449 results about "Phenol derivative" patented technology

The present invention provides phenol derivatives represented by the following general formula or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity or the like, and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof. In the chemical structure, R¹ and R² represent H, OH, NH₂, etc.; R³and R⁴represent H, OH, a halogen atom, an optionally substituted alkyl group, etc.; ring A represents an aryl group or a heteroaryl group; G represents a group represented by the following general formula (G); E¹ represents H or F; and E² represents H, F, or a methyl group, etc.

The invention discloses an alkylphenol modified phenolic amide curing agent and a preparation method thereof. The alkylphenol modified phenolic amide curing agent comprises the raw components including phenol or phenol derivatives, methanal or paraformaldehyde, polyamine and fatty acid or fatty acid polymer. The preparation method comprises the following steps of: uniformly mixing the fatty acid or the fatty acid polymer and the polyamine, heating the mixture, cooling the mixture, adding the phenol or the phenol derivatives in the mixture, uniformly mixing the methanal or the paraformaldehyde with the mixture, heating the new mixture, and performing dehydration on the new mixture to obtain the product; or the preparation method comprises the following steps of: uniformly mixing the phenol or the phenol derivatives, the polyamine and the methanal or the paraformaldehyde, heating the mixture, adding the fatty acid or the fatty acid polymer into the mixture, heating the new mixture, and performing the dehydration on the new mixture to obtain the product. The curing agent disclosed by the invention is very strong in salt spray corrosion resistance, is superior to polyamide curing agent and curing agent products of modified phenolic aldehyde amide resin and mixtures of the modified phenolic aldehyde amide resin, and has good impact strength and flexibility as well as excellent water tolerance.

The objetive of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-alpha-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivative, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

An electrophotographic photoreceptor of the present invention comprises a conductive support and a photosensitive layer. The photosensitive layer on the farthest side from the conductive support, includes a phenol derivative-containing layer which contains a phenol derivative having a methylol group and a charge transport material having at least one selected from the group consisting of a hydroxyl group, a carboxyl group, an alkoxysilyl group, an epoxy group, a thiol group and an amino group. An infrared absorption spectrum of the phenol derivative-containing layer satisfies the conditions represented by the following formula (1):

(P₂/P₁)≦0.2  (1)

P₁ is an absorbance of a maximum absorption peak in a range of 1560 cm⁻¹ to 1640 cm⁻¹, and P₂ is an absorbance of a maximum absorption peak in a range of 1645 cm⁻¹ to 1700 cm⁻¹.

The invention discloses a method for preparing cyclohexanol by catalyzing phenol hydrogenation by taking a porous carbon material loaded base metal as a catalyst. The synthetic route of the traditional two-step method comprises phenol hydrogenation and cyclohexanol dehydrogenation, and the catalysis of phenol hydrogenation in preparing cyclohexanol is mainly completed through metals, namely nanometer noble metal Pd, Ni radical and the like which have higher activated cracked hydrogen molecules. The method is characterized in that cyclohexanol is prepared in the presence of a solvent by using the porous carbon material loaded base metal as the catalyst, taking phenol or a phenol derivative as a raw material and catalyzing hydrogenation; a general formula of the catalyst is aM@CXy, wherein a indicates the weight percentage content of the metals contained in the catalyst, M indicates the base metal, C indicates carbon, X indicates a doped mixed element, and y indicates the weight percentage content of the mixed element. The method disclosed by the invention can be used for reducing the usage cost of the catalyst by recovering the catalyst by adopting a simple filtering method, and can obtain cyclohexanol by directly concentrating filter liquor obtained through filtration.

The invention relates to a recovery method of carbon-fiber reinforced epoxy composites. A method in the prior art has defects of strict reaction requirements and high recovery cost. The method provided in the invention comprises the steps of: cutting composites needing to be decomposed into blocks with volumes smaller than 5 cubic centimeters, placing the blocks in a reflux device filled with acid solution, heating for 5-30 minutes at a boiling temperature, drying in vacuum after washing the composites, placing the dried composites in a sealed reactor, adding materials containing hydroxyl and oxidizing agent into the sealed reactor, heating, then cooling the material to normal temperature to obtain primary products, placing and dipping solid products of the primary products in industrial acetone solution after washing the solid products, recycling to obtain carbon fiber, and carrying out liquid separation, extraction and distillation for liquid products to obtain phenol and phenol derivatives. According to the invention, the recovery is carried out under low temperature and low pressure; the reaction condition is mild; the recovery can be controlled easily; the recovery has few by-products, almost no pollution, and no equipment corrosion. The recovery method is a green recovery way.

The present invention provides methods, enzymes, and cells for the biosynthetic production of phloroglucinol from malonyl-CoA, which is ultimately obtained from simple starting materials such as glucose; also provided are methods for preparing derivatives of biosynthetic phloroglucinol, including, e.g., resorcinol.

The invention relates to a pyrolyzation and debromination method of a waste printed circuit board. A nonmetal substance containing the main components of epoxy resin and glass fiber is separated from the waste print circuit board, a nitrogen-contained compound which is cheap and easy to obtain is used as a catalyst, pyrolyzation and debromination are carried out in three temperature stages through controlling a pyrolyzation temperature raising procedure, so that bromine in a nonmetal separator of the waste printed circuit board is volatilized and removed in a low molecular bromide gas product way (HBr, CH3Br), the formation of dioxin as an objectionable constituent is effectively avoided, and meanwhile, a liquid product taking phenol derivatives (phenyl hydroxide, australol) as the main components is obtained, and finally, the effective utilization ratio of the nonmetal material in the waste printed circuit board is improved. The invention has the advantages of simple method, easy obtaining of raw materials, no environment pollution, and the like, and can be widely applied to the recycling of the waste printed circuit board.

The invention belongs to the field of pharmaceutic preparations, and relates to a targeted ligand-PEG (polyethylene glycol)-cholesterol/tocopherol derivative, and a preparation method and an application of the derivative, in particular to an application of the derivative in a composite mechanism mediate tumor targeted drug delivery system. According to the derivative, the preparation method and the application, a drug delivery system consisting of the targeted ligand-PEG-cholesterol/tocopherol derivative with a targeting function, a long circulating function and a pH (power of hydrogen) sensitive function as a functional material, a cation liposome and a drug can simultaneously carry anticancer polypeptide and gene/chemotherapy drugs. According to the system, different drugs are jointly entrapped into the lipid nano drug delivery system and delivered into a targeted cell by utilizing a physicochemical property difference between components or by in-vivo specific targeted recognition, signal conduction blocking and pH triggering PEG chain breaking charge reversion methods, so that a targeted tumor therapeutic effect is improved. According to the derivative, the preparation method and the application, the advantages of the system in directional delivery, co-delivery and the like are proved by in-vivo and in-vitro activity evaluation, the anticancer activity is improved significantly, and definite synergic therapeutic and immunity effects are provided.

An oil-based demulsifying formulation which can be used in the treatment of drains bored in oil-based mud, non ecotoxic and optimally compatible with formation fluids, comprises at least one wetting agent selected from the group consisting of anionic surfactants and at least one demulsifier (or "emulsion breaker") selected from the group consisting of copolymers of ethylene oxide and propylene oxide, alcohol or phenol derivatives with alkoxylated or polyalkoxylated chain formations, polyalkyleneglycols, polyamines, alkoxylated or polyalkoxylated derivatives of amines, quaternary ammonium salts, quaternized alkanolamine esters, alkyl esters of fatty acids or natural oils, possibly alkoxylated or polyalkoxylated, and silicated derivatives such as polysiloxanes.

A color conversion composition converting incident light to light having a longer wavelength than the incident light, and containing the following components (A)-(C): (A) at least one luminescent material; (B) a binder resin; and (C) at least one of tertiary amines, catechol derivatives and nickel compounds, in which the tertiary amines, the catechol derivatives and the nickel compounds have a molar extinction coefficient ε of 100 or less over the whole wavelength range from 400 nm to 800 nm is provided. This color conversion composition achieves a good balance between improvement of color reproducibility and durability if used for a liquid crystal display or an LED lighting device.

An environmentally-safe method for protecting plants is provided for reducing the use of chemically-synthesized pesticide. Specifically, an anti-microbial and/or anti-viral composition comprising a laccase, a cell of a laccase-producing microorganism or a treated product thereof, and one or more kinds of phenol derivatives each represented by the general formula (I) shown below or a salt of the phenol derivative is provided. Furthermore, a plant disease-preventing agent, seed-sterilizing agent, post-harvest agent, and nutrient solution-sterilizing agent, each containing the composition; and plant disease-preventing method, seed-sterilizing method, post-harvest-treatment method, and nutrient solution-sterilizing method in hydroponics and solid-medium hydroponics using each f the agents are provided.

(in this formula, each of R₁ to R₅ independently represents hydrogen, an alkyl group having 1 to 6 carbon atoms, substituted or unsubstituted alkenyl group having 2 to 6 carbon atoms, alkoxy group having 1 to 6 carbon atoms, substituted or unsubstituted aryl group having 6 to 20 core carbon atoms, carboxyl group having 1 to 10 carbon atoms, carbonyl group having 1 to 10 carbon atoms, or halogen atom, and at least one of R₁ to R₅ is an alkenyl group having 1 to 10 carbon atoms; provided that at least one of R₁ and R₅ is not an alkoxy group).

The invention discloses a new typed fluorescent probe and synthesizing method and application to detect hyperoxygen anion free radical in the cell selectively, which comprises the following steps: dissolving aromatic o-aminophenyl-sulfhydrate or aromatic o-aminophenyl-sulfhydrate derivant with weight rate at 1:2 -3.5 into composite solution with butanol and benzene with bulk rate at 1:0.3-0.6; heating the composite liquid to reflux 3-5h; decompressing to remove solvent; obtaining rough product; recrystallizing through alcohol; drying in the vacuum; obtaining pure product.

The invention relates to a novel benzothiophene derivative and application thereof in preventive and/or treatment medicine for breast cancer and osteoporosis. The benzothiophene derivative is an ideal selective estrogen receptor modulator, can be used for treating or preventing various indications related to estrogen functions, and is particularly applicable to treating post-menopause breast cancer and osteoporosis. The compound has the advantages that oxidative metabolism is lowered, effective bioavailability is higher, and accordingly, dosage of the compound is little, tolerance of the compound is fine, and side effects are low.

The present invention relates to an aqueous formulation containing phenol and/or phenol derivatives having a low freezing point and anti-microbial activity.

A resin composition for laser engraving, including at least a phenol derivative (A) represented by the following Formula (A), a binder polymer (B), and a crosslinking agent (C), wherein the content of the phenol derivative (A) with respect to the total solid content of the resin composition is from 5% by mass to 50% by mass:

The invention discloses a catalytic preparation method for hindered phenol derivative antioxygen. In the invention, a catalytic dehydration process is adopted to prepare the hindered phenol derivative antioxygen, the reaction raw materials are subjected to acidification and monohydrazidation respectively to form two intermediates, and thionyl chloride is not used so as to reduce pollution; and then a solvent and two intermediates are added into a reactor and heated and refluxed to undergo dehydration in the presence of a catalyst, and water is separated out by a water segregator. In the invention, due to the adoption of the catalyst, the reaction temperature is lower, the raw material utilization rate is high, the reaction time is short, and the product yield is high; therefore, the method can contribute to the reduction of production cost and is suitable for industrial production. Evaluation on the use of the antioxygen in polyolefin wire and cables shows that the antioxygen prepared by the method disclosed by the invention has high antioxygen performance and metal passivating capacity.

A negative resist composition comprising: (A) a compound being capable of generating an acid upon irradiation with an actinic ray or a radiation; (B) an alkali-soluble polymer; and (C) at least two crosslinking agents being capable of generating crosslinking with the polymer (B) by an action of an acid, wherein the crosslinking agent (C) comprises at least two compounds having a different skeleton from each other, which are selected from phenol derivatives having at least one of a hydroxymethyl group and an alkoxymethyl group on a benzene ring thereof, in which a sum of the hydroxymethyl group and the alkoxymethyl group is two or more, one of the at least two crosslinking agents comprises one or two benzene rings in the molecule thereof, and other one of the at least two crosslinking agents comprises from 3 to 5 benzene rings in the molecule thereof.

The invention relates to a low-temperature aqueous-phase catalyst for lignin phenol derivative hydrodeoxygenation and a preparation method thereof. The catalyst comprises a zeolite molecular sieve HBeta serving as a carrier and a load Ru, wherein the molar ratio of silicon to aluminum is 10-50, and the loading amount of Ru is 0.1 to 2%. The preparation method comprises the following steps: mixing measured aqueous solution of RuCl3 with a zeolite suspension, evaporating water and drying, and then reducing the obtained solid with hydrogen/argon mixed gas. A cyclic hydrocarbon (the conversion rate is greater than 98% and the selectivity is greater than 95%) is prepared at high selectivity under the relatively mild (100-150 DEG C and 1-4MPa) condition, so that the defects that the reaction conditions are harsh and the energy efficiency is low in the refining process of biomass pyrolysis oil can be overcome. The bifunctional catalyst provided by the invention has the advantages of simplicity and easiness in operation in the preparation process, stable physical and chemical properties, and direct application. At low temperatures, the catalyst shows excellent hydrodeoxygenation activity and extremely high selectivity of saturated hydrocarbons, has a simple and environment-friendly reaction process, and can be widely used in the refining of bio-gasoline.