481 results about "Thiadiazoles" patented technology

The invention discloses an indole-benzothiadiazole derivative as well as a preparation method and application thereof. The general structural formula of the indole-benzothiadiazole derivative provided by the invention is shown in the specification, wherein R is selected from one of methyl piperazinyl, diethylamino, azetidinyl and pyrrolidinyl. The derivative can be specifically combined and fluorescently labeled with mitochondrial RNA in cells, and has good selectivity, high fluorescence signal-to-noise ratio and excellent anti-interference capability in a complex biological system. Meanwhile, the indole-benzothiadiazole derivative provided by the invention is simple in synthetic route, easily available in raw materials, good in stability and convenient to store and use, can be specifically combined with RNA and generate strong fluorescence response, is suitable for real-time detection and imaging of in-vitro and in-vivo mitochondrial RNA, and is an efficient mitochondrial RNA micromolecular fluorescent probe.

Disclosed herein are certain thiadiazolyl derivatives Formula (I):that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and / or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

The application discloses a kind of ship super-long anticorrosion special nano powder coating, preparation method and application, belong to ship heavy anticorrosion material technical field.The preparation method of the ship super-long anticorrosion special nano powder coating is as follows: epoxy resin, graphene modified epoxy resin, core-shell structure ZnO@SiO2, modified 2,5-dimercapto-1,3,4-thiadiazole, borosilicate glass powder, flaky boron nitride, silane coupling agent modified silica, phenolic amine curing agent, 2-ethyl-4-methylimidazole, fumed silica, defoaming agent, ultraviolet absorber, high-temperature pigment are put into stirrer and stirred for 20-30min, then melt extrusion is carried out through double screw extruder, the extrusion temperature is 90-110 DEG C, grinds and sieves, and the ship super-long anticorrosion special nano powder coating is obtained.The coating prepared by the application has good anticorrosion performance and can be applied in the field of ship metal surface corrosion protection.

The invention discloses an acid liquid system based on synergistic interaction of a corrosion inhibitor and an iron stabilizer and a preparation method, and relates to the technical field of oilfield chemistry, the acid liquid system comprises the following components by mass: 10%-20% of an acid liquid, 0.5%-3% of a composite corrosion inhibitor, 0.5%-2% of an iron stabilizer, 0.1%-0.5% of a discharge aiding agent, 0.2%-0.8% of an acid thickening agent, and the balance of water; the main component of the composite corrosion inhibitor in the acid liquid system is long-chain alkyl bis-imidazoline-thiadiazole amide hydroxypropyl sulfobetaine, and the composite corrosion inhibitor contains a bis-imidazoline ring and a thiadiazole amide ring, and can form more stable multi-active-site adsorption on the metal surface to form a compact and stable protective film, so that the metal surface corrosion resistance is improved, and the metal surface corrosion resistance is improved. Long carbon chains in molecules can effectively block corrosive media, N, O and S heteroatoms in the molecules are adsorbed on the iron surface through lone pair electrons to inhibit corrosion, the slow-release effect is further enhanced, and therefore the slow-release efficiency is improved by 40% or above.

The invention relates to the technical field of materials and advanced oxidation, and discloses a covalent organic framework catalyst with a benzothiadiazole structure, a preparation method of the covalent organic framework catalyst and application of the covalent organic framework catalyst in peroxymonosulfate (PMS) activation and organic pollutant degradation. The preparation method of the covalent organic framework catalyst comprises the following steps: adding precursors 1, 3, 6, 8-tetra-(p-aminophenyl)-pyrene and 2, 7-dibenzaldehyde-benzothiadiazole into a mixed solvent composed of o-dichlorobenzene and n-butyl alcohol, carrying out a reaction by using acetic acid as a catalyst through a solvothermal method, and after the reaction, carrying out multiple times of centrifugal washing and drying to obtain the covalent organic framework catalyst. The catalyst shows excellent performance in the aspect of activating PMS to degrade organic pollutants, the degradation rate constant of bisphenol A reaches 1.68 min <-1 >, and 100% removal can be achieved within 5 minutes. Meanwhile, the catalyst has the advantages of no secondary pollution, strong anti-interference performance, reusability and the like. Compared with a traditional method, the catalyst has high PMS activation efficiency, the catalysis process is energy-saving and environment-friendly, the operation is simple and convenient, the preparation process is simple and feasible, and a new solution is provided for efficient degradation of organic pollutants in water.

The invention provides a covalent organic framework material as well as a preparation method and application thereof, 1, 3, 6, 8-tetra (4-aminophenyl) pyrene is selected as a central construction unit, and a trap state is realized in a covalent organic framework (COFs) by regulating and controlling the symmetry of active sites (benzothiadiazole, BT). Compared with a centrosymmetric counterpart in the COFs, by breaking the symmetry of the center BT core, the trap state density in the COFs can be remarkably reduced, and the service life of the shallow trap state can be prolonged to 1160.02 picoseconds. Therefore, more photo-induced electrons can participate in the photocatalytic reaction, and the remarkable performance (greater than 99%) of photocatalytic reduction of uranium (VI) is finally realized. According to the invention, the key effect of symmetric breaking in inhibition of excited state decay of COFs is clarified for the first time, and a profound solution is provided for understanding how to improve the photocatalytic performance of COFs in environmental restoration.

There is provided an alkali metal salt of 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide and formulations thereof. This salt finds particular utility in the treatment or prevention of a disorder or condition ameliorated by the activation of AMPK.

The invention relates to the technical field of cables, and provides a crosslinked polyethylene high-voltage cable which comprises a conductor, an insulating layer and a protective sleeve which are arranged from inside to outside. The protective sleeve comprises the following components in parts by weight: 50-80 parts of high-density polyethylene, 0.5-1 part of a cross-linking agent, 10-20 parts of a composite flame retardant, 0.5-1 part of an antioxidant, 0.5-1 part of a lubricant, 2-3 parts of polyethylene grafted maleic anhydride and 1-2 parts of carbon black. The flame-retardant monomer disclosed by the invention has the beneficial effects that the flame-retardant monomer has phosphorus-nitrogen synergistic flame-retardant and interface enhancing functions. The thiadiazole ring acts with the surface of aluminum hydroxide, so that the dispersity is improved, the mechanical property of the material is enhanced, and the flame-retardant efficiency is improved. The aluminum hydroxide is more efficient in thermal decomposition after being uniformly dispersed, and cooperates with the gas-phase flame-retardant and char-forming effects of the flame-retardant monomer to form a compact protective layer, so that the integration of flame retardance and enhancement is realized. And aluminum hydroxide with good dispersion can also be used as a rigid particle reinforced matrix, so that stress concentration is avoided.

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

The invention provides a coumarin derivative containing oxadiazole (thiadiazole) thioether and a preparation method and application thereof, the structural general formula of the coumarin derivative containing oxadiazole (thiadiazole) thioether is shown as I, and the structural general formula of the coumarin derivative containing thiadiazole thioether is shown as II, the synthesis route of the coumarin derivative containing oxadiazole (thiadiazole) thioether is simple and practical, the preparation raw materials are easy to obtain, the cost is low, and the prepared compound has a good control effect on plant viruses including tobacco mosaic virus, cucumber mosaic virus, potato Y virus, southern rice black-streaked dwarf virus or rice stripe virus. According to the invention, a favorable lead compound is provided for the creation of a natural bionic antiviral agent; # imgabs0 #

The invention discloses a natural nitrogenase-like FeMo nano-enzyme and a preparation method and application thereof, and relates to the technical field of nano-enzymes and agriculture, the method comprises the following steps: respectively dissolving 1, 3, 4-thiadiazole-2, 5-diamine, molybdenum pentachloride, ferric chloride and 2, 5-thiophenedicarboxylic acid in absolute ethyl alcohol; the preparation method comprises the following steps: adding a molybdenum pentachloride solution and a ferric chloride solution into a 1, 3, 4-thiadiazole-2, 5-diamine solution, and stirring until the solution is yellowish-brown to obtain a FeMo nano-enzyme mixed solution; and adding a 2, 5-thiophenedicarboxylic acid solution into the FeMo nano-enzyme mixed solution, stirring, and sequentially centrifuging, drying and calcining to obtain the natural nitrogenase-like FeMo nano-enzyme. The FeMo nano-enzyme has nitrogen fixation activity similar to that of natural nitrogenase, nitrogen and water can generate ammonia at normal temperature and normal pressure, and the technical problem that in-situ generation of ammonia in plants at normal temperature and normal pressure is difficult in the prior art is solved.

The invention discloses a gold nanocluster electrogenerated chemiluminescence probe which is a multifunctional gold nanocluster obtained by taking a 2-sulfydryl-1, 3, 4-thiadiazole ligand as a reducing agent or a protective agent. Comprising a solid-phase probe with a gold cluster modified on an electrode; or the gold cluster is independent of the electrode and is a liquid-phase probe dissolved in the electrolyte during use. The obtained electrogenerated chemiluminescence gold nanocluster probe can generate an electrogenerated chemiluminescence signal under the condition of no co-reactant, and is relatively low in luminescence potential, high in quantum yield and good in biocompatibility.

The invention discloses a preparation method and antibacterial application of a naphthothiadiazolyl photosensitizer, and belongs to the technical field of biomedical antibacterial materials. The naphthothiadiazole-based photosensitizer provided by the invention overcomes the problem that the existing commercial photosensitizer gathers and quenches the active oxygen efficiency, and meanwhile, the antibacterial photosensitive polymer prepared based on the novel naphthothiadiazole-based photosensitizer has the unique advantages that the structure is stable, photosensitizer micromolecules are not easy to leak and the antibacterial effect is long-acting; the construction of the antibacterial polymer coating on the surface of the medical instrument in the future has important clinical application potential. The naphthothiadiazolyl photosensitizer provided by the invention has good photodynamic killing performance on drug-resistant bacteria MRSA (Methicillin Resistant Staphylococcus Aureus).

The invention discloses the technical field of photocatalysis, and particularly discloses a preparation method of a visible-light response type covalent organic frame-TiO2 composite material, which comprises the following steps: adding TiO2 into a mixed solvent, carrying out ultrasonic dispersion, dropwise adding an H2PtCl6 aqueous solution while stirring, reacting under the irradiation of a mercury lamp, centrifuging, washing and drying to obtain a Pt-TiO2 material; the preparation method comprises the following steps: dispersing a Pt-TiO2 material in an organic solvent, adding 2-hydroxybenzene-1, 3, 5-tricarboxaldehyde and 4, 4 '-(benzo [c] [1, 2, 5] thiadiazole-4, 7-diyl) diphenylamine, carrying out ultrasonic treatment for 3-8 minutes, and then adding acetic acid; after 2-4 times of liquid nitrogen freezing-degassing, sealing, and reacting for 2-5 days at the temperature of 110-130 DEG C; and centrifuging, washing and drying to obtain the covalent organic frame-TiO2 composite material. The novel covalent organic frame-TiO2 composite material prepared by the invention effectively expands the visible light absorption range of TiO2, has strong visible light absorption and strong photocatalytic performance, can efficiently catalyze hydrogen evolution, and has excellent light stability and repeatability in photocatalytic hydrogen evolution reaction.

The invention discloses a degradable packaging material and a preparation method thereof, and relates to the field of packaging materials. When the degradable packaging material is prepared, after vermiculite powder is grafted with chloromethyltrimethoxysilane, the vermiculite powder reacts with piperazine, bis (2-chloroethyl) methylphosphonate and ethylenediamine, and modified vermiculite powder is obtained; oxidizing corn starch with sodium periodate to obtain modified corn starch; the preparation method comprises the following steps: reacting polyvinyl alcohol, allyl trimethyl ammonium chloride and 5-allyl mercapto-[1, 3, 4] thiadiazole-2-amine to obtain modified polyvinyl alcohol; and uniformly mixing the modified corn starch, glycerol, modified polyvinyl alcohol, modified vermiculite powder and zinc chloride to obtain the degradable packaging material. The degradable packaging material prepared by the invention has excellent flame retardance, antibacterial property, mechanical property and rapid degradability.

The invention provides a long-acting anticorrosive epoxy powder coating and a preparation method thereof. The coating comprises epoxy resin, polyester resin, thiadiazole corrosion inhibitor loaded cerium-doped hydrotalcite composite particles, silane modified mica iron oxide, zinc phosphate, barium sulfate and the like. The core innovation lies in that 2-amino-5-(4-hydroxyphenyl)-1, 3, 4-thiadiazole corrosion inhibitor molecules are designed and synthesized, the molecules are loaded between cerium-doped magnesium-aluminum hydrotalcite nano container layers through an anion exchange method, corrosion environment pH responsive gradient release is achieved, a coating constructs a passive shielding, active corrosion inhibition and interface anchoring triple protection mechanism in the coating, and the corrosion resistance of the coating is improved. The neutral salt spray test resistance exceeds 2000h, and the coating is suitable for long-acting corrosion protection of iron accessories and cable bridges.

There has been a need for a novel lubricating oil composition which has characteristics (for example, scuffing resistance and copper corrosion resistance) that are suitable for lubrication of various mechanisms that are incorporated in a device. The present invention provides a lubricating oil composition which contains (A) a base oil and (B) a phosphite ester that has at least one sulfur atom-containing group having 2 to 20 carbon atoms, the group having at least one —(S) x- group (wherein x is an integer of 1 or more) between two adjacent carbon atoms in the structure of an alkyl group, wherein: the content of a thiadiazole compound is less than 0.05% by mass based on the total amount of the lubricating oil composition; and the kinematic viscosity of the lubricating oil composition at 100° C. is 4.2 mm2 / s or more.

Provided is a rubber composition with which it is possible to obtain a vulcanized product and a vulcanized molded product having excellent wear resistance. According to the present invention, there is provided a rubber composition containing a chloroprene rubber, silica, a silane coupling agent, and a hydrate, the rubber composition containing 5-80 parts by mass of silica and 0.5-20 parts by mass or more of hydrate per 100 parts by mass of the chloroprene rubber, and the rubber composition containing 5-80 parts by mass of silica and 0.5-20 parts by mass of hydrate per 100 parts by mass of the chloroprene rubber. The content of a silane coupling agent is 0.5-15 parts by mass per 100 parts by mass of the silica, and the rubber composition satisfies at least one of the following conditions i) and ii): condition i) the rubber composition contains 3-methyl-thiazolidine-2-thione, and in the rubber composition, the content of 3-methyl-thiazolidine-2-thione is 0.5-15 parts by mass per 100 parts by mass of the chloroprene-based rubber, and the content of 3-methyl-thiazolidine-2-thione is 0.5-15 parts by mass per 100 parts by mass of the chloroprene-based rubber. The composition contains 0.1 to 3.0 parts by mass of 3-methyl-thiazolidine-2-thioketone; condition ii) the rubber composition contains a compound A and a compound B. The compound A is at least one compound selected from the group consisting of thiourea compounds, 3-methyl-thiazolidine-2-thione, and bis (5-mercapto-1, 3, 4-thiadiazol-2-yl) disulfides, and the compound B is at least one compound selected from the group consisting of thiourea compounds, 3-methyl-thiazolidine-2-thione, and bis (5-mercapto-1, 3, 4-thiadiazol-2-yl) disulfides. The compound B is at least one compound selected from the group consisting of thiuram-based compounds, sulfinamide-based compounds, thiazole-based compounds, guanidine-based compounds, benzimidazole-based compounds, N-phenyl-N-(trichloromethylthio) benzsulfonamide, and diazabicyclo-undecene-based compounds, and the content of the compound B is 100 parts by mass per 100 parts by mass of the chloroprene rubber. The rubber composition contains 0.1 to 3.0 parts by mass of a compound A and 0.01 to 3.0 parts by mass of a compound B.

The invention provides sulfonated ionic liquid as well as a preparation method and application thereof, the preparation method of the sulfonated ionic liquid comprises the following steps: dropwise adding sultone into an organic solution of 2-amino-5-sulfydryl-1, 3, 4-thiadiazole, and carrying out condensation reflux reaction at 90 DEG C for 24 hours; carrying out reduced pressure suction filtration to remove the solvent, washing the solid, and drying to obtain an ionic liquid onium salt precursor; dissolving the ionic liquid onium salt precursor in water, slowly dropwise adding inorganic acid, and reacting at 90 DEG C for 10 hours; and after the reaction is finished, performing reduced pressure distillation to remove water, washing the solid to remove the inorganic acid, the residual raw materials and byproducts, performing reduced pressure distillation to obtain a solid, and drying to obtain the sulfonated ionic liquid. The sulfonated ionic liquid does not corrode equipment, can efficiently catalyze oleic acid esterification reaction to prepare biodiesel, and can be recycled. The sulfonated ionic liquid disclosed by the invention has good application prospects and large-scale popularization potential in the field of catalyzing oleic acid to prepare biodiesel.

The invention discloses a benzothiadiazole metal covalent organic framework material as well as a preparation method and application thereof, and belongs to the technical field of MCOF photocatalytic materials. The metal covalent organic framework BTD-MCOF shown in the structural formula (I) is synthesized through the dehydration condensation reaction of aldehyde groups and amino groups, the prepared BTD-MCOF photocatalytic material is large in specific surface area and high in porosity, and due to the advantages of large specific surface area, high porosity and the like, the BTD-MCOF has huge application potential in the aspects of gas storage, sensing and the like, and the application prospect is broad. Meanwhile, the hydrogen evolution performance of the prepared sample in the absence of a promoter is 1012 [mu] mol.g <-1 >. H <-1 >, which exceeds the hydrogen evolution performance of most pure COF and MOF.

The invention discloses a water-soluble near-infrared two-region aggregation-induced emission material and a preparation method and application thereof, and belongs to the technical field of aggregation-induced emission materials.Benzobithiadiazole is used as an electron acceptor group, dithieno-cyclopentadiene and derivatives thereof are used as electron donor units, and benzobithiadiazole and dithieno-cyclopentadiene and derivatives thereof are coupled to form the water-soluble near-infrared two-region aggregation-induced emission material. The organic near-infrared second-region molecule with the intramolecular charge transfer characteristic is constructed. According to the invention, the positively charged quaternary ammonium salt group is introduced into the electron donor group, and the positively charged quaternary ammonium salt group has good hydrophilicity, so that the water solubility of molecules can be effectively improved. Moreover, the water-soluble near-infrared two-region aggregation-induced emission material has excellent photodynamic and photothermal activity, and realizes efficient killing of bacteria (especially propionibacterium acnes) through the synergistic effect of photodynamic and photothermal effects.

The invention provides a vanillin compound spliced by polyheterocycles. The polyheterocycles are one of a benzimidazole ring, a thiadiazole ring, an oxadiazole ring and a thiazole ring; the vanillin compound spliced by polyheterocycles is one of vanillin derivatives containing a benzimidazole ring, a thiadiazole ring, an oxadiazole ring and a thiazole ring, and the chemical general formula is shown in the specification. The polyheterocycle spliced vanillin compound is prepared through a condensation reaction and a condensation-cyclization reaction, and the compound has good antibacterial activity on valsa mali, red kidney bean root rot, fusarium graminearum, millet pyricularia grisea, botrytis cinerea, alternaria solani and watermelon fusarium oxysporum. The compound can be used for preparing a novel efficient antibacterial agent and is applied to prevention and treatment of the pathogenic bacteria.

The invention belongs to the technical field of biosensing of organic electrochemical transistors, and particularly relates to an organic electrochemical transistor based on a spirobifluorene polymer as well as a preparation method and application of the organic electrochemical transistor. An active layer of the organic electrochemical transistor is composed of poly [benzo [2, 1, 3] thiadiazole-4, 7-diyl-[5-[3, 6-bis (octyloxy)-9, 9 '-spirobis [9H-fluorene]-2-yl]-1, 3-phenylene]], an ionic gel layer is prepared by mixing PVDF-HFP, EMIM TFSI and Li TFSI, and a gate electrode is modified with MnO2 nanoparticles and poly [benzo [2, 1, 3] thiadiazole-4, 7-diyl-[5-[3, 6-bis (octyloxy)-9, 9'-spirobis [9H-fluorene]-2-yl]-1, 3-phenylene]-1, 3] thiadiazole-4, 7-diyl-[5 and 2, 3-phenylene]]. The organic electrochemical transistor can be used for detection of hydrogen peroxide, is high in detection sensitivity, good in selectivity and wide in application range, and provides a new solution for detection of hydrogen peroxide.

This invention relates to an integrated electrocapture and conversion catalyst, its preparation method, and its application in the electroreduction of flue gas to produce carbon monoxide. The catalyst consists of gold nanoparticles modified with thiadiazole-based organic ligands, including 2-amino-5-mercapto-1,3,4-thiadiazole, 2-mercapto-5-methyl-1,3,4-thiadiazole, or 2,5-mercapto-1,3,4-thiadiazole. This invention provides a method for preparing the aforementioned integrated electrocapture and conversion catalyst. This method features mild preparation conditions, a simple and clear process, and good reproducibility. The thiadiazole-based organic molecular layer captures carbon dioxide in a reduced state, achieving local enrichment of carbon dioxide. The enriched carbon dioxide is further reduced to carbon monoxide by the gold nanoparticles. In flue gas with a 15% carbon dioxide concentration, a carbon monoxide Faraday efficiency of up to 80.4% can be obtained.

This invention relates to a 1,3,4-thiadiazole peptide deformylase inhibitor and its preparation and application. The structural formula is shown in formula (1): wherein, R 1 It is n-butyl or cyclopentylmethyl; R 2 The compounds are hydrogen-containing, straight-chain alkanes, cyclic alkanes, aromatic rings, substituted biphenyls, or heterocyclic rings. The 1,3,4-thiadiazole peptide deformylase inhibitors provided by this invention can effectively inhibit bacterial protein synthesis, thereby achieving sterilization. These compounds exhibit excellent inhibitory activity against Gram-positive drug-resistant bacteria, especially the clinically challenging methicillin-resistant Staphylococcus aureus (MRSA). In particular, some preferred compounds show inhibitory activity 4-8 times that of the control standards vancomycin and linezolid. The 1,3,4-thiadiazole peptide deformylase inhibitors provided by this invention also exhibit inhibitory activity against Gram-negative drug-resistant bacteria, especially against drug-resistant Acinetobacter baumannii, known as "superbugs," with an inhibitory activity reaching 0.5 μg / mL, far superior to vancomycin and linezolid.

The application discloses a fused benzothiadiazole derivative, a preparation method thereof, a hole transport material, a hole transport layer and a perovskite battery, and belongs to the technical field of battery materials.The fused benzothiadiazole derivative can be applied as a hole transport material, contains a fused benzothiadiazole unit in a mother nucleus, has a large conjugate core, and has a D-A-D type molecular structure, so that the intermolecular interaction can be strengthened, and the extraction of holes can be promoted.In addition, the fused benzothiadiazole derivative also contains a phosphate group, so that a self-assembled monolayer can be formed in the form of a bidentate bond or a tridentate bond on a transparent conductive glass to improve the contact between the hole transport layer and an ITO interface.Further, the fused benzothiadiazole derivative also contains rich heteroatoms such as sulfur, nitrogen and oxygen, can be used as a Lewis base to passivate free lead iodine ions at the interface, so that the loss caused by charge recombination can be reduced, and the performance of an inverted perovskite solar cell can be improved.

This invention discloses a class of thiadiazole-benzohexacyclic compounds, their preparation methods, and applications. The structural formula is shown in Formula I. This invention introduces disulfide bond fragments into the thiadiazole-benzohexacyclic skeleton to obtain a novel class of thiadiazole-benzohexacyclic compounds. These compounds have a novel structure, a simple preparation method, readily available raw materials, and are unlikely to produce harmful byproducts. The compounds exhibit inhibitory effects against various plant pathogenic bacteria, particularly against *Citrus canker*, *Ralstonia solanacearum*, and *Bacterial angular leaf spot* of cucumber, demonstrating significant inhibitory effects. They can be used as agricultural bactericides and have great application value.

The invention relates to the technical field of anti-cancer chemical drugs, in particular to a thiadiazole tetranuclear copper complex with anti-tumor and antibacterial activity and a preparation method and application of the thiadiazole tetranuclear copper complex. The chemical formula of the complex is [Cu4 (C3H3S2N2) 2 (C3H4S2N2) 4], the complex is synthesized from ligand thiadiazole and CuX, X is I or Br, and copper in the obtained complex is + 1 valence. The complex shows a good cytotoxic effect on breast cancer cells MCF-7, is likely to play a toxic effect by inducing apoptosis, ferroptosis, copper death and other ways, has a good antibacterial effect, has potential medicinal value, and is expected to be developed into a new generation of anti-tumor drugs with antibacterial properties.

The invention relates to the technical field of lubricating oil, in particular to pitting-corrosion-resistant automobile transmission lubricating oil and a preparation method thereof. The method comprises the following steps: (1) mixing and filtering spiral carbon nanotubes, 2, 5-bis (octyl dithio) thiadiazole and pentaerythritol tetraborate triethanolamine ester, and mixing a filtered substance, an antioxidant and phosphorus-doped NiMn-coated CuO / CF treated by a first coupling agent to obtain a composite extreme pressure agent; (2) mixing a composite extreme pressure agent, a purification dispersant, a defoaming agent, a viscosity index improver and the nano-copper treated by the second coupling agent to obtain a composite additive; and (3) uniformly mixing the composite additive, the hydroxylated poly-alpha-olefin and methylcyclopentane according to the mass ratio of (0.1-0.3): 1: (2-3) to obtain the pitting-corrosion-resistant automobile transmission lubricating oil. The composite extreme pressure agent can sequentially form a plurality of extreme pressure agents to form a multi-layer film, so that the wear resistance of the lubricating oil is improved. The lubricating oil provided by the invention has excellent wear resistance.

To provide a lubricating composition for a transmission, an axle, a tractor, or an industrial gear, which achieves desired load-bearing capacity while achieving improved copper corrosion performance, and a method for lubricating a transmission.SOLUTION: A lubricating composition suitable for use in a transmission of a vehicle, the lubricating composition comprising one or more base oils of lubricating viscosity, at least about 0.35 weight percent of a thiadiazole additive, and one or more substituted trisaryl phosphites having an overall ratio of para-substituted to ortho-substituted between about 0.5 and about 2.0.SELECTED DRAWING: None