317 results about "Hydrogel composite" patented technology

The invention discloses a bionic nanofiber-hydrogel composite biological scaffold as well as a preparation method and application thereof. The bionic nanofiber-hydrogel composite biological scaffold is a composite scaffold for simulating a gray-white matter partition structure of a spinal cord tissue, and comprises bionic nanofibers and a bionic hydrogel material, wherein the bionic nanofibers are arranged in an oriented manner and simulate a white matter ordered structure around the spinal cord, and the bionic hydrogel material is combined with the bionic nanofibers and simulates gray matter in the center of the spinal cord. According to the bionic nanofiber-hydrogel composite biological scaffold, the biological activity of loaded stem cells or adult cells can be improved, the problem that a large number of transplanted exogenous cells die due to unbalanced oxidative stress generated after tissue damage can be solved, and it is guaranteed that the transplanted cells reside in a damaged area and play a role; therefore, the spinal cord microenvironment is improved, proliferation and differentiation of endogenous neural stem cells are promoted, functional recovery after spinal cord injury is finally promoted, and great potential is achieved in spinal cord injury treatment.

The invention discloses a plant leaf imitating hydrogel composite material and a preparation method thereof, and belongs to the field of bionic composite materials. The preparation method comprises the following steps: firstly, preparing printing paste by compounding a coloring agent, printing a fabric to obtain a green fabric capable of simulating spectral characteristics of green peaks and red edges of plant leaves, and simulating fence tissues and skeletons in a leaf structure by using the green fabric; then taking a biological material polyvinyl alcohol (PVA) as a base material, adding a monomer with strong hygroscopicity, a cross-linking agent and an initiator, and blending to prepare a hydrogel prepolymer solution; and finally, pouring the hydrogel prepolymer solution into a mold containing the green fabric for copolymerizing, so that hydrogel is directly formed on the surface of the fabric and in pores, and the plant leaf imitating hydrogel composite material is obtained. The material gets rid of dependence on moisture absorption salt, and has the advantages of stable water absorption and simulation effects, good durability and the like.

The invention provides a pH response hydrogel composite lithium adsorbent as well as a preparation method and application thereof. The method aims at solving the problems that an existing powder lithium adsorbent is poor in fluidity and difficult to recycle and reuse in practical application. The pH response hydrogel composite lithium adsorbent can expand under the alkaline adsorption condition required by a lithium ion sieve and shrink under the required acidic desorption environment, and the defect that the adsorption performance is reduced due to the fact that part of adsorption sites are covered when a traditional organic binder is formed is overcome. The preparation method of the pH response hydrogel composite lithium adsorbent comprises the following steps: dissolving acrylamide and acrylic acid in water, uniformly stirring, then adding a cross-linking agent and an initiator, dissolving and uniformly stirring, then adding lithium adsorbent powder, and ultrasonically dispersing uniformly to obtain a precursor solution; and adding a tetramethylethylenediamine accelerant into the precursor solution, quickly and uniformly stirring, sealing, standing and curing, washing with deionized water for multiple times, and drying to obtain the pH response hydrogel composite lithium adsorbent. The obtained adsorbent has the advantages of high mechanical strength, simple separation and recovery operation, good pH response cycle reversibility and the like. The hydrophilic three-dimensional network structure expands in an alkaline lithium-containing solution, so that lithium adsorbent particles are fully exposed, and the inherent high adsorption capacity of the powder lithium ion sieve is exerted.

The invention discloses a pH-responsive super-long dual-network hydrogel composite microneedle and a preparation method thereof, and belongs to the technical field of hydrogel microneedles, methacrylated gelatin and an oxidized hyaluronic acid solution are placed in an EP tube, a photoinitiator is added, the mixture is placed in a 37 DEG C water bath or a thermostat until the photoinitiator is completely dissolved, and a hydrogel microneedle filling solution is obtained; injecting the hydrogel microneedle filling solution into a PDMS microneedle mold, carrying out vacuum negative pressure, drying, and irradiating with a blue light lamp to obtain a dual-network hydrogel microneedle; the pH-responsive dual-network cross-linked hydrogel microneedle has the characteristics of adjustable length in a range of 200-3000 [mu] m, adjustable mechanical properties and various shapes, not only can controllably degrade and release loaded drugs in a pathological environment with unbalanced pH, but also has the advantages of large microneedle length, simplicity in manufacturing, low cost, controllable biocompatibility and the like, and can be applied to the field of medical treatment. The method has a good application prospect in the field of biomedicine.

The invention relates to a functional liquid metal-based temperature-responsive hydrogel material and a preparation method thereof, and belongs to the technical field of functional polymer hydrogel materials.The preparation method comprises the following steps that a temperature-responsive hydrogel composite material comprises a hydrophobic association polymer gel and a hydrogel monomer, the hydrophobic association polymer gel comprises a hydrophobic association polymer monomer, a functional filler and an initiator. The functional filler is liquid metal gallium with the edge modified by graphene oxide, and has triple functions: firstly, the functional filler is used as an electrostatic crosslinking node to form a crosslinking network with anionic ionic liquid; secondly, dynamic repair is promoted, and Ga < 3 + > is released to promote dynamic bond recombination. In addition, as a functional filler, the hydrogel is endowed with excellent photo-thermal and electro-thermal conversion performance, and the multi-stimulus response capability is enhanced. The composite material realizes structural assembly by means of hydrophobic association, shows reversible phase change and repeated self-assembly characteristics under various stimuli such as photo-thermal, electric heating, direct heating and the like, and has wide application potential.

The invention discloses a super-smooth, anti-corrosion and anti-coagulation hydrogel composite coating on the surface of a medical instrument as well as a preparation method and application of the super-smooth, anti-corrosion and anti-coagulation hydrogel composite coating, and the super-smooth, anti-corrosion and anti-coagulation hydrogel composite coating is a surface hydrogel composite coating formed by taking N-(3, 4-dihydroxyphenethyl)-2-benzoylbenzamide (BPDA) as a primer and grafting a hydrophilic polymer on the primer. BPDA is deposited on the surface of the substrate, then hydrophilic monomer surface graft polymerization is initiated by light, and a hydrogel coating is constructed on the surface of the BPDA substrate. The BPDA primer provides excellent corrosion resistance, the corrosion rate of a metal substrate is effectively reduced, and benzophenone derivatives with photoreaction activity on BPDA molecules can mediate firm combination of the hydrogel layer; after meeting water, a stable and compact hydrated layer is formed, the super-lubricating property is achieved, adhesion of protein and cells can be remarkably inhibited, and thrombus formation is effectively prevented. The anti-corrosion and anti-blood coagulation coating has excellent anti-corrosion and anti-blood coagulation properties, and is widely applicable to anti-blood coagulation and anti-corrosion surface modification in the fields of medical instruments and the like.

The invention discloses a magnesium alloy hydrogel composite scaffold, which comprises a magnesium alloy scaffold having a porous structure; the surface of the hydrogel cartilage layer is in contact with the magnesium alloy stent, and the hydrogel cartilage layer comprises methacrylated gelatin hydrogel, methacrylated hyaluronic acid hydrogel and methacrylated chitosan hydrogel. The formula of the cartilage layer simulates the components of normal transparent cartilage; and the Young modulus of the hydrogel is further improved by virtue of a unique soft and hard combined structure, and is improved by about 3 times so as to meet the mechanical strength of normal physiological cartilage. The fatigue resistance of the hydrogel is also improved due to the particularity of hardness and softness combination. And the magnesium alloy is combined with the hydrogel, so that electrochemical combination is further formed, and the magnesium alloy and the hydrogel are combined more tightly.

The invention discloses a liquid metal-hydrogel composite radiation protection material and a preparation method and application thereof.The preparation method comprises the steps that indium, tin and bismuth are sequentially put into a flask from low melting point to high melting point to be mixed, and glycerin is added for immersion; placing the mixture in an argon atmosphere, and stirring by using a heating type magnetic stirrer; taking out the spherical liquid metal particles from the glycerol, and finally washing and drying to obtain liquid metal alloy particles; preparing a PVA (polyvinyl alcohol)-H2O solution with the mass fraction of 15% and a PVA-DMSO (dimethyl sulfoxide) solution with the mass fraction of 15%; and a PVA-H2O solution, a PVA-DMSO solution and the liquid metal alloy particles are stirred and mixed according to the mass ratio, the mixed solution is subjected to ultrasonic treatment and then poured into a mold to be frozen into gel, and the liquid metal-hydrogel composite material is obtained. By combining the advantages of the liquid metal and the hydrogel, excellent biocompatibility, adjustable mechanical property and efficient radiation shielding capability are realized, and the hydrogel can be used as a novel lead-free radiation protection material.

The application discloses a kind of imitated plant leaf hydrogel composite material and preparation method thereof, belong to bionic composite material field.The application first by colorant compounding preparation printing paste, and fabric is printed, obtain the green fabric that can realize to plant leaf " green peak " and " red edge " spectral characteristic simulation, and with green fabric simulation leaf structure in fence organization and skeleton;Then with biomaterial polyvinyl alcohol (PVA) as base material, join with strong hygroscopic monomer and crosslinking agent, initiator blend preparation hydrogel prepolymer solution;Finally, hydrogel prepolymer solution is poured into the mold containing green fabric and copolymerization, it directly forms hydrogel in fabric surface and pore interior, obtains imitated plant leaf hydrogel composite material.The material gets rid of the dependence on hygroscopic salt, has water absorption and simulation effect stable, durability is good and the like advantages.

The invention belongs to the technical field of composite gradient materials, and particularly relates to a ceramic-hydrogel composite bone scaffold and a preparation method and application thereof, and the preparation method comprises the following steps: (1) mixing temperature-sensitive hydrogel with a phosphate buffer aqueous solution to form a temperature-sensitive hydrogel solution; (2) immersing a ceramic bracket into the temperature-sensitive hydrogel solution in the step (1), and carrying out ultrasonic treatment and cross-linking reaction to obtain a temperature-sensitive hydrogel permeated ceramic bracket; (3) mixing and swelling the photosensitive hydrogel and deionized water to form a photosensitive hydrogel solution; and (4) immersing the ceramic scaffold infiltrated by the temperature-sensitive hydrogel in the step (2) into the photosensitive hydrogel solution in the step (3), stirring, and performing ultraviolet radiation to obtain the ceramic-hydrogel composite bone scaffold. The two hydrogel solutions are respectively permeated into the ceramic bone scaffold, the defects of a pure ceramic scaffold in the aspects of osteogenesis performance and bone induction activity are overcome, and stem cells can be collected to grow into the bone scaffold.

The invention provides a nano-drug hydrogel composite system for bladder perfusion and application thereof, and provides a new concept for bladder perfusion drugs, i.e., hydrogel is used as a drug loading platform, and a concentration gradient is formed through permeation of urea; therefore, the nano-particles modified with the'motor 'in the hydrogel generate directional movement due to different pushing forces on the two sides. And the disorderly moving nano-particles are limited by external conditions, so that the aim of orderly and directionally moving the nano-particles is fulfilled. In the aspect of treatment, the effective concentration of the perfusion medicine is improved, deep penetration is carried out on the bladder tissue, a feasible scheme is provided for medicine delivery of deep tumor tissue, technical support and a new thought are provided for bladder perfusion treatment, and good application prospects are achieved.

The invention discloses a GelMA hydrogel composite material as well as a preparation method and application thereof, and belongs to the technical field of material preparation. A micro-needle-shaped GelMA hydrogel composite material (GelMA MNs) is prepared by grafting an anhydride functional group of methacrylic anhydride to a side chain amino group of gelatin, then doxorubicin and an aPD-L1 inhibitor are loaded into the GelMA MNs, a double-drug delivery system is established, and the prepared aPD-L1 / DoxatGelMA MNs can reduce skin injury to the maximum extent, and meanwhile, the aPD-L1 / DoxatGelMA MNs have a good application prospect. Recognition and killing of immune cells on melanoma cells are greatly started, immunogenic cell death (ICD) is promoted, and a new thought is provided for overcoming limitation of ICIs.

The invention provides a medical implant, a preparation method thereof and an artificial knee joint. The medical implant comprises a macromolecular porous stent and a hydrogel composite material at least filled in pores of the macromolecular porous stent, and the material of the macromolecular porous stent comprises a degradable macromolecular material and carbon nanotubes distributed in the degradable macromolecular material. The hydrogel composite material comprises a hydrogel material matrix and seed cells distributed in the hydrogel material matrix. According to the invention, the degradable high polymer material and the hydrogel material are combined, the carbon nanotubes are introduced into the degradable high polymer material, and meanwhile, seed cells are arranged in a hydrogel material matrix, so that the implantable stent material which has proper degradation performance and good mechanical properties and is renewable is provided.

A reinforced hydrogel composite including a porous synthetic or naturally derived retracted membrane material having a void volume, and a hydrogel at least partially filling the void volume; wherein the composite has a low strain (<50%) modulus from about 0.01 to about 10 MPa and a toughness from about 104 to about 107 J·m3. Methods for making the reinforced hydrogel composite and articles containing the reinforced hydrogel composite are also provided.

The invention provides a preparation method and application of a polyacrylamide / carboxylated chitosan / ionic liquid (PAM / CCS / ionic liquid) hydrogel composite material, and belongs to the technical field of hydrogel materials. Dispersion liquid of ionic liquid, carboxylated chitosan, acrylamide and zinc salt is subjected to polymerization reaction under the condition that an initiator and a cross-linking agent are added, and then the PAM / CCS / ionic liquid hydrogel composite material is prepared in situ. The preparation method provided by the invention is simple and efficient, and the obtained PAM / CCS / ionic liquid hydrogel composite material has high ionic conductivity, excellent mechanical properties and wider applicable temperature range. When the PAM / CCS / ionic liquid hydrogel composite material prepared by the method provided by the invention is used as a gel electrolyte of a zinc storage device, excellent electrochemical performance is shown.

The invention discloses concrete and a production method thereof. The concrete is prepared from the following raw materials in parts by weight: 100 to 120 parts of cement, 130 to 145 parts of coarse aggregate, 120 to 135 parts of fine aggregate, 10 to 25 parts of fly ash, 20 to 35 parts of slag powder, 25 to 38 parts of hydrogel composite fiber, 8 to 15 parts of borax, 6 to 11 parts of calcium stearate, 2 to 3 parts of polycarboxylate superplasticizer, 30 to 40 parts of modified emulsified asphalt and 50 to 65 parts of water. Wherein the hydrogel composite fiber is prepared from expanded perlite micro powder, polyurethane, polyacrylic acid and a hydrogel polymer through spinning. The concrete provided by the invention has good permeability resistance, compressive strength and toughness, and also has good freeze thawing resistance; the production method is simple, easy to operate and convenient to construct.

The invention belongs to the technical field of biological medicines, and particularly relates to nasal temperature-sensitive hydrogel with immunoregulation and anti-inflammatory functions as well as a preparation method and application of the nasal temperature-sensitive hydrogel. The preparation method of the nasal temperature-sensitive hydrogel with the immunoregulation and anti-inflammatory functions comprises the following steps: preparation of hydroxybutyl chitosan (HBC), preparation of levodopa-hydroxybutyl chitosan (LHBC), and preparation of CELHBC composite hydrogel. The novel temperature-sensitive hydrogel composite material of the composite hydrogel loaded with the chlorella / exosome can be used for the focus position of allergic rhinitis, and enrichment and retention of active ingredients are achieved; the chlorella is combined with the exosome, so that the inflammatory response of nasal mucosa can be relieved, the damaged nasal mucosa can be repaired, and the immune imbalance of Th1 / Th2 cells can be reversed, thereby improving the treatment effect of allergic rhinitis.

The application provides a thermoelectric hydrogel composite dressing for promoting repair of diabetic ulcers and loading of targeted modified exosomes and a preparation method, which comprises the following steps: preparing methacrylated hyaluronic acid; preparing polyether F127 diacrylate; co-incubating exosomes with palmitic acid grafted targeting peptides to prepare targeted modified exosomes; mixing the methacrylated hyaluronic acid, the polyether F127 diacrylate, a photosensitizer, the targeted modified exosomes and an electrolyte, and crosslinking under ultraviolet light to form a composite gel. The composite dressing is a novel composite dressing for thermoelectric stimulation and exosome treatment. On one hand, the dressing generates a wireless and passive electric field to simulate the endogenous electric field in the wound, promote directional migration of skin cells, accelerate reepithelialization and dermal formation; on the other hand, the dressing releases exosomes to precisely target blood vessels of a wound lesion, reverse endothelial dysfunction in a high-sugar environment and promote angiogenesis, and effectively solves the problems in repair and regeneration of diabetic ulcer wounds.

The invention discloses a photo-thermal hydrogel sponge with excellent salt resistance and a preparation method and application thereof, and belongs to the technical field of solar evaporators. The preparation method comprises the following steps: firstly, preparing melamine sponge (MS) with an asymmetric structure, filling a prepared polyacrylamide / graphene oxide (PAM / GO) hydrogel precursor solution and a prepared polyacrylamide / polyquaternium-7 (PAM / PQ7) hydrogel precursor solution into the melamine sponge by adopting a method of combining entering and injection, and preparing the polyacrylamide / polyquaternium-7 / PAM / PQ7 hydrogel composite material. The Janus structure photo-thermal hydrogel sponge with excellent salt resistance is obtained. The evaporator adopting the photo-thermal hydrogel sponge has an automatic salt resistance characteristic and an efficient salt resistance performance.

The invention discloses piezoelectric electrospinning rod compounded collagen-based hydrogel as well as a preparation method and application thereof, and belongs to the field of piezoelectric biological materials. Carrying out electrospinning on polyhydroxybutyrate through an electrospinning technology to prepare piezoelectric oriented fibers loaded with piezoelectric ceramics; preparing the piezoelectric oriented fiber into a piezoelectric electrospinning rod by using a freezing slicing technology; collagen and chitosan are cross-linked by using a biological cross-linking agent to form collagen-based hydrogel; and compounding the piezoelectric electrospinning rod in the collagen-based hydrogel to prepare the collagen-based hydrogel compounded by the piezoelectric electrospinning rod. The hydrogel prepared by the invention has good piezoelectric property, better mechanical property and excellent biocompatibility, and can well meet the requirement of an endogenous electric field at a cartilage defect.

The invention pertains to the field of pollution control, in particular it refers to contaminant removal and immobilization with hydrogel composite beads by carbonate precipitation of metals, metalloids, and radionuclides.

The invention relates to the technical field of composite material preparation, in particular to a preparation method of a polymer film / hydrogel composite material with a wrinkled surface. The preparation method of the polymer film / hydrogel composite material with the wrinkled surface comprises the steps that hydrogel comprises a first surface and a second surface which are oppositely arranged, the first surface adheres to a substrate, the second surface is coated with a polymer solution, and the polymer film / hydrogel composite material is obtained through light curing treatment and drying treatment in sequence; and soaking the polymer film / hydrogel composite material in water to obtain the polymer film / hydrogel composite material. By controlling the raw materials, the hydrogel thickness, the soaking treatment time and the like, the fold wavelength and amplitude of the polymer film / hydrogel composite material can be accurately regulated and controlled, and the requirements of different application scenes can be met.

The invention belongs to the field of medical dressing materials, and particularly relates to a metal organic framework / hydrogel composite material and a method and application thereof. The hydrogel composite material contains hydrogel and a metal organic framework, and the hydrogel composite material has a hybrid structure formed by mutual intersection of the hydrogel and the metal organic framework. The preparation method of the hydrogel composite material comprises the following step: carrying out coordination reaction on a solution containing metal ions, small molecular ligands and hydrogel to obtain the hydrogel composite material. The hydrogel composite material has the flexibility of the hydrogel and the mechanical strength and long-acting antibacterial property of the metal organic framework, the hydrogel and the MOFs are compounded to organically combine a flexible material and a rigid material, the performance of the hydrogel and the performance of the MOFs are improved, and the application value of the hydrogel composite material in the medical field is expanded. In practical application, the hydrogel has the advantages of promoting wound healing, resisting bacteria and having biocompatibility.

The invention belongs to the technical field of biomedical materials, and provides a piezoelectric anti-inflammatory fibrous membrane / hydrogel composite dressing and a preparation method thereof, and the preparation method comprises the following steps: purifying bacterial cellulose to remove residual strains and other components; carrying out hydroxylation surface treatment on barium titanate; uniformly mixing the purified bacterial cellulose hydroxylated barium titanate, and performing vacuum filtration to obtain a bacterial cellulose / hydroxylated barium titanate composite fiber membrane; the preparation method comprises the following steps: preparing a polydopamine solution, then adding epigallocatechin-3-gallate, acrylamide, N, N-methylene bisacrylamide and tetramethylethylenediamine, and fully stirring to obtain a hydrogel precursor; and finally, putting the obtained composite fiber membrane into a mold, and pouring the hydrogel precursor to obtain the composite fiber membrane / hydrogel composite dressing. The prepared dressing can promote wound healing through self power supply, ultrasound and application of mechanical stimulation, can also provide a moist environment, reduce inflammatory response of wounds and provide excellent oxidation resistance, and thus the wound healing effect of the dressing is improved.

The invention belongs to the technical field of conductive hydrogel composite materials, and relates to nanofiber reinforced composite organic hydrogel as well as a preparation method and application thereof.The method comprises the following preparation steps: synthesizing a thermoplastic polyurethane (TPU) nanofiber membrane in advance, uniformly filling a TPU stretchable matrix with carbon nanotubes (CNTs) in a solvent by adopting ultrasonic assistance, and preparing the nanofiber reinforced composite organic hydrogel. A conductive network is adjusted by adjusting the loading capacity of carbon nanotubes on a fiber membrane through different ultrasonic time, and the upper layer and the lower layer of the modified fiber membrane are coated with a polyvinyl alcohol / glycerol / aqueous solution to prepare a conductive CNTs (at) TPU-X nanofiber membrane (x is ultrasonic time), so that the elastomer film sensor with a sandwich-like structure is obtained. According to the invention, the problems of dispersibility of the nanofiller in a hydrogel matrix and interfacial compatibility of fibers and gel are solved.

The invention provides a natural Chinese herbal medicine hydrogel composite microneedle and a preparation method and application thereof.The preparation method comprises the steps that S1, natural food-borne nutrients and glycyrrhizic acid are mixed in a solvent, and a glycyrrhizic acid / natural food-borne nutrient solution is obtained; the natural food-borne nutrient is one or more of astaxanthin, baicalein, berberine and curcumin; s2, dropwise adding a metal salt solution into the glycyrrhizic acid / natural food-borne nutrient solution, and performing ultrasonic treatment and stirring to obtain glycyrrhizic acid / food-borne active substance gel; s3, mixing the polyanionic polymer solution with the glycyrrhizic acid / food-borne active substance gel to obtain a mixed solution; and S4, adding the mixed solution into a microneedle mold, carrying out vacuum centrifugation, and drying to obtain the microneedle patch. Good biocompatibility of the natural Chinese herbal medicine extract glycyrrhizic acid is used as a carrier to increase the in-vivo utilization rate of natural food-borne nutrients, so that a better treatment effect is achieved.

The invention discloses a magnetic metal organic framework hydrogel composite material as well as a preparation method and application thereof, and belongs to the technical field of detection. The magnetic metal organic framework hydrogel composite material is obtained by compounding magnetic metal organic framework particles and hydrogel; the magnetic metal organic framework particles are particles formed by coating Fe3O4 with MOF-545 (metal organic framework); the hydrogel is a cross-linked polymerization network formed by polymerization of polyacrylamide and sodium alginate; the magnetic metal organic framework is dispersed in the cross-linked polymerization network. The composite material has good adsorption capacity on malachite green dye, has good stability, portability and repeatability, and still has a relatively good adsorption effect on the malachite green dye under the condition that the composite material is repeatedly used for 6 times. The composite material can be used as a very promising material for separating and determining malachite green pollutants from aquatic products, and the rapid adsorption and enrichment effect of the composite material on malachite green greatly shortens the detection time.

The present invention relates to the field of medical repair materials and particularly to a double-crosslinked hydrogel composite material, a preparation method therefor, and use thereof. The double-crosslinked hydrogel composite material comprises a physical-chemical double-crosslinked copolymer formed by reacting at least one type of acrylic monomer and at least one type of zwitterionic monomer in the presence of nanoparticles and a crosslinking agent. The double-crosslinked hydrogel composite material of the present invention has the characteristics of high mechanical strength, high adhesion strength, and swelling resistance, is low in cost, and features a preparation process that is simple and rapid and easy to regulate. Therefore, the material has very high application value.

The invention discloses a hydrogel composite material for repairing acute kidney injury as well as preparation and application thereof. The hydrogel composite material for repairing the acute kidney injury comprises peroxisome serving as an oxidative stress regulation center and self-assembly repairing polypeptide gel for encapsulating the peroxisome. According to the composite material, oxidative stress regulation is carried out through a peroxisome cascade catalytic system, a polypeptide precursor solution is initiated to be self-assembled and polymerized into gel through pH responsiveness, local drug delivery is carried out, and cell repair regulation and control of kidney injury are achieved. The problem that oxidative stress and tissue damage are difficult to solve at the same time in existing single drug treatment is solved, wound healing is accelerated by rapidly neutralizing free radicals, reducing tissue damage, activating cell proliferation and regenerating related signal channels, the composition can act on damaged tissue more accurately, the influence on healthy cells is reduced, and due to the synergistic effect mechanism, the composition has a good application prospect. More efficient and targeted kidney repair can be realized, so that remarkable advantages are shown in the repair treatment of the acute kidney injury.

The invention provides a flexible stab-resistant composite material based on a three-dimensional angle interlocking fabric and a preparation method thereof, and relates to the technical field of composite materials, and the preparation method comprises the following steps: weaving the three-dimensional angle interlocking fabric with an interlayer oblique crossing angle interlocking structure; polyvinyl alcohol-sodium alginate hydrogel is prepared; the three-dimensional angle interlocking fabric is coated with the polyvinyl alcohol-sodium alginate hydrogel; and freezing and unfreezing the three-dimensional angle interlocking fabric coated with the polyvinyl alcohol-sodium alginate hydrogel to obtain the three-dimensional angle interlocking fabric-hydrogel composite material. The high-performance fiber three-dimensional angle interlocking fabric is used as a reinforcing body, the tough hydrogel is used as a flexible matrix, the protective performance of the stab-resistant material in a low-temperature environment is guaranteed, meanwhile, the stab-resistant material is endowed with multiple functions such as strain sensing and air and moisture permeability, and the balance of the protective effect, wearing comfort and multiple functions is achieved.