44results about How to "Broad use prospects" patented technology

The invention relates to a benzoin oxime derivative and a preparation method thereof. A structural formula of the benzoin oxime derivative is shown in the specification. The preparation method comprises the following steps: reacting malonate with propargyl bromide in anhydrous acetonitrile under the catalysis of sodium hydride to obtain a white solid product; by taking triethylamine as alkali, reacting the white solid product with phenylethynyl bromine or substituted phenylethynyl bromine in anhydrous acetonitrile under the catalysis of Pd(PPh3)2Cl2/CuI to obtain a light brown solid product; reacting the light brown solid product with benzoin oxime in toluene at 95-105 DEG C to obtain the benzoin oxime derivative. A brand new synthetic method of polysubstituted benzoin oxime is provided, and a series of new benzoin oxime derivatives are generated. Compared with normal benzoin oxime derivatives, the benzoin oxime derivative prepared by virtue of the preparation method has relatively complex and diverse structures by virtue of multiple cycles, and presents relatively wide application prospects in chemical industry production and clinic medicines.

The invention discloses a diphenyl telluride derivative and a preparation method thereof. Compared with the prior art, a series of novel diphenyl telluride derivatives are provided. Compared with ordinary diphenyl telluride derivatives, the prepared diphenyl telluride derivative has multiple rings, the structure is more complicated and diversified, the diphenyl telluride derivative has wider application prospect in chemical industry production and clinical medicines, the provided preparation method is simple and efficient, the reaction time is short, and the efficiency is high.

The invention provides a chimeric antigen receptor (CAR) polypeptide for pathogens. The chimeric antigen receptor polypeptide is provided with: (a) an extracellular domain comprising one or more antigen binding regions having pathogen-related antigen specificity; (b) a transmembrane domain; and (c) one or more copies of an intracellular signal domain of a 'eat-me' signal receptor, which can be specifically bound to a pathogen antigen and activate an endogenous silence type phagocytic clearance signal. Further, the invention also provides polynucleotides encoding the polypeptide, gene vectors,recombinant cells carrying chimeric antigen receptors, and a composition. The chimeric antigen receptor characteristically mediates recombinant cells to perform phagocytic clearance on the pathogens,and does not significantly release cytokines, so that a 'silence' type pathogen clearing mode is actually realized.

The invention discloses a multi-purpose gathering combustion type rotary furnace. The multi-purpose gathering combustion type rotary furnace comprises a furnace base. An outer furnace barrel and an inner furnace barrel are installed on the furnace base in a rotating mode and are synchronous. The two ends of the outer furnace barrel are connected with a feeding and discharging end base and a gathering combustion end base in a dynamic sealing mode correspondingly. One end of the inner furnace barrel is connected with a sealed feeding device. A combustion isolation body which stretches into the inner furnace barrel is arranged on the gathering combustion end base, a gathering combustion channel is formed in the portion, corresponding to a material gathering region, of the combustion isolationbody, and a slag falling opening is formed in the gathering combustion end base. A combustion supporting air supply pipe is arranged in the gathering combustion channel, and an annular flame retardant layer is arranged in the inner furnace barrel. A gas resistance device is arranged between the gathering combustion end base and the portion, located outside the material gathering region, of the inner furnace barrel, and the inner furnace barrel is connected with a gas supplement device. According to the multi-purpose gathering combustion type rotary furnace, the combustion heat can preheat rawmaterials, organic matter components can be precipitated and subjected to thermal decomposition to be gasified, the air flow enables the gaseous combustible materials to arrive at the gathering combustion channel and to be gathered, the centralized and powerful combustion is easily formed, and therefore the residual combustible materials inside the raw materials can be prompted to be sufficientlyburnt, and the number of hazardous substances in the tail gas can also be obviously reduced.

The invention discloses a benzodihydropyran ring derivative and a preparation method thereof. The malonate and propargyl bromide are used as initial raw materials to synthesize a benzodihydropyran ring derivative through a three-step reaction; and the raw material is simple and easy to obtain, the synthesis method is convenient and fast, and an efficient and fast synthesis path is provided for the preparation of the benzodihydropyran ring derivative.

The invention provides poly-substituted 3-phenyl phenol derivatives and a preparation method thereof. Compared with the prior art, a series of novel poly-substituted 3-phenyl phenol derivatives is provided. Compared with common poly-substituted 3-phenyl phenol derivatives, the prepared poly-substituted 3-phenyl phenol derivatives have a multi-ring structure, the structure is more complicated, and thus the provided derivatives have a wide application in industries such as chemical engineering, clinical medicine, materials, and the like. Furthermore, the provided preparation method has the advantages of simpleness, high efficiency, and short reaction time.

The invention provides a ferrocene derivative and a preparation method thereof. Compared with the prior art, in the absence of catalyst and additive as well as protection and with toluene as a solvent, a tetra-alkyne substrate reacts with ferrocene at 104-114 DEG C, wherein the reaction process comprises the following steps: cyclization of the tetra-alkyne substrate, generation of a benzyne intermediate through a HDDA reaction, and 4+2 cycloaddition reaction between the highly active benzyne intermediate and the cyclopentadiene of ferrocene to obtain the ferrocene derivative. The method breaksthrough the former knowledge that the ferrocene cannot experience a cycloaddition reaction, and also shows a broader application prospect in chemical production and clinical medicine. Moreover, the preparation method provided by the invention has the advantages of simplicity and convenience, high efficiency and short reaction time.

Provided is a 2,3-disubstituted indole derivative. The 2,3-disubstituted indole derivative has great biological activity and can be widely applied to light chemical industry, agriculture, medicine andother fields. Additionally, the invention also relates to a preparation method of the 2,3-disubstituted indole derivative. According to the preparation method, alkynyl aniline and substituted bromobenzene which are of different structures are subjected to a cascade reaction catalyzed by palladium to form a 2,3-disubstituted indole compound. Therefore, the method is simple, convenient, efficient and environmentally friendly.

The invention belongs to the field of organic synthesis, and especially relates to aryl alkyl thioether derivatives, and a preparation method thereof. Compared with common thioether derivatives, the aryl alkyl thioether derivatives possess following characteristics: the aryl alkyl thioether derivatives are polycyclic compounds; the structure is more complex and diverse; application prospect in the field of chemical production and clinical medicine is more promising. The preparation method comprises following steps: in a water-free oxygen-free system, a diyne compound, a hydrocarbyl alkyne bromide, anhydrous acetonitrile, a transition-metal catalyst, and an organic base are mixed and reacted so as to obtain an intermediate; at 90 to 100 DEG C, the intermediate, alkyl disulfide, and methylbenzene are mixed and reacted. The preparation method is capable of solving problems in the prior art that reaction route is too long; requirements on substrates and reaction conditions are strict; and expansion of replaced function groups is limited.

The invention provides a poly-substituted condensed aromatic derivative and a preparation method thereof. Compared with the prior art, in the preparation method, the poly-substituted condensed aromatic derivative is simply, conveniently and efficiently synthesized under the catalyst-free condition by utilizing transfer of witting reagent related electrons and other reaction processes from a new perspective, the reaction time is short, and the efficiency is high. In addition, a series of novel poly-substituted condensed aromatic derivatives are provided. Compared with common poly-substituted condensed aromatic derivatives, the poly-substituted condensed aromatic derivative is complicate and diversified in structure and also has wide application prospect in chemical production and clinic medicine.

The invention discloses a 5,6-dihydrobenzophenanthridines derivative and a preparation method thereof. The derivative is prepared by the palladium catalytic cyclization reaction from the precursor product diyne compound. Compared with the prior art, the preparation method is simple, has high yield, is easy to promote, and has wide application prospect in the field of chemical industry production, clinical medical, pesticide, molecule material and so on.