460 results about "Capillary vessels" patented technology

The invention provides a preparation method of medicinal liquor and application of the medicinal liquor in preparation of analgesic and anti-inflammatory products, and relates to the technical field of medicines. The preparation method comprises the following steps: (1) crushing; (2) extracting; (3) standing and separating; and (4) freezing and filtering to obtain the medicinal liquor. In the preparation process, traditional Chinese medicine components are extracted through the steps of batch crushing, mixed extraction, standing, freezing and separation of supernate and suspension in different separation modes to obtain the medicinal liquor, and the medicinal liquor can better inhibit pain caused by thermal stimulation and chemical substances and has a better analgesic effect; the traditional Chinese medicine composition can inhibit capillary permeability increase caused by acetic acid, has a better effect of inhibiting inflammation exudation, and has remarkable analgesic and anti-inflammatory effects.

The invention relates to an adjusting system applied to continuous kidney replacement treatment of acute kidney injury patients. Comprising the following steps: capturing the blood flow velocity and vascular endothelial permeability of glomerular capillaries in real time by using a micro sensor or a nano-scale optical imaging technology; the method comprises the following steps: pre-judging a risk time point of insufficient tissue perfusion through dynamic modeling of a capillary structure and a functional relationship; combining the microcirculation data with conventional biochemical indexes of the patient to create an early intervention model; when it is monitored that microcirculation perfusion is greatly reduced or kidney oxygen supply is insufficient, continuous renal replacement therapy CRRT parameter fine adjustment is triggered in advance; the method comprises the following steps: collecting plasma toxins of different patients at clinical and molecular levels, and constructing a common toxin map of the acute kidney injury AKI; whether the specific toxin concentration exceeds the standard or not is judged by combining a real-time sensor, and the removal priority is output in real time; a membrane material with an adjustable aperture or a special coating is adopted, so that inflammatory mediators and bacterial endotoxin molecules are adsorbed or intercepted, and the permeability of micromolecular electrolyte is kept.

The invention provides a biological blood vessel bionic liquid cooling network heat dissipation method for a humanoid robot, and belongs to the technical field of robot heat dissipation. The biological blood vessel bionic liquid cooling network heat dissipation method for the humanoid robot comprises the following steps: carrying out embedded near-node heat dissipation with a driving source by utilizing a first heat dissipation unit according to the aorta-level local high-heat-flow heat dissipation requirement of a chip located at the brain of the humanoid robot through biological bionic mapping and global partition cascade thermal control; aiming at the high-dynamic multi-heat-source heat dissipation requirement of a joint motor located at a movable joint part of the humanoid robot, indirect heat dissipation with a driving source is carried out by utilizing a second heat dissipation unit; according to the capillary-level low-heat-flux heat dissipation requirement of a power battery located on the chest of the humanoid robot, self-driven indirect heat dissipation is conducted through the capillary pump effect by means of a third heat dissipation unit; and for vein-level liquid cooling backflow, large-area natural convection air cooling heat dissipation on the skin surface is simulated for global heat discharge, and finally the bionic liquid cooling heat dissipation method for the system-level humanoid robot is formed.

The invention relates to the technical field of tumor biomedical engineering and organ chips, in particular to a vascularized gastric cancer organ chip and a preparation method thereof.The chip is composed of an integrated micro-fluidic main body, an annular micro-column array and an optical sealing film, and a central culture cavity is divided into a tumor area and a blood vessel area by micro-columns; the preparation method comprises the following steps: injecting a fibrous protein solution containing human umbilical vein endothelial cells and cancer-related fibroblasts into a vascular region, and adding thrombin for in-situ gelation to form a pre-vascularized network; the method comprises the following steps: mixing a patient-derived gastric cancer organ with a methacrylic acid esterified gelatin pre-polymerized solution, injecting the mixture into a tumor area, and carrying out photo-crosslinking immobilization; culturing for 7-14 days under the dynamic perfusion condition of a mixed culture medium to obtain a three-dimensional gastric cancer organ model containing a capillary network; the method is expected to be used for rapid, low-cost and high-throughput screening of chemotherapy or anti-angiogenesis drugs and accurate prediction of individual curative effects of patients.

The invention provides a coding gene of coral-derived anticoagulant polypeptide and application, and belongs to the technical field of bioactive peptides. The invention provides an anticoagulant polypeptide GcKuz1. The anticoagulant polypeptide GcKuz1 comprises a mature peptide fragment as shown in SEQ ID No.1. The invention also provides a preparation method of the anticoagulant polypeptide GcKuz1. The polypeptide GcKuz1 is combined with KLKB1 in a thrombin system, so that the anti-thrombus and anti-coagulation effects are achieved, and the polypeptide does not cause hemolysis and cytotoxicity, has no bleeding risk and has good biological safety. The anticoagulant polypeptide disclosed by the invention has the effect of treating thrombotic diseases, such as arterial thrombotic diseases, venous thrombotic diseases and capillary thrombotic diseases.

The invention belongs to the technical field of biology, and particularly relates to a construction method and application of a Car4 gene tracing animal model based on CRISPR / Cas9. According to the invention, an EGFP-CreERT2 gene knock-in mouse controlled by a Car4 gene is constructed in a gene insertion manner. While expressing the CA4 protein, the mouse also expresses fusion protein of EGFP (Enhanced Green Fluorescent Protein), a ligand binding region mutant (ERT) of an estrogen receptor and Cre recombinase. When the gene is knocked into a mouse, the EGFP can well play a role in tracing the CA4 protein; the insertion of the EGFP and CreERT2 genes does not have obvious influence on the expression and function of CA4 in cardiac muscle tissues; when the gene is inserted into a mouse to realize CA4 protein tracing, a reliable Cre tool mouse is provided for realizing conditional knockout of a target gene in capillary endothelial cells in heart tissues.

Methods and compositions are disclosed for treating and preventing cytokine release syndrome (CRS). acute respiratory distress syndrome (CRS), and alveolar capillary injury (ACI) in a subject.

A method of manufacturing a preform for use in the manufacturing process of a hollow-core photonic crystal fiber, the method comprising: (i) providing an elongated preform jacket with a hollow inner structure, the elongated preform jacket having a first and second end; (ii) inserting a hollow capillary preform into the hollow inner structure such that the hollow capillary preform is in contact with the hollow inner structure at a contact position and protrudes out of the hollow inner structure at the first end and at the second end; (iii) at the first end, locally heating a protruding portion of the hollow capillary preform; (iv) bending the protruding portion around the first end of the preform jacket; and (v) applying additional heat to a portion of the hollow capillary preform that is bent around the elongated preform jacket to fuse it to an outer surface of the elongated preform jacket.

The present invention relates to a whitening composition suitable for sensitive skin and having a skin barrier repairing effect, and the use thereof, and belongs to the field of daily chemicals. The whitening composition of the present invention comprises the following components in parts by weight: 0.001 to 10 parts of a Radix mori albae extract, 0.001 to 10 parts of a Boerhavia diffusa extract, and 0.001 to 10 parts of a Mentha spicata extract. The whitening composition of the present invention is beneficial to inhibiting the generation of melanin, and simultaneously reducing capillary leakage via vascular factors to improve the barrier of sensitive skin, and therefore the whitening composition achieves the effects of more comprehensive and uniform skin whitening. In the present invention, an Eriobotryae folium extract, a Schisandrae sphenantherae fructus extract and a Crocus sativus extract are also added, which are beneficial to promoting the autophagy effect of the whitening composition on melanin, thereby accelerating the generation of lysosomes for melanin metabolism, and which can inhibit the inflammatory response and the overexpression of nerves, so that the effects of improving skin flushing and relieving and repairing sensitive skin are improved.

The present invention relates to a system (100) for monitoring one or more physiological parameters of an individual. The system (100) comprises an optical fibre assembly (110) configured to measure one or more physiological parameters of an individual, and a pressure sensor (120) configured to measure a contact pressure of the optical fibre assembly (110) on the individual. The pressure sensor (120) comprises an optical fibre (122) comprising a transducer fibre Bragg grating (127) embedded in a matrix (121). The matrix (121) is configured to cause longitudinal strain in the transducer fibre Bragg grating (127) in response to the matrix (121) being subject to a transverse load. The one or more physiological parameters that the system (100) is for monitoring may include blood oxygen saturation (Sp O2), capillary refill time (CRT), heart rate, blood flow and CO2 emissions from skin.

The invention discloses a composition with anti-hair loss and hair development efficacy, which is prepared from the following raw materials in weight percentage: 50-60% mulberry leaf essence, 10-20% lotus seed heart essence, 20-30% forsythia essence, 1-10% orientalis leaf essence, 10-20% green tea essence, and 1-10% lactobacillus fermentation liquid. The composition of the present invention effectively exerts a synergistic effect through different raw material action mechanisms, enhances VEGF and LEFI target expression, and achieves anti-hair loss and hair development through the following two approaches: first, regulating capillary growth and local blood circulation, providing nutrition for hair follicle growth; second, promoting the proliferation and differentiation of hair follicle cells, extending the hair follicle growth cycle, inhibiting hair follicle cell apoptosis, stimulating hair follicle growth factor and consolidating new and old hair follicles, thereby achieving the effect of anti-hair loss and hair development.

The invention relates to a pathological pulmonary fibrosis model and a construction method and application thereof. The pathological pulmonary fibrosis model provided by the invention is good in stability and controllability and high in maturity, not only can better simulate the function and structural characteristics of pulmonary alveoli-capillary barrier, but also has the pathological characteristics and immune microenvironment of pulmonary fibrosis lesions, has the advantage of high simulation degree, and has good application prospects in simulation and research of pulmonary fibrosis diseases. Good application prospects are realized in the aspects of drug detection, screening, evaluation, research and development and the like.

According to the endoscope imaging fusion enhanced imaging method and device, imaging characteristics of white light (an overall structure background), red light (a deep blood vessel), green light (a high-contrast capillary vessel) and blue light (an enhanced surface microstructure) are comprehensively utilized, digestive tract mucosa can be analyzed in a layered mode, and comprehensive diagnosis and early focus recognition from the surface layer to the deep layer are achieved; during image fusion, adaptive weight configuration based on focus types is supported by adopting a weight dynamic adjustment mechanism, so that the quality of the finally fused image is influenced, and therefore, a neural network architecture is adopted to train each channel weight, and a more reasonable weight value can be obtained.

The invention provides a carotid artery flow reduction thrombus protection device, and relates to the technical field of interventional medical instruments. The fixing assembly comprises a guide wire rod body, the guide wire rod body penetrates through the flow blocking part, and the flow blocking part is fixed to the guide wire rod body. The flow blocking part comprises a first opening located at the near end and a second opening located at the far end, the cross-sectional area of the second opening in the radial direction of the blood vessel is smaller than 30% of the cross-sectional area of the first opening in the radial direction of the blood vessel, and the flow blocking part reduces the blood flow in the carotid artery blood vessel when blood flows from the first opening to the second opening. The flow blocking part is arranged and provided with the first opening and the second opening, and the sectional area of the second opening in the radial direction of the blood vessel is smaller than half of the sectional area of the first opening in the radial direction of the blood vessel, so that the flow of blood is limited, and the pressure in the blood vessel is reduced; the problem that capillary injury is easily caused when blood flow directly recovers to the third level (mTICI level) is solved.

According to the technical scheme, the invention discloses a non-invasive pulmonary arterial pressure and capillary wedge pressure continuous estimation device which comprises a three-axis inertial sensing module, an acoustic sensing module, an electrocardio electrode module, a feature extraction module, a calibration and estimation module and an edge calculation module. Single three-axis inertial sensing and acoustic signal fusion are utilized, and the PAP and the PCWP are continuously estimated in a non-intrusive mode through a calibration regression / deep learning algorithm. According to the invention, single inertia and acoustics are innovatively taken as a collection core, and a calibration-estimation closed loop is supplemented, so that the device has the advantages of long-term continuous monitoring and real-time output of hemodynamic parameters in low-trauma, wearable and mobile environments.

The invention provides a method and system for evaluating facial skin aging, and the method comprises the steps: obtaining visible light, ultraviolet reflection and near-infrared spectrum images through multispectral imaging, and extracting skin texture, color spots and capillary network parameters through preprocessing; constructing a three-dimensional facial skin model, and measuring skin elasticity parameters in combination with a mechanical sensor; and inputting the parameters into a deep learning aging evaluation model, outputting a comprehensive evaluation report containing the physiological age of the skin, the elasticity grade and the regional aging difference index, and providing personalized aging protection suggestions. According to the method, multi-modal data and a deep learning technology are fused, multi-dimensional quantitative evaluation is realized, the method has the characteristics of high precision, objectivity and individuation, a powerful tool is provided for skin health management, and the method has a wide application prospect.

The invention discloses a stem cell preparation for treating pulmonary fibrosis. The stem cell preparation is mesenchymal stem cell surface modified nanoparticles. The nanoparticles are ROS (reactive oxygen species) response type lipid polymer hybrid nanoparticles loaded with an anti-fibrosis drug. According to the invention, a hydrophobic drug and a hydrophilic anti-fibrosis drug can be simultaneously loaded through the reductive hybrid nanoparticles, and can be delivered to the lung by utilizing the inflammation targeting capability of stem cells. The polymer in the nanoparticles reacts with active oxygen in the microenvironment to promote drug release, and then the effect of protecting stem cells is achieved. The released medicine can induce dedifferentiation of myofibroblasts and inhibit apoptosis of vascular endothelial cells and endothelial mesenchymal transformation, and the mesenchymal stem cells release growth factors at the same time to promote angiogenesis, reconstruct capillary structures deleted in fibrosis areas, promote lung tissue regeneration and recover lung functions to achieve the effect of treating pulmonary fibrosis.

The invention provides a cell active peptide composition with anti-allergy and red fading effects and a preparation method and medical beauty application thereof, and belongs to the technical field of medicine and beauty. The composition is prepared from dipeptide-1, tripeptide-1, palmitoyl tripeptide-8, palmitoyl tetrapeptide-7, sh-pentapeptide-1, hydrolyzed silk, a mussel extract, dipeptide-2, acetyl tetrapeptide-3, ceramide, 4-tert-butyl cyclohexanol, bisabolol, sodium hyaluronate and the like. The composition can repair skin barrier injury; the skin nerve dysfunction is improved; the immune function is enhanced, and skin inflammation is eliminated; the elasticity of capillary walls is enhanced, and couperose skin is repaired. The composition disclosed by the invention is applied to skin medicine and skin beauty, can effectively reduce the skin redness average value, the red area and the redness a value, strengthens the brick wall structure, is mild in effect, and has the functions of resisting allergy, fading red, relieving, calming and regulating immunity.

The invention provides a co-culture system of human alveolar epithelial cells and endothelial cells, which is used for researching interaction in an epithelial-endothelial barrier in lungs. It is indicated that infection with the highly pathogenic influenza A virus A / HK / 483 / 97 (H5N1) can significantly reduce alveolar fluid clearance (AFC) and increase protein permeability (APP). Administration of therapeutic extracellular vesicles (EV) after infection effectively restores AFC and APP, reduces viral replication, and enhances expression of antiviral genes. According to the invention, the treatment potential of EV is highlighted, and a valuable tool is provided for researching acute lung injury and improving a lung drug delivery technology.

The invention relates to application of roxburgh rose-derived exosomes (RrNVs) in preparation of products for preventing, improving or treating acute lung injury (ALI). Specifically, the rosa roxburghii tratt exosome (RrNVs) can effectively inhibit inflammation, improve the acute lung injury symptom, reduce the release of inflammatory cells and inflammatory mediators in the acute lung injury state, and relieve the pulmonary edema condition, the lung tissue leakage condition and the lung capillary permeability condition in the inflammatory state. Meanwhile, the RrNVs can also regulate and control the intestinal flora structure, improve the abundance of beneficial bacteria and reduce the abundance of harmful bacteria, and the discovery provides a basis for the RrNVs as potential functional food, medicine and the like of ALI.

The invention relates to a lung in-vitro model and a construction method and application thereof. The lung in-vitro model provided by the invention is good in stability and controllability and high in maturity, can better simulate functions and structural characteristics of pulmonary alveoli-capillary barriers, has the advantage of high simulation, and has a good application prospect in the aspects of disease simulation, drug detection, screening, evaluation, research and development and the like.

The invention discloses a preparation method and application of an endothelium corneum gigeriae galli and angelica sinensis ointment, and relates to the technical field of traditional Chinese medicine, the endothelium corneum gigeriae galli and angelica sinensis ointment comprises the following raw materials in parts by weight: a medicine solution: 1-3g of angelica sinensis extract and 30-35 parts of endothelium corneum gigeriae An oil phase: 1-5 g of white vaseline, 1-5 g of glycerin monostearate, 10-14 g of stearic acid, 5-8 g of liquid paraffin and 3-6 g of wool fat; a water phase: 0.2 to 0.5 g of triethanolamine, 0.5 to 1 g of glycerin, and 0.1 to 0.5 g of ethylparaben; according to the endothelium corneum gigeriae galli and angelica sinensis ointment, endothelium corneum gigeriae galli and angelica sinensis materials are adopted, endothelium corneum gigeriae galli has the effects of healing sore, promoting tissue regeneration, removing blood stasis and the like, angelica sinensis has the effects of replenishing qi, enriching blood and promoting blood circulation to remove blood stasis, and skin wound healing and capillary regeneration can be effectively promoted, local blood circulation is improved, and inflammatory response is inhibited; meanwhile, the ointment is soft in texture and can absorb percolate and inhibit microbial infection; the method is convenient, economical, practical, good in stability and suitable for application and popularization.

The invention relates to a pulmonary fibrosis model and a construction method and application thereof. The pulmonary fibrosis model provided by the invention is good in stability and controllability and high in maturity, can better simulate functions and structural characteristics of pulmonary alveoli-capillary barriers, has the advantage of high simulation, and has a good application prospect in the aspects of disease simulation, drug detection, screening, evaluation, research and development and the like.

A falling film heat exchanger, a falling film plate heat exchanger, a falling film shell and tube heat exchanger, and a sorption heat pump or chiller are described. The falling film heat exchangers are equipped with a capillary structure featuring capillary grooves or ribs. These grooves or ribs are oriented perpendicular to the flow direction of the falling film, ensuring a lateral distribution of the fluid along the grooves. A heat exchanger whose heat exchange surfaces are equipped with such a capillary structure guarantees effective wetting of the heat exchange surface even with just a few inlet points of the spray system. The inlet point is defined as the point at the top of the heat exchange surface where the fluid is brought into contact with the surface and subsequently flows down.In addition to improving the degree of wetting, the capillary structure also increases the effective heat exchanger surface area, leading to a further increase in heat transfer.

To provide a method for manufacturing a precast residual formwork panel, which suppresses the formation of capillary voids in a precast residual formwork concrete panel body and improves the water impermeability of the precast residual formwork concrete panel body.SOLUTION: There is provided a manufacturing method of a precast residual formwork panel for use in the manufacture of a water-impermeable precast residual formwork panel, which includes: a mixing step of mixing a concrete raw material containing cement, gravel as crushed stone aggregate of limestone and sand as crushed stone aggregate of limestone with kneading water heated to a temperature of 60°C to 85°C in advance to obtain a fluidized cement composition having an as-mixed temperature of 15°C to 45°C corresponding to an outside air temperature of 0°C to 40°C; and a heat insulation curing step of naturally lowering the temperature of the fluidized cement composition to the outside air temperature without externally re-heating the fluidized cement composition charged into a forming mold so as to suppress a bleeding phenomenon in which the fluidized cement composition is discharged to the outside of the forming mold by expansion of the kneading water.SELECTED DRAWING: Figure 1

The invention relates to the technical field of medicines, in particular to application of lycium barbarum-derived extracellular vesicles in preparation of a medicine for treating acute kidney injury. The used extracellular vesicles derived from Chinese wolfberry fruits have a lipid bilayer membrane structure, are good in stability, free of remarkable toxicity, good in blood compatibility and high in-vivo safety after long-term intravenous injection, are used for preparing the medicine for treating the acute kidney injury, and can reduce apoptosis, inhibit rising of blood urea nitrogen and creatinine levels and relieve injury of kidney tissues; the invention further provides application of the extracellular vesicles derived from the Chinese wolfberry fruits in preparation of the medicine for treating the lung injury disease, the weight loss is relieved, lung tissue is protected, meanwhile, the pulmonary alveolar-capillary barrier can be repaired, and in addition, the medicine can be used for treating the lung injury disease. The invention also provides application of the extracellular vesicles derived from Chinese wolfberry fruits in preparation of nuclear transcription factor kappa B inhibitors and / or inhibition of apoptosis and / or repair of pulmonary alveolar capillary barriers.

The disclosure provides methods for analyzing two or more different proteins co-formulated in a sample mixture. The methods involve cation exchange-high performance liquid chromatography (CEX-HPLC), size exclusion ultra high performance liquid chromatography (SE-UHPLC), and / or capillary electrophoresis (CE) optimized to accurately determine the concentration, and assess certain critical quality attributes of, each protein in the sample.

The invention relates to a double-layer Janus fiber sleeve and a preparation method and application thereof.Materiology, in-vitro cell experiments and in-vivo tendon injury model repair experiments are carried out through implantation, and through the repair effect of the double-layer Janus fiber sleeve on injured tendon tissue, the double-layer Janus fiber sleeve has the advantages of the anisotropic structure of the Janus structure, so that the double-layer Janus fiber sleeve has a good application prospect. Rearrangement and induced regeneration of tendon cells by an inner layer structure are achieved, and the tendon forming performance of tendons can be activated under the condition that shearing force is generated when normal tendon sliding is simulated in vitro; and the outer-layer staggered fiber structure can effectively block invasion of scar fibers, avoid excessive deposition of the scar fibers, induce new capillaries to grow into the stent to realize enrichment of nutrient substances in the blood vessels, and finally realize non-scar healing of the tendons.

A grey-scale tomography of a sample is obtained and a capillary network model (CNM) geometry of the sample is produced, using a capillary network extractor, based on the grey-scale tomography. A fluid flow simulation is performed, using a flow simulator, to generate flow property fields based on the capillary network model (CNM) geometry. A mineralization simulation is performed influenced by results of the flow property fields to generate a modified capillary geometry that represents the capillary network model (CNM) geometry at a future point in time.

The invention belongs to the technical field of biochips, and relates to a blood vessel microcirculation chip and system for in-vitro three-dimensional tissue. The blood vessel microcirculation chip of the in-vitro three-dimensional tissue comprises a chip shell component with a culture tank, an in-vitro three-dimensional tissue is arranged in the culture tank, and the in-vitro three-dimensional tissue comprises a matrix, cells in the matrix and a microcirculation vessel network in the matrix; the microcirculation vessel network in the matrix comprises a bionic artery, a bionic vein and a self-development capillary network in the matrix. The in-vitro three-dimensional tissue blood vessel microcirculation chip and system provided by the invention have bionic artery, bionic vein and capillary networks similar to organisms, and simulate the blood vessel microcirculation process of arterial high-pressure exudation mass transfer and oxygen transfer and vein low-pressure reflux metabolism.