The invention provides a vertical five axle interlocked gantry digital control milling machining center, comprising a planer body, a portal frame, a rotary workbench stand, an electrical appliance control cabinet, a cutter, a main spindle box, an operation panel, a rotary workbench, X, Y and Z shaft driving screws and rotary tool changers, wherein the rotary workbench is formed by a large rotary workbench and a small rotary workbench which respectively rotate around an A shaft and a B shaft; the portal frame is arranged on the planer boxy and can move back and forth via the X shaft driving screws arranged at the two sides of the planer body, a Y-Z shaft connection block moves left and right via the Y shaft driving screw in the portal frame, and a main spindle in the main spindle box moves up and down via the Z shaft driving screw on the Y-Z connection block so as to form five axle interlocking; and the rotary tool changers arranged at the two sides of the portal frame are internally provided with 32 grinding cutters and milling cutters, and tool changing is realized by a tool changing manipulator. The invention has the positive effects of realizing multiply functions of one machine, and can process as many as five interfaces by primary clamping, thus reducing clamping times, saving labor, time and space, and having convenient equipment maintenance.