4results about How to "Flexible application form" patented technology

This invention belongs to the field of functional substance research, specifically relating to the use of casein hydrolyzed peptide compositions in improving aging, and more specifically to their use in the preparation of products for improving aging. The casein hydrolyzed peptide compositions are obtained by enzymatically hydrolyzing casein solution using serine protease and flavor protease. Furthermore, in the casein hydrolyzed peptide compositions, the relative strength of total functional peptides is above 25%, the relative strength of casein phosphopeptides is above 9%, and the relative strength of functional peptides other than casein phosphopeptides is above 11%. This casein hydrolyzed peptide composition can effectively alleviate oxidative stress caused by aging, inhibit chronic low-grade inflammation, reduce aging-related damage to vital organs such as the liver and brain, improve the body's immune function, and improve the external phenotype of aging, thereby comprehensively exerting an anti-aging effect.

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

This invention discloses the use of phytic acid in the preparation of drugs or functional foods for regulating intestinal flora imbalance caused by Streptococcus mutans, belonging to the field of biomedicine and microecological regulation technology. This invention is the first to discover that oral phytic acid can effectively inhibit the abnormal colonization of Streptococcus mutans in the intestine, restore intestinal flora diversity, increase the abundance of beneficial bacteria (such as Bifidobacterium and Lactobacillus), reduce the proportion of pro-inflammatory bacteria, and improve intestinal barrier function and inflammatory status. This invention provides a new strategy for regulating intestinal flora imbalance caused by Streptococcus mutans.

The present application relates to the fields of microbial technology and tumor biological therapy, and particularly relates to a bacillus pumilus and application thereof, a protein preparation and a microbial preparation. The bacillus pumilus is named bacillus pumilus BP01, is isolated from the oral cavity of healthy people, and is preserved in China Center for Type Culture Collection on April 2, 2026, with a preservation number of CCTCC NO: M2026574. The 16S rRNA gene sequence of the bacillus pumilus is SEQ ID NO: 1. Compared with the prior art, the bacillus pumilus of the present application is derived from the normal oral cavity of people and has high safety. The culture product of the bacillus pumilus can significantly inhibit the proliferation and clonogenic ability of hepatocarcinoma, hepatoblastoma, colorectal cancer, bladder cancer and endometrial cancer cells. In an in vivo animal model, the bacillus pumilus shows stable anti-tumor effect and does not cause obvious toxic side effects. The bacillus pumilus can be used as a live bacterial preparation, and can also play an anti-tumor role through culture supernatant or metabolic products, and has flexible application forms. The bacillus pumilus has good clinical transformation and industrial application prospects.