38 results about "Interstitial tissue" patented technology

An autonomous active medical implantable device, with a power supply and a wake-up circuit that responds to receipt of specific pulses transmitted through the interstitial tissues of the body. A transmitter device (40) generates trains of modulated pulses applied to electrodes (22, 24), and a receiver (50) processes (e.g., filter, amplify and demodulate) pulses collected on electrodes (22′, 24′). The receiver circuits (50) are selectively activated from a dormant (sleep) state in which they are not powered by a power source (34), to an operational (active) state in which they are powered and able to process (e.g., filter, amplify and demodulate) the collected pulses. A specific wake-up pulse train, configured in a predetermined characteristic pulse pattern, triggers passive wake-up circuits (66) in the receiver (50) to switch the receiver circuits from the sleep state to the operational state.

A device for closure of an opening formed through a wall of a body vessel of a patient is provided, as well as an introducer system for delivery of the closure device. Various embodiments include the closure device having hook members configured to engage the tissue interior of the body vessel wall, hook members configured to engage interstitial tissue adjacent to the body vessel, a plug member to contact sealably the opening from inside the body vessel, and combinations thereof. A retraction member is removably attached to the each of the embodiments to permit manipulation of the device. Remodelable material may be included with each of the embodiments to promote quicker healing. The introducer includes a sheath that is insertable through the opening and a pusher disposed within the lumen of the sheath and movable within the sheath lumen to deploy the device.

Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery of genetic vectors can also be better targeted to cells where gene expression is desired. The access device comprises a cannula with a wall piercing tracar within the lumen. Two axially spaced inflatable balloons engage the wall securing the cannula and sealing the puncture site. A catheter equipped with an occlusion balloon is guided through the cannula to the location where the therapeutic substance is to be delivered.

Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery of genetic vectors can also be better targeted to cells where gene expression is desired. The access device comprises a cannula with a wall piercing tracar within the lumen. Two axially spaced inflatable balloons engage the wall securing the cannula and sealing the puncture site. A catheter equipped with an occlusion balloon is guided through the cannula to the location where the therapeutic substance is to be delivered.

An apparatus for assessing muscle quality includes a first acquisition unit that acquires bioelectric information including at least one of (i) a resistance component and a reactance component of bioelectrical impedance and (ii) first impedance measured by supplying alternating current at a predetermined low frequency to a living organism and second impedance measured by supplying alternating current at a predetermined high frequency to the living organism; a second acquisition unit that acquires a physical parameter related to physique of the living organism; and a calculation unit that calculates an index in accordance with a proportion, in muscle tissue, of muscle fiber to interstitial tissue based on the physical parameter and on at least one of a first parameter represented as a ratio between the resistance component and the reactance component and a second parameter represented as a ratio between the first impedance and the second impedance.

A device for preventing the start-up or initial operation of a vehicle, in particular of a motor vehicle, by a vehicle driver who is under the influence of alcohol, as well as a vehicle equipped with such a device. The device includes a device for determining the alcohol content in the breath, blood, tissue, sweat of the skin, or in the interstitial tissue fluid of the vehicle driver, as well as an immobilizer which prevents the start-up or the initial operation of the vehicle when the alcohol content in the vehicle driver's breath, blood, tissue, sweat of the skin, or interstitial tissue fluid, that is ascertained by the device, exceeds a specified threshold value. Means are provided for bypassing or disabling the immobilizer.

The purpose of the present invention is to provide: a non-human model animal rich in interstitial tissue; a cell structure useful for production of the non-human model animal; a method for evaluatinga test substance using the non-human model animal; and a method for producing the non-human model animal. The present invention provides a cell structure comprising biocompatible polymer blocks and atleast cancer cells and mesenchymal cells. The multiple biocompatible polymer blocks are disposed in the space between the multiple cells.

The present invention relates to a method for predicting the concentration distribution of magnetic fluid based on an injection strategy, comprising the following steps: step S1: building a geometric model of biological tissue; step S2: setting parameters and boundary conditions; step S3: simulating the fluid flow and The interstitial pressure distribution; Step S4: Simulate the spatial distribution of the fluid in the biological tissue before diffusion; Step S5: Use the coupling analysis of the velocity-concentration field to predict the concentration distribution of the fluid in the interstitium of the model tissue after diffusion. The present invention proposes three optimized injection strategies, which can finally predict the concentration distribution of the fluid after diffusion, so as to increase the effective area within the target temperature range in magnetic hyperthermia and improve the ablation effect of the target tissue.