2 results about "Acacetin" patented technology

The application belongs to the technical field of medicine, and particularly relates to application of acacetin or 6-hydroxyflavone in preparation of anti-angina pectoris drugs, and aims to solve the problems of adverse reactions such as blood pressure drop, reflex tachycardia and the like caused by non-selective vasodilation of existing anti-angina pectoris drugs, wherein the drug improves myocardial blood supply by selectively dilating coronary vessels of the heart, wherein acacetin dilates coronary vessels of the heart by inhibiting cardiac coronary vessel myosin light chain kinase and activating myosin light chain phosphatase, and 6-hydroxyflavone dilates coronary vessels of the heart by inhibiting protein kinase C and enhancing myosin light chain phosphatase activity; and the acacetin or 6-hydroxyflavone significantly reduces the symptoms of myocardial ischemia of rats caused by isopropyl adrenaline, improves characteristic ECG abnormal changes of angina pectoris, does not affect heart rate and systemic blood pressure, and is safer, thereby providing a potential drug selection for anti-angina pectoris treatment.

The application discloses a propolis extract and a production process thereof. According to mass percentage, the propolis extract comprises 25-40% of total flavones, 15-30% of total phenolic acids, 10-20% of propolis anthracene acid compounds, ≤3% of moisture, ≤2% of ash, and the balance of other natural propolis components; and the sum of acacetin, galangin and pinocembrin in the total flavones accounts for 30-50% of the mass of the total flavones. The production process comprises freezing and crushing, complex enzymolysis, ultrasonic-assisted ethanol extraction, dewaxing, macroporous adsorption resin purification and drying. The application combines enzymolysis and ultrasonic to significantly improve the extraction rate and purity of active ingredients, and the obtained propolis extract has clear components, high active ingredient content, few impurities, and the process is green and efficient, and is suitable for industrial production.