234 results about "Tissue Model" patented technology

A method of controlling a penetrating member is provided. The method comprises providing a lancing device comprising a penetrating member driver having a position sensor and a processor that can determine the relative position and velocity of the penetrating member based on measuring relative position of the penetrating member with respect to time; providing a predetermined velocity control trajectory based on a model of the driver and a model of tissue to be contacted. In some embodiments, a feedforward control to maintain penetrating member velocity along said trajectory.

An implant analog is for supporting an article that is used to develop a dental prosthesis. The analog provides a main body for being anchored in a model of a mouth of a patient. The main body includes an upper surface for contacting the article that is used to develop a dental prosthesis. The analog includes a groove extending inward along a periphery of the main body below the upper surface for receiving a soft modeling material that replicates gingival tissue. Material for forming a soft tissue model flows into the groove to create a corresponding rib in the soft tissue model that allows the soft tissue model to be properly registered on the underlying stone model.

This invention introduces an oral-dental anatomy modeling method and an implant treatment planning system based on a full anatomy model (FAM). Dental Implant Treatment Planning systems place implants on 2D slices of DICOM files, and sometimes on 3D models of bones and remaining teeth. Because the final look and feel of implants and restorations depend on how well they go along with the remaining teeth and soft tissues, treatment planning without tissue model presents safety and aesthetics risks. A FAM consists of models for bones, teeth, soft tissues and nerves. They are created from CT and optical scans, and assembled together with model registration techniques. The tissue model is the real differentiator. A treatment planning system uses FAM as a unique reference throughout the workflow. Its implant placement, restoration preview and surgical guide design are all based on FAM.

Disclosed is a cervico-vaginal tissue equivalent comprised of vaginal epithelial cells and immune cells, cultured at the air-liquid interface. The tissue equivalent is capable of being infected with a sexually transmitted pathogen such as a virus (e.g., HIV), a bacteria, a helminthic parasite, or a fungus. The tissue equivalent is also capable of undergoing an allergic-type reaction or an irritant-type reaction. The tissue equivalent is characterized as having nucleated basal layer cells and nucleated suprabasal layer cells, and further as having cell layers external to the suprabasal layer progressively increasing in glycogen content and progressively decreasing in nuclei content. Immune cells of the tissue equivalent are primarily located in the basal and suprabasal layers. Also disclosed are methods for producing the tissue equivalent. The methods involve providing vaginal epithelial cells and immune cells, seeding the cells onto a porous support, and co culturing the seeded cells at the air-liquid interface under conditions appropriate for differentiation. One such method disclosed is for generation of the tissue equivalent in serum free medium. Specific cells from which the tissue equivalent is generated, and also specific preferred components of the medium in which the tissue equivalent is generated are provided. Also disclosed is a cervico-vaginal tissue equivalent produced by the methods disclosed herein.

A method of making a tissue model comprises determining one or more material properties of a tissue, wherein the one or more material properties include at least one of mechanical properties, electroconductive properties, optical properties, thermoconductive properties, chemical properties, and anisotropic properties, creating an anatomical structure of the tissue, selecting an artificial tissue material having one or more material properties that substantially correspond to the one or more material properties of the tissue, and coupling the artificial tissue material to the anatomical structure.

The invention discloses an audio processing method for a bone conduction headset, the bone conduction headset and an audio playback device based on the bone conduction headset. The bone conduction headset comprises a human bone and tissue model modeling module, a digital pre-corrector, a delay estimation unit, a digital-to-analog converter, an analog-digital converter, a first low-pass filter, a second low-pass filter, an audio amplifier, an audio driving amplifier, at least one bone conduction microphone, and at least one bone conduction vibrator. In the method, human bone and tissue attenuation effect information of different users is detected in real time; a compensating transfer function is generated based on the attenuation effect information; and an input audio signal is subjected to digital pre-correction via the compensating transfer function, and then the processed input audio signal is transmitted in human bones and tissues. Through adoption of the method, a problem that experience of the bone conduction headset is different caused by different tissue thickness of the different users is solved.

A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided.

The invention discloses an acetabulum tissue model reconstruction method for a serialization hip joint CT image. The method includes the following steps of forming a fine outline, wherein the point with the maximum gradient on the vertical line of the tangent line of any point on a circular caput femoris coarse outline on a selected original CT slice is selected; traversing the caput femoris coarse outline to obtain an outline point set of the points, with the maximum gradient, on the vertical lines of all the tangent lines; connecting the points in the outline point set to form the fine outline of the caput femoris tissue of the CT slice; extracting a sequence caput femoris outline; extracting a sequence acetabulum image; conducting three-dimensional reconstruction. According to the method, personalized related position parameters are obtained on the basis of the individual hip joint bone shape of a patient, acetabulum segmentation is conducted in the CT image to obtain accurate acetabulum tissue images and a three-dimensional model, the foundation is laid for conducting personalized reverse determination modeling on an artificial caput femoris prosthesis in the subsequent process, no priori knowledge obtained by conducting training on other data sets is needed, and implementation is easy.

The present invention provides for an engineered three dimensional (3D) pulmonary model tissue culture which is free of any artificial scaffold.

The invention belongs to the field of optical parameter measurement in tissue optics research, in particular to an optical parameter reconstruction method based on frequency-domain near-infrared photoelasticimetry. The optical parameter reconstruction method comprises the following steps of: positively modeling by utilizing a time-domain Monte Carlo simulated biological tissue model; and extracting frequency-domain information by utilizing a fast formula; acquiring frequency-domain information under any optical parameter by adopting a rapid MC (Multiple-Carrier) module based on a binary polynomial to achieve the aim of accurately reconstructing the optical parameters of tubular tissue by integrating an L-M (Levenberg-Marquardt) optimization algorithm and improve the reconstruction accuracy by introducing a cluster analysis method. The invention has the advantages of simultaneously reconstructing an absorption coefficient and a scattering coefficient of tissue and reconstructing the speed and the accuracy and can be used for accurately predicting the optical parameters of a measured sample in real time by the measured frequency-domain information, i.e. the amplitude and the phase (A, phi).

A computer-aided positioning and navigation system for dental implant includes a computer system having built therein a dental implant planning software and providing a 3D digital human tissues model to create an implant navigation information, a positioning assistive device including a body providing a positioning portion and a guide portion and a connection member carrying an optical positioning device, one or multiple optical capture devices, and a display device electrically connected to the computer system. The computer system controls the optical capture device to capture images and drives the display device to display a part of the content of the 3D digital human tissues model and the implant navigation information.

A method for making a jet injection drug delivery device wherein the drug delivery device has at least one drug reservoir and at least one injection nozzle includes the steps of: identifying a drug desired to be delivered; identifying a volume of the drug desired to be delivered; establishing a reservoir diameter for the at least one drug reservoir; establishing a nozzle diameter for the at least one injection nozzle; identifying a tissue model for delivery of the drug; identifying a penetration depth in the tissue model for the delivery of the drug; and injecting the drug into the tissue model under variable pressure until the desired penetration depth is achieved. The method also includes identifying an optimal pressure range for the drug delivery device that achieves the desired penetration depth.

The invention belongs to the radiation dose monitoring technology, and specifically relates to a monitoring method and device for measuring effective dose on real time. The method comprises the steps of manufacturing a simulated human organ or tissue model; performing monte carlo simulation calculation through a computer to obtain absorbing dose of a plurality of points in the organ or tissue model so as to obtain an average value; finding out the points in which the absorbing dose is the same as the calculated average value in the organ or tissue model; arranging a detector on the points corresponding to the organ or tissue model, wherein the measurement result represents the average absorbing dose DT, R of the organ or tissue; calculating the effective dose for a human body by the calculation formula of the effective dose E according to the weight factor wT of the organ or tissue and the selected value of the radiation weight factor wR. With the adoption of the method and the device, the effective dose for workers can be directly measured, and thus the radiation protection can be conveniently optimized.

A polymeric chip having at least one three-dimensional porous scaffold, a microfluidic channel inlet to the porous scaffold, and a microfluidic channel outlet from the porous scaffold. In one embodiment, the polymeric chip has two three-dimensional porous scaffolds: one scaffold comprises liver cells and the other scaffold comprises cancer cells. The chip can be used as a multi-organ tissue model system.

The invention relates to the use of CD14⁺ monocytes for the production of dendritic cells.

The invention comprises the use of CD14⁺ monocytes isolated from peripheral circulating blood for obtaining, by differentiation, at least one mixed population of Langerhans cells and interstitial dendritic cells, both Langerhans cells and interstitial dendritic cells being preconditioned and undifferentiated, and/or differentiated and immature, and/or mature, and/or interdigitated. The invention comprises their use in suspension, monolayer and three-dimensional cell and tissue models. The invention comprises the use of these cells and of these models as study models for the assessment of immunotoxicity/immunotolerance, for the development of cosmetic and pharmaceutical active principles and for the development and implementation of methods of cell and tissue therapy.

A synthetic eye model includes an enclosed lens capsule, a removable cortex material within the lens capsule, and an outer support for the lens capsule. A synthetic eye model assembly includes an eye segment comprising a lens capsule and an outer support and a base for detachably engaging the eye segment. The synthetic eye model and assembly can be made by 3D printing. A method of practicing eye surgery and a method of making a three-dimensional synthetic tissue model of an anatomical tissue structure are also disclosed.

Methods, systems, and related computer program products for the non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers are described. Aggregate absorption and scattering properties are measured for each of a plurality of predetermined source-detector separation distances along a surface of the biological volume, the measurement being based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume. A predetermined multi-layer tissue model is retrieved that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured at selected source-detector separation distances along a surface thereof. The measured aggregate absorption and scattering properties are processed in conjunction with the predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer.

The present disclosure describes systems and methods for mimicking body tissue and the function thereof. The mimicked body tissue can include kidney tissue, the blood brain barrier, and other tissues. In some implementations, the systems described herein are used to test the impact of controlled factors on the tissue. The controlled factors can include flow rates, shear rates, and test chemicals (e.g., therapeutics and toxins). In some implementations, the system and methods are used to test pharmaceutical and biological therapies, characterize healthy or diseased tissue, and observe phenomena of the tissue in vitro.

The present invention provides a method and a device to image and characterize human tumors, and to classify the tumors as either malignant or benign. The method includes using a multi-compression technique upon the tissue or organ combined with a 3D ultrasound strain imaging of the compressed tissue or organ for acquiring raw data and analyzing the raw data using a computer processing unit equipped with a nonlinear biomechanical tissue model for tumor classification. A device is provided having a compression stage for delivering multi-compression with continuous force measurements, and a 3D ultrasound transducer strain imaging probe, wherein the imaging probe and the compression stage are in communication with a computer processing unit.

The invention relates to a method for establishing virtual reality assisted surgery based on medical images. The method comprises the following steps: acquiring volume data of specific tissues from amedical tomographic image of a patient, processing the volume data, and generating a three-dimensional human body tissue model represented by a tetrahedral network; according to the virtual reality glasses, a 3D model operating room is constructed, which is equivalent to the real operating room. The 3D human tissue model is added to the 3D model operating room, and a collision detection bounding box is added to the tissues in the tissue model to detect whether the tissues collide with each other in the simulated operation. The control device associated with the 3D model operating room is matched with the tissue model to obtain the matching relationship, so that the user can use the control device to perform virtual reality assisted surgery. The above method utilizes the tissue data extracted from the patient CT image data for three-dimensional modeling, and restores the real human tissue and surgical scene with the help of virtual reality equipment, so as to achieve the immersion and interaction caused by virtual surgery.

The invention provides a method and a device for preparing an in-vitro three-dimensional tissue model. The method comprises the following steps: (2) preparing a photocuring composite solution mixed with cells from an extracellular matrix material containing cells and growth factors, photocuring hydrogel and a photoinitiator; (3) adding the prepared photocuring composite solution to a forming tray, generating a changing controllable electric field by a control electrode array, and manipulating the cells by the aid of dielectrophoretic force to enable the cells to move and reach a target area; (4) importing a layer of tissue pattern data into a DMD (digital micromirror device), generating a photomask of the layer of tissue pattern, and curing the photocuring composite solution with a surface exposure technology; (5) after photocuring of the layer of the tissue is finished, repeating steps (3) and (4) for cell manipulation and photocuring for the next layer of tissue, and performing accumulation layer by layer to obtain the in-vitro three-dimensional bionic tissue model. Problems that the cells are difficult to manipulate, printing speed is low and the like in the prior art can be solved.

The invention relates to a preparation method of a tissue model with a cavity structure and the issue model. The method comprises the following steps: as for a target tissue with a cavity structure, acquiring a first three-dimensional geometric model having the same contour shape and size with a tissue; shrinking the first three-dimensional geometric model in the radial direction according to the wall thickness of the tissue, so as to obtain a second three-dimensional geometric model; manufacturing a bracket according to the second three-dimensional geometric model; coating a material used for manufacturing the tissue model on the surface of the bracket according to the wall thickness of the tissue; removing the bracket after the material is solidified, and obtaining the tissue model with the cavity structure. The high-precision tissue model, of which the size is close to that of the real tissue, is obtained for the tissue with the cavity structure through size design; as the tissue model is obtained through coating, the material of the tissue model is not limited by a consumable item of a traditional 3D printer, and the purpose of preparing the tissue model by choosing any proper material is fulfilled.