The invention discloses a medicinal composition for treating pulmonary tuberculosis, and a preparation method and a use thereof. The medicinal composition is prepared from Radix Glehniae, Radix Stemonae, Anemone chinensis, Radix Ranunculi Ternati, Common Boxwood, Cortex Lycii, centipedes, Fagopyrum cymosum, Orange Sugarmustard, Metaplexis japonica (Thunb.) Makino, Human Placenta, Veronica peregrina L., Fritillaria cirrhosa, deerhorn glue, turtle shell, Hibiscus trionum, Poria cocos, Meconopsis punicea, oyster, tingli seed and pork lung extract; the pork lung extract is one or more of phosphatidylcholine, dipalmitoylphosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol and sphingomyelin; and the effective component of Common Boxwood is cycloprotobuxinamin. The medicinal composition adopting traditional Chinese medicine and western medicine combination has the efficacies of moistening lung and relieving coughs, clearing heat and eliminating inflammation, cooling blood and stopping bleeding, and eliminating swelling and relieving pains, and has the advantages of substantial pulmonary tuberculosis treatment effect, safety, reliability, no toxic or side effects, short treatment course, fast effectiveness, low cost, and reaching of the purpose of simultaneous treatment of principal and subordinate symptoms.