Magnetofluid concentration distribution prediction method based on injection strategy

Abstract

The invention relates to a magnetofluid concentration distribution prediction method based on an injection strategy. The method comprises the following steps of S1, constructing a geometric model of a biological tissue, S2, setting parameters and boundary conditions, S3, simulating flow of fluid in the model and interstitial substance pressure distribution of the fluid, S4, simulating spatial distribution of the fluid in the biological tissue before diffusion, and S5, predicting the concentration distribution of the diffused fluid in the interstitial substance of the model by using coupling analysis of a speed-concentration field. According to the method, three optimal injection strategies are provided, and finally, the concentration distribution after fluid diffusion can be predicted, so that the effective area in a target temperature range in magnetic hyperthermia is increased, and the ablation effect of target tissues is improved.

Description

technical field [0001] The invention relates to the technical field of nanoparticle modeling, in particular to a method for predicting the concentration distribution of magnetic fluid based on an injection strategy. Background technique [0002] Magnetic fluid hyperthermia is a heating technology that uses magnetic nanoparticles as a heating source to achieve local heating under the action of an external alternating magnetic field to ablate target tissues with high temperature sensitivity. Because it produces few side effects and is less invasive to extraneous tissues, it is considered to be a highly potential heating method because of its significantly improved ablation effect compared with other modalities. Studies have shown that when the temperature is between 42°C and 46°C, the target tissue is damaged due to its sensitivity to high temperature, but the unrelated tissue is more likely to be unaffected. [0003] The research on magnetic hyperthermia involves many fields...

AI Technical Summary

Problems solved by technology

Studies have shown that when the temperature is between 42°C and 46°C, the target tissue is damaged due to its sensitivity to high temperature, but unrelated tissue is more likely to be unaffected

[0003] The research on magnetic hyperthermia involves many fields. Because of its excellent ablation effect, it has attracted extensive attention from researchers, but there are still many obstacles to be overcome for it to be put into use.

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