308 results about "Phloroglucinol" patented technology

The invention provides a covalent organic framework material as well as a preparation method and application thereof, and belongs to the technical field of covalent organic framework materials. The method provided by the invention comprises the following steps: mixing 2, 4, 6-triformyl phloroglucinol, multi-element aromatic amine and a polar organic solvent, and sequentially carrying out Schiff base reaction and precipitation to obtain a crude product; the ratio of the volume of the polar organic solvent to the mass of the 2, 4, 6-triformyl phloroglucinol is 300 to 500 mL / g; and sequentially washing and drying the crude product to obtain the covalent organic framework material. The method provided by the invention does not need to be operated under an anhydrous condition, the 2, 4, 6-triformyl phloroglucinol does not need to be completely dissolved in a reaction system, the use amount of an organic solvent can be remarkably reduced, a good reaction effect can be achieved without anhydrous and anaerobic tube sealing, and the method is suitable for large-scale production.

The invention discloses a preparation method of a self-humidifying membrane electrode of a proton exchange membrane fuel cell, relates to a preparation method of a membrane electrode, and aims to solve the technical problem of poor performance of the conventional self-humidifying membrane electrode. The method comprises the following steps: 1, synthesizing a COFs material by using 2, 4, 6-triformyl phloroglucinol and 2, 5-diaminobenzene sulfonic acid through a two-phase method; 2, preparing slurry a by using a Pt / C catalyst and a perfluorosulfonic acid ionomer solution; preparing self-humidifying catalyst layer slurry b from a COFs material, a Pt / C catalyst and a perfluorosulfonic acid ionomer solution; and 3, coating the slurry a on the anode surface of the proton exchange membrane, and coating the slurry b on the cathode surface to obtain the self-humidifying membrane electrode. According to the electrode, H2 / O2 is used as fuel, and the power density is 756.3 mW / cm < 2 > under the relative humidity of 20%; h2 / air is used as fuel, the power density is 437.8-879.7 mW / cm < 2 > under the relative humidity of 50%, and the material can be applied to the field of fuel cells.

The invention relates to an alkynyl-modified acyl covalent organic framework (COF) material and application thereof, and relates to the field of preparation of crystalline porous materials and fuel cells. The material is a covalent organic framework material which is synthesized by taking 1, 3, 5-triformyl phloroglucinol and 2, 5-bis (2-propynyloxy) terephthaloyl hydrazine as raw materials through solvothermal reaction under specific conditions, and has relatively high crystallinity. The material has good performance in the aspect of proton conductivity, the highest proton conductivity can reach 6.16163 * 10 <-4 > S / cm, and the mechanical property is enhanced due to introduction of alkynyl. Alkynyl is used as an active functional group, and various chemical reactions can be derived, so that the potential application value of the material is greatly improved.

The invention relates to the field of oil storage microcapsules, and discloses a porous covalent organic framework oil storage microcapsule as well as a preparation method and application thereof. Under the catalysis of p-toluenesulfonic acid, 4, 4 ', 4' '-(1, 3, 5,-triazine-2, 4, 6-triyl) triphenylamine and trialdehyde phloroglucinol monomers are promoted to be subjected to condensation reaction in the repeated oscillation process, a product is purified to prepare a 4, 4', 4 ''-(1, 3, 5,-triazine-2, 4, 6-triyl) triphenylamine covalent organic framework, and by means of a periodic pore structure of the covalent organic framework, the covalent organic framework can be used for preparing the covalent organic framework. And the lubricating oil is adsorbed and stored and can be controllably separated out to provide lubrication during working, so that a high-performance self-lubricating effect can be realized. In addition, covalent organic frameworks are used as hard particles to be doped into a polymer matrix to modify the polymer matrix, so that the wear resistance of the polymer matrix can be greatly enhanced, and the performance of the self-lubricating bearing material is improved.

The invention discloses a polycyclic polyisopentenyl phloroglucinol compound as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The method comprises the following steps: by taking a dry overground part of hypericum monogynum as a raw material, performing percolation extraction and concentration to obtain an extract, suspending the extract in water to obtain a suspension, and performing extraction and concentration to obtain a petroleum ether part extract; the extract is taken and subjected to separation through a positive and negative phase silica gel column, MCI medium-pressure column chromatography and Sephadex LH-20 gel column chromatography and purification through high performance liquid chromatography, the polycyclic polyisopentenyl phloroglucinol compound is prepared, and the structure and configuration of the compound are determined by means of a spectrum analysis technology, quantum chemistry calculation, X-ray single crystal diffraction and the like. The compound can inhibit TNF-alpha protein to play an immunosuppressive role, and can be used as an immunosuppressive drug.

An artificial synthesis method for malonyl-CoA and use thereof are provided. By means of heterologous expression of an aminotransferase and a malonyl-CoA reductase, an artificial synthesis pathway for synthesizing malonyl-CoA by using β-alanine (β-ala) as a precursor is constructed as follows: firstly, under catalysis of a transaminase, β-ala transfers amino groups to α-ketonic acid (such as pyruvic acid, oxaloacetic acid, or α-ketoglutaric acid, etc.), to form an intermediate product 3-oxopropanoate and a corresponding amino acid; the 3-oxopropanoate generates malonyl-CoA under the action of the malonyl-CoA reductase. This pathway addresses the defects of the natural malonyl-CoA synthesis pathway, such as low carbon utilization, consumption of energy substance ATP, release of greenhouse gas CO2, and strict regulation of pathway enzymes, a pyruvate dehydrogenase (PDH) and an acetyl-CoA carboxylase (ACC), thereby achieving high yielding of products using malonyl-CoA as a precursor, including flaviolin, octanoic acid, phloroglucinol, pentadecaheptaene, natamycin, and spinosad.

The invention provides a covalent organic framework composite membrane as well as a preparation method and application thereof. The preparation method of the covalent organic framework composite membrane comprises the following steps: (1) dissolving 2, 4, 6-triformyl phloroglucinol in an organic solvent to obtain a 2, 4, 6-triformyl phloroglucinol solution; slowly adding a buffer layer of deionized water or alkali liquor to the top of the 2, 4, 6-triformyl phloroglucinol solution; dropwise adding a solution containing a diamine ligand onto the buffer layer, reacting at 25-35 DEG C for 3-10 days, collecting nanosheets, and dialyzing and purifying the nanosheets to obtain the covalent organic framework nanosheets, (2) taking hydroxyl carbon nanotubes, adding an organic solvent, and carrying out ultrasonic dissolution to obtain a hydroxyl carbon nanotube solution; taking a hydroxyl carbon nanotube solution, mixing the hydroxyl carbon nanotube solution with the covalent organic framework nanosheet obtained in the step (1), performing uniform ultrasonic treatment, performing vacuum pressurization, assembling the mixture onto a nylon membrane, and performing drying to obtain the covalent organic framework composite membrane. The membrane material has excellent properties such as relatively high rejection rate and good antifouling property.

The invention provides a rapid visual D-limonene detection method and application thereof, and belongs to the technical field of analytical chemistry, the method comprises the following steps: uniformly mixing ethanol and water to form a solvent system, sequentially adding template agents Pluronic P123 and Pluronic F127, phloroglucinol, 1, 3, 5-trimethylbenzene and ethylenediamine, and uniformly stirring at room temperature; after the reaction is completed, washing, centrifuging, drying and calcining an obtained sample to obtain DNCzyme; the method comprises the following steps: adding TMB, H2O2 and DNCzyme into an acetic acid-sodium acetate buffer solution HAc-NaAc, finally adding D-limonene, incubating, and carrying out visual detection on the solution. The method for detecting the D-limonene through colorimetric sensing is rapid, simple, convenient, low in cost, high in sensitivity and good in selectivity, and visual detection is achieved by combining a smart phone.

The invention relates to the technical field of battery electrodes, in particular to a zinc pole piece coated with a sulfonic COF membrane, a preparation method of the zinc pole piece and an aqueous zinc battery, and the preparation method comprises the following steps: dissolving 2, 4, 6-triformyl phloroglucinol and p-phenylenediamine-2, 5-disulfonic acid in an organic solvent to obtain a mixed solution; and putting the zinc foil into the mixed solution, carrying out sealed standing at normal temperature, taking out the zinc foil coated with the sulfonic group COF film, and washing and drying the zinc foil to obtain the zinc pole piece coated with the sulfonic group COF film. The prepared zinc pole piece coated with the sulfonic COF film has good corrosion resistance and dendritic crystal inhibition capacity, and when the zinc pole piece is used as a negative electrode of a water-based zinc battery, the cycle performance of the water-based zinc battery can be improved, and the cycle life of the water-based zinc battery can be prolonged; the problems that a zinc negative electrode of an existing water-based zinc battery is prone to generating dendritic crystal and corrosion passivation side reactions in the battery circulation process, so that the use performance of the water-based zinc battery is reduced, and the service life is greatly shortened are solved.

The application discloses a preparation method of carbon aerogel material for light electromagnetic shielding, and comprises the following steps: adding resorcinol, phloroglucinol, a template agent and formaldehyde into pure water, stirring and dissolving to obtain a precursor solution; adding the precursor solution into white oil containing a surfactant, emulsifying, heating in an oil bath and fully reacting; centrifugal separation to obtain powder, high-temperature carbonization, dispersion in oleylamine, addition into a stock solution containing nickel acetylacetonate, triphenylphosphine and oleylamine, high-temperature reaction and cooling, addition of a mixture of hexane and ethanol to obtain a product; centrifugal separation and washing to obtain light high-electromagnetic-shielding carbon aerogel. The carbon aerogel material for light electromagnetic shielding prepared by the method has the advantages of small density, high efficiency, corrosion resistance, high electromagnetic shielding efficiency, high product yield and the like, and by controlling the nucleation and growth rate of Ni2P, the Ni2P nanoparticles can be uniformly grown on the carbon aerogel microspheres, and the method is suitable for application in large-scale industrial production.

The invention provides a composite film based on a two-dimensional covalent organic framework as well as a preparation method and application of the composite film. The preparation method comprises the following steps: pouring a 2, 4, 6-triformyl phloroglucinol solution into the bottom layer of a container, slowly dropwise adding deionized water as a buffer solution, and dropwise adding a diamine monomer 2, 5-diaminobenzene sulfonic acid solution on the uppermost layer; under a static condition, carrying out a synthetic reaction at room temperature; after the reaction is finished, sucking out the upper-layer nanosheet by using a suction tube, and filling the upper-layer nanosheet into a treated dialysis bag; the synthesized nanosheet is subjected to dialysis treatment in deionized water, a TpPa-SO3H nanosheet is obtained, and a covalent organic framework nanosheet solution is obtained; taking a carbon nanotube, adding an organic solvent, and carrying out ultrasonic dissolution to obtain a carbon nanotube solution; a carbon nanotube solution and a covalent organic framework nanosheet solution are taken to be mixed and subjected to uniform ultrasonic treatment, the mixture is assembled to a nylon membrane through vacuum pressurization, drying is conducted, and the two-dimensional covalent organic framework composite membrane is obtained and has good performance and can be well applied to seawater desalination or dye separation.

A method of manufacturing a gC3N4-grafte hybrid covalent organic framework is provided. The method includes synthesizing 1,3,5-triformyl phloroglucinol (Tp), p-phenylene diamine (ppd), and gC3N4 to form Tp-ppd-gC3N4-x covalent organic frameworks (COFs), where x represents a weight % (wt %) of gC3N4 with respect to a total weight of aldehyde and amine.

The invention belongs to the field of chemical medicine analysis, and particularly relates to a method for determining the content of impurities in phloroglucinol trimethyl ether. According to the method provided by the invention, the excessive methylation impurities (2, 4, 6-trimethoxytoluene, 2, 4, 6-trimethoxyxylene and 2, 4, 6-trimethoxytrimethylbenzene) generated in the methylation process can be detected, and the excessive methylation impurities are prevented from being further transferred and existing in a phloroglucinol trimethyl ether raw material medicine and a final product phloroglucinol injection preparation. Researches on specificity, accuracy, precision, limit of detection, limit of quantitation, linear range, durability and the like of the method prove that the method is suitable for measuring the content of the over-methylated impurities in the phloroglucinol trimethyl ether.

The present invention relates to bio-based bisphenol monomer of formula I and process of preparation thereof. Specifically, the present invention relates to bio-based bisphenol monomers of formula I containing multiple alkoxyl groups, and polyphenols. The bisphenol monomers of formula I contain built-in methoxyl groups, which represent latent phenolic hydroxyl groups and could conveniently be de-blocked to phenolic hydroxyl groups leading to formation of polyphenols containing catechol / phloroglucinol units with anti-oxidant properties and are potentially useful in various applications like cosmetics, polymer additives and so on. Further, the present invention relates to process of preparation of polymers using bisphenol monomer of formula I as valuable building blocks wherein the high performance thermoplastics are poly(ether sulfone)s, poly(ether ether ketone)s, polyesters, polycarbonates, polyphosphonates, etc. and thermosetting resins are epoxies, cyanate esters, phthalonitriles, propargyl ethers, etc.

The utility model relates to the technical field of medicine processing, in particular to a raw material stirring device for phloroglucinol production, which comprises a mixing tank, a stirring assembly is arranged in the mixing tank and comprises a rotating sleeve, a central stirring rod is mounted below a rotating main shaft, a gear ring is mounted on the outer side of the rotating main shaft, a side stirring rod is rotatably mounted in a side sleeve in a penetrating manner, and a gear is mounted at the top end of the side stirring rod; when a central stirring rod rotates, a central supporting rod is driven to stir raw materials in the mixing tank, when a gear rotates around the central stirring rod, a side stirring rod is driven by the gear to rotate in a side sleeve, and at the moment, the side stirring rods in side stirring assemblies on the two sides drive side supporting rods to rotate around the central stirring rod while rotating around the central stirring rod; and in the gas rising process, raw materials located on the first partition plate can be lifted upwards, the effect of improving the raw material mixing effect is achieved through cooperation, and compared with a traditional raw material stirring device, the raw material mixing speed is higher, and the mixing effect is better.

The invention relates to the field of electric wires and cables, and discloses a high-temperature-oxidation-resistant flame-retardant electric wire and cable and a preparation method thereof.The sheath layer of the electric wire and cable comprises low-density polyethylene, nitrile rubber, natural rubber, ethylene-tetrafluoroethylene copolymer, modified multi-walled carbon nanotubes, modified nano titanium dioxide and auxiliaries; the modified multi-walled carbon nanotube is prepared by reacting an acylating chlorination multi-walled carbon nanotube with a polycyclotriphosphazene derivative; the polycyclotriphosphazene derivative is prepared by reacting hexachlorocyclotriphosphazene with p-aminodiphenylamine and then taking diphenyl dihydroxysilane as a linker; the modified nano titanium dioxide is prepared by the following steps: substituting phenylphosphoryl dichloride with phloroglucinol, then sequentially substituting with 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionyl chloride and 3-aminopropyltriethoxysilane, and grafting an obtained antioxidant phosphorus-containing coupling agent with nano titanium dioxide. The sheath layer material prepared by the invention has excellent high-temperature oxidation resistance, flame retardance, wear resistance and heat resistance.

The invention belongs to the technical field of covalent organic framework membrane materials, and provides a covalent organic framework / polyether sulfone mixed matrix membrane as well as a preparation method and application thereof. The method comprises the following steps: mixing polyether sulfone, a solvent and trialdehyde phloroglucinol to obtain a trialdehyde phloroglucinol solution; the glass fiber filter membrane is coated with the trialdehyde phloroglucinol solution, and a trialdehyde phloroglucinol / polyether sulfone membrane is obtained; the method comprises the following steps: mixing p-phenylenediamine, a catalyst and water to obtain a p-phenylenediamine solution; the trialdehyde phloroglucinol / polyether sulfone membrane is soaked in a p-phenylenediamine solution for a reaction, and the covalent organic framework / polyether sulfone mixed matrix membrane is obtained. The preparation method disclosed by the invention is mild in condition, the obtained membrane is uniform and stable, the advantages of high flux of a polymer and strong adsorption and separation of a covalent organic framework on CO2 are fully combined, and the H2 flux and H2 / CO2 selectivity of the covalent organic framework / polyether sulfone mixed matrix membrane are greatly improved.

The invention provides a dye / ion separation membrane with pore diameter and charge coordinated regulation and control as well as a preparation method and application thereof, and belongs to the field of preparation of a double-layer ionic covalent organic framework (COFs) composite membrane. An aromatic polyamide ultrafiltration membrane is used as a base membrane, and a double-layer COFs membrane is constructed on the surface of the aromatic polyamide ultrafiltration membrane through a multi-time interfacial polymerization method. The first layer is a positive charge COFs layer formed by reacting a guanidyl monomer with 1, 3, 5-triformyl phloroglucinol (Tp); and the second layer is a negative charge COFs layer formed by reacting ionic aromatic diamine with Tp. By adjusting the type and concentration of the monomers, the pore diameter and charge distribution of the film layer can be synergistically regulated and controlled, and the double-layer composite film which is stable in structure and orderly stacked is constructed. The obtained membrane has molecular sieve separation and electrostatic regulation functions, can efficiently intercept organic dye molecules in high-salt printing and dyeing wastewater, and has high flux, high selectivity and good chemical stability.

The invention relates to the technical field of membrane separation, and particularly provides a GO-coated TP-TTTA composite nanofiltration membrane and a preparation method and application thereof.The GO-coated TP-TTTA composite nanofiltration membrane comprises a basement membrane and a graphene oxide membrane formed on the surface of one side of the basement membrane, a porous organic framework material is grown between film layers of the graphene oxide film and on the surface of the graphene oxide film in situ, and the porous organic framework material is a TP-TTTA material obtained by bonding 2, 4, 6-tri (4-aminophenyl)-1, 3, 5-triazine and trialdehyde phloroglucinol through a carbon-carbon double bond. The GO-coated TP-TTTA composite nanofiltration membrane provided by the invention has excellent stability and permeability, the preparation method is simple to operate, and the reaction conditions are low-carbon and environment-friendly.

The invention discloses a chemical-enzyme integrated catalyst for oxygen functionalization reaction of an inert C-H bond. The chemical-enzyme integrated catalyst is obtained by simultaneously fixing a rhodium (III) complex and non-specific peroxygenase AaeUPO by a covalent organic framework (COF) material with a macroporous structure inside, wherein trialdehyde phloroglucinol and 5, 5 '-diamino-2, 2'-dipyridyl are used as ligands, polystyrene spheres are used as hard templates to prepare holes, and a covalent organic framework (COF) material with a macroporous structure is prepared, and is recorded as macro-COF. The chemical-enzyme integrated catalyst provided by the invention not only realizes efficient conversion of in-situ production of hydrogen peroxide to drive AaeUPO to catalyze an inert C-H bond oxygen functionalization reaction, but also can effectively inhibit damage of high-concentration hydrogen peroxide to an AaeUPO active center.

The invention discloses application of zwitterionic covalent organic framework solid-phase microextraction fibers in neurotransmitter analysis, and the zwitterionic covalent organic framework solid-phase microextraction fibers are prepared by taking ethidium bromide, 2, 5-diaminobenzoic acid and trialdehyde phloroglucinol as functional monomers and acetic acid as a catalyst through Schiff base reaction condensation to obtain the zwitterionic covalent organic framework solid-phase microextraction fibers. The ionic covalent organic framework material is obtained. The ionic covalent organic framework solid-phase micro-extraction fiber coating prepared by the invention has good hydrophilicity, and besides, functional groups such as hydroxyl, carboxyl, phenyl and quaternary ammonium which are rich in the structure of the coating can interact with a target analyte through ion exchange action, pi-pi stacking, hydrogen-bond interaction and hydrophilic and hydrophobic interaction; the strong specific adsorption and efficient enrichment capability on neurotransmitters are shown. The ionic covalent organic framework solid-phase microextraction fiber prepared by the invention realizes efficient enrichment and extraction analysis of neurotransmitters with different polarities in a complex biological sample matrix.

The invention discloses a preparation method and application of a nitrogen-containing heterocyclic porous covalent organic framework material. The preparation method comprises the following steps: mixing trialdehyde phloroglucinol and a nitrogen heterocyclic ring-containing monomer according to a certain mass ratio, adding an organic catalyst and a mixed solvent, degassing, sealing, carrying out solvothermal reaction synthesis, washing with a polar solvent, carrying out Soxhlet extraction and purification, and drying to obtain the nitrogen heterocyclic ring-containing porous covalent organic framework material. According to the method, a pyridazine unit and trialdehyde phloroglucinol are used as monomers to construct a COF skeleton of a nitrogen heterocyclic ring, an asymmetric pi-conjugated structure is formed, efficient electron-hole space separation is achieved, active site charge distribution is optimized through the electron-rich characteristic of the pyridazine unit, and the oxygen molecule adsorption and activation capacity is enhanced. The method adopts a green solvent, is mild in reaction condition, avoids the use of toxic reagents, is green and environment-friendly, and provides a new way for photocatalytic synthesis of hydrogen peroxide.

The invention provides a single / double metal atom modified covalent organic framework catalytic material and a preparation method and application thereof, and belongs to the technical field of Fenton-like method wastewater treatment, 1, 3, 5-triformyl phloroglucinol and 2, 2 '-bipyridine-5, 5'-diamine are used for preparing TB-COF, the TB-COF is used for preparing TB-COF, the TB-COF is used for preparing TB-COF, and the TB-COF is used for preparing TB-COF. One or two metals of iron, manganese, cobalt or nickel are modified to obtain the single / double metal atom modified covalent organic framework catalytic material, and the application of the material in treatment of micropollutants in a water body is also provided. The single / double metal atom modified covalent organic framework catalytic material provided by the invention has relatively high reaction activity, is an excellent Fenton-like catalytic active material, can generate various active oxygen species and chlorine dioxide after being in contact with chlorite, has the removal efficiency of more than 75% on various water body micro-pollutants, and can be used as a catalyst for treating water body micro-pollutants. And after multiple cycles, high catalytic activity and good structural integrity can still be maintained.

The invention discloses a polymer solid electrolyte based on a covalent organic framework, and a preparation method and application thereof. According to the method, firstly, PVDF-HFP and PEG1-NH2 are synthesized into a PH-PEG1-NH2 thin film, then a trialdehyde phloroglucinol solution is poured on the thin film to generate a PH-PEGCOF composite film, the composite film is impregnated with PEO and lithium salt to form a polymer electrolyte film, the polymer electrolyte film is applied to a solid-state lithium battery, and the assembled battery has good stable cycle performance.

The invention belongs to the technical field of membrane separation, and particularly relates to a polyamide composite membrane containing amino-carboxyl bifunctional COFs as well as a preparation method and application of the polyamide composite membrane. The preparation method comprises the following steps: by taking 1, 3, 5-tri (4-aminophenyl) benzene, 4, 4 '-diaminobiphenyl-2, 2'-dicarboxylic acid and 1, 3, 5-trialdehyde phloroglucinol as monomers, carrying out solvothermal reaction to prepare a bifunctional COFs material rich in amino groups and carboxyl groups at the same time; the preparation method comprises the following steps: dispersing a COFs material in a water phase containing polyamine, and carrying out interfacial polymerization on the water phase and an oil phase containing polyacyl chloride to prepare the composite membrane. COFs are firmly anchored in a polyamide network through a covalent reaction between amino and an acyl chloride monomer, so that the problems that the COFs are easy to fall off and non-uniform in dispersion are solved; the water flux is improved by regular pore channels of COFs, the membrane is endowed with strong hydrophilicity and electronegativity by carboxyl, the desalination rate and the pollution resistance are remarkably enhanced, and the COFs-based composite membrane has a wide application prospect in seawater desalination and high-salinity wastewater treatment.

The invention relates to the technical field of natural medicines, in particular to a 3 / 6 / 5 / 6 / 5 pentacyclic phloroglucinol compound as well as a preparation method and application thereof. The 3 / 6 / 5 / 6 / 5 pentacyclic phloroglucinol compound disclosed by the invention has a structure as shown in a formula I; the method comprises the following steps: extracting hypericum monogynum by using ethanol and petroleum ether, sequentially eluting the obtained petroleum ether extract through silica gel column chromatography, MCI resin column chromatography, Sephadex LH-20 gel column chromatography and ODS medium-pressure column chromatography, and purifying the collected eluate through preparative ODS liquid chromatography and semi-preparative ODS liquid chromatography to obtain the 3 / 6 / 5 / 6 / 5 pentacyclic phloroglucinol compound. The 3 / 6 / 5 / 6 / 5 pentacyclic phloroglucinol compound is extracted from hypericum monogynum for the first time, and the compound has great development value as a novel medicine for preventing or treating calcified aortic valve diseases.

The invention discloses a high-stability hydrated covalent organic framework membrane which comprises an ionic covalent organic framework and a self-supporting flexible substrate and is prepared by a vacuum-assisted self-assembly method, the thickness of the membrane is less than 100nm, and the pore size of the membrane is 2 + / -0.2 nm; the covalent organic framework is a nanosheet formed by polymerizing an aldehyde monomer 1, 3, 5-triformyl phloroglucinol and an amino monomer 4, 4 '-diamino-3. 3'-biphenyl disulfonic acid through a phase transfer method. According to the application of the membrane in natural gas decarburization, the membrane is applied to a wet natural gas purification system, has high flux and high selectivity in a CO2 / CH4 separation process, can tolerate multi-component conditions such as H2S, heavy hydrocarbons (C2H6, C3H8, n-C4H10, n-C6H14 and the like) and pressure as high as 33 bar, also has excellent separation performance on H2S / CH4, and has excellent separation performance in saturated steam of C6H14, C7H8 and C8H10 (hexane partial pressure is greater than or equal to 20 kPa). And the membrane separation performance is not obviously changed.

The invention provides an application of two polycyclic polyisopentenyl acyl phloroglucinol compounds (PPAP) with different skeleton types in preparation of drugs for relieving / treating neurodegenerative diseases. Belongs to the technical field of medicines. Hypheronone A provided by the invention is a 1, 9-split-ring polycyclic polyisopentenyl phloroglucinol compound, and hypheronone L is a polycyclic polyisopentenyl phloroglucinol compound which is formed by carrying out intramolecular [4 + 2] cyclization on a monocyclic polyisopentenyl phloroglucinol compound and has a complex ring system. The compound hypherone A and the compound hypherone L both have the activity of enhancing the current of a voltage-gated T-type calcium channel, can be used for preparing medicines for treating neurodegenerative diseases, particularly can be used for preparing medicines for relieving and / or treating diseases such as spinal cerebellar ataxia, Alzheimer's disease and intellectual syndrome, and have clinical application value.

A complex for blocking dentinal tubules, characterized in that the complex is formed by means of polymerizing catecholamine and metal ions. The catecholamine comprises one or more of dopamine, norepinephrine, tannic acid, gallic acid, phlorotannins, phloroglucinol monomers and epigallocatechin gallate; and the metal ions comprise one or more of V 2+, Cr 2+, Cr 3+, Mn 2+, Mn 3+, Fe 2+, Fe 3+, Co 2+, Ni 2+, Cu 2+ and Sr 2+. A reagent for treating dentin allergy comprises the complex for blocking dentinal tubules, can block nearly 85% of dentinal tubules within 3 minutes, and can form a crystal structure similar to hydroxyapatite after being mineralized in vitro for 7 days. In addition, in 7-day animal experiments with SD rats, results consistent with in-vitro mineralization experiments are also observed. Moreover, the complex can not only be rapidly prepared, but also has antibacterial ability against pathogenic bacteria of dental caries, and also has good biocompatibility.

The invention discloses a PEI-coated HPAN / COF nanofiber ultrafiltration membrane and a preparation method and application thereof, and belongs to the technical field of ultrafiltration membranes, the preparation method comprises the following steps: preparing a spinning solution from polyacrylonitrile, N, N-dimethylformamide and 1, 4-phenylenediamine; the preparation method comprises the following steps: carrying out needle-free electrostatic spinning, dipping an obtained fiber membrane in an absolute ethyl alcohol solution of trialdehyde phloroglucinol, taking out and cleaning, then completely dipping in an alkaline solution, taking out and washing, drying to obtain an HPAN / COF nanofiber membrane, dipping the HPAN / COF nanofiber membrane in a PE I solution for treatment, taking out, washing and drying to obtain a PE I-coated HPAN / COF nanofiber ultrafiltration membrane, and carrying out electrostatic spinning on the membrane to obtain the HPAN / COF nanofiber ultrafiltration membrane. Functional groups of the ultrafiltration membrane are combined with heavy metal ions through chemical modes such as chelation and electrostatic interaction, various heavy metals can be accurately removed, and the problem that a traditional ultrafiltration membrane is insufficient in heavy metal ion removal depth and breadth is effectively solved.