44results about How to "Broad use prospects" patented technology

The invention provides o-mercapto phenol derivatives and a preparation method thereof. The preparation method comprises the following steps: a, synthesizing a precursor; b, synthesizing a target product; and c, purifying. Compared with the prior art, the invention provides a brand new synthetic method of poly-substituted o-mercapto phenol for generating a series of novel o-mercapto phenol derivatives. Compared with common o-mercapto phenol derivatives, the o-mercapto phenol derivatives prepared by the method provided by the invention have multiple rings, so that the o-mercapto phenol derivatives are more complex and diverse in structure and further show a broader application prospect in chemical industry production and clinical medicines.

The invention relates to a benzoin oxime derivative and a preparation method thereof. A structural formula of the benzoin oxime derivative is shown in the specification. The preparation method comprises the following steps: reacting malonate with propargyl bromide in anhydrous acetonitrile under the catalysis of sodium hydride to obtain a white solid product; by taking triethylamine as alkali, reacting the white solid product with phenylethynyl bromine or substituted phenylethynyl bromine in anhydrous acetonitrile under the catalysis of Pd(PPh3)2Cl2 / CuI to obtain a light brown solid product; reacting the light brown solid product with benzoin oxime in toluene at 95-105 DEG C to obtain the benzoin oxime derivative. A brand new synthetic method of polysubstituted benzoin oxime is provided, and a series of new benzoin oxime derivatives are generated. Compared with normal benzoin oxime derivatives, the benzoin oxime derivative prepared by virtue of the preparation method has relatively complex and diverse structures by virtue of multiple cycles, and presents relatively wide application prospects in chemical industry production and clinic medicines.

The present invention provides salicylaldehyde derivatives and a preparation method thereof. The preparation method comprises: a, precursor synthesis; b, target product synthesis; and c, purification. Compared with the salicylaldehyde derivative and the preparation method thereof in the prior art, the salicylaldehyde derivative and the preparation method thereof of the present invention have the following characteristics that: the completely-new poly-substituted salicylaldehyde derivative synthesis method is provided, a series of the new salicylaldehyde derivatives are produced, and compared with the ordinary salicylaldehyde derivative, the prepared salicylaldehyde derivative of the present invention has multiple rings so as to have the complex and diverse structure, and presents wide application prospects in chemical engineering production and clinical medicine.

The invention discloses a diphenyl telluride derivative and a preparation method thereof. Compared with the prior art, a series of novel diphenyl telluride derivatives are provided. Compared with ordinary diphenyl telluride derivatives, the prepared diphenyl telluride derivative has multiple rings, the structure is more complicated and diversified, the diphenyl telluride derivative has wider application prospect in chemical industry production and clinical medicines, the provided preparation method is simple and efficient, the reaction time is short, and the efficiency is high.

The invention discloses a benzofuran derivative and a preparation method thereof. A benzofuran compound is prepared from different multi-alkyne substrates by a cascade reaction. The reaction overcomes the defects of excessively long path, harsh substrate and reaction condition requirements, limited expansion of substituted functional groups and the like in a conventional reaction; the reaction not only is simple in substrate synthesis and relatively low in price of reagents, but also has high atom economy, obtains target molecules in a green and environmental-friendly manner, and provides a valuable approach for industrial production of benzofuran.

The invention provides a chimeric antigen receptor (CAR) polypeptide for pathogens. The chimeric antigen receptor polypeptide is provided with: (a) an extracellular domain comprising one or more antigen binding regions having pathogen-related antigen specificity; (b) a transmembrane domain; and (c) one or more copies of an intracellular signal domain of a 'eat-me' signal receptor, which can be specifically bound to a pathogen antigen and activate an endogenous silence type phagocytic clearance signal. Further, the invention also provides polynucleotides encoding the polypeptide, gene vectors,recombinant cells carrying chimeric antigen receptors, and a composition. The chimeric antigen receptor characteristically mediates recombinant cells to perform phagocytic clearance on the pathogens,and does not significantly release cytokines, so that a 'silence' type pathogen clearing mode is actually realized.

The invention discloses a multi-purpose gathering combustion type rotary furnace. The multi-purpose gathering combustion type rotary furnace comprises a furnace base. An outer furnace barrel and an inner furnace barrel are installed on the furnace base in a rotating mode and are synchronous. The two ends of the outer furnace barrel are connected with a feeding and discharging end base and a gathering combustion end base in a dynamic sealing mode correspondingly. One end of the inner furnace barrel is connected with a sealed feeding device. A combustion isolation body which stretches into the inner furnace barrel is arranged on the gathering combustion end base, a gathering combustion channel is formed in the portion, corresponding to a material gathering region, of the combustion isolationbody, and a slag falling opening is formed in the gathering combustion end base. A combustion supporting air supply pipe is arranged in the gathering combustion channel, and an annular flame retardant layer is arranged in the inner furnace barrel. A gas resistance device is arranged between the gathering combustion end base and the portion, located outside the material gathering region, of the inner furnace barrel, and the inner furnace barrel is connected with a gas supplement device. According to the multi-purpose gathering combustion type rotary furnace, the combustion heat can preheat rawmaterials, organic matter components can be precipitated and subjected to thermal decomposition to be gasified, the air flow enables the gaseous combustible materials to arrive at the gathering combustion channel and to be gathered, the centralized and powerful combustion is easily formed, and therefore the residual combustible materials inside the raw materials can be prompted to be sufficientlyburnt, and the number of hazardous substances in the tail gas can also be obviously reduced.

The invention discloses a benzodihydropyran ring derivative and a preparation method thereof. The malonate and propargyl bromide are used as initial raw materials to synthesize a benzodihydropyran ring derivative through a three-step reaction; and the raw material is simple and easy to obtain, the synthesis method is convenient and fast, and an efficient and fast synthesis path is provided for the preparation of the benzodihydropyran ring derivative.

The invention provides poly-substituted 3-phenyl phenol derivatives and a preparation method thereof. Compared with the prior art, a series of novel poly-substituted 3-phenyl phenol derivatives is provided. Compared with common poly-substituted 3-phenyl phenol derivatives, the prepared poly-substituted 3-phenyl phenol derivatives have a multi-ring structure, the structure is more complicated, and thus the provided derivatives have a wide application in industries such as chemical engineering, clinical medicine, materials, and the like. Furthermore, the provided preparation method has the advantages of simpleness, high efficiency, and short reaction time.

The invention provides a ferrocene derivative and a preparation method thereof. Compared with the prior art, in the absence of catalyst and additive as well as protection and with toluene as a solvent, a tetra-alkyne substrate reacts with ferrocene at 104-114 DEG C, wherein the reaction process comprises the following steps: cyclization of the tetra-alkyne substrate, generation of a benzyne intermediate through a HDDA reaction, and 4+2 cycloaddition reaction between the highly active benzyne intermediate and the cyclopentadiene of ferrocene to obtain the ferrocene derivative. The method breaksthrough the former knowledge that the ferrocene cannot experience a cycloaddition reaction, and also shows a broader application prospect in chemical production and clinical medicine. Moreover, the preparation method provided by the invention has the advantages of simplicity and convenience, high efficiency and short reaction time.

The invention discloses an o-hydroxyaniline derivative and a preparation method thereof. Compared with the prior art, the invention provides a synthetic method of an o-hydroxyaniline derivative to generate a series of novel o-hydroxyaniline derivatives. Compared with existing o-hydroxyaniline derivatives, the o-hydroxyaniline derivative prepared by the invention is polycyclic, has more complex and diversified structure that is more complex and diversified, prevails among pharmaceutical intermediates, functional materials and farmland pharmaceuticals, is widely applied in the fields such as molecular machinery, materials chemistry and supramolecular chemistry, and also has a more promising application prospect in chemical production and clinical medicine; moreover, the preparation method provided by the invention is simple and is high in synthetic efficiency.

Provided is a 2,3-disubstituted indole derivative. The 2,3-disubstituted indole derivative has great biological activity and can be widely applied to light chemical industry, agriculture, medicine andother fields. Additionally, the invention also relates to a preparation method of the 2,3-disubstituted indole derivative. According to the preparation method, alkynyl aniline and substituted bromobenzene which are of different structures are subjected to a cascade reaction catalyzed by palladium to form a 2,3-disubstituted indole compound. Therefore, the method is simple, convenient, efficient and environmentally friendly.

The invention belongs to the field of organic synthesis, and especially relates to aryl alkyl thioether derivatives, and a preparation method thereof. Compared with common thioether derivatives, the aryl alkyl thioether derivatives possess following characteristics: the aryl alkyl thioether derivatives are polycyclic compounds; the structure is more complex and diverse; application prospect in the field of chemical production and clinical medicine is more promising. The preparation method comprises following steps: in a water-free oxygen-free system, a diyne compound, a hydrocarbyl alkyne bromide, anhydrous acetonitrile, a transition-metal catalyst, and an organic base are mixed and reacted so as to obtain an intermediate; at 90 to 100 DEG C, the intermediate, alkyl disulfide, and methylbenzene are mixed and reacted. The preparation method is capable of solving problems in the prior art that reaction route is too long; requirements on substrates and reaction conditions are strict; and expansion of replaced function groups is limited.

The invention provides a poly-substituted condensed aromatic derivative and a preparation method thereof. Compared with the prior art, in the preparation method, the poly-substituted condensed aromatic derivative is simply, conveniently and efficiently synthesized under the catalyst-free condition by utilizing transfer of witting reagent related electrons and other reaction processes from a new perspective, the reaction time is short, and the efficiency is high. In addition, a series of novel poly-substituted condensed aromatic derivatives are provided. Compared with common poly-substituted condensed aromatic derivatives, the poly-substituted condensed aromatic derivative is complicate and diversified in structure and also has wide application prospect in chemical production and clinic medicine.

The invention discloses a centralized combustion device applied to an internal heating type rotary furnace. The centralized combustion device comprises a furnace outer cylinder and a furnace inner cylinder; an inner cylinder push device is arranged inside the furnace inner cylinder; an outer cylinder returning device is arranged inside the furnace outer cylinder; the end part of the furnace outercylinder is in dynamic tight coupling with a centralized combustion end base; the centralized combustion end base is provided with a combustion isolator which extends into the furnace inner cylinder;the combustion isolator is provided with a centralized combustion channel; a slag falling opening is arranged between the centralized combustion end base and the furnace inner cylinder; the centralized combustion channel is provided with a plurality of combustion-supporting air supply pipelines; an annular flame retardant coating is arranged inside the furnace inner cylinder; an air stop device isarranged between the centralized combustion end base and the furnace inner cylinder which is arranged outside a material collection region; and the furnace inner cylinder is connected with an air replenishing device. According to the centralized combustion device disclosed by the invention, a raw material can be preheated by adopting the combustion heat; organic components can be separated out, pyrolyzed and vaporized; by virtue of the air flow, gaseous combustible substances can reach the centralized combustion channel and are centralized so that centralized and violent combustion can be easily formed, thus sufficient combustion of residual combustible substances in the raw material can be promoted, and harmful substances contained in tail gases can also be obviously reduced.

The invention discloses a composite stainless steel spherical digester which comprises a bracket, a spherical digester body, a transmission part, an air inlet, an air outlet, an air inlet pipe and a blowing pipe, wherein the spherical shell body is formed by compounding an outer carbon steel layer and an inner stainless steel layer. The stainless steel spherical digester is simple in structure, and the inner layer of the spherical shell is a stainless steel layer and has the advantages of high corrosion and wear resistance, so that the cost is reduced. According to the composite structure, the potential safety hazard of the spherical digester is eliminated, the service environment and the application range of the spherical digester are greatly improved, and the service life is prolonged. Compared with a carbon steel spherical digester, the composite stainless steel spherical digester has high corrosion resistance, a wide application range and an excellent performance; compared with a pure stainless steel spherical digester, the composite stainless steel spherical digester has the advantages that the cost is reduced by 50 percent, and the service effect and the service life are equal, so that the market application range is increasingly widened, the application prospect is wide, and the application is extended from the traditional papermaking and pulping industry to multiple fields of pharmacy, chemical fiber, biochemical engineering, environment friendliness and sanitary food.

The present invention provides a strain of Bifidobacterium breve and a method for culturing and use thereof. The Bifidobacterium breve is classified and named Bifidobacterium breve grx05, which has been preserved in China Common Microbial Bacteria on January 4, 2021 Species Preservation and Management Center, the preservation number is CGMCC No. 21589, and the preservation address is No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing, China. The Bifidobacterium breve provided by the invention is not only sensitive to most antibiotics, but also has better resistance to gastric acid and bile salt, thereby reducing its potential risks and making it have a relatively broad application prospect.

The invention provides a ferrocene derivative and a preparation method thereof. Compared with the prior art, in the absence of catalyst and additive as well as protection and with toluene as a solvent, a tetra-alkyne substrate reacts with ferrocene at 104-114 DEG C, wherein the reaction process comprises the following steps: cyclization of the tetra-alkyne substrate, generation of a benzyne intermediate through a HDDA reaction, and 4+2 cycloaddition reaction between the highly active benzyne intermediate and the cyclopentadiene of ferrocene to obtain the ferrocene derivative. The method breaksthrough the former knowledge that the ferrocene cannot experience a cycloaddition reaction, and also shows a broader application prospect in chemical production and clinical medicine. Moreover, the preparation method provided by the invention has the advantages of simplicity and convenience, high efficiency and short reaction time.

The invention provides a poly-substituted condensed aromatic derivative and a preparation method thereof. Compared with the prior art, in the preparation method, the poly-substituted condensed aromatic derivative is simply, conveniently and efficiently synthesized under the catalyst-free condition by utilizing transfer of witting reagent related electrons and other reaction processes from a new perspective, the reaction time is short, and the efficiency is high. In addition, a series of novel poly-substituted condensed aromatic derivatives are provided. Compared with common poly-substituted condensed aromatic derivatives, the poly-substituted condensed aromatic derivative is complicate and diversified in structure and also has wide application prospect in chemical production and clinic medicine.

The invention relates to the technical field of solar photovoltaic power generation application, particularly a mounting side waterproof structure of a photovoltaic battery piece. The mounting side waterproof structure comprises a plate body, wherein the plate body adopts an arc-shaped structure; T-shaped grooves are formed in the two side end planes of the plate body; rubber cushions are arrangedin the grooves; the rubber cushions extend to the outside of the plate body to be positioned below the side end planes; the two side end planes of the plate body are parallel to the horizontal plane;baffles are arranged at the two ends of the plate body; the lower end planes of the baffles are smaller than that of the plate body; first through holes are formed in the arc-shaped top of the platebody; fixed blocks are arranged outside the plate body; and the plate body and the fixed blocks are connected through the first through holes via screws. By virtue of the mounting side waterproof structure, the problems of non-waterproof property and non-attractive appearance after the photovoltaic battery piece is mounted on the roof can be solved; and the mounting side waterproof structure has wide application prospect in the technical field of the solar photovoltaic power generation application.

The invention provides o-mercapto phenol derivatives and a preparation method thereof. The preparation method comprises the following steps: a, synthesizing a precursor; b, synthesizing a target product; and c, purifying. Compared with the prior art, the invention provides a brand new synthetic method of poly-substituted o-mercapto phenol for generating a series of novel o-mercapto phenol derivatives. Compared with common o-mercapto phenol derivatives, the o-mercapto phenol derivatives prepared by the method provided by the invention have multiple rings, so that the o-mercapto phenol derivatives are more complex and diverse in structure and further show a broader application prospect in chemical industry production and clinical medicines.

The invention discloses an acyl chloride and alkyne addition product and a preparing method thereof. The preparing method includes the steps that sodium hydride is used as a catalyst, diisopropyl malonate and propargyl bromide are added into anhydrous acetonitrile, the mixture is put in an ice-water bath and stirred for reacting, and a white solid product is obtained after purification and separation; the product phenyl ethynyl bromide is mixed in an anhydrous oxygen-free catalytic system of Pd(PPh3)2Cl2 / CuI, triethylamine is used as alkali, anhydrous acetonitrile is used as solvent, a light brown solid product is obtained through stirring reacting at the room temperature as well as purification and separation, the light brown solid product reacts with adamantanecarbonyl-chloride in methylbenzene, and the acyl chloride and alkyne addition product is obtained through purification and separation. Compared with the prior art, the prepared beta-chloro-alpha, beta unsaturated ketone does not need a metal catalyst, is high in yield and more complex and verified in structure and will show broader application prospects in chemical industry production and clinic medicine.

The invention relates to an annulene derivative containing exocyclic double bonds and a preparation method of the annulene derivative. The preparation method comprises the following steps: a, synthesizing a precursor; b, synthesizing a target product; c, purifying. Compared with the prior art, a brand-new synthetic method for the polysubstituted annulene derivative containing the exocyclic double bonds is provided; compared with a general annulene derivative, the prepared annulene derivative containing the exocyclic double bonds is polycyclic and relatively complicated and diversified in structure, and has a relatively wide application prospect in chemical production and clinical medicines.

The invention provides a synthesis method of a 1,5-dicarbonyl compound. According to the method, under the conditions of employing triethylamine as alkali, an ionic liquid [BMIM] PF6 as a solvent and lithium tetrafluoroborate as an adjuvant, a series of novel 1,5-dicarbonyl compounds are generated through autoreaction of the prepared precursor compound; and the generated 1,5-dicarbonyl compounds have good non-corresponding stereoselectivity. Compared with an ordinary 1,5-dicarbonyl compound, the prepared 1,5-dicarbonyl compounds are complicated and diverse in structure, and also show a relatively wide application prospect in chemical production and clinical medicine.

The invention discloses a 5,6-dihydrobenzophenanthridines derivative and a preparation method thereof. The derivative is prepared by the palladium catalytic cyclization reaction from the precursor product diyne compound. Compared with the prior art, the preparation method is simple, has high yield, is easy to promote, and has wide application prospect in the field of chemical industry production, clinical medical, pesticide, molecule material and so on.

The invention discloses a 5,6-dihydrobenzophenanthridines derivative and a preparation method thereof. The derivative is prepared by the palladium catalytic cyclization reaction from the precursor product diyne compound. Compared with the prior art, the preparation method is simple, has high yield, is easy to promote, and has wide application prospect in the field of chemical industry production, clinical medical, pesticide, molecule material and so on.

The invention provides poly-substituted 3-phenyl phenol derivatives and a preparation method thereof. Compared with the prior art, a series of novel poly-substituted 3-phenyl phenol derivatives is provided. Compared with common poly-substituted 3-phenyl phenol derivatives, the prepared poly-substituted 3-phenyl phenol derivatives have a multi-ring structure, the structure is more complicated, and thus the provided derivatives have a wide application in industries such as chemical engineering, clinical medicine, materials, and the like. Furthermore, the provided preparation method has the advantages of simpleness, high efficiency, and short reaction time.

The invention provides an oxazine phenyl ether derivative and a preparation method thereof. In the state of no catalyst, no additive, and no protection, the invention uses toluene as a solvent, tetrakyne and 2-phenyl-3,4-di Hydrogen-2H-benzo[1,3]oxazin-4-one is reacted at 110-115°C for more than 15 hours. The reaction process is firstly cyclized by the tetrayne substrate itself, because the benzyne generated by the tetrayne is An electron-deficient intermediate, extremely unstable and highly active. Tetrayne reacts with HDDA to form a benzyne intermediate, which then undergoes nucleophilic nucleophilic reaction with 2‑phenyl‑3,4‑dihydro‑2H‑benzo[1,3]oxazin‑4‑one Addition to obtain oxazine phenyl ether derivatives. Compared with the prior art, the oxazine phenyl ether derivatives prepared by the present invention have multiple rings, and their structures are more complex and diverse, and the preparation method provided by the present invention is simple, short in reaction time and high in efficiency.