86 results about "Pigmentations" patented technology

The utility model belongs to the technical field of medical instruments, and particularly relates to a cooling and analgesia device capable of being folded in a partitioned mode in a laser therapy operation, which is mainly used for cold compress of the face of a patient in the laser therapy operation. The device mainly comprises a flexible substrate which is provided with a hollow area; at least one side of each cold compress unit is connected with the flexible base layer, and the cold compress units are all located in the hollow area, so that the hollow area is covered with the cold compress units; wherein the cold compress unit is constructed to be capable of being folded relative to the flexible base layer, so that a part of the hollow area is exposed; the face cold compress device has the advantages that face cold compress is conducted on a patient in real time in an operation, so that the pain of the patient is relieved, and postoperative vesicles and hyperpigmentation are prevented.

The invention provides an enhanced transdermal delivery beauty patch containing efficient active PDRN (DNA sodium) and a preparation method thereof, the enhanced transdermal delivery beauty patch is composed of a needle body layer and a backing layer, the needle body layer comprises the following components by mass: 5-15% of PDRN with a molecular weight of 50-300 kDa, 10-20% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight The content of the zwitterionic polymer carrier is 30%-50%, and the zwitterionic polymer carrier is formed by copolymerizing methacryloylethyl sulfobetaine and hyaluronic acid. The composition has the characteristics of good mechanical properties, rapid dissolution, high activity retention and efficient permeation promotion, can be used for treatment of pigmentation after acne and skin barrier repair, and comprehensively improves the skin repair effect and practicability.

The invention discloses a sialic acid mild brushing acid composition and application thereof, and relates to the technical field of cosmetics. The sialic acid mild brushing acid composition comprises sialic acid and a solvent, the mass concentration of the sialic acid is 2%-15%, and the solvent is selected from at least one of 1, 3-propylene glycol, butanediol, dipropylene glycol and water. The sialic acid is creatively used as one of the mild brushing acid components, can soften old and waste cutin mildly and promote cutin exfoliation and permeation and absorption of the sialic acid, so that the sialic acid can fully play a skin protection role, has an excellent mild cutin exfoliation effect and has the effects of improving hyperpigmentation and coarse pores; and a dynamic balance skin care strategy of breaking while standing and breaking while standing can be realized. The prepared cosmetics have better moisture retention and safety, repair barriers through moisture retention, improve pigmentation through oxidation resistance, stimulate collagen to remodel a supporting structure to improve coarse pores, and finally consolidate the health state of the skin through immunoregulation.

The present application provides a kind of application of the steroid compound in preparation prevention or treatment skin pigmentation related condition or anti-aging related product, the steroid compound is as shown in formula I, and has treatment, lightening and / or alleviating effect on senile plaques, freckles, chloasma and the like caused by pigmentation on the skin of mammal.(I).

The present disclosure relates to systems and methods for quantifying hypo- or hyper-skin pigmentation conditions. An example method includes providing an image of a skin surface. The method also includes selecting a plurality of color channels from among a plurality of color models. The method yet also includes forming a color-adjusted version of the image based on the selected combination of color channels. The method additionally includes extracting a mask based on the color-adjusted version of the image. The method yet further includes determining, based on the extracted mask, a normal portion of the skin surface. The method also includes determining, based on the extracted mask, a differently-pigmented portion of the skin surface. The method additionally includes providing information indicative of the differently-pigmented portion of the skin surface.

The invention discloses a preparation for treating psoriasis and application. The preparation is prepared from the following raw materials: propylene glycol, halcinonide, fluocinonide acetate, salicylic acid, dimethyl sulfoxide, polyethylene glycol 400, glycerol, borneol, edetate disodium, ethylparaben and ethylparaben. The traditional Chinese medicine composition is reasonable in composition, the treatment effect on psoriasis can be remarkably improved, the problem of pigmentation after treatment can be effectively improved or avoided, and particularly, due to the use of salicylic acid and edetate disodium, it is verified that the traditional Chinese medicine composition has a remarkable curative effect on psoriasis. Salicylic acid and edetate disodium have a synergistic effect on psoriasis treatment effect and pigmentation improvement of the whole medicine system.

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

This invention relates to a whitening extract from geranium, its preparation method, and its application, belonging to the field of plant extract preparation and cosmetic technology. The extraction method includes: preparing a eutectic solvent by mixing choline chloride and citric acid in a molar ratio of 2:1 to 4:1, and adjusting the water content to 30-70%; mixing geranium raw material powder with the eutectic solvent at a material-liquid ratio of 1:5-15 (g / mL), and performing ultrasonic-assisted extraction; concentrating the extract under reduced pressure and then freeze-drying to obtain a geranium whitening extract with a total flavonoid content of 1-4 mg / g, a total polyphenol content of 3-6 mg / g, and anthocyanin content of 1-3 mg / g. This extract can be used to prepare cosmetics or topical skin preparations with whitening, brightening, antioxidant, or pigmentation-improving effects, as well as a tyrosinase activity inhibitor. This invention provides a green and efficient method for extracting the whitening active ingredients from geranium.

The present disclosure relates to methods for the treatment, amelioration, or prophylaxis of an inflammatory and / or an autoimmune disease or disorder or a disease or disorder related thereto (e.g., wounds, pigmentation or pigmentation related diseases and disorders, joint or joint related diseases and disorders, respiratory or respiratory related diseases or disorders; and fibrosis or fibrosis associated diseases and disorders) using soft BET inhibitors.

The present invention provides a method for calculating the age of the eye area, the method comprising the steps in which: (a) an eye area image extraction unit (310) extracts an eye area image from a face image including the eye area of an evaluation target; (b) a calculation unit (320) calculates wrinkle information, pigmentation information, and elasticity information from the eye area image using a preset method; and (c) an eye area age calculation unit (330) calculates the age of the eye area by inputting at least one of the wrinkle information, pigmentation information, or elasticity information into a pre-generated linear regression model.

The present application relates to a kind of skin grafting materials and its preparation and use method, which is composed of carrier sheet, anvil sheet and repair liquid, without skin adhesive;When using, cut skin dermis layer is attached to anvil sheet, put into medical leather rolling machine, and cut into microskin grafting;Spray repair liquid on the cut microskin grafting, transfer to carrier sheet, paste in the place to be grafted, separate aluminum foil and take down, wrap with gauze.The skin grafting material provided by the present application can reduce the damage to new granulation when removing skin grafting material, has the effects of antibacterial and anti-inflammatory, promoting repair and healing, promoting cell proliferation, providing scaffold for cell crawling, hemostasis, absorbing exudate, reducing scar formation and pigmentation, etc., can effectively accelerate epithelialization in skin grafting area;The effect after recovery is good, can be used for burn and scald, mechanical trauma, diabetic foot and other wounds, and has wide application prospect.

According to the dermatosis medicine based on xanthoxylin WGX-50 and the preparation method thereof, WGX-50 has a strong anti-oxidation characteristic and is crucial to the anti-aging process of skin, and meanwhile, it is found that WGX-50 has the effects of promoting regeneration of collagen, elastin and lipid droplets, inhibiting expression of key genes participating in melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis, inhibiting melanogenesis and inhibiting melanogenesis. Due to the characteristics, the WGX-50 can effectively repair skin injury related to the natural aging process, and meanwhile, the WGX-50 has remarkable whitening and antioxidant effects. Compared with the effect of an asiaticoside cream ointment, the WGX-50 is effective on chloasma by reducing skin pigmentation, the effect of the WGX-50 is better than that of asiaticoside, and in the treatment of chloasma, the WGX-50 can be used as another method for relieving pigmentation and improving skin quality.

The invention provides a skin repair composition, a skin repair product and application of the skin repair composition and the skin repair product. The skin repair composition comprises the polydeoxyribonucleotide and the salt thereof, the Ectoine or the derivative thereof and the schizophyllan, overcomes the defect of single function of bioactive substances, and has the effects of inhibiting expression of inflammatory factors and accelerating repair of damaged skin pigmentation. The three active ingredients in the skin repair composition are not simply superposed, but generate a synergistic gain effect of '1 + 1 + 1gt, 3', the safety and effectiveness are obviously superior to those in the prior art, and a brand-new and excellent solution is provided for solving the problems of light and moderate acne of teenagers and hyperpigmentation after healing.

This invention discloses a whitening and repairing composition suitable for sensitive skin and its application, belonging to the field of cosmetic technology. The composition uses white chamomile flower extract, mimosa flower extract, and hibiscus flower extract as its main active ingredients. These three ingredients work synergistically: white chamomile flower extract provides soothing, anti-allergic, anti-oxidative, anti-aging, and whitening effects; mimosa flower extract combats glycation and repairs circadian rhythms; and hibiscus flower extract offers powerful antioxidant effects and delays aging. This composition inhibits melanin production at its source, reducing pigmentation caused by external stimuli. Simultaneously, the soothing and anti-inflammatory properties of the three ingredients lower the risk of irritation and sensitization during the whitening process, making it suitable for the whitening and repairing needs of people with sensitive skin.

Devices and methods for applying makeup to skin are generally provided. In some embodiments, the devices and methods disclosed herein may be used to apply makeup to skin in a pattern that mimics a natural arrangement of freckles or other pigment irregularities of the skin. In some embodiments, the appearance of pigment irregularities such as those that mimic naturally occurring arrangements of freckles may be desirable, based on the aesthetic preferences of a user. Advantageously, the devices and methods disclosed herein may allow for the application of makeup to the skin in a pattern that looks similar to (e.g., mimics) naturally occurring arrangements of freckles. Without wishing to be bound by a particular theory, it is believed that several features of the disclosed devices (e.g., variations in the height and / or spacing of protrusions configured to mimic an arrangement of freckles, as described in greater detail below) may accurately mimic the variations in size and spacing found in naturally occurring arrangements of freckles. The methods as described herein may also allow for a user to control the level of pigmentation, shape, and / or spacing of deposits of makeup transferred to the skin, which is believed to also allow for the accurate mimicking of variations of size, shape, and pigmentation levels in naturally occurring arrangements of freckles.

Device: The invention aims to treat skin imperfections (spots, angiomas, freckles, marks, spots, discolorations, stretch marks, scars, etc.), to erase them, and to diminish their appearance. More and more people are experiencing problems with skin imperfections (spots, angiomas, freckles, marks, spots, discolorations, stretch marks, scars, etc.), and are particularly sensitive to what they consider a problem. This constitutes a real societal phenomenon. Many people are distressed by these visual aspects of their skin. It is therefore necessary to make these features invisible or less visible. The proposed technical solution is to use colored inks to create a skin tone match and to tattoo the area to be treated with this ink. [Fig. 1] A specific needle [Fig. 2] can be used for this procedure.

The present invention relates to a process for preparing N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-butanamide. The present invention further relates to a pharmaceutical formulation and the use of said pharmaceutical formulation consisting of N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-butanamide or pharmaceutically acceptable salts thereof as active compound for the treatment and prevention of autoimmune diseases and diseases involving skin immunology, skin autoimmune diseases and pigmentation disorders.

The invention relates to the technical field of cosmetics, in particular to a mark fading and repairing composition as well as a preparation method and application thereof. The invention relates to a mark fading and repairing composition which comprises the following components in percentage by weight: 0.1%-5% of dragon's blood extract, 0.01%-0.5% of keratinase and 1%-5% of nicotinamide, the preparation method comprises the following steps: preparing the eutectic solvent; performing ultrasonic-assisted extraction; separation and post-treatment; the invention has the following beneficial effects: the resina draconis extract can inhibit continuous pigmentation caused by acne inflammation residue, promote healing of skin minimal wounds and reduce dermis layer injury of acne mark parts; keratinase specifically hydrolyzes stratum corneum aged keratin, cutin metabolism of acne mark parts is accelerated, and accumulation of pigments in stratum corneum is avoided; nicotinamide inhibits melanocytes from transferring melanin to keratinocytes; through the synergistic effect of the three components, a closed-loop printing fading mechanism of anti-inflammatory repair-keratin metabolism-pigment inhibition is formed, the printing fading effect is more comprehensive and more efficient, and skin repair and barrier protection can be both considered.

The invention belongs to the technical field of extraction and application of algae polysaccharide, and discloses gracilaria lemaneiformis polysaccharide as well as a preparation method and application thereof. The structural formula of the gracilaria lemaneiformis polysaccharide is as shown in the formula (1). The gracilaria lemaneiformis polysaccharide provided by the invention can promote reduction of cell melanin expression, has a whitening effect, and can be used for preparing medicines or cosmetics for treating / preventing skin photoaging pigmentation. The preparation method provided by the invention is green, safe, pollution-free, simple to operate, economical, time-saving and high in practicability.

The invention discloses composite hydrogel and application thereof in removal of benign hyperpigmentation, and belongs to the field of medical cosmetology. The composite hydrogel comprises perfluorinated carbon or / and semi-fluorinated alkyl and a gel matrix, wherein the weight percentage of the perfluorinated carbon or / and semi-fluorinated alkyl is 1-60% relative to the total weight of the composite hydrogel; the perfluorinated carbon or / and the semi-fluorinated alkane is / are dispersed in the gel matrix in a liquid drop form; in the liquid drops, the ratio of the number of the liquid drop particles with the diameter larger than 100 microns to the number of the liquid drop particles with the diameter of 1-100 microns is not higher than 0.1. When the composite hydrogel is used for assisting light therapy, especially for assisting laser in removing benign pigmentation, besides providing light-guiding and heat-conducting properties, the composite hydrogel also has gas-dissolving and anti-inflammatory properties, can effectively accelerate healing or relieve uncomfortable symptoms such as burning, pain, skin redness and swelling, inflammation and skin whitening of patients, enhances the visibility of light spots, and has a good application prospect. The safety of laser treatment is improved, the defects in current clinical application are overcome, and the laser treatment device has extremely high clinical application value.

The present invention provides a composition comprising 5-aminolevulinic acid or a salt or ester thereof, comprising: (a) an active ingredient selected from 5-aminolevulinic acid or a salt or ester thereof; and (b) an aqueous carrier comprising an analgesic. The 5-aminolevulinic acid or the salt or ester thereof can be used for photodynamic therapy analgesia for more than 20 minutes, so that the clinical treatment cycle can be covered, the pain feeling after photodynamic therapy can be obviously relieved, the photodynamic therapy receiving time of a patient is prolonged, and the medication compliance of the patient is improved. Moreover, the composition provided by the invention can also improve the condition of tissue edema after photodynamic therapy, improve the skin smoothness after photodynamic therapy and shorten the pigmentation time, and meanwhile, compared with a marketed preparation, the composition has a better effect in the aspect of photodynamic therapy of inflammatory diseases (such as psoriasis or contact dermatitis) or acne and the like, and has a good application prospect. The acceptability of the patient to the photodynamic therapy is further improved; and the application scene of the photodynamic therapy is widened.

The invention relates to the field of eye cosmetics, in particular to a composition with anti-aging and whitening effects, a preparation method of the composition and the eye cosmetics. The composition is prepared from the following components in percentage by mass: 0.1-5% of a first active component, i.e., a curcuma zedoaria root extract; 0.1 to 5% of nicotinamide; 0.1 to 5% of acetylchitosamine; a 1%-30% acetyl ring (glutaryl hexapeptide-121) tetrapeptide-142 amide solution is prepared; a 0.1 to 5% acetyl tetrapeptide-5 solution; 0.1-2% of a yeast / rice fermentation product solution; 0.01 to 1 percent of heparin sodium; 1%-5% of 1, 2-pentanediol and the balance of water; through cooperation of multiple channels of inhibiting neural signals, promoting collagen, blocking melanin transfer, improving microcirculation and repairing skin barriers, the eye mask has an instant and long-acting anti-aging effect, has the effects of whitening, fading dark circles and relieving under-eye puffiness, and can effectively solve the problems of wrinkles, looseness, dark circles, under-eye puffiness and hyperpigmentation of eyes.

The embodiment of the invention provides a cosmetic composition capable of instantly brightening skin color and application of the cosmetic composition. The cosmetic composition comprises the following components in percentage by weight: 10-25% of glycerol; 1-5% of fructose; 0.1 to 1% of maltose; 0.1 to 1% of trehalose; 0.1 to 1% of allantoin; 0.01 to 0.1 percent of glucose; 0.1 to 1 percent of p-hydroxyacetophenone; based on the total weight of the cosmetic composition. The cosmetic composition provided by the embodiment of the invention not only can provide anti-oxidation and cell protection effects and reduce oxidative stress induced pigmentation, but also can regulate interaction between light and skin and reduce light scattering on the surface of the skin, so that the cosmetic composition has the effects of instantly brightening the skin and improving the glossiness and whiteness of the skin.

The present application provides a kind of safe setting powder and its preparation method, the setting powder includes the following mass parts of raw materials: hollow glass beads 20-35 parts, kaolin 6-10 parts, calcium carbonate 3-10 parts, magnesium carbonate 12-15 parts, zinc oxide 12-15 parts, titanium white 10-15 parts, metal soap 6-9 parts, perfume 0.1-0.3 parts, pigment 0.1-0.3 parts.The above-mentioned setting powder is prepared by first grinding and mixing other raw materials except hollow glass beads, then adding floating hollow glass beads for mixing.The above-mentioned safe setting powder uses hollow glass beads instead of talc in the existing setting powder, and has better lubricity, so the setting powder not only reduces the risk of carcinogenesis to human body and has high safety, but also has longer makeup holding effect, even in high temperature or exercise and other hyperhidrosis state, the pigmentation value retention rate is not less than 80%, can guarantee to keep 8 hours without falling off, and has high makeup holding stability.

The present invention relates to a method for determining UV protection efficacy of functional cosmetics on the basis of AI and, particularly, to a UV protection efficacy determination method comprising: applying functional cosmetics to a subject's skin; subsequently irradiating the skin with UV light; and determining protection efficacy by observing changes in the skin, wherein the observing of the changes in the skin irradiated with UV light is performed through detection of erythema or pigment darkening by an artificial intelligence algorithm from an image obtained by capturing the subject's skin; and the artificial intelligence algorithm performs the detection of erythema or pigment darkening by applying skin tone information calculated from an image obtained by capturing the subject's skin not irradiated with UV light. According to the present invention, UV protection efficacy is determined using artificial intelligence, so that the determination of the UV protection efficacy is objectified, and the reliability of determination results increases. In addition, since the determination process is automated by artificial intelligence, time required for determination can be reduced.

The peptide of the present application has a skin-whitening activity by inhibiting incorporation of melanin into keratinocytes and promoting degradation of melanin. The peptide of the present application can be used as an active ingredient in a medicament for treating or preventing a hyperpigmentation disease caused by excessive deposition of melanin, or as an active ingredient in a cosmetic for skin whitening.

The application discloses a Leuconostoc strain and application thereof, and the Leuconostoc strain HX-236 is screened by the inventors. The Leuconostoc strain HX-236 uses cordyceps militaris powder as the only nitrogen source, and after fermentation culture, a fermentation filtrate can be obtained. The fermentation filtrate has high contents of cordycepin and cordycepic acid, is easily soluble in water, is convenient to use, has good stability, has good compatibility, can significantly improve the expression of hypoxia inducible factor (HIF-1 alpha) in cells, thereby activating downstream signal pathways for regulating inflammatory reactions, cell autophagy and tissue neogenesis, and then regulating cell hypoxia pressure, improving problems of skin aging such as cell activity reduction, collagen loss, pigmentation and skin elasticity reduction caused by hypoxia, and having wide application prospects in the fields of medicines, cosmetics and the like.

The invention belongs to the technical field, and particularly relates to a plant extract composition with a whitening effect and a preparation method thereof. The composition provided by the invention takes natural plants and bioactive components as cores, avoids the use of chemical whitening agents with potential toxicity, such as hydroquinone, mercury salt and the like, and is high in safety and low in irritation. All the components cooperate with one another in a reasonable proportion, so that melanin generation can be inhibited from the source, and metabolism of generated melanin can be promoted; according to the present invention, the whitening effect is improved, the multiple skin care functions such as moisturizing, anti-aging, repairing and the like are further considered, and the mask is suitable for various skin types, and is especially suitable for people with dark skin color, hyperpigmentation, dryness, water shortage and mild sensitive skin.

The invention relates to the technical field of skin care products, and particularly discloses a composition for improving the skin state of pressure muscles as well as a preparation method and application of the composition. According to the application, the composition for improving the skin state of the pressure muscle is formed by the combined action of the guaiazulene flexible body, the tephrosia rubescens seed extract, the nicotinamide and the camellia exosome; the guaiazulene flexible body and the tephrosia rubescens seed extract can jointly inhibit a TRPV1 / P substance pathway to relieve neurogenic causalgia, the nicotinamide and the camellia exosome can block alpha-MSH mediated hyperpigmentation and repair a barrier to reduce TEWL, and meanwhile, the four components can activate collagen regeneration and resist external stimulation; neural calming, black fading, barrier repairing and anti-aging are synchronously realized, and HPA axis cascade injury is blocked, so that repeated deterioration of symptoms is avoided.