24 results about "Hydrogel composite" patented technology

This invention relates to a dual-mode polycaprolactone (PCL) building energy-saving film and its preparation method. The dual-mode PCL building energy-saving film of this invention uses a temperature-sensitive PCL and hydrogel composite layer as the outer layer, and adds VO2-based materials. It can automatically reflect near-infrared light during high summer temperatures and automatically project sunlight during low winter temperatures; it requires no external power supply and is purely passively regulated. Furthermore, a PCL-based triboelectric nanogenerator array serves as the middle layer, which can collect mechanical energy from the building surface environment to power low-power sensors within the building, and can also connect surplus energy to the grid or store it. The transparent PCL and nanocellulose composite layer provides better mechanical support and is easy to install.

The present application relates to the technical field of biotechnology and cosmetic material technology, and particularly discloses a polypeptide composition-hydrogel composite delivery system for regulating skin sebum membrane stability, and a preparation method and application thereof. The composite delivery system comprises a polypeptide composition, a hydrogel matrix, a penetration enhancer and deionized water; and the polypeptide composition is composed of an antibacterial polypeptide, a prebiotic polypeptide and an immunomodulatory polypeptide. The preparation method comprises the following steps: dissolving the antibacterial polypeptide, the prebiotic polypeptide and the immunomodulatory polypeptide in a phosphate buffer to obtain a polypeptide composition solution; dispersing the hydrogel matrix in deionized water, mixing the penetration enhancer after stirring and swelling, adding the polypeptide composition solution dropwise, adjusting the pH value, vacuum degassing, and then freeze-drying to obtain the composite delivery system. The preparation method is simple, the obtained composite system is weakly acidic, highly matches the physiological pH value of a healthy sebum membrane, helps to maintain a weakly acidic environment on the surface of the skin for a long time, and further inhibits the reproduction of harmful bacteria from a physical environment.

This invention discloses a room-temperature self-healing electromagnetic shielding hydrogel composite material and its preparation method, belonging to the field of composite material technology. The composite material uses polyvinyl alcohol containing aryl indole groups and conductive materials as raw materials, and ferric chloride and borax as crosslinking agents. Based on the steric hindrance effect introduced by the large-volume groups and the multiple dynamic bonds constructed in the system, this invention enables the composite material to exhibit highly efficient self-healing ability, high mechanical strength, and excellent electromagnetic interference shielding performance at room temperature. Through repeated wetting and drying treatments, the electromagnetic shielding efficiency of the hydrogel can be reversibly switched between on / off states, making it suitable for applications in flexible electronics and intelligent shielding, thus solving the problem that traditional hydrogel materials struggle to simultaneously achieve self-healing performance, mechanical strength, and electromagnetic shielding effectiveness.

The application discloses a kind of leaf-like hydrogel composite fabric and preparation method thereof, belong to bionic composite material field.The preparation of leaf-like hydrogel composite fabric of the application includes as follows: respectively preparing uniform sodium alginate solution and acidic solution, after injecting sodium alginate solution into mould, green fabric is laid on its surface and is stationary for a certain time, then acidic solution is added again, stationary is acid-induced phase separation, i.e., hydrogel composite fabric with directional conical porous structure is obtained;After that, it is immersed in hygroscopic salt solution, after standing, leaf-like hydrogel composite fabric is prepared.The bionic composite fabric presents complete plant leaf spectral characteristics in the range of 400~2500 nm, and can efficiently simulate the transpiration of plant leaf.In addition, the material has good hygroscopic-desorption cycle stability, which guarantees the reliability of the bionic material in long-term application in the field of camouflage.

The application provides a method for continuously producing chitooligosaccharide with specific polymerization degree by using an immobilized enzyme membrane reactor. The method is as follows: 1. preparing a PLGA nanofiber-temperature-sensitive hydrogel composite carrier, fixing the carrier in the inner wall of a ceramic membrane to obtain a composite carrier membrane; 2. assembling the composite carrier membrane into a folding enzyme membrane reactor with temperature control, pressure monitoring and material switching units; 3. introducing enzyme solution to fix chitosanase, and then introducing pretreated chitosan substrate to catalyze the reaction; 4. monitoring the polymerization degree on line to control the reaction process, washing the reactor after the reaction to realize continuous production, and concentrating and spray drying the product to obtain the target product. The application fuses the characteristics of multiple carriers to construct a “rigid support-flexible regulation” structure: the ceramic provides stable mechanical support, the temperature-sensitive hydrogel adjusts the swelling degree with temperature, the enzyme active site is exposed at low temperature to improve the efficiency, and the product is released by shrinking at a later stage, so that the problem of product retention and side reaction is solved.

This invention discloses a method for preparing a hydrogel composite dressing for post-circumcision care, specifically implemented according to the following steps: Step 1, preparing an MXene nanosheet dispersion; Step 2, preparing a lidocaine-chitosan-gellan gel composite; Step 3, mixing the MXene dispersion from Step 1 with the lidocaine-chitosan-gellan gel composite from Step 2, and adding a menthol derivative to prepare a multifunctional hydrogel composite dressing. This invention also discloses the hydrogel composite dressing prepared by this method. This invention accelerates wound healing through the antibacterial, hemostatic, and epithelial cell regeneration-promoting effects of chitosan; through the photothermal conversion capability of MXene, local mild thermotherapy can be achieved under near-infrared light irradiation, promoting blood circulation and reducing edema, while MXene itself has good antibacterial properties.

This invention proposes a PVA-PVP hydrogel composite fatty acid flexible phase change film and its preparation method. Utilizing the polar groups such as the hydroxyl groups on the PVA molecular chain and the carbonyl groups on the PVP molecular chain, strong intermolecular hydrogen bonds are formed between the fatty acid molecules and the carboxyl groups at the ends of the fatty acid molecules, stably anchoring the fatty acid within the hydrogel network. Even after the fatty acid melts, its macroscopic flow is restricted by the network structure, thus achieving intrinsic morphological stability and leak-proof function. Simultaneously, PVP, as an amphiphilic polymer, effectively improves the interfacial compatibility between the hydrophobic fatty acid and the hydrophilic PVA / PVP gel network, avoiding phase separation during long-term use. Furthermore, a dense intermolecular hydrogen bond network is formed between PVA and PVP, with PVA acting as a rigid framework and PVP as a flexible modifier. Their synergistic effect ensures that the composite gel network maintains structural stability while possessing excellent bending and tensile properties.

The application discloses a low-melting-point alloy / temperature-sensitive hydrogel composite bone cement and a preparation method thereof. The temperature-sensitive hydrogel is wrapped outside the low-melting-point alloy, the liquid temperature-sensitive hydrogel can absorb the heat released by the low-melting-point alloy during solidification and is converted into a gel state, and the low-melting-point alloy is rapidly cooled after being wrapped by the temperature-sensitive hydrogel and is not in direct contact with the surrounding bone tissue, so that the low-melting-point alloy avoids causing thermal damage to the surrounding tissue, reduces the pain of patients, promotes the rapid healing of the affected area, and the composite bone cement also has the advantages of fast solidification speed, simple preparation process, stable structure in the in-vivo and in-vitro environments and the like.

The present application relates to the technical field of hydrogel composite scaffold, in particular to a layer-by-layer self-assembled oxygen-responsive liposome hydrogel composite scaffold and a preparation method, hydrophilic nerve growth factor (GDNF) is encapsulated in the aqueous internal region of the liposome, and low-oxygen-responsive vascular endothelial growth factor (VEGF) plasmid and polyarginine are coated by electrostatic adsorption layer by layer (LBL), so as to construct an intelligent responsive LBL double-drug cationic liposome; subsequently, hyaluronic acid-carboxymethyl cellulose sodium (HA-CMC) hydrogel is introduced to carry the liposome to form a double-drug composite scaffold, so as to enhance the adhesion and local release characteristics of the composite scaffold on the wound surface. In a diabetic animal model, the LBL liposome loaded on the HA / CMC hydrogel can significantly accelerate wound healing, promote collagen deposition, angiogenesis and nerve fiber regeneration, and regulate the polarization of macrophages to the repair phenotype, thereby reducing the inflammatory response and achieving functional tissue repair.

This invention discloses a nanoengineered bacteria-hydrogel composite formulation for local treatment of postoperative pancreatic ductal adenocarcinoma, its preparation method, and its application. The preparation method includes adding a tetrahydrofuran solution containing DSPE-PEG-NH2 to a mixture of THF-H2O and rotary evaporating to obtain NPs-N; mixing the obtained Bt bacterial suspension with a 2-iminothiacyclopentane solution to obtain Bt-SH; co-incubating Bt-SH and NPs-N to obtain NPs-N@Bt, and then adding it to a GelMA solution to form a gel. This nanoengineered bacteria-hydrogel composite formulation can spontaneously form a digestive enzyme protein crown in the postoperative microenvironment, promoting bacterial penetration and preventing pancreatic fistula. After the bacteria degrade deep-seated mucin, they release mucin from the tumor microenvironment, restoring the sensitivity of PDAC tumors to digestive enzymes and effectively controlling tumor recurrence and metastasis.

The application relates to the technical field of functional materials, and discloses a preparation method of a silver-based metal-organic framework hydrogel composite material and application of the silver-based metal-organic framework hydrogel composite material in antibiosis, which comprises the following steps: respectively dissolving silver nitrate and 3-methyl-5-trifluoromethyl-1H-1,2,4-triazole in 5 milliliters of 5% ammonia water according to a molar ratio of 1:1; synthesizing by adopting an interfacial synthesis method, with 5 milliliters of 5% ammonia water as an intermediate layer; avoiding light and standing; adding the silver-based metal-organic framework material into distilled water, and ultrasonic dispersing for a second preset time length; mixing with carbomer with a concentration of 9.8 grams per liter, adding triethanolamine with a concentration of 5 grams per liter when the solution becomes clear; and stirring at a second mixing rate until a uniform gel is formed. The silver-based metal-organic framework hydrogel composite material prepared by the application has excellent antibacterial activity, biocompatibility, appropriate mechanical properties and adhesion, stable rheological properties, and is stronger than a commercial AgNPs-gel.

The application discloses a temperature-controlled driving self-adaptive fruit picking front-end device and a grabbing method thereof, and the device comprises a splitable petal structure arc-shaped spherical claw and a driving device; the arc-shaped spherical claw comprises, from inside to outside, an arc-shaped spherical claw head inner shell, a food-grade rubber layer, a temperature-sensitive hydrogel composite layer and an arc-shaped spherical claw head outer shell; the driving device comprises an opening and closing driving unit and a rotating driving unit, the opening and closing driving unit is connected with the arc-shaped spherical claw head outer shell of the arc-shaped spherical claw and drives the arc-shaped spherical claw to open and close; and the rotating driving unit is connected with the opening and closing driving unit and drives the rotating driving unit and the arc-shaped spherical claw to rotate around the central axis. The application solves the problems that the end effector of a traditional agricultural picking robot cannot dynamically adapt to the poor shape adaptability and the imprecise grabbing force control when grabbing irregular-shaped and fragile-skinned fruits.

This invention discloses a ROS- and pH-responsive hydrogel complex loaded with exosomes, its preparation method, and its applications, belonging to the field of biomedical engineering. The hydrogel complex of this invention comprises a ROS- and pH-responsive hydrogel carrier and exosomes loaded within the carrier. The hydrogel carrier is a three-dimensional network structure formed by dynamic covalent bonding between phenylboronic acid-modified hyaluronic acid and dopamine-modified gelatin. This hydrogel complex enables controlled release of exosomes, addressing the problems of short in vivo half-life, poor targeting, uncontrollable release, and inability to effectively address secondary damage cascade reactions associated with exosomes.

The application discloses a self-healing hydrogel with electric conductivity and anti-freezing performance and a preparation method thereof, and belongs to the technical field of high polymer materials. The PEDOT:PSS-DMSO mixed solution is prepared, the mixed solution is mixed with SL to prepare a P:P-D@SL compound suspension, and the addition of DMSO partially releases the chain entanglement of PEDOT:PSS, so that the electric conductivity and solubility of PEDOT:PSS are improved. Meanwhile, PEDOT:PSS carries -SO3H, and is combined with SL through electrostatic interaction and ion exchange, so that the stability and electric conductivity of the compound suspension are enhanced. In addition, DMSO can also reduce the crystallization point of the hydrogel by destroying the hydrogen bond interaction between water molecules. The self-healing hydrogel composite hydrogel with electric conductivity and anti-freezing performance is prepared by adopting a one-pot method combined with F-T circulation, the prepared hydrogel can be applied to the fields of equipment detection, strain sensing, intelligent skin, human health monitoring and medical devices, can perceive external environmental changes and make corresponding responses, and basically meets the demand for high-performance materials at present.

This invention discloses a temperature-responsive hydrogel with a low critical solution temperature 37°C higher than physiological temperature. It is formed by the polymerization reaction of comonomers N-isopropylacrylamide, 1-pyrene methacrylate, and acrylic acid with a crosslinking agent initiated by a free radical initiator. This invention further provides an enzyme-carrying hydrogel prepared from the aforementioned temperature-responsive hydrogel and a carbon nanotube-enzyme-carrying hydrogel composite material. The carbon nanotube-enzyme-carrying hydrogel composite material of this invention is in a swollen state at physiological temperature, and its reversible swelling-contraction changes, regulated by near-infrared light, dynamically regulate the catalytic activity of biological enzymes. Furthermore, carbon nanotubes possess excellent conductivity, and changes in the microgel morphology promote electron transfer within the three-dimensional conductive framework of the composite material, thereby enhancing the electrochemical response. The carbon nanotube-enzyme-carrying hydrogel composite material of this invention can be used to construct intelligent sensors suitable for in vivo controlled analysis.

This invention discloses an MXene-modified polysiloxane-nitrogen heterocyclic hybrid hydrogel composite atmospheric water collection material and its preparation method. The water collection material is a three-dimensional porous structure of a hybrid hydrogel constructed from polysiloxane and nitrogen heterocycles. MXene is loaded into this three-dimensional porous structure, which is further impregnated with lithium chloride hygroscopic salt. This water collection material utilizes the flexible network of polysiloxane, the hydrophilic adsorption sites of nitrogen heterocycles, the photothermal conversion properties of MXene, and the high hygroscopicity of lithium chloride to achieve efficient adsorption over a wide humidity range and rapid desorption driven by sunlight. The preparation process of this invention is mild and has good cycle stability, effectively solving the problem of hygroscopic salt leakage, and can be widely applied to atmospheric water collection in arid and semi-arid regions.

The application discloses a kind of liquid metal flexible electronic devices with porous shaddock skin as framework and a preparation method thereof, with the porous sponge layer of natural shaddock skin as framework, by mixing liquid metal with solid particles to prepare conductive filler with plasticity, and with the aid of mask and magnetic field, the precise patterning of liquid metal circuit on the surface of shaddock skin is realized.Subsequently, the adhesive pre-gel containing adhesive enhancement component and glycerol / water mixed solvent is injected into the porous structure of shaddock skin, and the adhesive pre-gel is cured by photopolymerization, and finally the liquid metal / shaddock hydrogel composite electronic device is obtained.The electronic device prepared by the application has high conductivity of liquid metal, flexibility of shaddock framework and adhesion of hydrogel, and has excellent anti-freezing and anti-drying performance due to the introduction of glycerol, and can be stably applied in the fields of efficient thermal management and motion detection.The preparation process of the application is simple, low in cost and environmentally friendly, and provides a new idea for the development of flexible electronic devices.

The present application relates to the technical field of biomedical materials, and specifically discloses a hydrogel composite material, a preparation method and application thereof. The composite material is formed by organically combining the three-dimensional network support of methacrylated gelatin, the efficient drug delivery capacity and biological activity regulation function of plant-derived exosomes, and the efficient contact type antibacterial mechanism of N-chlorinated MOF, forming a multifunctional composite system with antibacterial, anti-inflammatory and healing functions. The application of the composite hydrogel in the preparation of medical dressings can solve the clinical problems of infection control difficulty, low wound repair efficiency and poor dressing adhesion in the treatment of chronic refractory wounds, significantly improve the wound care effect, and provide a new and efficient medical material for the clinical treatment of chronic refractory wounds.

An embodiment of the present invention provides a method for manufacturing a DNA / SWCNT nanosensor, the method comprising the steps of: forming a mixed solution in which a single-walled carbon nanotube (SWCNT) and a single-stranded DNA (ssDNA) sequence are mixed; sonicating the formed mixed solution to adsorb the single-stranded DNA (ssDNA) sequence onto the surface of the single-walled carbon nanotube (SWCNT); and removing impurities and aggregates through centrifugation.

The invention discloses a preparation method and application of a water vapor adsorption-desorption temperature-controlled COF-based hydrogel composite material, and the preparation method at least comprises the following steps: I, dissolving acrylamide in water, and stirring I to form a hydrogel precursor; iI, adding COF powder into the hydrogel precursor obtained in the step I, stirring II, adding a cross-linking agent, an initiator and an accelerant, and curing to obtain the COF-based hydrogel. Compared with an existing solid-liquid phase change temperature control material, the COF-based hydrogel composite material prepared through the method has a higher enthalpy value, has important application prospects in the field of heat management and can meet various temperature control application requirements such as house cooling, electronic equipment cooling, industrial cooling and food storage.

The application discloses a kind of porous framework base hydrogel composite membrane and its separation application.Based on the excellent water retention, self-repairing and biocompatibility of hydrogel, combined with the advantages of high specific surface area and porosity of porous framework material, the porous framework material functionalized hydrogel composite membrane is constructed by ion interaction crosslinking, ultraviolet crosslinking or thermal crosslinking, so as to show excellent molecular / ion separation performance.The preparation method includes solvothermal synthesis of metal organic framework / covalent organic framework / metal organic polyhedron / porous organic cage and other framework material powder, hydrogel monomer solution preparation, crosslinking film forming and other steps.The application dopes framework material in hydrogel network, and shows excellent gas separation, organic dehydration, dye separation and ion sieving performance under the dual action of humid environment and inherent pore size sieving of framework material, which has broad application prospect.

The application relates to the field of drug controlled release, and particularly discloses a sustained-release ropivacaine magnetic-temperature double-response intelligent hydrogel composite preparation and a preparation method. The sustained-release ropivacaine magnetic-temperature double-response intelligent hydrogel composite preparation comprises the following raw materials in parts by weight: 12-18 parts of temperature-sensitive triblock copolymer, 10-20 parts of a thermal response supramolecular prodrug complex, 10-20 parts of PLGA ropivacaine microspheres, 2-5 parts of double-ligand modified magnetic nanoparticles, 3-8 parts of a sustained-release ropivacaine preparation CPL-01 and 40-60 parts of sterile phosphate buffer. The temperature-sensitive triblock copolymer is used to provide a skeleton structure for in-situ gelation at body temperature, the PLGA ropivacaine microspheres and the sustained-release ropivacaine preparation CPL-01 are respectively used to provide long-acting maintenance and initial basic release, and the double-ligand modified magnetic nanoparticles generate a local thermal effect under an alternating magnetic field, so that concentrated burst release can be formed in a short time.

The present disclosure relates to a biodegradable polymer-gelatin hydrogel composite, a method for preparing the same and a medical implant including the biodegradable polymer-gelatin hydrogel composite. The multi-layered biodegradable polymer-gelatin hydrogel composite of the present disclosure, wherein the biodegradable polymer membrane of a 3D reticular structure and the gelatin hydrogel are stacked, has superior durability and resilience and may exhibit improved elasticity and swellability upon wetting under hydration environment. In addition, it can be shrunk down to 50% of its initial volume upon drying and can maintain elasticity even after the shrinkage. Furthermore, when used in a medical implant, it can protect the joint from the frictional environment in the body, reinforce the muscle torn or ruptured by trauma, relive pain by maintaining space, and induce the improvement of symptoms.