173 results about "Benzothiophene" patented technology

The invention belongs to the technical field of organic dye synthesis and application, and discloses a conjugated compound containing a benzothiophenazine structure as well as a preparation method and application thereof, and the conjugated compound containing the benzothiophenazine structure has excellent photophysical properties, singlet oxygen yield and superoxide anion generation capacity. The novel conjugated compounds ENBO-NI and ENBS-NI containing benzothiophenazine structures are successfully prepared by replacing a benzene ring of Nile blue with a cycloalkane structure and adjusting the electron donating ability of an R1 group. The two compounds have near infrared fluorescence emission, good solubility and relatively high ROS yield. Compared with a classical photosensitizer NB, the singlet oxygen yield of ENBO-NI is increased by about 117.65%, and the singlet oxygen yield of ENBS-NI is as high as 70%. The absorption wavelength of the conjugated compound is in a red light wave band. The preparation process is simple and efficient, large-scale production is easy, and the preparation method has a wide clinical application prospect.

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

The invention relates to the technical field of catalysts, in particular to a desulfurization catalyst and application thereof in hydrodesulfurization. The desulfurization catalyst adopts a hollow core shell, a weak acid site is constructed on a shell surface, and a boron-containing polymerization network is formed through surface-initiated polymerization; and linear / branched polyethyleneimine complexation is used for synergistically introducing Ni and Mo, in-situ vulcanization is performed after inert atmosphere pretreatment, and a dispersed nickel molybdenum sulfide active phase and shallow and deep double-peak metal distribution are obtained. The structure inhibits excessive hydrogenation while ensuring diffusion and structural stability, promotes a direct desulfurization path, and shows high conversion and high selectivity to 4, 6-dimethyl dibenzothiophene. The catalyst has low hydrogen consumption, high aromatic hydrocarbon retention and cycling stability, and is suitable for deep desulfurization of diesel oil and preparation of ultralow-sulfur fuel.

The invention belongs to the technical field of photocatalyst synthesis, and particularly relates to a benzothiophene-naphthalimide covalent organic framework as well as a preparation method and application thereof. A benzothiophene-naphthalimide covalent organic framework (named as SF-COF, formula I) which is novel in structure and relatively high in photocatalytic activity is obtained by assembling a compound with a naphthalimide and benzotrithiophene core framework into a molecule, and the SF-COF is applied to photocatalytic synthesis of polysubstituted olefins.

The invention discloses a hydrodesulfurization catalyst as well as a preparation method and application thereof. The catalyst comprises a carrier, an organic hydrogenation active metal compound and an organic sulfur-containing compound, wherein the organic sulfur-containing compound is selected from at least one of benzothiophene sulfur-containing compounds, dibenzothiophene sulfur-containing compounds or naphthothiophene sulfur-containing compounds containing substituent groups and / or functional groups. The preparation method of the hydrodesulfurization catalyst comprises the following steps: preparing an impregnation liquid containing an organic sulfur-containing compound and an organic hydrogenation active metal compound; and impregnating a carrier with the impregnation liquid, and drying to obtain the catalyst. The catalyst is used in the hydrodesulfurization process of distillate oil, and the deep hydrodesulfurization activity can be obviously improved.

The invention relates to the technical field of waterproof coatings, in particular to a photo-initiation cold coating type non-curing rubber asphalt waterproof coating and a preparation method thereof, and the photo-initiation cold coating type non-curing rubber asphalt waterproof coating comprises an asphalt-based main material, a photo-curing agent and epoxy resin; the light curing agent is composed of a photoinitiator, a rubber monomer and a hindered amine light stabilizer, and the photoinitiator comprises a benzothiophene compound; the waterproof coating is in a single-component paste state, can be constructed at normal temperature, and is cured to form a waterproof coating film after being irradiated by ultraviolet rays; according to the technical scheme, a cross-linking system of the light curing agent and the epoxy resin not only keeps the creep deformation and self-healing characteristics of non-cured rubber asphalt, but also improves the heat resistance, acid, alkali and salt resistance and bonding performance of a coating film through a three-dimensional network cross-linking structure, and it is ensured that a waterproof layer adapts to building structure deformation and severe environments for a long time.

The application discloses a benzothiophenone derivative, a preparation method and application thereof. The benzothiophenone derivative, a tautomer, an optical isomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and the chemical structure of the benzothiophenone derivative is shown as formula (I), wherein R is any one of the following groups: a substituted alkane and N-benzyl-2-chloroformamide. The benzothiophenone derivative can regulate a PPARγ target as an anti-type 2 diabetes drug, can reserve insulin sensitivity, can avoid related side effects caused by a PPARγ full agonist, and has a 'highly efficient and safe' hypoglycemic effect.

The present invention belongs to the field of chemical and pharmaceutical technologies. Disclosed in the present invention are a benzothiophene deuterated compound and the use thereof. The benzothiophene deuterated compound as represented by formula I provided by the present invention can be used as an NLRP3 inhibitor, has high activity and excellent pharmacokinetic properties, and provides a new path for treating NLRP3-related diseases.

The invention provides an application of N-(3-cyano-tetrahydro-1-benzothiophene-2-yl)-2-(morpholine-4-yl) acetamide in the treatment of an Alzheimer's disease. The CN-0928 compound and the analogue CN-0929 of the CN-0928 compound can be used for reducing BACE1 protein expression by regulating and controlling a biomolecular aggregate, so that the A beta plaque load is reduced; in addition, mitochondrial structure change can be recovered, so that AD pathology is further relieved. The treatment based on the intracellular RNPs particles provides a new thought for developing drugs for preventing or treating neurological diseases such as Alzheimer's disease and the like.

The invention relates to the technical field of organic chemistry, in particular to a method for synthesizing a benzothiophene coupling product through a non-metal-participated anchoring-migration strategy. The method comprises the following steps: taking a benzothiophene compound or a benzothiophene sulfoxide compound as a reaction substrate, mixing the reaction substrate with an aryl nucleophilic reagent in the presence of an anhydride activator and a solvent, and carrying out nucleophilic substitution reaction to obtain benzothiophene sulfonium salt; the preparation method comprises the following steps: mixing benzothiophene sulfonium salt with an organic solvent, and carrying out metal-catalysis-free intramolecular migration reaction to form a carbon-carbon bond at the C2 site of benzothiophene, thereby obtaining the benzothiophene coupling product. The preparation conditions are mild, the operation is simple and convenient, a traditional oxidation addition-reduction elimination process is replaced by an anchoring-migration strategy, protection of a noble metal catalyst, a complex ligand, strong base or inert gas is not needed, and the problems of high cost, metal residues, harsh reaction conditions and limited substrate applicability in the prior art are fundamentally solved.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The present invention relates to materials for organic electroluminescent devices. In particular, the present invention relates to amines having dibenzofuran, dibenzothiophene and fluorene groups for use as triplet matrix materials, in particular in organic electroluminescent devices. The invention also relates to a method for producing the compounds according to the invention and to electronic devices comprising said compounds.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

This invention provides an organic electroluminescent device. The organic electroluminescent device comprises a first compound having the structure shown in Formula I and a second compound having the structure shown in Formula II, wherein the first compound is a polysubstituted benzodiazole structure, and the second compound is an amine compound having a benzofuran group, a benzothiophene group, a carbazole group, or a fluorene group. This invention provides that the first and second compounds have better structural matching, better hole injection capability, and excellent charge generation capability. Combining the first and second compounds to prepare the organic electroluminescent device can reduce the device voltage, improve device efficiency, and extend device lifespan.

The invention belongs to the technical field of photosensitizers, and provides a near-infrared iridium complex, a preparation method thereof and application of the near-infrared iridium complex in preparation of a photodynamic therapy preparation. According to the near-infrared iridium complex, 1-(benzo [b] thiophene-2-yl) isoquinoline-4-formonitrile is introduced, and the introduction of cyano groups can significantly reduce an energy gap, so that the iridium complex emits red shift, and the tissue penetrating power is improved; meanwhile, a 2-(3, 5-dimethoxyphenyl)-1-phenyl-1H-imidazo [4, 5-f] [1, 10] phenanthroline ring structure is combined, and a 2-dimethoxyphenyl electron donating group is introduced, so that charge transfer of the near-infrared iridium complex is effectively promoted, the triplet-state service life of the complex is prolonged, and the capability of generating reactive oxygen species (ROS) of the near-infrared iridium complex can be effectively improved. The maximum absorption wavelength of the near-infrared iridium complex is 544 nm, the maximum emission wavelength of the near-infrared iridium complex is 720 nm, and the limitation of tissue penetration can be effectively overcome.

An organic compound that easily exhibits thermally activated delayed fluorescence (TADF) is provided. An organic compound represented by General Formula (G1) is provided. In General Formula (G1), R1 to R8 are each independently any one of hydrogen, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, and a substituted or unsubstituted diarylamino group; at least one of R1 to R8 is a substituted or unsubstituted diarylamino group; α is a substituted or unsubstituted phenylene group; n is an integer of 0 to 4; and A represents a substituted or unsubstituted benzofuropyrimidine skeleton or benzothienopyrimidine skeleton.

The present application relates to a kind of big condensed ring organic compound, belong to organic light-emitting material technical field, simultaneously relate to the application of this kind of compound and the organic electroluminescent device comprising it.The organic compound of the present application has the structure shown as formula (1).The compound of the present application takes indolobenzofuran or indolobenzothiophene as parent nucleus and contains arylamine structure, such compound has good transport performance and stability, when being applied to organic electroluminescent device, it is suitable to be used as light-emitting host material, can effectively improve the service life of device.

The application discloses a preparation method of a supported high-dispersion molybdenum phosphide catalyst, and comprises the following steps: S1, dissolving molybdenum acetylacetonate and ammonium hypophosphite in an aqueous solution of N,N-dimethylformamide to obtain an impregnation solution; S2, immersing a carrier in the impregnation solution, then drying and reducing to obtain a supported molybdenum phosphide catalyst. The hydrogenation activity and the hydrodesulfurization activity of the prepared molybdenum phosphide catalyst are higher than those of MoP catalysts prepared by a temperature programmed reduction method and a molybdenum trioxide reduction method with ammonium hypophosphite, and the molybdenum phosphide catalyst has very high hydrodesulfurization activity on p-benzothiophene.

The invention discloses an efficient synthesis method of brexpiprazole, which comprises the following steps: taking 4-bromo-benzothiophene and N-Boc-piperazine as initial raw materials, under the protection of nitrogen, carrying out reaction by using a supported catalyst to prepare 4-Boc piperazine benzothiophene, and then carrying out acidolysis to obtain 4-piperazine benzothiophene hydrochloride; the method comprises the following steps: reacting 3, 4-dihydro-7-hydroxy-2 (1H) quinolinone with 1-bromo-4-chloro-butane to generate 3, 4-dihydro-7-(4-chlorobutoxy)-2 (1H)-quinolinone, and then converting the 3, 4-dihydro-7-(4-chlorobutoxy)-2 (1H)-quinolinone into 7-(4-chlorobutoxy)-2 (1H)-quinolinone; then condensing with 4-piperazine benzothiophene hydrochloride to obtain a crude product of brexpiprazole; and finally, crystallizing and purifying for multiple times to obtain high-purity brexpiprazole. According to the preparation method disclosed by the invention, 4-bromo-benzothiophene and N-Boc-piperazine are taken as starting raw materials, and high-purity brexpiprazole is prepared by optimizing selection of a catalyst and conditions of each step and through an excellent purification process.

The invention discloses a sulfur-modified defect-containing metal organic framework catalyst and a preparation method and application thereof in pharmaceutical wastewater treatment, and the method comprises the following steps: dissolving 2, 6-naphthalic acid, benzothiophene-2-carboxylic acid and ferric nitrate nonahydrate in a solvent under the conditions of normal pressure and air, mixing, heating for condensation reaction, filtering, washing, and drying to obtain the sulfur-modified defect-containing metal organic framework catalyst. A defect structure is introduced through benzothiophene-2-carboxylic acid, and the sulfur modified metal organic framework catalyst containing defects is generated. According to the invention, MOF with iron as a central metal is adopted, defects are introduced into a structure through modification of benzothiophene-2-carboxylic acid to cause vacancy generation, and active sites are provided through construction of a defect structure, so that the adsorption capacity to pollutants is improved, better catalytic performance is shown, and the application prospect is broad. The photocatalyst has a good application prospect in adsorption-photocatalytic degradation of antibiotic pollutants.

The invention relates to application of raloxifene hydrochloride in preparation of a population effect inhibitor. The invention verifies that the raloxifene hydrochloride can inhibit the population effect of bacteria through a violaceum violaceum luminescence method, and further proves that the raloxifene hydrochloride can inhibit the population effect of pseudomonas aeruginosa and the generation of virulence factors through the inhibition of biological back membrane formation and the inhibition effect of virulence factor generation. The compound is expected to be developed into a clinically available group effect inhibitor, and has an important research value for solving the problems of bacterial infection and drug resistance.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of brexpiprazole. The preparation method comprises the following steps: by taking a compound 4-amino benzo [b] thiophene and chloroacetaldehyde as starting materials, carrying out substitution reaction to prepare an intermediate 2, 2 '-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde, and then carrying out reductive amination reaction on the intermediate 2, 2'-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde and 7-(4-amino butoxy) quinoline-2 (1H)-ketone to construct a piperazine ring, thereby preparing the target product bupremizole I, the product obtained by the process has high yield and purity, and is suitable for industrial production.

The large-scale artificial synaptic device arrays based on the organic molecule-nanowire heterojunctions with tunable photoconductivity are proposed and demonstrated. The organic thin films of p-type 2,7-dioctyl[1]benzothieno[3,2-b][1] benzothiophene (C8-BTBT) or n-type phenyl-C61-butyric acid methyl ester (PC61BM) are used to wrap the InGaAs nanowire parallel arrays to configure two different type-I heterojunctions, respectively. Due to the difference in carrier injection, persistent negative photoconductivity (NPC) or positive photoconductivity (PPC) are achieved in these heterojunctions. The irradiation with different wavelengths (solar-blind to visible ranges) can stimulate the heterojunction devices, effectively mimicking the synaptic behaviors with two different photoconductivities. Evidently, these photosynaptic devices are illustrated with retina-like behaviors and capabilities for large-area integration, which reveals their promising potential for artificial visual systems.

The invention relates to a synthesis process for co-production of p-hydroxyanisole and o-hydroxyanisole, anisole and hydrogen peroxide are used as raw materials, and under the action of a catalyst and an auxiliary agent, the content of p-hydroxyanisole and o-hydroxyanisole can be adjusted. The additive is prepared by taking benzothiophene as a raw material through alkyl ether, ethynylation and ring closing reaction, has certain solvent effect and limiting effect, and can change the proportion of p-hydroxyanisole to o-hydroxyanisole in a product.

This invention belongs to the field of catalyst materials technology, specifically disclosing a class of donor-acceptor polymer photocatalysts, their preparation methods, and their applications in the recycling of spent lithium-ion batteries. This invention provides a class of donor-acceptor polymer photocatalysts, including D1-A-D1-D2 type polymer TFP and D-A1-D-A2 type polymer TSP. Polymer TFP / TSP is synthesized through a Schiff base reaction of 4,4'-(thiazolium[5,4-d]thiazolium-2,5-diyl)dibenzaldehyde with 2,7-diaminofluorene / 3,7-diaminodibenzo[b,d]thiophene-5,5-dioxide. Furthermore, polymer TSP can efficiently photocatalyze the synthesis of H2O2 in a water-benzyl alcohol system. The generated H2O2 enables the recovery of valuable heavy metals (Co, Li) from lithium-ion batteries at room temperature and pressure, providing an important safety guarantee for solving the "environmental pollution pain point" of spent batteries and the sustainable development of the new energy industry.

A polycyclic aromatic compound according to the present invention has a structure composed of one or two or more structural units represented by formula (1). In the polycyclic aromatic compound of the present invention, a carbazole ring and a benzofuran ring or benzothiophene ring represented by formula (b) and the like are fused on a central parent skeleton containing Y1 (for example, B) and nitrogen (N) in formula (1), and at least one of RNY1 to RNY3 has a group represented by formula (a).

This invention discloses a method for preparing raloxifene EP impurity B, comprising the following steps: dissolving 6-methoxy-2-(4-methoxyphenyl)benzothiophene (Ⅰ) as a raw material in solvent one, adding NIS, and then adding a free radical initiator to react and obtain intermediate III; dissolving 4-[2-(1-pyrrolidinyl)ethoxy]benzoate salt (II) in solvent two, adding solvent two or not, and then adding a chlorinating agent to react and generate intermediate IV; dissolving intermediate III in solvent three, adding a Lewis acid, and then adding intermediate IV, and performing a Friedel-Crafts acylation reaction to generate intermediate V; dissolving intermediate V in solvent four, adding a demethylating agent, and generating bisphenol hydroxyl intermediate VI under demethylation conditions; dissolving intermediate VI in solvent five, adding a reducing agent, and generating intermediate VII through a reduction reaction; dissolving intermediate VII in formic acid, stirring, evaporating, and finally lyophilizing to generate the formate target product VIII.

The invention relates to a method for preparing benzothiophene, benzophosphino-role and indene ketene derivatives with high selectivity. The method comprises the following steps: forming benzotitano-role from an aryl Grignard reagent, titanate, cobalt salt, a ligand and alkyne under the action of a deprotonation reagent; and reacting with a sulfur-containing dichloro compound, a phosphine-containing dichloro compound or carbonic ester in situ to respectively obtain a benzothiophene derivative, a benzo phosphino role derivative and an indene ketene derivative. The preparation method has the advantages that the benzothiophene derivative, the benzo phosphino-role derivative and the indene ketene derivative can be prepared by a one-pot method with high selectivity; the catalyst system is simple and cheap; the reaction conditions are mild, various sensitive functional groups are tolerated, and the regioselectivity is high. The method disclosed by the invention is a novel universal preparation method, can be used for preparing different products from the same main raw materials, and is wide in application range and easy to amplify.

The application discloses a ceramic paint for metal doors and a preparation method thereof, and relates to the technical field of paints. The ceramic paint prepared by the application contains sodium silicate, methyltrimethoxysilane, modified polyacrylate emulsion, modified silicon dioxide, glass powder, sodium fluorosilicate, dispersant, leveling agent and pure water. The modified polyacrylate emulsion is obtained by polymerizing phosphorus-containing monomers and vinyl monomers to generate polyacrylate, reacting the polyacrylate with 5-chloromethyl-2-pyrimidine amine after sulfonyl chlorination, and then emulsifying. The silicon dioxide is obtained by polymerizing aniline on the surface of pretreated silicon dioxide, reacting with 1-benzothiophene-5-carbonyl chloride, then salifying with diphenyl iodonium triflate and copper acetate, and then reacting with bis(2-ethynylphenyl) sulfane. The ceramic paint prepared by the application has good corrosion resistance, antibacterial property and anti-aging property, and greatly improves the performance of the metal door.