73results about How to "Develop medicinal value" patented technology

The invention relates to application of a rhizoma curculiginis extract in preparing an anti-depression medicament, so as to effectively solve the problem of preparing anti-depression medicaments and realizing an application of a rhizoma curculiginis extract in preparing an anti-depression medicament. According to the application of the rhizoma curculiginis extract in preparing the anti-depression medicament, the rhizoma curculiginis extract is prepared by virtue of the following steps: crushing rhizoma curculiginis into coarse powder, soaking with ethanol, and performing reflux extraction; decompressing the filtrate to reclaim ethanol until the liquid does not have ethanol smell, concentrating, and dispersing the concentrate with distilled water to obtain a dispersant; loading the dispersant onto macroporous adsorption resin, eluting with distilled water, and removing the aqueous liquid; continuously eluting with ethanol, and removing the ethanol eluent; eluting with ethanol, collecting the ethanol eluent, reclaiming ethanol in reduced pressure, drying and crushing. The rhizoma curculiginis extract has an anti-depression effect and can be used for effectively preparing the anti-depression medicament, so that the application of the rhizoma curculiginis extract in preparing the anti-depression medicament can be realized.

The invention relates to application of cynomorium songaricum extractive in the preparation of an antidepressant drug, can effectively solve the problem about the preparation of the antidepressant drug, and realizes the application of the cynomorium songaricum extractive in the preparation of the antidepressant drug. The cynomorium songaricum extractive is prepared through the following steps: taking cynomorium songaricum medicinal materials, smashing the cynomorium songaricum medicinal materials into coarse powder, soaking with ethyl alcohol, performing the reflux extraction, recycling the ethyl alcohol from the filtrate through pressure reduction until the alcohol taste is eliminated, so as to obtain a cynomorium songaricum extracting solution; soaking macroporous resin with ethyl alcohol, and performing wet-process packing; dispersing the cynomorium songaricum extracting solution into dispersion liquid by using distilled water, adjusting the pH value to 4.5, adding macroporous resin columns, eluting by using distilled water, and removing the eluent; continuously eluting by using ethyl alcohol, and removing the eluent; then eluting by using ethyl alcohol again, collecting the ethyl alcohol eluent, recycling the ethyl alcohol through pressure reduction, drying, and smashing, so as to obtain the finished product. According to the invention, the prepared cynomorium songaricum extractive has the anti-depression function, and can be effectively used for preparing the antidepressant drug, so that the application of the cynomorium songaricum extractive in the preparation of the antidepressant drug is realized.

The invention relates to a method for extracting purified total flavonoids from lindera reflexa hemsl by means of macroporous absorption resin, which can effectively solve the problem in extracting purified total flavonoids from lindera reflexa hemsl so as to prepare drugs for curing gastric ulcer, easing pain and resisting inflammation. The method is as follows: grinding the lindera reflexa hemsl to powder, adding ethanol and extracting through ultrasonication, recovering the ethanol under reduced pressure until the extract becomes non-alcoholic so as to get concentrated solution, and addingwater to dilute the concentrated solution to get lindera reflexa hemsl extractive solution; soaking macroporous absorption resin in ethanol, washing with ethanol, washing again with distilled water until the macroporous absorption resin becomes non-alcoholic, and then loading the macroporous absorption resin into a column; extracting the supernatant of the lindera reflexa hemsl extractive solution, after that, standing, washing with purified water to get rid of the impurities, eluting through ethanol, collecting the eluent, and finally recovering the ethanol under reduced pressure. In this way, purified total flavonoids from the active part of the root of the lindera reflexa hemsl can be obtained. The method provided by the invention is simple, stable and reliable, and the total flavonoids extracted from the lindera reflexa hemsl through the method can be effectively used in preparing the drugs for curing gastric ulcer, easing pain and resisting inflammation. The invention develops the medical value of the lindera reflexa hemsl and makes innovation in the field of medicine.

The present invention discloses a drug for treatment of type II diabetes, and the drug comprises medicinal ingredients of gentiopicroside and / or sweroside, or comprises the medicinal ingredients of a panax notoginseng total extract including the two components. Experiments show that the panax notoginseng total extract, gentiopicroside and sweroside two monomers and a mixture of the gentiopicroside and the sweroside have the role of good resistance to the type II diabetes, and can inhibit phosphorylation of type II diabetes target spot PEPCK and Akt, Erk and the like. The effect of the mixed gentiopicroside and sweroside is better than the effect of other monomer and single use of the gentiopicroside and sweroside two monomers. A new research channel for treatment of type II diabetes is opened, and medicinal value of the panax notoginseng is further developed.

The invention discloses a preparation method of durio zibethinus murr shell extract. The method comprises the following steps: (1), taking white flesh endocarp of durian fruit skin, cleaning, cutting and drying the white flesh endocarp to constant weight; (2), crushing; (3), adding powder obtained in the step (2) into an ethyl alcohol extractant according to certain ratio of material to solution; (4), performing reflux extraction on a thermostat water bath; (5), performing filtration under reduced pressure through a Buchner funnel, combining filtrate, performing concentration through a rotary evaporator, drying, thereby obtaining the durio zibethinus murr shell extract. The invention further discloses application of the durio zibethinus murr shell extract to preparation of anti-inflammatory, cough suppressant and analgesic drugs, and the preparation of the drugs adopts capsules, tablets, granules, sirup, oral preparation and injection.

The invention relates to external traditional Chinese medicine formula essential oil for treating senile skin itch and can solve the problem of drug use for treatment of senile skin itch effectively.The technical scheme is as follows: the essential oil is prepared from liquorice root essential oil, angelica sinensis essential oil, radix sophorae flavescentis essential oil, radix angelicae essential oil, snakegourd fruit essential oil and mentholum in a ratio of (2.5-3.5): (2.5-3.5): (2.5-3.5): (1.8-2.2): (1.8-2.2): (1.8-2.2), wherein the components are uniformly mixed. The essential oil provided by the invention is rich in raw material, easy to produce and prepare, convenient to use and good in effect, can be used for treating senile skin itch effectively, is innovation in medicine for treating senile skin itch, expands the medicinal value and the economic value of liquorice root, angelica sinensis, radix sophorae flavescentis, radix angelicae, snakegourd fruits and mentholum, and isremarkable in economic and social benefits.

The invention relates to a method for extracting fenugreek extract from fenugreek and application of the fenugreek extract. The method comprises the following steps: crushing fenugreek, firstly addingpetroleum ether, carrying out reflux extraction, degreasing and removing petroleum ether; volatilizing petroleum ether in medicine residues, adding alcohol into the medicine residues, for soaking themedicine residues, carrying out reflux extraction and filtering to obtain primary filtrate; adding alcohol into the medicine residues again, carrying out reflux extraction and filtering to obtain secondary filtrate, combining the primary filtrate with the secondary filtrate, recycling alcohol, adding distilled water and dispersing to obtain a dispersion solution, putting the dispersion solution on resin, firstly eluting by using distilled water and removing water phase; eluting by using alcohol again and removing eluante; eluting the medicine residues by using alcohol again, collecting alcohol eluante, carrying out pressure-reduced recycling of alcohol till no alcohol taste exists, carrying out freeze-drying and crushing to obtain extract which is the fenugreek extract. The application ofthe fenugreek extract to preparation of medicines for treating perimenopausal syndrome is achieved. The fenugreek extract is abundant in raw materials; the preparation method of the fenugreek extractis scientific and is easy to operate; the extraction of total flavonoid from fenugreek can be effectively solved; medicinal value and commercial value of fenugreek are developed; the fenugreek extract has obvious economic and social benefits.

The invention relates to application of total flavonoids of pueraria lobata in preparation of medicines for treating repeated ischemia. The problem that the total flavonoids of pueraria lobata are extracted from pueraria lobata and serve as the unique active ingredient in the preparation of the medicines for treating repeated ischemia can be effectively solved. The total flavonoids of pueraria lobata are prepared by the steps: grinding the pueraria lobata into coarse powder, performing reflux extraction with ethyl ether and degreasing, and removing the ethyl ether; volatilizing the ethyl ether from decoction dregs of the pueraria lobata, adding ethanol with a mass concentration of 80% for soaking, performing reflux extraction filtering, recovering the ethanol from the filtrate under reduced pressure until any alcohol does not exist, adding distilled water to disperse until dispersion equivalent to 0.3g/mL of the raw drug content is obtained, enabling the dispersion to pass through an AB-8 type macroporous resin, sequentially eluting with the distilled water, ethanol with the mass concentration of 10% and ethanol with the mass concentration of 80%, collecting the 80% of ethanol eluent, performing reduced pressure recovery on the ethanol until any alcohol does not exist, performing freeze drying, and grinding, thereby obtaining the total flavonoids of pueraria lobata. According to the preparation method disclosed by the invention, the total flavonoids of pueraria lobata can be effectively extracted from the pueraria lobata and are effectively used for treating the repeated ischemia, the novel application and medicinal values of the pueraria lobata are developed, and obvious economic and social benefits are achieved.

The invention relates to a novel compound extracted from burdock leaves and capable of protecting alcoholic liver injury as well as a preparation method and application of the novel compound, which can effectively solve the problem of preparing the novel compound capable of protecting alcoholic liver injury from burdock leaves and developing the novel application of the medicinal value of burdock leaves. The method comprises the following steps: soaking the burdock leaves in water, filtering, concentrating, sequentially extracting with ethyl acetate, concentrating an ethyl acetate extract under reduced pressure, carrying out silica gel column chromatography, carrying out gradient elution with dichloromethane-methanol, recovering a solvent under reduced pressure, then carrying out MCI column chromatography, carrying out gradient elution with a methanol aqueous solution, combining eluents, drying, and recrystallizing in methanol so as to obtain the novel compound extracted from burdock leaves and capable of protecting alcoholic liver injury. The preparation method is easy to operate, the guidance quality is high, the separation speed is high, the product purity is high, the compound can be effectively used for preparing the medicine for reducing the fat and protecting the alcoholic liver injury, the new application and the medicinal value of the burdock leaves are developed, and the economic and social benefits are huge.

The invention relates to a compound with cholesterol lowering activity extracted from burdock leaves and a preparation method and application thereof, can effectively solve the problem of extracting a new compound with lipid lowering activity from the burdock leaves and realize the application of the new compound in preparing lipid lowering medicaments. The preparation method comprises the steps of adding water into burdock leaves, conducting boiling and extraction, conducting concentration, feeding an obtained concentrate into an AB-8 column, conducting elution with water, 30% ethanol and 70% ethanol in sequence, collecting 70% ethanol eluent, recovering the solvent under reduced pressure, dispersing an obtained extractum by adding water, conducting extracting with n-butyl alcohol, recovering the solvent under reduced pressure, carrying out silica gel column chromatography, carrying out dichloromethane/methanol gradient elution, recovering the solvent under reduced pressure, carrying out secondary silica gel column chromatography, carrying out gradient elution with petroleum ether-ethyl acetate, collecting 100:70 eluate, recovering the solvent under reduced pressure, carrying out MCI column chromatography, carrying out methanol aqueous solution gradient elution, collecting 40% methanol eluate, recovering the solvent under reduced pressure, and carrying out reverse semi-preparation by using a YMC-Pack ODS-A column to obtain the compound with the activity of reducing cholesterol. The preparation method is easy to operate, high in guidance quality, high in separation speed and high in product purity.

The invention relates to application of cortex moutan extract in preparation of a hypoglycaemic agent and aims at solving the problem of preparation of the hypoglycaemic agent. According to the technical scheme, the cortex moutan extract is obtained by the following steps: taking a cortex moutan medicinal material, smashing cortex moutan into coarse powder, adding NaCl aqueous solution, soaking, then distilling and extracting, collecting distillate, cooling to room temperature, refrigerating, after cortex moutan phenol crystals are separated out, filtering to obtain primary crystals; adding NaCl into filtrate, distilling again, collecting distillate with the volume of being three times that of the filtrate, refrigerating, staying overnight, filtering to obtain secondary crystals, putting the primary crystals and the secondary crystals together, and drying under reduced pressure, so that the cortex moutan extract is obtained, wherein cortex moutan phenol mass content is more than 80%. Raw materials are available, a preparation method is simple, the obtained cortex moutan extract is effective and can be used for preparing the hypoglycaemic agent, so that the application of the cortex moutan extract in the preparation of the hypoglycaemic agent is realized; meanwhile, the cortex moutan extract also can be used for further realizing preparation of a drug used for treating diabetes, so that medicinal value of cortex moutan is increased and a new application of the cortex moutan is developed.

The invention relates to compounds A and B extracted from Common Macrocarpium Fruit as well as a preparation method and application thereof, which can effectively solve the problems of preparation of new compounds A and B from Common Macrocarpium Fruit and application in preparation of anti-inflammatory drugs. The method includes steps that water is added into Common Macrocarpium Fruit for boiling extraction, wherein the extract is concentrated under reduced pressure, the concentrated extract is loaded on a D101 macroporous adsorption resin column, elution is carried out with water and 30% ethanol in sequence, and the 30% ethanol part eluent is collected; then vacuum concentration is carried out to obtain an extract Fr.30% EtOH, and silica gel column chromatography separation and dichloromethane-methanol gradient elution are performed to collect a 100:5 eluent; vacuum concentration is carried out toobtain an extract Fr.30% EtOH-4; ODS column chromatography separation and then vacuum gradient elution with methanol-water are carried out to collect a 30: 70 eluent, and then vacuum concentration is carried out to obtain an extract Fr.30% EtOH-4-3; and Sephadex LH-20 column chromatography separation is conducted, methanol elution is carried out, the solvent is recovered under reduced pressure, and recrystallization is performed to obtain the compounds A and B. The method is easy to operate, high in guidance quality and high in product purity, the compound can be effectively used for preparing the anti-inflammatory medicine, and the new application and the medicinal value of the Common Macrocarpium Fruit are developed.

The invention relates to application of common cephalanoplos herb total flavones in preparation of a medicine used for treating repeated cerebral ischemia and focal cerebral ischemia. The problem that the common cephalanoplos herb total flavones are taken as a unique active ingredient for preparing the repeated cerebral ischemia and focal cerebral ischemia can be effectively solved. The common cephalanoplos herb total flavones are obtained by smashing common cephalanoplos herb into coarse powder, carrying out reflux extraction and degreasing by virtue of diethyl ether, volatilizing diethyl ether from medicine residue, adding 80% ethanol and soaking, carrying out reflux extraction, filtering, carrying out reduced pressure ethanol recovery on filtrate until no alcohol flavor is left, adding distilled water, dispersing into dispersion liquid equivalent to containing crude drug according to a ratio of 0.3g/mL, loading the dispersion liquid on an AB-8 type macroporous adsorption resin, sequentially eluting with the distilled water, 10% ethanol and 80% ethanol, collecting 80% ethanol eluent, carrying out reduced pressure ethanol recovery until no alcohol flavor is left, carrying out freeze drying, and smashing, so that the common cephalanoplos herb total flavones are obtained. The application provided by the invention has the advantages that extraction of the common cephalanoplos herb total flavones from the common cephalanoplos herb can be effectively solved, the common cephalanoplos herb total flavones can be effectively used for treating the repeated cerebral ischemia and focal cerebral ischemia, new application and pharmaceutical value of the common cephalanoplos herb are developed, and obvious economic and social benefits are realized.

The invention relates to a preparation method of two diflavonoid compounds with antitumor activity in sinopodophyllum emodi and application thereof. The preparation method of the two novel diflavonoidcompounds with the antitumor activity in the sinopodophyllum emodi, namely sinodiflavonoid A and sinodiflavonoid B, comprises the following steps: preparing a crude extract, preliminarily separatingthrough combination of silica gel column chromatography and gel column chromatography, and purifying by high performance liquid chromatography. The preparation method is stable, reliable and high in efficiency; by the preparation method, the two novel diflavonoid compounds with the antitumor activity, namely the sinodiflavonoid A and the sinodiflavonoid B, can be quickly separated from the sinopodophyllum emodi; in addition, results of an activity test show that the sinodiflavonoid A and the sinodiflavonoid B have cytotoxic activity for human cervical cancer cells (HeLa), and can be effectively applied to preparation of medicines for resisting cervical cancer, so that the medicinal value and novel application of the sinopodophyllum emodi are opened up, the commercial value of the sinopodophyllum emodi is increased, and the economic and social benefits are huge.

The invention relates to application of honeysuckle extract in the preparation of drugs for treating repeated cerebral ischemia and focal cerebral ischemia. The honeysuckle extract can be effectively extracted from honeysuckle and used as the only active component in the preparation of the drugs for treating the repeated cerebral ischemia and the focal cerebral ischemia. A preparation method of the honeysuckle extract includes: crushing the honeysuckle into crude powder, performing ethyl ether extraction and degreasing, volatilizing the ethyl ether in dregs, soaking the dregs with 70% ethanol, performing reflux extraction, filtering, performing pressure reduction on the filtrate to recycle the ethanol until no alcohol flavor exists, dispersing with distilled water to obtain dispersion liquid containing 0.3g/mL raw drugs, using acetic acid to regulate pH, using HPD-600 or AB-8 type macroporous adsorption resin to treat the dispersion liquid, eluting with 30% ethanol, concentrating eluent, and performing freeze drying and crushing to obtain the honeysuckle extract. The application has the advantages that the honeysuckle extract can be effectively extracted from the honeysuckle and effectively used for treating the repeated cerebral ischemia and the focal cerebral ischemia, the new application and medicinal value of the honeysuckle are exploited, and evident economic and social benefits are achieved.

The invention relates to descurainia sophia total-flavone tablets for relieving cough, eliminating phlegm and relieving asthma. The problem of preparation of cough-relieving, phlegm-eliminating and asthma-relieving drugs by utilizing descurainia sophia total flavones as a raw material can be effectively solved. The descurainia sophia total-flavone tablets are prepared from, by weight, 45-49% of beta-cyclodextrin, 33-37% of maltodextrin, 1.5-2.5% of xylitol, 0.8-1.2% of magnesium stearate and 13-17% of descurainia sophia total flavone, wherein the descurainia sophia total flavones, a quarter of beta-cyclodextrin and a third of maltodextrin are mixed together and are prepared into 1.2 g/mL of mixed solution with distilled water, the distilled water is subjected to spray drying to obtain particles, the xylitol, the magnesium stearate, three quarters of beta-cyclodextrin and two thirds of maltodextrin are added into the particles, and the mixture is pressed into the descurainia sophia total-flavone tablets. The descurainia sophia total-flavone tablets are scientific and reasonable in formula and convenient to use, has the effects of relieving cough, eliminating phlegm and relieving asthma, is effectively used for treating cough and asthma and eliminating excessive phlegm and is good in effect, and the medicinal value of descurainia Sophia is developed.

The invention provides application of forsythia leaf extract to preparation of a drug for treating mild diabetes. Forsythia leaves are smashed into coarse powder, firstly petroleum ether (30-60 DEG C) is added, reflux extraction is conducted for 1 hour, degreasing is conducted, and a petroleum ether extracting solution is discarded; dry volatilization of the petroleum ether is conducted on forsythia leave medicine residue, ethyl alcohol is added and soaking is conducted for 0.5 hour, reflux extraction is conducted for 1 hour, filtering is conducted for two times, filter liquid is combined for two times, the ethyl alcohol is reclaimed till no alcohol taste exists, freezing, drying and smashing are conducted, and the forsythia leaf extract is obtained. According to the application of the forsythia leaf extract to preparation of the drug for treating the mild diabetes, raw materials are rich, the preparation method is simple, the cost is low, the drug is convenient to take, the forsythia leaf extract serves as the only active component, can be effectively used for treating the mild diabetes, the novel application and medical value of the forsythia leaves are developed, and the application of the forsythia leaf extract to preparation of the drug for treating the mild diabetes is a creation of the drug for treating the mild diabetes, and has significant economic and social benefits.

The invention relates to a preparation method for two novel compounds with antitumor activity extracted from isodon excisoides and an application of the two novel compounds. The novel compounds are extracted from the isodon excisoides and are applied to the preparation of antitumor drugs. The method comprises the steps: adding water into the isodon excisoides, carrying out boiling extraction, introducing an extract sample to a macroporous adsorption resin column, and carrying out gradient elution by using water and ethanol, so as to obtain Fr. A, Fr. B, Fr. C and Fr. D; subjecting part of Fr. C to gel column chromatography and methanol-water gradient elution, so as to obtain Fr. C1, Fr. C2, Fr. C3 and Fr. C4; and subjecting part of Fr. C2 to silica-gel column chromatography and petroleum ether-acetone and methanol gradient elution, so as to obtain Fr. B1-1, Fr. B1-2, Fr. C2a, Fr. C2b, Fr. C2c and Fr. C2d, subjecting Fr. C2c to methanol recrystallization so as to obtain an acetonitrile-water for white powder as eluate, carrying out semipreparative HPLC purification, collecting chromatographic peaks at 56.4min and 61.2min, separately placing products in a solvent, and carrying out anhydrous sodium sulfate dehydrating and nitrogen gas drying-up, thereby obtaining a compound 1 and a compound 2. The preparation method provided by the invention is easy in operation, high in orienting property, high in separating rate, high in efficiency and high in product purity and can be effectively used for preparing the antitumor drugs.