152 results about "Capillary vessels" patented technology

The invention provides a preparation method of medicinal liquor and application of the medicinal liquor in preparation of analgesic and anti-inflammatory products, and relates to the technical field of medicines. The preparation method comprises the following steps: (1) crushing; (2) extracting; (3) standing and separating; and (4) freezing and filtering to obtain the medicinal liquor. In the preparation process, traditional Chinese medicine components are extracted through the steps of batch crushing, mixed extraction, standing, freezing and separation of supernate and suspension in different separation modes to obtain the medicinal liquor, and the medicinal liquor can better inhibit pain caused by thermal stimulation and chemical substances and has a better analgesic effect; the traditional Chinese medicine composition can inhibit capillary permeability increase caused by acetic acid, has a better effect of inhibiting inflammation exudation, and has remarkable analgesic and anti-inflammatory effects.

The invention relates to the technical field of tumor biomedical engineering and organ chips, in particular to a vascularized gastric cancer organ chip and a preparation method thereof.The chip is composed of an integrated micro-fluidic main body, an annular micro-column array and an optical sealing film, and a central culture cavity is divided into a tumor area and a blood vessel area by micro-columns; the preparation method comprises the following steps: injecting a fibrous protein solution containing human umbilical vein endothelial cells and cancer-related fibroblasts into a vascular region, and adding thrombin for in-situ gelation to form a pre-vascularized network; the method comprises the following steps: mixing a patient-derived gastric cancer organ with a methacrylic acid esterified gelatin pre-polymerized solution, injecting the mixture into a tumor area, and carrying out photo-crosslinking immobilization; culturing for 7-14 days under the dynamic perfusion condition of a mixed culture medium to obtain a three-dimensional gastric cancer organ model containing a capillary network; the method is expected to be used for rapid, low-cost and high-throughput screening of chemotherapy or anti-angiogenesis drugs and accurate prediction of individual curative effects of patients.

The invention provides a method and system for evaluating facial skin aging, and the method comprises the steps: obtaining visible light, ultraviolet reflection and near-infrared spectrum images through multispectral imaging, and extracting skin texture, color spots and capillary network parameters through preprocessing; constructing a three-dimensional facial skin model, and measuring skin elasticity parameters in combination with a mechanical sensor; and inputting the parameters into a deep learning aging evaluation model, outputting a comprehensive evaluation report containing the physiological age of the skin, the elasticity grade and the regional aging difference index, and providing personalized aging protection suggestions. According to the method, multi-modal data and a deep learning technology are fused, multi-dimensional quantitative evaluation is realized, the method has the characteristics of high precision, objectivity and individuation, a powerful tool is provided for skin health management, and the method has a wide application prospect.

The invention relates to application of roxburgh rose-derived exosomes (RrNVs) in preparation of products for preventing, improving or treating acute lung injury (ALI). Specifically, the rosa roxburghii tratt exosome (RrNVs) can effectively inhibit inflammation, improve the acute lung injury symptom, reduce the release of inflammatory cells and inflammatory mediators in the acute lung injury state, and relieve the pulmonary edema condition, the lung tissue leakage condition and the lung capillary permeability condition in the inflammatory state. Meanwhile, the RrNVs can also regulate and control the intestinal flora structure, improve the abundance of beneficial bacteria and reduce the abundance of harmful bacteria, and the discovery provides a basis for the RrNVs as potential functional food, medicine and the like of ALI.

The invention relates to the technical field of medicines, in particular to application of lycium barbarum-derived extracellular vesicles in preparation of a medicine for treating acute kidney injury. The used extracellular vesicles derived from Chinese wolfberry fruits have a lipid bilayer membrane structure, are good in stability, free of remarkable toxicity, good in blood compatibility and high in-vivo safety after long-term intravenous injection, are used for preparing the medicine for treating the acute kidney injury, and can reduce apoptosis, inhibit rising of blood urea nitrogen and creatinine levels and relieve injury of kidney tissues; the invention further provides application of the extracellular vesicles derived from the Chinese wolfberry fruits in preparation of the medicine for treating the lung injury disease, the weight loss is relieved, lung tissue is protected, meanwhile, the pulmonary alveolar-capillary barrier can be repaired, and in addition, the medicine can be used for treating the lung injury disease. The invention also provides application of the extracellular vesicles derived from Chinese wolfberry fruits in preparation of nuclear transcription factor kappa B inhibitors and / or inhibition of apoptosis and / or repair of pulmonary alveolar capillary barriers.

The invention belongs to the technical field of experiments and the field of anatomical research, and particularly relates to a self-developing vascular casting agent and a preparation method thereof. The invention discloses a preparation method of a self-developing vascular casting agent. The self-developing vascular casting agent is obtained by uniformly mixing iopromide, natural latex, II-type barium sulfate and pigment, wherein in parts by weight, the iopromide accounts for 30-40%; 25%-30% of natural latex; 40% of type II barium sulfate; and 5%-10% of pigment. The blood vessel casting agent developed by the invention is excellent in formula flowability (smooth perfusion), does not cause blockage, can avoid reverse osmosis of a capillary microenvironment, and realizes arteriovenous differentiated perfusion; and meanwhile, high-contrast development is realized, and complete coverage of capillary vessels is basically realized. The optimized blood vessel casting agent formula is completely cured (at room temperature) within 24 hours, the shrinkage rate is low, and blood vessel deformation is avoided.

The present application relates to a kind of wearable capillary perfusion real-time noninvasive monitoring device, including temperature acquisition module (1) and information processing module (2) connected by wireless communication, temperature acquisition module (1) includes sequentially stacked connection acquisition module top package (11), acquisition module upper layer (12), acquisition module middle package (13), acquisition module lower layer (14) and acquisition module bottom package (15), acquisition module upper layer (12) is connected with acquisition module lower layer (14) by wire (16);Temperature acquisition module (1) is directly contacted with skin above capillary, measures the temperature response of skin under heat source;Information processing module (2) analyzes temperature signal, calculates skin heat transfer coefficient by non-steady-state heat conduction principle, and then converts into skin capillary perfusion volume.Compared with prior art, the present application is small and light, suitable for wearing, suitable for real-time noninvasive monitoring of capillary perfusion under the overload condition of pilot.

The invention discloses a freckle-removing and whitening mask which is prepared from the following raw materials: chrysanthemum, pearl, radix angelicae, almond, poria cocos, rhizoma atractylodis macrocephalae, peach kernel, ginseng, mung bean, bletilla striata, cortex moutan, rhodiola rosea, silkworm larva, Chinese yam, honeysuckle and the like. The facial mask is a pure traditional Chinese medicine facial mask, has remarkable curative effects on whitening, removing freckles, removing acnes and minimizing pores, and can effectively reduce facial skin damage, effectively inhibit growth of facial germs, promote vigor of subcutaneous capillaries of the damaged face, improve metabolism of the skin and enable the facial skin to reappear in a compact and refined state. In addition, the facial mask can enhance the ability of facial skin to resist invasion and stimulation of external germs, form a natural protective barrier for the facial skin, well repair, moisten and care the facial skin, and keep the facial skin comfortable, beautiful and healthy for a long time. Pure traditional Chinese medicine raw materials are selected, chemical components are not added, and harm to facial skin and the body is avoided.

An embodiment may be a method for early diagnosis and management of varicose veins by a server, which may include the steps of acquiring varicose vein-related information from a user device, quantifying the degree of capillary exposure based on an analysis of the varicose vein-related information, evaluating the risk of varicose veins based on the quantified degree of capillary exposure, and transmitting evaluation result information for varicose veins to the user device based on the evaluated risk of varicose veins.

The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here the inventors show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases. Cd9 gene targeting in PECs prevents glomerular damage in CGN and FSGS mouse models. Mechanistically, CD9 deficiency prevents the oriented migration of PECs into the glomerular tuft and their acquisition of CD44 and β1 integrin expression. These findings highlight a critical role for de novo expression of CD9 as a common pathogenic switch driving the PEC phenotype in CGN and FSGS, while offering a potential therapeutic avenue to treat these conditions. Accordingly, CD9 represents a reliable biomarker and as well as a biotargets in glomerulonephritides.

The application belongs to the field of pharmacy, and particularly relates to a whole-process targeting polypeptide molecule with the functions of targeting brain capillary endothelial cells, tumor neovascular endothelial cells, tumor pseudo vascular, tumor cells and tumor stem cells, a stable and optimized polypeptide molecule, and a modified complex and drug delivery system for tumor diagnosis and treatment. The application prepares a whole-process targeting polypeptide WVAP and a WVAP modified drug and high polymer carrier material, and applies the WVAP to the construction of a drug delivery system for tumor imaging and targeted therapy. The results show that the WVAP can cross the blood-brain barrier, target tumor neovascular and cross the blood-tumor barrier, target tumor pseudo vascular, tumor cells and tumor stem cells; and the nano drug delivery system constructed by the WVAP modified high polymer carrier material can effectively deliver the loaded drug to the brain, target tumor tissues, and significantly improve the anti-tumor efficacy.

Provided are novel chiral aromatic diazatricyclo-compounds and pharmaceutically acceptable salts thereof, that are smooth muscle myosin 2 specific inhibitors useful for the treatment of ischemic events and conditions associated with capillary no-reflow, or other smooth-muscle related symptoms.

The present invention relates to a method and apparatus for determining the activity of clotting factors in diluted capillary whole blood, citrated whole blood and citrated plasma. The invention also includes the detection of hemoglobin content in the whole blood sample to correct for clotting time so that the clotting time values are not affected by hemoglobin and hematocrit.

The utility model relates to the technical field of practice teaching molds, and discloses a compression hemostasis teaching aid for adolescent emergency training, which is provided with a liquid bag, a simulated artery blood vessel, a simulated vein blood vessel, a simulated capillary and a micro pump, the liquid bag is used for storing simulated blood; the simulated artery blood vessel, the simulated vein blood vessel and the simulated capillary blood vessel are all of transparent structures and are respectively connected with the liquid bag, and the simulated artery blood vessel, the simulated vein blood vessel and the simulated capillary blood vessel are respectively connected with valves for controlling the on / off state of a pipeline; the micro pump is used for outputting pumping pressure to the liquid bag, and the pumping pressure of the micro pump is adjustable corresponding to the set flow velocity of the simulated artery blood vessel, the simulated vein blood vessel and the simulated capillary blood vessel. The first-aid training device can simulate different blood vessels of a human body and press the corresponding blood vessels to force blood flow in the corresponding blood vessels to be stopped, so that teenagers can practice operation in training, and the teaching effect of first-aid training of the teenagers is effectively improved.

The present invention relates to a non-vascular injection formulation comprising nanoparticles, the hydrodynamic diameter of which is adjusted to 2 to 20 nm and the surface charge of which is adjusted to-20 to 0 mV by hydration of hydrophilic functional groups exposed on the surface of the nanoparticles such that the nanoparticles do not permeate into or expel into the capillaries of the administration site, the nanoparticles are only selectively excreted into the peripheral lymphatic vessel, but only selectively excreted into the peripheral lymphatic vessel, wherein the nanoparticles: (i) themselves are therapeutic agents; and / or (ii) a carrier for other drugs, thereby providing a drug form in which the nanoparticles are expelled only into the peripheral lymphatic vessel when injected into a tissue region without intravenous administration, thereby extending the residence time at the injection site. Nanoparticles having adjusted hydrodynamic diameter and surface charge according to the present invention can be excreted from the body within a week after administration without any residue at the site of administration, when designed as contrast agents exhibiting a T1MRI contrast effect and injected into tissues in the vicinity of the blood vessel, the nanoparticles can be used as contrast agents that exhibit a T1MRI contrast effect. Peripheral and / or central lymphatic vessels may be selectively imaged without venous contamination.

In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides to treat, prevent, or reduce the progression rate and / or severity of post-capillary pulmonary hypertension (PcPH), particularly treating, preventing or reducing the progression rate and / or severity of one or more PcPH-associated complications.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

A method of measuring tissue properties using a fluid line in fluid communication with a subcutaneous tissue includes applying a pressure profile or flow profile to the subcutaneous tissue via the fluid line, with the fluid line isolated from atmospheric pressure, measuring a pressure value or flow rate value over time in response to the applied pressure profile or applied flow profile, and calculating, using at least one processor, at least one of the following: time constant of pressure decay; fluidic resistance of tissue; permeability of tissue; mechanical compliance of tissue; osmotic pressure of interstitial fluid of tissue; capillary pressure in subcutaneous tissue; and ionic strength of interstitial fluid.

The invention discloses application of octyl 4-itaconate in preparation of a medicine for promoting proliferation, migration or scratch healing of vascular endothelial cells, and belongs to the technical field of medicines for vascular diseases. The medicine is 4-octyl itaconate, the administration dosage of the medicine is 25-30 mg / kg of body weight, and the concentration of the 4-octyl itaconate in the medicine is 5-8 mg / mL. The octyl 4-itaconate can promote proliferation, migration or scratch healing of vascular endothelial cells, so that blood flow of lower limb blood vessels after lower limb ischemia reperfusion is remarkably recovered, lesions of lower limb muscular tissues are relieved, new blood capillaries are promoted, and the curative effect is improved. Therefore, the compound has a wide clinical application prospect in preparation of drugs for promoting proliferation, migration or scratch healing of vascular endothelial cells.

The present invention relates to a culture related to the antigen sensitization status of the transplantation of capillary endothelial cells, to the use of said culture, and also to a test kit comprising said culture.

The invention provides a capillary network hemodynamic modeling method with a multilayer structure, and aims to solve the problem that a traditional model is difficult to truly reflect a capillary multilayer structure and blood flow topological characteristics, and combines the hierarchical structure characteristics of a capillary network disclosed by a high-resolution imaging image. And constructing a multi-layer blood vessel network model consisting of a microarteriovenous layer, a connecting layer and a capillary network layer. Wherein the micro artery and vein layer is a tree-shaped blood vessel network formed by micro arteries and micro veins; the capillary network layer is of a regular network blood vessel structure constructed based on a hexagonal grid; and the connecting layer is a connecting blood vessel for connecting the microarteriovenous layer and the capillary network layer. Through standardized numbering rules, node insertion and blood vessel splitting operation, embedding, reconstruction and overall structure integration of blood vessel segments are completed, and therefore a capillary network system which is complete in structure and is in topological communication is constructed. On the basis of structural modeling, a linear equation solving system is established for hemodynamic simulation. The method has the advantages in the aspects of structural definition, simulation precision and expansibility, and has important scientific research and engineering application value.

The invention relates to the field of herbal fragrant moxibustion, in particular to an edible and medicinal inhalation type atomized moxibustion material and a preparation method thereof. The invention relates to an edible and medicinal inhalation type moxibustion atomized material which comprises the following raw materials in parts by weight: 8-11 parts of astragalus membranaceus, 5-6 parts of pericarpium citri reticulatae, 6-10 parts of radix puerariae, 10-12 parts of agilawood, 8-12 parts of poria cocos, 7-9 parts of radix ophiopogonis, 20-25 parts of a carrier, 2-3 parts of an adhesive and the balance of water, wherein the total weight part is 100; the carrier comprises at least one of lotus leaves and loquat leaves; the adhesive comprises at least one of guar gum and pregelatinized starch. According to the application, the medicine taking astragalus membranaceus as a main medicine is prepared into the edible and medicinal inhalation type moxibustion atomized material, and the medicine can be absorbed in an aerosol inhalation mode during use. And after the moxibustion atomized material is prepared, the medicine medium has higher penetrability, can reach blood capillaries of a human body more easily, and has a stronger conditioning effect.

The utility model relates to a colon cancer metastasis microfluidic dynamic simulation device suitable for experiment teaching, which comprises microfluidic driving equipment, a dynamic simulation module and a teaching imaging system, the dynamic simulation module comprises an invasion layer, an intestinal tract simulation layer and a blood vessel metastasis layer from top to bottom, the invasion layer is used for placing freeze-drying dyeing marked colon cancer cells, and the intestinal tract simulation layer is used for placing the blood vessel metastasis layer. The bottom of the invasion layer is composed of a capillary simulation plate for simulating capillaries, the bottom of the intestinal tract simulation layer is composed of a common blood vessel simulation plate for simulating common blood vessels, and the microfluidic driving device is connected with the input end in the blood vessel transfer layer and simulates blood flow. The teaching imaging system comprises an excitation light source for exciting the dyeing marks, a long working distance objective lens for observing the dynamic simulation module and a microscopic camera for shooting the dynamic simulation module. By adopting the scheme, the utility model provides the colon cancer metastasis micro-fluidic dynamic simulation device suitable for experiment teaching, which can observe the metastasis process in real time, has low operation complexity and is suitable for experiment teaching, so that the teaching effect is improved.

The invention discloses a postpartum placenta blood vessel developing kit. The postpartum placenta blood vessel developing kit comprises polypropylene watercolor powder which is pre-packaged in a vacuum bottle and has the particle size of 100-300nm; the bagged normal saline is uniformly mixed with the polypropylene watercolor powder to form a polypropylene-based main developing agent; the blood vessel lock catch is used for clamping and closing the blood vessel and preventing the polypropylene-based main developing agent from flowing back through the umbilical cord blood vessel; the injector is used for respectively injecting the polypropylene-based main developing agent into the umbilical artery and the umbilical vein; the graduated scale is used for measuring the size of the placenta. By pre-preparing the dye, uniform concentration, sterility, reliability and simplicity and convenience in operation are ensured; the dye particle size can be controlled to avoid capillary blockage, and the developing quality is improved; the method can also meet diversified clinical requirements of multi-fetal, radiography verification, anticoagulation pretreatment and the like.

The invention discloses an air blocking plug for nasal capillary hemorrhage based on HHT, and relates to the technical field of medical auxiliary instruments, the air blocking plug comprises a support part, a fitting part and a movable part, the air blocking plug is carried out along with breathing, so that the air blocking plug is automatically generated along with breathing and alternately resists the compression of elastic frames on the two sides to the nasal cavity; at least one group of elastic frames on the two sides of the nasal septum and the two sides of the nose wings can be attached and fixed to the nasal cavity, and loosening and displacement are avoided; through the arrangement of the cotton thread, during use, water can be sucked in the cotton thread through one end of the outer bent frame, the part, making contact with the cotton thread, of the pull line is moved out of the outer side rod along with the inactivity of the pull line, water is increased for gas, damage of dry airflow is reduced, and stimulation of the airflow to blood capillaries is further relieved through the wetting effect. Meanwhile, the device belongs to a built-in type and is hidden in wearing, and the patient compliance is high.

The invention belongs to the technical field of micro-fluidic chips, and provides a micro-fluidic lung chip for simulating child lung physiological characteristics, and particularly aims at simulating specific respiratory frequencies of children at different growth stages, simulating a tissue barrier interface of pulmonary epithelium and endothelium, and simulating a fluid microenvironment. The micro-fluidic chip is mainly composed of two layers of micro-channels, the channels are separated by a polydimethylsiloxane porous membrane, two sides of each channel are respectively provided with a vacuum cavity, each layer of channel is provided with an inlet and an outlet, and a dynamic environment is formed through fluid. Lung epithelial cells and endothelial cells are respectively inoculated in the upper channel and the lower channel on the chip to form an alveolar-capillary interface on the chip. By applying negative pressure to the vacuum cavity, the respiratory frequencies of children in different growth stages are simulated. The invention provides a multi-factor participated tissue level research system for children lung diseases and children medicine research.

1. Name of the product in this design: Blood glucose meter. 2. Purpose of this design: This design is used to test the blood glucose level in fresh capillary whole blood samples. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The application provides a use of a teriparatide acetate in preparation of a medicine for preventing and / or treating acute respiratory distress syndrome, and belongs to the technical field of medicines.The application finds that after a mouse with acute respiratory distress syndrome (ARDS) is injected with the teriparatide acetate, neutrophil infiltration can be effectively reduced, and lung hemorrhage, lung capillary hyperemia and lung capillary septum thickening and other lung injury symptoms can be reduced.In addition, the teriparatide acetate can effectively prevent the occurrence of ARDS, can reduce the lung injury degree of the mouse, can reduce the neutrophil infiltration, lung hemorrhage and lung capillary hyperemia and other symptoms, can reduce the level of inflammatory factors in serum, and can reduce lung edema.Therefore, the teriparatide acetate can not only be used for treating acute respiratory syndrome and acute lung injury, but also can prevent the occurrence and development of acute respiratory syndrome, has a remarkable effect, is high in safety, and has a wide application prospect.

The present invention relates to a pathological pulmonary fibrosis model, a construction method therefor, and a use thereof. The pathological pulmonary fibrosis model provided by the present invention has good stability and controllability and high maturity, can better simulate the function and structural characteristics of the alveolar-capillary barrier, and has the pathological characteristics of pulmonary fibrosis lesions and the immune microenvironment. The model has the advantage of high simulation degree, and has good application prospects in the aspects of simulation and research of pulmonary fibrosis diseases, as well as drug detection, screening, assessment, and research and development, and the like.