The invention provides a health medicine wine for relieving rigidity of muscles and promoting blood circulation, which is composed of following active ingredient materials: lopseed, camphor, frankincense, myrrh, fructus psoraleae, safflower, uncaria, radix sileris, fructus liquidambaris, rhubarb, heracleum hemsleyanum michaux, pawpaw, radix aconiti, cattail pollen, sapanwood, red paeonia, cistanche salsa, achyranthes, blood resin, atractylodes, homalomena rhizome, tuckahoe, ephedra equisetina, asarum, radix cyathulae, clematis chinensis and white wine. The medicine wine can effectively improve stomach function and adjust the human body internal secretion, rectify the decompensation, regulate the viscera, adjust the ying and yang balance, promote the blood cycle, enrich yin and nourish kidney so as to improve the human body immunity function and delay consenescence; using the medicine wine can also rapidly cure the diseases such as periarthritis humeroscapularis, cervical spondylosis, lumbar intervertebral disc protrusion, sciatica, rheumatism, rheumatoid disease and caput femoris necrosis; the medicine wine can realize the purpose of curing various diseases with one medicine, and can reach the heath care effect at the same time.