152 results about "Ditazole" patented technology

β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.

β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.

The present invention is directed to substituted 5-trifluoromethyl oxadiazole compounds of generic formula (I) or a pharmaceutically acceptable salt thereof. In particular, the invention is directed to a class of aryl and heteroaryl substituted 5-trifluoromethyl oxadiazole compounds of formula I which may be useful as HDAC6 inhibitors for treating cellular proliferative diseases, including cancer, neurodegenerative diseases, such as schizophrenia and stroke, as well as other diseases.

Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C₁-C₄ alkyl, or (ii) R₁ and R₂ together with the carbon atom to which they are attached, form a cyclic group; and Q is H, C_1-6alkyl, phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents, and G is defined herein. Also disclosed are method of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. There compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory disease.

The invention discloses a rhodamine derivative and a preparation method and application thereof. The rhodamine derivative is prepared by reacting rhodamine hydrazide and 4-chloro-7-nitro-2,1,3-benzoxaoxadiazole in the presence of an acid binding agent. The Cu<2+> and Fe<3+> can be respectively detected at high selectivity and high sensitivity. The designed and synthesized structure is short in synthetic route and mild in reaction conditions, the obtained derivative can be used for an aqueous phase system, and the ultraviolet-visible absorption spectrum and fluorescence spectrum are insensitive to the acid-base property of the system.

The invention relates to a compound containing 1,3-benzodiazole connected in series with gem-difluoromethylene groups and a synthesis method thereof. The structural formula of this type of compound is: where R is: -COOEt-Ph, -COOCH3-Ph, -NO2-Ph, Ph, -OCH3-Ph, -CH3-Ph, -CH3-Ph, -NO2-Ph, Pyridine, (Z)-CH=CHCOOEt, (E)-CH=CHCOOEt or (E)-CH=CHPh; X is: O, S or NCH2CH2CH2CH3. The compounds containing 1,3-benzodiazoles in tandem with gem-difluoromethylene groups of the present invention exhibit unique properties in novel liquid crystal materials, so efficient synthesis of such compounds becomes very meaningful. The synthesis method has the characteristics of simple operation, short steps and convenient post-processing.

The invention discloses a 5-methyl-1, 3, 4-oxadiazole-2 (3H)-ketone and making method, which is characterized by the following: looping acetydrazide and trichloromethyl chloroformate or di (trichloromethyl) carbonate to obtain the product; adopting pyridine or 4-dimethylamino pyridine as catalyst; using 1, 2-dichloroethane as dielectric solvent.

The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof; and the related products including N- (fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N- (fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azole anion compound, a silylazole, or a combinationthereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azole anion compounds, or silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, a silylazole, or a combination thereof in one pot.

The invention discloses a selenole derivative structure and application thereof. According to the selenole derivative structure and the application thereof, selenadiazole with a tumor activity is modified, so that the utilization rate of an anti-tumor medicine is increased, and the toxic and side effect is reduced. Meanwhile, by use of the fluorescent property of an indole group, tumor cells and tissues are effectively imaged to realize diagnoses and treatment effects. The anti-tumor action of the selenadiazole is researched to find that the targeted selenadiazole is high in anti-tumor activity and can obviously improve the capacity of killing tumors by X-ray radiotherapy and NK immune cells, so that the selenadiazole has a wide application prospect. The raw materials of the selenole derivative structure are low in cost and easy to obtain, and the selenole derivative structure is high in product repetitiveness and stability.

The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to a synthesis method of a 1, 3, 4-oxadiazole heterocyclic compound. The method comprises thefollowing steps: by taking a ketonic acid derivative and a trivalent iodine reagent as raw materials, adding a solvent and a photocatalyst, and reacting at room temperature under an illumination condition, thereby obtaining the 1, 3, 4-oxadiazole heterocyclic compound. By using the method provided by the invention, the 1, 3, 4-oxadiazole heterocyclic derivative can be obtained by a one-step methodthrough reaction for 5-10 hours at room temperature, and the yield is 75-96%. According to the reaction, the 1, 3, 4-oxadiazole heterocyclic derivative is simply, conveniently and rapidly synthesizedby using simple and easily available raw materials in one step under an illumination condition, and a simple, efficient and mild new synthesis method is provided for synthesizing the 1, 3, 4-oxadiazole heterocyclic derivative.