93 results about "Capillary vessels" patented technology

The invention discloses a freckle-removing and whitening mask which is prepared from the following raw materials: chrysanthemum, pearl, radix angelicae, almond, poria cocos, rhizoma atractylodis macrocephalae, peach kernel, ginseng, mung bean, bletilla striata, cortex moutan, rhodiola rosea, silkworm larva, Chinese yam, honeysuckle and the like. The facial mask is a pure traditional Chinese medicine facial mask, has remarkable curative effects on whitening, removing freckles, removing acnes and minimizing pores, and can effectively reduce facial skin damage, effectively inhibit growth of facial germs, promote vigor of subcutaneous capillaries of the damaged face, improve metabolism of the skin and enable the facial skin to reappear in a compact and refined state. In addition, the facial mask can enhance the ability of facial skin to resist invasion and stimulation of external germs, form a natural protective barrier for the facial skin, well repair, moisten and care the facial skin, and keep the facial skin comfortable, beautiful and healthy for a long time. Pure traditional Chinese medicine raw materials are selected, chemical components are not added, and harm to facial skin and the body is avoided.

The application belongs to the field of pharmacy, and particularly relates to a whole-process targeting polypeptide molecule with the functions of targeting brain capillary endothelial cells, tumor neovascular endothelial cells, tumor pseudo vascular, tumor cells and tumor stem cells, a stable and optimized polypeptide molecule, and a modified complex and drug delivery system for tumor diagnosis and treatment. The application prepares a whole-process targeting polypeptide WVAP and a WVAP modified drug and high polymer carrier material, and applies the WVAP to the construction of a drug delivery system for tumor imaging and targeted therapy. The results show that the WVAP can cross the blood-brain barrier, target tumor neovascular and cross the blood-tumor barrier, target tumor pseudo vascular, tumor cells and tumor stem cells; and the nano drug delivery system constructed by the WVAP modified high polymer carrier material can effectively deliver the loaded drug to the brain, target tumor tissues, and significantly improve the anti-tumor efficacy.

Provided are novel chiral aromatic diazatricyclo-compounds and pharmaceutically acceptable salts thereof, that are smooth muscle myosin 2 specific inhibitors useful for the treatment of ischemic events and conditions associated with capillary no-reflow, or other smooth-muscle related symptoms.

The present invention relates to a method and apparatus for determining the activity of clotting factors in diluted capillary whole blood, citrated whole blood and citrated plasma. The invention also includes the detection of hemoglobin content in the whole blood sample to correct for clotting time so that the clotting time values are not affected by hemoglobin and hematocrit.

The utility model relates to the technical field of practice teaching molds, and discloses a compression hemostasis teaching aid for adolescent emergency training, which is provided with a liquid bag, a simulated artery blood vessel, a simulated vein blood vessel, a simulated capillary and a micro pump, the liquid bag is used for storing simulated blood; the simulated artery blood vessel, the simulated vein blood vessel and the simulated capillary blood vessel are all of transparent structures and are respectively connected with the liquid bag, and the simulated artery blood vessel, the simulated vein blood vessel and the simulated capillary blood vessel are respectively connected with valves for controlling the on / off state of a pipeline; the micro pump is used for outputting pumping pressure to the liquid bag, and the pumping pressure of the micro pump is adjustable corresponding to the set flow velocity of the simulated artery blood vessel, the simulated vein blood vessel and the simulated capillary blood vessel. The first-aid training device can simulate different blood vessels of a human body and press the corresponding blood vessels to force blood flow in the corresponding blood vessels to be stopped, so that teenagers can practice operation in training, and the teaching effect of first-aid training of the teenagers is effectively improved.

In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides to treat, prevent, or reduce the progression rate and / or severity of post-capillary pulmonary hypertension (PcPH), particularly treating, preventing or reducing the progression rate and / or severity of one or more PcPH-associated complications.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

A method of measuring tissue properties using a fluid line in fluid communication with a subcutaneous tissue includes applying a pressure profile or flow profile to the subcutaneous tissue via the fluid line, with the fluid line isolated from atmospheric pressure, measuring a pressure value or flow rate value over time in response to the applied pressure profile or applied flow profile, and calculating, using at least one processor, at least one of the following: time constant of pressure decay; fluidic resistance of tissue; permeability of tissue; mechanical compliance of tissue; osmotic pressure of interstitial fluid of tissue; capillary pressure in subcutaneous tissue; and ionic strength of interstitial fluid.

The invention relates to the field of herbal fragrant moxibustion, in particular to an edible and medicinal inhalation type atomized moxibustion material and a preparation method thereof. The invention relates to an edible and medicinal inhalation type moxibustion atomized material which comprises the following raw materials in parts by weight: 8-11 parts of astragalus membranaceus, 5-6 parts of pericarpium citri reticulatae, 6-10 parts of radix puerariae, 10-12 parts of agilawood, 8-12 parts of poria cocos, 7-9 parts of radix ophiopogonis, 20-25 parts of a carrier, 2-3 parts of an adhesive and the balance of water, wherein the total weight part is 100; the carrier comprises at least one of lotus leaves and loquat leaves; the adhesive comprises at least one of guar gum and pregelatinized starch. According to the application, the medicine taking astragalus membranaceus as a main medicine is prepared into the edible and medicinal inhalation type moxibustion atomized material, and the medicine can be absorbed in an aerosol inhalation mode during use. And after the moxibustion atomized material is prepared, the medicine medium has higher penetrability, can reach blood capillaries of a human body more easily, and has a stronger conditioning effect.

The utility model relates to a colon cancer metastasis microfluidic dynamic simulation device suitable for experiment teaching, which comprises microfluidic driving equipment, a dynamic simulation module and a teaching imaging system, the dynamic simulation module comprises an invasion layer, an intestinal tract simulation layer and a blood vessel metastasis layer from top to bottom, the invasion layer is used for placing freeze-drying dyeing marked colon cancer cells, and the intestinal tract simulation layer is used for placing the blood vessel metastasis layer. The bottom of the invasion layer is composed of a capillary simulation plate for simulating capillaries, the bottom of the intestinal tract simulation layer is composed of a common blood vessel simulation plate for simulating common blood vessels, and the microfluidic driving device is connected with the input end in the blood vessel transfer layer and simulates blood flow. The teaching imaging system comprises an excitation light source for exciting the dyeing marks, a long working distance objective lens for observing the dynamic simulation module and a microscopic camera for shooting the dynamic simulation module. By adopting the scheme, the utility model provides the colon cancer metastasis micro-fluidic dynamic simulation device suitable for experiment teaching, which can observe the metastasis process in real time, has low operation complexity and is suitable for experiment teaching, so that the teaching effect is improved.

The invention discloses an air blocking plug for nasal capillary hemorrhage based on HHT, and relates to the technical field of medical auxiliary instruments, the air blocking plug comprises a support part, a fitting part and a movable part, the air blocking plug is carried out along with breathing, so that the air blocking plug is automatically generated along with breathing and alternately resists the compression of elastic frames on the two sides to the nasal cavity; at least one group of elastic frames on the two sides of the nasal septum and the two sides of the nose wings can be attached and fixed to the nasal cavity, and loosening and displacement are avoided; through the arrangement of the cotton thread, during use, water can be sucked in the cotton thread through one end of the outer bent frame, the part, making contact with the cotton thread, of the pull line is moved out of the outer side rod along with the inactivity of the pull line, water is increased for gas, damage of dry airflow is reduced, and stimulation of the airflow to blood capillaries is further relieved through the wetting effect. Meanwhile, the device belongs to a built-in type and is hidden in wearing, and the patient compliance is high.

The invention belongs to the technical field of micro-fluidic chips, and provides a micro-fluidic lung chip for simulating child lung physiological characteristics, and particularly aims at simulating specific respiratory frequencies of children at different growth stages, simulating a tissue barrier interface of pulmonary epithelium and endothelium, and simulating a fluid microenvironment. The micro-fluidic chip is mainly composed of two layers of micro-channels, the channels are separated by a polydimethylsiloxane porous membrane, two sides of each channel are respectively provided with a vacuum cavity, each layer of channel is provided with an inlet and an outlet, and a dynamic environment is formed through fluid. Lung epithelial cells and endothelial cells are respectively inoculated in the upper channel and the lower channel on the chip to form an alveolar-capillary interface on the chip. By applying negative pressure to the vacuum cavity, the respiratory frequencies of children in different growth stages are simulated. The invention provides a multi-factor participated tissue level research system for children lung diseases and children medicine research.

1. Name of the product in this design: Blood glucose meter. 2. Purpose of this design: This design is used to test the blood glucose level in fresh capillary whole blood samples. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The application provides a use of a teriparatide acetate in preparation of a medicine for preventing and / or treating acute respiratory distress syndrome, and belongs to the technical field of medicines.The application finds that after a mouse with acute respiratory distress syndrome (ARDS) is injected with the teriparatide acetate, neutrophil infiltration can be effectively reduced, and lung hemorrhage, lung capillary hyperemia and lung capillary septum thickening and other lung injury symptoms can be reduced.In addition, the teriparatide acetate can effectively prevent the occurrence of ARDS, can reduce the lung injury degree of the mouse, can reduce the neutrophil infiltration, lung hemorrhage and lung capillary hyperemia and other symptoms, can reduce the level of inflammatory factors in serum, and can reduce lung edema.Therefore, the teriparatide acetate can not only be used for treating acute respiratory syndrome and acute lung injury, but also can prevent the occurrence and development of acute respiratory syndrome, has a remarkable effect, is high in safety, and has a wide application prospect.

The present invention relates to a pathological pulmonary fibrosis model, a construction method therefor, and a use thereof. The pathological pulmonary fibrosis model provided by the present invention has good stability and controllability and high maturity, can better simulate the function and structural characteristics of the alveolar-capillary barrier, and has the pathological characteristics of pulmonary fibrosis lesions and the immune microenvironment. The model has the advantage of high simulation degree, and has good application prospects in the aspects of simulation and research of pulmonary fibrosis diseases, as well as drug detection, screening, assessment, and research and development, and the like.

The present invention relates to the field of diagnostics. Specifically, it relates to a method for assessing congestion in a subject, the method comprising the steps of determining the amount of a BMP10-type peptide (Bone Morphogenetic Protein Type 10 peptide) in a sample of the subject, and comparing the amount of the BMP10-type peptide to a reference for the BMP10-type peptide, thereby assessing congestion. The invention also considers a method for distinguishing precapillary pulmonary hypertension from postcapillary pulmonary hypertension. Further, the present invention relates to a computer-implemented method of the aforementioned method as well as to a device and a kit for implementing said method. The present invention also generally relates to the use of a BMP10-type peptide or a detection agent therefor in a sample of a subject for assessing hyperemia, or the use of a BMP10-type peptide or a detection agent therefor in a sample of a subject for differentiating pre-capillary pulmonary hypertension from post-capillary pulmonary hypertension.

Provided herein are FLT1 binding proteins, as well as related nucleic acids, vectors, host cells, pharmaceutical compositions and kits. The present disclosure additionally provides methods of treating a subject in need thereof, including subjects in need of treatment for PAD, CLI, ANOCA, or heart failure (HF). Further provided are methods of increasing VEGF-mediated and / or PlGF-mediated signal transduction in a subject, which, in turn, increases blood flow, capillary density, capillary or coronary growth, and / or cardiac perfusion in the subject. The present disclosure further provides methods of reducing blood pressure and risk of heart failure in a subject. In exemplary embodiments, each of the methods comprise administering to the subject a pharmaceutical composition of the present disclosure. In various embodiments, the pharmaceutical composition comprises a FLT1 binding protein of the present disclosure.

The invention discloses portable equipment for improving and preventing rhinitis with small-particle-size negative ions and a use method, and relates to the technical field of rhinitis prevention, the portable equipment comprises a product front shell, the equipment can release small-particle-size and high-activity negative ions by selecting an ecological negative ion generation chip technology, and the negative ions enter the nasal cavity through breathing and act on blood capillaries and nerve endings, so that the rhinitis is improved and prevented. The traditional Chinese medicine composition can regulate vasomotor, improve nasal cavity blood circulation, relieve mucous membrane hyperemia and swelling and relieve nasal obstruction, has the mucous membrane repairing function, promotes nasal mucous membrane epithelial cell regeneration, recovers ciliary movement and secretion functions, enhances the self-cleaning capacity of the nasal cavity, and can regulate whole body immunity, reduce the sensitivity of nerves to mechanical stimulation and reduce anaphylactic reactions such as sneezing. The medicine can activate the reticuloendothelial system, enhance the disease resistance of the organism, reduce rhinitis recurrence and remove environmental allergens, small-particle-size negative ions can adsorb and settle allergens such as dust mites and pollen in air, nasal cavity stimulation is reduced from the source, and double barriers for treatment and prevention are formed.

The application provides a sequential administration system for treating liver fibrosis and a preparation method and use thereof, and belongs to the field of pharmaceutical preparations. The sequential administration system for treating liver fibrosis is constructed by using a sulfonic group-SMCC to connect a polypeptide CGPVGLIGKANFLVWEIVRKKP and desialidated platelet membranes, and then embedding the desialidated platelet membranes in curcumin lipid nanoparticles to construct curcumin lipid nanoparticles AP13-Cur@DPMLip modified by the platelet membrane chimeric curcumin lipid nanoparticles of the polypeptide CGPVGLIGKANFLVWEIVRKKP. The application aims to regulate the pathological barrier of liver fibrosis, establish an efficient nanodrug delivery system, directly target KuPffer cells, sequentially break through the LSEC barrier of capillary and collagen deposition, and inhibit the activation of HSCs. Meanwhile, the interaction between curcumin and platelet membranes promotes the transformation of KuPffer cells from a pro-inflammatory phenotype to an anti-inflammatory phenotype, and finally realizes sequential targeted treatment. This sequential administration strategy provides a new way for treating liver fibrosis by targeting and regulating two key cells.

The utility model discloses a basement waterproof construction joint structure and a test device, the basement waterproof construction joint structure comprises a concrete layer 1, a concrete layer 2 and a waterproof coating layer, the concrete layer 1 and the concrete layer 2 are poured successively and form a construction joint, the waterproof coating layer is brushed in the construction joint, the construction joint is a zigzag structure, and the waterproof coating layer is coated on the waterproof coating layer. A long water seepage path is formed by the corrugated structure, the contact area with the waterproof coating layer is increased through the grooves, the cavities and the structures similar to capillary vessels formed in the water seepage path, and the water seepage prevention effect is improved; the test device comprises a test block and a test box, a sealing ring is arranged on the test block, the test block is placed in the test box, the sealing ring is attached to the interior of the test box, a connector is formed in the bottom of the test box, and in the test process of the test block, the structure of the test device can prevent the test block from moving upwards under the action of water pressure, and test conditions are guaranteed.

The invention belongs to the technical field of 3D printing materials, and particularly discloses intelligent hydrogel with an active shrinkage function and a preparation method and application thereof.The preparation method comprises the following steps that S1, 3-acrylamidophenylboronic acid is added into deionized water, and a 3-acrylamidophenylboronic acid solution is obtained; s2, tannic acid is added into the 3-acrylamido phenylboronic acid solution, and a tannic acid 3-acrylamido phenylboronic acid solution is obtained; s3, phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate and guar gum are sequentially added into the tannic acid 3-acrylamide phenylboronic acid solution, and the intelligent hydrogel with the active shrinkage function is obtained. According to the intelligent hydrogel with the active contraction function as well as the preparation method and the application, the problems of insufficient forming precision and structural resolution in an existing extrusion type 3D printing technology are solved, and a new technical path is provided for in-vitro bionic construction of fine tissues such as capillary networks and nerve microcatheters.

The invention provides a hydrogel material with an effect of supporting tissue cell growth as well as a preparation method and application thereof, and belongs to the technical field of medicines. The hydrogel material is prepared from the following raw materials: povidone, polyvinyl alcohol, agar, boric acid, edible tannin and polyacrylic resin II. The preparation method comprises the following steps: mixing the raw materials with water to obtain a mixed solution, and then carrying out a cross-linking reaction on the mixed solution through electron beam irradiation to obtain the hydrogel material with the function of supporting tissue cell growth. The hydrogel material is applied to preparation of vascular embolism agents. The hydrogel can enable a body to generate histological reaction on the hydrogel serving as a foreign body, fibroblasts wrap the hydrogel and then grow into the hydrogel, cells migrate and proliferate to form collagenous fiber tissue of a three-dimensional network structure, and then capillary and tissue cells grow into the hydrogel to form connective tissue; meanwhile, under the action that cells swallow foreign matters, the hydrogel is digested and degraded, and finally the diseased tissues are repaired.

The invention relates to application of NOTCH4 + capillary endothelial cells (NOTCH4 + CapECs) in prognosis prediction or immunotherapy effect evaluation of HBV-HCC (hepatitis B virus-associated hepatocellular carcinoma) patients, and belongs to the technical field of biomedical detection. The technical problem to be solved by the invention is to provide application of NOTCH4 + CapECs in preparation of products for predicting prognosis or immunotherapy effect of HBV-HCC patients. A tumor endothelial cell subset-NOTCH4 + CapECs is used as the integrated biomarker for the first time, meanwhile, the prognosis and immunotherapy response of HBV-HCC (especially liver cirrhosis related HCC) is associated, a product for predicting the prognosis or immunotherapy effect of HBV-HCC patients is developed, and the product is good in repeatability and high in prediction accuracy, can be used for risk stratification of the HBV-HCC patients and has a good application prospect. Individualized treatment and follow-up visit strategies are formulated in an auxiliary mode; the method is suitable for screening patients who possibly have poor benefits from immunotherapy, is also suitable for dynamically detecting and evaluating the immunotherapy effect, is used for curative effect monitoring and scheme adjustment, and has important clinical guiding significance and economic value.

The present invention aims to provide a blood collection container that prevents accidental rotation or separation of the cap, is robust and leak-resistant, and can be easily opened when necessary. [Solution] The blood collection container comprises a container body having a closed bottom portion, an open top portion, and an annular side wall portion of the container body extending between them; a cap detachable from the container body, having an open bottom portion of the cap, an open top portion of the cap, and an annular side wall portion of the cap extending between them, which is detachably inserted into the open top portion of the container body; and a lid detachably attached above the open top portion of the cap, which is sized to press-fit the cap into the container body and restricts the cap from rotating relative to the container body when fully fitted to the container body.

1. Name of the product in this design: Blood glucose meter. 2. Purpose of this design: This design is used to test the blood glucose level in fresh capillary whole blood samples. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides a sequential drug delivery system for treating hepatic fibrosis and a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The invention relates to a sequential drug delivery system for treating hepatic fibrosis, which is characterized in that sulfo-SMCC is connected with polypeptide CGPVGLIGKANFLVWEIVRKKP and an de-sialylated platelet membrane, then the de-sialylated platelet membrane is embedded in curcumin lipid nanoparticles, and the curcumin lipid nanoparticles AP13-Cur and DPMLip which are modified by the polypeptide CGPVGLIGKANFLVWEIVRKKP and embedded with the platelet membrane are constructed. The invention aims to regulate the pathological barrier of hepatic fibrosis, establish an efficient nano-drug delivery system, directly target KuPffer cells, and can sequentially break through the capillary LSEC barrier and collagen deposition and inhibit the activation of HSC, meanwhile, the interaction of curcumin and platelet membranes promotes the KuPffer cells to be converted into an anti-inflammatory phenotype from a pro-inflammatory phenotype, so that the anti-inflammatory activity of the KuPffer cells is improved, and the anti-inflammatory activity of the KuPffer cells is improved. And finally sequential targeted therapy is realized. The sequential administration strategy provides a new way for treating hepatic fibrosis by targeting and regulating two key cells.

The invention relates to the technical field of daily chemicals, in particular to a polypeptide essence formula for turning white hair into black hair and a preparation process of the polypeptide essence formula. The polypeptide essence is composed of the following components in percentage by weight: 0.5-2% of polypeptide which serves as a core component, stimulates generation of natural hair pigments and resists hair aging, and is a key for turning white hair into black hair; polygonum multiflorum is bitter, sweet, astringent and warm, belongs to liver, heart and kidney channels, has the effects of tonifying liver and kidney, benefiting essence and blood, blackening beard and hair and strengthening muscles and bones, provides nutrition for hair and assists in blackening white hair; 0.5%-2% of ginseng root extract which can expand blood capillaries of scalp and promote blood circulation of the scalp; the polypeptide essence has the beneficial effects that the polypeptide essence is safe and reliable, polypeptide and other components adopted by the polypeptide essence are natural or safe chemical substances, strict safety detection and acute oral toxicity test show that the polypeptide essence belongs to a non-toxic level, and skin irritation test shows that the polypeptide essence is non-irritating to skin and does not contain common allergy-prone components.

The present application relates to the use of a substance that regulates BCL11A gene and / or its encoded product in the preparation of a drug for reversing skin photoaging, wherein the skin photoaging includes skin cell aging caused by sunlight, light, etc., and the skin cells include keratinocytes, dermal fibroblasts, melanocytes. The regulation is to up-regulate the expression of BCL11A gene and / or promote the production of its encoded product. Typical clinical manifestations of the skin photoaging include wrinkles, dry skin, loose skin, dilated capillaries, uneven skin pigmentation, and skin itching. The substance that regulates BCL11A gene and / or its encoded product includes a substance that regulates BCL11A gene DNA molecules and a substance that regulates the expression of BCL11A translation product protein molecules. The reversal of skin photoaging is manifested in reducing the proportion of cells positive for aging-related beta-galactosidase staining in skin cells and reducing the expression of aging-related protein p16 and DNA damage protein gammaH2AX.

The invention relates to the field of cosmetology, dermatology and medicine, and is concerned with the development and production of a combination, and also of a composition based thereon, for hair growth enhancing in mammals and / or for preventing and / or treating alopecia, primarily in humans, and more particularly to combinations based on derivatives of F- and E-type prostaglandins, characterized by the absence of undesirable side-effects, and also to a stable composition comprising said combination. The use of a combination of prostaglandins in a single composition makes it possible to simultaneously activate a plurality of physiological processes, including stimulating a hair follicle to produce a new hair, increasing the local microcirculation in the area adjacent to the hair follicle, and reducing the aggregation of thrombocytes, thereby preventing thrombogenesis in the capillary network. Furthermore, the presence in the combination or in the composition based thereon of modified prostaglandins carrying a group of nitrogen oxide donors enables better penetration of other ingredients of the combination or composition into the skin.