103 results about "Phenol derivative" patented technology

The present invention provides a fiber structure having excellent antibacterial properties and washing durability, and a method for producing the same. [Solution] A textile structure having polyamide fibers and containing a dye, a quinoline-based compound, and a phenol derivative, wherein the textile structure contains 0.04% by mass or more of the quinoline-based compound relative to the mass of the textile structure, and even after 10 standard washes in accordance with the "SEK Mark Textile Product Washing Method," the textile structure contains 0.04% by mass or more of the quinoline-based compound relative to the mass of the textile structure, and 0.20% by mass or more and 4.00% by mass or less of the phenol derivative relative to the mass of the textile structure.

The present invention is directed to a composition including a Tryptophol derivative, a 4-Ethyl-Phenol derivative, or a combination thereof, and a method of using same, such as for treating a subject in need of modulation of blood coagulation.

The invention relates to the field of pipes, and discloses a high-strength CPVC pipe and a preparation method thereof.The pipe comprises CPVC resin, modified multi-walled carbon nanotubes, modified nano silicon dioxide and auxiliaries; the modified multi-walled carbon nanotubes are prepared by grafting phosphorus-containing cardanol derivative based benzoxazine and oxidized multi-walled carbon nanotubes; phosphorus-containing cardanol derivative benzoxazine reacts with 1, 5-naphthylenediamine to prepare an aldehyde cardanol intermediate, the aldehyde cardanol intermediate is prepared by reacting paraformaldehyde with hydrogenated cardanol, the obtained cardanol derivative and DOPO are subjected to addition, and then the obtained phosphorus-containing cardanol derivative reacts with paraformaldehyde and 3-aminopropyltriethoxysilane to prepare the flame retardant. The modified nano silicon dioxide is prepared by introducing polyethylene glycol into the surface of isocyanated nano silicon dioxide and grafting with 3, 5-bis (tert-butyl)-4-hydroxybenzene propionyl chloride, and the pipe prepared by the invention is high in tensile strength and impact strength and has good long-acting oxidation resistance, high temperature resistance and flame retardance.

This invention provides a novel GABA structure with better efficacy, reduced side effects, and greater safety for clinical use. A This invention relates to receptor agonists, specifically a phenol derivative, its preparation method, and its use in the central nervous system. The phenol derivative provided by this invention offers more and better drug options for inducing or maintaining anesthesia in animals or humans, promoting sedation and hypnosis, and treating and / or preventing anxiety, nausea, vomiting, migraines, seizures, epilepsy, neurodegenerative diseases, and other central nervous system-related disorders.

The invention discloses a synthesis method of Peniterpheyl A. According to synthesis of a key structural unit furan ring, diphenyl ether is synthesized through a simple heating substitution reaction of a phenol derivative and a fluorobenzene derivative, then C-C direct oxidative coupling of double benzene rings in a molecule is achieved under a Pd / Ag catalytic system to synthesize the furan ring, and due to steric hindrance and guiding group effects, the furan ring can be synthesized into the furan ring. The product has high selectivity, does not need harsh reaction conditions, has simple synthesis steps, is suitable for large-scale production, does not need to widely screen specific strains and fermentation conditions compared with a method for obtaining a low-amount target compound from microbial fermentation separation, is simple and efficient, and can guarantee a large amount of compounds required by subsequent research and development.

The application discloses a porphyrin-eugenol derivative with antitumor activity, uses DPBF to detect the yield of singlet oxygen, and in-vitro antitumor activity test shows that the compound has good activity. The porphyrin-coumarin compound can realize the synergistic treatment of phototherapy and chemotherapy, in addition, the insertion of metal Zn in the porphyrin can also enhance the antitumor activity of the compound. Thus, the compound can be used as an active ingredient of an antitumor drug, and has good development and application prospect.

This invention discloses a piperazine substituted phenol derivative and its applications in pharmaceutical chemistry. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum anesthetic effective dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

The application discloses a kind of polysubstituted phenol derivatives and electrochemical preparation method thereof, which uses 2-(benzo[d]thiazole-2-yl)-4-substituted phenol, substituted pyrazole or benzimidazole as raw material, tetrabutylammonium tetrafluoroborate as electrolyte, a mixture of hexafluoroisopropanol and dichloromethane (volume ratio 7:3) as solvent, direct electrolysis reaction under air atmosphere at room temperature to obtain the target product shown in formula one or formula two. Research has found that such products have good solid fluorescence and exhibit aggregation-induced emission properties in tetrahydrofuran and water systems. The method of the application has the advantages of simple operation, good compatibility of substrate functional groups, mild conditions, low production process cost and environmental friendliness.

The object of the invention is a nitroxyl polyphenol derivative of formula:wherein Q is a group derived from a polyphenol;L is an ester linking group containing 1 to 3 carbon atoms;A is a 5- or 6-membered heterocyclic group containing one nitrogen atom which is in the form of nitroxyl radical (NO·), in which both carbon atoms adjacent to the nitroxyl radical are substituted independently of each other with one or two C1-C3 alkyl groups; andn is an integer of 1 to 5.The object of the invention is also methods for the preparation of the above-defined derivative and a use thereof as an antioxidant agent, in particular an antiaging agent.

The purpose of the present invention is to provide: a photochromic compound having excellent temperature dependence and fading speed; a phenol derivative that can be used as an intermediate of the photochromic compound; a curable composition containing the photochromic compound; an optical article; according to one embodiment, a photochromic compound having a skeleton represented by formula (1) is provided. In formula (1), M is C, Si, or Ge. Ring A is a substituted or unsubstituted aromatic ring, a substituted or unsubstituted aromatic heterocyclic ring, or a substituted or unsubstituted fused polyring in which an aromatic ring or an aromatic heterocyclic ring is fused to these rings. Z1 represents a group represented by formula (1a) or a group represented by formula (1b).

The invention provides a resorcinol derivative phospholipid complex dispersion as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. A resorcinol derivative, an antioxidant, lecithin, sodium surfactin and water are used as raw materials, a strongly hydrophobic phospholipid compound is formed through interaction between hydrophilic ends of the lecithin and strong molecules of phenolic hydroxyl groups of the resorcinol derivative, then a hydrophilic cyclopeptide layer is modified on the surface of the phospholipid compound through the sodium surfactin surfactin, and the hydrophobic phospholipid compound is prepared. The dispersity of the phospholipid complex in water is improved, the stability of the resorcinol derivative can be effectively improved, and the problem of high-temperature discoloration is avoided. The particle size of the resorcinol derivative phospholipid complex dispersion provided by the invention is less than 200nm, and the resorcinol derivative phospholipid complex dispersion has good hydrophilicity and better transdermal permeation absorption effect.

The invention discloses a 2-styryl phenol derivative and a hypoglycemic effect thereof, and belongs to the technical field of medicine preparation. According to the present invention, the early stage research results show that the salvianolic acid A has strong alpha-glucosidase inhibition effect; a series of styryl derivatives with novel structures are designed and synthesized by taking a 1, 2-diarylethene structure in a salvianolic acid A structure as a target, and alpha-glucosidase and PTP1B inhibitory activity of various derivatives are deeply studied. The 2-styryl phenol derivative with alpha-glucosidase and PTP1B double-target inhibitory activity is obtained, and a material basis is provided for prevention and treatment of T2DM and complications thereof.

The invention discloses an application of an improved isoluminol luminescent substrate in a MaglumiX8 chemiluminescence immunoassay system, and belongs to the technical field of in vitro diagnostic reagents. The luminescent substrate comprises an alkaline solution containing a metal leaf line complex and a derivative thereof, and a piperazine phenol derivative, and a peroxide solution containing urea and stannate. According to the invention, a metal leaf line substance is added into an alkaline solution, an active structure is stabilized through coordination modification, a reaction with hydrogen peroxide is promoted, a chemiluminescence signal is enhanced, and the luminous efficiency and the detection sensitivity are improved; by adding the piperazine phenol derivative, lasting glow of isoluminol is realized, signal stability is ensured, and result reliability is improved. In a hydrogen peroxide system, a urea / stannate stabilizer is added, so that the stability of a substrate is improved. Experimental verification shows that the substrate has high accuracy correlation with an original reagent, excellent precision and stable performance after being stored at room temperature for 24 months, and is suitable for the detection fields of hormones, tumor markers and the like.

The invention relates to a method for preparing a cycloheptatrienone derivative, and belongs to the technical field of bioengineering. The invention provides a method for preparing a cycloheptatrienone derivative, which is based on a framework editing strategy of biological catalysis and comprises the following steps of: performing biological catalysis on a substrate and an auxiliary substrate by using a phenol derivative as a substrate and nitroalkane as an auxiliary substrate and using multi-copper oxidase and / or a microorganism for producing the multi-copper oxidase as a catalyst to obtain the cycloheptatrienone derivative. The auxiliary substrate is used as a C1 unit to be inserted into the skeleton of the aromatic ring substrate for editing, so that the cycloheptatrienone derivative is generated. According to the method, multi-copper oxidase is used as a catalyst, nitroalkane which is simple, easy to obtain, safe and highly stable is used as a C1 unit, and a phenol derivative is successfully converted into the cycloheptatrienone derivative. According to the method, a single carbon insertion mediated skeleton editing biological catalysis strategy is constructed, the strategy breaks through the limitation of a traditional carbene insertion reaction, and the method has a great application prospect in skeleton modification in the field of chemical and biological catalysis.

Provided are a highly sensitive detection method for a target substance and a reagent for inspection thereof. Specifically, provided is a method of detecting a target substance that is a substance related to an enzyme reaction, the method including: mixing a specimen liquid that may contain the target substance and a reagent to obtain a liquid sample containing hydrogen peroxide, a peroxidase, a phenol derivative and a plurality of luminescent particles each having a binding functional group; aggregating the plurality of luminescent particles through binding of the binding functional groups of the luminescent particles based on a reaction of the hydrogen peroxide, the peroxidase and the phenol derivative in the liquid sample, which occurs when the target substance is present in the liquid sample; and obtaining a value related to fluorescence anisotropy of the liquid sample.

Provided are a highly sensitive detection method for a target substance and a reagent for inspection thereof. Specifically, provided is a method of detecting a target substance that is an enzyme reaction-related substance, the method including: a first step of mixing a specimen containing the target substance and a reagent to obtain a liquid sample containing hydrogen peroxide, a peroxidase, a phenol derivative, a luminescent particle and a plurality of hydrophilic polymers each having a binding functional group; a second step of generating an aggregate of the hydrophilic polymers including the luminescent particle through binding of the binding functional groups of the hydrophilic polymers based on a reaction of the hydrogen peroxide, the peroxidase and the phenol derivative, which occurs when the target substance is present in the liquid sample; and a third step of obtaining a value related to fluorescence anisotropy of the liquid sample in the second step.

This invention relates to a method for synthesizing 2-(indole-3-yl)phenol and its derivatives. This invention utilizes iodine-based catalysts, oxidants, and acid additives to achieve a highly selective one-pot reaction of indole and cyclohexanone compounds to obtain 2-(indole-3-yl)phenol and its derivatives, yielding structurally stable products with excellent chemical properties and byproducts. The method of this invention features a simple reaction system, mild reaction conditions, fewer reaction devices, convenient experimental operation, wide availability of raw materials, good atom economy, and no need for transition metal catalysts, providing a new synthetic route for the synthesis of 2-(indole-3-yl)phenol compounds. The 2-(indole-3-yl)phenol derivatives and their synthesis method of this invention can be used in the pharmaceutical production field.

A method of preparing a thiomethylphenol derivative is disclosed, the method including: (a) carrying out a primary reaction of a phenol derivative represented by the following Chemical Formula 2, a mercaptan derivative represented by R4SH, and paraformaldehyde at a reaction temperature T1 under conditions in which a heterocyclic base having 3 to 10 carbon atoms and an acid are simultaneously present; and (b) carrying out a secondary reaction at a reaction temperature T2 to prepare a thiomethylphenol derivative represented by the following Chemical Formula 1, wherein T1<T2 is satisfied.

The application discloses a cannabidiol derivative and application thereof, and belongs to the technical field of medicinal chemistry. The structural general formula of the cannabidiol derivative is shown as formula (I): (I) R1 is selected from one of hydrogen, chlorine, bromine, a hydroxyl group, a cyano group, an acetoxy group, an acryloyloxy group, a benzoyl group, an acetamide group, an acrylamide group, a propiolamide group, an ethyl thiourea group, a 3-chloro-2,2-dimethylpropionyl group, a 2-ethylsulfonamide acetyl group, a 2-ethylsulfonamide-N-(2-amino-2-oxoethyl) acetyl group, a methylsulfonyl group, an ethylsulfonyl group, a vinylsulfonyl group, an alkyne propylsulfonyl group, a phenylsulfonyl group and a styrylsulfonyl group; and R2 is selected from one of C2-C5 alkyl groups. The cannabidiol derivative disclosed by the application has significantly improved anti-neuroinflammatory activity, significantly reduced cytotoxicity, and a generally improved treatment index of more than 10 times, or even more than 260 times, compared with cannabidiol.

The invention relates to the technical field of water pollution treatment, in particular to a method for photocatalytic reduction of phenols in cooperation with Cr (VI). The method comprises the following steps: mixing wastewater containing phenol pollutants and Cr (VI) with a secondarily calcined g-C3N4 photocatalyst, and carrying out photocatalytic degradation reaction to realize oxidative degradation of phenols and reduction of Cr (VI); the phenol pollutants are phenol or phenol derivatives with substituent groups, and the substituent groups comprise electron donating groups or electron withdrawing groups. A g-C3N4 photocatalyst subjected to secondary calcination treatment is added into wastewater containing phenolic organic matters and Cr (VI), the electron supply capacity is regulated and controlled through substituent group types (electron donating groups and electron withdrawing groups) of phenolic molecules under the irradiation of visible light, a structure-oriented self-driven photocatalytic mechanism is disclosed, effective separation of photo-induced electron holes is driven, and the photocatalytic efficiency is improved. And oxidative degradation of phenols and efficient reduction of Cr (VI) are synchronously realized.

The present application belongs to the technical field of health care products, and particularly relates to an anti-anxiety gamma-aminobutyric acid composition and a preparation method thereof. The anti-anxiety gamma-aminobutyric acid composition comprises the following components in parts by weight: 1-2 parts of a paeonol derivative, 0.1-0.5 parts of gamma-aminobutyric acid, 0.1-0.3 parts of astaxanthin, and 0.01-0.05 parts of a sea star saponin. The present application uses the gamma-aminobutyric acid, the paeonol derivative and the sea star saponin in combination. The paeonol derivative promotes passive diffusion of the gamma-aminobutyric acid into intestinal epithelial cells through a cell membrane, thereby greatly improving the ability of the gamma-aminobutyric acid to passively diffuse through the cell membrane of the intestinal epithelial cells. The sea star saponin has the effects of sedation, anti-anxiety and regulation of insomnia, and can effectively promote absorption of the gamma-aminobutyric acid. The present application can effectively promote absorption of active substances and has high bioavailability. The composition has the advantages of small dosage, good anti-anxiety effect, prolonged sleep duration and the like.

To provide a method for producing a compound suitable for use as a perfume and / or aroma having an aromatic note of musk.SOLUTION: A process for preparing a compound of formula (I) comprising the steps of: (A) etherifying a phenol derivative to obtain an allyl ether derivative; (B) Claisen rearrangement of the ether from step (A) followed by cyclisation; (C) acetylating or formylating the intermediate from step (B); wherein steps (A) and (B) are carried out in a one pot reaction. Wherein R1, R2, R3 and R4 represent hydrogen, methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, tert-butyl, iso-butyl, acetyl, formyl or SELECTED DRAWING: None

The present invention relates to novel solid display forms of phenol derivatives characterized by rounded and flattened portions. The resulting compositions have advantageous properties for storage, handling, and compound flow. The present invention also relates to methods for preparing these solids and their use, particularly in the polymer and agri-food industries. [Selection diagram] Figure 5

This invention discloses an age-resistant photochromic dye and its preparation method, belonging to the fields of fine chemical synthesis and optical functional materials technology. In this invention, naphthalene ketone is reacted with succinate and acetic anhydride to generate a hyperconjugated naphthol derivative. The naphthol derivative then reacts with the aforementioned hydroxyl-functionalized diarylkynyl alcohol to generate a hyperconjugated naphthopyran compound. This synthetic process is easy to operate. Furthermore, the obtained hyperconjugated naphthopyran compound exhibits a rapid fading rate and good age resistance, making it suitable for applications in photochromic lenses, textiles, anti-counterfeiting, coatings, and other fields.

Provided is a chiral cannabidiol (CBD) derivative drug, comprising four chiral derivatives, i.e., (7S)-(-)-CIAC001, (7R)-(-)-CIAC001, (7S)-(+)-CIAC001, and (7R)-(+)-CIAC001; and a use of the four chiral derivatives of CBD in the treatment of neuroinflammation and opioid addiction. Also disclosed are anti-neuroinflammation effects and the ability to regulate the activity of pyruvate kinase M2 (PKM2) of CBD analogs.

The invention belongs to the technical field of environmental analysis chemistry and new material preparation, and particularly relates to a sulfuryl-containing covalent organic framework material as well as a preparation method and application thereof. The sulfuryl-containing covalent organic framework material (TpSD) is shown in the following formula I. The material disclosed by the invention is prepared from 1, 3, 5-trialdehyde phloroglucinol and 4, 4 '-diaminodiphenyl sulfone. The material is novel in structure, and shows the characteristics of large specific surface area, regular pore structure and high stability. In addition, a target object and sulfuryl in the material can form a hydrogen bond, so that the adsorption effect is further enhanced. The material can be applied to quantitative separation and enrichment of tetrabromobisphenol S derivatives in environmental water samples, can solve the problems of complex matrix interference and low sensitivity of detection instruments during analysis of trace organic matters in current environmental water samples, has stable properties, and can be reused.

The invention discloses a method for synthesizing a pyrazole methylene phenol derivative, which comprises the following steps: by taking p-methylphenol and a derivative thereof as well as pyrazole and a derivative thereof as raw materials, reacting under mild conditions without a metal catalyst and a stoichiometric amount of redox reagent; the corresponding para-substituted phenol derivative is prepared through a one-step electrosynthesis reaction by stirring an easily available electrode under the conditions of room temperature, anhydrous cesium carbonate, an acetonitrile solvent and constant current. The method provided by the invention has the advantages of low price, reaction at room temperature and mild reaction conditions, provides a convenient way for oxidation of p-methylphenol, the obtained p-substituted phenol is a key structure motif of many natural products and drug intermediates, and the method is simple and convenient in synthesis operation, environment-friendly, free of special protection and wide in industrial production prospect.

The invention discloses a preparation method of a phenol derivative capable of effectively inhibiting staphylococcus aureus, and belongs to the technical field of synthesis and application of medical intermediates. The preparation method comprises the following steps: under the conditions of protective atmosphere and illumination, carrying out an addition reaction on 4-benzal-2, 6-di-tert-butylcyclohexane-2, 5-diene-1-ketone and cyclohexane under the action of 4-nitrophthalonitrile, so as to obtain the 2, 6-di-tert-butyl-4-(cyclohexyl (phenyl) methyl) phenol. The preparation method has the advantages of simplicity in operation, mild reaction conditions, low cost of used reagents, high yield and the like, is favorable for realizing large-scale production, provides a key intermediate support for developing low-cost and high-activity anti-staphylococcus aureus drugs, and has important significance in relieving clinical drug-resistant staphylococcus aureus infection treatment dilemma.

The invention provides a tocopherol derivative, preparation method therefor, and uses thereof. The tocopherol derivative is a compound with the following structure. wherein R' is hydrogen or an acetyl group; the theanine and tocopherol are esterified in the presence of a catalyst and a co-catalyst to obtain the tocopherol derivative. The compound can be used as an antioxidant in cosmetics, food and health products, pet products, etc. The method has mild reaction conditions, simple operation, high yield, high synthesis efficiency, economic and environmental protection, and has good application prospects.

The invention provides a tocopherol derivative, preparation method therefor, and uses thereof. The tocopherol derivative is a compound with the following structure.wherein R′ is hydrogen or an acetyl group; the theanine and tocopherol are esterified in the presence of a catalyst and a co-catalyst to obtain the tocopherol derivative. The compound can be used as an antioxidant in cosmetics, food and health products, pet products, etc. The method has mild reaction conditions, simple operation, high yield, high synthesis efficiency, economic and environmental protection, and has good application prospects.