71 results about "Rosacea" patented technology

The invention provides a facial skin flaw enhancement method based on a Lab color space. The method comprises the following steps: firstly, acquiring an RGB face image and converting the RGB face image into a CIE Lab color space with uniform perception; then, performing differentiation treatment according to the manually selected skin flaw type: for the vascular flaw, extracting statistical characteristics of a component and driving adaptive nonlinear transformation, and generating a grey-scale map which highlights the red flaw; for pigment flaws, nonlinear transformation is carried out on the component L, and then collaborative linear weighting and feature amplification are carried out on the component L, the component a and the component b, so that a grey-scale map with highlighted pigment spots is generated. And finally, coloring the grey-scale map in the Lab color space through adjustable parameters to generate a high-contrast color enhanced image. The method overcomes the dependence on hardware and training data in the prior art, can clearly and adaptively enhance various flaws such as acnes, couperose streaks and color spots, shows robustness under different illumination, and can be widely applied to clinical beauty, later photography and real-time video processing.

Disclosed herein are compositions which can be used in methods for treating or preventing ophthalmic and dermatologic conditions in a human subject, including ocular surface conditions such as blepharitis or rosacea. The compositions can be topically administered directly to an eye, eyelid, or eyelashes of the patient for targeted local activity.

The invention discloses a poria cocos and flower multiple healing formula as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. Comprising poria cocos, honeysuckle, scutellaria baicalensis, gallnut, sanguisorba officinalis, lithospermum erythrorhizon and mirabilite. In the formula, the poria cocos has the effects of tonifying spleen, promoting diuresis, calming heart and tranquilizing mind; the honeysuckle flowers have the effects of clearing away heat and toxic materials and dispelling wind and heat; the radix scutellariae has the effects of clearing heat, drying dampness, purging fire and detoxifying; the gallnuts have the effects of clearing lung, reducing fire, clearing damp and healing sore; the radix sanguisorbae has the effects of cooling blood, stopping bleeding, detoxifying and healing sore; in the treatment process of rosacea, the formula can effectively relieve inflammation and improve skin conditions through the effects of clearing away heat and toxic materials, resisting microorganisms, resisting viruses and the like; the problems that in the prior art, the treatment effect on rosacea is unstable, and side effects are large are solved.

This invention discloses an acne-repairing and repairing composition for promoting microcirculation in acne-prone and sensitive skin, and its application, relating to the field of cosmetic technology. The invention provides an acne-repairing and repairing composition comprising the following components in parts by weight: Vitamin K2 0.05-1 parts, Swertia japonica extract 0.1-1.5 parts, Guaiac extract 0.1-2 parts, Cerium oxide microspheres 0.005-0.1 parts, and Morus alba root extract 0.5-5 parts; wherein the average particle size of the Cerium oxide microspheres is 0.2-3 μm, and the Cerium oxide microspheres contain Ce. 3+ The Ce 3+ The molar percentage of cerium oxide microspheres is 30-38%. This invention provides an acne-repairing composition. In actual experiments, the inventors discovered that when vitamin K2, Swertia trifasciata extract, Guaiac extract, cerium oxide microspheres, and mulberry root extract are present simultaneously, the five components can synergistically work together to reduce skin roughness and improve rosacea and acne.

The invention discloses a SerpinB3 inhibitor and an application of the SerpinB3 inhibitor. The phloretin can be used as the SerpinB3 inhibitor for the first time, can effectively relieve the symptoms of the rosacea and the psoriasis at the same time, and is used for preparing related drugs for treating inflammatory skin diseases such as the rosacea and the psoriasis. The invention provides a certain theoretical basis for research and development of related treatment products for inflammatory skin diseases such as rosacea or psoriasis.

The invention provides a composition comprising a plant or fungal extract in combination with a xanthone compound. Such a composition is for use in reducing lipid levels in sebocytes, and the composition may find use in treating acne vulgaris and rosacea. The composition may comprise (a) a xanthone compound according to formula (I), or a pharmaceutically or cosmetically acceptable salt, prodrug, solvate, tautomer or stereoisomer thereof; and (b) a plant or fungal extract selected from extracts of plants belonging to the genus Arctostaphylos, Hedera, Ilex, Fragaria and Rubus and extracts of the fungus Wolfiporia, (I) where each of R1 to R8 are described herein.

The invention relates to a cosmetic composition, advantageously an ecobiological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by general formula (I), in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an α-amino acid selected from the group consisting of: tryptophan, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The invention also relates to the use of the cosmetic composition for combatting skin redness and / or skin ageing; to the use thereof for preventing and / or combatting cutaneous hypervascularisation and / or skin inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combatting these conditions.

Provided herein are compositions and their use for the treatment of human skin, particularly facial skin, to alleviate the symptoms of cosmetic or dermatologic skin conditions. The compositions include black willow bark extract, cat's claw extract, and dragon's blood extract. The compositions ameliorate skin conditions including acne, rosacea, blemish, dermatitis, eczema, or the like.

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

The present invention relates to pharmaceutical compositions and methods for obtaining said pharmaceutical compositions comprising a conditioned culture medium of human mesenchymal stem cells and / or a combination of trophic factors expressed by human mesenchymal stem cells, and a polymeric matrix of hyaluronic acid. The present invention also relates to methods for preventing and / or treating patients having pathologies that generate tortuous vessels, or complications from the appearance of tortuous vessels, such as varicose veins, psoriasis, hemorrhoids, rosacea, acne, crystal skin, atopic dermatitis, among others.

Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipoloar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss.

1. Name of the product subject to this design: Laser Therapy Machine (YL900-2024). 2. Application of this design: for use in the medical aesthetics industry for skin rejuvenation, freckle removal, pigmentation reduction, and treatment of rosacea. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. The bottom surface of this product is a part that is not easily seen or cannot be seen during use, so the bottom view is omitted.

The disclosure demonstrates the role of mast cell stabilizers in treating rosacea. The disclosure also shows the role of mast cells, cathelicidin, serine protease and / or vitamin D3 in rosacea pathology and the use of antagonists and inhibitors thereof to treat rosacea.

A method of topically applying to skin a composition comprising a water soluble Phoenix dactylifera seed extract, an essential oil from the leaves of tea tree, an aqueous Myrothamnus flabellifolia leaf and stem extract, and a saccharide isomerate comprising an exopolysaccharide of Vibrio alginolyticus is disclosed.

This invention provides the application of ginsenoside Rh1 in the treatment of inflammatory skin diseases, belonging to the field of biomedical technology. It is the first to demonstrate that ginsenoside Rh1 inhibits AQP3 expression by activating the oxidative phosphorylation pathway and regulating cellular homeostasis, thereby inhibiting AQP3 gene transcription and / or expression. As a novel AQP3 inhibitor, it downregulates AQP3 protein expression levels in an animal model of rosacea. This provides a novel strategy and drug candidate for targeted therapy of rosacea and other AQP3-related inflammatory skin diseases.

The invention discloses a traditional Chinese medicine composition for adjuvant therapy of hops caused by damp-heat and insect toxicity and a preparation process thereof, and the traditional Chinese medicine composition for adjuvant therapy of hops caused by damp-heat and insect toxicity is mainly prepared from the following traditional Chinese medicine raw materials by weight: 400-600g of radix sophorae flavescentis, 400-600g of cortex phellodendri chinensis, 400-600g of radix stemonae, 300-500g of fructus cnidii, 200-400g of smoked plum, 30-50g of borneol and 15-35g of sulfur. The invention further discloses the preparation method of the traditional Chinese medicine composition for adjuvant therapy of the alcohol thorns caused by damp-heat and insect toxins. The liniment is proper in medicine selection, refined for external use, capable of quickly reaching the affected part with medicine efficacy, quick in effect and convenient to use; both symptoms and root causes can be treated; side effects are few. And the traditional Chinese medicine composition has a remarkable curative effect on acne rosacea (acne rosacea and acne) caused by damp-heat and insect toxicity.

The present disclosure provides methods and compositions for treating a disease or condition involving inflammation in the skin, e.g., atopic dermatitis, eczema other than atopic dermatitis, hidradenitis suppurativa, vitiligo, alopecia areata, scleroderma (including systemic sclerosis), dermatomyositis, epidermolysis bullosa, mastocytosis, keloids, acne, rosacea, or bullous pemphigoid, with a therapeutic dose of an anti-TNF-like ligand 1A (TL1A) antibody (Afimkibart).

The invention discloses a plant-derived HTR3A antagonist and application thereof in preparation of a medicine for treating rosacea, and belongs to the field of biological medicines.The plant-derived HTR3A antagonist is screened aiming at HTR3A targets, and finally four compounds (D, H, E and T respectively) with high affinity with HTR3A are obtained; under a rosacea model constructed by THP-1 cells stimulated by LL-37 and neurotransmitter 5-HT (L5), through mRNA level detection of HTR3A and further verification and screening of an immunofluorescent staining experiment, the compounds D and T are determined to have remarkable effects. The invention provides a novel plant source compound and a regulation scheme for treating nervous rosacea, and has important application value.

The invention provides a composition comprising a plant or fungal extract in combination with a phenol compound. Such a composition is for use in reducing lipid levels in sebocytes, and the composition may find use in treating acne vulgaris and rosacea. The composition may comprise (a) a phenol compound according to formula (I), or a pharmaceutically or cosmetically acceptable salt, prodrug, solvate, tautomer or stereoisomer thereof; and (b) a plant or fungal extract selected from extracts of plants belonging to the genus Arctostaphylos, Fragaria, Garcinia, Hedera, Ilex, and Rubus, and extracts of the fungus Wolfiporia, (I) where each of R1 to R5 and -L- are as described herein.

The invention relates to application of cembratrienediol in preparation of a medicine for preventing and treating rosacea, and belongs to the technical field of biological medicine. The invention provides an application of cembratrienediol in preparation of a medicine for preventing / or treating rosacea. The cembratrienediol can obviously improve erythema and inflammation of an injection area of a rosacea mouse model for a long time and a short time; the skin tissue pathological inflammation of the rosacea mouse model can be obviously relieved (including the thickening of the skin epidermis of the rosacea mouse model, the inflammatory cell infiltration of the skin tissue of the rosacea mouse model and the capillary hyperplasia of the skin tissue of the rosacea mouse model); skin inflammation of a rosacea patient can be remarkably relieved (including relieving pain of the skin of the rosacea patient and relieving the red and swollen degree of the skin of the rosacea patient), and skin injuries of the rosacea patient can be remarkably improved (including improving papules and pustules of the skin of the rosacea patient).

The present invention relates to a method for inducing, stimulating, and / or promoting the healing of a wound or damaged skin area, comprising topically treating a subject's skin surrounding the wound or damaged skin area with conditioned medium derived from a culture of umbilical cord mesenchymal stem cells. Similarly, the present invention relates to a method for preventing the formation and / or recurrence of wounds or damaged skin areas in a subject at risk of developing wounds or damaged skin areas, comprising topically treating the subject's skin with conditioned medium derived from a culture of umbilical cord mesenchymal stem cells. Furthermore, the present invention relates to a method for treating skin damage caused by rosacea, psoriasis, eczema, dermatitis, topical steroid withdrawal syndrome, epidermolysis bullosa, or fragile skin, comprising topically treating a subject's skin surrounding the wound or damaged skin area to be treated with conditioned medium derived from a culture of umbilical cord mesenchymal stem cells. The present invention is also directed to the conditioned medium, uses thereof, compositions comprising it, methods for producing the conditioned medium, and uses of these compositions.

The utility model relates to a sampling device for identifying rosacea. The sampling device comprises a sampling belt and a release film covering the sampling belt; the sampling belt is in a belt shape and is formed by sequentially arranging a plurality of sampling units; each sampling unit comprises a rectangular flexible bearing sheet and a circular flexible sampling sheet; the adjacent bearing sheets are connected in a point-breaking manner; the diameter of the sampling piece is smaller than the width of the bearing piece, and the sampling piece is stacked and fixed at the central area of the main plane of the bearing piece; an adhesive layer is arranged on the main plane, opposite to the bearing sheet, in the sampling sheet; the release film is strip-shaped and is formed by sequentially arranging sub-release films with the same number as the sampling units, and the adjacent sub-release films are connected in a point breaking manner; and the sub release films cover the adhesive layer and are symmetrically arranged with the corresponding bearing sheets. When the sampling device is used for sampling, extra cutting is not needed, the operation is simpler and more convenient, and the probability that a sample is polluted is reduced.

A metronidazole derivative of formula I, a preparation method, and a use in preparation of a drug. The metronidazole derivative can effectively ameliorate the symptoms of rosacea. Moreover, compared with metronidazole, the metronidazole derivative has less medication dosage and low medication frequency, but still can achieve a better improvement effect. Therefore, the metronidazole derivative has the prospect of being developed into a drug for ameliorating the symptoms of rosacea. The preparation method for the metronidazole derivative involves simple steps and mild conditions, and is easy for industrial production.

The invention discloses a pharmaceutical composition for rosacea as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from radix bupleuri, radix scutellariae, cortex cinnamomi, honey-fried licorice root, rhizoma zingiberis, radix trichosanthis, nacre mother of pearl, oyster, cornu bubali and cortex moutan. The pharmaceutical composition obtains a satisfactory clinical curative effect in clinical treatment, has a remarkable clinical curative effect and small side effects when being used for treating and / or preventing neurogenic rosacea, and has a wide market and application prospect.

To provide a composition for use in the treatment or prevention of pathogenic infections, rosacea, eczema and psoriasis in humans or animals.SOLUTION: There is provided a composition comprising benzalkonium halide; didecyldimethylammonium halide; polyhexamethylene biguanide salt; bronopol; and p-chloro-m-cresol.SELECTED DRAWING: None

The invention discloses preparation and application of a double-enzyme-driven stage response type external preparation, which comprises the following steps: preparing drug-loaded hyaluronic acid (HA) microspheres, namely constructing emodin (EMD)-loaded hyaluronic acid microspheres (EMD-HA microspheres) for a responsive traditional Chinese medicine external preparation; preparation of hyaluronidase (HAase) gelatin microspheres; preparing a medicine-containing ointment substrate; and carrying out magnetic stirring or mechanical homogeneous stirring on the obtained EMD-HA microspheres, HAase gelatin microspheres and an ointment matrix for 30 minutes at room temperature on the basis of a dosage ratio, so that the microspheres are fully and uniformly dispersed in the ointment matrix, thereby obtaining the dual-enzyme driven stimulus-responsive external preparation. According to the preparation disclosed by the invention, 'targeted response 'treatment aiming at different stages of rosacea is realized; the convenience and compliance of treatment are improved, and meanwhile, individualized precise treatment for rosacea is realized.

The present invention describes new cosmetic, cosmeceutical and / or pharmaceutical compositions, as well as their uses and useful methods for alleviating conditions arising from inflammatory processes, sensitive skin, rosacea, atopic dermatitis, eczema, and / or for alleviating the sensation of discomfort and pain, modulating the CB2 receptor, and / or for improving problems relating to cutaneous hyperchromia and disorders relating to increased sebogenesis.

The present disclosure relates to compositions and methods useful for dietary augmentation to provide therapeutic intervention for the amelioration of symptoms associated with rosacea-prone skin. According to one embodiment of the present disclosure, there is provided an orally administrable composition containing a therapeutically effective amount of: (a) a probiotic blend of bacterial components containing at least: (i) Lactobacillus helveticus, (ii) Lactobacillus plantarum, (iii) Bifidobacterium longum, and (iii) Streptococcus thermophilus; and (b) at least one plant-based, antioxidant-rich source of fiber.

The invention discloses application of vicenin-2 in preparation of a pharmaceutical preparation for treating and / or preventing rosacea, and belongs to the technical field of biological medicines. Vitin-2 blocks conduction of an IL-17 signal channel through targeted regulation and control of an IL-17RA / ACT1 / TRAF6 axis, further inhibits activation of an NF-kappa B signal channel, reduces levels of inflammatory factors TNF alpha, IL-6, IL-1beta and IL-8 induced by LL-37, inhibits expression of mRNA of TNF alpha, IL-6 and IL-1beta, inhibits phosphorylation of key protein of the channel, reduces protein expression levels of MMP1 and MMP3 at the downstream of the channel, and further inhibits activation of an NF-kappa B signal channel. Further, the effect of resisting the acne rosacea inflammatory response is achieved. Besides, the external vicenin-2 solution can relieve back erythema and angiotelectasis of a rosacea-like mouse model, pathological tissue section HE staining shows that the external vicenin-2 solution can relieve LL-37-induced skin inflammation infiltration, and the weight of a mouse is not obviously reduced compared with that before treatment; and the skin erythema and scales of mice are not generated by external use of the vicainin-2 solution.

The invention relates to the field of biological medicine, in particular to application of an IL7R inhibitor in preparation of a medicine for treating rosacea. The IL7R inhibitor comprises preparations for inhibiting the IL7R at the gene level and the protein level, the preparations for inhibiting the IL7R at the gene level comprise shRNA, siRNA, dsRNA, miRNA, cDNA and antisense RNA / DNA, and the preparations for inhibiting the IL7R at the protein level comprise small molecule compounds, peptides and antibodies. It is found for the first time that the targeted IL7R has a remarkable treatment effect on rosacea, the recurrence rate can be effectively reduced, and the skin lesion degree can be relieved. The discovery not only opens up a new direction for fundamental research of rosacea, but also provides a brand-new and breakthrough solution for clinical treatment of rosacea, and is expected to bring a more durable and stable treatment effect for patients.