156 results about "Tissue Model" patented technology

The invention discloses an AI-based neurosurgery auxiliary robot visual positioning system, and relates to the field of visual positioning, which comprises the steps of deploying and initializing structured light scanning equipment and near-infrared imaging equipment, carrying out multi-modal image acquisition on a surgical area, and carrying out standardization processing, space-time alignment and fusion on the acquired image. A multi-modal visual acquisition and preprocessing module, a three-dimensional tissue model construction and registration module, a visual-anatomical feature recognition and extraction module, an AI auxiliary positioning and path optimization module, an intraoperative dynamic perception and feedback control module and a target position confirmation and instruction output module are constructed. According to the method, high-precision identification and dynamic modeling of a brain tissue structure are realized, real-time identification, path planning and position correction can be carried out on a key anatomical structure in an operation process, the precision, the intelligent level and the intra-operation response capability of neurosurgery operation are remarkably improved, the operation risk is effectively reduced, and the positioning reliability and the automatic control efficiency are improved.

Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

The invention discloses a man-machine cooperation type high-precision acupuncture method and system based on digital twinning, and relates to the technical field of acupuncture, and the method comprises the steps: obtaining user body surface image data, local subcutaneous tissue structure data, standard meridian model data and real-time electrophysiological data; generating a three-dimensional point cloud model based on the body surface image data, and mapping the standard meridian model data to the three-dimensional point cloud model to generate initial acupuncture point coordinates; dynamically correcting the initial acupuncture point coordinates based on the real-time electrophysiological data to obtain individualized acupuncture point coordinates; constructing a hierarchical tissue model containing neural distribution based on the local subcutaneous tissue structure data; the method has the advantages that dynamic acupuncture point correction is achieved by fusing three-dimensional point cloud modeling and real-time electrophysiological feedback, a precise acupuncture path is generated in combination with nerve activation probability prediction, real-time path adjustment is conducted based on physiological feedback, and the method has the advantages of improving acupuncture point positioning precision, achieving dynamic optimization of the acupuncture path and improving treatment safety.

Embodiments of the invention include additional methods and compositions for fabricating organoids. A unique approach has been developed for the rapid aggregation of defined number of cells using a micropillar-based template to limit the size of organoids, which are then more commonly referred to as spheroids. This procedure can be utilized to create in vitro cardiac tissue models (e.g., cardiac organoids) simply, rapidly, and inexpensively. In certain aspects an alginate-gelatin based hydrogel premixed with cardiomyocytes is used in combination with a patterned microfluidic chip / cell culture chamber having an array of micropillars to fabricate 3D cardiac organoids.

A reinforcing and scaling construction for a bioprinted tissue model, which comprises a casing and sealing bioink, the casing comprising an inner module comprising a casing base (1) and a perforated cover (2), and an outer module comprising a container (3) comprising technological valves (5), an outer cover (4) and plugs (6) for technological valves (5). The invention also relates to a method for assembling the reinforcing and sealing construction.

Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.

The invention discloses a control method, system and equipment of an intelligent throat surgical robot and a medium. According to the scheme, a three-dimensional tissue model is constructed according to visual image data, laser imaging data and tomography image data; determining lesion data according to the historical lesion data and the tomography image data, superposing the lesion data and the three-dimensional tissue model, and determining a target operation model; determining prediction trajectory data according to the tomography image data and the physiological motion data; planning a path according to the predicted trajectory data, the target operation model and the constraint condition, and controlling the operation robot to perform an operation according to the planned path; through multi-modal data fusion, a three-dimensional tissue model is established to improve the surgical accuracy; the data are analyzed to determine the lesion direction, the motion trail of the organ tissue is predicted, the three-dimensional tissue model is integrated for path planning, the interference of physiological activities of the organ tissue on the operation is avoided, and the safety of the operation is improved. The embodiment of the invention can be widely applied to the field of intelligent robots.

The invention relates to the technical field of neurosurgical intelligent operations, and discloses a neuroendoscopic surgery intelligent puncture positioning system based on image navigation, and the system comprises a preoperative modeling module which constructs a preoperative tissue model and a corresponding elastic tensor field based on a three-dimensional medical image of a patient; the image fusion module is used for receiving the data of the preoperative modeling module, collecting intraoperative endoscopic images, predicting the tensor disturbance of tissues through a deep learning model, and feeding back the updated tensor disturbance to the tensor updating module; and the tensor updating module is in two-way communication with the image fusion module and is used for superposing tensor disturbance obtained by processing the intraoperative image with the preoperative tensor. Through fusion of an image navigation technology and preoperative modeling, a three-dimensional positioning frame based on neuroendoscopy operation requirements is constructed, intelligent planning and real-time correction of a puncture path are realized, important brain regions and vascular structures are effectively avoided, intra-operative risks are reduced, and positioning precision and safety are improved.

The invention discloses a near-field focusing microwave thermal therapy device and method based on a Huygens metasurface. The device comprises a feed source antenna, a Huygens metasurface array and a biological tissue model. The feed source antenna is a 5.8 GHz double-ridge horn antenna and is used for transmitting x-polarized electromagnetic waves; the Huygens metasurface array is formed by periodically arranging double-layer through-hole-free Huygens units, anti-symmetric E-shaped metal patterns are symmetrically arranged on the upper surface and the lower surface of the single-layer PCB substrate, and phase regulation and efficient transmission are achieved by adjusting unit structure parameters; the biological tissue model is of a two-layer structure attached to the Huygens metasurface array, electromagnetic waves emitted by the feed source antenna are subjected to phase compensation regulation and control through the Huygens metasurface array, and then near-field focusing is achieved on the surface layer of the biological tissue, so that the electric field intensity, the SAR value and the temperature of a target area reach design threshold values respectively, and the target area is obtained. And local precise heating of electromagnetic resonance and phase regulation is formed. According to the invention, an efficient, stable and easy-to-implement technology is provided for local precise heating in microwave hyperthermia.

A method of diagnosing a condition of bodily tissue using a computer, the method comprising comparing, using a computer, a 3D tissue model derived from an ultrasound scan of the bodily tissue with at least one 3D tissue model having common tissue with the bodily tissue, and diagnosing a condition of the bodily tissue responsive to comparing the 3D tissue models.

According to the three-dimensional electric field coupling modeling method for analgesia provided by the invention, the propagation process of an electric field in each physiological tissue is accurately simulated by constructing a multi-layer bionic tissue model, so that the accuracy and effect of analgesia treatment are improved; calculating the conductivity and dielectric constant of each layer of tissue, performing numerical simulation on electric field distribution by using a finite element analysis technology, optimizing electrode configuration and electrical stimulation parameters, and ensuring the uniformity and stability of the electric field of a target area; a neurophysiology model is integrated, the conduction law of nerve fiber action potential is dynamically simulated, the stimulation effect of electric field intensity on nerve fibers is quantitatively analyzed, analgesia parameters are further optimized, and accurate control over pain signal transmission is achieved. The problems that in an existing electrical stimulation technology, electric field distribution is not uniform, electrode contact is not stable, and the stimulation effect is difficult to last are effectively solved, wide clinical application prospects are achieved, and an efficient, stable and accurate solution is provided especially in non-invasive treatment of chronic pain.

Systems and methods are disclosed for using patient-specific anatomical models and physiological parameters to predict viability of a target tissue or vessel to guide diagnosis or treatment of cardiovascular disease. One method includes: receiving a patient-specific vessel model and a patient-specific tissue model of a patient anatomy; receiving one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, etc.) for one or more physiological states; estimating a viability characteristic of the patient-specific tissue or vessel model (e.g., via a trained machine learning algorithm), using the patient-specific physiological parameters; and outputting the viability characteristic to an electronic storage medium or display.

A heart organoid of at least 60% cardiac cells irrespective of optional additional cells of a vascular system of the organoid, or including at least 50% cardiac cells; wherein the cardiac cells surround an inner cavity, wherein the cardiac cells are selected from the group of cardiomyocytes, endocardial cells and epicardial cells, and wherein the heart organoid includes cardiomyocytes or endocardial cells that directly face the inner cavity, a method for the generation of such a tissue model and uses thereof.

The present invention relates to a method for producing a skin tissue model, comprising: (a) isolating and culturing fibroblasts and keratinocytes from skin tissue; (b) preparing a bioink composition for a dermal layer and a bioink composition for an epidermal layer, the bioink composition containing the isolated cells; and (c) producing a skin tissue model using the bioink composition for a dermal layer and the bioink composition for an epidermal layer.

The invention relates to a system for storing or cultivating organ or tissue models and its use. The system is designed for verifying the functionality of the harvested organ or tissue models and allowing them to be processed. The system can be used for cultivating organ and / or tissue models harvested from donors and / or prepared using other techniques, such as using 3D and / or 4D bioprinting or electrospinning techniques, and comprises a chamber (2) for the organ or tissue models, which is equipped with means for measuring and adjusting the temperature of the perfusion liquid in the chamber, a perfusion liquid container (1), which is equipped with means for measuring and adjusting the temperature of the perfusion liquid therein, means (4) for measuring the glucose concentration in the perfusion liquid and adding glucose to the perfusion liquid in a metered amount, means (3) for measuring the pH of the perfusion liquid and adding a substance for adjusting the pH of the perfusion liquid in a metered amount, means for non-contact mixing of the perfusion liquid, and means for measuring and controlling the flow parameters of the perfusion liquid.

The present invention relates to a method for functionalizing a biopolymer having an -OH group or an -NH2 group by reacting the biopolymer with at least one compound having at least one C=C bond or C≡C bond and containing a chromophore that absorbs UV-Vis radiation directly adjacent to this bond. The present invention also relates to a method for obtaining a solid biopolymer material by reversibly crosslinking the functionalized biopolymer obtained by the above method under UV-Vis light irradiation. Furthermore, the present invention relates to the use of functionalized biopolymers as support materials for 3D bioprinting, or as materials for manufacturing structures selected from spheroids, organoids, artificial organs, coatings, and tissue models.

The present application provides a medical imaging coordinate correction system based on a geodetic coordinate system, comprising a fixed box, and a swingable coordinate system tube, which is connected to the fixed box and contains a contrast agent; the fixed box is also provided with a rotatable calibration plate, which is provided with a cross mark, and the coordinate system tube is connected to the calibration plate; a rotatable display board rack is also provided, which is used to fix a tissue model, and the display board rack is provided with an inclination sensor, which solves the problem of poor coordinate system correspondence and difficult quantitative feedback of the angle value of the physical model when the virtual imaging model is converted into a physical model.

The invention provides a thoracic surgery teaching assistance method and system, and the method comprises the steps: constructing a thoracic surgery virtual operation interaction environment based on a digital twin technology, and endowing a virtual thoracic cavity tissue model with initial biomechanical parameters; an operation instruction data sequence of an operator for the virtual surgical instrument is collected in real time through the man-machine interaction interface; based on the operation instruction data sequence, calculating an operation disturbance characteristic index representing the motion dispersion degree of an operator in real time by using a sliding time window algorithm; establishing a dynamic evolution mapping model of an operation disturbance characteristic index and a biomechanical parameter, dynamically correcting an initial biomechanical parameter of the virtual tissue according to the index calculated in real time, and when the index exceeds the standard, controlling the parameter to deviate to an easily damaged state so as to simulate histopathologic change caused by rough operation; and performing physical collision response calculation and three-dimensional picture rendering according to the evolved model. According to the invention, dynamic coupling of operation behaviors and organization characteristics is realized, and the physical reality sense of teaching is improved.

The invention relates to the technical field of medical simulation, in particular to an ablation needle puncture training auxiliary system, and aims to solve the problems of insufficient tactile feedback and low fineness when an existing ablation needle puncture training system simulates a needle tip to penetrate through multiple layers of biological tissues so as to improve the'needle feeling 'cognition and fine operation skills of doctors. The system is characterized by comprising a physical interaction module, a virtual simulation module, a central processing module and a visual presentation module, a high-fidelity virtual tissue model is constructed, real-time multi-mode tactile feedback is combined, and an accurate needle-tissue interaction mechanical simulation and multi-dimensional tactile rendering algorithm is adopted. By the adoption of the technical scheme, the problem of a touch gap is effectively solved, the authenticity and effectiveness of simulation training are improved, and the precision and safety of clinical puncture operation are remarkably improved.

The application discloses a simulation-based respiratory displacement prediction method and device, a surgical robot, and an electronic device. The method comprises the following steps: obtaining a first three-dimensional model of a first object, wherein the first three-dimensional model comprises a first tissue model, and the first tissue model is a model of a first tissue in the first object; determining a first relationship of the first tissue model based on stress characteristics of the first tissue, wherein the first relationship is a relationship between a force received by the first tissue model and a deformation of the first tissue model; obtaining a first simulation force, wherein the first simulation force is used to simulate a respiratory force on the first tissue; and determining a first respiratory displacement of the first tissue based on the first three-dimensional model, the first relationship and the first simulation force, wherein the first respiratory displacement is a displacement generated by respiration of the first object. According to the method provided in the application, the first respiratory displacement of the first tissue can be determined by simulating the movement of the first tissue in the respiration process of the first object, and thus the accuracy of the first respiratory displacement can be improved.

A multi-cell barrier tissue model of a bionic sequential development mechanism has a multi-layer multi-cell structure simulating a physiological barrier, related cells of different barriers are distributed in different layers according to the physiological structure, and the development time and sequence of the cells of different layers are regulated and controlled according to natural barrier multi-cell development physiological characteristics; the multi-cell three-dimensional structure of in-vivo barrier tissue can be simulated, regulation and control of cell development behaviors are achieved by regulating and controlling the matrix environment, and meanwhile, the model has enough overall mechanical support through the soft / hard chimeric structural design so as to adapt to perfusion culture and operation requirements; the model can realize functional bionics of natural barrier tissues at the same time in the spatial structure dimension and the time development dimension so as to realize application in the aspects of disease modeling, drug screening and the like.

The invention belongs to the technical field of image processing, and discloses a hepatobiliary calculus surgery image navigation and positioning system, which is configured to realize non-rigid registration of adaptive multi-stage fusion, dynamically adjust registration weights of surface and deep features according to environmental changes in surgery, and realize image navigation and positioning of the hepatobiliary calculus surgery. It is ensured that a continuous high-precision dynamic three-dimensional model is provided in the whole process; predictive virtual tactile feedback based on biomechanical simulation is realized, and tissue tension perception and damage early warning beyond real tactile sense are provided for doctors by calculating stress and strain of a tissue model in real time; the intelligent quantification of the stone residual risk based on multi-source information fusion is realized, and the stone residual risk is quantified and visualized with high confidence by fusing the surgical operation history and the intraoperative fluorescence function image. According to the invention, a closed-loop navigation platform integrating high-precision environment perception, predictive process control and intelligent result quality control is constructed, and the precision and safety of auxiliary tools for minimally invasive surgery of hepatic duct calculi are improved.

A biochamber containing a flow system, characterized in that it consists of two modules: a) an internal module, containing a base (1) and a cover (4) of the biochamber, equipped with - respectively - a first window (2) and a second window (5); a seal and two luer lock connectors (10); b) an external module, containing a first frame (7), a second frame (8) and fasteners (9).

The application discloses a gene editing system for constructing a muscle weakness disease model pig nuclear transfer donor cell with a DOK7 gene mutation and application thereof. The application provides application of DOK7-gRNA2 shown in SEQ ID NO: 16, DOK7-gRNA4 shown in SEQ ID NO: 17 and NCN protein in preparation of a kit. The application further provides a method for preparing a recombinant cell, comprising the following steps: co-transfecting a pig cell with DOK7-gRNA2, DOK7-gRNA4 and NCN protein to obtain a recombinant cell. The recombinant cell is a recombinant cell with a mutated DOK7 gene. The use of any of the above kits is to prepare a recombinant cell, to prepare a muscle weakness model pig, to prepare a muscle weakness cell model, a muscle weakness tissue model or a muscle weakness organ model. The application has great application value for research and development of muscle weakness disease drugs and revealing the pathogenesis of the disease.

The system is designed to verify the functionality and enable handling of excised organ or tissue models, which may be used to culture excised organ or tissue models from donors and / or organ or tissue models made using other techniques such as 3D and / or 4D bioprinting or electrospinning, and comprises a chamber for the organ or tissue model with means for measuring and regulating the temperature of the internal perfusate, a perfusate container with means for measuring and regulating the temperature of the internal perfusate, means for measuring the glucose concentration of the perfusate and administering glucose to the perfusate, means for measuring the pH of the perfusate and administering a substance to adjust the pH of the perfusate, means for non-contact mixing of the perfusate, and means for measuring and controlling flow parameters of the perfusate.

The invention relates to the technical field of shear wave elastography, in particular to a shear wave elastography optimization processing system which comprises a data acquisition module, a fusion analysis module and an output control module. The system obtains shear wave propagation data and auxiliary detection data, extracts tissue characteristic parameters and performs grouping processing, constructs a compensation function by using a weight coefficient to optimize a characteristic distribution interval, and generates a tissue model based on a three-dimensional modeling technology to realize high-precision imaging of a complex tissue environment. According to the invention, imaging precision, real-time performance and operation convenience can be effectively improved, algorithm complexity is reduced, and stability and adaptability of the system are enhanced.

The application discloses a heart soft tissue model correction method and device based on a physical information neural network, and comprises the following steps: acquiring preoperative images to construct a personalized heart biomechanical model and an active motion priori library; constructing a double-flow coupled physical information neural network, which comprises an active deformation prediction branch for predicting heart autonomous beats and a passive residual correction branch for correcting deformations caused by external contact forces; defining a loss function comprising a data matching loss and a biomechanical control equation loss, and training the network; receiving in-surgery collected cardiac phase data and sparse surface displacement data, inputting the data into the trained network, and outputting a global three-dimensional deformation field to update a preoperative three-dimensional model. The application effectively decouples the active and passive mixed deformation of the heart through a double-flow coupled architecture, and can infer the full-field volume deformation by only using sparse surface observation points by embedding physical control equations as strong constraints, thereby overcoming the data sparsity problem.

The present application relates to a boron neutron capture therapy system (100) and a method of operating the same, the boron neutron capture therapy system (100) including a neutron beam irradiation device (10), a treatment planning module (30), and a control module (40), wherein the neutron beam irradiation device (10) generates a neutron beam and irradiates the neutron beam to an irradiated body, the treatment planning module (30) sets a boron concentration for each voxel unit in a three-dimensional voxel prosthetic tissue model to generate a treatment plan, and the control module (40) controls the neutron beam irradiation device (10) to irradiate based on the treatment plan. The treatment planning module (30) sets corresponding boron concentration data for each voxel unit, and then combines it with medical image data to perform dose simulation to formulate a treatment plan, thereby making the distribution of boron atoms in the region of interest more consistent with the actual situation, improving the accuracy of model establishment and dose calculation, and ensuring the accuracy of the treatment plan, thereby guaranteeing the treatment effect.

The invention relates to a method for planning an intraoral treatment for a patient. A three-dimensional digital tissue model of intraoral tissue of the patient's oral cavity comprising maxillary and mandibular tissue is received. A maximum mouth opening value is received. Relative positions of the maxillary and mandibular tissue relative to each other are determined for a maximum mouth opening of the patient using the maximum mouth opening value. Size information of one or more treatment elements selected to be used for executing the intraoral treatment are received. A three-dimensional working space required for arranging and using the one or more selected treatment elements for executing the intraoral treatment is determined using the size information of the one or more selected treatment elements.

A three-dimensional (3D) lymphoid tissue model is provided, the model including a cellularized stromal compartment and a plurality of cellularized compartments including lymphocytes disposed within the stromal compartment; and a controlled fluid perfusion system configured to perfuse the model with a perfusion fluid. Methods of fabricating a 3D lymphoid tissue model and producing antibodies with the 3D lymphoid tissue model are also provided.