88 results about "Retinol" patented technology

Disclosed herein are compositions of matter suitable for use in foods, feeds, pharmaceuticals and cosmetic care products, the compositions of matter comprising a retinoid component and fermentation residues thereof. In embodiments, the retinoid component is present in a weight ratio relative to the fermentation residue of 4: 1 or greater, where the retinoid contains cis-isomer and trans-isomer, where the cis-isomer is present in an amount of less than 3% by weight relative to the entire isomer mixture. Preferably, the composition is bio-based. Also described are biotechnological methods for producing the compositions otherwise described, as well as additional methods for processing such compositions into more stable, more commercially acceptable forms. Finally, foods, feeds, pharmaceuticals, and cosmetic care products incorporating the compositions described herein are also disclosed.

The invention discloses a method for extracting retinol from yeast fermentation liquor. The method comprises the following steps: A, extracting the fermentation liquor to obtain an extraction phase; step B, concentrating the extract phase to obtain concentrated oil; step C, purifying concentrated oil; and optionally step D, concentrating the purified eluent.

An oral care composition with retinoid compound, amino acid, and / or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and / or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and / or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.

The present invention relates to a composition for improving wrinkles, which contains retinol and a retinol booster as active ingredients, and a method for providing information for selecting a customized retinol booster for improving wrinkles, which comprises a step of identifying the base of a polymorphic site of a genetic polymorphic marker having a significant association with the degree of skin wrinkles.

A retinol derivative or a salt thereof, as well as a preparation method therefor and the use thereof. The retinol derivative or the salt thereof retains the anti-aging effect of retinol and reduces the side effects skin irritation and allergy thereof. In addition, the retinol derivative or the salt thereof further has the effects of whitening, resisting light-induced injury, resisting inflammation, resisting oxidation, repairing and the like, and thus has good application prospects in the field of cosmetic raw materials.

The invention provides a whitening and anti-aging extracellular vesicle compound as well as a preparation method and application thereof. The extracellular vesicle compound comprises extracellular vesicles derived from mesenchymal stem cells and active ingredients loaded in the extracellular vesicles, the active component comprises any one or a combination of at least two of retinoic acid, arbutin, panthenol, nicotinamide, ectoine, vitamine, hyaluronic acid, vitamin C, resveratrol or retinol; the ratio of the extracellular vesicles to the active ingredients is (1-10) * 10 < 8 >: (0.01-1) mg. The skin-care active ingredients are entrapped in the extracellular vesicles derived from the mesenchymal stem cells, so that the delivery efficiency of the skin-care active ingredients can be remarkably improved, the direct irritation of free components to the skin can be reduced, the generation of matrix metalloproteinase-1 (MMP-1) and melanin can be effectively inhibited, the light aging process of the skin can be delayed, and the skin-care composition has excellent whitening and anti-aging effects.

Suggested is an active mixture, comprising or consisting of (a) retinol and / or at least one retinol compound (b) at least one physiological cooling agent, wherein component (a) is present in an amount from 35 to 200 wt.-percent calculated on the amount of component (b).

The invention discloses a retinol / saccharomycetes protein polypeptide copolymer as well as a preparation method and application thereof, and relates to the field of biology. The preparation adopting the yeast polypeptide to entrap the retinol is created, the yeast polypeptide is extracted from yeast autolysis supernatant, the yeast autolysis supernatant adopts animal-derived protein as a nitrogen source for fermentation, the content of the retinol entrapped by the yeast polypeptide is remarkably increased, and the preparation is remarkably superior to the retinol in the aspects of stability, mildness, efficacy and the like.

The invention discloses liquid medicine for treating scalds. The liquid medicine is prepared by adding 0.1 to 0.17 g of calcium hydroxide, 0.05 to 0.5 g of carbohydrate, 95 to 100g of fatty acid, 0.05 to 0.2 mg of retinol, 60 to 70mg of vitamin E, 5 to 12mg of calcium, 2 to 6mg of phosphorus, 1 to 1.5 mg of sodium, 1 to 5mg of magnesium, 2 to 3mg of iron, 0.1 to 0.2 mg of zinc, 0.01 to 0.1 mg of copper, 0.5 to 1mg of manganese, 2 to 5mg of sesamol and 1 to 6mg of sesamin into every 100g of water. According to the invention, calcium soap generated by reaction of fatty acid and calcium hydroxide is utilized to quickly form a layer of physical protection barrier on a scald wound surface, so that the purposes of isolating air, reducing pollution, relieving pain and limiting exudation can be achieved; through cooperation of vitamin E, sesamol and sesamin, oxidative stress and inflammatory response generated after burn can be resisted, tissues are protected, symptoms are relieved, and repair is promoted. The components of the traditional Chinese medicine have a synergistic effect, so that the traditional Chinese medicine can be used for effectively treating scalds and is short in treatment period; and after the ointment is used for treating the scald wound, no scar is left.

The present invention relates to a new formulation, which comprises a high amount of retinol, which has a defined mixture of cis and trans isomers, in a specific solvent and in the presence of mixed tocopherol.

Pharmaceutical or cosmetic composition comprising the following components: a) a dermatologically suitable carrier material, b) a first active substance, and c) a second active substance; wherein d) the first active substance comprises royal jelly; and e) the second active substance comprises retinol, a retinol analogue or a mixture thereof.

The invention discloses an external repairing anti-wrinkle composition. The external repairing anti-wrinkle composition comprises a first active component, a second active component, a third active component and a carrier, wherein the first active component comprises a corn germ extract and retinol; the second active component comprises a ligusticum wallichii extract, a pseudo-ginseng extract, a dogwood extract and a herba artemisiae scopariae extract; the third active component comprises a palmitoyl pentapeptide-4 and hyaluronic acid conjugate; the carrier is an oil phase, a water phase and / or an excipient. According to the invention, all the active ingredients are scientifically proportioned to realize synergistic interaction, and the skin care product can be prepared into essence, skin moistening oil, facial mask and other skin care products for external use, is safe and free of side effects, can slow down the deepening and diffusion of wrinkles to a certain extent, and helps the skin to recover elasticity and compactness.

Provided are a method of producing retinol, the method comprising the step of culturing a microorganism of the genus Yarrowia in a medium comprising a non-ionic surfactant; a method of increasing retinol production; a method of producing retinoids; a medium composition for a microorganism of the genus Yarrowia for producing retinol, the composition comprising a non-ionic surfactant; a composition for producing retinol, the composition comprising the microorganism or a culture thereof and a non-ionic surfactant.

An oil-in-water emulsion having an SPF of at least 25, comprising: (a) at least 0.01 wt.% of one or more types of retinol selected from the group consisting of retinol, retinaldehyde, retinoic acid, or a combination thereof; (b) one or more water soluble antioxidants; (c) one or more oil soluble antioxidants; (d) at least 10 wt.% of one or more oil soluble or oil dispersible sunscreen components. Methods of making the oil-in-water emulsions as well as uses and methods of use of the oil-in-water emulsions.

The invention discloses a water-light makeup pre-emulsion and a preparation method thereof. The water-light makeup pre-emulsion comprises nicotinamide, retinol, 3-o-ethyl ascorbic acid, moringa seed oil, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, a humectant, an emulsifier, a thickener, a preservative, a pH regulator and deionized water. Nicotinamide, retinol, 3-o-ethyl ascorbic acid and moringa seed oil are compounded, so that the nicotinamide is used for remarkably buffering the potential irritation of the retinol; 2, 3-o-ethyl ascorbic acid and retinol form day and night synergy for resisting oxidation and promoting collagen synthesis, moringa seed oil serves as a lipid carrier to pre-disperse and wrap retinol, a water sample is physically isolated, and the problem that retinol and vitamin C derivatives are difficult to coexist is solved; the final product is moist and light in texture, presents natural water and light sensation after being smeared, can effectively smooth the skin and enhance the fitting degree of subsequent base makeup, and is free of mud rubbing burden.

The invention discloses a cosmetic formula, and aims to provide an anti-wrinkle skin care composition which can improve the synergistic effect of the formula, can contain water-soluble GHK tripeptide and fat-soluble palmitoyl GHK tripeptide at the same time, and is compounded with retinol, and a preparation method of the anti-wrinkle skin care composition. According to the key points of the technical scheme, an oil phase, a water phase, an antioxidant and active substance phase and a final phase are combined, and a special preparation process is adopted, so that the problems that water-soluble GHK tripeptide, fat-soluble palmitoyl GHK tripeptide and unstable retinol coexist in the same formula and stably and efficiently play roles are effectively solved; the overall anti-wrinkle, firming and repairing synergistic effect of the formula is remarkably improved, the comprehensive anti-aging effect which is difficult to achieve through a single component or simple compounding is achieved, and the composition is suitable for the technical field of cosmetic formulas.

The invention provides an anti-aging fusion vesicle as well as a preparation method and application thereof. The fusion vesicle comprises a fusion product of extracellular vesicles derived from mesenchymal stem cells and lipidosome, the liposome comprises a carrier formed by assembling phospholipid, cholesterol and an amphiphilic polymer, a fat-soluble active matter loaded on a hydrophobic layer of the carrier and a water-soluble active matter loaded on a hydrophilic inner cavity of the carrier, the fat-soluble active matter comprises any one or a combination of at least two of retinoic acid, resveratrol or retinol; the water-soluble active matter comprises any one or a combination of at least two of arbutin, panthenol, nicotinamide, ectoine, glassine, hyaluronic acid or vitamin C. The fusion vesicle provided by the invention can significantly improve the delivery efficiency of active skin care components, reduce the direct irritation of free components to skin, effectively inhibit the expression quantity of matrix metalloproteinase-1 and delay the photoaging process of skin, and has an excellent anti-aging effect.

Skin care compositions and, e.g., skin care compositions containing retinol and salicylic acid are disclosed herein. In accordance with one aspect, provided is a skin care composition comprising: a retinoid; salicylic acid, and / or a salt thereof; from about 1.5 to about 17 wt.% of a silicone; from about 1 to about 8 wt.% of a vitamin B; from about 5 to about 40 wt.% of a fatty component; and water, wherein the skin care composition has a pH of about 4.75 to about 6.7 and all weight percentages are based on the total weight of the skin care composition.

This application relates to a Yarowia liporitica microorganism with enhanced SNQ2 protein activity and retinoid-producing ability, a method for producing retinoids using the same, a composition for retinoid production, its use in retinoid production, and a method for producing the said microorganism.

The pharmaceutical or cosmetic composition comprises the following components: a) a dermatologically acceptable carrier substance, b) a first active substance, and c) a second active substance; wherein d) the first active substance comprises royal jelly; and e) the second active substance comprises retinol, retinol analogs or mixtures thereof.

The application discloses a method for simultaneously detecting retinoids and lipid-soluble vitamin metabolic marker groups in biological samples and matching reagents. The application is based on magnetic bead solid-phase extraction technology, significantly improves sample purification effect, and reduces matrix interference; in combination with a high-aqueous-phase reversed-phase chromatography system and a positive-negative ion switching multi-reaction monitoring mode, simultaneous separation and detection of seven retinoid molecules and a full spectrum of lipid-soluble vitamins are realized. The method has high sensitivity, strong specificity and wide detection range, and for the first time realizes one-stop analysis across species and sample types, thereby providing reliable platform support for clinical and scientific research applications.

The present invention discloses an externally applied repair and anti-wrinkle composition, which comprises a first active ingredient, a second active ingredient, a third active ingredient and a carrier: the first active ingredient comprises corn germ extract and retinol; the second active ingredient comprises chuanxiong extract, panax notoginseng extract, cornel extract and artemisia capillaris extract; the third active ingredient comprises a palmitoyl pentapeptide-4 and hyaluronic acid conjugate; and the carrier is an oil phase, an aqueous phase and / or an excipient. The present invention can achieve synergistic effects by scientifically proportioning each active ingredient, and can be prepared into skin care products such as essence, skin care oil, facial mask, etc. for external use, which is safe and has no side effects, and can, to a certain extent, slow down the deepening and spreading of wrinkles and help the skin restore elasticity and firmness.

The present application relates to a method for producing retinol comprising a step of culturing a Yarrowia microorganism in a medium containing an antioxidant, a method for increasing retinol production, a method for producing a retinoid, a medium composition for a Yarrowia microorganism for producing retinol containing an antioxidant, and a composition for producing retinol comprising the microorganism or a culture thereof and an antioxidant.

The invention discloses a preparation composition for preventing and treating eye diseases and delaying visual decline and a preparation method thereof. The composition is prepared from fructus lycii, semen cassiae, blueberries, marigold, eyebright, ligusticum wallichii, pseudo-ginseng, roxburgh rose, pleurotus citrinopileatus, bilberry, haematococcus pluvialis, xanthophyll, zeaxanthin, retinol, ergothioneine, beta-carotene, vitamin E, organic selenium, phospholipid DHA, procyanidine, curcumin and lycopene. The composition can prevent and treat eye diseases and delay visual decline. The traditional Chinese medicine composition can relieve asthenopia, can relieve the symptoms of blurred vision, dry eyes, soreness and swelling, pain and the like, and can treat macular degeneration. The composition has no side effect on a human body and is high in safety; injection administration and operation are avoided, no sequelae are left, and the medicine is convenient to take and carry by a patient; the preparation process is simple, the performance is stable and reliable, the production efficiency is high, the cost is low, and the application prospect is wide. The invention further discloses a polypeptide for relieving asthenopia, wherein the sequence of the polypeptide is shown as SEQ ID NO: 1.

Disclosed herein are compositions suitable for use in food, feed, pharmaceutical, and cosmetic products, comprising a retinoid component and its fermentation residue. In one embodiment, the retinoid component is present in a weight ratio to the fermentation residue of 4:1 or greater, the retinoid contains cis- and trans-isomers, and the cis-isomer is present in an amount of less than 3% by weight of the total isomer mixture. Preferably, the composition is biobased. Biotechnology methods for producing the compositions described elsewhere are also described, as well as additional methods for processing such compositions into more stabilized, more commercially acceptable forms. Finally, food, feed, pharmaceutical, and cosmetic products incorporating the compositions described herein are also disclosed.

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-aging emulsion for relieving irritation of retinol as well as a preparation method and application of the anti-aging emulsion. Specifically, the anti-aging emulsion is prepared by taking the Lichen extract, sodium hyaluronate (400Da-3KDa), sodium hyaluronate (1W-3W Da), polyamide-8 (and) pentaerythritol tetra (bis-tert-butylhydroxyhydrocinnamate) ester and retinol as main components, and tests prove that the prepared anti-aging emulsion has remarkable effects of repairing barrier damage and improving skin hydration, and has a good anti-aging effect. Meanwhile, the anti-aging effect of the retinol is not affected, the composition can be used for relieving the irritation problem of the retinol, the color change problem of the retinol can be obviously solved by organically combining the retinol and the raw materials, and therefore the composition has good practical application value.

The present invention relates to an anti-wrinkle cosmetic complex comprising Inga edulis and a retinol derivative useful in reducing the signs of aging in the eye area. The present invention also relates to a cosmetic composition comprising the aforementioned complex, as well as to uses thereof and a method for cosmetic treatment.

The invention discloses an active ingredient dissolving composition. The active ingredient dissolving composition comprises a component (a), a component (b) and a component (c), the component (a) comprises at least one long-chain fatty acyl acidic amino-acid ester; the component (b) comprises at least one polyol; the component (c) comprises at least one active matter and is selected from one or more of glycyrrhetinic acid, stearyl glycyrrhizinate, curcumin, tetrahydrocurcumin, resveratrol, glabridin, retinol and ceramide. The composition disclosed by the invention is very stable and good in safety.

The present invention addresses the problem of providing a novel topical skin preparation. The present invention provides a topical skin preparation or the like containing glycylglycine and retinol acetate.

The present application relates to: a Yarrowia genus microorganism having a retinol-producing ability, in which the activity of an ABC3 protein is reduced as compared to the endogenous activity thereof; a retinol production method using the same; a method for producing a microorganism of the genus Yarrowia having a retinol-producing ability; the invention discloses a method for enhancing retinol release of microorganisms. And a composition for producing retinol.