131 results about "Pigmentations" patented technology

The invention provides application of UBR5 in preparation of drugs for treating pigmented skin diseases, and further the pigmented skin diseases comprise various types of pigmented nevus (mainly congenital pigmented nevus and megalous with the risk of malignant transformation). Various pigmented spots (mainly chloasma, freckles, Taitian nevus, post-inflammation hyperpigmentation and the like) and hypopigmentation / depigmentation spots (mainly leucoderma, post-inflammation hypopigmentation and the like). Experimental results show that UBR5 is highly expressed in disease tissues such as pigmented nevus. The UBR5 expression level and the melanogenesis ability are in significant positive correlation, targeted knockout / knockdown of UBR5 in melanocytes can significantly inhibit the expression level of melanogenesis related genes such as MITF, TRP1, TRP2, TYR and other proteins, the melanin content of melanocytes and tyrosinase activity, vice versa, and the melanogenesis ability of melanocytes after overexpression of UBR5 is significantly increased.

The invention provides an anti-aging and whitening pyracantha fortuneana fruit extract prepared by adopting a supramolecular solvent and a preparation method of the pyracantha fortuneana fruit extract, and relates to the technical field of biological extraction. The preparation method comprises the following steps: by taking betaine as a hydrogen bond acceptor and 1, 3-propylene glycol as a hydrogen bond donor, mixing and self-assembling the betaine and the 1, 3-propylene glycol to form a supramolecular solvent; and the pyracantha fortuneana fruits are extracted by adopting the supramolecular solvent. The pyracantha fortuneana fruit active ingredients are extracted by adopting the supramolecular solvent which is harmless to the skin, so that the irritation of the solvent to the skin can be avoided, the supramolecular solvent can be specifically combined with the active ingredients in the pyracantha fortuneana fruit, and the purity and activity of the active ingredients are improved. The pyracantha fortuneana fruit extract extracted by adopting the supramolecular solvent has better oxidation reduction resistance; generation of non-enzymatic glycosylation intermediate products is inhibited, and saccharification and aging resistance are facilitated; the red blood cell oxidative damage is improved, and the effects of resisting oxidation and relieving are achieved; the whitening mask has an inhibiting effect on elastinase and tyrosinase, and can resist aging, whiten skin, relieve facial pigmentation and brighten the skin.

The invention discloses a laser depilation dynamic parameter adjustment method based on skin typing recognition, and relates to the technical field of laser depilation, and the method comprises the steps: constructing a three-dimensional skin model of a depilation region through multi-dimensional data cross validation; detecting local pigmentation caused by friction in each area; detecting the blood flow signal intensity of capillary vessels around the hair follicles, judging the period of the hair and generating a hair follicle activity thermodynamic diagram in real time; a three-dimensional energy focus is formed through double-beam crossing; skin curved surface data are obtained through a pressure sensor, liquid crystal molecules in a light valve are driven to be arranged, and light spots are adjusted to be in the shape attached to an unhairing area; the basal metabolic rate of the patient is measured through a noninvasive bioelectrical impedance analysis technology, and the energy density is adjusted based on the basal metabolic rate; and establishing a digital twinborn model, and integrating depilation data, skin state and hormone level information. A three-dimensional energy focus is formed through double-beam crossing, energy is accurately focused on the root of the hair follicle, and epidermis damage is avoided.

The invention discloses a method for improving color and stability of anthocyanin through combination with punicalagin. The method comprises the step that punicalagin and anthocyanin are subjected to an intermolecular co-pigmentation reaction. According to the invention, punicalagin is adopted as a co-pigment molecule and is subjected to a co-pigmentation reaction with anthocyanin to form a punicalagin and anthocyanin compound, so that the color attribute of the anthocyanin is remarkably enhanced, and an anthocyanin solution presents brighter red color; the punicalagin and anthocyanin compound is prepared from punicalagin and anthocyanin, the heat stability, the light stability, the pH stability and the storage stability of anthocyanin are improved, the heat stability, the light stability and the storage stability of anthocyanin are further improved when the punicalagin and anthocyanin compound is prepared into microcapsules, and the punicalagin and anthocyanin compound has the advantages of being simple in process and low in cost. According to the invention, the utilization value of the anthocyanin is obviously improved, and a new thought is provided for the application of the anthocyanin in the food industry.

The utility model belongs to the technical field of medical instruments, and particularly relates to a cooling and analgesia device capable of being folded in a partitioned mode in a laser therapy operation, which is mainly used for cold compress of the face of a patient in the laser therapy operation. The device mainly comprises a flexible substrate which is provided with a hollow area; at least one side of each cold compress unit is connected with the flexible base layer, and the cold compress units are all located in the hollow area, so that the hollow area is covered with the cold compress units; wherein the cold compress unit is constructed to be capable of being folded relative to the flexible base layer, so that a part of the hollow area is exposed; the face cold compress device has the advantages that face cold compress is conducted on a patient in real time in an operation, so that the pain of the patient is relieved, and postoperative vesicles and hyperpigmentation are prevented.

The invention provides a novel composition and a preparation. The composition and the preparation comprise tranexamic acid and a vitamin A acid alcohol amine compound or a vitamin A acid fatty amine compound. After the composition is prepared into a preparation, the solubility of the vitamin A acid can be improved, the loss of the vitamin A acid in the preparation process is reduced, the content uniformity of the preparation is improved, and the stability of the preparation is improved; the composition can significantly increase the intradermal retention amount of vitamin A acid and tranexamic acid, and does not significantly increase the transdermal penetration amount of tranexamic acid. The composition and the preparation provided by the invention can significantly improve the curative effect and avoid aggravation of toxic and side effects in the treatment of hyperpigmentation and chloasma.

The invention relates to a whitening and repairing composition containing PDRN and polypeptide and application of the whitening and repairing composition. The composition comprises sodium hyaluronate, PDRN, polypeptide, vitamin C and cane sugar. Sodium hyaluronate, nucleic acid and polypeptide are adopted, so that the activity of collagen in the skin is enhanced, the moisture of cuticle and the integrity of a fiber structure are kept, the content of melanin in the epidermis is reduced, the skin barrier is repaired, the skin blood circulation is improved, anti-oxidation and anti-inflammatory treatment is performed, the skin color is brightened, and chromatosis is relieved, and sodium hyaluronate, nucleic acid and polypeptide are matched with one another; meanwhile, the release rate of nutritional ingredients is slowed down after the composition is injected into the skin, the action time is prolonged, and a better anti-degradation effect is achieved.

The invention provides an enhanced transdermal delivery beauty patch containing efficient active PDRN (DNA sodium) and a preparation method thereof, the enhanced transdermal delivery beauty patch is composed of a needle body layer and a backing layer, the needle body layer comprises the following components by mass: 5-15% of PDRN with a molecular weight of 50-300 kDa, 10-20% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight The content of the zwitterionic polymer carrier is 30%-50%, and the zwitterionic polymer carrier is formed by copolymerizing methacryloylethyl sulfobetaine and hyaluronic acid. The composition has the characteristics of good mechanical properties, rapid dissolution, high activity retention and efficient permeation promotion, can be used for treatment of pigmentation after acne and skin barrier repair, and comprehensively improves the skin repair effect and practicability.

The invention discloses a sialic acid mild brushing acid composition and application thereof, and relates to the technical field of cosmetics. The sialic acid mild brushing acid composition comprises sialic acid and a solvent, the mass concentration of the sialic acid is 2%-15%, and the solvent is selected from at least one of 1, 3-propylene glycol, butanediol, dipropylene glycol and water. The sialic acid is creatively used as one of the mild brushing acid components, can soften old and waste cutin mildly and promote cutin exfoliation and permeation and absorption of the sialic acid, so that the sialic acid can fully play a skin protection role, has an excellent mild cutin exfoliation effect and has the effects of improving hyperpigmentation and coarse pores; and a dynamic balance skin care strategy of breaking while standing and breaking while standing can be realized. The prepared cosmetics have better moisture retention and safety, repair barriers through moisture retention, improve pigmentation through oxidation resistance, stimulate collagen to remodel a supporting structure to improve coarse pores, and finally consolidate the health state of the skin through immunoregulation.

The invention provides formulations for treating hair loss, methods of treatment for hair loss, and cosmetic methods for reducing hair loss or stimulating hair growth or regrowth. An exemplary formulation for treating hair loss includes: one or more of wedelolactone, demethylwedelolactone, and demethylwedelolactone glucoside; ß-sitosterol; and one or more of thymoquinone, thymohydroquinone, dithymoquinone and thymol.

The invention relates to a composition for resisting and repairing light damage and application of the composition in skin care, and belongs to the technical field of cosmetics. According to the composition, the problem of light damage is solved from multiple dimensions for the first time, the composition comprises the lactobacillus / grape juice extract, the tetrahydromethylpyrimidine carboxylic acid, the glucosyl hesperidin, the adenosine and the eryngium maritimum callus culture filtrate, and all the active ingredients supplement one another and have a synergistic effect, so that the composition can resist the light damage, and meanwhile, the effect of resisting the light damage is achieved. The composition has the advantages of being capable of improving the skin repair capacity, improving the pigmentation problem caused by light injury, strengthening the skin barrier, effectively resisting external infringement and providing a mild solution for people suffering from sensitive skin and light injury troubles.

The present application provides a kind of application of the steroid compound in preparation prevention or treatment skin pigmentation related condition or anti-aging related product, the steroid compound is as shown in formula I, and has treatment, lightening and / or alleviating effect on senile plaques, freckles, chloasma and the like caused by pigmentation on the skin of mammal.(I).

The present disclosure relates to systems and methods for quantifying hypo- or hyper-skin pigmentation conditions. An example method includes providing an image of a skin surface. The method also includes selecting a plurality of color channels from among a plurality of color models. The method yet also includes forming a color-adjusted version of the image based on the selected combination of color channels. The method additionally includes extracting a mask based on the color-adjusted version of the image. The method yet further includes determining, based on the extracted mask, a normal portion of the skin surface. The method also includes determining, based on the extracted mask, a differently-pigmented portion of the skin surface. The method additionally includes providing information indicative of the differently-pigmented portion of the skin surface.

The invention discloses a preparation for treating psoriasis and application. The preparation is prepared from the following raw materials: propylene glycol, halcinonide, fluocinonide acetate, salicylic acid, dimethyl sulfoxide, polyethylene glycol 400, glycerol, borneol, edetate disodium, ethylparaben and ethylparaben. The traditional Chinese medicine composition is reasonable in composition, the treatment effect on psoriasis can be remarkably improved, the problem of pigmentation after treatment can be effectively improved or avoided, and particularly, due to the use of salicylic acid and edetate disodium, it is verified that the traditional Chinese medicine composition has a remarkable curative effect on psoriasis. Salicylic acid and edetate disodium have a synergistic effect on psoriasis treatment effect and pigmentation improvement of the whole medicine system.

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

Disclosed are pigmented multifunctional barrier coating compositions for application to components such as aircraft interior components. In embodiments, compositions include a base coating component in an amount from 5 to 40 weight percent of the composition, a solvent in an amount from 50 to 70 weight percent of the composition, and at least two performance components from an FST-resistive component in an amount from 0.1 to 5 weight percent of the composition, a UV-resistive component in an amount from 0.1 to 2 weight percent of the composition, an antimicrobial component in an amount from 0.1 to 5 weight percent of the composition, and a dye component in an amount less than 0.5 weight percent of the composition. The composition further includes pigment in an amount up to 10 weight percent of the composition for imparting a cosmetic appearance to the component such as a metallic appearance.

This invention relates to a whitening extract from geranium, its preparation method, and its application, belonging to the field of plant extract preparation and cosmetic technology. The extraction method includes: preparing a eutectic solvent by mixing choline chloride and citric acid in a molar ratio of 2:1 to 4:1, and adjusting the water content to 30-70%; mixing geranium raw material powder with the eutectic solvent at a material-liquid ratio of 1:5-15 (g / mL), and performing ultrasonic-assisted extraction; concentrating the extract under reduced pressure and then freeze-drying to obtain a geranium whitening extract with a total flavonoid content of 1-4 mg / g, a total polyphenol content of 3-6 mg / g, and anthocyanin content of 1-3 mg / g. This extract can be used to prepare cosmetics or topical skin preparations with whitening, brightening, antioxidant, or pigmentation-improving effects, as well as a tyrosinase activity inhibitor. This invention provides a green and efficient method for extracting the whitening active ingredients from geranium.

Disclosed are a composition and a formulation. The composition comprises tranexamic acid and a tretinoin alcohol amine or tretinoin fatty amine compound. After the composition is prepared into the formulation, the solubility of tretinoin can be improved, the loss of tretinoin in the formulation process is reduced, the content uniformity of the formulation is improved, and the stability of the formulation is improved. The composition can significantly increase the intradermal retention amount of tretinoin and tranexamic acid, and meanwhile, the cross-skin permeation amount of tranexamic acid is not significantly increased. In the treatment of pigmentation and chloasma, the composition and the formulation can significantly improve the curative effect and avoid aggravating toxic and side effects.

The present disclosure relates to methods for the treatment, amelioration, or prophylaxis of an inflammatory and / or an autoimmune disease or disorder or a disease or disorder related thereto (e.g., wounds, pigmentation or pigmentation related diseases and disorders, joint or joint related diseases and disorders, respiratory or respiratory related diseases or disorders; and fibrosis or fibrosis associated diseases and disorders) using soft BET inhibitors.

The present invention provides a method for calculating the age of the eye area, the method comprising the steps in which: (a) an eye area image extraction unit (310) extracts an eye area image from a face image including the eye area of an evaluation target; (b) a calculation unit (320) calculates wrinkle information, pigmentation information, and elasticity information from the eye area image using a preset method; and (c) an eye area age calculation unit (330) calculates the age of the eye area by inputting at least one of the wrinkle information, pigmentation information, or elasticity information into a pre-generated linear regression model.

The present application relates to a kind of skin grafting materials and its preparation and use method, which is composed of carrier sheet, anvil sheet and repair liquid, without skin adhesive;When using, cut skin dermis layer is attached to anvil sheet, put into medical leather rolling machine, and cut into microskin grafting;Spray repair liquid on the cut microskin grafting, transfer to carrier sheet, paste in the place to be grafted, separate aluminum foil and take down, wrap with gauze.The skin grafting material provided by the present application can reduce the damage to new granulation when removing skin grafting material, has the effects of antibacterial and anti-inflammatory, promoting repair and healing, promoting cell proliferation, providing scaffold for cell crawling, hemostasis, absorbing exudate, reducing scar formation and pigmentation, etc., can effectively accelerate epithelialization in skin grafting area;The effect after recovery is good, can be used for burn and scald, mechanical trauma, diabetic foot and other wounds, and has wide application prospect.

The peptide of the present invention inhibits melanosome sinking in keratinocytes and promotes melanosome degradation, thereby having a skin whitening activity. The peptide of the present invention can be used as an active ingredient of a drug for treating or preventing hyperpigmentation diseases caused by melanin hyperpigmentation, or as an active ingredient of a skin whitening cosmetic.

According to the dermatosis medicine based on xanthoxylin WGX-50 and the preparation method thereof, WGX-50 has a strong anti-oxidation characteristic and is crucial to the anti-aging process of skin, and meanwhile, it is found that WGX-50 has the effects of promoting regeneration of collagen, elastin and lipid droplets, inhibiting expression of key genes participating in melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis and inhibiting melanogenesis. Due to the characteristics, the WGX-50 can effectively repair skin injury related to the natural aging process, and meanwhile, the WGX-50 has remarkable whitening and antioxidant effects. Compared with the effect of an asiaticoside cream ointment, the WGX-50 is effective on chloasma by reducing skin pigmentation, the effect of the WGX-50 is better than that of asiaticoside, and in the treatment of chloasma, the WGX-50 can be used as another method for relieving pigmentation and improving skin quality.

The invention provides a skin repair composition, a skin repair product and application of the skin repair composition and the skin repair product. The skin repair composition comprises the polydeoxyribonucleotide and the salt thereof, the Ectoine or the derivative thereof and the schizophyllan, overcomes the defect of single function of bioactive substances, and has the effects of inhibiting expression of inflammatory factors and accelerating repair of damaged skin pigmentation. The three active ingredients in the skin repair composition are not simply superposed, but generate a synergistic gain effect of '1 + 1 + 1gt, 3', the safety and effectiveness are obviously superior to those in the prior art, and a brand-new and excellent solution is provided for solving the problems of light and moderate acne of teenagers and hyperpigmentation after healing.

This invention discloses a whitening and repairing composition suitable for sensitive skin and its application, belonging to the field of cosmetic technology. The composition uses white chamomile flower extract, mimosa flower extract, and hibiscus flower extract as its main active ingredients. These three ingredients work synergistically: white chamomile flower extract provides soothing, anti-allergic, anti-oxidative, anti-aging, and whitening effects; mimosa flower extract combats glycation and repairs circadian rhythms; and hibiscus flower extract offers powerful antioxidant effects and delays aging. This composition inhibits melanin production at its source, reducing pigmentation caused by external stimuli. Simultaneously, the soothing and anti-inflammatory properties of the three ingredients lower the risk of irritation and sensitization during the whitening process, making it suitable for the whitening and repairing needs of people with sensitive skin.

Devices and methods for applying makeup to skin are generally provided. In some embodiments, the devices and methods disclosed herein may be used to apply makeup to skin in a pattern that mimics a natural arrangement of freckles or other pigment irregularities of the skin. In some embodiments, the appearance of pigment irregularities such as those that mimic naturally occurring arrangements of freckles may be desirable, based on the aesthetic preferences of a user. Advantageously, the devices and methods disclosed herein may allow for the application of makeup to the skin in a pattern that looks similar to (e.g., mimics) naturally occurring arrangements of freckles. Without wishing to be bound by a particular theory, it is believed that several features of the disclosed devices (e.g., variations in the height and / or spacing of protrusions configured to mimic an arrangement of freckles, as described in greater detail below) may accurately mimic the variations in size and spacing found in naturally occurring arrangements of freckles. The methods as described herein may also allow for a user to control the level of pigmentation, shape, and / or spacing of deposits of makeup transferred to the skin, which is believed to also allow for the accurate mimicking of variations of size, shape, and pigmentation levels in naturally occurring arrangements of freckles.

The invention provides a repairing composition containing PN and sodium hyaluronate as well as a preparation method and application of the repairing composition, and relates to the technical fields of medicines, medical instruments and cosmetics. The repairing composition is prepared from the following components in parts by weight: 1 to 4 parts of PN, 30 to 60 parts of sodium hyaluronate, 3 to 8 parts of palmitoyl tripeptide-5, 2.5 to 5 parts of radix notoginseng extract, 0.5 to 2 parts of radix astragali seu hedysari extract, 0.5 to 2 parts of recombinant human epidermal growth factor and 0.5 to 2 parts of calendula extract. The pseudo-ginseng extract is subjected to heating treatment by adopting an alkaline substance, so that dissolution of active ingredients is facilitated; the astragalus extract is subjected to decoction and microwave-assisted treatment, so that the content of astragalus polysaccharide and other components is increased; all the components interact with one another, so that the effects of remarkably promoting wound healing, resisting inflammation and improving skin acne pigmentation are achieved.

Device: The invention aims to treat skin imperfections (spots, angiomas, freckles, marks, spots, discolorations, stretch marks, scars, etc.), to erase them, and to diminish their appearance. More and more people are experiencing problems with skin imperfections (spots, angiomas, freckles, marks, spots, discolorations, stretch marks, scars, etc.), and are particularly sensitive to what they consider a problem. This constitutes a real societal phenomenon. Many people are distressed by these visual aspects of their skin. It is therefore necessary to make these features invisible or less visible. The proposed technical solution is to use colored inks to create a skin tone match and to tattoo the area to be treated with this ink. [Fig. 1] A specific needle [Fig. 2] can be used for this procedure.

The present invention relates to a process for preparing N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-butanamide. The present invention further relates to a pharmaceutical formulation and the use of said pharmaceutical formulation consisting of N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-butanamide or pharmaceutically acceptable salts thereof as active compound for the treatment and prevention of autoimmune diseases and diseases involving skin immunology, skin autoimmune diseases and pigmentation disorders.