203 results about "Phenol derivative" patented technology

The invention discloses a deep-eutectic solvent for oil-containing solid waste treatment, an inorganic base and CO2 double-circulation oil-solid separation method based on the deep-eutectic solvent and the deep-eutectic solvent for oil-containing solid waste treatment. The deep-eutectic solvent for oil-containing solid waste treatment is characterized in that branched or cyclic short-chain fatty acid with pKa being 4-6 is used as a hydrogen bond donor; a phenol derivative with pKa being 9-11 or C6-C8 straight-chain alcohol is used as a hydrogen bond acceptor; the ratio of the hydrogen bond donor to the hydrogen bond acceptor is (5: 1)-(1: 5) according to the molar ratio of the hydrogen bond donor to the hydrogen bond acceptor; the regulation and control method based on the deep-eutectic solvent comprises the following steps: (1) reacting inorganic alkali with the deep-eutectic solvent to form a hydrophilic carboxylate and phenate solution; (2) after CO2 is introduced, fatty acid / phenols are collected to form a hydrophobic deep-eutectic solvent again, and meanwhile, a bicarbonate aqueous solution is obtained; and (3) heating the bicarbonate aqueous solution or introducing N2, removing CO2, and forming hydrophilic carboxylate and phenolate again by the eutectic solvent in the formed alkaline carbonate solution. According to the inorganic base and CO2 double-circulation oil-solid separation method based on the eutectic solvent, the eutectic solvent can be recycled.

A substituted phenol derivative and the use thereof, which relates to the field of medicinal chemistry. The substituted phenol derivative is a compound represented by formula I, or a stereoisomer, a pharmaceutically acceptable salt, a solvate, a prodrug, a metabolite, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and / or anesthetic effects, but also has an analgesic effect. The derivative can control status epilepticus, and has good safety during use. Therefore, the derivative has broad application prospects in the preparation of a drug having both sedative, hypnotic and / or anesthetic effects and an analgesic effect and capable of controlling status epilepticus, and provides a new option for the clinical preparation of a drug having both an analgesic effect and sedative, hypnotic and / or anesthetic effects, which is capable of controlling status epilepticus, etc.

The invention discloses a glucosyltransferase and a preparation method and application of a mutant of the glucosyltransferase. The amino acid sequence of the glucosyltransferase comprises a sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2. The glucosyltransferase and the mutant thereof can efficiently catalyze the generation of the tocopherol glucoside, the enzyme activity can reach 0.34 U / mg, a new way of synthesizing the tocopherol glucoside by a biological method is developed, the glucosyltransferase and the mutant thereof can be widely applied to the fields of medicines, cosmetics and the like, the industrial production of tocopherol derivatives is promoted, and the production cost is reduced. The requirements of the market on high bioavailability and high stability tocopherol derivatives are met, and the technical progress and industrial upgrading of related industries are promoted.

The present invention provides a fiber structure having excellent antibacterial properties and washing durability, and a method for producing the same. [Solution] A textile structure having polyamide fibers and containing a dye, a quinoline-based compound, and a phenol derivative, wherein the textile structure contains 0.04% by mass or more of the quinoline-based compound relative to the mass of the textile structure, and even after 10 standard washes in accordance with the "SEK Mark Textile Product Washing Method," the textile structure contains 0.04% by mass or more of the quinoline-based compound relative to the mass of the textile structure, and 0.20% by mass or more and 4.00% by mass or less of the phenol derivative relative to the mass of the textile structure.

The invention relates to application of a vitamin E compound in preparation of a MACIR protein targeting agent. The vitamin E compound comprises any one or a combination of at least two of tocopherol, tocopherol derivatives, tocotrienol or tocotrienol derivatives. The invention creatively discovers the interaction between tocopherol, tocopherol derivatives, tocotrienol or tocotrienol derivatives and MACIR protein, and proves the strong binding capacity of tocopherol or derivatives thereof and MACIR protein through experiments. The tocopherol, the tocopherol derivative, the tocotrienol or the tocotrienol derivative can be used for regulating the function of MACIR protein associated immune cells so as to influence the expression of inflammatory factors, play an important role in inflammation and anaphylaxis, and also can be used for improving skin injury repair.

The invention belongs to the technical field of cosmetics, and discloses a composition for relieving redness and inflammatory color deposition as well as a preparation method and application of the composition. The composition comprises the following components: a plant extract and a derivative thereof, zinc salt, a resorcinol derivative and protein, the plant extract and the derivative thereof comprise at least one of an artemisia apiacea extract and a derivative thereof, and a glycyrrhiza inflate extract. The artemisia apiacea extract and the derivative thereof and / or the glycyrrhiza inflate extract, the zinc salt, the resorcinol derivative and the protein are reasonably compounded, so that red, swollen and discomfort in the inflammation period can be relieved, repair of damaged skin can be promoted, color sink after inflammation can be reduced, and scar generation can be inhibited; meanwhile, the composition is mild and non-irritant, and is suitable for sensitive skin and damaged skin.

The present invention is directed to a composition including a Tryptophol derivative, a 4-Ethyl-Phenol derivative, or a combination thereof, and a method of using same, such as for treating a subject in need of modulation of blood coagulation.

The invention relates to a method for extracting two tocopherol derivatives A and B from epimedium sagittatum and application of the two tocopherol derivatives A and B, which can effectively solve the problem of preparing the tocopherol derivatives A and B from the epimedium sagittatum and realizing the application of the tocopherol derivatives A and B in preparing anti-breast tumor drugs, and the method comprises the following steps: crushing the overground part of the epimedium sagittatum, carrying out reflux extraction with ethanol, carrying out reduced pressure recovery to obtain an extract, extracting, and carrying out chromatographic separation to obtain the two tocopherol derivatives A and B; and carrying out gradient elution, reduced-pressure recovery, thin-layer point plate detection, merging, purification, collection of fractions within retention time, and drying to obtain the product. The raw materials are rich, the preparation method is easy to operate, the obtained product is good in quality and good in use effect, the pharmaceutical composition can be effectively used for treating breast cancer, application in preparation of anti-breast cancer drugs is achieved, the medicinal value and commercial value of epimedium sagittatum are developed, and the pharmaceutical composition has remarkable economic and social benefits.

The invention discloses a novel photochromic dye and a preparation method thereof, and belongs to the technical field of fine chemical synthesis and optical functional materials. The invention prepares a novel photochromic dye by reacting a diaryl ketone with (propynyloxy) trimethylsilane to generate a hydroxyl-functionalized diaryl alkynol, and reacting the diaryl ketone with succinate and acetic anhydride to generate a naphthol derivative, and reacting the naphthol derivative with the above-mentioned hydroxyl-functionalized diaryl alkynol to generate a cyclic lactone-modified naphthopyran compound. The photochromic dye has a fast discoloration speed, can be used in the fields of color-changing lenses, textiles, anti-counterfeiting, coatings, etc., and the preparation process is simple and easy to operate.

The invention discloses substituted phenol derivatives and application thereof, and relates to the field of medicinal chemistry. The substituted phenol derivative is a compound as shown in a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, or a deuterated derivative thereof. The derivative not only has sedative, hypnotic and / or anesthetic effects, but also has an analgesic effect, can control the state of epilepsy, and is good in safety during use. Therefore, the derivative has wide application prospects in preparation of drugs which have sedative, hypnotic and / or anesthetic effects and analgesic effects and can control the epileptic status. The invention provides a new choice for clinically preparing medicines which have the effects of easing pain, calming, hypnotizing and / or anesthetizing, controlling the epileptic status and the like. # imgabs0 #

The invention relates to the field of pipes, and discloses a high-strength CPVC pipe and a preparation method thereof.The pipe comprises CPVC resin, modified multi-walled carbon nanotubes, modified nano silicon dioxide and auxiliaries; the modified multi-walled carbon nanotubes are prepared by grafting phosphorus-containing cardanol derivative based benzoxazine and oxidized multi-walled carbon nanotubes; phosphorus-containing cardanol derivative benzoxazine reacts with 1, 5-naphthylenediamine to prepare an aldehyde cardanol intermediate, the aldehyde cardanol intermediate is prepared by reacting paraformaldehyde with hydrogenated cardanol, the obtained cardanol derivative and DOPO are subjected to addition, and then the obtained phosphorus-containing cardanol derivative reacts with paraformaldehyde and 3-aminopropyltriethoxysilane to prepare the flame retardant. The modified nano silicon dioxide is prepared by introducing polyethylene glycol into the surface of isocyanated nano silicon dioxide and grafting with 3, 5-bis (tert-butyl)-4-hydroxybenzene propionyl chloride, and the pipe prepared by the invention is high in tensile strength and impact strength and has good long-acting oxidation resistance, high temperature resistance and flame retardance.

The purpose of the present disclosure is to provide: a photochromic compound having excellent temperature dependency and an excellent color fading rate; a phenol derivative that can be an intermediate for the photochromic compound; and a curable composition, an optical article, a lens, and an eyeglass, each containing the photochromic compound. An embodiment of the present invention provides a photochromic compound having a backbone represented by formula (1). In formula (1), M represents C, Si, or Ge. Ring A is a substituted or unsubstituted aromatic ring, a substituted or unsubstituted aromatic heterocyclic ring, or a substituted or unsubstituted condensed polycyclic ring obtained through fusing, to either of said rings, an aromatic ring or an aromatic heterocyclic ring. Z1 represents a group represented by formula (1a) or a group represented by formula (1b).

This invention provides a novel GABA structure with better efficacy, reduced side effects, and greater safety for clinical use. A This invention relates to receptor agonists, specifically a phenol derivative, its preparation method, and its use in the central nervous system. The phenol derivative provided by this invention offers more and better drug options for inducing or maintaining anesthesia in animals or humans, promoting sedation and hypnosis, and treating and / or preventing anxiety, nausea, vomiting, migraines, seizures, epilepsy, neurodegenerative diseases, and other central nervous system-related disorders.

The invention provides a thymol derivative as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The preparation method comprises the following steps: carrying out esterification reaction on thymol and indole-3-carboxylic acid to prepare a thymol derivative, namely 2-isopropyl-5-methyl phenyl 1H-indole-3-carboxylic ester. Under the process conditions provided by the invention, the yield of the thymol derivative can reach 93-94%. The anti-coccidiosis index of the thymol derivative is as high as 196.51, and the thymol derivative can obviously reduce the influence of chicken coccidiosis on the weight of chicken, has a remarkable effect of promoting the growth and development of the body, and can obviously improve the clinical symptoms of chicken infected with coccidiosis, recover the mental condition and appetite of sick chicken, obviously reduce the occurrence of bloody stool and improve the intestinal tract lesion condition; the anti-coccidiosis effect of the thymol derivative provided by the invention is obvious and is obviously better than that of thymol, and the thymol derivative is expected to become a new veterinary drug for treating chicken coccidiosis infection.

The invention belongs to the technical field of new energy materials, and particularly relates to a high-stability neutral aqueous flow battery based on a quaternary ammonium salinized biphenol derivative. The preparation method comprises the following steps: bridging biphenol and dimethylamine through a condensation reaction to obtain an intermediate, and further introducing a water-soluble quaternary ammonium salt group to obtain the quaternary ammonium salinized biphenol derivative. The solubility of the material in pure water is as high as 6.28 M, and the material has the advantages of high potential, good redox reversibility and fast reaction kinetics. The neutral aqueous flow battery with high stability and energy efficiency is obtained after assembling by taking the neutral aqueous flow battery as a catholyte, methyl viologen as an anolyte and a sodium chloride aqueous solution as an electrolyte. The discharge platform of the redox flow battery is 1.06 V, the discharge capacity is 12.86 mAh, after cyclic charge and discharge, the capacity fading rate of each circle is 0.02%, the coulombic efficiency is 98.49%, the energy efficiency reaches 90.21%, and the application prospect is wide.

The invention discloses a pharmaceutical composition containing a substituted indole-5-phenol derivative and an application of the pharmaceutical composition. Specifically, the present invention discloses a first pharmaceutical composition comprising a substituted indole-5-phenol derivative, the first pharmaceutical composition comprising (a) a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof; and (b) one or more of 1, 2, 3, 4 or 5 high polymer materials. # imgabs0 #

The invention discloses a synthesis method of Peniterpheyl A. According to synthesis of a key structural unit furan ring, diphenyl ether is synthesized through a simple heating substitution reaction of a phenol derivative and a fluorobenzene derivative, then C-C direct oxidative coupling of double benzene rings in a molecule is achieved under a Pd / Ag catalytic system to synthesize the furan ring, and due to steric hindrance and guiding group effects, the furan ring can be synthesized into the furan ring. The product has high selectivity, does not need harsh reaction conditions, has simple synthesis steps, is suitable for large-scale production, does not need to widely screen specific strains and fermentation conditions compared with a method for obtaining a low-amount target compound from microbial fermentation separation, is simple and efficient, and can guarantee a large amount of compounds required by subsequent research and development.

The application discloses a porphyrin-eugenol derivative with antitumor activity, uses DPBF to detect the yield of singlet oxygen, and in-vitro antitumor activity test shows that the compound has good activity. The porphyrin-coumarin compound can realize the synergistic treatment of phototherapy and chemotherapy, in addition, the insertion of metal Zn in the porphyrin can also enhance the antitumor activity of the compound. Thus, the compound can be used as an active ingredient of an antitumor drug, and has good development and application prospect.

This invention discloses a piperazine substituted phenol derivative and its applications in pharmaceutical chemistry. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum anesthetic effective dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and / or anesthetic effects, as well as in drugs for controlling status epilepticus.

The invention relates to a preparation process of an anti-wrinkle breathable fabric, and belongs to the technical field of breathable fabrics. The preparation technology of the anti-wrinkle breathable fabric comprises the following steps that S1, 50 wt% polyester and 50 wt% cotton blended yarn serves as warp yarn, winding is conducted through a warping machine, and a blended fabric is obtained; s2, the blended fabric is soaked in an alkaline solution, filtering, washing and vacuum drying are conducted, and a pretreated fabric is obtained; s3, the pretreated fabric is placed in a chitosan solution for ultrasonic treatment and then soaked, and a mixture is obtained; and S4, adding a cardanol derivative into the mixture, stirring, carrying out heat preservation treatment, centrifuging, washing, and carrying out low-temperature drying, thereby obtaining the product. The blended fabric is soaked in the alkaline solution, adhesion of chitosan is promoted, aldehyde groups are introduced into the cardanol derivatives, imine bond connection with a self-repairing function can be formed through the aldehyde groups and free amino groups, organic coating is formed on the blended fabric, and the blended fabric is endowed with a better crease-resistant effect.

The application discloses a kind of polysubstituted phenol derivatives and electrochemical preparation method thereof, which uses 2-(benzo[d]thiazole-2-yl)-4-substituted phenol, substituted pyrazole or benzimidazole as raw material, tetrabutylammonium tetrafluoroborate as electrolyte, a mixture of hexafluoroisopropanol and dichloromethane (volume ratio 7:3) as solvent, direct electrolysis reaction under air atmosphere at room temperature to obtain the target product shown in formula one or formula two. Research has found that such products have good solid fluorescence and exhibit aggregation-induced emission properties in tetrahydrofuran and water systems. The method of the application has the advantages of simple operation, good compatibility of substrate functional groups, mild conditions, low production process cost and environmental friendliness.

The invention discloses a (-)-gossypol derivative, a preparation method thereof and an antioxidant, and relates to the technical field of chemical synthesis, the (-)-gossypol derivative comprises a (-)-gossypol-polylysine derivative and / or a pharmaceutically acceptable salt thereof, the repetitive structural unit of the (-)-gossypol-polylysine derivative comprises any one of a structural formula (I) and a structural formula (II); wherein n is equal to 25 to 40. In the novel compound synthesized by the invention, an aldehyde group in the (-)-gossypol and an amino group in the polylysine form a Schiff base compound through an imine bond, an active aldehyde group in the (-)-gossypol is closed, and meanwhile, the (-)-gossypol-polylysine derivative has relatively strong antioxidant activity and is a relatively good antioxidant and drug source.

The object of the invention is a nitroxyl polyphenol derivative of formula:wherein Q is a group derived from a polyphenol;L is an ester linking group containing 1 to 3 carbon atoms;A is a 5- or 6-membered heterocyclic group containing one nitrogen atom which is in the form of nitroxyl radical (NO·), in which both carbon atoms adjacent to the nitroxyl radical are substituted independently of each other with one or two C1-C3 alkyl groups; andn is an integer of 1 to 5.The object of the invention is also methods for the preparation of the above-defined derivative and a use thereof as an antioxidant agent, in particular an antiaging agent.

The invention belongs to the technical field of chemical medicines, and particularly relates to a crystal form of a salt of a propofol derivative as well as a preparation method and application thereof. The invention provides a crystal form of a compound A or a hydrate, an organic solvate or an organic solvate of the hydrate of the compound A with a structure shown as a formula I. The stability and the safety of the crystal form are greatly improved, and the crystal form has important significance for improving the medicine quality. # imgabs0 #

The invention relates to the technical field of analysis and detection, and discloses a method for detecting the content of nonyl phenol in a sealant, and the method comprises the following steps: carrying out derivatization treatment I on a sealant to-be-detected sample with the mass of m g, and diluting to a constant volume I to V ml to obtain a mixed solution; performing chromatographic analysis I on the mixed solution to obtain a peak area Ai of a chromatographic peak of the nonyl phenol derivative; the chromatographic analysis adopts a programmed heating mode, and the programmed heating mode comprises the following steps: preserving heat at the temperature T1 for 0.5-1.5 minutes, then heating to the temperature T2 at the rate of 20-40 DEG C / min, and preserving heat at the temperature T2 for 3-6 minutes; and calculating the mass content X of nonyl phenol in the to-be-detected sample of the sealant according to the following formula: X = (Ai-b) / k * V * F / m * 100%, wherein k is greater than or equal to 90.0 and less than or equal to 110.0; 500 < = b < = 1500. The method provided by the invention is low in cost, high in accuracy, excellent in recovery rate and high in sensitivity.

The purpose of the present invention is to provide: a photochromic compound having excellent temperature dependence and fading speed; a phenol derivative that can be used as an intermediate of the photochromic compound; a curable composition containing the photochromic compound; an optical article; according to one embodiment, a photochromic compound having a skeleton represented by formula (1) is provided. In formula (1), M is C, Si, or Ge. Ring A is a substituted or unsubstituted aromatic ring, a substituted or unsubstituted aromatic heterocyclic ring, or a substituted or unsubstituted fused polyring in which an aromatic ring or an aromatic heterocyclic ring is fused to these rings. Z1 represents a group represented by formula (1a) or a group represented by formula (1b).

The invention provides a resorcinol derivative phospholipid complex dispersion as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. A resorcinol derivative, an antioxidant, lecithin, sodium surfactin and water are used as raw materials, a strongly hydrophobic phospholipid compound is formed through interaction between hydrophilic ends of the lecithin and strong molecules of phenolic hydroxyl groups of the resorcinol derivative, then a hydrophilic cyclopeptide layer is modified on the surface of the phospholipid compound through the sodium surfactin surfactin, and the hydrophobic phospholipid compound is prepared. The dispersity of the phospholipid complex in water is improved, the stability of the resorcinol derivative can be effectively improved, and the problem of high-temperature discoloration is avoided. The particle size of the resorcinol derivative phospholipid complex dispersion provided by the invention is less than 200nm, and the resorcinol derivative phospholipid complex dispersion has good hydrophilicity and better transdermal permeation absorption effect.

The invention aims to provide a nitroxyl polyphenol derivative. The chemical formula of the nitroxyl polyphenol derivative is Q-(L-A) n, wherein Q is a group derived from polyphenol; l is an ester linking group containing 1 to 3 carbon atoms; a is a 5-or 6-membered heterocyclic group containing a nitrogen atom in the form of a nitroxyl radical (NO *) in which the two carbon atoms adjacent to the nitroxyl radical are substituted independently of each other by one or two C1-C3 alkyl groups; and n is an integer from 1 to 5. The invention also relates to a method for producing said derivatives and to the use thereof as antioxidants, in particular anti-aging agents.

The invention discloses a 2-styryl phenol derivative and a hypoglycemic effect thereof, and belongs to the technical field of medicine preparation. According to the present invention, the early stage research results show that the salvianolic acid A has strong alpha-glucosidase inhibition effect; a series of styryl derivatives with novel structures are designed and synthesized by taking a 1, 2-diarylethene structure in a salvianolic acid A structure as a target, and alpha-glucosidase and PTP1B inhibitory activity of various derivatives are deeply studied. The 2-styryl phenol derivative with alpha-glucosidase and PTP1B double-target inhibitory activity is obtained, and a material basis is provided for prevention and treatment of T2DM and complications thereof.

The invention discloses an application of an improved isoluminol luminescent substrate in a MaglumiX8 chemiluminescence immunoassay system, and belongs to the technical field of in vitro diagnostic reagents. The luminescent substrate comprises an alkaline solution containing a metal leaf line complex and a derivative thereof, and a piperazine phenol derivative, and a peroxide solution containing urea and stannate. According to the invention, a metal leaf line substance is added into an alkaline solution, an active structure is stabilized through coordination modification, a reaction with hydrogen peroxide is promoted, a chemiluminescence signal is enhanced, and the luminous efficiency and the detection sensitivity are improved; by adding the piperazine phenol derivative, lasting glow of isoluminol is realized, signal stability is ensured, and result reliability is improved. In a hydrogen peroxide system, a urea / stannate stabilizer is added, so that the stability of a substrate is improved. Experimental verification shows that the substrate has high accuracy correlation with an original reagent, excellent precision and stable performance after being stored at room temperature for 24 months, and is suitable for the detection fields of hormones, tumor markers and the like.