36 results about "Bakuchiol" patented technology

The invention provides recombinant yeast for producing bakuchiol as well as a construction method and application of the recombinant yeast. Wherein the recombinant yeast is Yarrowia lipolytica containing isopentenyl transferase, and the recombinant yeast is a Yarrowia lipolytica containing isopentenyl transferase. Wherein a gene for coding the isopentenyl transferase is derived from Psoralea coryllifelia Linn (Psoralea coryllifelia Linn), and the isopentenyl transferase is used for coding the isopentenyl transferase. By utilizing the recombinant yeast provided by the invention, the bakuchiol with high yield can be efficiently and quickly prepared through a biosynthesis method, and a technical support is provided for subsequent industrialization of the bakuchiol.

The invention relates to a whitening and anti-aging composition suitable for sensitive skin and application of the whitening and anti-aging composition, and belongs to the technical field of cosmetics. The composition comprises bakuchiol, hydrolyzed royal jelly protein, a radix pseudostellariae extract and a golden camellia flower extract as active ingredients. The bakuchiol has the effects of resisting aging, resisting oxidation, resisting inflammation and the like; the hydrolyzed royal jelly protein can help to relieve skin discomfort, preserve moisture, enhance the skin barrier function and the like; the golden camellia flower extract has the effects of resisting light aging, whitening skin, fading spots, resisting inflammation and relieving allergy, and the radix pseudostellariae extract has the effects of resisting inflammation, resisting oxidation, resisting aging and the like. According to the composition disclosed by the invention, through reasonable blending of the components, synergistic interaction can be realized, the effects of resisting inflammation, whitening and delaying senescence are remarkably improved, and the composition contains natural components, is mild and non-irritant, is suitable for sensitive skin and can be applied to various cosmetics.

The invention belongs to the field of biosynthesis, and particularly relates to saccharomyces cerevisiae engineering bacteria for producing psoralen as well as a construction method and application of the saccharomyces cerevisiae engineering bacteria. The saccharomyces cerevisiae engineering bacteria comprise a yield increasing path of DMAPP, a synthetic path of naringenin, a synthetic path of daidzein and a synthetic path of psoralen; the yield increasing approach of the DMAPP is to express mvaE, mvaS, ERG12, ERG8, ERG19 and IDI1 on a saccharomyces cerevisiae strain WAT11, and to express mvaE, mvaS, ERG12, ERG8, ERG19 and IDI1 on a saccharomyces cerevisiae strain WAT11. The synthetic route of the naringenin is that PAL, 4CL, CHS and CHI are expressed in Saccharomyces cerevisiae with yield increased by dimethyl allyl pyrophosphoric acid; the synthetic route of daidzein is that CHR, IFS and HID are expressed in saccharomyces cerevisiae synthesized by naringenin; the synthetic route of the psoralen is that PT and OC are expressed in saccharomyces cerevisiae synthesized by daidzein.

A topical neurocosmetic composition comprising a first component including one or more of bakuchiol, allantoin, squalane, or Morinda citrifolia extract; a second component including one or more of hyaluronic acid, vitamin E, Zanthoxylum alatum fruit extract, Coriandrum sativum seed oil, Vitex agnus-castus extract, Helianthus annuus sprout extract, niacinamide, resveratrol, or an ascorbyl ester; and a cosmetically acceptable oil-in-water vehicle configured to deliver both lipophilic and hydrophilic actives through the skin to dermal neurons. The composition improves measurable skin parameters such as hydration and elasticity and supports psychophysiological comfort. Methods of manufacture and use are also described

This application relates to the field of skin care products. More specifically, it relates to a facial essential oil and a preparation method thereof. A facial essential oil, by mass percentage, at least includes the following raw materials: 0.001-0.03% Cardiospermum halicacabum flower / leaf / vine extract, 0.1-1% Citrus nobilis Lour. peel oil, 0.1-1% Boswellia carterii oil, 0.8-1.5% bakuchiol, and the base oil makes up the balance; the preparation method is: mixing various raw materials until uniform to obtain the facial essential oil. This application has the advantages of reducing the greasiness brought by the facial essential oil to people with oily skin, moisturizing and controlling oil, maintaining the water-oil balance, improving skin elasticity, and rapid absorption.

The invention discloses a formula of traditional Chinese medicine acne-removing cream and a production process thereof. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 5 to 9 parts of radix arnebiae seu lithospermi, 1 to 3 parts of radix angelicae sinensis, 1 to 2 parts of bakuchiol, 20 to 25 parts of linseed oil, 10 to 15 parts of beewax, 1 to 2 parts of rosa rugosa, 1 to 3 parts of radix et rhizoma rhei, 2 to 4 parts of cortex phellodendri, 3 to 5 parts of rhizoma atractylodis-pericarpium citri reticulatae powder, 1 to 2 parts of rhizoma arisaematis powder, 1 to 3 parts of vitamin E, 0.2 to 0.6 part of adenosine, 0.5 to 1 part of Ectoine, 0.1 to 0.3 part of Pinoline and 2 to 4 parts of purified water. Alkannin contained in the radix arnebiae seu lithospermi has strong antibacterial and anti-inflammatory capacities and does not generate the problem of drug resistance, so that the growth of acnes is inhibited from the source. Angelica polysaccharide can promote proliferation of keratinocytes, enhance the skin barrier function and effectively resist external stimulation. Different from common hormones, salicylic acid and other irritant components in traditional acne-removing products, the formula integrates the double effects of safe acne removal and long-acting skin care by means of natural power.

The present application relates to a kind of whitening anti-aging composition suitable for sensitive skin and its application, belong to the technical field of cosmetics.The composition includes Psoralea corylifolia phenol, hydrolyzed royal jelly protein, radix notoginseng extract and camellia sinensis var. assamica flower extract as active ingredient.Psoralea corylifolia phenol has the effects of anti-aging, antioxidant and anti-inflammatory, etc.;Hydrolyzed royal jelly protein can help to relieve skin discomfort, moisturizing, enhance skin barrier function, etc.;Camellia sinensis var. assamica flower extract has the effects of anti-photoaging, whitening and anti-inflammatory soothing, while radix notoginseng extract has the effects of anti-inflammatory, antioxidant and anti-aging, etc.The composition of the present application can synergistically enhance the effects of anti-inflammatory, whitening and anti-aging by reasonable allocation of the above components, and the composition contains natural components, is mild and non-irritating, suitable for sensitive skin, and can be applied to various cosmetics.

The present invention relates to a cosmetic composition and a quasi-drug composition containing bakuchiol, milk thistle fruit extract, and cinnamon fruit extract; a skin improvement method; and use thereof. The bakuchiol, milk thistle fruit extract, and cinnamon fruit extract of the present invention have excellent skin-improving effects and are therefore highly useful as cosmetic compositions and quasi-drug compositions for improving skin, which can be expected to be used in a variety of industrial applications, such as cosmetics and quasi-drugs.

The application belongs to the technical field of cosmetics, and particularly relates to a whitening and anti-aging composition containing psoralen and vitamin C and a preparation method thereof. The whitening and anti-aging composition provided by the application is composed of scutellaria baicalensis georgi extract, white pool flower seed oil, psoralen and vitamin C, has a rapid and efficient whitening and anti-aging effect, is mild and non-irritating, and can be used for preparing skin care products with whitening and anti-aging effects. In the preparation of the scutellaria baicalensis georgi extract, a deep eutectic solvent combined with a pulsed direct current field treatment is used, which has the advantages of low cost, high extraction efficiency, simple operation, non-toxicity, good biocompatibility, biodegradability and the like. The preparation method of the whitening and anti-aging composition provided by the application is simple and easy to operate, is beneficial to industrialized production and application, and has good market application value.

The application discloses a Pichia pastoris engineering bacterium for converting methanol to synthesize bakuchiol from scratch as well as construction and application of the bacterium. In different chromosomal neutral sites of the Pichia pastoris, a heterologous p-coumaric acid synthesis pathway is introduced, key genes of tyrosine and phenylalanine synthesis pathways of a heterologous shikimic acid pathway are knocked out, overexpressed or heterologously expressed, a high-yield p-coumaric acid strain is obtained, on the basis of the strain, a heterologous bakuchiol biosynthesis pathway is introduced, bakuchiol synthetase is overexpressed, key genes of a MVA pathway and genes of an exogenous acetyl coenzyme A supply pathway are endogenously overexpressed or heterologously expressed, after optimization of a methanol concentration and back complementation of a His4 gene of the strain, the yield of the bakuchiol is effectively increased to 91.2 mg / L, which is 59.8 times higher than that of an initial strain, and the yield of the bakuchiol in a 15L fermenter reaches 692.8 mg / L. The application has the characteristics of high conversion efficiency, low production cost, easy preparation, wide industrial application prospect and the like.

This invention belongs to the field of cosmetic technology, specifically relating to a firming, brightening, and soothing composition and its application. The firming, brightening, and soothing composition provided by this invention is a compound of *Palmaria rubra* bark extract, *Capsella bursa-pastoris* fruit extract, *Saururus chinensis* extract, and bakuchiol. These four ingredients synergistically promote the transdermal absorption of active ingredients, achieving firming, brightening, and soothing effects. Furthermore, this composition is gentle and non-irritating, and its preparation method is simple, making it feasible for industrialization. The composition provided by this invention has a wide range of applicability in skincare products. Its preparation method for serums is simple and easy to operate, and the prepared serums have firming, brightening, and soothing effects. Moreover, patch tests show that the serums are gentle and non-irritating, indicating that the composition of this invention has broad market application value in skincare products.

The present invention discloses a plant whitening sunscreen composition and its preparation method and application, and relates to the field of cosmetic technology. The present invention provides a plant whitening sunscreen composition, comprising the following components in parts by weight: 0.5-5 parts of a P / O / W composite carrier, 0.1-3 parts of bakuchiol, and 0.1-3 parts of a thyme extract. The present invention stabilizes two components, pterostilbene and verbascoside, in a P / O / W pickering multiple emulsion system to form a P / O / W composite carrier, which is mixed with bakuchiol and thyme extract in specific parts by weight. On the one hand, it can achieve safe and efficient whitening by repairing, inhibiting melanin production, inhibiting melanin transport, and promoting the synergistic enhancement of multiple pathways of melanin autophagy; on the other hand, it can achieve safe and efficient whitening and sun protection, achieve the effect of "external protection and internal whitening", and can synergistically strengthen the skin's defensive barrier and improve problems such as dull skin in sensitive skin.

To provide a cosmetic composition in which a change in odor after long-term storage, particularly long-term storage at high temperature, is improved.SOLUTION: A cosmetic composition comprises or consists of (A) a first oil and / or a second oil, (B) an oil-soluble chamomile extract, and (C) bakuchiol, where the first oil has a carbon-carbon double bond, the second oil is a hydrocarbon oil having a branched structure, and, when the first oil is not included and the second oil is included, a content of the second oil is 5.0 pts.mass or more relative to 100 pts.mass of an oil-phase component.SELECTED DRAWING: None

The invention provides an anti-wrinkle and anti-aging composition containing vermilion as well as a preparation method and application of the anti-wrinkle and anti-aging composition, and relates to the technical field of cosmetics. The anti-wrinkle and anti-aging composition is prepared from the following components in parts by weight: 0.5 to 2 parts of a water-soluble active component, 10 to 14 parts of an oil-soluble active component and 85 to 89 parts of a nano wrapping material, the water-soluble active ingredients are selected from at least two of carnosine, theanine and VC ethyl ether; the oil-soluble active ingredients are selected from at least three of millettiamide, quercus roei seed oil, bakuchiol, tocopheryl acetate and phytol; the nano wrapping material is selected from at least four of glycerol, 1, 3-propylene glycol, butanediol, water, caprylic / capric triglyceride, lecithin and hydrogenated lecithin; all the components interact with one another, so that the transdermal absorption effect is improved, and the long-acting wrinkle-removing and anti-aging effects are achieved; the anti-wrinkle and anti-aging composition is applied to preparation of cosmetics, and is friendly to sensitive skin and high in safety.

The invention discloses an insecticidal composition of a compound medicament for preventing and controlling bemisia tabaci, pea aphid and corn aphid, and belongs to the technical field of pesticides. The invention relates to a plant source compound huperzine A, apigenin and psoralen B, which are respectively compounded with five different emulsifiers to form the plant source compound huperzine A, apigenin and psoralen B, and the emulsifiers mainly comprise any one of sulfosuccinic acid-1, 4-dioctyl ester, fatty alcohol-polyoxyethylene ether, NP-10, Tween 20 and Tween 500. Huperzine A, apigenin, psoralen B and emulsifiers with different concentrations are compounded to obtain the insecticide composition, and the synergistic effect is achieved through the interaction of the emulsifiers and the compound. The compound pesticide is used for preventing and controlling horticultural crop pests such as bemisia tabaci and aphids, the usage amount of the pesticide can be reduced, pesticide residues on crops can be reduced, the preparation process is simple, raw materials are input, all raw materials are converted into finished products, no pollution is caused to the environment, and wide market prospects are achieved.

The invention discloses cactus essence oil with an anti-wrinkle effect and a preparation method of the cactus essence oil, and belongs to the technical field of skin care. Comprising the following raw materials: prickly pear seed oil, simmondsia chinensis seed oil, squalane, caprylic / capric triglyceride, bakuchiol, rosa damascena flower oil, sandalwood oil, frankincense oil, carrot seed oil, pelargonium graveolens oil, bisabolol, crithmum maritimum oil and tocopherol. According to the cactus essence oil with the anti-wrinkle effect and the preparation method of the cactus essence oil, the cactus seed oil is used as a core substrate, core components such as bakuchiol and crithmum maritimum oil are scientifically matched with soothing components such as bisabolol, and special preparation processes such as low-temperature premixing, step-by-step mixing, vacuum homogenization and light-shielding standing are combined, so that the cactus essence oil with the anti-wrinkle effect is obtained. The prepared cactus essence oil realizes multiple improvements of wrinkle resistance, stability maintenance, skin feeling and production practicability.

The invention belongs to the field of plant active matter extraction equipment, relates to a continuous extraction device for improving the yield of bakuchiol and application of the continuous extraction device, and aims to solve the problems of long retention time, low solid-liquid mass transfer efficiency and low product yield of an extraction process in an existing bakuchiol extraction technology. The device comprises a jet flow slurry state kettle, a rising type stirring and sinking type jet flow system integrated in the kettle, a circulating pump integrated outside the kettle and a heater, continuous feeding is achieved, and continuous discharging is achieved through a solid-liquid separator. The rising type stirring and sinking type jet flow system of the device realizes the effects of countercurrent mixing and turbulence enhancement in the kettle, fresh fed materials and circulating materials are fully and uniformly mixed, the solid-liquid mass transfer efficiency is greatly improved, the extraction time is shortened, and the extraction yield of bakuchiol is improved; and meanwhile, continuous feeding and continuous discharging are achieved, and the production efficiency of the device is greatly improved. Compared with the prior art, the product yield is increased by 10% or above, the production efficiency is improved by 50% or above, and the method has the advantages of being adjustable in production scale, high in yield, easy to operate, continuous, low in cost and the like.

The invention discloses an isopentenyl transferase and an application of the isopentenyl transferase in synthesis of bakuchiol. Specifically, recombinant saccharomyces cerevisiae for expressing the isopentenyl transferase is constructed, the isopentenyl transferase CcPT6 from fructus psoraleae is obtained through screening, the isopentenyl transferase CcPT6 can catalyze an isopentenylation reaction of a coumaric acid substrate to generate bakuchiol, and the activity of the isopentenyl transferase CcPT6 is higher than that of a reported sequence BAK36. The CcPT7 is obtained by truncating 54 amino acids at the N end of the CcPT6, the catalytic activity is improved by 74%, and the activity of the CcPT7 is higher than that of a reported BAK36 mutant. In addition, the invention also provides a recombinant saccharomyces cerevisiae and yarrowia lipolytica engineering strain for integrally expressing the isopentenyl transferase CcPT6 or CcPT7, so that the artificial biosynthesis of the bakuchiol is realized. The discovery of the isopentenyl transferase and the construction of the recombinant engineering strain have important meanings for promoting the biosynthesis of the bakuchiol.

The present disclosure relates to synthetic biology and, in particular, the bioproduction of bakuchiol, and engineered enzymes for producing the same.

The present invention relates to a composition with anti-aging efficacy and its application. The hydrolyzed Candida strain after activation culture is inoculated into a mixed oil of Alnus rhombifolia seed oil and the fermentation product of Candida apicola / glucose / methyl rapeseedate, and fermentation is carried out to obtain a preliminary fermentation product; the obtained preliminary fermentation product is centrifuged and filtered to obtain a composite fermentation product containing various metabolites. The composition with anti-aging efficacy includes the composite fermentation product, bakuchiol, and rice fermentation broth, and the weight ratio of the composite fermentation product, bakuchiol, and rice fermentation broth is 1-3:1-2:1-3. Compared with the prior art, the present invention can form a self-assembled reverse micelle system, reducing the harm of emulsifiers to the skin. The synergistic effect of the composite fermentation product, bakuchiol, and rice fermentation broth in the composition with anti-aging efficacy jointly exerts the anti-aging efficacy.

The application provides application of bakuchiol in preparation of a medicine for treating vitiligo and a system for treating vitiligo, and belongs to the technical field of medicines. The application provides application of bakuchiol in preparation of a medicine for treating vitiligo, and the application adopts flavonoid compound bakuchiol to prepare the medicine for treating vitiligo, has smaller toxicity, and has a good curative effect on vitiligo in combination with ultraviolet light (such as UVA).

The present invention discloses the application of psoralidin in inhibiting the growth of algae and an algicidal preparation, belonging to the technical field of ecological restoration of water environment. Through a large number of experiments, the inventor has screened a natural allelochemical, psoralidin, which has wide raw material sources, is environmentally friendly, easily degradable, does not produce secondary pollution, has good ecological safety, is green and environmentally friendly, has a good effect on inhibiting the growth of algae and has a broad-spectrum algicidal performance. The algae inhibited by psoralidin include Microcystis aeruginosa, Heterosigma akashiwo, Skeletonema costatum, Phaeocystis globosa and other algae; it can be applied to the water bodies with algal blooms in inland lakes and also to the water bodies with red tide algal blooms in the ocean, and can be applied to fresh water and marine water bodies, and has broad application prospects in the field of controlling harmful algae.

The application provides a recombinant yeast for producing bakuchiol, a construction method and application thereof. The recombinant yeast is Yarrowia lipolytica containing isopentenyl transferase, and a gene coding the isopentenyl transferase is derived from Psoralea corylifolia Linn. The recombinant yeast can be used to produce bakuchiol in a large yield through a biosynthetic method, and provides technical support for industrialization of the bakuchiol.

The invention belongs to the technical field of pesticides, and particularly relates to a bactericidal composition for preventing and treating scab of big-fruit hawthorn. The invention relates to a bactericidal composition for preventing and treating scab of big-fruit hawthorn. The bactericidal composition is prepared by compounding bakuchiol and orysastrobin or dimethomorph. When the bakuchiol and the orysastrobin or the dimethomorph are compounded, in the compounding mass ratio ranges of (1-25): (10-1) and (1-40): (20-1), the combined action types of the bakuchiol and the orysastrobin and the combined action types of the bakuchiol and the dimethomorph on the scab of the big-fruit hawthorn respectively show a synergistic effect.

A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia, containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.

The invention discloses an application of psoralen B in preparation of a medicine for treating helminthosis, an in-vitro effectiveness experiment result of psoralen B on an echinococcosis multilocularis protoscolex shows that the killing effect of maduramicin ammonium on the protoscolex has concentration dependence, the death rate of the protoscolex can reach 90.63% + / -0.96% after the maduramicin ammonium is treated for 6 h at the concentration of 50 mu M, and the death rate of the protoscolex can reach 90.63% + / -0.96% at the concentration of 100 mu M, and the death rate of the maduramicin ammonium can reach 90.63% + / -0.96% at the concentration of 100 mu M. The death rate of the original head section can directly reach 100%; meanwhile, in-vitro effectiveness experiment results of psoralen B on trichina at different development stages show that after the trichina is treated for 72 hours under the concentration of 50 mu M, 80 mu M and 100 mu M, the death rates of muscular larvae reach 89.44% + / -0.81%, 96.29% + / -1.30% and 96.68% + / -1.06% respectively; after 48 hours of treatment, the death rate of the adults is 100%, and the killing effect is remarkable. More importantly, the applicant verifies that IBC can directly destroy the epidermal structure and cell integrity of the insect body for the first time through observation by an optical microscope and an electron microscope, and the discovery provides intuitive morphological evidence for the anti-parasitic effect of IBC.

The present invention relates to a cosmetic composition and a pharmaceutical composition comprising bakuchiol, a silybum marianum fruit extract, and a myrobalan fruit extract; a skin improvement method; the bakuchiol, silybum marianum fruit extract, and myrobalan fruit extract of the present invention have an excellent skin improvement effect, and thus have high utilization rates in a skin improvement cosmetic composition and a drug composition, and uses thereof. Therefore, various industrial applications such as cosmetics and foreign medicines can be expected.

The invention belongs to the technical field of cosmetics, and provides a vegetable fat composition with moisturizing, anti-aging and repairing effects and application of the vegetable fat composition in skin care products, the vegetable fat composition is composed of an active component A and an active component B, and the mass ratio of the active component A to the active component B is (96-99): (1-4); wherein the active component A is prepared from the following components in parts by mass: 20 to 50 parts of wheat germ fermented oil, 15 to 30 parts of simmondsia chinensis seed oil, 5 to 25 parts of macadamia nut seed oil and 5 to 15 parts of squalane; the wheat germ fermented oil is fermented oil obtained by fermentation of bacillus subtilis, and the bacillus subtilis is bacillus subtilis Demeria Pulchra Ugel-01, and the wheat germ fermented oil is fermented oil obtained by fermentation of the bacillus subtilis. The active component B is prepared from bakuchiol and acetyl hexapeptide-8, and the mass ratio of the bakuchiol to the acetyl hexapeptide-8 is (100 to 300): 1. According to the invention, the compound composition with excellent moisturizing, anti-aging and repairing effects is prepared by using common and expensive vegetable fat as a main raw material, and the components are simple.

The application belongs to the field of biosynthesis and particularly relates to a Saccharomyces cerevisiae engineering bacterium for producing bakuchiol, a construction method and application thereof. The Saccharomyces cerevisiae engineering bacterium comprises a DMAPP production pathway, a naringenin synthesis pathway, a daidzein synthesis pathway and a bakuchiol synthesis pathway. The DMAPP production pathway is expressed by mvaE, mvaS, ERG12, ERG8, ERG19 and IDI1 in the Saccharomyces cerevisiae strain WAT11. The naringenin synthesis pathway is expressed by PAL, 4CL, CHS and CHI in the Saccharomyces cerevisiae strain with increased dimethylallyl pyrophosphate. The daidzein synthesis pathway is expressed by CHR, IFS and HID in the Saccharomyces cerevisiae strain with naringenin synthesis. The bakuchiol synthesis pathway is expressed by PT and OC in the Saccharomyces cerevisiae strain with daidzein synthesis.

The invention discloses a firming and anti-wrinkle composition as well as a preparation method and application thereof, and the firming and anti-wrinkle composition comprises the following components in parts by mass: 0.2-0.5 part of a growth factor accelerant, 1 part of a lindera glauca fruit extract and 0.02-0.08 part of salmon essence source DNA (deoxyribonucleic acid) sodium. The growth factor accelerant is selected from at least one of hydroxyl pinacolone retinoate, bakuchiol, a spanishneedles herb extract, asiaticoside, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The growth factor accelerant, the lindera glauca fruit extract and the salmon essence source DNA sodium cooperate to improve the problems of skin laxity and slowdown epidermal layer cell renewal caused by deep protein loss and wrinkle formation caused by decline of the stratum corneum moisturizing capacity, and the effects of tightening and resisting wrinkles are synergistically exerted in multiple aspects.