6 results about "Interstitial tissue" patented technology

Traditionally, the risk or progression of health conditions such as acute kidney injury (AKI) or congenital heart failure (CHF) are evaluated based on laboratory tests. While being worn by a patient, an interstitial patient monitor having a plurality of working electrodes continuously monitors a plurality of analytes in interstitial tissue of a patient. In this way, the interstitial patient monitor can promote early detection of health conditions such as AKI and CHF without laboratory tests.

This invention relates to a method for simulating the distribution of magnetofluid injection based on the coupling of particle tracking and fluid dynamics, belonging to the field of magnetic nanoparticle movement and particle tracking. The method includes: constructing a two-dimensional geometric model containing healthy tissue, abnormal tissue, and an injection syringe, and setting parameters; constructing a fluid model based on Darcy's law, and calculating the fluid velocity and pressure distribution in the interstitial tissue; coupling the fluid velocity, and solving the diffusion-convection-reaction equation using the finite element method to obtain the macroscopic concentration distribution of the magnetofluid after injection; establishing a particle tracking module, setting discrete particles with the same properties as the magnetic nanoparticles; coupling the interstitial fluid velocity, calculating the drag force and gravity acting on the particles according to Newton's second law, and simulating the particle motion to reveal the microscopic trajectory of the magnetic nanoparticles. This method, by coupling the macroscopic concentration field with the microscopic particle motion, can more realistically simulate the distribution behavior of magnetofluid within complex porous biological tissues.

The invention relates to the technical field of colorectal cancer prognosis, in particular to a colorectal cancer prognosis prediction method and system based on digital pathological image driving. Establishing a first sample data set for training a tissue subtype classification model and a second sample data set for extracting interstitial tissue samples in combination with colorectal cancer public data; training a tissue subtype classification model by using the first sample data set, extracting interstitial tissues in the second sample data set by using the trained tissue subtype classification model, and taking the extracted interstitial tissues as a third sample data set; constructing an interstitial prognosis model according to pathological block prognosis risk assessment positioning task requirements, and training the interstitial prognosis model by using the third sample data set; and extracting interstitial tissue in the pathological image of the target patient by using the trained tissue subtype classification model, and performing risk assessment positioning on the interstitial tissue in the pathological image of the target patient by using the trained interstitial prognosis model so as to perform interpretable analysis on the positioned risk area according to morphology and biology. According to the method, a clinician can be assisted to formulate a more accurate postoperative treatment scheme, and clinical transformation of a deep learning model can be accelerated.

The application discloses a brain-targeting drug delivery system based on a modified outer membrane of Escherichia coli DH5a and a preparation method and application thereof. The drug delivery system is based on specific recognition and combination between outer membrane protein A of the Escherichia coli DH5a and gp96 on endothelial cells of a blood-brain barrier, and mediates the drug delivery system to penetrate the blood-brain barrier and finally distribute in intracranial interstitial tissue. The brain-targeting drug delivery system can penetrate the blood-brain barrier to reach the brain parenchyma through a transcellular vesicular transport pathway, the preparation method is simple, the drug delivery system has good biological safety and superior delivery efficiency, and the drug delivery system has high operability and considerable economic benefits.

The invention discloses a method for culturing vascularization of interstitial-intestinal organs, and belongs to the technical field of biology. The method comprises the following steps: inducing deterministic endoderm; inducing a posterior intestinal endoderm: digesting into single cells and transferring the single cells into an agarose microarray to polymerize into balls; and inducing vascularization of intestinal organs. According to the method for realizing co-differentiation after aggregation of the agarose microarray, the size of the initial intestinal spheroid can be regulated and controlled by adjusting the size of the microarray, and the size of the initial intestinal spheroid is ensured to be consistent; by adjusting the initial cell state, the rapid growth of intestinal organs can be realized, and the growth rate of the polymerized balls is far greater than that of single cells; based on the microarray technology, the problem that the regeneration efficiency is low due to the fact that the spontaneous balling rate of a traditional method is low is solved, the extremely high effective balling rate is achieved, and the intestinal organs with more developed interstitial tissues and the higher vascularization degree are cultivated.

The invention discloses a pair of endoscopic tissue space retracting forceps which comprises a control mechanism, a first transmission mechanism, a second transmission mechanism, an elastic mechanism and a protection mechanism, the first transmission mechanism is arranged at the front end of the control mechanism, the second transmission mechanism is arranged in the first transmission mechanism, and the elastic mechanism is arranged at the front end of the control mechanism. The elastic mechanism is arranged above the first transmission mechanism, the anti-skid mechanism is arranged below the front ends of the first transmission mechanism and the elastic mechanism, and the protection mechanism is arranged at the right end of the first transmission mechanism. According to the scheme, through multiple innovative designs such as structure integration and graded buckling, breakthrough is made from four dimensions such as operation stability, the core pain point of an existing instrument is solved, meanwhile, the operation efficiency and operation experience are improved, and a safer and more efficient tissue gap retraction solution is provided for endoscope minimally invasive surgery.