Prediction Method of Magnetic Fluid Concentration Distribution Based on Injection Strategy

Abstract

The present invention relates to a method for predicting the concentration distribution of magnetic fluid based on an injection strategy, comprising the following steps: step S1: building a geometric model of biological tissue; step S2: setting parameters and boundary conditions; step S3: simulating the fluid flow and The interstitial pressure distribution; Step S4: Simulate the spatial distribution of the fluid in the biological tissue before diffusion; Step S5: Use the coupling analysis of the velocity-concentration field to predict the concentration distribution of the fluid in the interstitium of the model tissue after diffusion. The present invention proposes three optimized injection strategies, which can finally predict the concentration distribution of the fluid after diffusion, so as to increase the effective area within the target temperature range in magnetic hyperthermia and improve the ablation effect of the target tissue.

Description

technical field [0001] The invention relates to the technical field of nanoparticle modeling, in particular to a method for predicting the concentration distribution of magnetic fluid based on an injection strategy. Background technique [0002] Magnetic fluid hyperthermia is a heating technology that uses magnetic nanoparticles as a heating source to achieve local heating under the action of an external alternating magnetic field to ablate target tissues with high temperature sensitivity. Because it produces few side effects and is less invasive to extraneous tissues, it is considered to be a highly potential heating method because of its significantly improved ablation effect compared with other modalities. Studies have shown that when the temperature is between 42°C and 46°C, the target tissue is damaged due to its sensitivity to high temperature, but the unrelated tissue is more likely to be unaffected. [0003] The research on magnetic hyperthermia involves many fields...

AI Technical Summary

Problems solved by technology

Studies have shown that when the temperature is between 42°C and 46°C, the target tissue is damaged due to its sensitivity to high temperature, but unrelated tissue is more likely to be unaffected

[0003] The research on magnetic hyperthermia involves many fields. Because of its excellent ablation effect, it has attracted extensive attention from researchers, but there are still many obstacles to be overcome for it to be put into use.

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