56 results about "Vascular channel" patented technology

The inventions described in this patent application include i) a torqueable introducer sheath which is useable in conjunction with a transvascular passageway forming catheter to effect precise rotational control of the catheter; ii) an anchorable guide catheter which is useable in conjunction with an intravascular imaging catheter and a transvascular passageway-forming catheter to effect precise positioning and aiming of the passageway-forming catheter; iii) a passageway forming catheter having a torqueable proximal portion to facilitate precise rotational positioning of the distal portion of the catheter; iv) a deflectable-tipped passageway forming catheter, v) various markers and other apparatus useable in conjunction with any of the passageway-forming catheters to facilitate precise positioning and aiming of the catheter, and vi) an apparatus which may be formed within a catheter to prevent a member, apparatus of flow of material from being inadvertently advanced through a lumen of the catheter.

The invention discloses a bionic vascularized soft tissue with a multilayer vascular structure and a preparation method thereof. The preparation method comprises the steps of: employing a moulding process or 3D printing way to obtain a sacrificial membrane with a branched structure; coating or spraying a polymer solution containing a pore-foaming agent on the surface of the sacrificial membrane toobtain a polymer film; removing the treated sacrificial membrane of the structure and the pore-foaming agent to obtain a vascular channel-like structure with surface pores; conducting perfusion planting of endothelial cells in the channel of the vascular channel-like structure; planting smooth muscle cells or fibroblasts in the surface pores of the vascular channel-like structure; and placing thetreated vascular channel-like structure in a mold, adding an aquogel solution containing parenchymal cells, and conducting moulding so as to obtain the bionic vascularized soft tissue. The method provided by the invention can construct bionic blood vessels with a multilayer structure in artificial tissues.

The invention discloses a stent-type blood vessel for the intracavity treatment of a complex abdominal aortic aneurysm, which comprises a main body stent and branch stents. The main body stent is funnel-shaped. Two front wall windows are arranged on the front wall of the upper part of the main body stent and two side wall windows are arranged on the side wall of the middle part of the main body stent. Straight tube stent-type blood vessel passages are respectively and upwards arranged on the side wall windows. Each branch stent is circular-tube-shaped and the thickness of the branch stent is adaptive to the diameter of a renal artery.

A printed tissue construct comprises one or more tissue patterns, where each tissue pattern comprises a plurality of viable cells of one or more predetermined cell types. A network of vascular channels interpenetrates the one or more tissue patterns. An extracellular matrix composition at least partially surrounds the one or more tissue patterns and the network of vascular channels. A method of printing a tissue construct with embedded vasculature comprises depositing one or more cell-laden filaments, each comprising a plurality of viable cells, on a substrate to form one or more tissue patterns. Each of the one or more tissue patterns comprises one or more predetermined cell types. One or more sacrificial filaments, each comprising a fugitive ink, are deposited on the substrate to form a vascular pattern interpenetrating the one or more tissue patterns. The vascular pattern and the one or more tissue patterns are at least partially surrounded with an extracellular matrix composition. The fugitive ink is then removed to create vascular channels in the extracellular matrix composition, thereby forming an interpenetrating vascular network in a tissue construct.

Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct comprising a first vascular network and a second vascular network, each vascular network comprising one or more interconnected vascular channels; exposing the embryoid body or organoid to one or more biological agents, a biological agent gradient, a pressure, and/or an oxygen tension gradient, thereby inducing angiogenesis of capillary vessels to and/or from the embryoid body or organoid; and vascularizing the embryoid body or organoid, the capillary vessels connecting the first vascular network to the second vascular network, thereby creating a single vascular network and a perfusable tissue structure.

A method and materials to create complex vascularized living tissue in three dimensions from a two-dimension microfabricated mold has been developed. The method involved creating a two dimensional surface having a branching structure etched into the surface. The pattern begins with one or more large channels which serially branch into a large array of channels as small as individual capillaries, then converge to one or more large channels. The etched surface serves a template within a mold formed with the etched surface for the circulation of an individual tissue or organ. Living vascular cells are then seeded onto the mold, where they form living vascular channels based on the pattern etched in the mold. Once formed and sustained by their own matrix, the top of the mold is removed. The organ or tissue specific cells are then added to the etched surface, where they attach and proliferate to form a thin, vascularized sheet of tissue. The tissue can then be gently lifted from the mold using techniques such as fluid flow and other supporting material, as necessary. The tissue can then be systematically folded and compacted into a three-dimensional vascularized structure. This structure can then be implanted into animals or patients by directly connecting the blood vessels to flow into and out of the device. Immediate perfusion of oxygenated blood occurs, which allows survival and function of the entire living mass.

An object of the present invention is to provide a guidewire capable of measuring a lesion location present in a vascular channel, preventing perforation of a vessel or the like by improving flexibility of a lesion measuring part, measuring a lesion of a peripheral portion by improving insertability of the guidewire into the peripheral portion of a tubular organ such as a vessel, and accurately measuring a lesion location inside a vascular channel even under heartbeats. The guidewire includes a core shaft and a coiled body wound around a front end of the core shaft. The coiled body is made of a coil of strand. The coil of strand is formed by arranging a radiopaque coil of strand and a radiolucent coil of strand alternately in line and connecting them with each other.

The invention provides a method for manufacturing an artificial soft tissue body carried with a vascular net flow channel. The method comprises the following steps of: firstly designing a soft tissue scaffold model with a vascular structure, layering the soft tissue scaffold model one by one at equal distance, and manufacturing photomask plates of various layers; then uniformly mixing a cell and a collagen solution, and injecting a photocuring hydrogel and a photoinitiator to obtain a photocuring composite solution; injecting the photocuring composite solution to a work table, covering with the photomask plates, curing the photocuring composite solution by adopting a surface exposure technology, and then carrying out curing accumulation layer by layer to obtain a photocured hydrogel soft tissue scaffold with the vascular structure; planting vascular endothelial cells to the vascular structure of the photocured hydrogel soft tissue scaffold, wherein the vascular endothelial cells are attached to the surface of a vascular channel; carrying out static culture and dynamic culture in vitro to obtain the artificial soft tissue body carried with the vascular net flow channel. The method provided by the invention can solve the problems of survival of cells inside a large tissue engineering soft tissue scaffold, and soft tissue scaffold vessel network manufacturing and vascularization in the large injury repair of a soft tissue.

The invention relates to a traditional Chinese medicine for treating hypertension. The traditional Chinese medicine is characterized by comprising 5-10g of rehmannia glutinosa, 5-10g of dogbane leaf, 5-8g of panax psqudo-ginseng leaf, 5-8g of persimmon leaf, 10-15g of puerarin, 10-15g of herba rhodiolae, 10-15g of gynostemma, 5-8g of lotus leaf, 10-15g of angelica, 10-15g of radix paeoniae alba, 10-15g of ligusticum wallichii, 10-15g of astragalus mongholicus, 10-15g of codonopsis pilosula, 10-15g of rhizoma atractylodis macrocephalae, 5-10g of poria cocos, 5-10g of rosa cymosa tratt, 10-20g of yam rhizome, 10-15g of eucommia ulmoides, 10-15g of caulis akebiae, 5-10g of chrysanthemum, 5-10g of maythorn, 10-15g of salvia miltiorrhiza, 5-10g of mulberry leaf, 10-15g of rhizome gastrodiae, and 5-10g of ginkgo leaf. The invention researches and tests the formula of the traditional Chinese medicine for treating hypertension. By the adoption of the medicine, hypertension can be treated, side effects are small, the medicine is suitable for various groups of people, waste in a blood vessel is effectively removed, a blood vessel channel is cleaned, and the medicine has the advantages of flourishing the blood vessel, protecting or conditioning the blood vessel.

The invention relates to a device for taking out a metal bracket in a vas or a non-vascular cavity. The device comprises a phase transition energy supply device for a shape memory alloy bracket, the shape memory alloy bracket having memory effect and a control system for the energy supply device, wherein the phase transition energy supply device for the shape memory alloy bracket supplies phase transition energy to the shape memory alloy bracket to induce the memory effect of the shape memory alloy bracket having the memory effect, so as to make the shape memory alloy bracket having the memory effect recover to a shrinkage state and clasp a guide wire and a saccule; and under X-ray or CT image monitoring, the shape memory alloy bracket having the memory effect is taken out by means of an intervening instrument. The device provides a method for taking out the bracket in the vas or the non-vascular cavity, and the method has the advantages of compact and clear principle, convenient operation, safety, easy implementation, and is suitable for clinical application; and the implementation of an operation process is based on the prior mature vas or non-vascular intervening technique and has little side effect to the body.

Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses. The invention provides means of differentiating tumor cells directly into endothelial or endothelial-like cells and utilizing said cells as immunogens for the purpose of inducing immunity against blood vessels feeding tumors. In one embodiment glioma cells are cultured under hypoxic conditions in the presence of endothelial-differentiating factors. In another embodiment, PECAM-1 positive cells are derived from a tumor mass or cell line and utilized as an antigenic source to induce immunity towards tumor derived endothelial cells, endothelial-like cells, and tumor vascular channels.

The invention discloses a method of marking medical interventional equipment, and belongs to the technical field of the medical device manufacturing method. According to the medical interventional equipment labeling method, wire markers are used at the location of the interventional equipment in need of marking to closely intertwine in a same rotational direction to reach the marked length, liquid polyurethane is coated in the marked location, a first time curing is conducted, the two ends of the wire markers are cut and pressed along the curing edge, liquid polyurethane is again coated at the marked location, and a second time curing is conducted. The method of marking medical interventional equipment has the advantages that compared with the traditional laser marking and developing ring press grip, the interventional equipment does not produce any damages, the flexibility and fracture force of the original material are retained, the inner diameter of the equipment does not have any caused extrusions, the conveying of the inner diameter of the equipment is ensured to achieve the maximum size, the used materials are good in security, damages on human blood vessels and the non-vascular channels are reduced, and precision conveying of the marking of the equipment is achieved.

The invention relates to a 3D printing method of a bionic capillary network coated with multi-lamellar unit hydrogel. The method comprises the following steps: firstly, preparing hydrogel containing alamellar unit vascular channel and growth factors by utilizing a 3D printing technology, then inoculating endothelial cells into the channel, performing culturing for a period of time to obtain lamellar unit hydrogel vascular networks, then deforming and assembling the lamellar unit hydrogel vascular networks, adopting laser engraving or cutting and the like to obtain a to-be-repaired blood vessel part with a specific shape, and finally continuously performing culturing for a period of time to obtain the bionic capillary network coated with the multi-lamellar unit hydrogel. The lamellar unitvascular channel is of a planar human artery or vein blood vessel network-shaped structure and is composed of a plurality of cylindrical channels located on the same space layer or different space layers, the center distance between every two adjacent cylindrical channels is smaller than or equal to 5 mm, and the hydrogel can be invaded by endothelial cells and cells differentiated from the endothelial cells. The method disclosed by the invention is simple and feasible and has environmental universality.

The present invention provides a carrier that accumulates on a damaged tissue and that functions as a drug for controlling a platelet function, a drug delivery method using the carrier and a pharmaceutical composition comprising the carrier. The present invention also provides a carrier with a non-cationic surface, a drug transporter and a pharmaceutical composition comprising the carrier.