100 results about "Arbutin" patented technology

The invention provides anti-aging moisturizing essence and a preparation method thereof, and belongs to the technical field of cosmetics. The essence is prepared from a plant extract, sodium pyrrolidone carboxylate, hexapeptide, nicotinamide mononucleotide, vitamin B5, galactose yeast fermentation product filtrate, b-glucan, sodium hyaluronate, glycerol, tranexamic acid, blue copper peptide, arbutin, nicotinamide, vitrin, a bifidus yeast fermentation product, a bifidus yeast fermentation lysate and the like. Wherein the plant extract is prepared by mixing rosemary, frankincense resin, tea flowers, sandalwood and jasmine flowers through ultrasonic extraction, comprehensive skin care is achieved from multiple angles of anti-aging, whitening, moisturizing and repairing, the overall health of the skin is guaranteed, and the skin care cream is suitable for various skin types.

The invention belongs to the technical field of cosmetics, and particularly relates to a silk fibroin aggregate-based dispersed organic active substance as well as a preparation method and application thereof. The preparation method of the silk fibroin aggregate-based dispersed organic active substance comprises the following steps: (1) dissolving an organic active substance in a first solvent to obtain a first solution; dissolving the silk fibroin aggregate in a second solvent to obtain a second solution; (2) slowly adding the second solution into the first solution, mixing and homogenizing to obtain a silk fibroin aggregate-based dispersed organic active substance; wherein the silk fibroin aggregate is prepared by mixing a silk fibroin aqueous solution and alcohol. The silk fibroin aggregate-based dispersed organic active substance prepared by the preparation method can improve the bioavailability of the organic active substance (such as vitamin C, hyaluronic acid, coenzyme Q10, nicotinamide, arbutin, kojic acid, licorice extract, centella extract, chamomile extract or green tea extract) in cosmetics.

The invention provides a whitening and anti-aging extracellular vesicle compound as well as a preparation method and application thereof. The extracellular vesicle compound comprises extracellular vesicles derived from mesenchymal stem cells and active ingredients loaded in the extracellular vesicles, the active component comprises any one or a combination of at least two of retinoic acid, arbutin, panthenol, nicotinamide, ectoine, vitamine, hyaluronic acid, vitamin C, resveratrol or retinol; the ratio of the extracellular vesicles to the active ingredients is (1-10) * 10 < 8 >: (0.01-1) mg. The skin-care active ingredients are entrapped in the extracellular vesicles derived from the mesenchymal stem cells, so that the delivery efficiency of the skin-care active ingredients can be remarkably improved, the direct irritation of free components to the skin can be reduced, the generation of matrix metalloproteinase-1 (MMP-1) and melanin can be effectively inhibited, the light aging process of the skin can be delayed, and the skin-care composition has excellent whitening and anti-aging effects.

The application discloses application of a complex containing Dendrobium officinale leaf extract in preparation of a whitening and freckle-removing preparation, and the complex comprises the Dendrobium officinale leaf extract, a Rhizoma Polygonati extract and beta arbutin. After the components of the complex are mixed in a specific ratio and fully combined and synergized, the ability of inhibiting tyrosinase activity can be significantly improved by 300%, 175% and 87% respectively compared with the Dendrobium officinale leaf, the Rhizoma Polygonati and the beta arbutin, the melanin generation in zebra fish within 72 hours can be effectively inhibited, the melanin content can be obviously reduced, the melanin inhibition rate is increased by 394%, 532%, 24.14% and 37.39% respectively compared with the Dendrobium officinale leaf group, the Rhizoma Polygonati group, the beta arbutin group and the Dendrobium officinale leaf-Rhizoma Polygonati group, the Dendrobium officinale leaf-Rhizoma Polygonati complex can obviously improve the melanin inhibition rate in zebra fish, the combination of the two and the beta arbutin can make the melanin inhibition rate reach 98.70%, and the whitening and freckle-removing effect of skin can be greatly enhanced.

The invention discloses a method for synthesizing alpha-arbutin through biotransformation, and belongs to the technical field of biochemistry. A gene cloning technology is utilized, sucrose phosphorylase Spase in leuconostoc mesenteroides and sucrose phosphorylase gtfa in bifidobacterium adolescentis are screened and found through a Deep Molecules and DLKcat algorithm on a Uniprot database, novopro is utilized for codon optimization, then the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa are expressed on a plasmid vector PET-28a and are converted into an escherichia coli BL21 (DE3) strain, and the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa in the bifidobacterium adolescentis are obtained. An engineering strain for heterologous expression of the gene is constructed by taking the gene as a chassis cell. According to the process, sucrose and hydroquinone are taken as co-substrates, and bioconversion is carried out under the action of sucrose phosphorylase from different sources to obtain alpha-arbutin.

The application discloses a preparation method of arbutin analogues with high transdermal absorption efficiency, and is characterized in that the method comprises the following steps: under the action of a solvent and a catalyst, compound I and compound II are subjected to esterification to obtain compound III, wherein the compound III is the arbutin analogue. The arbutin (compound I) is used as a raw material, the structure of the arbutin is modified through esterification, the transdermal performance of the arbutin is improved, the bioavailability is increased, and finally the whitening effect is improved.

The invention relates to the technical field of cosmetics, and discloses a herbal probiotic composition with whitening and anti-aging effects and a preparation method thereof. The herbal probiotic composition is prepared from alpha-arbutin, licoflavone, bakuchiol, resveratrol, ellagic acid, a metagen complex, skin micro-ecological prebiotics, sodium phytate, ferulic acid, rosemary polyphenol, polycystic liposome and the balance of a carrier suitable for skin. The herbal probiotic composition disclosed by the invention realizes stable co-delivery of hydrophilic and lipophilic activities and effective retention of cuticles under mild pH, synergistically inhibits blackness, resists oxidation and supports microecology, and improves the effective content and batch-to-batch consistency in the shelf life through metal ion accessibility control, so that the whitening and anti-aging effects are improved.

The invention provides lignan, and belongs to the technical field of medicines. According to the invention, a compound shown as a formula I and a compound shown as a formula II are extracted, separated and identified from schisandra chinensis oil for the first time, and the compound shown as the formula I and the compound shown as the formula II are superior to a positive drug group arbutin in the aspect of inhibiting generation of melanin of mouse skin melanoma cells (B16F10); an inflammatory factor release inhibition experiment research shows that the compound shown in the formula I and the compound shown in the formula II have relatively good activity in the aspect of inhibiting LPS-induced mouse mononuclear macrophage RAW264.7 from releasing IL-6 and TNF-alpha; in a skin irritation experiment, the schisandra chinensis non-saponifiable matter containing the compound shown in the formula I and the compound shown in the formula II is non-irritant to the skin of a white rabbit, and it is proved that the compound shown in the formula I and the compound shown in the formula II can be applied to preparation of whitening and anti-inflammatory products. Formula I; formula II.

The application discloses a mycobacterium maltose transferase Co GlgE and an encoding gene and application thereof.The maltose transferase Co The amino acid sequence of the GlgE is shown as SEQ ID NO.1.The application discloses a maltose transferase Corallococcus derived from mycobacterium sp.EGB Co GlgE, which can disperse maltoligosaccharide with a polymerization degree (DP) X into products with a DP of X ± 2n (X ≥ 3). Co The GlgE has glycosylation modification effects on alpha-arbutin and beta-arbutin, the biological activity of the modified arbutin is significantly improved, and the application value of the arbutin as an additive of whitening skin care products is improved.

The invention discloses a quantum chemical screening method for extracting arbutin, and relates to the technical field of natural product extraction, and the quantum chemical screening method comprises the following steps: constructing an arbutin single-molecule model and a hydrogen bond donor and hydrogen bond receptor single-molecule model by using GaussView software, firstly performing conformation search through MOPAC and molplus programs to obtain a most stable molecular structure, and then extracting the arbutin from the molecular structure; carrying out geometric optimization and single-point energy calculation by utilizing Gaussian; the optimized hydrogen bond donor and hydrogen bond acceptor establish random clusters according to different molar ratios, the random clusters with target molecules are established, a cluster model with an optimal structure is selected for geometric optimization and single-point energy calculation, meanwhile, the binding energy between the eutectic solvent and arbutin is calculated, and IGMH analysis, ESP analysis and AIM analysis are carried out. The invention provides a universal method for green and efficient extraction of active ingredients of natural products.

The invention relates to the technical field of microbial fermentation, and discloses a fermentation composition with a whitening effect and a preparation method and application thereof. According to the application, Chinese rose, a sodium glutamate culture medium and sprouted mung beans are respectively used as fermentation objects, and are fermented by selecting plant lactobacillus and bacillus subtilis to respectively obtain a Chinese rose fermented product, a glutamic acid fermented product and a mung bean sprout fermented product; compared with the prior art, the arbutin fermented product has the advantages that the arbutin fermented product shows more excellent monophenol enzyme inhibition rate and diphenol enzyme inhibition rate which are superior to those of arbutin, particularly, the effect is optimal when the three fermented products are compounded, and a theoretical basis is provided for development and application of whitening cosmetic raw materials and products.

The invention discloses an amylosucrase mutant and application thereof in synthesis of alpha-arbutin, the mutant is obtained by mutation of an amino acid sequence of amylosucrase derived from coprophilobacterium mediterranei, and the amino acid sequence of the mutant is shown as SEQ ID NO.4. The invention further discloses a preparation method of the amylosucrase mutant. Compared with a wild strain, the catalytic activity, the temperature stability and the substrate tolerance of the amylosucrase mutant disclosed by the invention are remarkably improved; the recombinant bacteria constructed by using the recombinant bacteria can be used as a whole-cell catalyst to efficiently catalyze a substrate to synthesize alpha-arbutin in a reaction system containing hydroquinone. Therefore, the amylosucrase mutant disclosed by the invention has a good application prospect.

The invention discloses a whitening and spot-fading composition based on a fermented jasmine flower extract. The whitening and spot-fading composition comprises the following components in parts by mass: 0.1-1 part of a nano emulsifier, 0.5-8 parts of the fermented jasmine flower extract, 0.5-1.5 parts of arbutin and 1-3 parts of tranexamic acid. The nano emulsifier is a mixture of hydrogenated lecithin and phytosterol, the mass fraction ratio of arbutin to tranexamic acid is 0.5: 1, and the fermented jasmine flower extract specifically comprises a jasmine flower extract, a lactobacillus fermentation extract, water, 1, 2-hexanediol and 1, 2-pentanediol. The average particle size of the emulsion is about 256.56 nm through a nano emulsification technology, and compared with a conventional system, the transdermal absorption efficiency of active ingredients such as the jasmine flower extract, arbutin and tranexamic acid can be greatly improved, so that the active ingredients can reach action targets more easily; the problem of non-uniform dispersion caused by component solubility difference can be solved, the active component analysis risk is remarkably reduced, the system stability is improved, and the whitening and spot fading effects are enhanced.

The invention discloses a Sorosil decoction specific chromatogram and a construction method and application thereof, and belongs to the technical field of traditional Chinese medicine analysis and detection. The method comprises the following steps: respectively dissolving reference substances of bergenin, arbutin, glycyrrhizic acid, liquiritin, liquiritigenin and gallic acid in a solvent to obtain reference substance solutions; adding soroxil decoction into a solvent, carrying out ultrasonic extraction, and filtering to obtain a test solution; and injecting the reference solution and the test solution into a high performance liquid chromatograph for detection, taking the specific chromatogram of the reference solution as a reference chromatogram, selecting common peaks from the specific chromatogram of the test solution, and constructing the specific chromatogram of the soroxil decoction. The invention also discloses a Sorosil decoction characteristic spectrum and application thereof. According to the specific chromatogram of the soroxi decoction, rapid identification of the formula of the soroxi decoction can be realized, the method is simple, the research blank of the specific chromatogram in quality control of the classic famous-prescription soroxi decoction and the preparation thereof is filled up, and a powerful guarantee is provided for quality improvement of the classic famous-prescription soroxi decoction.

The invention discloses an amylosucrase mutant and application thereof in synthesis of alpha-arbutin, and belongs to the technical field of genetic engineering. An amylosucrase mutant is obtained through an error-prone PCR technology, the mutant is obtained by mutation on an amylosucrase amino acid sequence derived from coprophilobacterium mediterranei, and the amino acid sequence of the amylosucrase mutant is shown as SEQ ID NO.4. The invention further discloses a preparation method of the amylosucrase mutant. Compared with a wild strain, the amylosucrase mutant disclosed by the invention has higher catalytic activity, temperature stability and substrate tolerance; when the catalyst is added into a hydroquinone-containing reaction system, alpha-arbutin can be efficiently catalyzed and synthesized. Therefore, the amylosucrase mutant disclosed by the invention is suitable for industrial production and has a good application prospect.

The invention discloses construction and application of a recombinant escherichia coli engineering strain with high yield of beta-arbutin, and belongs to the technical field of gene engineering and biological engineering. According to the invention, a key gene for synthesizing beta-arbutin is regulated and expressed by adopting a temperature-sensitive promoter; an enzyme mutant aroGS180F capable of resisting feedback inhibition is introduced; an exogenous phosphoketolase pathway is introduced to enhance E4P supply; an acetic acid branch pathway gene is knocked out, so that the formation of a by-product acetic acid is reduced, and the yield of beta-arbutin of the constructed engineering strain can reach 6.83 g / L. The high-yield beta-arbutin escherichia coli recombinant strain constructed by the invention lays a foundation for the subsequent biosynthesis of beta-arbutin and derivatives, and has potential value and significance for the development of synthetic biology.

The invention relates to the technical field of cosmetic component detection and analysis, and discloses a method for rapidly recognizing arbutin in cosmetics based on surface enhanced Raman spectroscopy, AgNPs sol is prepared by an ascorbic acid oxidation-reduction method, and an SERS sensing interface is constructed through aspartic acid electro-polymerization modification; for different dosage forms of cosmetics, a to-be-detected solution is obtained through methanol extraction and centrifugal filtration purification, the to-be-detected solution and AgNPs sol are mixed and adsorbed, then a Raman spectrum is collected, pretreatment is conducted through combination of multivariate scatter correction and standard orthogonal transformation, characteristic wavelengths are screened through a genetic algorithm-combined interval partial least square method, and detection is achieved through combination of qualitative and quantitative models. Through cooperation of sensing interface specific modification and a data processing technology, the arbutin signal recognition capability is enhanced, matrix interference is eliminated, rapid and accurate detection of arbutin in cosmetics is realized, and the effects of high sensitivity, high specificity and simple and convenient operation are achieved.

The present invention discloses a whitening composition with synergistic effect of short peptide and arbutin and its application. The whitening composition with synergistic effect of short peptide and arbutin comprises arbutin and a short peptide; the short peptide is selected from one or more of AHW, LRY, LWF, CFV and IWC. The whitening composition with synergistic effect of short peptide and arbutin of the present invention produces a synergistic effect by combining a specific short peptide with arbutin, synergistically increasing the inhibitory effect on tyrosinase, so that arbutin can achieve a better tyrosinase inhibition effect at a lower, safer and more stable concentration, and can greatly reduce the use concentration of arbutin, reduce cytotoxicity and improve stability. The whitening composition of the invention has the advantages of low concentration, high efficiency, low toxicity and good stability, and has good application prospects.

The invention provides an anti-aging fusion vesicle as well as a preparation method and application thereof. The fusion vesicle comprises a fusion product of extracellular vesicles derived from mesenchymal stem cells and lipidosome, the liposome comprises a carrier formed by assembling phospholipid, cholesterol and an amphiphilic polymer, a fat-soluble active matter loaded on a hydrophobic layer of the carrier and a water-soluble active matter loaded on a hydrophilic inner cavity of the carrier, the fat-soluble active matter comprises any one or a combination of at least two of retinoic acid, resveratrol or retinol; the water-soluble active matter comprises any one or a combination of at least two of arbutin, panthenol, nicotinamide, ectoine, glassine, hyaluronic acid or vitamin C. The fusion vesicle provided by the invention can significantly improve the delivery efficiency of active skin care components, reduce the direct irritation of free components to skin, effectively inhibit the expression quantity of matrix metalloproteinase-1 and delay the photoaging process of skin, and has an excellent anti-aging effect.

The application discloses a preparation method and application of a nano self-assembly composition of arbutin-berberine, and comprises the following steps: dissolving berberine in methanol at 38-42 DEG C, adding an arbutin super-pure water solution at 38-42 DEG C, and stirring and keeping warm for 0.8-1.2 h to obtain a self-assembly solution; then, the self-assembly solution is subjected to vacuum rotary evaporation and freeze drying in sequence, and the nano self-assembly composition of arbutin-berberine is obtained. The traditional Chinese medicine nano self-assembly system based on arbutin and berberine is successfully constructed, the nanoparticles are spontaneously formed under mild conditions through intermolecular non-covalent interaction, the preparation process is simple and convenient, the conditions are mild, the damage of high temperature and other harsh conditions to active ingredients is effectively avoided, and the process adaptability is high.

The invention relates to the field of daily chemical products, in particular to skin-tendering and freckle-removing essence and a preparation method thereof. The essence is prepared from the following raw materials in percentage by weight: 0.01 to 0.5 percent of alpha-arbutin, 0.01 to 0.5 percent of glabridin, 0.01 to 0.5 percent of asiaticoside, 0.2 to 1.5 percent of an uncaria chinensis leaf extract, 0.2 to 1.5 percent of a phyllanthus emblica leaf extract, 0.2 to 1.5 percent of a beetroot extract, 0.2 to 1.5 percent of a holy basil leaf extract, 5 to 20 percent of polyhydric alcohol, 1 to 3 percent of a solubilizer, 0 to 2 percent of auxiliary materials and the balance of water. Alpha-arbutin, glabridin and asiaticoside are adopted to endow the essence with the effects of whitening, removing freckles, moisturizing, tendering skin and the like, and meanwhile, a large amount of polyhydric alcohols are added to endow the skin with better moisturizing and tendering effects; meanwhile, active ingredients such as uncaria chinensis leaf extract, phyllanthus emblica leaf extract, beet root extract and ocimum shengbasil leaf extract are further added, so that the whitening and freckle removing effects of the essence can be remarkably improved, the updating effect of skin epidermal cells can be effectively improved, and the skin is endowed with a tender effect.

A whitening nanocomposition, a preparation method therefor, and use thereof. The whitening nanocomposition comprises an active ingredient and a nanocarrier. The active ingredient is coated and / or adsorbed by the nanocarrier. The active ingredient comprises the following components: 1-15 parts by weight of α-arbutin, 1-15 parts by weight of nicotinamide, 1-10 parts by weight of 3-o-ethyl ascorbic acid, 0.1-1 part by weight of a Centalla asiatica extract, and 1-5 parts by weight of retinyl palmitate. The nanocarrier comprises the following components: 5-10 parts by weight of an emulsifier, 5-20 parts by weight of a polyol, 0.1-5 parts by weight of a phospholipid, and 40-60 parts by weight of water. The whitening nanocomposition has good skin permeability and retention performance and enables high-concentration enrichment, prolonged retention, and sustained release or controlled release within a target tissue, so as to be effectively taken in by target cells, thereby improving bioavailability and enhancing the whitening effect.

The present application relates to the technical field of daily cosmetic composition, and more particularly to a delivery body of a composition for solving skin aging problem in multiple dimensions, comprising the following raw material components: phospholipid, cholesterol, edge activator, composition and water.The composition for solving skin aging problem in multiple dimensions comprises beta-arbutin, tranexamic acid, sodium hyaluronate, allantoin, vitamin B12 and hydroxyethyl urea.The present application further comprises a preparation for preparing a delivery body gel of the composition for solving skin aging problem in multiple dimensions, comprising the above-mentioned composition delivery body, carbomer and cosmetically acceptable adjuvants and solvents.The delivery body gel is convenient to use, easy to adhere to the skin, easy to apply, has strong skin penetration, can penetrate into deep skin, and has excellent synergistic antioxidant, anti-inflammatory, anti-black, anti-aging and other effects.

The invention discloses an arbutin derivative 6-O-Caffeoylbutin as well as a preparation method and application of the arbutin derivative 6-O-Caffeoylbutin. The structural formula of a 6-O-Caffeoylbutin compound is as shown in formula (I). The invention also discloses the application of the arbutin derivative (6-O-Caffeoylbutin) disclosed by the invention in preparation of an antioxidant preparation. According to the invention, the 6-O-Caffeoylbutin extracted for the first time shows excellent antioxidant activity, the ABTB free radical scavenging capacity of the 6-O-Caffeoylbutin is higher than that of ascorbic acid and beta-arbutin, and a material basis is provided for developing novel antioxidants.

The invention discloses a cosmetic composition with blue light resistance and multiple skin protection effects and application of the cosmetic composition. Comprising the following components: water, butanediol, glycerol, nicotinamide, erythritol, hexanediol, p-hydroxyacetophenone, alpha-arbutin, tranexamic acid, glycosylglycerol, carbomer, hydrolyzed collagen, a ganoderma lucidum extract, allantoin, euglena tiny polysaccharide, carnosine and 3-o-ethyl ascorbic acid. The synergistic relationship of various active ingredients in blue light-induced injury is researched, and it is found for the first time that the cosmetic composition has remarkable effects in the aspects of reducing blue light-induced oxidation pressure, relieving chromatosis, improving skin barrier stability and improving dark skin color; the cosmetic composition is used for preparing cosmetics with the effects of resisting blue light, whitening and brightening, and shielding and repairing, and can effectively resist blue light damage and improve the comprehensive state of skin.

The invention discloses a separation method of extracellular vesicles derived from non-medicinal parts of paris polyphylla and application of the extracellular vesicles in anti-inflammatory and whitening. According to the method, the extracellular vesicles are separated from stems, leaves and root hairs of non-medicinal parts of paris polyphylla by adopting double isoelectric precipitation combined with electrophoresis dialysis, and biological activity research is systematically performed on the extracellular vesicles sourced from the stems, leaves and root hairs. The cell and zebra fish model comprehensive evaluation proves that the extracellular vesicles from the two sources have obvious anti-inflammatory effects. However, in the melanin inhibition activity, the extracellular vesicles of the stems and leaves of the paris polyphylla are good in performance, and the inhibition effect of the extracellular vesicles on melanin generation in a zebra fish in-vivo model and the inhibition capacity of the extracellular vesicles on tyrosinase in vitro are obviously superior to those of a classic whitening agent arbutin. The limitation that only paris polyphylla tubers are utilized traditionally is broken through, development and efficacy verification of the paris polyphylla stem leaf and root hair extracellular vesicles are achieved for the first time, and the application prospect in the aspect of developing anti-inflammatory drugs and whitening cosmetics is wide.

The invention discloses an amylosucrase mutant and application thereof in synthesis of alpha-arbutin, and belongs to the technical field of genetic engineering. An amylosucrase mutant is obtained through an error-prone PCR technology, the mutant is obtained by mutation on an amylosucrase amino acid sequence derived from coprophilobacterium mediterranei, and the amino acid sequence of the amylosucrase mutant is shown as SEQ ID NO.4. The invention further discloses a preparation method of the amylosucrase mutant. The amylosucrase mutant can be used for synthesis and preparation of alpha-arbutin, the amylosucrase mutant is used as a biocatalyst to convert substrate hydroquinone to generate alpha-arbutin, and the reaction conversion rate of the reaction is proved to be high. Compared with a wild type enzyme, the amylosucrase mutant constructed by the invention has the advantages that the catalytic activity, the temperature stability and the substrate tolerance are obviously improved, the production cost is reduced, and the industrial application value of the amylosucrase is effectively improved.

This invention belongs to the field of biochemical technology, specifically disclosing a 6′- O A whole-cell biosynthesis method for caffeoyl arbutin and its analogues includes the following steps: using aromatic carboxylic acids and vinyl acetates as substrates, performing a transvinylation reaction under palladium catalyst and base conditions to prepare aromatic vinyl esters; using the prepared aromatic vinyl esters as acyl donors, ... β Arbutin, using acyl acceptors, undergoes an aromatic acylation reaction in an organic solvent with whole cells of Aspergillus oryzae as a catalyst to yield the 6′- O Caffeoyl arbutin or its analogues. This invention develops a two-step whole-cell catalytic method for the efficient and sustainable synthesis of CA and its analogues. The synthesized compounds exhibit potent inhibitory activity against mushroom tyrosinase. This invention pioneers a novel green biosynthetic pathway for tyrosinase inhibitors, demonstrating significant application potential in the food preservation and cosmetics industries.

The application discloses a preparation method of a normal-temperature preservation diluent for pig semen, and belongs to the technical field of biology.The main components of the normal-temperature preservation diluent are glucose, citric acid, sodium citrate, sodium bicarbonate, tris(hydroxymethyl)aminomethane, ethylenediaminetetraacetic acid disodium salt, penicillin G sodium salt, streptomycin sulfate, arbutin and double-distilled water.The diluent can maintain high activity of pig sperm in a short period, and the normal-temperature preservation time can reach about 10 days and meet the requirements of artificial insemination.The arbutin of the diluent has good anti-inflammatory and antioxidant protection effects, effectively improves the preservation activity and effect of pig sperm, and can be directly used for insemination after dilution or used for insemination after short-term preservation and short-distance transportation after dilution.The diluent improves the preservation quality of pig semen by using a low production cost and a simple operation method, is helpful to improve the utilization rate of excellent breeding stock, improve the reproduction rate, and is convenient for popularization and application.

1. Name of the designed product: Packaging bottle (WWP ARBUTIN BODY LOTION). 2. Use of the designed product: for packaging or transportation, bottle or similar container. 3. Design points of the designed product: in the perspective view. 4. Picture or photo that best indicates the design points: perspective view.