Anti-wrinkle skin care composition and preparation method thereof

Abstract

The invention discloses a cosmetic formula, and aims to provide an anti-wrinkle skin care composition which can improve the synergistic effect of the formula, can contain water-soluble GHK tripeptide and fat-soluble palmitoyl GHK tripeptide at the same time, and is compounded with retinol, and a preparation method of the anti-wrinkle skin care composition. According to the key points of the technical scheme, an oil phase, a water phase, an antioxidant and active substance phase and a final phase are combined, and a special preparation process is adopted, so that the problems that water-soluble GHK tripeptide, fat-soluble palmitoyl GHK tripeptide and unstable retinol coexist in the same formula and stably and efficiently play roles are effectively solved; the overall anti-wrinkle, firming and repairing synergistic effect of the formula is remarkably improved, the comprehensive anti-aging effect which is difficult to achieve through a single component or simple compounding is achieved, and the composition is suitable for the technical field of cosmetic formulas.

Description

TECHNICAL FIELD

[0001] The present application relates to a cosmetic formulation, more particularly, it relates to an anti-wrinkle skin care composition and a preparation method thereof. BACKGROUND

[0002] Skin aging is a complex and multi-factorial biological process, with age, the synthesis of collagen and elastin in the skin decreases, cell renewal slows down, and the structure of the dermis deteriorates, resulting in external signs of aging such as fine lines, dry lines, sagging, and dullness.

[0003] The functional ingredients commonly used in anti-aging skin care products at present mainly include: (1) Retinoids, which can effectively improve skin texture and fine lines by stimulating dermal collagen synthesis, promoting cell renewal, and improving sebum secretion; (2) Signal peptides, such as GHK tripeptide (Gly-His-Lys), which can promote fibroblast proliferation and collagen synthesis; (3) Antioxidants, which can inhibit cell damage caused by free radicals.

[0004] GHK tripeptide is a natural small molecule peptide that can effectively activate skin repair signals, improve wound healing, and delay skin aging. However, it has strong water solubility, limited skin penetration ability, and insufficient stability in emulsion systems.

[0005] Palmitoyl-GHK tripeptide is modified by palmitoyl group to enhance its liposolubility and skin penetration, and has good biological stability and sustained release effect. It is widely used in cosmetic formulations to enhance deep action and efficacy persistence.

[0006] Retinol is a derivative of vitamin A and is one of the anti-aging ingredients commonly recommended by dermatologists. It can regulate gene expression, increase cell metabolic rate, and increase dermal collagen production. However, it is easily oxidized and degraded in formulations, and high concentrations may cause skin redness or irritation, so the amount needs to be reasonably controlled and combined with soothing or repair ingredients. SUMMARY

[0007] In view of the deficiencies of the prior art, the purpose of the present application is to provide an anti-wrinkle skin care composition and a preparation method thereof, which can improve the synergistic effect of the formulation, contain water-soluble GHK tripeptide and liposoluble palmitoyl-GHK tripeptide, and compound retinol.

[0008] To achieve the above object, the present application provides the following technical scheme: an anti-wrinkle skin care composition, comprising an oil phase component, an aqueous phase component, an active antioxidant component and a final phase component, the oil phase component comprising 8-12% glycerol monostearate, 5-7% cetyl alcohol, 5-7% heavy liquid paraffin, 0.5-0.8% Tween 60, 0.1-0.2% methyl p-hydroxybenzoate and 0.05-0.07% propyl p-hydroxybenzoate;

[0009] The aqueous phase component comprises 5-7% 70% sorbitol, 2-3% glycerol, 2-3% propylene glycol, 0.03-0.07% disodium ethylenediaminetetraacetate, 0.02-0.04% citric acid monohydrate, 0.02-0.04% sodium citrate and water;

[0010] The antioxidant and active substance phase comprises 5-6% anhydrous lanolin, 2-3% glycerol, 2-3% propylene glycol, 0.006-0.009% butylated hydroxyanisole, 0.002-0.004% dibutylated hydroxytoluene, 0.01-0.04% retinol and 0.01-0.05% palmitoyl tripeptide;

[0011] The final phase component comprises 1.5-4.0% dimethicone, 0.01-0.05% GHK tripeptide, essence and water.

[0012] The present application further provides that the weight percentage of water in the aqueous phase component and the final phase component is set to 100% based on the weight percentage of the remaining raw materials.

[0013] The present application further provides that the lanolin can be replaced by bleached lanolin, and the heavy liquid paraffin can be replaced by virgin olive oil.

[0014] The present application further provides a preparation method of the anti-wrinkle skin care composition, comprising the following steps: S1, configuring each component: mixing based on the weight percentage of each material to form the oil phase component, the aqueous phase component, the antioxidant and active substance phase and the final phase component;

[0015] S2, aqueous phase component treatment: heating the aqueous phase component to 75°C and continuously stirring;

[0016] S3, adding the oil phase component: after the heating of the aqueous phase component is completed, the oil phase component is added to the aqueous phase component, and stirring is continuously performed during the addition of the oil phase component and the temperature is maintained at 70-75°C, and the stirring time is set to 20 min;

[0017] S4, adding antioxidant and active substance phase: after the completion of stirring, the mixture of step S3 is cooled to 60℃, after the completion of cooling, the antioxidant and active substance phase is added;

[0018] S5, adding final phase component: continue to cool the mixture formed in step S4, the cooling temperature is 40℃, after the completion of cooling, the final phase component is added;

[0019] S6, viscosity adjustment: continue to stir the mixture formed in step S5, the stirring time is 25min, after the completion of stirring, water is added to the mixture based on the volume and viscosity parameters of the required final product, and the required final product is formed.

[0020] By adopting the above technical scheme, the beneficial effects are: 1. The application combines the oil phase, the water phase, the active phase antioxidant and the final phase, and through a special preparation process, the problem of coexistence, stability and high efficiency of water-soluble GHK tripeptide, fat-soluble palmitoyl GHK tripeptide and unstable retinol in the same formula is effectively solved. Specifically, GHK tripeptide activates the epidermal repair pathway as a short-acting and rapid repair component, palmitoyl GHK tripeptide provides sustained release and deep dermal layer support, and retinol promotes cell renewal, enhances keratin metabolism and stimulates collagen synthesis, thereby synergistically acting on multiple skin layers to resist external aging signs. In addition, in order to ensure the stability and skin tolerance of retinol in the emulsion base, the application introduces an appropriate amount of antioxidant (such as BHT, BHA) in the emulsion system, and avoids thermal degradation of active components through temperature control process, thereby realizing a mild, stable and efficient polypeptide A anti-wrinkle composition. The above composition contains double GHK peptides acting on different skin layers, successfully compounding the powerful anti-wrinkle ingredient retinol, and the above active ingredients can effectively maintain biological activity and synergistically act with the aid of propylene glycol and glycerol, thereby resisting wrinkles from multiple targets such as promoting collagen synthesis, inhibiting matrix metalloproteinase activity and stimulating cell renewal, significantly improving the overall anti-wrinkle, firming and repair synergistic effect of the formula, and achieving comprehensive anti-aging effect that cannot be achieved by single component or simple compounding.

[0021] 2. Further, the application sets a carrier system capable of simultaneously loading water-soluble GHK tripeptide and fat-soluble palmitoyl GHK tripeptide, the water-soluble GHK tripeptide is arranged in the final phase, the fat-soluble palmitoyl tripeptide is arranged in the active phase antioxidant and dissolved in anhydrous lanolin, thereby effectively avoiding the compatibility problem caused by the difference in solubility, and through temperature control at different stages, the activity of the tripeptide is maximally protected to prevent degradation and inactivation. At the same time, the glycerol, propylene glycol and sorbitol in the formula serve as humectants, which significantly improve the permeability of the two GHK peptides together with Tween 60, glycerol monostearate and dimethicone.

[0022] 3、Meanwhile, for retinol, the present application sets retinol in the antioxidant component, which effectively isolates the threat of moisture to the stability of retinol by using anhydrous lanolin as the main solvent and a wrapping matrix, anhydrous environment, significantly delays the oxidative decomposition of retinol, protects its activity during storage and use, and avoids the destruction of retinol at high temperatures by adding the antioxidant and active substance phase containing retinol at 60°C during preparation. The above-mentioned scheme not only greatly improves the chemical stability of retinol, prolongs the effective period and efficacy persistence of the product, but also helps to release retinol by wrapping with lanolin, to a certain extent, reduces the irritation that may be caused by direct contact with the skin, and improves the mildness and user tolerance of the formula.

[0023] 4、And, the preparation method of the present application controls the temperature and adds it in stages to ensure the activity and stability of each phase. First, the water phase component is heated to 75°C to ensure dissolution and sterilization of the material, and the oil phase is added while maintaining the appropriate emulsification temperature, and the emulsion system is fully stirred to form a uniform emulsion system. By cooling the emulsion system to 60°C and then adding heat-sensitive active substances, the damage to the ingredients caused by high temperature is avoided. After cooling to 40°C, another group of heat-sensitive active substances is added, further protecting the activity of GHK tripeptide and preventing the volatilization of the fragrance. Finally, the activity is ensured to be uniform by continuous stirring, and the viscosity of the final product is adjusted according to the needs to ensure good use and stability, and the effectiveness of all active ingredients (especially easily degradable peptides and retinol) is maximized, while the physical and chemical stability of the entire composition system is ensured. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 Preparation method flow chart for the anti-wrinkle skin care composition and its preparation method embodiment of the present application; DETAILED DESCRIPTION

[0025] REFERENCE Figure 1 Further explanation of the anti-wrinkle skin care composition and its preparation method embodiment of the present application.

[0026] For ease of explanation, spatial relative terms such as "upper", "lower", "left", "right" and the like are used in the embodiments to describe the relationship of one element or feature to another element or feature as shown in the drawings. It should be understood that, in addition to the orientation shown in the drawings, the spatial terms are intended to include different orientations of the device in use or operation. For example, if the device in the drawing is inverted, the element described as being "below" other elements or features will be positioned "above" the other elements or features. Therefore, the exemplary term "below" can include both upward and downward orientations. The spatial relative description used herein can be interpreted accordingly if the device is positioned in other ways (rotated 90 degrees or positioned in other orientations).

[0027] Moreover, the terms such as "first" and "second" and the like are merely used to distinguish one component from another component having the same name, and do not necessarily require or imply there is any such actual relationship or order between the components.

[0028] An anti-wrinkle skin care composition, comprising an oil phase component, an aqueous phase component, an antioxidant and active substance phase, and a final phase component, the oil phase component comprising 8-12% glycerin monostearate, 5-7% cetyl alcohol, 5-7% heavy liquid paraffin, 0.5-0.8% Tween 60, 0.1-0.2% methyl p-hydroxybenzoate, and 0.05-0.07% propyl p-hydroxybenzoate;

[0029] The aqueous phase component comprises 5-7% 70% sorbitol, 2-3% glycerin, 2-3% propylene glycol, 0.03-0.07% disodium ethylenediaminetetraacetate, 0.02-0.04% citric acid monohydrate, 0.02-0.04% sodium citrate, and water;

[0030] The antioxidant and active substance phase comprises 5-6% anhydrous lanolin, 2-3% glycerin, 2-3% propylene glycol, 0.006-0.009% butylated hydroxyanisole, 0.002-0.004% dibutylated hydroxytoluene, 0.01-0.04% retinol, and 0.01-0.05% palmitoyl tripeptide;

[0031] The final phase component comprises 1.5-4.0% dimethicone, 0.01-0.05% GHK tripeptide, fragrance, and water.

[0032] The weight percentage of water in the aqueous phase component and the final phase component is set to make up water to 100% based on the weight percentage of the remaining raw materials.

[0033] The lanolin can be replaced by bleached lanolin, and the heavy liquid paraffin can be replaced by virgin olive oil.

[0034] The application also provides a preparation method of an anti-wrinkle skin care composition, comprising the following steps: S1, configuring each component: mixing based on the weight percentage of each material to form an oil phase component, an aqueous phase component, an antioxidant and active substance phase, and a final phase component;

[0035] S2, aqueous phase component treatment: heating the aqueous phase component to 75°C and continuously stirring;

[0036] S3, adding oil phase components: after the water phase component is heated, the oil phase component is added into the water phase component, the stirring is continuously carried out and the temperature is set to 70-75°C during the addition of the oil phase component, and the stirring time is set to 20 min;

[0037] S4, adding antioxidant and active substance phase: after the stirring is completed, the mixture of step S3 is cooled to 60°C, and after the cooling is completed, the antioxidant and active substance phase is added;

[0038] S5, adding final phase component: the mixture formed in step S4 is continuously cooled to 40°C, and after the cooling is completed, the final phase component is added;

[0039] S6, viscosity adjustment: the mixture formed in step S5 is continuously stirred for 25 min, and after the stirring is completed, water is added into the mixture based on the volume and viscosity parameters of the required final product to form the required final product.

[0040] The present application combines the oil phase, the water phase, the active phase antioxidant and the final phase, and effectively solves the problem that the water-soluble GHK tripeptide, the fat-soluble palmitoyl GHK tripeptide and the unstable retinol coexist in the same formula, are stable and efficiently play a role. Specifically, the GHK tripeptide activates the epidermal repair pathway as a short-acting and rapid repair component, the palmitoyl GHK tripeptide provides persistent release and deep dermal layer support, and the retinol promotes cell renewal, enhances keratin metabolism and stimulates collagen synthesis, thereby synergistically acting on multiple skin layers to resist external signs of aging. In addition, in order to ensure the stability and skin tolerance of retinol in the emulsion base, the present application introduces an appropriate amount of antioxidant (such as BHT, BHA) in the emulsion system, and avoids thermal degradation of active components through temperature control process, thereby realizing a mild, stable and efficient polypeptide A anti-wrinkle composition. The above composition contains double GHK peptides acting on different skin layers and successfully compounding strong anti-wrinkle ingredient retinol. The above active ingredients can effectively maintain biological activity after being added, and synergistically act with the aid of propylene glycol and glycerol, from promoting collagen synthesis, inhibiting matrix metalloproteinase activity, stimulating cell renewal and other multi-targets to jointly resist wrinkles, significantly improving the overall anti-wrinkle, tightening and repair synergistic effect of the formula, and realizing the comprehensive anti-aging effect that cannot be achieved by single component or simple compounding.

[0041] Further, the present application sets up a carrier system capable of simultaneously loading water-soluble GHK tripeptide and fat-soluble palmitoyl GHK tripeptide, sets up water-soluble GHK tripeptide in the final phase, sets up fat-soluble palmitoyl tripeptide in the active phase antioxidant and dissolves in anhydrous lanolin, effectively avoids the compatibility problem caused by the difference in solubility, protects the tripeptide activity to the maximum extent through temperature control in different stages, prevents degradation and inactivation, at the same time, glycerol, propylene glycol and sorbitol in the formula serve as humectants, at the same time with Tween 60, glycerol monostearate and dimethicone, significantly improves the permeability of the two GHK peptides.

[0042] At the same time, for retinol, the present application sets up retinol in the antioxidant component, which uses anhydrous lanolin as the main solvent and the wrapping matrix, effectively isolates the threat of water to the stability of retinol in the anhydrous environment, significantly delays the oxidative decomposition of retinol, guarantees the activity of retinol in the storage and use process, adds the antioxidant and active substance phase containing retinol at 60℃ in the preparation process, avoids the damage of high temperature to retinol, the above-mentioned scheme not only greatly improves the chemical stability of retinol, prolongs the product shelf life and efficacy persistence, but also helps to release retinol through the wrapping effect of lanolin, to a certain extent, reduces the irritation caused by the direct contact of retinol with the skin, and improves the mildness and user tolerance of the formula.

[0043] Moreover, the preparation method of the present application controls the temperature and adds the components in stages to ensure the activity and stability of each phase. First, the water phase components are heated to 75℃ to ensure dissolution and sterilization, and the oil phase is added while maintaining the appropriate emulsification temperature, and the emulsion system is fully stirred to form a uniform emulsion system. The emulsion system is cooled to 60℃, and then the heat-sensitive active substances are added to avoid damage to the components caused by high temperature. Another group of heat-sensitive active substances is added after cooling to 40℃, further protecting the activity of GHK tripeptide and preventing the volatilization of fragrances. Finally, continuous stirring is used to ensure uniform activity, and water is added as needed to adjust the viscosity of the final product, ensuring good use and stability, and maximizing the effectiveness of all active ingredients, especially easily degradable peptides and retinol, while ensuring the physical and chemical stability of the entire composition system.

[0044] For example, the following scheme is used to prepare a skin care cream: A component (oil phase): - glycerol monostearate 10% - cetyl alcohol 6% - liquid paraffin 6% - Tween 60 0.6% - methyl paraben 0.2% - propyl paraben 0.1%

[0045] B component (water phase): - 70% sorbitol solution 6% - glycerol 3% - propylene glycol 3% - sodium citrate 0.04% - citric acid monohydrate 0.04% - disodium ethylenediaminetetraacetate 0.05% - water 42%

[0046] C component (active + antioxidant phase): - lanolin 6% - glycerin 2% - propylene glycol 2% - BHT 0.003% - BHA 0.008% - retinol 0.025% - palmitoyl GHK tripeptide 0.02%

[0047] D component (final phase): - dimethicone 2% - fragrance 0.1% - GHK tripeptide 0.02% - water (make up to 100%)

[0048] The composition is prepared in the following steps: 1) heat the oil phase (A component) to 70-75°C; 2) heat the water phase (B component) to 75°C, slowly add the oil phase to the water phase under stirring to form an emulsion system; 3) cool to 60°C, add the active phase C component, continue stirring; 4) continue to cool to 40°C, add D component, finally make up the water amount to adjust the viscosity.

[0049] wherein,

[0050] (BHA) is butylated hydroxyanisole;

[0051] (BHT) is butylated hydroxytoluene

[0052] The above merely describes the preferred embodiments of the present application and is not intended to limit the present application. Any change or replacement within the technical scheme of the present application made by those skilled in the art shall fall within the protection scope of the present application.

Claims

1. An anti-wrinkle skincare composition, characterized in that, It includes an oil phase component, an aqueous phase component, an antioxidant and active substance phase, and a final phase component. The oil phase component includes 8%–12% glyceryl monostearate, 5%–7% cetyl alcohol, 5%–7% heavy liquid paraffin, 0.5%–0.8% Tween 60, 0.1%–0.2% methylparaben, and 0.05%–0.07% propylparaben. The aqueous phase component comprises 5%–7% 70% sorbitol, 2%–3% glycerol, 2%–3% propylene glycol, 0.03%–0.07% disodium ethylenediaminetetraacetate, 0.02%–0.04% citric acid monohydrate, 0.02%–0.04% sodium citrate, and water; The antioxidant and active ingredient phase comprises 5%–6% anhydrous lanolin, 2%–3% glycerol, 2%–3% propylene glycol, 0.006%–0.009% butylated hydroxyanisole, 0.002%–0.004% butylated hydroxytoluene, 0.01%–0.04% retinol, and 0.01%–0.05% palmitoyl tripeptide; The final phase composition includes 1.5%-4.0% dimethicone, 0.01%-0.05% GHK tripeptide, fragrance, and water.

2. The anti-wrinkle skincare composition according to claim 1, characterized in that, The weight percentage of water in the aqueous phase component and the final phase component is set as follows: based on the weight percentage of the remaining raw materials, water is added to bring the total to 100%.

3. The anti-wrinkle skincare composition according to claim 1, characterized in that, The lanolin can be replaced with bleached lanolin, and the heavy liquid paraffin can be replaced with extra virgin olive oil.

4. A method for preparing an anti-wrinkle skincare composition applicable to any one of claims 1-3, characterized in that, Includes the following steps: S1. Configuring each component: Mixing based on the weight percentage of each material to form an oil phase component, an oil phase component, an antioxidant and active substance phase, and a final phase component; S2. Aqueous phase component treatment: Heat the aqueous phase component to 75°C and stir continuously; S3. Add oil phase component: After the aqueous phase component is heated, add oil phase component to the aqueous phase component. During the process of adding oil phase component, continue stirring and keep the temperature between 70-75℃. The stirring time is set to 20min. S4. Adding antioxidant and active substance phase: After stirring, cool the mixture from step S3 to 60°C. After cooling, add the antioxidant and active substance phase. S5. Add the final phase component: Continue to cool the mixture formed in step S4 to 40°C. After cooling is complete, add the final phase component. S6. Viscosity Adjustment: Continue stirring the mixture formed in step S5 for 25 minutes. After stirring, add water to the mixture based on the required volume and viscosity parameters of the final product to form the desired final product.

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