48 results about "Thiadiazoles" patented technology

This invention relates to a 1,3,4-thiadiazole peptide deformylase inhibitor and its preparation and application. The structural formula is shown in formula (1): wherein, R 1 It is n-butyl or cyclopentylmethyl; R 2 The compounds are hydrogen-containing, straight-chain alkanes, cyclic alkanes, aromatic rings, substituted biphenyls, or heterocyclic rings. The 1,3,4-thiadiazole peptide deformylase inhibitors provided by this invention can effectively inhibit bacterial protein synthesis, thereby achieving sterilization. These compounds exhibit excellent inhibitory activity against Gram-positive drug-resistant bacteria, especially the clinically challenging methicillin-resistant Staphylococcus aureus (MRSA). In particular, some preferred compounds show inhibitory activity 4-8 times that of the control standards vancomycin and linezolid. The 1,3,4-thiadiazole peptide deformylase inhibitors provided by this invention also exhibit inhibitory activity against Gram-negative drug-resistant bacteria, especially against drug-resistant Acinetobacter baumannii, known as "superbugs," with an inhibitory activity reaching 0.5 μg / mL, far superior to vancomycin and linezolid.

This invention discloses a class of thiadiazole-benzohexacyclic compounds, their preparation methods, and applications. The structural formula is shown in Formula I. This invention introduces disulfide bond fragments into the thiadiazole-benzohexacyclic skeleton to obtain a novel class of thiadiazole-benzohexacyclic compounds. These compounds have a novel structure, a simple preparation method, readily available raw materials, and are unlikely to produce harmful byproducts. The compounds exhibit inhibitory effects against various plant pathogenic bacteria, particularly against *Citrus canker*, *Ralstonia solanacearum*, and *Bacterial angular leaf spot* of cucumber, demonstrating significant inhibitory effects. They can be used as agricultural bactericides and have great application value.

This invention discloses a method for improving the resistance to postharvest black spot disease in sweet potato tubers and maintaining their quality, belonging to the field of postharvest preservation technology for agricultural products. The method includes: selecting undamaged sweet potato tubers for callus treatment at room temperature for 48 hours, disinfecting with 1% sodium hypochlorite, rinsing with sterile water and air-drying, then soaking them in a 9.0 mmol / L benzothiadiazole (BTH) solution (containing 0.05% Tween 80) at room temperature for 60 minutes, removing them and air-drying them to complete the treatment. This invention induces the activation of the sweet potato tuber's own defense system through BTH, increasing the activity of key enzymes in phenylpropane metabolism, chitinase and other disease-resistant enzymes, promoting the accumulation of total phenols and lignin, maintaining cell membrane integrity, inhibiting starch degradation and abnormal increase in soluble sugars. Under storage conditions of 28±1℃ and 80-85%RH, it can significantly inhibit the expansion of black spot disease lesions and extend the storage period to more than 25 days. This method has no pesticide residues, is unlikely to cause pathogen resistance, is environmentally friendly, simple to operate, and cost-controllable, and is suitable for large-scale postharvest preservation of sweet potato tubers.

The application discloses a kind of near-infrared benzothiadiazole dye sensitized rare earth upconversion luminescence nano-probes and preparation method thereof;Probe is composed of near-infrared benzothiadiazole dye and upconversion nanoparticle, benzothiadiazole dye is compounded with ligand-free lanthanide ion doped upconversion nanoparticle, and upconversion luminescence is enhanced.This application preparation method is simple, and it does not involve complex core-shell structure and energy migration process, benzothiadiazole dye is directly compounded with ligand-free rare earth nanoparticle, and upconversion luminescence nano-probe is formed, under the irradiation of 808nm laser, the emission spectrum of benzothiadiazole dye and the absorption spectrum of sensitizer ion in upconversion nanoparticle overlap, which can effectively enhance the upconversion luminescence intensity of nano-probe, and keep good light stability, keep more than 90% of initial luminescence intensity under the irradiation of 120 minutes excitation light.

This application relates to a perovskite solar cell, its fabrication method, a tandem solar cell, and a photovoltaic module. The perovskite solar cell includes a first electrode, a hole transport layer, a perovskite light-absorbing layer, and a second electrode. The hole transport layer is located between the first electrode and the perovskite light-absorbing layer, and between the hole transport layer and the second electrode. The hole transport layer comprises a compound shown in formula (I). This perovskite solar cell uses the compound shown in formula (I) as the hole transport layer material. The compound shown in formula (I) is a polymer, and its monomers are based on indolo[3,2-b]carbazole, with fluorine-substituted benzothiadiazole groups and phosphonic acid groups introduced. This can passivate defects in the perovskite light-absorbing layer, suppress interfacial electron recombination, and enable the perovskite solar cell to achieve better photoelectric conversion efficiency.

This invention provides a cyan-transparent electrochromic polymer, its preparation method, and its applications, belonging to the field of electrochromic polymer technology. The invention uses 6,6'-(2,6-dibromo-4H-cyclopentano[2,1-b:3,4-b']dithiophene-4,4-diyl)bis(hexyl-1-ol), 2,6-di(trimethyltin)-4,4-di(2-ethylhexyl)-dithiophenecyclopentadiene, and 4,7-dibromobenzo[c][1,2,5]thiadiazole as main raw materials, reacting them under the action of a catalyst to obtain a cyan-transparent electrochromic polymer. The film made from the cyan-transparent electrochromic polymer of this invention has an optical contrast ratio of 47.01% in the 719 nm wavelength range, a coloring time of 0.81 s, and a fading time of 0.32 s.

This application provides a method for preparing and applying a red reactive dye. The method includes the following steps: S1: providing 2-amino-5-(β-hydroxyethyl sulfone sulfate)-1,3,4-thiadiazole; S2: reacting the amino-containing red azo compound with cyanuric chloride, causing the amino group on the amino-containing red azo compound to undergo a substitution reaction with one chlorine atom in the cyanuric chloride, to obtain a red azo compound containing a dichlorotriazine group; S3: reacting the 2-amino-5-(β-hydroxyethyl sulfone sulfate)-1,3,4-thiadiazole with the red azo compound containing a dichlorotriazine group, causing the amino group on the 2-amino-5-(β-hydroxyethyl sulfone sulfate)-1,3,4-thiadiazole to undergo a substitution reaction with one chlorine atom in the red azo compound containing a dichlorotriazine group, to obtain a red reactive dye. The red reactive dye prepared by this application exhibits high fixation rate and excellent alkali fastness in fiber dyeing.

The application discloses a preparation method and application of a hollow conjugated microporous polymer. It belongs to the field of photocatalytic organic synthesis and comprises the following steps: step S1, dispersing SiO2 nanosphere templates in a triethylamine solvent; step S2, adding 4,7-dibromo-2,1,3-benzothiadiazole, dichlorobistriphenylphosphine palladium and cuprous iodide; step S3, slowly adding a toluene solution of 1,3,5-triethynylbenzene; step S4, heating, stirring, washing, etching with a hydrofluoric acid solution, washing and drying to obtain the hollow conjugated microporous polymer. The hollow spherical structure of the hollow conjugated microporous polymer enhances light capture; high specific surface area and hierarchical pores promote mass transfer and active site exposure; the D-A type conjugated system constructed by BT units effectively narrows the band gap, expands the visible light response range and greatly improves the charge separation efficiency; and the all-organic composition makes the hollow conjugated microporous polymer environmentally friendly and relatively low in cost.

The application belongs to the field of organic photoelectric functional materials, and discloses an organic up-conversion red light photosensitizer material, a preparation method and application. The material has the structure shown in the following formula (I). The molecule has a D-pi-A-pi-D structure, wherein 4,7-dibromo benzo[1,2-c:4,5-c'] bis([1,2,5]thiadiazole), 4,7-dibromo benzo[c]-1,2,5-thiadiazole, 4,7-dibromo benzo[d]thiazole and 4,7-dibromo-2,1,3-benzoselenadiazole are used as strong electron acceptors, can reduce the energy gap of the molecule, and make the absorption peak / emission peak red shift; triphenylamine is used as a strong electron donor and a pi-bridge, a spiral structure is formed, steric hindrance is increased, and the aggregation-induced emission characteristics are ensured; the carboxyl group on the triphenylamine provides good amphiphilicity for the overall structure. The synthetic route of the application is simple, is a potential red light TADF material, and has good fluorescence quantum yield and up-conversion efficiency.

The present application relates to etching liquid technical field, specifically to a kind of small key size deviation copper etching liquid composition, by mass percentage, including the following components: hydrogen peroxide, ammonium hydrogen fluoride, 2-mercapto-1,3,4-thiadiazole, imidazole, citric acid, malic acid, ammonium sulfate, triethylene glycol, the rest is deionized water.The mass ratio of 2-mercapto-1,3,4-thiadiazole and imidazole is controlled between 1-2 in the present application, and a complementary adsorption layer is formed, wherein imidazole provides basic corrosion inhibition by covering quickly, 2-mercapto-1,3,4-thiadiazole enhances inhibition by strong bonding, and dynamic protection is achieved by the synergistic effect of the two, which can control the rate, improve uniformity and obtain a bright surface;At the same time, strong inhibition side etching, accurate control of etching morphology, especially anisotropy, to obtain steep sidewall and smooth surface;It can meet the etching demand of small CD bias.

The application provides a perovskite solar cell, a preparation method thereof and an electric device. The perovskite solar cell comprises an interface passivation layer, the interface passivation layer comprises inorganic sulfide and organic passivation, cation elements in the inorganic sulfide comprise at least one of Pb, Bi, Mn, Cd, Hg, Ag, Zn, Na or Fe; the organic passivation comprises organic halide and heteroaryl compound, the organic halide comprises at least one of H2N-R 1 ·(HX)2, R 2 ·(HX) n , Ar-R 3 NH3·X, Ar-N(CH3)3·X, R 1 is selected from C1-C6 alkylene; R 2 is selected from substituted or unsubstituted 5-20 membered aliphatic heterocyclyl, 5-20 membered aromatic heterocyclyl; n is 1 or 2; each Ar is selected from substituted or unsubstituted C6-C10 aryl; R 3 is selected from C1-C6 alkylene; the heteroaryl compound comprises a substituted thiadiazole compound.

This invention relates to a photosensitizer with a D1-π-A-π-D2 type structure based on asymmetric end-capped donor units. This material is characterized by using 4-(5-(4-(9H-carbazole-9-yl)phenyl)) as donor units (D1) and 5-(4-(diphenylamino)phenyl) as donor units (D2), with isooctylthiophene as the connecting π-bridge, and phenazine as the central acceptor unit (A), specifically naphthiazo[1,2-b][1,2,5]thiadiazo[3,4-g]quinoxaline and [1,2,5]thiadiazo[3,4-i]dithienozo[2,3-a:3',2'-c]phenazine. The photophysical properties of this D1-π-A-π-D2 type photosensitizer were tested, and a novel photosensitizer with high photothermal conversion efficiency and high reactive oxygen species (ROS) yield was developed. The material involved in this invention has near-infrared II region imaging and photothermal in-situ imaging diagnostic functions, and is expected to be used as an organic photosensitizer material for integrated photothermal and photodynamic diagnosis and treatment.

This invention discloses a nanosheet Tb-MOF fluorescence sensor for detecting Al in phosphogypsum and red mud. 3+ The detection application utilizes Tb(NO3)3·5H2O and H4BTTC as raw materials, with benzoic acid as a modifier, to prepare a Tb-BTTC MOF fluorescent sensor with a nanosheet structure and benzothiadiazole functionalization using a microwave-assisted synthesis method. This material can be used as a fluorescent sensor to detect Al in phosphogypsum and red mud. 3+ This invention utilizes highly selective, "on"-type fluorescence enhancement detection, accompanied by a significant blue shift (approximately 10 nm), with a fluorescence spectroscopy detection limit of 0.065 μM. It constructs an intelligent sensing platform integrating a smartphone and a portable UV lamp, achieving Al2O3 detection through fluorescence color and RGB analysis. 3+ The rapid on-site quantitative detection method can be applied to the rapid and visual detection of aluminum ions in solid wastes such as red mud and phosphogypsum, providing new materials and methods for the real-time and portable detection of aluminum ions in red mud and phosphogypsum.

This disclosure provides, for example, benzo[c][1,2,5]thiadiazolyl compounds and methods using these compounds for treating neurodegenerative disorders such as Parkinson's disease (PD), multiple system atrophy (MSA), and Lewy body dementia. This disclosure provides, 11 C, 18 F, or 123 / 125 The invention also provides methods using benzo[c][1,2,5]thiadiazolyl compounds radiolabeled with radioisotopes such as I, as well as radiolabeled compounds for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) brain imaging agents for diagnosing and / or monitoring the treatment of neurodegenerative disorders.

This invention relates to the field of mineral processing technology, specifically to an inhibitor and method for deactivating and inhibiting the flotation recovery of copper sulfide ore in copper-lead mixed flotation concentrate. The inhibitor for deactivating and inhibiting the flotation recovery of copper sulfide ore in copper-lead mixed flotation concentrate of this invention is composed of 2,5-dimercapto-1,3,4-thiadiazole and sodium mercaptoacetate. This invention utilizes the competitive desorption of residual xanthate on the surface of copper sulfide minerals and the precipitation removal of unavoidable ions in the pulp by 2,5-dimercapto-1,3,4-thiadiazole, synergistically with the selective hydrophilic inhibition of the copper sulfide ore surface by sodium mercaptoacetate. By sequentially adding the combined inhibitor, collector, and frother during the roughing and scavenging stages, a synergistic separation mechanism of "deactivation first, inhibition later" is constructed. This not only solves the problem of difficult removal of residual xanthate and collector adsorption on the surface of copper sulfide minerals after mixed flotation and the difficulty in effective action of subsequent inhibitors, but also overcomes the defects of insufficient selectivity and limited separation efficiency of single inhibitors.

This application relates to the technical field of insulating media, specifically disclosing a low-temperature environmentally friendly insulating media based on plant-based fatty acids, its preparation method, and its application. The low-temperature environmentally friendly insulating media disclosed in this application comprises the following components by weight percentage: 0.3%~0.5% antioxidant, 0.005%~0.02% metal deactivator, and the balance being synthetic ester base oil; the synthetic ester base oil is prepared by esterification reaction of polyols, plant-based fatty acids, catalysts, and water-carrying agents; the metal deactivator is selected from benzotriazole, methylbenztriazole, and thiadiazole. This invention uses plant-based fatty acids, which are recyclable and environmentally friendly raw materials; the prepared insulating media has advantages such as high biodegradability, excellent low-temperature performance, excellent lubrication performance, and high flash point and ignition point.

The present application provides a kind of for improving the luminous efficiency of organic light emitting element and color purity compound, the organic light emitting element material containing the compound, organic light emitting element cover layer material and organic light emitting element.The compound provided by the present application has thiofuran structure, thiazole structure, thiadiazole structure, furan structure, oxazole structure, oxadiazole structure or pyrrole structure on the one hand, and contains a series of aryl, heteroaryl, fused ring aryl, fused ring heteroaryl structure.The organic light emitting element provided by the present application can realize high luminous efficiency and color reproducibility, and the organic light emitting element of the present application can be used for organic EL display, backlight of liquid crystal display, light source of illumination, meter, signboard, identification lamp and the like.The present application provides organic light emitting element with greatly improved luminous efficiency and superior color purity.

This invention discloses a thiadiazolidinone compound with PTPN2 / PTPN1 inhibitory activity, its preparation method, and its applications, belonging to the field of medicinal chemistry. The thiadiazolidinone derivative described in this invention is a compound with the structure shown in general formula (I) or a pharmaceutically acceptable salt thereof. This invention also discloses the application of the above-mentioned thiadiazolidinone derivative in drugs for treating PTPN2 / PTPN1-mediated diseases. The compound disclosed in this invention has significant inhibitory activity against PTPN2 / PTPN1 phosphatases, and has an important influence on tumor development and immune response. It can also be used in combination with immunosuppressants to treat related immune diseases. It can be developed into an antitumor drug with high activity, good selectivity, and low toxicity, and has the characteristics of high plasticity and great potential for future modification.

The present disclosure provides a compound of formula (I): JPEG2026501225000412.jpg44166 [Rings A and R in the formula 1 , R 2 , R 3 , R 4 and m are described herein] or pharmaceutically acceptable salts thereof, methods of preparation, methods of treatment, and pharmaceutical compositions containing same. The present disclosure further relates to the use of compounds of formula (I) and pharmaceutically acceptable salts thereof in the treatment of cGAS-related diseases and disorders.

This invention discloses a quinolinonylpropane sulfonate, its preparation method, and its application. The structural formula of the quinolinonylpropane sulfonate is shown in formula (III). The preparation method is as follows: using 4-methylquinoline and 1,3-propanesulfonic acid lactone as raw materials, a reaction is carried out to obtain product (I); using (4-(diphenylamino)phenyl)boronic acid and 7-bromobenzo[c][1,2,5]thiadiazole-4-carboxaldehyde as raw materials, a coupling reaction is carried out under potassium carbonate and nitrogen atmosphere catalyzed by tetrakis(triphenylphosphine)palladium to obtain product (II); using products (I) and (II) as raw materials, quinolinonylpropane sulfonate (III) is prepared. The quinolinonylpropane sulfonate of this invention exhibits antibacterial activity, especially against Streptococcus pneumoniae, and can be used as an antibacterial agent.

This invention discloses a method for preparing and applying a highly selective photoelectrocatalytic oxidation electrode for furfural compounds. Using TEMPO radical-functionalized organic ligands (H2TPDC-TEMPO), benzothiadiazole-functionalized organic ligands (H2BTDB), and nickel salts as raw materials, a Ni-MOF photoanode material is prepared through a one-step solvothermal in-situ growth process. A highly efficient photoelectrocatalytic synergistic catalytic system is constructed. This material can efficiently catalyze the oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid under low potential conditions, with a product yield exceeding 90.4% and a Faradaic efficiency of 98.2%. Furthermore, the material exhibits excellent structural stability, maintaining stable catalytic activity even after 10 cycles. This invention provides a simple, environmentally friendly, and efficient new solution for the high-value photoelectrocatalytic conversion of furfural compounds, possessing significant practical application value in the fields of green organic synthesis and biomass resource utilization.

The application relates to the technical field of primer materials, in particular to a high-zinc-powder-content epoxy zinc-rich primer and a preparation method thereof, which comprises the following steps: mixing 2,5-dimercapto-1,3,4-thiadiazole with water to adjust the pH to 2.0-3.0, carrying out condensation treatment after adding formaldehyde to obtain PDTDF; under an inert atmosphere, the PDTDF is heated and sheared to coat zinc powder to obtain a composite powder, then the composite powder is mixed with a solvent, an additive and an epoxy resin to obtain a component A after filtration, a polyamide curing agent is mixed with a solvent to obtain a component B, and the component A and the component B are mixed to obtain the high-zinc-powder-content epoxy zinc-rich primer. Through the coating of the PDTDF and the synergistic effect, the system performance is optimized, the adhesion is enhanced, the corrosion resistance is improved, the zinc powder settlement is inhibited, and the comprehensive performance is excellent.

The application provides an N,N'-disubstituted dihydrophenazine heterocyclic compound and a preparation method and application, the heterocyclic compound has a structure shown in formula I; wherein A is a substituted heterocycle selected from pyridine, pyrazine, pyridazine, quinoline, quinoxaline, phthalazine, benzoxadiazole, benzothiadiazole or benzoselenadiazole; the preparation method is to use N,N'-diaryl diamine and corresponding difluoro heterocyclic derivative as raw materials, to synthesize by nucleophilic aromatic substitution reaction, the method has the advantages of mild reaction condition, simple operation, no metal catalyst is used, overcomes the problems of many isomers, low yield and metal residue in the existing metal catalytic coupling method, provides a general strategy for efficient and green synthesis of target compounds, and the structure of the heterocycle A can be changed to accurately control the photophysical properties of the compound. The compound can be used as a fluorescent probe and can be used for preparing an organic electroluminescent device, and has a wide application prospect in the field of photoelectric functional materials.

This invention discloses a dichroic dye with a benzothiadiazole structure, its preparation method, and its application. The dichroic dye with the benzothiadiazole structure is a compound with general formula I. General formula I is the dichroic dye disclosed in this invention, which has good dichroism and photothermal stability. The disclosed preparation method has the characteristics of simple operation, low pollution, and high yield, and is particularly suitable for industrial production.

The present application relates to the technical field of anticancer chemicals, in particular to a thiazole four-core copper complex with antitumor and antibacterial activity, and a preparation method and application thereof.The chemical formula of the complex is [Cu4(C3H3S2N2)2(C3H4S2N2)4], which is synthesized from a ligand thiazole and CuX, wherein X is I or Br, and the copper in the obtained complex is +1 valence.The complex shows good cytotoxicity on breast cancer cells MCF-7, and is likely to exert toxic effects through multiple pathways such as induction of cell apoptosis, ferroptosis and cupric death, and has good antibacterial effect, has potential medicinal value, and is expected to be developed into a new generation of antitumor drugs with antibacterial performance.

The application belongs to the technical field of anti-inflammatory drug development, and discloses an indometacin derivative containing 2-amino-1,3,4-thiadiazole and preparation and application thereof. The derivative is a compound with the structure shown in formula 2 or a pharmaceutically acceptable salt thereof. The application first designs and successfully synthesizes a novel indometacin derivative containing 2-amino-1,3,4-thiadiazole, and the structure is characterized. The preparation method of the indometacin derivative containing 2-amino-1,3,4-thiadiazole is simple, convenient to operate, and can quickly synthesize the compounds. Research shows that the indometacin derivative containing 2-amino-1,3,4-thiadiazole has good anti-inflammatory activity and good application prospect in inflammatory diseases.

This invention discloses a dichroic dye with a benzothiadiazole structure, its preparation method, and its application. The dichroic dye is a compound with a general formula (I-a) or (I-b), as follows: The dichroic dye disclosed in this invention has good dichroism and photothermal stability. The disclosed preparation method is characterized by simple operation, low pollution, and high yield, and is particularly suitable for industrial production.

This invention relates to the field of fluorescent probe technology, specifically disclosing a nanoprobe for detecting hydroxyl radicals in living cells, comprising a core and a shell layer. The shell layer is distearylphosphatidylethanolamine-polyethylene glycol 2000, and the core is 4,7-bis(4-(methylthio)phenyl)benzo[c][1,2,5]thiadiazole (BT-S), the structural formula of which is shown in formula (I). This invention also provides a method for preparing this nanoprobe and its applications. The nanoprobe of this invention has the advantages of simple preparation process, stable performance, high detection sensitivity, good specificity, and excellent biocompatibility.