279 results about "Capillary vessels" patented technology

The invention provides a preparation method of medicinal liquor and application of the medicinal liquor in preparation of analgesic and anti-inflammatory products, and relates to the technical field of medicines. The preparation method comprises the following steps: (1) crushing; (2) extracting; (3) standing and separating; and (4) freezing and filtering to obtain the medicinal liquor. In the preparation process, traditional Chinese medicine components are extracted through the steps of batch crushing, mixed extraction, standing, freezing and separation of supernate and suspension in different separation modes to obtain the medicinal liquor, and the medicinal liquor can better inhibit pain caused by thermal stimulation and chemical substances and has a better analgesic effect; the traditional Chinese medicine composition can inhibit capillary permeability increase caused by acetic acid, has a better effect of inhibiting inflammation exudation, and has remarkable analgesic and anti-inflammatory effects.

The invention relates to an adjusting system applied to continuous kidney replacement treatment of acute kidney injury patients. Comprising the following steps: capturing the blood flow velocity and vascular endothelial permeability of glomerular capillaries in real time by using a micro sensor or a nano-scale optical imaging technology; the method comprises the following steps: pre-judging a risk time point of insufficient tissue perfusion through dynamic modeling of a capillary structure and a functional relationship; combining the microcirculation data with conventional biochemical indexes of the patient to create an early intervention model; when it is monitored that microcirculation perfusion is greatly reduced or kidney oxygen supply is insufficient, continuous renal replacement therapy CRRT parameter fine adjustment is triggered in advance; the method comprises the following steps: collecting plasma toxins of different patients at clinical and molecular levels, and constructing a common toxin map of the acute kidney injury AKI; whether the specific toxin concentration exceeds the standard or not is judged by combining a real-time sensor, and the removal priority is output in real time; a membrane material with an adjustable aperture or a special coating is adopted, so that inflammatory mediators and bacterial endotoxin molecules are adsorbed or intercepted, and the permeability of micromolecular electrolyte is kept.

The invention provides a biological blood vessel bionic liquid cooling network heat dissipation method for a humanoid robot, and belongs to the technical field of robot heat dissipation. The biological blood vessel bionic liquid cooling network heat dissipation method for the humanoid robot comprises the following steps: carrying out embedded near-node heat dissipation with a driving source by utilizing a first heat dissipation unit according to the aorta-level local high-heat-flow heat dissipation requirement of a chip located at the brain of the humanoid robot through biological bionic mapping and global partition cascade thermal control; aiming at the high-dynamic multi-heat-source heat dissipation requirement of a joint motor located at a movable joint part of the humanoid robot, indirect heat dissipation with a driving source is carried out by utilizing a second heat dissipation unit; according to the capillary-level low-heat-flux heat dissipation requirement of a power battery located on the chest of the humanoid robot, self-driven indirect heat dissipation is conducted through the capillary pump effect by means of a third heat dissipation unit; and for vein-level liquid cooling backflow, large-area natural convection air cooling heat dissipation on the skin surface is simulated for global heat discharge, and finally the bionic liquid cooling heat dissipation method for the system-level humanoid robot is formed.

The invention relates to the technical field of tumor biomedical engineering and organ chips, in particular to a vascularized gastric cancer organ chip and a preparation method thereof.The chip is composed of an integrated micro-fluidic main body, an annular micro-column array and an optical sealing film, and a central culture cavity is divided into a tumor area and a blood vessel area by micro-columns; the preparation method comprises the following steps: injecting a fibrous protein solution containing human umbilical vein endothelial cells and cancer-related fibroblasts into a vascular region, and adding thrombin for in-situ gelation to form a pre-vascularized network; the method comprises the following steps: mixing a patient-derived gastric cancer organ with a methacrylic acid esterified gelatin pre-polymerized solution, injecting the mixture into a tumor area, and carrying out photo-crosslinking immobilization; culturing for 7-14 days under the dynamic perfusion condition of a mixed culture medium to obtain a three-dimensional gastric cancer organ model containing a capillary network; the method is expected to be used for rapid, low-cost and high-throughput screening of chemotherapy or anti-angiogenesis drugs and accurate prediction of individual curative effects of patients.

The invention provides a coding gene of coral-derived anticoagulant polypeptide and application, and belongs to the technical field of bioactive peptides. The invention provides an anticoagulant polypeptide GcKuz1. The anticoagulant polypeptide GcKuz1 comprises a mature peptide fragment as shown in SEQ ID No.1. The invention also provides a preparation method of the anticoagulant polypeptide GcKuz1. The polypeptide GcKuz1 is combined with KLKB1 in a thrombin system, so that the anti-thrombus and anti-coagulation effects are achieved, and the polypeptide does not cause hemolysis and cytotoxicity, has no bleeding risk and has good biological safety. The anticoagulant polypeptide disclosed by the invention has the effect of treating thrombotic diseases, such as arterial thrombotic diseases, venous thrombotic diseases and capillary thrombotic diseases.

The present invention relates to a system (100) for monitoring one or more physiological parameters of an individual. The system (100) comprises an optical fibre assembly (110) configured to measure one or more physiological parameters of an individual, and a pressure sensor (120) configured to measure a contact pressure of the optical fibre assembly (110) on the individual. The pressure sensor (120) comprises an optical fibre (122) comprising a transducer fibre Bragg grating (127) embedded in a matrix (121). The matrix (121) is configured to cause longitudinal strain in the transducer fibre Bragg grating (127) in response to the matrix (121) being subject to a transverse load. The one or more physiological parameters that the system (100) is for monitoring may include blood oxygen saturation (Sp O2), capillary refill time (CRT), heart rate, blood flow and CO2 emissions from skin.

The invention discloses a composition with anti-hair loss and hair development efficacy, which is prepared from the following raw materials in weight percentage: 50-60% mulberry leaf essence, 10-20% lotus seed heart essence, 20-30% forsythia essence, 1-10% orientalis leaf essence, 10-20% green tea essence, and 1-10% lactobacillus fermentation liquid. The composition of the present invention effectively exerts a synergistic effect through different raw material action mechanisms, enhances VEGF and LEFI target expression, and achieves anti-hair loss and hair development through the following two approaches: first, regulating capillary growth and local blood circulation, providing nutrition for hair follicle growth; second, promoting the proliferation and differentiation of hair follicle cells, extending the hair follicle growth cycle, inhibiting hair follicle cell apoptosis, stimulating hair follicle growth factor and consolidating new and old hair follicles, thereby achieving the effect of anti-hair loss and hair development.

According to the endoscope imaging fusion enhanced imaging method and device, imaging characteristics of white light (an overall structure background), red light (a deep blood vessel), green light (a high-contrast capillary vessel) and blue light (an enhanced surface microstructure) are comprehensively utilized, digestive tract mucosa can be analyzed in a layered mode, and comprehensive diagnosis and early focus recognition from the surface layer to the deep layer are achieved; during image fusion, adaptive weight configuration based on focus types is supported by adopting a weight dynamic adjustment mechanism, so that the quality of the finally fused image is influenced, and therefore, a neural network architecture is adopted to train each channel weight, and a more reasonable weight value can be obtained.

According to the technical scheme, the invention discloses a non-invasive pulmonary arterial pressure and capillary wedge pressure continuous estimation device which comprises a three-axis inertial sensing module, an acoustic sensing module, an electrocardio electrode module, a feature extraction module, a calibration and estimation module and an edge calculation module. Single three-axis inertial sensing and acoustic signal fusion are utilized, and the PAP and the PCWP are continuously estimated in a non-intrusive mode through a calibration regression / deep learning algorithm. According to the invention, single inertia and acoustics are innovatively taken as a collection core, and a calibration-estimation closed loop is supplemented, so that the device has the advantages of long-term continuous monitoring and real-time output of hemodynamic parameters in low-trauma, wearable and mobile environments.

The invention provides a method and system for evaluating facial skin aging, and the method comprises the steps: obtaining visible light, ultraviolet reflection and near-infrared spectrum images through multispectral imaging, and extracting skin texture, color spots and capillary network parameters through preprocessing; constructing a three-dimensional facial skin model, and measuring skin elasticity parameters in combination with a mechanical sensor; and inputting the parameters into a deep learning aging evaluation model, outputting a comprehensive evaluation report containing the physiological age of the skin, the elasticity grade and the regional aging difference index, and providing personalized aging protection suggestions. According to the method, multi-modal data and a deep learning technology are fused, multi-dimensional quantitative evaluation is realized, the method has the characteristics of high precision, objectivity and individuation, a powerful tool is provided for skin health management, and the method has a wide application prospect.

The invention provides a co-culture system of human alveolar epithelial cells and endothelial cells, which is used for researching interaction in an epithelial-endothelial barrier in lungs. It is indicated that infection with the highly pathogenic influenza A virus A / HK / 483 / 97 (H5N1) can significantly reduce alveolar fluid clearance (AFC) and increase protein permeability (APP). Administration of therapeutic extracellular vesicles (EV) after infection effectively restores AFC and APP, reduces viral replication, and enhances expression of antiviral genes. According to the invention, the treatment potential of EV is highlighted, and a valuable tool is provided for researching acute lung injury and improving a lung drug delivery technology.

The invention relates to application of roxburgh rose-derived exosomes (RrNVs) in preparation of products for preventing, improving or treating acute lung injury (ALI). Specifically, the rosa roxburghii tratt exosome (RrNVs) can effectively inhibit inflammation, improve the acute lung injury symptom, reduce the release of inflammatory cells and inflammatory mediators in the acute lung injury state, and relieve the pulmonary edema condition, the lung tissue leakage condition and the lung capillary permeability condition in the inflammatory state. Meanwhile, the RrNVs can also regulate and control the intestinal flora structure, improve the abundance of beneficial bacteria and reduce the abundance of harmful bacteria, and the discovery provides a basis for the RrNVs as potential functional food, medicine and the like of ALI.

The invention discloses a preparation method and application of an endothelium corneum gigeriae galli and angelica sinensis ointment, and relates to the technical field of traditional Chinese medicine, the endothelium corneum gigeriae galli and angelica sinensis ointment comprises the following raw materials in parts by weight: a medicine solution: 1-3g of angelica sinensis extract and 30-35 parts of endothelium corneum gigeriae An oil phase: 1-5 g of white vaseline, 1-5 g of glycerin monostearate, 10-14 g of stearic acid, 5-8 g of liquid paraffin and 3-6 g of wool fat; a water phase: 0.2 to 0.5 g of triethanolamine, 0.5 to 1 g of glycerin, and 0.1 to 0.5 g of ethylparaben; according to the endothelium corneum gigeriae galli and angelica sinensis ointment, endothelium corneum gigeriae galli and angelica sinensis materials are adopted, endothelium corneum gigeriae galli has the effects of healing sore, promoting tissue regeneration, removing blood stasis and the like, angelica sinensis has the effects of replenishing qi, enriching blood and promoting blood circulation to remove blood stasis, and skin wound healing and capillary regeneration can be effectively promoted, local blood circulation is improved, and inflammatory response is inhibited; meanwhile, the ointment is soft in texture and can absorb percolate and inhibit microbial infection; the method is convenient, economical, practical, good in stability and suitable for application and popularization.

To provide a method for manufacturing a precast residual formwork panel, which suppresses the formation of capillary voids in a precast residual formwork concrete panel body and improves the water impermeability of the precast residual formwork concrete panel body.SOLUTION: There is provided a manufacturing method of a precast residual formwork panel for use in the manufacture of a water-impermeable precast residual formwork panel, which includes: a mixing step of mixing a concrete raw material containing cement, gravel as crushed stone aggregate of limestone and sand as crushed stone aggregate of limestone with kneading water heated to a temperature of 60°C to 85°C in advance to obtain a fluidized cement composition having an as-mixed temperature of 15°C to 45°C corresponding to an outside air temperature of 0°C to 40°C; and a heat insulation curing step of naturally lowering the temperature of the fluidized cement composition to the outside air temperature without externally re-heating the fluidized cement composition charged into a forming mold so as to suppress a bleeding phenomenon in which the fluidized cement composition is discharged to the outside of the forming mold by expansion of the kneading water.SELECTED DRAWING: Figure 1

The invention relates to the technical field of medicines, in particular to application of lycium barbarum-derived extracellular vesicles in preparation of a medicine for treating acute kidney injury. The used extracellular vesicles derived from Chinese wolfberry fruits have a lipid bilayer membrane structure, are good in stability, free of remarkable toxicity, good in blood compatibility and high in-vivo safety after long-term intravenous injection, are used for preparing the medicine for treating the acute kidney injury, and can reduce apoptosis, inhibit rising of blood urea nitrogen and creatinine levels and relieve injury of kidney tissues; the invention further provides application of the extracellular vesicles derived from the Chinese wolfberry fruits in preparation of the medicine for treating the lung injury disease, the weight loss is relieved, lung tissue is protected, meanwhile, the pulmonary alveolar-capillary barrier can be repaired, and in addition, the medicine can be used for treating the lung injury disease. The invention also provides application of the extracellular vesicles derived from Chinese wolfberry fruits in preparation of nuclear transcription factor kappa B inhibitors and / or inhibition of apoptosis and / or repair of pulmonary alveolar capillary barriers.

The disclosure provides methods for analyzing two or more different proteins co-formulated in a sample mixture. The methods involve cation exchange-high performance liquid chromatography (CEX-HPLC), size exclusion ultra high performance liquid chromatography (SE-UHPLC), and / or capillary electrophoresis (CE) optimized to accurately determine the concentration, and assess certain critical quality attributes of, each protein in the sample.

The invention belongs to the technical field of biochips, and relates to a blood vessel microcirculation chip and system for in-vitro three-dimensional tissue. The blood vessel microcirculation chip of the in-vitro three-dimensional tissue comprises a chip shell component with a culture tank, an in-vitro three-dimensional tissue is arranged in the culture tank, and the in-vitro three-dimensional tissue comprises a matrix, cells in the matrix and a microcirculation vessel network in the matrix; the microcirculation vessel network in the matrix comprises a bionic artery, a bionic vein and a self-development capillary network in the matrix. The in-vitro three-dimensional tissue blood vessel microcirculation chip and system provided by the invention have bionic artery, bionic vein and capillary networks similar to organisms, and simulate the blood vessel microcirculation process of arterial high-pressure exudation mass transfer and oxygen transfer and vein low-pressure reflux metabolism.

The invention belongs to the technical field of experiments and the field of anatomical research, and particularly relates to a self-developing vascular casting agent and a preparation method thereof. The invention discloses a preparation method of a self-developing vascular casting agent. The self-developing vascular casting agent is obtained by uniformly mixing iopromide, natural latex, II-type barium sulfate and pigment, wherein in parts by weight, the iopromide accounts for 30-40%; 25%-30% of natural latex; 40% of type II barium sulfate; and 5%-10% of pigment. The blood vessel casting agent developed by the invention is excellent in formula flowability (smooth perfusion), does not cause blockage, can avoid reverse osmosis of a capillary microenvironment, and realizes arteriovenous differentiated perfusion; and meanwhile, high-contrast development is realized, and complete coverage of capillary vessels is basically realized. The optimized blood vessel casting agent formula is completely cured (at room temperature) within 24 hours, the shrinkage rate is low, and blood vessel deformation is avoided.

The invention provides a preparation method of nano traditional Chinese medicine powder, which comprises the following steps of: putting two or more than two special-shaped grinding bodies with different sizes into a ball mill, matching any special-shaped grinding body with 2-20 friction surfaces according to a weight ratio, putting materials into the ball mill, matching the special-shaped grinding bodies with the materials according to the weight ratio, and grinding the materials into a ball mill, so as to obtain the nano traditional Chinese medicine powder. Grinding in a ball mill for enough long time to obtain nano traditional Chinese medicine powder; the nano leech powder product can be prepared by the preparation method. According to the preparation method, an existing traditional ball mill is utilized, no grinding aid or dispersing agent is added, the particle size of the produced nano traditional Chinese medicine powder is controllable, the produced product does not need to be graded or subjected to impurity removal, large-batch production can be achieved at a time, and the safest and most economical effects are achieved; the nano leech powder product prepared by the preparation method can be used as an oral preparation or an injection preparation, and can directly pass through capillary walls, so that the diffusion of a medicine in a body is accelerated, and the curative effect is improved.

The present disclosure provides the use of an anti-PD-1 antibody in combination with famitinib in the preparation of a drug for treating tumors. In the present technical solution, toxicity is controllable and tolerable. At the same time, the described drug combination effectively reduces adverse reactions to the anti-PD-1 antibody, such as the occurrence of reactive capillary endothelial proliferation.

The invention discloses a pharmaceutical composition for redness removal and repair and a preparation method thereof, belonging to the technical field of skin disease treatment, which is an ointment prepared from raw materials according to the following weight ratio: 8-10 parts of chamomile, 6-12 parts of oriental rhizome, 5-10 parts of sophora flavescens, 6-12 parts of cnidium monnieri, 6-15 parts of kochia scoparia, 1-5 parts of small molecule sodium hyaluronate, 9-15 parts of ectoine, 3-10 parts of safflower, 6-12 parts of ophiopogon japonicus, 9-12 parts of mountain peony, 9-12 parts of white peony; the ointment is composed of an ointment matrix, a nanostructured lipid carrier of a Chinese medicine extract and glycerol, and the ointment matrix is ​​honey. The pharmaceutical composition for redness removal and repair finally prepared can increase the thickness of the stratum corneum, has a good healing effect on patients with persistent facial flushing and already formed telangiectasia, and can remove redness from the face.

The present invention discloses a TEP gap space creation device and its usage method, which relates to the technical field of medical auxiliary instruments. The device includes a hollow transparent tube body. The front end of the transparent tube body is formed into a wedge shape, and a conductive metal wire is transversely installed at the wedge-shaped front end. The rear end of the transparent tube body is enlarged, and a rubber ring is attached to the inner wall of the rear end of the transparent tube body along the circumference. An electrode post connected to the conductive metal wire is provided on the outer wall of the rear end of the transparent tube body. The TEP gap space creation device provided by the present invention can be sleeved outside the laparoscope during use to protect the lens from being worn. For the device provided by the present invention, its front end is provided with an electrode composed of conductive metal, which can electrocoagulate the capillaries encountered during the advancement to avoid bleeding, thereby solving the technical problem that the laparoscope lens directly contacts the tissue during the existing mirror pushing process, resulting in blurred vision.

The present application relates to a kind of wearable capillary perfusion real-time noninvasive monitoring device, including temperature acquisition module (1) and information processing module (2) connected by wireless communication, temperature acquisition module (1) includes sequentially stacked connection acquisition module top package (11), acquisition module upper layer (12), acquisition module middle package (13), acquisition module lower layer (14) and acquisition module bottom package (15), acquisition module upper layer (12) is connected with acquisition module lower layer (14) by wire (16);Temperature acquisition module (1) is directly contacted with skin above capillary, measures the temperature response of skin under heat source;Information processing module (2) analyzes temperature signal, calculates skin heat transfer coefficient by non-steady-state heat conduction principle, and then converts into skin capillary perfusion volume.Compared with prior art, the present application is small and light, suitable for wearing, suitable for real-time noninvasive monitoring of capillary perfusion under the overload condition of pilot.

The invention discloses a freckle-removing and whitening mask which is prepared from the following raw materials: chrysanthemum, pearl, radix angelicae, almond, poria cocos, rhizoma atractylodis macrocephalae, peach kernel, ginseng, mung bean, bletilla striata, cortex moutan, rhodiola rosea, silkworm larva, Chinese yam, honeysuckle and the like. The facial mask is a pure traditional Chinese medicine facial mask, has remarkable curative effects on whitening, removing freckles, removing acnes and minimizing pores, and can effectively reduce facial skin damage, effectively inhibit growth of facial germs, promote vigor of subcutaneous capillaries of the damaged face, improve metabolism of the skin and enable the facial skin to reappear in a compact and refined state. In addition, the facial mask can enhance the ability of facial skin to resist invasion and stimulation of external germs, form a natural protective barrier for the facial skin, well repair, moisten and care the facial skin, and keep the facial skin comfortable, beautiful and healthy for a long time. Pure traditional Chinese medicine raw materials are selected, chemical components are not added, and harm to facial skin and the body is avoided.

An embodiment may be a method for early diagnosis and management of varicose veins by a server, which may include the steps of acquiring varicose vein-related information from a user device, quantifying the degree of capillary exposure based on an analysis of the varicose vein-related information, evaluating the risk of varicose veins based on the quantified degree of capillary exposure, and transmitting evaluation result information for varicose veins to the user device based on the evaluated risk of varicose veins.

The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here the inventors show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases. Cd9 gene targeting in PECs prevents glomerular damage in CGN and FSGS mouse models. Mechanistically, CD9 deficiency prevents the oriented migration of PECs into the glomerular tuft and their acquisition of CD44 and β1 integrin expression. These findings highlight a critical role for de novo expression of CD9 as a common pathogenic switch driving the PEC phenotype in CGN and FSGS, while offering a potential therapeutic avenue to treat these conditions. Accordingly, CD9 represents a reliable biomarker and as well as a biotargets in glomerulonephritides.

The invention discloses an enzyme electrode method efficient blood glucose measuring device for real-time monitoring of diabetes, and relates to the technical field of blood glucose detection. The enzyme electrode method efficient blood glucose measuring device for real-time monitoring of diabetes mellitus comprises a detection box main body, a detection cavity is formed in the detection box main body, a detection opening used for stretching of the arm of a patient is formed in one side of the detection box main body, and a placement module is arranged in the detection cavity and used for bearing the arm, stretching into the detection opening, of the patient; a pressing limiting structure is arranged at the upper end of the placement module, and the bottom of the detection box main body is hollow and is provided with a supporting unit capable of being quickly opened and closed. According to the blood glucose measuring device, the blood sampling mode of the vein blood vessel of the arm of a patient is adopted to replace fingertip blood sampling, blood sampling obtained through fingertip blood sampling is capillary whole blood and contains tissue fluid, the measuring result is lower than the actual value, and the effect of venous blood sampled through the vein blood vessel is more accurate; the system is more suitable for real-time monitoring of patients in daily life.

The application belongs to the field of pharmacy, and particularly relates to a whole-process targeting polypeptide molecule with the functions of targeting brain capillary endothelial cells, tumor neovascular endothelial cells, tumor pseudo vascular, tumor cells and tumor stem cells, a stable and optimized polypeptide molecule, and a modified complex and drug delivery system for tumor diagnosis and treatment. The application prepares a whole-process targeting polypeptide WVAP and a WVAP modified drug and high polymer carrier material, and applies the WVAP to the construction of a drug delivery system for tumor imaging and targeted therapy. The results show that the WVAP can cross the blood-brain barrier, target tumor neovascular and cross the blood-tumor barrier, target tumor pseudo vascular, tumor cells and tumor stem cells; and the nano drug delivery system constructed by the WVAP modified high polymer carrier material can effectively deliver the loaded drug to the brain, target tumor tissues, and significantly improve the anti-tumor efficacy.

The utility model provides a blood vessel model fixing device aiming at the defect that an existing fixed type clamping mechanism used for clamping plastic capillary vessels cannot be used for fixing poultry embryo blood vessels with different lengths, and belongs to the technical field of medical instruments, the blood vessel model fixing device comprises a base and a blood vessel clamp, and the base comprises a fixing rod of a long-strip-shaped structure. A plurality of grooves distributed in the length direction of the fixing rod are formed in the fixing rod; the two vascular clamps capable of adjusting the distance are arranged on the fixing rod, each vascular clamp is provided with a first clamping part used for being clamped on the fixing rod and a second clamping part used for clamping a vascular model, and the first clamping part of one vascular clamp is clamped and fixed in a groove in the fixing rod. And the first clamping part on the other vascular clamp is not in the groove. The blood vessel model fixing device is simple in structure and can be used for clamping capillary blood vessel models with different lengths.

Provided are novel chiral aromatic diazatricyclo-compounds and pharmaceutically acceptable salts thereof, that are smooth muscle myosin 2 specific inhibitors useful for the treatment of ischemic events and conditions associated with capillary no-reflow, or other smooth-muscle related symptoms.