93 results about "Bromobenzene" patented technology

The invention relates to a synthesis process of an omarigliflozin intermediate, and belongs to the technical field of drug synthesis, one-step efficient conversion is adopted in the process of synthesizing the omarigliflozin intermediate, p-bromophenylhydrazine hydrochloride is used as a starting raw material, and a target product is obtained through indole cyclization, alkali precipitation and acidification crystallization. Toluene plays a role in cyclization and dehydration in a high-temperature reflux process, in a purification process of alkali precipitation and acidification crystallization, a sodium hydroxide aqueous solution is utilized to hydrolyze and convert a product into water-soluble sodium salt, the water-soluble sodium salt enters a water phase, a toluene layer containing a large amount of organic impurities and the water phase are layered in a standing and layering process, and the organic impurities in the toluene layer are removed; the preparation method comprises the following steps of: preparing a sodium salt, acidifying in a water phase by using hydrochloric acid, changing the sodium salt form of the product into an acid form, and crystallizing from the water phase, which is equivalent to recrystallization purification, so that the prepared product has higher purity, the purity is stabilized at 98% or above, and the purity of the product can meet the quality standard of medical intermediates.

The application provides an ester-based electrolyte containing a bromobenzene additive for a sodium metal battery and a sodium metal battery, the ester-based electrolyte comprising a bromobenzene additive, an ester-based solvent and a sodium salt; the bromobenzene additive accounts for 1-10 vol% of the ester-based electrolyte. The electrolyte realizes spherical growth of sodium and reduces the formation of 'dead sodium'; the amount of the electrolyte additive is small, the effect of improving the sodium metal deposition morphology and cycle stability is remarkable, and the electrolyte has great industrialization potential.

Belonging to the technical field of fine chemical product separation and purification, the invention discloses a beta-bromophenylethane rectification purification process, which comprises the steps of system negative pressure pretreatment, falling film evaporation directional separation, structured packing layer gas-liquid mass transfer, precise reflux ratio regulation and control, segmented collection (front fraction-qualified product), and residual liquid treatment and system circulation. According to the process, the negative pressure of a system is stabilized at 800-1200 Pa, the material temperature of a falling film evaporation discharging end is controlled at 125-135 DEG C, the feeding flow is stabilized at 1.8-2.2 m / h, the reflux ratio is regulated and controlled at 0.8: 1-1.2: 1, and the process realizes efficient purification of beta-bromopheny ethane through precise negative pressure control, synergistic linkage of falling film evaporation and a rectifying tower, segmented material collection and a circular treatment mechanism, so that the process is suitable for industrial production of beta-bromopheny ethane. According to the method, the purity of beta-bromopheny ethane can stably reach 99.5% or above, the material recovery rate is increased to 92% or above, energy consumption is reduced by 15-20% compared with that of a traditional process, material thermal decomposition loss is avoided, and the method is suitable for industrial large-scale production.

The invention belongs to the technical field of pesticide chemistry, and particularly relates to an application of a substituted phenylhydrazine copper salt complex as an agricultural fungicide, the structural general formula of the substituted phenylhydrazine copper salt complex is [Cu (ArNHNH2) 2] Xn, Ar is selected from 3-chlorphenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, the compound is prepared from 2, 6-dichlorophenyl, p-trichloromethoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-bromophenyl, 4-nitrophenyl, 4-cyanophenyl and 4-carboxyphenyl, and the compound is prepared from 2, 6-dichlorophenyl, p-trichloromethoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-bromophenyl, 4-nitrophenyl, 4-cyanophenyl and 4-carboxyphenyl. X is selected from SO4 <->, Cl <-> and NO3 <->; n is equal to 1-2. The substituted phenylhydrazine copper salt complex disclosed by the invention has remarkable inhibitory activity on plant pathogenic bacteria, has very high inhibition rate on three plant pathogenic fungi, namely fusarium graminearum, rhizoctonia solani and sclerotium rolfsii, can be used as a safe and efficient novel bactericide, and is applied to prevention and treatment of various crop diseases.

The invention belongs to the technical field of medicine preparation, and particularly relates to a fenoprofen calcium preparation method which comprises the following steps: 1) m-hydroxyacetophenone and bromobenzene generate an intermediate 1, namely m-phenoxyacetophenone under the action of alkali and cuprous iodide; 2) reacting the intermediate 1 with ethyl chloroacetate under the action of strong base, and then performing hydrolysis and decarboxylation reaction to generate an intermediate 2, namely 2-(3-phenoxy phenyl) propionaldehyde; the invention discloses a preparation method of fenoprofen calcium, which comprises the following steps: (1) preparing fenoprofen, (2) preparing fenoprofen, (3) carrying out oxidation reaction on an intermediate 2 to obtain fenoprofen, (4) reacting fenoprofen with a sodium hydroxide solution to obtain fenoprofen sodium, and (5) salifying fenoprofen sodium with a calcium chloride solution to obtain fenoprofen calcium.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a synthetic method of deuterated toluene-D3, which comprises the following steps: reacting deuterated iodomethane with magnesium to obtain a Grignard reagent deuterated methyl magnesium iodide; and then carrying out coupling reaction on the deuterated methyl magnesium iodide and bromobenzene under the catalysis of a nickel metal catalyst to obtain the deuterated toluene-D3. The synthesis method solves the problems of many byproducts, high cost and low utilization rate of deuterated raw materials when the existing toluene synthesis process is used for preparing semideuterated toluene, realizes efficient synthesis of high-purity deuterated toluene-D3, greatly reduces the generation of polymethyl compounds, and is short in production period and simple in post-treatment.

The invention discloses a method for preparing m-fluoroaniline, which comprises the following step of: reacting m-bromofluorobenzene with secondary amine in a solvent in the presence of sodium hydride to obtain an m-fluoroaniline compound. According to the method, secondary amine and m-fluorobromobenzene are used as raw materials, m-fluoroaniline is prepared through reaction under NaH, all the raw materials are cheap and easy to obtain, the reaction is simple and reliable, operation is easy, and the method is a novel method for preparing m-fluoroaniline. The method does not need transition metal catalysis, reagents are cheap and easy to obtain, operation is simple, and the substrate range is wide; the method for preparing the m-fluoroaniline compound has application value in medicine synthesis.

The present invention relates to emulsifiable concentrate formulations comprising the herbicides pyrasulfotole and bromoxynil.

The invention belongs to the technical field of chemical engineering, and discloses a preparation method, a condensing agent and application of beauty peptide prolyl-prolyl-lysine, and the method comprises the following steps: using proline as an initial raw material, and reacting with benzyl bromide to generate proline with benzyl protecting amino; in water, sodium bicarbonate is used for preparing sodium salt, the sodium salt and a condensing agent are used for preparing active lipid, the active lipid and unprotected proline directly react, and Bn-Pro-Pro-OH is obtained after the reaction is completed; the preparation method comprises the following steps: preparing a sodium salt from Bn-Pro-Pro-OH and sodium bicarbonate in water, preparing active lipid from the sodium salt and the active lipid by using a condensing agent, and condensing the active lipid and N6-Cbz-L-lysine to obtain Bn-Pro-Pro-Lys (Z)-OH; and finally, hydrogenating to obtain the beauty peptide prolyl-prolyl-lysine. The prolyl-prolyl-lysine tripeptide product obtained by the method disclosed by the invention is relatively high in purity, low in raw material cost, simple to operate and suitable for industrial production, and can meet the requirements of the future skin care product industry.

The application provides a preparation method of 2,4,6-trifluorobenzoic acid, which comprises the following steps: 1) subjecting 1,3,5-trifluorobenzene to a bromination reaction to obtain 2,4,6-trifluorobromobenzene; and 2) subjecting the 2,4,6-trifluorobromobenzene to a Grignard reaction to obtain 2,4,6-trifluorobenzoic acid. The method has the advantages of short flow, simple process, high molar yield and high purity of 2,4,6-trifluorobromobenzene, low cost of 2,4,6-trifluorobenzoic acid prepared by the method, and relatively environmentally-friendly and safe operation process, and is suitable for large-scale production.

This invention provides a cyan-transparent electrochromic polymer, its preparation method, and its applications, belonging to the field of electrochromic polymer technology. The invention uses 6,6'-(2,6-dibromo-4H-cyclopentano[2,1-b:3,4-b']dithiophene-4,4-diyl)bis(hexyl-1-ol), 2,6-di(trimethyltin)-4,4-di(2-ethylhexyl)-dithiophenecyclopentadiene, and 4,7-dibromobenzo[c][1,2,5]thiadiazole as main raw materials, reacting them under the action of a catalyst to obtain a cyan-transparent electrochromic polymer. The film made from the cyan-transparent electrochromic polymer of this invention has an optical contrast ratio of 47.01% in the 719 nm wavelength range, a coloring time of 0.81 s, and a fading time of 0.32 s.

This invention discloses a method for synthesizing a dipeptide linker for antibody-coupled degradation, relating to the field of organic synthesis. 1-[(3S)-3-{[(4-{[(2-bromophenyl)oxy]methyl}phenyl)amino]carbonyl}-8-methyl-1-oxoylide-2,8-diazanon-1-yl]cyclobutane-1-carboxylic acid ethyl ester (CAS: 2760139-12-4) is a cleavable dipeptide linker for antibody-coupled degradation, which can be used to synthesize antibody-coupled active molecules. This invention uses readily available and inexpensive commercial raw material p-aminobenzyl alcohol as a starting material, and through seven conventional steps, obtains the target product with high purity and high yield. The starting material is inexpensive, the operation is simple, the reaction conditions are mild, and it can be prepared in large quantities at the hundred-gram scale, representing a completely new synthetic route.

The invention discloses a cobalt-doped three-dimensional porphyrin graphite monoalkyne catalyst as well as a preparation method and application thereof. The catalyst is marked as Co-Por-GY / MWCNTs (multi-walled carbon nanotubes); the material is composed of a two-dimensional cobalt porphyrin graphite alkynyl film Co-Por-GY and multi-walled carbon nanotubes (MWCNTs), the cobalt porphyrin graphite alkynyl film wraps the MWCNTs, and the cobalt porphyrin graphite alkynyl film and the MWCNTs jointly form a three-dimensional structure; according to the cobalt porphyrin graphite monoacetylene thin film Co-Por-GY, a stable two-dimensional conjugated structure is formed by connecting a metalloporphyrin complex 5, 10, 15, 20-tetra (4-bromophenyl) cobalt porphyrin and butynedioic acid through a decarboxylation coupling reaction. The preparation method comprises the following four key steps: synthesizing the TBPP, doping the Co-TBPP, purifying the MWCNTs and finally assembling the composite catalyst. The catalyst is used for oxygen reduction reaction (ORR), the structural stability and the catalytic performance are remarkably improved, and the catalyst has obvious advantages in the aspects of the preparation process and the actual application effect.

The application discloses a preparation method and application of a hollow conjugated microporous polymer. It belongs to the field of photocatalytic organic synthesis and comprises the following steps: step S1, dispersing SiO2 nanosphere templates in a triethylamine solvent; step S2, adding 4,7-dibromo-2,1,3-benzothiadiazole, dichlorobistriphenylphosphine palladium and cuprous iodide; step S3, slowly adding a toluene solution of 1,3,5-triethynylbenzene; step S4, heating, stirring, washing, etching with a hydrofluoric acid solution, washing and drying to obtain the hollow conjugated microporous polymer. The hollow spherical structure of the hollow conjugated microporous polymer enhances light capture; high specific surface area and hierarchical pores promote mass transfer and active site exposure; the D-A type conjugated system constructed by BT units effectively narrows the band gap, expands the visible light response range and greatly improves the charge separation efficiency; and the all-organic composition makes the hollow conjugated microporous polymer environmentally friendly and relatively low in cost.

The invention discloses short-chain dehydrogenase for synthesis of (S)-1-(2-methoxy-3-bromophenyl) ethanol as well as a mutant, a coding gene, a plasmid, a genetically engineered bacterium and application of the short-chain dehydrogenase, and belongs to the technical field of biocatalysts. The mutant is obtained by mutating methionine at the 97th site into isoleucine on the basis of a wild type enzyme shown in SEQ ID NO.1 (SEQ ID NO.3). The invention further discloses a preparation method of the short-chain dehydrogenase. The invention also provides a coding gene, an expression vector, a genetically engineered bacterium and a double-enzyme catalytic system containing the mutant and formate dehydrogenase. The system can efficiently and highly selectively catalyze and synthesize the target chiral alcohol under mild conditions, and the conversion rate is gt; 95%, eet; 99% of the method is suitable for green preparation of the key intermediate of the medicine lutrombopag.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 4-bromocyclopropylbenzene. The method comprises the following steps: in step 1, bromobenzene, a Lewis acid and 3-chloropropionyl chloride are reacted to obtain 4-bromo-3-chloropropiophenone; in step 2, 4-bromo-3-chloropropiophenone and a reducing agent are reacted to obtain 4-bromochloropropylbenzene; and in step 3, 4-bromochloropropylbenzene is reacted under the action of an alkali catalyst to obtain 4-bromocyclopropylbenzene. The method has the advantages that common reagents are used in each step, the cost of raw materials is low, the synthesis process is short, the yield is high, there is no harsh reaction condition, the method is safe, convenient to operate, friendly to the environment, suitable for large-scale industrial production, and has a good application prospect.

This invention provides a ( E This invention relates to the field of pharmaceutical synthesis technology and provides a method for synthesizing 3,5-dihydroxy-4-isopropylstilbene. The method comprises three steps: starting with 3,5-dimethoxy-bromobenzene as a starting material, isopropylation is carried out under acidic conditions to obtain 3,5-dimethoxy-4-isopropylstilbene; further, a Heck reaction is performed with styrene under palladium catalysis to obtain (…). E )-3,5-dimethoxy-4-isopropylstilbene; demethylation reaction yields the ( E 3,5-Dihydroxy-4-isopropylstilbene. Compared to existing synthetic routes, the synthetic method of this invention significantly shortens the synthetic path, has higher atom utilization, higher product yield, and is environmentally friendly.

The invention belongs to the technical field of chemical analysis, and particularly relates to a sample pretreatment technology and an analysis method of a triazine herbicide. The ionic type conjugated microporous polymer is formed by polymerization of 2, 4, 6-tri (4-ethynyl phenyl)-1, 3, 5-triazine (TEPT) and 1, 3-bis (4-bromophenyl)-1H-imidazole-3-onium bromide, and the ionic type conjugated microporous polymer is formed by polymerization of 1, 3-bis (4-bromophenyl)-1H-imidazole-3-onium bromide. The ionic type conjugated microporous polymer is prepared by cross coupling of 2, 4, 6-tri (4-ethynyl phenyl)-1, 3, 5-triazine (TEPT) and 1, 3-bis (4-bromophenyl)-1H-imidazole-3-onium bromide, and the ionic type conjugated microporous polymer is prepared by cross coupling of 2, 4, 6-tri (4-ethynyl phenyl)-1, 3, 5-triazine (TEPT) and 1, 3-bis (4-bromophenyl)-1H- The ionic conjugated microporous polymer is used for preparing a solid phase extraction (SPE) small column, an SPE-LC-MS / MS is established after the extraction condition is optimized, and the SPE-LC-MS / MS is used for selective enrichment and accurate detection of trace triazine herbicides in environmental water bodies (such as underground water and waste water) and food samples.

The application discloses a method for continuously preparing tris(tribromophenoxy) triazine, relates to the technical field of organic chemical synthesis, and is characterized in that 2,4,6-tribromophenol, cyanuric chloride and sodium hydroxide are used as raw materials, a complex organic solvent system is constructed, mixed solution A and mixed solution B are prepared respectively, and the two solutions and a sodium hydroxide solution are continuously fed into a multi-stage series reactor to react; the obtained crude product after the reaction is sequentially subjected to alkali washing, acid washing, water washing and a micro-washing system, and then subjected to a continuous solvent recovery and pressure filtration step, so that a high-purity tris(tribromophenoxy) triazine product is finally obtained. The method realizes full-liquid continuous feeding through the complex solvent, improves feeding stability and reaction control precision, strengthens reaction conversion efficiency and inhibits byproduct generation through the multi-stage liquid-liquid heterogeneous reaction system, improves washing efficiency and impurity control ability through the micro-washing system, and significantly improves product purity, yield and thermal stability, so that the method has a good industrial application prospect.

The invention discloses a conjugated microporous polymer material as well as a preparation method and application thereof in photocatalysis, and belongs to the technical field of organic photoelectric materials and photocatalysis. According to the preparation method of the conjugated microporous polymer material, 1, 3, 5-trivinyl benzene and aryl halide ligands (such as 1, 4-dibromobenzene, 1, 3, 5-tribromobenzene and the like) are used as raw materials, palladium acetate is used as a catalyst, and the conjugated microporous polymer material is synthesized through a Heck coupling reaction by a hydrothermal method. The prepared conjugated microporous polymer material can generate photo-generated charges under an illumination condition, shows semiconductor-like characteristics and a two-dimensional plane structure, and is suitable for photocatalytic degradation of organic pollutants in water and reduction of carbon dioxide. The photocatalyst has a remarkable degradation effect on tetracycline hydrochloride under visible light and can be used for photocatalytic reduction of carbon dioxide to generate useful products. The material is stable in structure, large in specific surface area and reasonable in pore size distribution, and has a good application prospect.

The invention discloses a quaternary ammonium salt PCR (Polymerase Chain Reaction) hot start reagent as well as a preparation method and application thereof, the chemical name of the PCR hot start reagent is 5 ', 5' '-bis (4-bromophenyl)-2', 2 '', 4 ', 4' ', 6', 6 ''-hexamethyl-1, 1 ': 3', 1 ': 3', 1 '''quaternary ammonium salt, and the PCR hot start reagent is a compound formed by removing two bromine substituents in a parent nucleus molecule with the CAS number of 1093856-24-6 of quaterphenyl quaternary ammonium salt. The PCR hot start reagent is suitable for gene cloning, clinical diagnosis, gene detection and other scenes with high specificity requirements, can effectively inhibit non-specific amplification at low temperature, improves the specificity of PCR reaction and product purity, and has popularization and application values.

The invention discloses three kinds of ortho-substituted diaryl benzene weak acting group organic light-emitting materials with narrow-band emission. The three kinds of ortho-substituted diaryl benzene weak acting group organic light-emitting materials are a compound 19-Naph-Phen-Ben, a compound 99-Phen-Ben and a compound 91-Phen-Pyre-Ben. According to the preparation method disclosed by the invention, 9-(2-bromophenyl) phenanthrene is used as a raw material, and the 9-(2-bromophenyl) phenanthrene and arylboronic acid are subjected to suzuki coupling reaction to obtain corresponding ortho-substituted diaryl benzene. According to the ortho-substituted diaryl benzene weak acting group organic light-emitting material, space conjugation can be regulated and controlled by changing the size of an aryl element, so that a vibration energy level emission peak is inhibited, ultra-narrow band emission with the half-peak width smaller than 10 nm is finally achieved, and the ortho-substituted diaryl benzene weak acting group organic light-emitting material has the potential of being applied to photoelectric devices.

The invention discloses a synthesis method of 3-bromo-6-chloro-2-fluorobenzoic acid, and is characterized in that the synthesis method of 3-bromo-6-chloro-2-fluorobenzoic acid comprises the following steps: S1001, dissolving 2-chloro-6-fluorobromobenzene in an organic solvent I, cooling to-80 DEG C to-50 DEG C, then adding a lithium diisopropylamide solution, stirring for 20-40 minutes, then adding dry ice, stirring for 20-40 minutes, cooling to-80 DEG C to-50 DEG C, cooling to-80 DEG C to-50 DEG C, then adding 2-chloro-6-fluorobromobenzene, and then adding an organic solvent II; and then naturally heating to room temperature, and stirring to react for 10-30 hours. And S1002, after the reaction is completed, carrying out post-treatment on the reaction liquid to obtain the target compound 3-bromine-6-chloro-2-fluorobenzoic acid.

This invention discloses a self-fluorescent, high melt strength modified polypropylene, its preparation method, and its applications. The first step involves synthesizing polypropylene-A containing bromophenyl groups in its side chains, followed by the synthesis of polypropylene-B containing styrene groups in its side chains. Finally, polypropylene-A and polypropylene-B undergo a substitution reaction of their side chain groups under the action of a catalyst to generate a modified polypropylene with tetraphenylvinyl groups exhibiting aggregation-induced emission. The synthesized modified polypropylene product not only exhibits fluorescence but also has a significantly higher melt strength than ordinary polypropylene, making it suitable for manufacturing lightweight, heat-insulating polypropylene products such as foamed polypropylene.

The application discloses a kind of multifunctional poly-alpha-olefin composite material and its preparation method and application.The composite material includes high syndiotactic poly-alpha-olefin matrix A (rrrr>99%) and doped 2,6-naphthalene dimethyl formaldehyde, and the doping mass fraction is 0.02~4 wt%.The preparation method is: first, polymer A is obtained by polymerizing monomer 4-bromophenyl but-3-en-1-yl sulfide through rare earth catalytic system catalysis, then it is mixed and dispersed with 2,6-naphthalene dimethyl formaldehyde in organic solvent, and vacuum drying is obtained.The composite material has self-repairing efficiency>90% (60℃,1~4 h), shape memory fixing rate and recovery rate>90%, 365 nm ultraviolet light under fluorescent changes from blue to orange and room temperature phosphorescence characteristics.The material can be used in anti-fake, optical information storage and 3D printing field.

The invention discloses a nano composite material which is prepared by taking halloysite nanotubes as a base material and has room-temperature phosphorescence performance and a preparation method of the nano composite material, and belongs to the technical field of fluorescent materials. The nano composite material with the room temperature phosphorescence performance is prepared from the following raw materials: a polyacrylamide grafted halloysite nanotube and 2, 4, 6-tri-(4-bromophenyl)-[1, 3, 5] triazine. Polyacrylamide grafted halloysite nanotubes and 2, 4, 6-tri-(4-bromophenyl)-[1, 3, 5] triazine are used as raw materials, the composite carbon dot material with room-temperature phosphorescence performance is successfully prepared through a thermal induction in-situ reaction, and the product structure is proved to accord with the expectation based on the characterization of the structure and the microstructure. The preparation method disclosed by the invention is simple and convenient, extremely short in time consumption and easy to prepare, does not need a solvent or high-temperature and high-pressure reaction conditions, and has a good application prospect. The prepared HNTs-TBPT can emit yellow light (the peak value is 500 nm), and the phosphorescence service life tau is 266.0 ms.

The invention relates to a modified textile comprising a) a textile substrate; and, b) a lactam coating; and to the use of a lactam to impart anti-biofilm properties to a textile; and to the use of a lactam to inhibit biofilm growth on a textile substrate; wherein the lactam is selected from: (I) 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one; and (II) 5-methylene-4-(p-tolyl)pyrrol-2-one; (III) 4-(4-bromophenyl)-5-methylene-pyrrol-2-one; (IV) 4-(3-chlorophenyl)-5-methylene-pyrrol-2-one; (V) 4-(2-fluorophenyl)-5-methylene-pyrrol-2-one; and (VI).

The invention discloses a 2, 6-diethyl-4-methyl bromobenzene full-continuous flow synthesis process and a reaction device thereof, and relates to the technical field of compound synthesis. A reaction substrate and a sodium nitrite solution mixed with a catalyst are respectively input into a full-continuous flow shear reaction device through a feed port; after flowing through the temperature zone 1, the mixture is mixed with hydrobromic acid and enters a temperature zone 2 to complete a diazotization reaction, a diazotization reaction solution is obtained, the diazotization reaction solution flows out of the temperature zone 2, enters the bromination unit, reacts with a bromination reagent in the bromination unit, sequentially flows through a temperature zone 3 and is output from a discharge port, and a final product 2 is obtained after extraction, water washing, desolvation and distillation. The catalyst is 2, 6-diethyl-4-methyl bromobenzene. A continuous process is adopted, so that the difficulty of industrial application is greatly reduced; and during industrial amplification, the required production scale can be obtained through one-time amplification without tedious and complex multi-time step-by-step amplification and adjustment and optimization of process conditions and parameters, so that manpower, material resources and project development time are greatly saved.

The application belongs to the technical field of synthesis of organic light-emitting material intermediates, and particularly relates to a preparation method of 2-bromo-9-phenyl-9H-carbazole, which comprises the following steps: under inert gas, 2-nitroaniline and a bromine reagent are subjected to an electrophilic aromatic substitution reaction to generate an intermediate A-1; under acidic conditions, sodium nitrite and the intermediate A-1 are subjected to a diazotization reaction to generate a diazonium salt, and then under alkaline conditions, the diazonium salt is coupled with benzene to generate an intermediate A-2; the intermediate A-2 and triphenylphosphine are subjected to a reaction to generate a carbene, and then the carbene is subjected to a ring-closing reaction to generate an intermediate A-3; and the intermediate A-3 and bromobenzene are subjected to an Ullmann reaction to obtain 2-bromo-9-phenyl-9H-carbazole. The new method has the advantages of cheap and readily available raw materials, simple process, high yield, high continuous degree of reaction, short production cycle, low production cost and suitability for industrial production.