25 results about "Anorexia" patented technology

The present application relates to a kind of traditional Chinese medicine composition for treating pediatric anorexia, the traditional Chinese medicine composition is made of the following weight parts of raw medicinal materials: 7-11 parts of Taizishen, 7-11 parts of Cangzhu, 7-11 parts of Fuling, 7-11 parts of Huoxiang, 7-11 parts of Gegen, 7-11 parts of Qingpi, 6-13 parts of Laiqiezi, 4-8 parts of Lianqiao, 7-11 parts of Sanleng, 7-11 parts of Shanzha.The present application also provides the use of traditional Chinese medicine composition for pediatric anorexia.The present application uses several drugs together, which is integrated with invigorating spleen, transporting spleen and activating spleen, so that the spleen is healthy, the spleen and stomach qi movement is appropriate, and the human body qi movement is adjusted, so that the whole body qi movement is operated, the qi movement is operated, the five internal organs are harmonious, and the whole prescription plays the effect of invigorating spleen and transporting.The total effective rate and the improvement of TCM syndrome score of the traditional Chinese medicine composition of the present application are better than those of the control group, especially in improving the symptoms of anorexia, reduced food intake and other symptoms such as salivation, belching, hiccups, nausea and other symptoms.

The present invention relates to the use of an s100a8 / a9 and complement 3 inhibitor in the preparation of a drug for treating or preventing cachexia. The treatment or prevention of cachexia comprises increasing the body weight, lean body mass and fat mass, and increasing food intake in a cachectic subject, or preventing fat mass consumption, slowing the rate of body weight loss, the rate of fat mass loss and the rate of lean body mass loss, counteracting anorexia, muscle strength loss, fatigue and body weight loss, or improving abnormal biochemical results. Provided is a new understanding for the mechanism of energy balance regulation in cancer cachexia, with an emphasis on the effects of S100a8 / a9 and C3 in cancer cachexia. The inhibition of S100a8 / a9 and complement 3 can promote fat recovery and increase food intake. Particularly, it is verified that an S100a8 / a9 inhibitor can prevent body weight loss, especially adipose tissue loss, in a cachectic subject, and significantly increases food intake in the subject.

Provided herein are methods of treating, preventing, or reducing conditions and / or side effects associated with anti-cancer agents (e.g., chemotherapeutic agents) via administration of a non-naturally occurring melanocortin analog prior to, during, and / or after administration of the anti-cancer agents. The methods reduce adverse effects associated with the anti-cancer agent, such as anorexia, weight loss, muscle mass loss, fat mass loss, wasting, reduced appetite, and loss of appetite, thereby enhancing tolerance of the anti-cancer agents and survival of the subject having cancer or having a disease or condition that is not cancer but is treated, reduced, or prevented by administration of an anti-cancer agent.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating postoperative digestive tract reaction of malignant tumors, a preparation and application. The traditional Chinese medicine composition comprises the following active ingredient raw materials in parts by weight: 10-20 parts of fried codonopsis pilosula, 10-20 parts of fried bighead atractylodes rhizome, 10-20 parts of poria cocos, 1-10 parts of liquorice, 10-20 parts of fried endothelium corneum gigeriae galli, 15-25 parts of fried malt, 25-35 parts of adina rubella hance root, 25-35 parts of wild grape root, 15-25 parts of Chinese actinidia root and 15-25 parts of coix seed. The traditional Chinese medicine composition and the preparation can effectively treat patients with malignant tumor postoperative digestive tract reaction, effectively improve symptoms of abdominal distension, stomachache, nausea, vomiting, diarrhea, constipation, anorexia, sour regurgitation, oral cavity / throat dryness and the like of the patients, improve the life quality of the patients and have good safety.

This invention relates to the use of S100a8 / a9 and complement 3 inhibitors in the preparation of medicaments for the treatment or prevention of cachexia, wherein the treatment or prevention of cachexia involves increasing the body weight, lean body mass, fat mass, and food intake of cachectic subjects, or preventing fat loss, slowing the rate of weight loss, slowing the rate of fat mass loss, slowing the rate of lean body mass loss, resisting anorexia, resisting muscle weakness, resisting fatigue, resisting weight loss, and improving abnormal biochemical results. This invention provides a new understanding of the mechanism of energy balance regulation in cancer cachexia, focusing on the roles of S100a8 / a9 and C3 in cancer cachexia. This invention finds that inhibiting S100a8 / a9 and complement 3 can promote fat recovery and increase food intake. In particular, it demonstrates that S100a8 / a9 inhibitors can prevent the loss of body weight, especially adipose tissue, in cachectic subjects and significantly increase their food intake.

The present invention relates to: a GFRAL-specific antisense oligomer that targets the GDNF family alpha-like receptor (GFRAL) gene; and a pharmaceutical composition for preventing or treating obesity, diabetes, anorexia or cachexia, the pharmaceutical composition comprising the antisense oligomer. It was found that the antisense oligomer according to the present invention effectively inhibits the expression of GFRAL in vivo and exhibits an improved effect in a cancer cachexia animal model. Therefore, by inhibiting the expression of the GFRAL, the antisense oligomer has a wide application prospect as an agent for treating obesity or cachexia.

Provided is a protein-containing food which contains high-quality protein at a high concentration, has excellent taste and flavor, and is suitable as a food for dysphagia patients with inappetence. A protein-containing food according to an embodiment of the present invention contains a collagen peptide, one or more essential amino acids selected from the group consisting of histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine, and water. In the protein-containing food, the water content is 35% by mass or less, and the collagen peptide content is 30% by mass or more.

The invention relates to milk powder for improving child anorexia and a preparation method thereof, which comprises the following steps: putting low-temperature soybean meal as a raw material into a tank, adding 9 times of water at the water temperature of 30-40 DEG C, stirring in the tank, feeding into a high-speed separator, separating soybean dregs, carrying out acid precipitation, separation, neutralization, sterilization and drying treatment on protein water, carrying out low-temperature superfine grinding on dried protein powder by using a superfine grinding machine, and packaging to obtain the milk powder for improving child anorexia. The preparation method comprises the following steps: uniformly mixing whey protein powder, fresh milk, fructo-oligosaccharide, galactooligosaccharide, milk mineral salt, compound trace elements and compound vitamins to obtain a mixed material liquid, and carrying out homogenization, high-pressure homogenization, sterilization, concentration and spray drying on the obtained mixed material liquid to obtain the milk powder. The milk powder, the soybean protein micro powder, the docosahexaenoic acid fish oil powder, the arachidonic acid grease and the composite probiotic powder are uniformly mixed to finally obtain the infant formula milk powder, and the milk powder obtained by the method is quick to dissolve, promotes digestion and has the effects of obviously improving food retention, constipation and anorexia.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with an antiemetic effect and a preparation method thereof. The traditional Chinese medicine composition contains perilla leaf, Coptis chinensis, Amomum villosum, Saussurea lappa, Pinellia ternata, ginger, Chinese yam and honey. The traditional Chinese medicine composition has a good relieving and treating effect on pregnancy vomiting through pharmacological experiments and clinical use verification. The clinical treatment rate of pregnancy vomiting reaches 92.86%, and the traditional Chinese medicine composition can effectively relieve the clinical symptoms of patients, such as nausea and vomiting, dizziness, anorexia, food entering the stomach and then vomiting, and the like. The preparation process is simple, the traditional Chinese medicine composition can be further produced, and has a wide market prospect.

The invention provides a traditional Chinese medicine composition for treating thyroid nodules, which is prepared from twelve medicinal materials including poria cocos, roasted rhizoma atractylodis macrocephalae, rhizoma pinellinae praeparata, honey-fried licorice root, radix bupleuri, radix paeoniae alba, moutan bark, radix scrophulariae, raw oyster shell, vinegar turtle shell, platycodon grandiflorum and semen armeniacae amarae, and a specific process that the raw oyster shell and the vinegar turtle shell are crushed to 3-5mm and then decocted is adopted. According to the treatment principle of tonifying spleen and reducing phlegm, soothing liver and regulating qi, lifting and guiding and softening hardness to dissipate stagnation, platycodon grandiflorum is used for opening and diffusing lung qi carrying medicine to ascend, semen armeniacae amarae is used for depressing qi and reducing phlegm and guiding qi to descend, qi movement thrust of ascending and descending is formed, and the hardness softening medicine can efficiently reach the neck focus; meanwhile, spleen strengthening and healthy energy protection are achieved, and bitter cold is prevented from hurting middle- Through clinical observation of 120 thyroid nodule patients, the total effective rate is 96.7%, the obvious effective rate is 90.0%, pharyngeal foreign body sensation disappears in 7-14 days on average, the nodule volume average reduction rate is 75.8%, the recurrence rate is only 3.3% after 6 months, and the occurrence rate of anorexia and loose stool of the patients is 0%. A contrast experiment further proves that the nodule reduction rate is only 45.5% after the platycodon grandiflorum and the bitter apricot kernels are removed. The traditional Chinese medicine composition can quickly soften and reduce nodules, thoroughly dissolve phlegm stasis, protect healthy qi and reduce relapse, and overcomes the defects of spleen deficiency, excessive phlegm, anorexia, loose stool and drug withdrawal and relapse which are easily caused by traditional bitter and cold prescriptions of selfheal, seaweed and the like.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating persistent pneumonia, the composition is prepared from multiple medicinal materials such as fried hawthorn, areca nut and immature bitter orange, the traditional Chinese medicine composition is prepared by adopting a differential extraction process according to the properties of the medicinal materials, and the two components can be mixed or respectively prepared and combined for use. The traditional Chinese medicine composition adapts to physiological characteristics, can relieve respiratory tract symptoms of the persistent pneumonia, improves systemic symptoms such as low fever and anorexia, and reduces repeated upper respiratory tract infection. The traditional Chinese medicine composition is scientific in compatibility, synergistic in effect, remarkable in curative effect, high in safety and suitable for clinical treatment and body conditioning of the persistent pneumonia, achieves consideration of both symptoms and root causes, can reduce the disease recurrence risk and avoid serious complications, and solves many limitations of an existing treatment scheme.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving gastrointestinal motility disorder and a preparation method thereof, and the traditional Chinese medicine composition is prepared from the following raw materials: fried malt, fried rice sprout, poria cocos, fructus amomi and liquorice. The traditional Chinese medicine composition disclosed by the invention can improve clinical symptoms such as postprandial fullness, early satiety, epigastric pain and epigastric discomfort caused by gastrointestinal motility disorder, epigastric burning feeling and epigastric spasmodic pain; insufficient gastric motility caused by gastrointestinal motility disorder is relieved, and nausea, vomiting, ozostomia, sour regurgitation or bitter regurgitation in the mouth are improved; the traditional Chinese medicine is used for treating weakness of spleen and stomach, and improving the symptoms of poor appetite, anorexia, fatigue, intolerance of cold, cold limbs and sweet excrement caused by stomach cold dull pain, stomach cold distention and fullness, warm and press liking.

The application discloses a longevity tonic and a preparation method thereof, and belongs to the technical field of Chinese herbal medicines. The compound oral liquid is composed of 13 medicinal materials such as yam, fried hawthorn, prepared rehmannia, codonopsis, and poria cocos, adopts a water vapor distillation, double decoction, alcohol precipitation and concentration process, and a stabilizer is added before the decoction liquid is fixed in volume. The stabilizer takes wheat starch as raw material, is subjected to mild enzymolysis through a compound enzyme, is subjected to esterification modification through an acid anhydride compound under the assistance of ultrasonic, is blended with chitosan and biological powder, and is formed into the stabilizer through electrostatic self-assembly. Compared with the prior art, the longevity tonic can significantly inhibit the oxidation and thermal degradation of volatile oil, prolong the shelf life, realize the gastrointestinal slow release of active ingredients, and improve the bioavailability. The longevity tonic is used for treating qi and blood deficiency, regulating the spleen and stomach, and has good effects on old debilitation, post-illness asthenia, fatigue, anorexia, limb pain and numbness, and insomnia and dreaminess.

This invention discloses a method for quantitative feeding of donkeys applied in the field of animal husbandry. This method uses RFID identification technology to open feeding positions, achieving one feeding position per donkey. Based on this, the feeding time, feeding speed, and uneaten amount of each donkey are monitored, and the feeding amount for the next meal is dynamically adjusted. Compared with the prior art, this method can effectively achieve precise feeding of individual donkeys, avoiding feed waste caused by overeating or anorexia. At the same time, the one-donkey-one-feeding method effectively protects the weaker individuals in the donkey herd. Furthermore, by setting the feeding position as a semi-enclosed and independent area, it can not only effectively avoid mutual interference between donkeys during feeding, but also effectively prevent the dominant donkeys from taking the feeding positions of the weaker donkeys after they have finished eating. Physical means can be used to drive away the donkeys that are fighting for food. Compared with the prior art, this method can protect the weaker donkeys that need to be given extra nutrition or medication.

The invention discloses a compound honeysuckle and fingered citron solid beverage and a preparation method thereof, and relates to the field of solid beverages, and the compound honeysuckle and fingered citron solid beverage is mainly prepared from the following raw materials in parts by weight: honeysuckle, fingered citron, lily, whole milk powder, maltodextrin, fruit dry powder and white granulated sugar. The solid beverage disclosed by the invention has good effects of enhancing gastrointestinal motility, improving metabolism and reducing inappetence, and meanwhile, the solid beverage is presented in a solid beverage form and can be eaten anytime and anywhere.

The invention provides a traditional Chinese medicine composition for treating common diseases and symptoms of children and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Active components of the traditional Chinese medicine composition comprise the following raw materials in parts by weight: 5-15 parts of honeysuckle; 5 to 15 parts of fructus forsythiae; 10 to 20 parts of radix isatidis; 5-15 parts of radix scutellariae; 3-10 parts of mint; 3-8 parts of liquorice; 5-15 parts of platycodon grandiflorum; 5-15 parts of herba schizonepetae; 5-15 parts of radix puerariae; 3-10 parts of radix bupleuri; 2-8 parts of cicada slough; 3 to 10 parts of fructus arctii; 5-15 parts of flos farfarae; 5-15 parts of ginger processed pinellia; 5 to 15 parts of oyster; 5-15 parts of bighead atractylodes rhizome; 5-15 parts of radix ophiopogonis; 5-15 parts of fructus cannabis; the compound preparation is optimized and adjusted according to the characteristics of children on the basis of a traditional Chinese medicine prescription, and has unique curative effects on common symptoms such as cold, cough, fever, anorexia, vomiting, diarrhea, constipation and development retardation of children. Vitamin C and vitamin E can also be added into the composition to enhance immunity. The traditional Chinese medicine composition is simple in preparation process, can be prepared into various dosage forms, is suitable for children of different ages, and is remarkable in curative effect, short in onset time, convenient to take, free of toxic and side effects, safe and effective.

The invention discloses a composite liver and kidney protective agent as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The protective agent is prepared from 10%-20% of inosine, 15%-25% of glutamic acid, 10%-15% of cysteine, 15%-20% of glycine, 5%-10% of a coenzyme compound, 10%-20% of small molecule peptide and auxiliary materials. The preparation method comprises the steps of premixing, low-temperature homogenization, spray drying and preparation forming, and uniform distribution of components is ensured through a spray drying technology. The traditional Chinese medicine composition plays a role through a three-stage mechanism of fat removal, repair and regeneration, reduces lipid deposition, scavenges free radicals, repairs hepatocytes and promotes regeneration. The traditional Chinese medicine composition can be used for treating or preventing liver and kidney diseases such as non-alcoholic fatty liver, viral hepatitis and cirrhosis, relieving symptoms such as anorexia, jaundice and bleeding, dispelling the effects of alcohol, protecting the liver and enhancing immunity. The proportion of natural components of the protective agent is more than 80%, the safety is high, multiple targets are synergistic, and the curative effect is superior to that of a single-component medicine.

The application relates to a preparation method of an animal model of pediatric anorexia and application thereof, and belongs to the technical field of medicines. The model can be used for screening of medicines for treating children anorexia, pharmacological research and efficacy evaluation. The application first creatively adopts a modeling method of gradient increment gavage of erythromycin to successfully establish an animal model of children anorexia. The modeling method has the following advantages compared with a conventional high-fat high-protein fat feed feeding and central operation modeling method: modeling time is shortened; compared with other modeling methods, the modeling time cost is reduced by two weeks; economic cost is reduced; compared with high-fat high-protein feed which is relatively expensive, the cost of erythromycin medicine is 1 / 10 of that of the high-fat high-protein feed, and the reduction of time cost also reduces the cost of animal feeding; the operation technology is simple and convenient; compared with the preparation of a high-precision central anorexia animal model, the experimental operation technology is simple; the requirement for laboratory instruments and equipment is relatively low; the demand for experimental personnel is reduced, and the labor cost is reduced.

Provided herein are compositions comprising a non-naturally occurring melanocortin analogue in combination with a spiro compound and / or an antibody or antigen-binding fragment thereof. The composition may further include an anti-cancer agent (e.g., a chemotherapeutic agent). Also provided herein are pharmaceutical compositions incorporating the compositions; methods of using the compositions to modulate weight, including but not limited to increasing appetite, preventing inappetence, promoting weight gain, preventing weight loss, and / or treating, preventing, or otherwise reducing cachexia and / or anorexia in a subject in need thereof.

Methods and compositions for preventing, reducing, delaying, or reversing effects due to aging or preventing, treating, or reducing time to recovery from a disease associated with aging, as well as anemia, hypoalbuminemia, hypocholesterolemia, malnutrition / anorexia / starvation, and / or splenomegaly in a subject in need thereof are disclosed. The method can include administering a therapeutically effective amount of a ketogenic supplement to the subject, wherein the subject is fed ad libitum. The ketogenic supplement can include R,S 1,3-butanediol acetoacetate diester or derivatives thereof.

The invention belongs to the technical field of medicine, and particularly relates to a composition for improving infantile spleen deficiency type anorexia and a preparation method and application thereof.The composition is prepared from, by weight, 40-60% of a five-vitamin lysine oral solution and 40-60% of a traditional Chinese medicine composition, and the traditional Chinese medicine composition is poria cocos and hawthorn paste or ginseng and poria cocos paste; the traditional Chinese medicine composition improves the effect of improving the infantile spleen deficiency type anorexia.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine transdermal patch capable of relieving abdominal distension and promoting appetite and a preparation method. The traditional Chinese medicine transdermal patch is prepared from acrylate pressure-sensitive adhesive, traditional Chinese medicine extracts, a transdermal enhancer and glycerol, wherein the traditional Chinese medicine extracts are prepared from 16 traditional Chinese medicines such as oriental wormwood, semen cassiae, rheum officinale and rhizoma alismatis; an external dosage form is researched and developed on the basis of a stagnation eliminating and liver nourishing prescription, the burden of an oral preparation on gastrointestinal tracts is avoided, and the traditional Chinese medicine composition is suitable for fatty liver patients accompanied by abdominal distension and anorexia. Through the synergistic effect of the transdermal enhancer, the transdermal absorption efficiency and skin retention volume of the traditional Chinese medicine active ingredients can be enhanced, the effects of treating fatty liver, relieving abdominal distension and promoting appetite are achieved, and an external treatment choice with good compliance is provided for clinic.

The invention relates to an externally-applied ointment for treating child anorexia. The externally-applied ointment is prepared from the following traditional Chinese medicines in parts by weight: 6-15 parts of rhizoma atractylodis, 5-15 parts of herba eupatorii, 3-10 parts of pericarpium citri reticulatae, 6-15 parts of rhizoma pinelliae preparata, 6-12 parts of fructus aurantii, 5-15 parts of agastache rugosus, 10-15 parts of coked medicated leaven and 10-15 parts of roasted malt. The external application ointment is safe in clinical use, has a remarkable treatment effect on child anorexia, can obviously improve the appetite and digestive function of child patients, does not need to be orally taken, and is good in child patient compliance.

The application discloses a traditional Chinese medicine composition for pregnancy reaction, which is prepared from raw materials in the following weight ratio: cyperus rotundus 10-20 parts, radix scrophulariae 10-20 parts, pinellia ternata 10-20 parts, radix paeoniae alba 5-20 parts, agastache rugosus 5-15 parts, syzygium aromaticum 5-15 parts and zingiber officinale 5-15 parts. The raw materials are matched precisely, and the traditional Chinese medicine composition has the effects of soothing liver and stomach, regulating qi, reducing phlegm, stopping vomiting, strengthening spleen and benefiting qi, and protecting fetus, and can obviously improve the pregnancy reaction symptoms of incoordination between liver and stomach, spleen deficiency and phlegm obstruction, such as nausea and vomiting, dry mouth and bitter taste or mouth-foaming phlegm, chest fullness and hypochondriac pain, abdominal distension, belching, fatigue, dizziness and anorexia, and can prevent recurrence and prevent common pregnancy vomiting from developing into severe pregnancy vomiting, and has high practical application value.

The invention relates to a nutritional composition for preventing and / or treating cancerous cachexia, and belongs to the technical field of biology. The invention provides a nutritional composition for preventing and / or treating cancerous cachexia. The composition comprises the following components: maltodextrin, solid corn syrup, fructo-oligosaccharide, galactooligosaccharide, whey protein, arginine, glutamine, fish oil, medium chain triglyceride, sunflower seed oil, linseed oil, compound macro minerals, compound vitamins and compound trace minerals. The composition not only can effectively improve adverse reactions caused by treatment, but also can comprehensively supplement key nutrients required for improving skeletal muscle states of tumor patients and promoting immune repair, accurately makes up for nutrition loss caused by disease consumption and treatment side effects of the tumor patients, relieves metabolic disorder and skeletal muscle consumption, and improves the curative effect of the tumor patients. The traditional Chinese medicine composition can improve physiological and immune functions of the body, relieve fatigue, anorexia and other symptoms, reduce the level of proinflammatory cytokines, improve body vitality and reduce the risk of treatment interruption.