The invention discloses a threshold-adjustable quicksilver microfluid inertia switch based on electrowetting, and relates to switches. A top adjustment electrode and a bottom adjustment electrode are respectively deposited on a glass cover plate and a glass substrate, silicon dioxide layers are deposited on the top adjustment electrode and the bottom adjustment electrode, a microchannel is communicated with a liquid trough through butt joint, the tail end of the microchannel changes gradually and gathers to form a micro valve, the liquid trough is communicated with gas-guide tubes on the two sides of the liquid trough, quicksilver micro-droplets are arranged inside the microchannel, one end of a signal electrode penetrates into the liquid trough, and the signal electrode is fixedly arranged on the silicon dioxide layers. According to the threshold-adjustable quicksilver microfluid inertia switch based on electrowetting, an electrowetting method is adopted, the threshold of quicksilver microfluid inertia switch can be adjusted, a 'solid-liquid' contact form is adopted, the stability of the current characteristic is guaranteed, the effective contact area of a switch contact is enlarged, the on resistance is small, the interface circuit is simple, and the overload capacity of the switch is improved. The threshold-adjustable quicksilver microfluid inertia switch based on electrowetting is suitable for the field such as military weapon systems, civil mechatronics and consumer electronics.