserved, and the influence on the activity of the thalli is low; according to the invention, acetone is used as a raw material, then the reduced pressure flash tank is used for reducing the pressure of the fermentation liquid and then flash evaporation is carried out, the temperature is maintained at 60 DEG C by using fermentation waste heat, so that the acetone is rapidly vaporized to form gas-liquid two-phase flow, and the design not only improves the vaporization efficiency of the acetone, but also reduces the additional cooling requirement and reduces the energy consumption.
Owner:JITILABO (BEIJING) BIOTECHNOLOGY DEV CO LTD

Mussel mucoprotein-agarose composite hydrogel as well as preparation method and application thereof

The invention relates to the technical field of medical biological materials, and discloses mussel mucoprotein-agarose composite hydrogel and a preparation method and application thereof.The preparation method comprises the steps that agarose powder is dispersed in an aqueous solvent and heated to 80-100 DEG C to be completely dissolved, and a clear agarose solution is obtained; cooling the agarose solution to 40-60 DEG C, and keeping the agarose solution in a liquid state; the preparation method comprises the following steps: dissolving mussel mucin powder in an aqueous solvent or a buffer solution to prepare a mussel mucin solution, and slightly heating (1t, 40 DEG C) to promote dissolution; uniformly mixing the agarose solution obtained in the step S2 and the mussel mucoprotein solution obtained in the step S3 at 40-60 DEG C, and avoiding introducing bubbles to obtain a mixture; cooling the mixture to room temperature or body temperature to form composite hydrogel; carrying out irradiation sterilization on the composite hydrogel; the hydrogel is simple to prepare, has the thermal reversible gel characteristic, has good tissue adhesion and biocompatibility, and can effectively maintain the biological activity of the two natural components.
Owner:RUIFUXIN (SUZHOU) MEDICAL TECHNOLOGY CO LTD

Traditional Chinese medicine composite meal replacement powder with metabolic regulation function and production process thereof

PendingCN122074643AActively regulate metabolismMeet daily nutritional needsMetabolism disorderFood scienceBiotechnologyNutrition
The invention belongs to the technical field of health food and traditional Chinese medicine health preservation, and particularly relates to traditional Chinese medicine composite meal replacement powder with a metabolic regulation function and a production technology thereof.The meal replacement powder is prepared from, by weight, 35%-55% of traditional Chinese medicine conditioning components and 45%-65% of modern functional raw materials, and 0.15%-0.7% of auxiliary components can be selectively added; the traditional Chinese medicine conditioning components comprise 13 medicinal and edible raw materials such as ginseng and poria cocos, the modern functional raw materials comprise purified konjaku flour and skimmed whey protein, the calorie of the product is less than or equal to 150kcal / 100g, the dietary fiber is greater than or equal to 15g / 100g, and the protein is greater than or equal to 12g / 100g; the production technology comprises the steps of raw material pretreatment, graded mixing, low-temperature sterilization and sterile packaging, low-temperature drying and superfine grinding are adopted in the pretreatment, graded stirring is adopted in the mixing, and ultrahigh-temperature instant sterilization is adopted in the sterilization. The defects that existing meal replacement powder is prone to metabolic disorder and body weight rebound are overcome.
Owner:李柯萦

A method for encapsulating enzymes in situ with lignin

ActiveCN120118896BHigh encapsulation rateretain activityHydrolasesOn/in organic carrierCelluloseBiomanufacturing
The application discloses a method for in-situ encapsulating enzyme by lignin. The pH of industrial lignin water dispersion is adjusted to above 10.0 to dissolve the industrial lignin, and the industrial lignin solution is obtained after filtering and removing impurities. Then the pH of the industrial lignin solution is adjusted to 5-9.5, and enzyme protein is added to obtain a mixed solution. The pH of the mixed solution is adjusted to 3.0-4.0 again, so that the industrial lignin and the enzyme protein are co-precipitated. After separating the precipitate, drying is performed to obtain the immobilized enzyme. The application uses the adsorption capacity of lignin to enzyme and the property of alkali-soluble acid-extractable of lignin to immobilize the enzyme with low pH sensitivity, so that the encapsulation rate of the enzyme is improved, and the activity of the immobilized enzyme is better preserved. The application provides a new method for in-situ encapsulating enzyme protein, and has a positive significance for promoting the development of lignocellulose bio-refining and green bio-manufacturing.
Owner:SOUTH CHINA AGRICULTURAL UNIVERSITY

A medicinal herb and aloe vera swelling microneedle patch and a preparation method and application thereof

PendingCN122537287AAchieve deep deliveryReduce onset time
This invention belongs to the field of pharmaceutical technology and relates to a drug-excipient combined Senecio scandens swelling microneedle patch, its preparation method, and its application. This invention innovatively uses the extract of the traditional Chinese medicine Senecio scandens as the active ingredient, while utilizing its molecular properties to participate in the construction of the microneedle framework, realizing the design concept of "drug-excipient integration." Combined with cross-linking technology, the drug loading capacity of the microneedles in this invention can reach 40-45 wt%, greatly increasing the drug dosage per unit area patch and meeting the demand for high-dose drugs in the acute phase of Alzheimer's disease (AD). This invention forms a stable gel framework through physical and chemical dual cross-linking, giving the microneedles the characteristic of "swelling without dissolving." After drug administration, the water-absorbing and swollen matrix framework can be completely peeled off with the substrate, leaving no synthetic polymers in the body, greatly improving the safety of clinical use, and is especially suitable for patients with chronic skin diseases requiring long-term, repeated drug administration.
Owner:NINGBO HOSPITAL OF TRADITIONAL CHINESE MEDICINE +1

Full-automatic bionic rolling robot and system for tea manufacturing

The invention relates to the technical field of tea manufacturing, and discloses a full-automatic bionic rolling robot and system for tea manufacturing, the full-automatic bionic rolling robot comprises a frame, the top of the frame is fixedly connected with a transverse plate, the top of the frame is provided with a rolling mechanism, the rolling mechanism comprises a fixing column, the fixing column is fixedly connected to the middle of the lower side of the transverse plate, and the transverse plate is fixedly connected with the fixing column. A fluted disc is fixedly connected to the bottom of the fixing column, rotating shafts are rotationally connected to the left side and the right side of the bottom of the transverse plate, a first motor is fixedly connected to the right side of the top of the transverse plate, and the output end of the first motor penetrates through the transverse plate and is fixedly connected with the rotating shaft on the right side. A linkage structure of the first movable plate, the second movable plate and the supporting ring is arranged, meshing transmission of the gear ring and the fixed fluted disc is matched, the bionic hand can automatically rotate while revolving around the center, the combined action of pushing and kneading of the palm in the manual tea making process is simulated, the effective contact area with tea leaves is increased, and kneading is more uniform.
Owner:ZHONGFUHEHE (KUNSHAN) TEA CO LTD

Dairy product non-destructive ordered resolution method and applications thereof

PendingCN122642476Aretain activityreduce waste
The present application relates to the field of dairy processing, and particularly relates to a dairy product lossless ordered analysis method and application thereof, which sequentially separates raw cow milk into cream and skim milk through fat separation, ion exchange chromatography, microfiltration membrane separation and other processes, and gradually extracts high-value-added components such as lactoferrin, lactoperoxidase, casein and whey protein, while co-producing 12 kinds of dairy products such as Mascarpone cheese, sterilized cream and Brie cheese. The method of the present application adopts an ordered analysis process of multi-technology integration, realizes efficient utilization of all components of cow milk, solves the problems of resource waste and single product in traditional processing, and through integrated design, simultaneously obtains high-value active ingredients (such as lactoferrin powder) and basic raw materials (such as lactose powder) in a single production line, significantly improves the utilization rate of milk resources to more than 90%, and has economic benefits and sustainable development advantages, providing an innovative solution for high-value processing of dairy products.
Owner:INNER MONGOLIA MENGNIU DAIRY IND (GROUP) CO LTD

A dental implant with a high-bioactivity surface coating and a method for preparing the same

The application relates to the field of implant technology, and particularly relates to a dental implant with a high-bioactivity surface coating and a preparation method thereof; in order to improve the bioactivity of a dental implant and improve the healing condition of the dental implant after implantation, the dental implant surface is first subjected to sand blasting treatment for roughening and acid liquid and alkali liquid immersion treatment, the content of hydroxyl groups on the surface of the dental implant is increased, the hydrophilicity of the dental implant is improved, the content of active groups on the surface of the dental implant is increased, and on this basis, a polydopamine coating containing exosome microcapsules is introduced into the surface of the dental implant, so that the antibacterial performance of the dental implant is improved and the proliferation of cells is induced, the implantation of the dental implant is accelerated, and the bioaffinity of the dental implant is greatly improved.
Owner:CHIFENG MUNICIPAL HOSPITAL

Coconut juice rice milk beverage and processing method thereof

PendingCN122004375ApH increaseprevent coagulationFood scienceBiotechnologyCoconut oil
The invention relates to the technical field of food processing, in particular to a coconut juice and rice milk beverage and a processing method thereof.The method comprises the steps that rice is taken, baking soda is added, and soaking is conducted overnight; pouring the soaked rice and water into a colloid mill, and grinding to obtain raw rice milk; adding the raw rice milk, the coconut milk and the white granulated sugar into a stirring tank at the same time, stirring and mixing, and blending; stirring and gradually heating in the blending process, and finally keeping stirring at 85-95 DEG C, so that starch is dissolved out and compounded with lipid, and the rice milk gradually becomes rice paste; when rice milk is gelatinized at 85-95 DEG C, the stage is the optimal window stage of starch dissolution and lipid compounding, starch particles absorb water to swell and break, amylose is dissolved out, coconut milk fat molecules added in advance before the rice milk is gelatinized can be combined with hydrophobic cavities of the amylose at the moment, and the amylose is dissolved out. The formed single-helix compound blocks mutual approaching and hydrogen bond bonding among amylose molecules, reduces the aging of starch, and also can avoid rancidity generated by oxidation of coconut oil.
Owner:FUJIAN SALT IND GROUP CO LTD

A wettable powder and a method for preparing the same

PendingCN122581299ARapid self-wettingImprove disease prevention and control
The application discloses a wettable powder and a preparation method thereof, and belongs to the technical field of microbial preparations. The powder is prepared by compounding one or more kinds of microbial spores of Trichoderma harzianum, Penicillium bilaiae, Aspergillus niger and Paecilomyces lilacinus as core raw materials, and a wetting agent and a carrier. The special wetting agent can effectively improve the self-wetting effect of various spore powders, realizes quick wetting of the powder in water, and no floating and caking. The carrier can flexibly dilute the spore raw material, and is suitable for the production requirements of products with different viable bacterial contents, and the product has strong adaptability. The preparation process is simple, the product has excellent wetting performance and stable properties, can be effectively used for agricultural soil improvement and crop soil-borne disease prevention and control, and has extremely high agricultural application value.
Owner:QINGDAO UNIV OF SCI & TECH

A drying color protection process of purple bamboo shoots rich in anthocyanins

PendingCN122250609APreserve sensory qualitiesretain nutritional valueFruits/vegetable preservation by dehydrationVitamin CVitamin
The application provides a kind of dry color protection process of purple Germinatus Bambusae Sinospinosae rich in anthocyanins, and the steps include: selecting fresh and intact purple Germinatus Bambusae Sinospinosae with a length of 25-45 cm, removing the shell, washing with clean water, then absorbing the surface water with clean gauze, cutting into uniform size bamboo shoots, bamboo shoot silk and bamboo shoot strips; at room temperature, immerse the treated purple bamboo shoot samples in different concentrations of color protection solution for 1-10 min, the color protection solution includes 0.1-3.0% CaCl2, 0.1-3.0% L-cysteine, 0.01-2.0% vitamin C, then take out and drain water; dry the purple Germinatus Bambusae Sinospinosae after draining water at a temperature of 50-70℃, after reaching the drying endpoint, take out and cool to room temperature, then vacuum package, put the packaged bamboo shoots into self-sealing aluminum foil bags, and store at room temperature. The purple Germinatus Bambusae Sinospinosae treated by the application can maintain good sensory quality, and the anthocyanin content and activity can be better preserved, ensuring the quality and value of the purple Germinatus Bambusae Sinospinosae.
Owner:SICHUAN AGRI UNIV