39 results about "Bakuchiol" patented technology

Personal care compositions containing an active selected from the group consisting of phlorogine, phlorgine BG, deoxyArbutin, sucrose dilaurate, bakuchiol, pyrenoine, millet, arlatone dioic acid, cinnamic acid, ferulic acid, achromaxyl, methyl nicotinamide, oil soluble licorice extract, folic acid, undecylenic acid, zinc undecylenate, L-tryptophan, thiamine HCl, hexylresorcinol, lipidami red vine, dragosine, methyl gentisate, inositol, symdiol 68, laminaine, their salts, their derivatives, their precursors, and / or combinations thereof. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

The present invention provides compositions of bakuchiol (UP246) having low levels of impurities, particularly furanocoumarin impurities. The present invention further provides improved methods for the isolation, purification and analysis of compositions of bakuchiol. Finally, the present invention provides methods for using the purified bakuchiol compositions and formulations thereof for the prevention and treatment of various diseases and conditions mediated by cyclooxygenase (COX), lipoxygenase (LOX), minor inflammatory conditions and various microbial infections. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.

The present invention discloses the application of bakuchiol compound in preparing medicine for treating psychogenic diseases and neurogenic diseases. Extracorporeal experiment and animal experiment show that the bakuchiol compound can suppressing dopamine transport protein, noradrenalin transport protein and 5-hydroxy tryptamine transport protein selectively, and no influence on gamma-aminobutyric acid transport protein and L-glytamic acid transport protein, no cytotoxicity, and antidepressant effect higher than available antidepressant medicine amfebutamoe hydrochloride. Therefore, the bakuchiol compound has excellent marketability in preparing medicine for treating psychogenic diseases and neurogenic diseases.

Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

The invention relates to malaytea scurfpea extract, a medical composition containing the malaytea scurfpea extract, a preparation method for the medical composition and application of the medical composition. The malaytea scurfpea extract comprises 40 to 90 percent of malaytea scurfpea phenol and 2 to 10 percent of malaytea scurfpea flavonoid compositions, and does not comprise psoralen and isopsoralen. As proved by experiments, the malaytea scurfpea extract and the medical composition containing the malaytea scurfpea extract have stronger comprehensive function on estrogen beta receptors, and have better synergistic effect, so that the malaytea scurfpea extract and the medical composition containing the malaytea scurfpea extract are predicted to be used for treating climacteric syndrome, breast carcinoma and / or cardiovascular and cerebrovascular diseases.

The invention discloses a method for preparing a natural medicinal effective component, which is characterized by comprising the following steps of: extracting fructus psoraleae with ethanol; precipitating the extract with water; purifying filtrate by a macroporous resin; extracting the filtrate with an organic solvent; abandoning the extract; and washing residues. Technical method comparison experiments prove that the content of the bakuchiol prepared by the method is over 90 percent, which sufficiently proves the advancement of the method.

Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

The present invention discloses a novel use of bakuchiol or an extract containing bakuchiol in preventing or treating a woman suffering osteoporosis. An embodiment of this novel use is a pharmaceutical composition containing bakuchiol or an extract containing bakuchiol, which can be in the dosage forms of topical use, oral administration, injection or sustained release. The present invention also discloses a novel use of bakuchiol or an extract containing bakuchiol in preventing or treating a woman suffering breast cancer.

The invention discloses a method for separating psoralen, isopsoralen and bakuchiol from fructus psoraleae. The method comprises the following steps: a) crushing fructus psoraleae; and extracting through petroleum ether to obtain a coarse petroleum ether extractive of fructus psoraleae; b) transferring the coarse petroleum ether extractive of fructus psoraleae to a polyamide column; performing gradient elution through a mixed solution of ethyl alcohol and water; collecting target current component; and performing pressure-reduced compressing to obtain bakuchiol and a mixture of psoralen and isopsoralen; and c) transferring the mixture of psoralen and isopsoralen to a silicagel column; eluting with a mixed solution of petroleum ether and ethyl acetate; collecting the target current component; and performing pressure-reduced concentration to obtain psoralen and isopsoralen. With the adoption of the method, psoralen, isopsoralen and bakuchiol can be synchronously massively separated, andthe purity is beyond 99%; the problem of synchronously separating psoralen, isopsoralen and bakuchiol can be solved.

The invention relates to a bakuchiol extractive, and a preparation method and application thereof. The preparation method comprises crushing psoralea corylifolia medicinal material, performing cold-dipping extraction by using petroleum ether, and recovering the solvent, so as to obtain the bakuchiol extractive; adding petroleum ether for dissolving, blending the sample with silica gel to obtain a loose mixture, completely volatizing the solvent, applying the sample to a silica gel column for column chromatography, eluting by using petroleum ether, performing TLC tracking, merging eluates containing bakuchiol, and recovering the solvent, so as to obtain a bakuchiol crude product; and further purifying the bakuchiol crude product, concretely, dissolving the crude product with petroleum ether, blending the sample with silica gel to obtain a loose mixture, completely volatilizing the solvent, applying the sample to a silica gel column for column chromatography, eluting by using petroleum ether and ethyl acetate, performing TLC tracking, merging eluates containing bakuchiol, and recovering the solvent, so as to obtain a bakuchiol purified product. The technology is simple to operate, low in cost and stable in yield, is capable of rapidly obtaining bakuchiol a in large scale, and is suitable for large-scale industrialized production demands.

The invention discloses a green process for extracting and purifying bakuchiol from fructus psoraleae, and belongs to the technical field of preparation of plant extracts. According to the process, the bakuchiol in the fructus psoraleae is extracted by adopting a carbon dioxide supercritical extraction technology, the bakuchiol with the purity of more than 98% is obtained by applying a column chromatography technology after primary separation of removing high-polarity insoluble substances by dissolving treatment of a low-polarity organic solvent, and the yield is more than 5.0%. The process is an efficient environment-friendly process, and a sample is high in yield and purity. The process is simple in process, safe, good in controllability, low in cost, short in production period and suitable for large-scale industrial production.

The invention discloses a natural medicament active ingredient and a preparation method thereof, which are characterized in that: the content of the corylifolinin is 90 to 97 percent; the corylifolinin contains two impurities; and the content of the impurity psoralen is 3 to 8 percent, and the content of the impurity bakuchiol is less than 1 percent. Preferably, the content of the psoralen is 95 to 97 percent; the content of the impurity psoralen is 3 to 4.5 percent, and the content of the impurity bakuchiol is less than 0.5 percent. More preferably, the content of the psoralen is 96 to 97 percent; the content of the impurity psoralen is 3 to 4 percent, and the content of the impurity bakuchiol is less than 0.1 percent. Pharmacological experiments prove that the natural medicament active ingredient has excellent function for treating male erectile dysfunction.

A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.

The present invention discloses a novel use of bakuchiol or an extract containing bakuchiol in preventing or treating a woman suffering breast cancer. An embodiment of this novel use is a pharmaceutical composition containing bakuchiol or an extract containing bakuchiol, which can be in the dosage forms of topical use, oral administration, injection or sustained release. The present invention also discloses a novel use of bakuchiol or an extract containing bakuchiol in preventing or treating a woman suffering osteoporosis.

The invention discloses an active ingredient of a natural medicament and a preparation method thereof. The active ingredient is characterized in that: the psoralen content is 90 to 97 percent; the active ingredient contains two impurities; and the impurity corylifolinin content is 3 to 8 percent, and the impurity bakuchiol content is less than 1 percent. Preferably, the psoralen content is 95 to 97 percent; the impurity corylifolinin content is 3 to 4.5 percent, and the impurity bakuchiol content is less than 0.5 percent. More preferably, the psoralen content is 96 to 97 percent; the impurity corylifolinin content is 3 to 4 percent, and the impurity bakuchiol content is less than 0.1 percent. Pharmacological experiments prove that the active ingredient has excellent effect of treating male erectile dysfunction.

The invention relates to a fructus psoraleae extract. The fructus psoraleae extract does not contain psoralen and isopsoralen, meanwhile the weight content of the psoralen is above 80%, and the yield of the extract is above 10%. The extract can remarkably increase the bone mineral density of a patient suffering from osteoporosis and promote the effects of normal skeletal development and calcification.

The invention discloses a medicinal preparation for treating prostatitis, and the active ingredient of a natural medicament and a preparation method thereof. The medicinal preparation is characterized by comprising 90 to 97 percent of psoralen, wherein the psoralen contains two impurities, namely 3 to 8 percent of corylifolinin and less than 1 percent of bakuchiol; preferably, the medicinal preparation comprises 95 to 97 percent of psoralen, and the psoralen contains 3 to 4.5 percent of corylifolinin and less than 0.5 percent of bakuchiol; and more preferably, the medicinal preparation comprises 96 to 97 percent of psoralen, and the psoralen contains 3 to 4 percent of corylifolinin and less than 0.1 percent of bakuchiol. Pharmacodynamic experiments prove that the active ingredient has good effect of treating male erectile disorder.

The invention relates to a traditional Chinese medicine composition for treating depression, which consists of 2-10 ginkgo biloba extracts and 2-20 psoraleae extracts in parts by weight. Ginkgo biloba extract is water or ethanol extract of ginkgo biloba, and psoraleae extract is water or ethanol extract. The Ginkgo biloba extract is a standard Ginkgo biloba extract or an extract of total ginkgo lactones. The said psoralen extract is psoralen extract or bakuchiol extract. The composition is aimed at each link of the onset of depression, exerts pharmacological effects on multiple targets, avoids the toxicity and side effects of chemical drugs, and is a therapeutic and preventive drug for depression with broad market prospects.

The invention relates to herbal compositions having standalone preparations of two phytochemicals, Bakuchiol and Boswellic acid as well as synergistic combinations of Bakuchiol with either Boswellia oil or boswellic acid or both. Bakuchiol in these compositions has assay by HPLC of greater than 50%, whereas boswellic acid is standardized to at least 20% of 3-o-Acetyl-11-keto-beta-boswellic acid. The compositions are either oral—for relief and remission of proliferative skin disorders or topical—for the treatment and management of pain. The invention further provides process of preparation of these compositions. The invention also relates to use of the compositions for treating pain or proliferative skin disorders and various dosage regimens.

The invention discloses a bactericidal composition containing pseudolaric acid, a small molecular phenolic compound and plant essential oil. The bactericidal composition comprises effective components of pseudolaric acid, thymol, carvacrol, eugenol, paeonol, bakuchiol, thyme essential oil, pogostemon cablin essential oil, clove essential oil, origanum vulgare essential oil, cinnamon essential oil and cinnamyl aldehyde. The mass part ratio of the pseudolaric acid to the small molecular phenolic compound to the plant essential oil is 1: 1, 1: 10, 1: 30, 1: 50 and 1: 100. The bactericidal composition disclosed by the invention can be used for preventing and treating rhizoctonia solani, sclerotinia sclerotiorum, botrytis cinerea, fusarium graminearum, magnaporthe oryzae and fusarium oxysporum of cotton; according to the invention, the application cost of the Pseudolaricin is reduced, the generation of drug resistance of diseases is expected to be delayed or overcome, the service life of the medicament is prolonged, and the green treatment of the diseases is facilitated.

The invention discloses a formula based on separation and extraction of bakuchiol and an industrial production method thereof. The method comprises the following steps: firstly, performing supercritical extraction on a raw medicinal material to prepare an oily substance, then stirring an oily sample, prepared according to a ratio of a column mass ratio to a sample of 13.3: 1, with an eluent according to a mass ratio of 1 / 3, uniformly loading the oily sample, and then allowing the oily sample to slowly flow into a dry surface of silica gel along a stirring rod; conducting pressing at a speed of 0.02 column volume per minute to infiltrate the silica gel surface, performing flushing with an eluent having a sample mass ratio of petroleum ether to ethyl acetate of 3:1, and repeatedly adjusting a flow rate according to a polarity principle to separate the sample; and finally, adding an antioxidant, adding 1.5-2.0% of a decolorizing substance according to the properties of the sample, conducting repeated decolorizing at 50 DEG C two times, and finally, conducting concentrating until no solvent smell exists to obtain a red transparent substance. According to the invention, a control technology in the pretreatment and posttreatment of samples and in an experiment process is optimized, and the purposes of reducing cost and greatly improving yield and purity can be achieved.

A composition for the treatment of acne includes hydrolyzed Psoralea Corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In a specific implementation, the composition is a water-based acne gel. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.

The invention relates to a method for preparing high-purity bakuchiol by high-speed countercurrent chromatography separation. The method comprises the following steps: soaking a fructus psoraleae medicinal material in an ethanol solution, and extracting to obtain a fructus psoraleae crude extract; fully shaking the solvent system, standing for phase splitting, and separately collecting an upper phase and a lower phase; dissolving the fructus psoraleae crude extract in the upper phase, separating by adopting high-speed counter-current chromatography to obtain a mixed solution of bakuchiol and a lower phase by taking the upper phase as a stationary phase and the lower phase as a mobile phase, and removing the lower phase to obtain bakuchiol. According to the method, the high-purity bakuchiol is separated and purified from the fructus psoraleae medicinal material by utilizing a high-speed counter-current chromatography technology for the first time, all reagents of a solvent system can be recycled, and a good environment-friendly function is achieved.

The present invention relates to a pharmaceutical composition for prevention and treatment of dental caries comprising a fluoride varnish and an antibacterial substance as active ingredients. The fluoride varnish composition comprising xanthorrhizol, bakuchiol, bavachalcone, isobavachromene or bavachromene according to the present invention exhibits significant antibacterial activities against the strain Streptococcus mutans (S. mutans), which causes dental caries. In particular, the composition exhibits remarkable antibacterial activities compared xanthorrhizol, bakuchiol, bavachalcone, isobavachromene, bavachromene or a fluoride varnish. Therefore, the fluoride varnish comprising xanthorrhizol, bakuchiol, bavachalcone, isobavachromene or bavachromene can be usefully used for prevention and treatment of dental caries.

The invention provides a method for extracting bakuchiol from spring elm roots and purifying bakuchiol and application of bakuchiol in cosmetics, and belongs to the technical field of cosmetics. Dry spring elm root plant materials are smashed and then extracted with ethyl alcohol, then vacuum concentration is conducted, extraction is conducted with n-butyl alcohol, the n-butyl alcohol part is collected and concentrated, and bakuchiol is obtained; the method comprises the following steps: carrying out silica gel column chromatography on n-butyl alcohol fraction residues, separating the n-butyl alcohol fraction residues into four sub-components I-IV, further purifying the sub-component IV on silica gel, collecting a chromatographic solution, and concentrating to obtain a finished product. By means of the method, high-purity bakuchiol can be obtained, the bakuchiol is excellent in anti-inflammatory effect, and the good anti-inflammatory effect is achieved when the bakuchiol is applied to cosmetics.

The invention provides an electrochemical detection method for bakuchiol, and particularly relates to a method for determining the content of bakuchiol by detecting and analyzing test liquid used for preparing a traditional Chinese medicinal material preparation or a Chinese patent medicine preparation by adopting an ER-GO / GCE modified electrode as a working electrode. A result shows that the ER-GO / GCE modified electrode has the good electrocatalytic activity on bakuchiol, is wide in linear range, high in current response speed, low in detection limit, high in sensitivity and interference resisting capacity and good in reproducibility and stability and is successfully applied to detection on the content of bakuchiol contained in fructus psoraleae from different production areas; a novel method for quickly and sensitively determining the content of bakuchiol contained in fructus psoraleae is successfully established.