113 results about "Benzothiophene" patented technology

The invention belongs to the technical field of organic dye synthesis and application, and discloses a conjugated compound containing a benzothiophenazine structure as well as a preparation method and application thereof, and the conjugated compound containing the benzothiophenazine structure has excellent photophysical properties, singlet oxygen yield and superoxide anion generation capacity. The novel conjugated compounds ENBO-NI and ENBS-NI containing benzothiophenazine structures are successfully prepared by replacing a benzene ring of Nile blue with a cycloalkane structure and adjusting the electron donating ability of an R1 group. The two compounds have near infrared fluorescence emission, good solubility and relatively high ROS yield. Compared with a classical photosensitizer NB, the singlet oxygen yield of ENBO-NI is increased by about 117.65%, and the singlet oxygen yield of ENBS-NI is as high as 70%. The absorption wavelength of the conjugated compound is in a red light wave band. The preparation process is simple and efficient, large-scale production is easy, and the preparation method has a wide clinical application prospect.

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

The invention belongs to the technical field of photocatalyst synthesis, and particularly relates to a benzothiophene-naphthalimide covalent organic framework as well as a preparation method and application thereof. A benzothiophene-naphthalimide covalent organic framework (named as SF-COF, formula I) which is novel in structure and relatively high in photocatalytic activity is obtained by assembling a compound with a naphthalimide and benzotrithiophene core framework into a molecule, and the SF-COF is applied to photocatalytic synthesis of polysubstituted olefins.

The invention relates to the technical field of waterproof coatings, in particular to a photo-initiation cold coating type non-curing rubber asphalt waterproof coating and a preparation method thereof, and the photo-initiation cold coating type non-curing rubber asphalt waterproof coating comprises an asphalt-based main material, a photo-curing agent and epoxy resin; the light curing agent is composed of a photoinitiator, a rubber monomer and a hindered amine light stabilizer, and the photoinitiator comprises a benzothiophene compound; the waterproof coating is in a single-component paste state, can be constructed at normal temperature, and is cured to form a waterproof coating film after being irradiated by ultraviolet rays; according to the technical scheme, a cross-linking system of the light curing agent and the epoxy resin not only keeps the creep deformation and self-healing characteristics of non-cured rubber asphalt, but also improves the heat resistance, acid, alkali and salt resistance and bonding performance of a coating film through a three-dimensional network cross-linking structure, and it is ensured that a waterproof layer adapts to building structure deformation and severe environments for a long time.

The present invention belongs to the field of chemical and pharmaceutical technologies. Disclosed in the present invention are a benzothiophene deuterated compound and the use thereof. The benzothiophene deuterated compound as represented by formula I provided by the present invention can be used as an NLRP3 inhibitor, has high activity and excellent pharmacokinetic properties, and provides a new path for treating NLRP3-related diseases.

The invention relates to the technical field of organic chemistry, in particular to a method for synthesizing a benzothiophene coupling product through a non-metal-participated anchoring-migration strategy. The method comprises the following steps: taking a benzothiophene compound or a benzothiophene sulfoxide compound as a reaction substrate, mixing the reaction substrate with an aryl nucleophilic reagent in the presence of an anhydride activator and a solvent, and carrying out nucleophilic substitution reaction to obtain benzothiophene sulfonium salt; the preparation method comprises the following steps: mixing benzothiophene sulfonium salt with an organic solvent, and carrying out metal-catalysis-free intramolecular migration reaction to form a carbon-carbon bond at the C2 site of benzothiophene, thereby obtaining the benzothiophene coupling product. The preparation conditions are mild, the operation is simple and convenient, a traditional oxidation addition-reduction elimination process is replaced by an anchoring-migration strategy, protection of a noble metal catalyst, a complex ligand, strong base or inert gas is not needed, and the problems of high cost, metal residues, harsh reaction conditions and limited substrate applicability in the prior art are fundamentally solved.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The present invention relates to materials for organic electroluminescent devices. In particular, the present invention relates to amines having dibenzofuran, dibenzothiophene and fluorene groups for use as triplet matrix materials, in particular in organic electroluminescent devices. The invention also relates to a method for producing the compounds according to the invention and to electronic devices comprising said compounds.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

This invention provides an organic electroluminescent device. The organic electroluminescent device comprises a first compound having the structure shown in Formula I and a second compound having the structure shown in Formula II, wherein the first compound is a polysubstituted benzodiazole structure, and the second compound is an amine compound having a benzofuran group, a benzothiophene group, a carbazole group, or a fluorene group. This invention provides that the first and second compounds have better structural matching, better hole injection capability, and excellent charge generation capability. Combining the first and second compounds to prepare the organic electroluminescent device can reduce the device voltage, improve device efficiency, and extend device lifespan.

An organic compound that easily exhibits thermally activated delayed fluorescence (TADF) is provided. An organic compound represented by General Formula (G1) is provided. In General Formula (G1), R1 to R8 are each independently any one of hydrogen, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, and a substituted or unsubstituted diarylamino group; at least one of R1 to R8 is a substituted or unsubstituted diarylamino group; α is a substituted or unsubstituted phenylene group; n is an integer of 0 to 4; and A represents a substituted or unsubstituted benzofuropyrimidine skeleton or benzothienopyrimidine skeleton.

The present application relates to a kind of big condensed ring organic compound, belong to organic light-emitting material technical field, simultaneously relate to the application of this kind of compound and the organic electroluminescent device comprising it.The organic compound of the present application has the structure shown as formula (1).The compound of the present application takes indolobenzofuran or indolobenzothiophene as parent nucleus and contains arylamine structure, such compound has good transport performance and stability, when being applied to organic electroluminescent device, it is suitable to be used as light-emitting host material, can effectively improve the service life of device.

The application discloses a preparation method of a supported high-dispersion molybdenum phosphide catalyst, and comprises the following steps: S1, dissolving molybdenum acetylacetonate and ammonium hypophosphite in an aqueous solution of N,N-dimethylformamide to obtain an impregnation solution; S2, immersing a carrier in the impregnation solution, then drying and reducing to obtain a supported molybdenum phosphide catalyst. The hydrogenation activity and the hydrodesulfurization activity of the prepared molybdenum phosphide catalyst are higher than those of MoP catalysts prepared by a temperature programmed reduction method and a molybdenum trioxide reduction method with ammonium hypophosphite, and the molybdenum phosphide catalyst has very high hydrodesulfurization activity on p-benzothiophene.

The invention discloses an efficient synthesis method of brexpiprazole, which comprises the following steps: taking 4-bromo-benzothiophene and N-Boc-piperazine as initial raw materials, under the protection of nitrogen, carrying out reaction by using a supported catalyst to prepare 4-Boc piperazine benzothiophene, and then carrying out acidolysis to obtain 4-piperazine benzothiophene hydrochloride; the method comprises the following steps: reacting 3, 4-dihydro-7-hydroxy-2 (1H) quinolinone with 1-bromo-4-chloro-butane to generate 3, 4-dihydro-7-(4-chlorobutoxy)-2 (1H)-quinolinone, and then converting the 3, 4-dihydro-7-(4-chlorobutoxy)-2 (1H)-quinolinone into 7-(4-chlorobutoxy)-2 (1H)-quinolinone; then condensing with 4-piperazine benzothiophene hydrochloride to obtain a crude product of brexpiprazole; and finally, crystallizing and purifying for multiple times to obtain high-purity brexpiprazole. According to the preparation method disclosed by the invention, 4-bromo-benzothiophene and N-Boc-piperazine are taken as starting raw materials, and high-purity brexpiprazole is prepared by optimizing selection of a catalyst and conditions of each step and through an excellent purification process.

The invention discloses a sulfur-modified defect-containing metal organic framework catalyst and a preparation method and application thereof in pharmaceutical wastewater treatment, and the method comprises the following steps: dissolving 2, 6-naphthalic acid, benzothiophene-2-carboxylic acid and ferric nitrate nonahydrate in a solvent under the conditions of normal pressure and air, mixing, heating for condensation reaction, filtering, washing, and drying to obtain the sulfur-modified defect-containing metal organic framework catalyst. A defect structure is introduced through benzothiophene-2-carboxylic acid, and the sulfur modified metal organic framework catalyst containing defects is generated. According to the invention, MOF with iron as a central metal is adopted, defects are introduced into a structure through modification of benzothiophene-2-carboxylic acid to cause vacancy generation, and active sites are provided through construction of a defect structure, so that the adsorption capacity to pollutants is improved, better catalytic performance is shown, and the application prospect is broad. The photocatalyst has a good application prospect in adsorption-photocatalytic degradation of antibiotic pollutants.

The invention relates to application of raloxifene hydrochloride in preparation of a population effect inhibitor. The invention verifies that the raloxifene hydrochloride can inhibit the population effect of bacteria through a violaceum violaceum luminescence method, and further proves that the raloxifene hydrochloride can inhibit the population effect of pseudomonas aeruginosa and the generation of virulence factors through the inhibition of biological back membrane formation and the inhibition effect of virulence factor generation. The compound is expected to be developed into a clinically available group effect inhibitor, and has an important research value for solving the problems of bacterial infection and drug resistance.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of brexpiprazole. The preparation method comprises the following steps: by taking a compound 4-amino benzo [b] thiophene and chloroacetaldehyde as starting materials, carrying out substitution reaction to prepare an intermediate 2, 2 '-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde, and then carrying out reductive amination reaction on the intermediate 2, 2'-(benzo [b] thiophene-4-yl azane diyl) diacetaldehyde and 7-(4-amino butoxy) quinoline-2 (1H)-ketone to construct a piperazine ring, thereby preparing the target product bupremizole I, the product obtained by the process has high yield and purity, and is suitable for industrial production.

The invention relates to a synthesis process for co-production of p-hydroxyanisole and o-hydroxyanisole, anisole and hydrogen peroxide are used as raw materials, and under the action of a catalyst and an auxiliary agent, the content of p-hydroxyanisole and o-hydroxyanisole can be adjusted. The additive is prepared by taking benzothiophene as a raw material through alkyl ether, ethynylation and ring closing reaction, has certain solvent effect and limiting effect, and can change the proportion of p-hydroxyanisole to o-hydroxyanisole in a product.

This invention belongs to the field of catalyst materials technology, specifically disclosing a class of donor-acceptor polymer photocatalysts, their preparation methods, and their applications in the recycling of spent lithium-ion batteries. This invention provides a class of donor-acceptor polymer photocatalysts, including D1-A-D1-D2 type polymer TFP and D-A1-D-A2 type polymer TSP. Polymer TFP / TSP is synthesized through a Schiff base reaction of 4,4'-(thiazolium[5,4-d]thiazolium-2,5-diyl)dibenzaldehyde with 2,7-diaminofluorene / 3,7-diaminodibenzo[b,d]thiophene-5,5-dioxide. Furthermore, polymer TSP can efficiently photocatalyze the synthesis of H2O2 in a water-benzyl alcohol system. The generated H2O2 enables the recovery of valuable heavy metals (Co, Li) from lithium-ion batteries at room temperature and pressure, providing an important safety guarantee for solving the "environmental pollution pain point" of spent batteries and the sustainable development of the new energy industry.

A polycyclic aromatic compound according to the present invention has a structure composed of one or two or more structural units represented by formula (1). In the polycyclic aromatic compound of the present invention, a carbazole ring and a benzofuran ring or benzothiophene ring represented by formula (b) and the like are fused on a central parent skeleton containing Y1 (for example, B) and nitrogen (N) in formula (1), and at least one of RNY1 to RNY3 has a group represented by formula (a).

This invention discloses a method for preparing raloxifene EP impurity B, comprising the following steps: dissolving 6-methoxy-2-(4-methoxyphenyl)benzothiophene (Ⅰ) as a raw material in solvent one, adding NIS, and then adding a free radical initiator to react and obtain intermediate III; dissolving 4-[2-(1-pyrrolidinyl)ethoxy]benzoate salt (II) in solvent two, adding solvent two or not, and then adding a chlorinating agent to react and generate intermediate IV; dissolving intermediate III in solvent three, adding a Lewis acid, and then adding intermediate IV, and performing a Friedel-Crafts acylation reaction to generate intermediate V; dissolving intermediate V in solvent four, adding a demethylating agent, and generating bisphenol hydroxyl intermediate VI under demethylation conditions; dissolving intermediate VI in solvent five, adding a reducing agent, and generating intermediate VII through a reduction reaction; dissolving intermediate VII in formic acid, stirring, evaporating, and finally lyophilizing to generate the formate target product VIII.

The invention discloses a copper-catalyzed aryl aldehyde ortho-position direct C-H etherification method, which comprises the following steps: by taking aryl aldehyde as a raw material, adding alcohol or phenol as shown in a formula (II), a copper catalyst, a guiding group, alkali and a solvent into a reactor, and reacting in an argon gas atmosphere to prepare an aryl ether compound as shown in a formula (III), a substituent group R1 is hydrogen, methyl, trifluoromethyl, methoxyl, phenyl, iodo, isopropyl, trimethylsilyl, dimethylamino, fluoro, chlorine, ester, tourmaline, naphthyl, isoquinolyl, benzothienyl or phenanthryl; a substituent group R2 is hydrogen, methyl, trifluoromethyl, methoxyl, phenyl, iodo, isopropyl, trimethylsilyl, dimethylamino, fluoro, chlorine, ester, tourmaline, naphthyl, isoquinolyl, benzothienyl or phenanthryl; and a substituent group R2 is methyl, 4-fluorophenyl, cyclobutane methyl, 4-tert-butyl phenyl, pentafluorophenyl, 4-cyanophenyl, 4-methyl ester phenyl, 3-nitrophenyl, adamantane methyl, cyclohexyl or an oestrone analogue. The copper catalyst and amino acid which are low in cost and easy to obtain are used as guiding groups, the operation process is simple and efficient, and the corresponding aryl ether compound can be obtained with the good yield.

The invention discloses a benzothiophene ROCK2 inhibitor as well as a preparation method and application thereof. The invention provides a benzothiophene derivative which is novel in structure and has ROCK2 kinase inhibition activity. Tests prove that the compounds provided by the invention all show relatively high activity, the prepared compounds have good ROCK2 inhibitory activity, and particularly, ROCK2 / ROCK1 selectivity is higher than that of a positive drug KD025. The ROCK2 inhibitor is a benzothiophene derivative, can be used for treating diseases or symptoms related to ROCK2 activity, and can be used for preparing anti-tumor / tumor immunity enhancing and / or anti-inflammatory drugs for treating and preventing tumors and / or inflammations. In addition, the invention also provides a method for preparing the benzothiophene derivative, and the method has the advantages of short synthetic route, simple preparation process and easy operation, and can meet the needs of large-scale industrial production.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of brexpiprazole. The preparation method comprises the following steps: taking compounds 4-amino benzo [b] thiophene and chloroacetaldehyde as starting materials, firstly carrying out reductive amination disubstitution reaction to prepare an intermediate N, N-bis (2-chloroethyl) benzo [b] thiophene-4-amine, then carrying out substitution reaction on the intermediate N, N-bis (2-chloroethyl) benzo [b] thiophene-4-amine and 7-(4-amino butoxy) quinoline-2 (1H)-ketone to construct a piperazine ring to prepare the target product brexpiprazole. The product obtained by the process has high yield and purity, and is suitable for industrial production.

This invention provides a method for preparing 2-alkylthiobenzo[b]thiophene sulfone compounds. Using acylsulfonylmethylthio ylide compounds as raw materials, cyclization in the presence of an acid anhydride or acyl halide is induced to achieve the preparation of 2-alkylthiobenzo[b]thiophene sulfone compounds. This preparation method uses readily available and simple raw materials and is easy to operate. The obtained compounds can be applied to important organic materials, such as luminescent materials, antibacterial and anticancer drugs, and pesticides. They can also be used as intermediates in the synthesis of organic materials and drugs, and for the preparation of various materials and drugs.

The invention relates to a method for preparing 2-aryl-3-difluoromethyl benzothiophene by utilizing an electrochemical reaction. Specifically, the invention provides an electrochemical anodic oxidation cathode reduction characteristic instead of a traditional chemical oxidation reducing agent, sodium difluoromethanesulfinate is used as a difluoromethyl donor, and a difluoromethyl free radical is excited through electrochemical anodic oxidation, so that the difluoromethyl free radical is synthesized. The preparation of the target molecule 2-aryl-3-difluoromethyl benzothiophene is realized through intramolecular cyclization initiated by addition of free radicals to active alkyne. The method does not need to add an additional transition metal catalyst and a super-stoichiometric redox agent, has the advantages of mild reaction conditions, high product yield, good chemical selectivity and the like, better conforms to the purpose of green and sustainable development of the current society, and has a good industrial application prospect.

The invention belongs to the technical field of medicine synthesis, and particularly relates to an efficient synthesis method of brexpiprazole. The invention provides a novel preparation method of bupreprazole, which comprises the following steps: by taking 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine as a starting material, carrying out substitution reaction on the 1-(benzo [b] thiophene-4-yl)-4-(4-bromobutyl) piperazine and 7-hydroxy-2H-benzopyran-2-ketone to prepare an intermediate 7-(4-(4-(benzo [b] thiophene-4-yl) piperazin-1-yl) butoxy)-2H-benzopyran-2-ketone; according to the present invention, with the process, the use of the noble metal catalyst and the generation of the related dimer and the heterotopic substitution impurity can be effectively avoided, and the product obtained through the process has characteristics of high yield and high purity, and is suitable for industrial production.

This invention relates to conjugated polymers containing dibenzofuran (thiophene) and carbazole units, their preparation methods, and applications. To address the problems of poor optical contrast, slow response time, and poor cycling stability of existing conjugated polymers as electrochromic materials, this invention uses 2,8-dibromodibenzofuran or 2,8-dibromodibenzothiophene as reactants, reacting them with 9-hexyl-3,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxoborane-2-yl)-carbazole or 9-phenyl-3,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxoborane-2-yl)-carbazole to form conjugated polymers with dibenzofuran (thiophene) and carbazole units in the main chain. The conjugated polymers of this invention exhibit excellent electrochromic properties, including excellent cycling stability, fast switching time, high optical contrast, and low voltage start-up. This invention is expected to be applied in fields such as smart windows, rearview mirrors, military camouflage, and electronic tags in the construction and automotive industries.

The present application relates to novel compounds of formula (I) which are prodrugs of brexpiprazole. The novel compounds of the invention, upon administration to a subject, undergo chemical conversion by one or more metabolic processes to release an active pharmacological agent in vivo. Brexpiprazole, sold under the Rexulti (registered trademark), is an atypical antipsychotic indicated for use as an adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD) in adults and the treatment of schizophrenia in adults and pediatric patients ages 13 years and older.

A method of determining an API gravity of a crude oil includes obtaining a reservoir sample containing the crude oil, separating an aromatic fraction from the reservoir sample, analyzing the aromatic fraction using a gas chromatography mass spectrometry (GC-MS) instrument, determining peak areas and a ratio of 4-methyldibenzothiophene and 1-methyldibenzothiophene, and determining the API gravity of the crude oil in the reservoir sample using an empirical correlation between API gravity and the ratio of 4-methyldibenzothiophene to 1-methyldibenzothiophene. A method of determining productivity of a region of a reservoir includes determining an API gravity of a crude oil in the sample from the region of the reservoir using an empirical correlation between API gravity and the ratio of 4-methyldibenzothiophene to 1-methyldibenzothiophene, and based on the API gravity of the sample, determining the productivity of the region of the reservoir.