55 results about "Pigmentations" patented technology

The present application provides a kind of application of the steroid compound in preparation prevention or treatment skin pigmentation related condition or anti-aging related product, the steroid compound is as shown in formula I, and has treatment, lightening and / or alleviating effect on senile plaques, freckles, chloasma and the like caused by pigmentation on the skin of mammal.(I).

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

This invention relates to a whitening extract from geranium, its preparation method, and its application, belonging to the field of plant extract preparation and cosmetic technology. The extraction method includes: preparing a eutectic solvent by mixing choline chloride and citric acid in a molar ratio of 2:1 to 4:1, and adjusting the water content to 30-70%; mixing geranium raw material powder with the eutectic solvent at a material-liquid ratio of 1:5-15 (g / mL), and performing ultrasonic-assisted extraction; concentrating the extract under reduced pressure and then freeze-drying to obtain a geranium whitening extract with a total flavonoid content of 1-4 mg / g, a total polyphenol content of 3-6 mg / g, and anthocyanin content of 1-3 mg / g. This extract can be used to prepare cosmetics or topical skin preparations with whitening, brightening, antioxidant, or pigmentation-improving effects, as well as a tyrosinase activity inhibitor. This invention provides a green and efficient method for extracting the whitening active ingredients from geranium.

The present invention provides a method for calculating the age of the eye area, the method comprising the steps in which: (a) an eye area image extraction unit (310) extracts an eye area image from a face image including the eye area of an evaluation target; (b) a calculation unit (320) calculates wrinkle information, pigmentation information, and elasticity information from the eye area image using a preset method; and (c) an eye area age calculation unit (330) calculates the age of the eye area by inputting at least one of the wrinkle information, pigmentation information, or elasticity information into a pre-generated linear regression model.

The present application relates to a kind of skin grafting materials and its preparation and use method, which is composed of carrier sheet, anvil sheet and repair liquid, without skin adhesive;When using, cut skin dermis layer is attached to anvil sheet, put into medical leather rolling machine, and cut into microskin grafting;Spray repair liquid on the cut microskin grafting, transfer to carrier sheet, paste in the place to be grafted, separate aluminum foil and take down, wrap with gauze.The skin grafting material provided by the present application can reduce the damage to new granulation when removing skin grafting material, has the effects of antibacterial and anti-inflammatory, promoting repair and healing, promoting cell proliferation, providing scaffold for cell crawling, hemostasis, absorbing exudate, reducing scar formation and pigmentation, etc., can effectively accelerate epithelialization in skin grafting area;The effect after recovery is good, can be used for burn and scald, mechanical trauma, diabetic foot and other wounds, and has wide application prospect.

The invention provides a skin repair composition, a skin repair product and application of the skin repair composition and the skin repair product. The skin repair composition comprises the polydeoxyribonucleotide and the salt thereof, the Ectoine or the derivative thereof and the schizophyllan, overcomes the defect of single function of bioactive substances, and has the effects of inhibiting expression of inflammatory factors and accelerating repair of damaged skin pigmentation. The three active ingredients in the skin repair composition are not simply superposed, but generate a synergistic gain effect of '1 + 1 + 1gt, 3', the safety and effectiveness are obviously superior to those in the prior art, and a brand-new and excellent solution is provided for solving the problems of light and moderate acne of teenagers and hyperpigmentation after healing.

This invention discloses a whitening and repairing composition suitable for sensitive skin and its application, belonging to the field of cosmetic technology. The composition uses white chamomile flower extract, mimosa flower extract, and hibiscus flower extract as its main active ingredients. These three ingredients work synergistically: white chamomile flower extract provides soothing, anti-allergic, anti-oxidative, anti-aging, and whitening effects; mimosa flower extract combats glycation and repairs circadian rhythms; and hibiscus flower extract offers powerful antioxidant effects and delays aging. This composition inhibits melanin production at its source, reducing pigmentation caused by external stimuli. Simultaneously, the soothing and anti-inflammatory properties of the three ingredients lower the risk of irritation and sensitization during the whitening process, making it suitable for the whitening and repairing needs of people with sensitive skin.

Devices and methods for applying makeup to skin are generally provided. In some embodiments, the devices and methods disclosed herein may be used to apply makeup to skin in a pattern that mimics a natural arrangement of freckles or other pigment irregularities of the skin. In some embodiments, the appearance of pigment irregularities such as those that mimic naturally occurring arrangements of freckles may be desirable, based on the aesthetic preferences of a user. Advantageously, the devices and methods disclosed herein may allow for the application of makeup to the skin in a pattern that looks similar to (e.g., mimics) naturally occurring arrangements of freckles. Without wishing to be bound by a particular theory, it is believed that several features of the disclosed devices (e.g., variations in the height and / or spacing of protrusions configured to mimic an arrangement of freckles, as described in greater detail below) may accurately mimic the variations in size and spacing found in naturally occurring arrangements of freckles. The methods as described herein may also allow for a user to control the level of pigmentation, shape, and / or spacing of deposits of makeup transferred to the skin, which is believed to also allow for the accurate mimicking of variations of size, shape, and pigmentation levels in naturally occurring arrangements of freckles.

The invention relates to the technical field of cosmetics, in particular to a mark fading and repairing composition as well as a preparation method and application thereof. The invention relates to a mark fading and repairing composition which comprises the following components in percentage by weight: 0.1%-5% of dragon's blood extract, 0.01%-0.5% of keratinase and 1%-5% of nicotinamide, the preparation method comprises the following steps: preparing the eutectic solvent; performing ultrasonic-assisted extraction; separation and post-treatment; the invention has the following beneficial effects: the resina draconis extract can inhibit continuous pigmentation caused by acne inflammation residue, promote healing of skin minimal wounds and reduce dermis layer injury of acne mark parts; keratinase specifically hydrolyzes stratum corneum aged keratin, cutin metabolism of acne mark parts is accelerated, and accumulation of pigments in stratum corneum is avoided; nicotinamide inhibits melanocytes from transferring melanin to keratinocytes; through the synergistic effect of the three components, a closed-loop printing fading mechanism of anti-inflammatory repair-keratin metabolism-pigment inhibition is formed, the printing fading effect is more comprehensive and more efficient, and skin repair and barrier protection can be both considered.

The invention belongs to the technical field of extraction and application of algae polysaccharide, and discloses gracilaria lemaneiformis polysaccharide as well as a preparation method and application thereof. The structural formula of the gracilaria lemaneiformis polysaccharide is as shown in the formula (1). The gracilaria lemaneiformis polysaccharide provided by the invention can promote reduction of cell melanin expression, has a whitening effect, and can be used for preparing medicines or cosmetics for treating / preventing skin photoaging pigmentation. The preparation method provided by the invention is green, safe, pollution-free, simple to operate, economical, time-saving and high in practicability.

The present invention provides a composition comprising 5-aminolevulinic acid or a salt or ester thereof, comprising: (a) an active ingredient selected from 5-aminolevulinic acid or a salt or ester thereof; and (b) an aqueous carrier comprising an analgesic. The 5-aminolevulinic acid or the salt or ester thereof can be used for photodynamic therapy analgesia for more than 20 minutes, so that the clinical treatment cycle can be covered, the pain feeling after photodynamic therapy can be obviously relieved, the photodynamic therapy receiving time of a patient is prolonged, and the medication compliance of the patient is improved. Moreover, the composition provided by the invention can also improve the condition of tissue edema after photodynamic therapy, improve the skin smoothness after photodynamic therapy and shorten the pigmentation time, and meanwhile, compared with a marketed preparation, the composition has a better effect in the aspect of photodynamic therapy of inflammatory diseases (such as psoriasis or contact dermatitis) or acne and the like, and has a good application prospect. The acceptability of the patient to the photodynamic therapy is further improved; and the application scene of the photodynamic therapy is widened.

The invention relates to the field of eye cosmetics, in particular to a composition with anti-aging and whitening effects, a preparation method of the composition and the eye cosmetics. The composition is prepared from the following components in percentage by mass: 0.1-5% of a first active component, i.e., a curcuma zedoaria root extract; 0.1 to 5% of nicotinamide; 0.1 to 5% of acetylchitosamine; a 1%-30% acetyl ring (glutaryl hexapeptide-121) tetrapeptide-142 amide solution is prepared; a 0.1 to 5% acetyl tetrapeptide-5 solution; 0.1-2% of a yeast / rice fermentation product solution; 0.01 to 1 percent of heparin sodium; 1%-5% of 1, 2-pentanediol and the balance of water; through cooperation of multiple channels of inhibiting neural signals, promoting collagen, blocking melanin transfer, improving microcirculation and repairing skin barriers, the eye mask has an instant and long-acting anti-aging effect, has the effects of whitening, fading dark circles and relieving under-eye puffiness, and can effectively solve the problems of wrinkles, looseness, dark circles, under-eye puffiness and hyperpigmentation of eyes.

The present application provides a kind of safe setting powder and its preparation method, the setting powder includes the following mass parts of raw materials: hollow glass beads 20-35 parts, kaolin 6-10 parts, calcium carbonate 3-10 parts, magnesium carbonate 12-15 parts, zinc oxide 12-15 parts, titanium white 10-15 parts, metal soap 6-9 parts, perfume 0.1-0.3 parts, pigment 0.1-0.3 parts.The above-mentioned setting powder is prepared by first grinding and mixing other raw materials except hollow glass beads, then adding floating hollow glass beads for mixing.The above-mentioned safe setting powder uses hollow glass beads instead of talc in the existing setting powder, and has better lubricity, so the setting powder not only reduces the risk of carcinogenesis to human body and has high safety, but also has longer makeup holding effect, even in high temperature or exercise and other hyperhidrosis state, the pigmentation value retention rate is not less than 80%, can guarantee to keep 8 hours without falling off, and has high makeup holding stability.

The present invention relates to a method for determining UV protection efficacy of functional cosmetics on the basis of AI and, particularly, to a UV protection efficacy determination method comprising: applying functional cosmetics to a subject's skin; subsequently irradiating the skin with UV light; and determining protection efficacy by observing changes in the skin, wherein the observing of the changes in the skin irradiated with UV light is performed through detection of erythema or pigment darkening by an artificial intelligence algorithm from an image obtained by capturing the subject's skin; and the artificial intelligence algorithm performs the detection of erythema or pigment darkening by applying skin tone information calculated from an image obtained by capturing the subject's skin not irradiated with UV light. According to the present invention, UV protection efficacy is determined using artificial intelligence, so that the determination of the UV protection efficacy is objectified, and the reliability of determination results increases. In addition, since the determination process is automated by artificial intelligence, time required for determination can be reduced.

The peptide of the present application has a skin-whitening activity by inhibiting incorporation of melanin into keratinocytes and promoting degradation of melanin. The peptide of the present application can be used as an active ingredient in a medicament for treating or preventing a hyperpigmentation disease caused by excessive deposition of melanin, or as an active ingredient in a cosmetic for skin whitening.

The application discloses a Leuconostoc strain and application thereof, and the Leuconostoc strain HX-236 is screened by the inventors. The Leuconostoc strain HX-236 uses cordyceps militaris powder as the only nitrogen source, and after fermentation culture, a fermentation filtrate can be obtained. The fermentation filtrate has high contents of cordycepin and cordycepic acid, is easily soluble in water, is convenient to use, has good stability, has good compatibility, can significantly improve the expression of hypoxia inducible factor (HIF-1 alpha) in cells, thereby activating downstream signal pathways for regulating inflammatory reactions, cell autophagy and tissue neogenesis, and then regulating cell hypoxia pressure, improving problems of skin aging such as cell activity reduction, collagen loss, pigmentation and skin elasticity reduction caused by hypoxia, and having wide application prospects in the fields of medicines, cosmetics and the like.

The invention belongs to the technical field, and particularly relates to a plant extract composition with a whitening effect and a preparation method thereof. The composition provided by the invention takes natural plants and bioactive components as cores, avoids the use of chemical whitening agents with potential toxicity, such as hydroquinone, mercury salt and the like, and is high in safety and low in irritation. All the components cooperate with one another in a reasonable proportion, so that melanin generation can be inhibited from the source, and metabolism of generated melanin can be promoted; according to the present invention, the whitening effect is improved, the multiple skin care functions such as moisturizing, anti-aging, repairing and the like are further considered, and the mask is suitable for various skin types, and is especially suitable for people with dark skin color, hyperpigmentation, dryness, water shortage and mild sensitive skin.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

The present application relates to the technical field of biological medicine, in particular to a traditional Chinese medicine composition for improving acne and application, which is made of medicinal raw materials including a first component, a second component and a third component, wherein the first component includes 25-35 parts of white yam, 25-35 parts of hawthorn, 25-35 parts of salvia miltiorrhiza, 13-17 parts of gardenia, and 8-12 parts of white peony; the second component includes 25-35 parts of nacre, 13-17 parts of tribulus terrestris, and 8-12 parts of safflower; and the third component includes 13-17 parts of raw rhubarb, 8-12 parts of gallnut, 8-12 parts of turmeric, 3-7 parts of ganoderma lucidum, and 3-7 parts of winter nightshade. The traditional Chinese medicine composition has the dual effects of inhibiting propionibacterium acnes and anti-inflammation, and especially, the whole composition shows a significant synergistic effect in anti-inflammation in vivo, which is better than each component alone or any two components in combination. The composition can be prepared into oral or external medicines for preventing, relieving and treating various types of acne, and can also improve post-acne pigmentation and post-acne scarring, and has a good application prospect with a significant clinical effect and high safety.

Device: The invention aims to treat skin imperfections (spots, angiomas, freckles, marks, spots, discolorations, stretch marks, scars, etc.), to erase them, and to diminish their appearance. More and more people are experiencing problems with skin imperfections (spots, angiomas, freckles, marks, spots, discolorations, stretch marks, scars, etc.), and are particularly sensitive to what they consider a problem. This constitutes a real societal phenomenon. Many people are distressed by these visual aspects of their skin. It is therefore necessary to make these features invisible or less visible. The proposed technical solution is to use colored inks to create a skin tone match and to tattoo the area to be treated with this ink. [Fig. 1] A specific needle [Fig. 2] can be used for this procedure.

The present invention relates to a process for preparing N-[2-[2-(4-chlorophenyl)-4-thiazolyl] ethyl]-butanamide. The present invention further relates to a pharmaceutical formulation and the use of said pharmaceutical formulation consisting of N-[2-[2-(4-chlorophenyl)-4-thiazolyl] ethyl]-butanamide or pharmaceutically acceptable salts thereof as active compound for the treatment and prevention of autoimmune diseases and diseases involving skin immunology, skin autoimmune diseases and pigmentation disorders.

The application discloses application of an AKT1 inhibitor in preparation of a medicine for treating pigmented villonodular synovitis. A person skilled in the art knows that high migration activity and high invasion activity of PVNS-FLSs are important reasons for causing the development of the disease. Experimental results of the application show that the migration and invasion activity of PVNS-FLSs can be effectively inhibited by silencing AKT1. Therefore, the AKT1 inhibitor has the prospect of being developed into a medicine for treating pigmented villonodular synovitis.

The invention relates to the technical field of gel, in particular to gel based on an intelligent response type dynamic double-membrane hydration system and a preparation method and application of the gel. Tris (hydroxymethyl) aminomethane and carbomer cooperate to form a carbomer-pH-sensitive hydrogel matrix, the swelling degree of the carbomer-pH-sensitive hydrogel matrix is dynamically adjusted along with the change of the pH of a scar microenvironment, and the pH-sensitive hydrogel matrix has the advantages that the stability is high; a static sealing mode of a traditional silicone preparation is broken through, intelligent hydration management of different scar repairing stages (an acute stage and a mature stage) is achieved, an outer silicone isolating membrane formed by polydimethylsiloxane and an inner bioactive lipid membrane formed by composite plant active lipid achieve synergistic interaction, the hydration efficiency is improved by 70% or above, and the application range is wide. The nano transdermal carrier provided by the invention solves the problem of transdermal penetration of silicone and plant active ingredients, and targets to dermal fibroblasts, and clinical data shows that the scar softening rate is improved by more than 40% after the gel is used for 7 days, and the hyperpigmentation improvement rate is improved by more than 50% compared with that of a traditional product.

The invention belongs to the technical field of skin repair and medical skin care products, and discloses application of a blue copper peptide composition in prevention of hyperpigmentation and acceleration of wound healing after a phototherapy microneedle operation. The composition comprises the following active components: blue copper peptide, line particle energy peptide, SnMS protein, nicotinamide and hyaluronic acid, and the components are compounded according to a specific ratio. Through gene reset and system repair, matrix'removal-reconstruction 'biphasic regulation and control, an SIRT1 / STAT3 repair axis is activated, and a multi-target linkage mechanism of multi-channel inhibition of hyperpigmentation is realized, so that high-quality wound healing and hyperpigmentation prevention are realized. The composition has no cytotoxicity, can significantly reduce the ROS content, inhibit the expression of inflammatory factors, and improve the melanin inhibition rate and collagen synthesis amount, solves the problems of single target spot and function fragmentation of the existing postoperative repair product, and upgrades the postoperative care from passive injury repair to active regeneration guidance.

(i) 0.01 to 10% by weight of a branched cationic surfactant selected from the following Structure 1: R1 and R2 are C4 to C 20 R3 contains either a proton or a saturated or unsaturated linear or branched alkyl chain having a carbon-carbon chain length of C1 to C5; n has a range of 0 to 10; X G is an organic or inorganic anion; (ii) 0.1 to 10% by weight of a linear fatty material having at least one linear carbon-carbon chain selected from linear fatty alcohols, linear alkoxylated fatty alcohols, linear fatty acids and mixtures thereof; (iii) 0.1 to 5% by weight of a nonionic structuring agent; and (iv) a particulate benefit agent selected from conditioning actives, wherein the molar ratio of branched cationic surfactant (i) to linear fatty material (ii) is in the range of 1:20 to 1:1. [Formula 1] TIFF2024500809000008.tif23168

The application provides an enhanced transdermal delivery cosmetic patch containing high-efficiency active PDRN (DNA sodium) and a preparation method thereof, which is composed of a needle body layer and a backing layer, wherein the needle body layer contains the following components in percentage by mass: PDRN with a molecular weight of 50-300 kDa, content of 5%-15%; and a zwitterionic polymer carrier copolymerized from methacryloyl ethyl sulfobetaine and hyaluronic acid, content of 30%-50%. The patch has the characteristics of good mechanical properties, rapid dissolution, high active retention and high-efficiency penetration promotion, and can be used for treating post-acne pigmentation and repairing skin barrier, and comprehensively improves the skin repair effect and practicality.

The present application relates to a kind of mRNA delivery system based on liposome with antioxidant efficacy, and functional cosmetic composition containing the system as active ingredient.The mRNA delivery system based on liposome and cosmetic composition of the present application can directly induce the production of antioxidant enzyme in skin cells, thereby providing sustained and effective antioxidant effect.This enables the mRNA delivery system to penetrate into the deep layer of skin, exerting antioxidant effect in epidermis and dermis, thereby enhancing the antioxidant system of skin cells themselves without relying on externally supplied antioxidants.In addition, it can also effectively prevent and improve the problems of skin aging, inflammation, pigmentation and the like caused by oxidative stress, and by applying mRNA technology to the field of cosmetics, it provides an innovative approach to lead a new paradigm for the cosmetic industry.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating acne and an external gel thereof. The traditional Chinese medicine composition is prepared from rheum officinale, cortex phellodendri and radix angelicae according to a specific ratio, specifically, 4 parts of rheum officinale, 1 part of cortex phellodendri and 1 part of radix angelicae (F1) are used for staphylococcus aureus, and 3 parts of rheum officinale, 12 parts of cortex phellodendri and 8 parts of radix angelicae (F2) are used for propionibacterium acnes; the external gel is prepared by taking carbomer 940 as a matrix, adding glycerol, propylene glycol, triethanolamine, Tween-80, potassium sorbate and the like as auxiliary materials and adding the traditional Chinese medicine extract. The composition can be used for treating acne and improving skin inflammation and hyperpigmentation, the gel is convenient to use and stable in property, skin irritation can be reduced, medication safety and patient compliance can be improved, and meanwhile the anti-inflammatory and antibacterial effects are enhanced.

The present invention relates to the cosmetic, nutraceutical use of a strain of Lactobacillus crispatus, in particular that filed under number CNCM I-5579, and / or of a composition comprising it, to reduce pigmentation of the skin and / or mucous membranes and / or prevent its increase, in particular to preserve and / or improve the complexion of the skin and / or mucous membranes, preferably to preserve and / or improve the radiance and / or luminosity and / or homogeneity of the complexion of the skin and / or mucous membranes, and / or to prevent the appearance and / or reduce the presence of pigment spots on the skin and / or mucous membranes and / or detoxify the skin and / or mucous membranes.It also concerns the strain of Lactobacillus crispatus, or a dermatological composition comprising it, for its use, advantageously by topical route, for the treatment and / or prevention of pathologies of the skin and / or mucous membranes associated with an increase in pigmentation of the skin and / or mucous membranes, in particular to depigment and / or prevent hyperpigmentation of pathological skin and / or pathological mucous membranes.