19 results about "Phenol derivative" patented technology

This invention discloses a piperazine substituted phenol derivative and its applications in pharmaceutical chemistry. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum anesthetic effective dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

The application discloses a cannabidiol derivative and application thereof, and belongs to the technical field of medicinal chemistry. The structural general formula of the cannabidiol derivative is shown as formula (I): (I) R1 is selected from one of hydrogen, chlorine, bromine, a hydroxyl group, a cyano group, an acetoxy group, an acryloyloxy group, a benzoyl group, an acetamide group, an acrylamide group, a propiolamide group, an ethyl thiourea group, a 3-chloro-2,2-dimethylpropionyl group, a 2-ethylsulfonamide acetyl group, a 2-ethylsulfonamide-N-(2-amino-2-oxoethyl) acetyl group, a methylsulfonyl group, an ethylsulfonyl group, a vinylsulfonyl group, an alkyne propylsulfonyl group, a phenylsulfonyl group and a styrylsulfonyl group; and R2 is selected from one of C2-C5 alkyl groups. The cannabidiol derivative disclosed by the application has significantly improved anti-neuroinflammatory activity, significantly reduced cytotoxicity, and a generally improved treatment index of more than 10 times, or even more than 260 times, compared with cannabidiol.

Provided is a chiral cannabidiol (CBD) derivative drug, comprising four chiral derivatives, i.e., (7S)-(-)-CIAC001, (7R)-(-)-CIAC001, (7S)-(+)-CIAC001, and (7R)-(+)-CIAC001; and a use of the four chiral derivatives of CBD in the treatment of neuroinflammation and opioid addiction. Also disclosed are anti-neuroinflammation effects and the ability to regulate the activity of pyruvate kinase M2 (PKM2) of CBD analogs.

The invention provides a tocopherol derivative, preparation method therefor, and uses thereof. The tocopherol derivative is a compound with the following structure. wherein R' is hydrogen or an acetyl group; the theanine and tocopherol are esterified in the presence of a catalyst and a co-catalyst to obtain the tocopherol derivative. The compound can be used as an antioxidant in cosmetics, food and health products, pet products, etc. The method has mild reaction conditions, simple operation, high yield, high synthesis efficiency, economic and environmental protection, and has good application prospects.

The invention provides a tocopherol derivative, preparation method therefor, and uses thereof. The tocopherol derivative is a compound with the following structure.wherein R′ is hydrogen or an acetyl group; the theanine and tocopherol are esterified in the presence of a catalyst and a co-catalyst to obtain the tocopherol derivative. The compound can be used as an antioxidant in cosmetics, food and health products, pet products, etc. The method has mild reaction conditions, simple operation, high yield, high synthesis efficiency, economic and environmental protection, and has good application prospects.

The application discloses a kind of composite dryer coating aids and preparation method thereof, specifically related to the field of functional polymer composite coating, it is composed of main agent and auxiliary agent, main agent includes biological base modified epoxy prepolymer and phenolic epoxy resin, auxiliary agent includes surface grafted composite nano functional filler, modified amine curing agent, leveling agent and defoaming agent;Biological base modified epoxy prepolymer is prepared by the reaction of cashew phenol derivative and epichlorohydrin after toughening modification by unsaturated fatty acid;Composite nano functional filler takes nano boron nitride and silicon carbide as core, after bridging by silane coupling agent, grafted with epoxy group containing thorny polymer brush.The application realizes the high monodispersity and chemical anchoring of nano filler by molecular design, and forms interpenetrating network structure with biological base component, and the coating has high thermal conductivity, high wear resistance, excellent anti-sticking and strong adhesion, solves the problem that filler is easy to aggregate and comprehensive performance is difficult to consider, can significantly improve the running efficiency and life of papermaking dryer.

The present invention relates to a personal care composition which delivers even and bright skin tone. This is achieved by including in a topical composition a resorcinol derivative in combination with an oil derived from moringa seed, in a cosmetically acceptable carrier.

The present application relates to a kind of phenol derivatives, and its crystal form and preparation method, especially for the solid-state intermediate for preparing phenol derivative, specifically provide a kind of compound shown in formula (I) or formula (II) and its stereoisomer, crystal form and preparation method.

A pharmaceutical composition of a phenol derivative and use thereof. The pharmaceutical composition comprises the following components: an active ingredient, a thickening agent, an emulsifier, a humectant, a chelating agent, a pH regulator, an oil phase matrix, and water, wherein the active ingredient is selected from at least one of a compound of formula (I) and a pharmaceutically acceptable salt thereof; the active ingredient is dispersed in a homogeneous and uniform emulsion drop form and has good physical and chemical stability. The composition is suitable for the treatment of atopic dermatitis, psoriasis and seborrheic dermatitis, especially for the treatment of atopic dermatitis and seborrheic dermatitis of children, and has good safety, stability, and effectiveness, and uniform morphology characteristics.

A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

This invention relates to the field of nanomaterials technology, specifically to a catechol derivative ligand and its modified gold nanoparticles and their applications. The catechol derivative-modified gold nanoparticles provided by this invention can act as bioreducing agents, specifically by increasing the GSH / GSSG ratio and NADPH / NADP ratio in tumor cells. + By adjusting the ratio, reducing extracellular H2O2 content, increasing GPx content, and decreasing MDA content, a reducing stress state is formed, thus enabling it to act as a biological reducing agent. Under reducing stress, it can not only inhibit the proliferation rate of tumor cells but also activate mitomycin C, enhancing the therapeutic effect of mitomycin C on tumors.

The present invention is directed to compositions for oral administration comprising two or more active ingredients selected from the group consisting of quercetin, metabolites, derivatives and salts and hydrates thereof, a kaempferol rutinoside and salts and hydrates thereof, indole-3-carbinol and derivatives and metabolites and salts and hydrates thereof and gallic acid and salts and hydrates thereof. The present invention is further directed to methods for treating dry eye disease, treating age-related macular degeneration, increasing Bruch's membrane stiffness, modulating expression of a gene selected from the group consisting of YAP, TAZ, integrin α5, integrin β5, interferon β1, interleukin-6, C-X-C motif chemokine ligand 1, C-X-C motif chemokine ligand 10, and combinations thereof, increasing adhesion of retinal pigment epithelium cells to a Bruch's membrane, and methods of modulating a secretory profile of senescent cells exhibiting the senescence-associated secretory phenotype comprising administering an effective amount of one or more active ingredients selected from the group consisting of kaempferol derivatives and salts thereof and hydrates thereof, quercetin metabolites, derivatives and salts and hydrates thereof, indole-3-carbinol and derivatives and metabolites and salts and hydrates thereof and gallic acid and salts and hydrates thereof to a subject in need thereof.

Provided is the use of a mulberry total polyphenol extract in the preparation of a product for promoting bone formation. The active ingredients of the mulberry total polyphenol extract include phenolic acids, polyphenol derivatives, flavones, isoflavones and tannins. The product for promoting bone formation can promote osteoblast proliferation, promote osteogenic calcification, inhibit sclerostin activity, and / or promote bone growth.

This invention discloses the application of acyl-resorcinol derivatives in the preparation of drugs or health products for the prevention and treatment of non-alcoholic steatohepatitis (NASH). Studies have shown that in an in vitro model of free fatty acid-induced normal human hepatocytes, these compounds can exert a hepatoprotective effect by reducing lipid accumulation in cells. The representative compound, hyperacmotone A, significantly reduces lipid accumulation in cells in a dose-dependent manner and regulates the expression of genes such as Pparα, Cpt1, and Fapp1. In a methionine-choline deficiency-induced mouse model, administration of hyperacmotone A can inhibit hepatic steatosis, reduce serum alanine aminotransferase (ALT) and / or aspartate aminotransferase (AST) levels, while simultaneously reducing hepatic triglyceride levels and increasing hepatic glutathione activity. This suggests a certain preventive and therapeutic effect on the occurrence and development of NASH.

This invention provides a method for producing aliphatic aldehydes in high yield by oxidizing aliphatic primary alcohols having four or more carbon atoms. [Solution] A method for producing an aliphatic aldehyde, comprising the step of oxidizing an aliphatic primary alcohol having 4 or more carbon atoms with molecular oxygen in the presence of a phenol derivative and a metal-supported catalyst, wherein the metal-supported catalyst includes a metal supported on an inorganic carrier. A method for producing an aliphatic aldehyde, wherein the phenol derivative is a compound represented by general formula (I). JPEG2026104779000037.jpg27159

A compound of formula (2) or pharmaceutically acceptable salt thereof.wherein R1 is a hydrogen atom or the like; R2 is a methoxy group or the like; R3 is a hydrogen atom or the like; R4 is an optionally substituted C1-6 alkyl group or the like; m is 0, 1, or 2; n is 0, 1, 2, or 3; L1 is —NH—C(═O)—, —C(═O)—NH—, or the like; L2 is a single bond or the like; X is optionally substituted phenyl or the like; Y is optionally substituted phenyl or the like; and X and Y are bonded at a carbon atom on each ring.

The application discloses a kind of organic total synthesis methods of nimesulide derivatives, it is obtained by the reaction of phenol derivative and nitration test, first intermediate;First intermediate and esterification reagent are esterified, and second intermediate is obtained;Second intermediate and nucleophilic reagent are substituted, and third intermediate is obtained;Third intermediate and phenol derivative are coupled, and fourth intermediate is obtained;Fourth intermediate and reducing agent are reduced, and fifth intermediate is obtained;Fifth intermediate and sulfonylation reagent are sulfonylated, and sixth intermediate is obtained;Sixth intermediate and nitration reagent are nitrified, and nimesulide derivative is obtained.The application selects more easily preserved, cheap and easily obtained and higher safety substrate and reagent, process is simple, reaction condition requirement is low, green environmental protection, safety performance is good, product yield is high, easy to scale production.

This application relates to the application of a compound represented by formula I. The compound represented by formula I is as follows: Each R1, R2, and R3 is independently one or more combinations selected from the group consisting of hydrogen, hydroxyl group, halogen, phenyl group, halogenated methoxy group, methylamino group, methyl group, and linear or branched, saturated or unsaturated hydrocarbon groups having 2 to 4 carbon atoms; each R4, R5, R6, and R7 is independently one or more combinations selected from the group consisting of hydrogen, methyl group, and linear or branched, saturated or unsaturated hydrocarbon groups having 2 to 5 carbon atoms; and each m, n, and k is independently an integer from 1 to 3.