94 results about "Polysorbate" patented technology

The invention discloses a diluent for whole blood lateral immunochromatography detection as well as a preparation method and a detection method thereof, and belongs to the technical field of immunochromatography detection. The diluent solves the technical problems of unsmooth chromatography, background interference, poor stability of detection results and the like caused by red blood cells during direct detection of whole blood samples. The diluent comprises a buffer system, an osmotic pressure regulator glycine, a nonionic surfactant polysorbate, an erythrocyte aggregation inducer polyvinylpyrrolidone, a dynamic viscosity regulator trehalose, a blocking protein, a stabilizer combination L-methionine and L-histidine, and a composite formula of water. Red blood cells are effectively induced to gather and intercept on the sample pad through the synergistic effect of all the components, and meanwhile the stability of the chromatography process and the activity of the detection reagent are maintained. The diluent is mainly used for lateral immunochromatography quantitative detection of markers such as pro-enkephalin, C-reactive protein, cardiac troponin I or N-terminal pro-brain natriuretic peptide in a whole blood sample.

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The application discloses a kind of bumetanide tablets, raw materials include bumetanide 1 according to mass ratio;Corn starch 81~85;Lactose 50~54;Agar 0.1~0.3;Povidone K304~6;Polysorbate 80, 0.1~0.2;Silicon dioxide 3~4.5;Talcum powder 2~3.3;Magnesium stearate 0.3~0.7.Its preparation method includes the following steps: pretreatment, premixing, granulation, wet granulation, drying, dry granulation, total mixing, tabletting and packaging.The application introduces the synergistic system of trace agar and polysorbate 80 in the prescription.Agar, as a natural hydrophilic colloid, can form a hydrophilic network structure during the granulation process, and synergistically act with polysorbate 80, greatly improving the wettability and dispersibility of the slurry to ultrafine bumetanide, preventing drug agglomeration, so that the drug can be more evenly distributed in the granules during the subsequent drying and tabletting process.

The invention discloses an oyster enzymolysis ultrafiltration extract nasal spray and a preparation method thereof, the nasal spray comprises the following components: 5-10 wt% of oyster extract, 0.1-0.3 wt% of preservative, 0.05-0.15 wt% of sodium chloride and 0.1-0.3 wt% of emulsifier, the pH value is 5.5-6.5, the content of the preservative is 0.1-0.3 wt%, the content of the sodium chloride is 0.05-0.15 wt%, the content of the emulsifier is 0.1-0.3 wt%, and the balance is water. The preservative is one of benzalkonium chloride, sorbic acid and potassium sorbate, and the emulsifier is polysorbate 80. Through definite raw material composition, a step-by-step process and quality control, the bioavailability of active components is improved, the flavor of the product is optimized, the effect of safely and efficiently improving sleep is achieved, the problems of low bioavailability, poor flavor and potential safety hazards of an existing sleep improving product are solved, the process repeatability is high, and the preparation method is suitable for industrial production. The long-term use of people with chronic insomnia is facilitated.

This application relates to the field of feed processing technology and discloses a highly absorbable feed composition for nursery pigs containing compound probiotics. The composition includes the following ingredients: a basal diet, a live bacteria compound powder composed of freeze-dried *Lactobacillus plantarum* powder and freeze-dried *Bacillus coagulans* powder, medium-chain triglycerides, a PIT-responsive compound emulsifier composed of polysorbate-80 and sorbitan monooleate, anhydrous trehalose, glycerol, a micron-sized confinement carrier, which is a porous carrier obtained by high-temperature expansion and vacuum degassing of perlite powder, and fumaric acid. This invention employs anhydrous trehalose and glycerol to construct a high-permeability system, combined with medium-chain triglycerides and a compound emulsifier to form an oil-phase encapsulation, achieving the technical effect of effectively blocking external moisture penetration and improving the heat resistance of the bacteria.

The invention relates to a detection method, in particular to a method for detecting aldehyde impurities in polysorbate 20. According to the method, interference caused by the purity of 2, 4-dinitrophenylhydrazine is avoided, derivatization of a reference substance is performed by adopting a method synchronously operating with a test sample, eight aldehyde ketone substances can be detected at the same time, and compared with literature methods, the method is high in specificity, good in precision, high in accuracy, simple and easy to implement and high in operability.

This invention belongs to the field of cosmetic technology and discloses a composition containing polypeptides, its preparation method, and its application. The composition provided by this invention comprises: polypeptides and a solubilizing and penetration-enhancing complex; the polypeptides include at least one selected from Codonopsis pilosula cyclic peptide B, conopeptide, carnosine, acetyl tetrapeptide-5, acetyl hexapeptide-8, and nonapeptide-1; the solubilizing and penetration-enhancing complex comprises the fermentation product filtrate of Kluyveromyces lactis / Ganoderma lucidum fruiting body extract, polyols, polysorbate, and ferulic acid. The composition provided by this invention, through the synergistic effect between its components, can effectively improve the solubility and stability of the polypeptides, preventing precipitation or exudation, while effectively promoting the transdermal absorption of the polypeptides; the composition provided by this invention has excellent antioxidant and anti-aging effects.

The present application relates to the technical field of pharmaceutical preparation, and provides a calcium carbonate tablet, which comprises the following raw materials in parts by weight: 700-800 parts of calcium carbonate, 80-100 parts of corn starch, 15-25 parts of low-substitution hydroxypropyl cellulose, 1.5-2.5 parts of polysorbate-80, 7-9 parts of protein sugar, 3-5 parts of hypromellose, 2.5-3.0 parts of magnesium stearate and 15-25 parts of sodium carboxymethyl starch; wherein the calcium carbonate is selected from calcium carbonate with a particle size of 40-80 μm; the low-substitution hydroxypropyl cellulose and the sodium carboxymethyl starch are disintegrants, and the ratio of the amount of the low-substitution hydroxypropyl cellulose to that of the sodium carboxymethyl starch is 1:1. The present application also provides a preparation method of the calcium carbonate tablet. The calcium carbonate tablet has the advantages of short disintegration time, high dissolution rate, good bioavailability and good stability.

The application belongs to the technical field of biological medicine, and particularly relates to a freeze-dried preparation based on synergistic effect of trehalose and arginine for optimizing the performance of omalizumab reconstitution and a preparation method thereof. The preparation method comprises the following steps: preparing a histidine-hydrochloric acid buffer, dissolving omalizumab, trehalose, arginine and polysorbate 20 in the histidine-hydrochloric acid buffer to prepare a solution preparation; and freeze-drying the solution preparation to obtain the freeze-dried preparation; wherein the molar concentration ratio of trehalose to arginine in the solution preparation is 10-90:15-55. The freeze-dried preparation obtained by using the preparation method has a fast reconstitution speed and a fast bubble disappearance speed during reconstitution, can save time, meets the clinical emergency drug demand, and is more convenient to use.

A composition comprising an oily medium system and an active ingredient, and a method of increasing the bioavailable rate of an active ingredient, where the method comprises incorporating the active ingredient into an oily medium system, and where the oily medium system contains a vegetable oil and / or a component of a vegetable oil, the liquid does not contain the following substances: a phosphate buffer solution, polyethylene glycol, dimethyl sulfoxide, ethanol, polypropylene glycol, polysorbate, ethyl acetate, 12-hydroxystearic acid hydroxyethyl ester and tocopherol polyethylene glycol succinate; the active ingredient is selected from the group consisting of compounds of formula (I) wherein T1 is a C6 cyclic hydrocarbon and R1 is a C1-C8 aliphatic hydrocarbon group, pharmaceutically acceptable salts thereof, and combinations thereof.

The invention belongs to the field of papermaking, and particularly relates to an ink composition for food paper, which comprises resin, a first flavor agent, a second flavor agent, a first emulsifier, a second emulsifier and an organic solvent, the first flavor agent comprises a sweetening agent and a salty agent; the second flavor agent comprises an acidulant; the first emulsifier is selected from one or more of polyglycerol monooleate and sorbitan fatty acid; the second emulsifier is selected from one or more of polysorbate and triglycerol fatty acid ester; the mass content of the first emulsifier in the ink composition is 2%-6%; and the mass content of the second emulsifier in the ink composition is 2-6%. The invention also relates to a preparation method of the ink composition for the food paper, the food paper and a printing method thereof, and application of the ink composition. The ink composition disclosed by the invention is high in stability and has the flavor of coordinating and fusing sweet taste, salty taste and sour taste, and the flavor is continuously kept and is not easy to attenuate.

The invention belongs to the technical field of traditional Chinese medicine navel patches, and particularly relates to a composite medicine carrying navel therapy patch based on a PU film and a preparation method thereof.The composite medicine carrying navel therapy patch comprises an anti-sticking release film, a medicine carrying layer, a medical pressure-sensitive adhesive layer and a PU waterproof protective layer; the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 to 20 parts of rhizoma zingiberis, 10 to 15 parts of roasted rhizoma atractylodis macrocephalae, 8 to 12 parts of radix codonopsis, 5 to 10 parts of fructus evodiae, 5 to 10 parts of fructus foeniculi, 3 to 8 parts of cortex cinnamomi, 1 to 3 parts of borneol, 8 to 20 parts of polysorbate 80, 0.5 to 2 parts of carbomer 940, 1 to 3 parts of triethanolamine and 0.1 to 0.5 part of EDTA-2Na. By means of the integrated design of slow-release hydrogel drug loading and the multi-layer patch, efficient transdermal absorption and stable release of drugs are achieved, and the bioavailability and application comfort of the composite drug-loading navel therapy patch are improved.

The invention discloses a sweet-scented osmanthus and calendula child face cream for relieving allergy, moistening and repairing skin barrier and a preparation method thereof, and relates to the technical field of cosmetics. Osmanthus flower extract, calendula flower extract, coleus forskohlii root extract, radish seed extract, radix gentianae extract, centella asiatica extract, butyrospermum parkii butter and sunflower seed oil which are plant-sourced are utilized; a rahnella / soybean protein fermentation product, sodium hyaluronate, allantoin, mannitol, arginine, microcrystalline cellulose, polysorbate-60, phenoxyethanol and water are supplemented, so that a layer of protective film can be formed on the surface of the skin. The sweet-scented osmanthus and calendula cream for children is prepared according to the skin characteristics of children, is safe and non-toxic, and can be safely used at ease.

The invention discloses a zingiberenone A-containing composition with repairing and anti-wrinkle effects and a preparation process of the zingiberenone A-containing composition. The composition is prepared from the following components in percentage by weight: 0.0015 percent to 2 percent of zingiberenone A, 30 percent to 40 percent of glycerol, 30 percent to 40 percent of propylene glycol, 10 percent to 20 percent of polysorbate-80 and 10 percent to 20 percent of PEG-60 hydrogenated castor oil. The preparation process comprises the following steps: mixing the components, heating in a water bath at 40-50 DEG C, and ultrasonically stirring until the components are completely dissolved. Through specific auxiliary material compounding and process, the technical bottleneck of poor water solubility of zingiberenone A is overcome, so that zingiberenone A can be stably applied to cosmetics. Human body efficacy evaluation proves that the composition containing 0.0015% of zingiberenone A has remarkable anti-wrinkle, firming, moisturizing and soothing effects; the composition containing 0.015% of the composition has significant skin barrier repairing, moisturizing and soothing effects, and is mild and non-irritant. According to the invention, stabilization and efficacy verification of zingiberenone A in cosmetics are realized for the first time.

The present invention generally pertains to methods of quantifying free fatty acids in a pharmaceutical formulation. In particular, the present invention pertains to a method of quantifying free fatty acids released from polysorbate hydrolysis in a pharmaceutical formulation comprising a pharmaceutical product, polysorbate and free fatty acids, using liquid chromatography-mass spectrometry, without the use of an extraction step.

A cyclocurcumin-based composition consisting of: a cyclocurcumin component present at 20 to 40 wt% of the total composition; a curcuminoid component present at 30 to 50 wt%, comprising 20 to 30 wt% curcumin, 5 to 10 wt% demethoxycurcumin, and 3 to 8 wt% bisdemethoxycurcumin; a solubilizer component present at 5 to 15 wt%, comprising polysorbate at 3 to 8 wt% and lecithin at 3 to 7 wt%; a complexing component present at 5 to 12 wt%, comprising cyclodextrin inclusion complexes; and a nanoparticulate component present at 3 to 10 wt%, comprising cyclocurcumin particles with a particle size in the range of 50 nm to 200 nm. consists of a polymer stabilizing component, which is present in an amount of 4 to 10 wt.-% is present and comprises polyvinylpyrrolidone or polyethylene glycol, a phospholipid complex component present in an amount of 3 to 8 wt% and consisting of phosphatidylcholine complexes, and an encapsulation component present in an amount of 2 to 6 wt% and containing maltodextrin or gum arabic, the composition being configured to ensure improved solubility, stability and bioavailability.

The present invention relates to insulin formulations comprising polysorbate 80. The present invention provides, inter alia, aqueous liquid pharmaceutical formulations comprising insulin or an insulin analogue, ionic zinc, a chelating agent, and polysorbate 80.

The invention provides an antibacterial dressing composition and a medical gynecological protection pad, and belongs to the technical field of medical dressings. The composition is prepared from 70 to 90 parts of water, 8 to 10 parts of polyethylene glycol, 4 to 6 parts of glycerol, 0.3 to 0.7 part of carbomer, 0.06 to 0.15 part of L-cysteine, 4 to 8 parts of chitosan quaternary ammonium salt, 0.3 to 0.8 part of panthenol, 0.4 to 0.7 part of tocopheryl acetate, 0.2 to 0.4 part of sodium hyaluronate, 0.1 to 0.3 part of chlorhexidine digluconate, 3 to 4 parts of polyvinylpyrrolidone, 1 to 5 parts of sodium alginate, 0.1 to 0.3 part of polysorbate, 0.6 to 0.9 part of luteoloside, 0.1 to 0.2 part of quercetin and 0.05 to 0.2 part of sophocarpidine. Chitosan quaternary ammonium salt and chlorhexidine digluconate are used as bactericidal components, quercetin and sophocarpidine are added to serve as bacteriostatic agents, and the bactericidal components, active components such as panthenol, tocopheryl acetate and galuteolin and a film-forming agent form a dispersion system. The antibacterial facial mask has remarkable antibacterial property, and has the effects of resisting inflammation, preserving moisture, promoting tissue repair and the like. The gynecological protection pad acts on the surface of vulva inflammation, and the exact treatment effect can be achieved.

The application discloses a method for detecting the dissolution curve of ezetimibe and rosuvastatin calcium tablets, and belongs to the technical field of drug detection. The method uses an aqueous solution containing 0.1-0.3 wt% polysorbate 80 as a dissolution medium, and performs dissolution according to a dissolution instrument basket method, wherein the rotating speed of the rotating basket is 50-100 revolutions per minute, and the mesh number of the rotating basket is 10 meshes. The method provided by the application has good dissolution for both ezetimibe and rosuvastatin calcium, and has the characteristics of strong specificity, high sensitivity, high accuracy, good durability and the like, can effectively distinguish the difference between self-prepared preparations and reference preparations, and is more universal and practical, and is more simple and efficient in operation.

The invention discloses a reversible thermochromic phase change capsule heat storage material and a preparation method thereof, and belongs to the technical field of thermochromic phase change energy storage capsule coating. A core material of the thermochromic phase change capsule is a sodium alginate-based thermochromic phase change emulsion formed by polysorbate-80 emulsified 3, 3-bis (4-dimethylaminophenyl)-6-dimethylaminophenyl peptide, 2, 2-bis (4-hydroxyphenyl) propane, an alcohol phase change material and a sodium alginate solution, and the thermochromic phase change capsule is prepared from the sodium alginate-based thermochromic phase change emulsion. The wall material of the thermochromic phase change capsule is calcium alginate generated by carrying out ion exchange reaction on sodium alginate and Ca < 2 + > in a CaCl2 solution. A non-toxic and low-cost natural biopolymer sodium alginate is selected as a base material for stabilizing the thermochromic phase change material, and generated calcium alginate is selected as a shell material. The material can flexibly respond to color change along with temperature change, the photo-thermal interface synergism is good, the photo-thermal conversion efficiency is high, and the application potential of reversible thermochromic phase change capsules in the fields of temperature indication, anti-counterfeiting marks, thermal management systems, solar photo-thermal utilization and the like is greatly expanded.

The invention provides a rivastigmine new-form salt compound and a preparation method of a rivastigmine new-form salt compound preparation. The rivastigmine new-form salt compound is prepared from the following rivastigmine salt and auxiliary materials in percentage by mass: 1.5%-3% of rivastigmine salt, 5%-10% of polysorbate 20, 1%-8% of polyethylene glycol-4000, 0.15%-1.5% of citric acid, 0.5%-1.0% of anhydrous disodium hydrogen phosphate, 0.1%-0.5% of sodium hydroxide and 80%-90% of water for injection. The invention also discloses a method for preparing a preparation by using the compound. The preparation process of the preparation disclosed by the invention is simple, is suitable for large-scale production of enterprises, and has great market development prospects. The preparation disclosed by the invention adopts a new administration mode, and the characteristics of the preparation are utilized, so that the medicine is slowly dissolved out subcutaneously; therefore, the purpose of reducing side effects of intestinal tracts is achieved. The preparation disclosed by the invention is stable in blood concentration and good in tolerance.

The invention discloses an ellagic acid composite solid dispersion and a preparation method thereof. The preparation method comprises the following steps: S1, respectively preparing a fucoidin aqueous solution and an ellagic acid ethanol suspension; s2, mixing the two solutions to obtain a mixed solution; s3, adding the modified polysorbate 20 and the chitosan-CPP compound, and performing ultrasonic stirring; s4, ball milling; and S5, carrying out reduced pressure rotary evaporation to remove the solvent, drying, crushing, and sieving with a 100-mesh sieve to obtain the product. Ternary synergistic compounding is formed through the fucoidin-modified polysorbate 20-chitosan-CPP compound, a multi-dimensional molecular interaction network is constructed, and the effect of remarkably improving the water solubility and dispersion stability of ellagic acid is achieved; wherein xylooligosaccharide branched chains of the modified polysorbate 20, hydroxyl groups of the fucoidin and phosphate groups of the chitosan-CPP compound form a multi-point hydrogen bond cross-linked structure through hydrogen bonds, and the hydrophobic association effect and lattice stacking among ellagic acid molecules are broken through the steric hindrance effect.

According to the present invention, by using polysorbate and polyethylene glycol in combination, the solubility of a thiazolidinedione-based compound, particularly a thiazolidinedione-based compound having PPAR-γ agonistic activity, can be effectively improved. Therefore, the compound can be maintained in a homogeneous state in a composition without precipitation or crystal formation, and formulation stability suitable for local injection or local application can be ensured. In addition, the composition of the present invention can stably maintain the dissolved and dispersed state of the thiazolidinedione-based compound even at a low surfactant concentration, and thus can improve the reproducibility and application suitability of the formulation.

The invention discloses a plant essence composition for brightening and whitening as well as a preparation method and application thereof. The composition is prepared from the following components in percentage by weight: 3 to 6 percent of a polygonatum odoratum root extract, 1 to 3 percent of a pomegranate extract, 1 to 3 percent of a mulberry root bark extract, 3 to 6 percent of a polygonum cuspidatum root extract, 30 to 40 percent of polysorbate-20, 30 to 40 percent of butanediol and 20 to 30 percent of water. The preparation method comprises the following key steps: performing cryogenic embrittlement and low-temperature airflow superfine grinding on four plant raw materials, and performing low-temperature directional extraction by adopting compound enzyme; carrying out two-stage centrifugation and deep filtration on the extracting solution, specifically collecting a target precipitate under the ethanol concentration of 65% by virtue of a multi-stage gradient alcohol precipitation process, and washing and purifying by virtue of a 80% ethanol solution; and performing high-pressure homogenization on the purified active matter to construct a layered liquid crystal structure, performing membrane filtration and low-temperature instantaneous sterilization in sequence to perform terminal refining, and finally performing sterile filling to obtain the product.

The present invention relates to liquid pharmaceutical compositions of a VEGF antagonist for intravitreal administration comprising a histidine buffer, an inorganic salt, a carbohydrate and a polysorbate.

The application discloses a polymer electrolyte and a preparation method thereof, a polysorbate and a preparation method and application thereof. The polymer electrolyte comprises a polymer base, a lithium salt and an additive; the additive comprises a polysorbate. The polymer electrolyte disclosed by the application has good ionic conductivity and good mechanical properties, and is thus beneficial to improving the cycle performance of a battery.

This invention provides a pharmaceutical composition containing hezemibrate and an HMG-CoA reductase inhibitor, and may further include one or more excipients selected from calcium carbonate, butylated hydroxyanisole, butylated hydroxytoluene, citric acid, sodium lauryl sulfate, polysorbate, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, hydroxypropyl cellulose, lactose, pregelatinized starch, magnesium stearate, and talc. This composition can be formulated into various dosage forms, exhibiting good formulation stability and controllable quality.

The invention relates to the technical field of anti-aging compositions, and discloses a preparation method of a water-soluble anti-allergy anti-aging composition, which comprises the following steps: mixing peony flower water, peony branches, a peony root bark extract, a peony root extract, butanediol, 1 part by weight of glycerol, polysorbate-20, ergothioneine, inositol, a mussel extract, 1, 2-propylene glycol and water to obtain a mixture; and adding 1, 2-hexanediol, modified sinapic acid, the essence extract and the intermediate 1 into a stirrer, and stirring to obtain the water-soluble anti-allergy and anti-aging composition. The amino acid contained in the intermediate 1 in the water-soluble anti-allergy and anti-aging composition can effectively improve the skin, and has an excellent whitening effect and a good moisturizing effect; wherein the peony flower water, the peony branches, the peony root bark extract, the peony root extract, the butanediol, the glycerol, the polysorbate-20, the ergothioneine, the inositol and the mussel extract have the effects of repairing, nourishing, relieving, resisting wrinkles and tightening.

The application discloses a biomass quantum dot enabled double-effect grading repair whitening and anti-aging mask formula and a preparation method thereof. The formula comprises a cleaning and anti-irritation mask and a functional mask. The cleaning and anti-irritation mask and the functional mask both comprise the following raw materials: water, glycerol, propylene glycol, butylene glycol, 1,2-hexanediol, 1,2-pentanediol, tripartite grass leaf / root extract, dandelion leaf extract, p-hydroxyacetophenone, radix stephaniae tetrandrae extract, ethylhexylglycerin, polysorbate-80, palmitoyl pentapeptide-4, ethanol, umbilical cord extract, phenoxyethanol, hydrolyzed placenta extract, palmitoyl tripeptide-1, sodium hyaluronate, hydroxyethyl cellulose, disodium hydrogen phosphate, sodium dihydrogen phosphate, polysorbate-60, sodium polyglutamate, tremella fuciformis fruiting body extract and biomass quantum dots. The biomass quantum dots are added in an amount of 0.5-1.2 parts by weight in the cleaning and anti-irritation mask and in an amount of 1.0-1.7 parts by weight in the functional mask.

The invention belongs to the technical field of medicines, and relates to a namiklast preparation oil-in-water composition locally applied to skin as well as a preparation method and application of the namiklast preparation oil-in-water composition. Comprising the following components in parts by mass: 0.1-2 parts of namiklast, 5-10 parts of stearic acid, 10-25 parts of caprylic / capric polyethylene glycol glyceride, 5-15 parts of diisopropyl adipate, 15-30 parts of diethylene glycol monoethyl ether, 0.5-2 parts of polysorbate, 5-12 parts of glycerol, 0.2-2 parts of phenoxyethanol and 30-60 parts of purified water. The composition is applied after a mixed gas of heptafluoropropane and tetrafluoroethane is pressed in a pressure container to release foam by taking the mixed gas of heptafluoropropane and tetrafluoroethane as a propellant. The invention provides a foam type medicament which can be applied on the body surface. The foam type medicament has the advantages that foams can be effectively formed, the foam holding time is long, the foaming amount is large, the foam density is small, the foam breaking speed is slow, the particle diameter of suspended particles in the composition is stable, and the dissolving or suspending state of active medicines in liquid medicine is kept stable.