18 results about "Bromobenzene" patented technology

This invention provides a cyan-transparent electrochromic polymer, its preparation method, and its applications, belonging to the field of electrochromic polymer technology. The invention uses 6,6'-(2,6-dibromo-4H-cyclopentano[2,1-b:3,4-b']dithiophene-4,4-diyl)bis(hexyl-1-ol), 2,6-di(trimethyltin)-4,4-di(2-ethylhexyl)-dithiophenecyclopentadiene, and 4,7-dibromobenzo[c][1,2,5]thiadiazole as main raw materials, reacting them under the action of a catalyst to obtain a cyan-transparent electrochromic polymer. The film made from the cyan-transparent electrochromic polymer of this invention has an optical contrast ratio of 47.01% in the 719 nm wavelength range, a coloring time of 0.81 s, and a fading time of 0.32 s.

This invention discloses a method for synthesizing a dipeptide linker for antibody-coupled degradation, relating to the field of organic synthesis. 1-[(3S)-3-{[(4-{[(2-bromophenyl)oxy]methyl}phenyl)amino]carbonyl}-8-methyl-1-oxoylide-2,8-diazanon-1-yl]cyclobutane-1-carboxylic acid ethyl ester (CAS: 2760139-12-4) is a cleavable dipeptide linker for antibody-coupled degradation, which can be used to synthesize antibody-coupled active molecules. This invention uses readily available and inexpensive commercial raw material p-aminobenzyl alcohol as a starting material, and through seven conventional steps, obtains the target product with high purity and high yield. The starting material is inexpensive, the operation is simple, the reaction conditions are mild, and it can be prepared in large quantities at the hundred-gram scale, representing a completely new synthetic route.

The application discloses a preparation method and application of a hollow conjugated microporous polymer. It belongs to the field of photocatalytic organic synthesis and comprises the following steps: step S1, dispersing SiO2 nanosphere templates in a triethylamine solvent; step S2, adding 4,7-dibromo-2,1,3-benzothiadiazole, dichlorobistriphenylphosphine palladium and cuprous iodide; step S3, slowly adding a toluene solution of 1,3,5-triethynylbenzene; step S4, heating, stirring, washing, etching with a hydrofluoric acid solution, washing and drying to obtain the hollow conjugated microporous polymer. The hollow spherical structure of the hollow conjugated microporous polymer enhances light capture; high specific surface area and hierarchical pores promote mass transfer and active site exposure; the D-A type conjugated system constructed by BT units effectively narrows the band gap, expands the visible light response range and greatly improves the charge separation efficiency; and the all-organic composition makes the hollow conjugated microporous polymer environmentally friendly and relatively low in cost.

The application belongs to the technical field of chemical industry and discloses a preparation method, a condensing agent and application of a cosmetic peptide prolyl-prolyl-lysine.The method uses proline as a starting material to generate proline with a benzyl-protected amino group by combining with bromobenzene;then, in water, sodium salt is formed by using sodium bicarbonate as a condensing agent to form an active lipid, which is directly combined with unprotected proline to generate Bn-Pro-Pro-OH after reaction;then, Bn-Pro-Pro-OH is used in water, sodium salt is formed by using sodium bicarbonate, an active lipid is formed by using a condensing agent, and N6-Cbz-L-lysine is combined to generate Bn-Pro-Pro-Lys(Z)-OH;finally, hydrogenation is performed to generate the cosmetic peptide prolyl-prolyl-lysine.The method has the advantages that the product purity of the prolyl-prolyl-lysine tripeptide obtained by the method is high, the raw material cost is low, the operation is simple, the method is suitable for industrial production, and the method can meet the needs of the future skin care product industry.

This invention relates to the field of compound synthesis technology, specifically disclosing a method for synthesizing 7-(4-bromophenyl)-7H-dibenzo[c,g]carbazole. The method of this invention generates the target compound in one step through a catalytic coupling reaction of compound 1 with p-bromoaniline. This method utilizes inexpensive raw materials, significantly reducing production costs; it also features a short reaction time, mild reaction conditions, and simple process operation; the post-reaction processing is convenient, and high-purity products are easily obtained, making it suitable for large-scale production.

A preparation method for a morpholine-based organophosphine ligand includes the steps of: adding 1,3-dibromobenzene, morpholine, an inorganic base, and a first catalyst to a reactor under a nitrogen (N2) atmosphere, and using tetrahydrofuran (THF) as a reaction solvent; reacting a mixture at 45-55° C. for 5-7 h; lowering a reaction temperature to −75 to −80° C., and adding n-butyllithium (nBuLi); and raising the reaction temperature to 0° C. after stirring, and adding a second catalyst and a halophosphine reagent for reaction to obtain a morpholine-based organophosphine ligand. A method for synthesizing novel morpholine-based organophosphine ligands under mild conditions of the present disclosure has been successfully applied in palladium (Pd)-catalyzed carbon-nitrogen (C—N) bond formation reactions, demonstrating high efficiency and selectivity, simplifying reaction conditions, and broadening the scope of application.

The application discloses a one-pot preparation method of 3,4,5-trifluorobromobenzene. In an organic solvent, 2,6-difluoroaniline is used as raw material to obtain the product 3,4,5-trifluorobromobenzene through three steps of bromination, diazotization and fluorination at a certain temperature. The method has the advantages of multiple raw material sources, obvious cost advantage, safety and convenience, high total yield, less waste and the like, and is beneficial to industrialization.

This invention relates to the chiral resolution and scale-up of molecular materials. The invention utilizes the reaction of racemic 1-(4-bromophenylethylaminomethylphosphonic acid) (Rac-BrpempH2) with transition metal Ni2+ ions. Through a solvothermal reaction, the spontaneous resolution of racemic organophosphonic acid molecules is achieved via the molecular isomerism effect of the co-solvent butanol and the coordination-driven synergistic effect of the metal ions. Furthermore, the introduction of chiral amino acid molecules successfully induces the resolution and chiral scale-up of single chiral organophosphonic acid molecules. The advantages of this invention are that by controlling reaction conditions and introducing chiral inducers, a single macroscopic helical structure material can be successfully synthesized from racemic ligands, providing a new strategy for chiral resolution and opening new avenues for designing and constructing chiral coordination polymers with helical morphology.

The application discloses a polyether polyol potassium removal method using a covalent organic framework material, and relates to the technical field of polyether polyols. The application first synthesizes TbBab-COF, and then modifies the TbBab-COF to obtain a crown ether functionalized TbBab-ce-COF material through 4-bromobenzene-15-crown-5-ether; the TbBab-ce-COF material is directly added into crude polyether polyol, and the crown ether group selectively adsorbs potassium ions by using the specific recognition ability of the crown ether group to the potassium ions, so that refined polyether polyol is obtained through suction filtration; and the TbBab-ce-COF material after suction filtration can be regenerated and reused after being soaked in acid liquor. The application integrates multiple processes such as traditional neutralization, adsorption and filtration into one-step adsorption separation, greatly simplifies a process flow, reduces energy consumption, avoids the generation of salt-containing wastewater, and the TbBab-ce-COF material can be reused, so that the application has a wide application prospect in the field of polyether polyol post-treatment.

This invention discloses a method for synthesizing 4-fluoro-3,5-dimethylphenylhydrazine hydrochloride, belonging to the field of pharmaceutical intermediate synthesis technology. The synthesis method involves the following steps: copper halide, hydrazine additives acting as catalysts, a phase transfer catalyst, K3PO4, and 4-fluoro-3,5-dimethylbromobenzene are added to a solvent, and the temperature is raised to 80℃-100℃; hydrazine hydrate is added dropwise to the above mixture, and after the addition is complete, the temperature is maintained at 80℃-100℃ for 6-10 hours; after the reaction is complete, the temperature is lowered to room temperature, dichloromethane is added, the mixture is filtered, and the filtrate is separated, the aqueous layer is removed, and the organic layer is washed with saturated brine; the washed organic phase is acidified to pH 2-3 to obtain crude 4-fluoro-3,5-dimethylphenylhydrazine hydrochloride; the crude product is recrystallized to remove impurities, yielding a finished product with a purity of over 99%. This invention utilizes readily available raw materials, achieves high yield, produces a high-purity finished product, has a simple preparation method, a short processing cycle, and low manufacturing cost.

This invention belongs to the field of organic synthesis technology and provides a method for preparing a key intermediate of ambroxol hydrochloride. The method includes the following steps: methyl 2-aminobenzoate reacts with a brominating reagent under the action of an initiator to generate methyl 2-amino-3,5-dibromobenzoate via a bromination reaction; subsequently, methyl 2-amino-3,5-dibromobenzoate is reduced to 2-amino-3,5-dibromobenzyl alcohol in a reduction system; finally, under the action of an oxidizing agent, 2-amino-3,5-dibromobenzyl alcohol is further oxidized to form the target compound 2-amino-3,5-dibromobenzaldehyde. The optimized process has mild reaction conditions, conforms to green and environmentally friendly principles, significantly improves route safety, uses inexpensive and readily available raw materials, and achieves high product yield and purity, making it suitable for industrial production.

The application provides an application of a strain of Tolypocladium inflatum ZJPH2105 in preparing a chiral aromatic alcohol through asymmetric reduction of an aromatic ketone. The product obtained through catalysis of the strain of Tolypocladium inflatum ZJPH2105 has an e.e. value of greater than 99.9%, the strain is green and safe, easy to cultivate, and rich in source, and the conversion process does not need to add expensive coenzyme, and has the characteristics of low cost, green and environment-friendly conversion process and the like. The application uses the strain of Tolypocladium inflatum ZJPH2105 as a biological catalyst to reduce 4'-bromo-2,2,2-trifluoroacetophenone, when the substrate concentration is 10 mM, the yield of the target product (S)-1-(4-bromophenyl)-2,2,2-trifluoroethanol can reach 98.2%, and the e.e. value is greater than 99.9%.

This invention belongs to the field of molecular synthesis and materials technology, and discloses a method for preparing small molecule materials based on benzothiophene-benzodithiophene (DBDTT) and benzoselenophene-benzodiselenophene, as well as their applications. The method includes: using 1-chloro-2-iodobenzene or 1-chloro-2-bromobenzene and trimethylethynylsilane as raw materials, after a stalk coupling reaction, removing the TMS (trimethylsilyl group) with potassium hydrofluoric acid to obtain a key intermediate; using S8 or Se as a sulfur source or selenium source, and potassium carbonate as a base, a series of fused-ring thiophene / selenophene small molecule materials are synthesized through a cascade cyclization reaction. The substrates of this invention are simple to synthesize, the raw materials are inexpensive and readily available; no metals are involved; the reaction can be carried out under air conditions; the reaction efficiency is high, with three rings fused simultaneously in a single step; the yield is moderate, and even at a large scale (10 mmol), the yield can still reach 58%. Therefore, this method is suitable for industrial production.

This invention discloses a color-changing polyimide ether ketone polymer, its preparation method, and its applications, belonging to the technical field of color-changing material preparation. The preparation method involves: reacting 4,4'-dimethoxydiphenylamine with boron tribromide to synthesize 4,4'-dihydroxydiphenylamine; reacting p-bromobenzoyl chloride, anhydrous aluminum chloride, and fluorobenzene to synthesize 4-bromo-4'-fluorobenzophenone; reacting 4-bromo-4'-fluorobenzophenone, p-phenylenediamine, sodium tert-butoxide, Pd2(dba)3 catalyst, and BINAP under heat to obtain bis(4-fluorophenylbenzophenone)-4,4'-iminodiphenylamine; and reacting 4,4'-dihydroxydiphenylamine, bis(4-fluorophenylbenzophenone)-4,4'-iminodiphenylamine, and anhydrous potassium carbonate under heat to obtain the polyimide ether ketone polymer. This color-changing material exhibits excellent thermal stability, and the synthesis route is simple and easy to operate, effectively solving the problems existing in the prior art.

This invention provides a method for synthesizing deuterated iodobenzene compounds, comprising a halogen exchange reaction of a deuterated bromobenzene substrate and an iodide in a solvent under heating in the presence of a copper catalyst and a ligand 2,2'-bipyridine or its derivative, with a yield of over 90.0%.

This invention belongs to the field of chemical mechanical polishing (CMP) and discloses the application of a corrosion inhibitor in a copper CMP slurry, the copper CMP slurry, and its application. The corrosion inhibitor is a compound represented by formula (I) and / or formula (II); R is selected from phenyl, 4-methylphenyl, 4-(trifluoromethyl)phenyl, 4-bromophenyl, or 4-chlorophenyl. The corrosion inhibitor provided by this invention has 1,2,3-triazole as its core structure, utilizing its strong coordination with the copper surface to form stable anchor points. Through specific substituents, the density and chemical stability of the adsorption film are regulated. Under alkaline conditions, it can effectively inhibit the corrosion of copper during the CMP process, significantly improve the quality of the polished copper surface, and possess both high-performance polishing and environmentally friendly characteristics.

This invention provides a chlorine storage medium, a method for storing chlorine gas in the storage medium, and a method for separating chlorine gas. The storage medium is composed of at least one organic salt and at least one organic solvent, wherein the organic salt is selected from one or more of tetraalkylphosphonium and tetraalkylamine, and the organic solvent is selected from one or more of bromobenzene, propylene glycol phenyl ether, 4-chlorodiphenyl ether, 3,4-dichlorodiphenyl ether, pyridine, 2-chloropyridine, and 2,4-dichloropyridine. The storage medium of this invention is a low-viscosity liquid under working conditions, resulting in a high chlorine storage rate and a high chlorine storage density per unit mass, while also facilitating transportation. The storage medium of this invention effectively reduces the saturated vapor pressure of chlorine gas at room temperature, effectively reducing the risk to environmental safety. This storage medium enables the controlled release of chlorine gas.