Application of acacetin extracted from Huai flos chrysanthemums in preparation of estrogenic medicines

A technology of acacetin and estrogen, applied in the field of medicine

Inactive Publication Date: 2020-01-24
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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However, there is no public report on proposing acacetin from Hua...

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  • Application of acacetin extracted from Huai flos chrysanthemums in preparation of estrogenic medicines
  • Application of acacetin extracted from Huai flos chrysanthemums in preparation of estrogenic medicines
  • Application of acacetin extracted from Huai flos chrysanthemums in preparation of estrogenic medicines

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[0016] The specific implementation of the present invention will be described in detail below in conjunction with the examples.

[0017] A kind of acacetin extracted from Huai chrysanthemum of the present invention, the extraction method is, take by weighing 12kg of Huai chrysanthemum, use 12L volume concentration 50% acetone tissue to break and extract twice each time, combine filtrate, 45 ℃ low temperature, pressure 30hpa concentrate to obtain The total extract is 3.8kg; the total extract is dispersed and dissolved into an extract liquid with 4L of water, and petroleum ether, ethyl acetate, and n-butanol are used to extract the same volume of the extract liquid to obtain the petroleum ether part, ethyl acetate part, Part of n-butanol; take 360.0 g of the dried ethyl acetate part, dissolve it with ethyl acetate, mix well with silica gel, evaporate to dryness, and perform silica gel column chromatography. Proportions were mixed together as eluent for elution (Note: What is the...

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Abstract

The invention relates to application of acacetin extracted from Huai flos chrysanthemums in preparation of estrogenic medicines, which aims at extracting acacetin form Huai flos chrysanthemums and preparing the estrogenic medicines by using the extracted acacetin. The acacetin of the flos chrysanthemums is obtained by the steps of performing tissue breaking on Huai flos chrysanthemums with acetonetwice, performing extraction twice, combining filtrates, and performing lower-temperature decompressed concentration to obtain a total extract; dispersing and dissolving the total extract by water, performing extraction with petroleum ether, ethyl acetate and n-butyl alcohol, taking dried ethyl acetate portions, performing dissolving with ethyl acetate, uniformly blending silica gel, then performing evaporation to dryness, performing silica gel column chromatography, performing spin drying on an eluent, performing dissolving in water, adding Toyopearl HW-40, performing gradient eluting with water and aqueous methanol in different proportions sequentially, sequentially treating the eluted part with sephadexLH-20, ODS, Silica gel and MCL Gel CHP-20 columns, and performing separation and purification in combination with methods for preparing high-efficient liquid phases and recrystallization. For the first time, the invention finds that the acacetin of the Huai flos chrysanthemum has anestrogen effect in bodies and plays a role in an estrogen receptor way, and a new purpose of the acacetin is opened up.

Description

technical field [0001] The invention relates to medicine, in particular to the application of acacetin extracted from Huai chrysanthemum in the preparation of estrogen-like drugs. Background technique [0002] Phytoestrogens exist in some natural plants and have estrogen-like effects. Phytoestrogens can bind to estrogen receptors and estrogen-related receptors in the body to regulate estrogen receptors bidirectionally, showing estrogen-like activity. Compared with synthetic estrogen, natural phytoestrogens have lower estrogen-like activity, but cause fewer side effects such as breast cancer and endometrial cancer, and have high safety. Therefore, the research on phytoestrogens has gradually become a hot spot. [0003] Huai chrysanthemum has high medicinal value, belongs to medicinal chrysanthemum, tastes sweet and bitter, cool in nature, contains about 0.13% volatile oil, inulin, adenine, choline, stachydrine, trace vitamin A-like substances, vitamin B, amino acids and lo...

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Application Information

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IPC IPC(8): A61K31/352A61P5/30C07D311/30
CPCA61K31/352A61P5/30C07D311/30
Inventor 郑晓珂傅阳克迎迎袁培培张奇侯颖高丽媛魏亚新陈文静冯卫生
Owner HENAN UNIV OF CHINESE MEDICINE
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