14 results about "Anorexia" patented technology

The present invention relates to the use of an s100a8 / a9 and complement 3 inhibitor in the preparation of a drug for treating or preventing cachexia. The treatment or prevention of cachexia comprises increasing the body weight, lean body mass and fat mass, and increasing food intake in a cachectic subject, or preventing fat mass consumption, slowing the rate of body weight loss, the rate of fat mass loss and the rate of lean body mass loss, counteracting anorexia, muscle strength loss, fatigue and body weight loss, or improving abnormal biochemical results. Provided is a new understanding for the mechanism of energy balance regulation in cancer cachexia, with an emphasis on the effects of S100a8 / a9 and C3 in cancer cachexia. The inhibition of S100a8 / a9 and complement 3 can promote fat recovery and increase food intake. Particularly, it is verified that an S100a8 / a9 inhibitor can prevent body weight loss, especially adipose tissue loss, in a cachectic subject, and significantly increases food intake in the subject.

Provided herein are methods of treating, preventing, or reducing conditions and / or side effects associated with anti-cancer agents (e.g., chemotherapeutic agents) via administration of a non-naturally occurring melanocortin analog prior to, during, and / or after administration of the anti-cancer agents. The methods reduce adverse effects associated with the anti-cancer agent, such as anorexia, weight loss, muscle mass loss, fat mass loss, wasting, reduced appetite, and loss of appetite, thereby enhancing tolerance of the anti-cancer agents and survival of the subject having cancer or having a disease or condition that is not cancer but is treated, reduced, or prevented by administration of an anti-cancer agent.

This invention relates to the use of S100a8 / a9 and complement 3 inhibitors in the preparation of medicaments for the treatment or prevention of cachexia, wherein the treatment or prevention of cachexia involves increasing the body weight, lean body mass, fat mass, and food intake of cachectic subjects, or preventing fat loss, slowing the rate of weight loss, slowing the rate of fat mass loss, slowing the rate of lean body mass loss, resisting anorexia, resisting muscle weakness, resisting fatigue, resisting weight loss, and improving abnormal biochemical results. This invention provides a new understanding of the mechanism of energy balance regulation in cancer cachexia, focusing on the roles of S100a8 / a9 and C3 in cancer cachexia. This invention finds that inhibiting S100a8 / a9 and complement 3 can promote fat recovery and increase food intake. In particular, it demonstrates that S100a8 / a9 inhibitors can prevent the loss of body weight, especially adipose tissue, in cachectic subjects and significantly increase their food intake.

The invention relates to milk powder for improving child anorexia and a preparation method thereof, which comprises the following steps: putting low-temperature soybean meal as a raw material into a tank, adding 9 times of water at the water temperature of 30-40 DEG C, stirring in the tank, feeding into a high-speed separator, separating soybean dregs, carrying out acid precipitation, separation, neutralization, sterilization and drying treatment on protein water, carrying out low-temperature superfine grinding on dried protein powder by using a superfine grinding machine, and packaging to obtain the milk powder for improving child anorexia. The preparation method comprises the following steps: uniformly mixing whey protein powder, fresh milk, fructo-oligosaccharide, galactooligosaccharide, milk mineral salt, compound trace elements and compound vitamins to obtain a mixed material liquid, and carrying out homogenization, high-pressure homogenization, sterilization, concentration and spray drying on the obtained mixed material liquid to obtain the milk powder. The milk powder, the soybean protein micro powder, the docosahexaenoic acid fish oil powder, the arachidonic acid grease and the composite probiotic powder are uniformly mixed to finally obtain the infant formula milk powder, and the milk powder obtained by the method is quick to dissolve, promotes digestion and has the effects of obviously improving food retention, constipation and anorexia.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with an antiemetic effect and a preparation method thereof. The traditional Chinese medicine composition contains perilla leaf, Coptis chinensis, Amomum villosum, Saussurea lappa, Pinellia ternata, ginger, Chinese yam and honey. The traditional Chinese medicine composition has a good relieving and treating effect on pregnancy vomiting through pharmacological experiments and clinical use verification. The clinical treatment rate of pregnancy vomiting reaches 92.86%, and the traditional Chinese medicine composition can effectively relieve the clinical symptoms of patients, such as nausea and vomiting, dizziness, anorexia, food entering the stomach and then vomiting, and the like. The preparation process is simple, the traditional Chinese medicine composition can be further produced, and has a wide market prospect.

The invention provides a traditional Chinese medicine composition for treating thyroid nodules, which is prepared from twelve medicinal materials including poria cocos, roasted rhizoma atractylodis macrocephalae, rhizoma pinellinae praeparata, honey-fried licorice root, radix bupleuri, radix paeoniae alba, moutan bark, radix scrophulariae, raw oyster shell, vinegar turtle shell, platycodon grandiflorum and semen armeniacae amarae, and a specific process that the raw oyster shell and the vinegar turtle shell are crushed to 3-5mm and then decocted is adopted. According to the treatment principle of tonifying spleen and reducing phlegm, soothing liver and regulating qi, lifting and guiding and softening hardness to dissipate stagnation, platycodon grandiflorum is used for opening and diffusing lung qi carrying medicine to ascend, semen armeniacae amarae is used for depressing qi and reducing phlegm and guiding qi to descend, qi movement thrust of ascending and descending is formed, and the hardness softening medicine can efficiently reach the neck focus; meanwhile, spleen strengthening and healthy energy protection are achieved, and bitter cold is prevented from hurting middle- Through clinical observation of 120 thyroid nodule patients, the total effective rate is 96.7%, the obvious effective rate is 90.0%, pharyngeal foreign body sensation disappears in 7-14 days on average, the nodule volume average reduction rate is 75.8%, the recurrence rate is only 3.3% after 6 months, and the occurrence rate of anorexia and loose stool of the patients is 0%. A contrast experiment further proves that the nodule reduction rate is only 45.5% after the platycodon grandiflorum and the bitter apricot kernels are removed. The traditional Chinese medicine composition can quickly soften and reduce nodules, thoroughly dissolve phlegm stasis, protect healthy qi and reduce relapse, and overcomes the defects of spleen deficiency, excessive phlegm, anorexia, loose stool and drug withdrawal and relapse which are easily caused by traditional bitter and cold prescriptions of selfheal, seaweed and the like.

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating persistent pneumonia, the composition is prepared from multiple medicinal materials such as fried hawthorn, areca nut and immature bitter orange, the traditional Chinese medicine composition is prepared by adopting a differential extraction process according to the properties of the medicinal materials, and the two components can be mixed or respectively prepared and combined for use. The traditional Chinese medicine composition adapts to physiological characteristics, can relieve respiratory tract symptoms of the persistent pneumonia, improves systemic symptoms such as low fever and anorexia, and reduces repeated upper respiratory tract infection. The traditional Chinese medicine composition is scientific in compatibility, synergistic in effect, remarkable in curative effect, high in safety and suitable for clinical treatment and body conditioning of the persistent pneumonia, achieves consideration of both symptoms and root causes, can reduce the disease recurrence risk and avoid serious complications, and solves many limitations of an existing treatment scheme.

The application discloses a longevity tonic and a preparation method thereof, and belongs to the technical field of Chinese herbal medicines. The compound oral liquid is composed of 13 medicinal materials such as yam, fried hawthorn, prepared rehmannia, codonopsis, and poria cocos, adopts a water vapor distillation, double decoction, alcohol precipitation and concentration process, and a stabilizer is added before the decoction liquid is fixed in volume. The stabilizer takes wheat starch as raw material, is subjected to mild enzymolysis through a compound enzyme, is subjected to esterification modification through an acid anhydride compound under the assistance of ultrasonic, is blended with chitosan and biological powder, and is formed into the stabilizer through electrostatic self-assembly. Compared with the prior art, the longevity tonic can significantly inhibit the oxidation and thermal degradation of volatile oil, prolong the shelf life, realize the gastrointestinal slow release of active ingredients, and improve the bioavailability. The longevity tonic is used for treating qi and blood deficiency, regulating the spleen and stomach, and has good effects on old debilitation, post-illness asthenia, fatigue, anorexia, limb pain and numbness, and insomnia and dreaminess.

This invention discloses a method for quantitative feeding of donkeys applied in the field of animal husbandry. This method uses RFID identification technology to open feeding positions, achieving one feeding position per donkey. Based on this, the feeding time, feeding speed, and uneaten amount of each donkey are monitored, and the feeding amount for the next meal is dynamically adjusted. Compared with the prior art, this method can effectively achieve precise feeding of individual donkeys, avoiding feed waste caused by overeating or anorexia. At the same time, the one-donkey-one-feeding method effectively protects the weaker individuals in the donkey herd. Furthermore, by setting the feeding position as a semi-enclosed and independent area, it can not only effectively avoid mutual interference between donkeys during feeding, but also effectively prevent the dominant donkeys from taking the feeding positions of the weaker donkeys after they have finished eating. Physical means can be used to drive away the donkeys that are fighting for food. Compared with the prior art, this method can protect the weaker donkeys that need to be given extra nutrition or medication.

The invention provides a traditional Chinese medicine composition for treating common diseases and symptoms of children and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Active components of the traditional Chinese medicine composition comprise the following raw materials in parts by weight: 5-15 parts of honeysuckle; 5 to 15 parts of fructus forsythiae; 10 to 20 parts of radix isatidis; 5-15 parts of radix scutellariae; 3-10 parts of mint; 3-8 parts of liquorice; 5-15 parts of platycodon grandiflorum; 5-15 parts of herba schizonepetae; 5-15 parts of radix puerariae; 3-10 parts of radix bupleuri; 2-8 parts of cicada slough; 3 to 10 parts of fructus arctii; 5-15 parts of flos farfarae; 5-15 parts of ginger processed pinellia; 5 to 15 parts of oyster; 5-15 parts of bighead atractylodes rhizome; 5-15 parts of radix ophiopogonis; 5-15 parts of fructus cannabis; the compound preparation is optimized and adjusted according to the characteristics of children on the basis of a traditional Chinese medicine prescription, and has unique curative effects on common symptoms such as cold, cough, fever, anorexia, vomiting, diarrhea, constipation and development retardation of children. Vitamin C and vitamin E can also be added into the composition to enhance immunity. The traditional Chinese medicine composition is simple in preparation process, can be prepared into various dosage forms, is suitable for children of different ages, and is remarkable in curative effect, short in onset time, convenient to take, free of toxic and side effects, safe and effective.

Provided herein are compositions comprising a non-naturally occurring melanocortin analogue in combination with a spiro compound and / or an antibody or antigen-binding fragment thereof. The composition may further include an anti-cancer agent (e.g., a chemotherapeutic agent). Also provided herein are pharmaceutical compositions incorporating the compositions; methods of using the compositions to modulate weight, including but not limited to increasing appetite, preventing inappetence, promoting weight gain, preventing weight loss, and / or treating, preventing, or otherwise reducing cachexia and / or anorexia in a subject in need thereof.

Methods and compositions for preventing, reducing, delaying, or reversing effects due to aging or preventing, treating, or reducing time to recovery from a disease associated with aging, as well as anemia, hypoalbuminemia, hypocholesterolemia, malnutrition / anorexia / starvation, and / or splenomegaly in a subject in need thereof are disclosed. The method can include administering a therapeutically effective amount of a ketogenic supplement to the subject, wherein the subject is fed ad libitum. The ketogenic supplement can include R,S 1,3-butanediol acetoacetate diester or derivatives thereof.

The invention relates to an externally-applied ointment for treating child anorexia. The externally-applied ointment is prepared from the following traditional Chinese medicines in parts by weight: 6-15 parts of rhizoma atractylodis, 5-15 parts of herba eupatorii, 3-10 parts of pericarpium citri reticulatae, 6-15 parts of rhizoma pinelliae preparata, 6-12 parts of fructus aurantii, 5-15 parts of agastache rugosus, 10-15 parts of coked medicated leaven and 10-15 parts of roasted malt. The external application ointment is safe in clinical use, has a remarkable treatment effect on child anorexia, can obviously improve the appetite and digestive function of child patients, does not need to be orally taken, and is good in child patient compliance.

The application discloses a traditional Chinese medicine composition for pregnancy reaction, which is prepared from raw materials in the following weight ratio: cyperus rotundus 10-20 parts, radix scrophulariae 10-20 parts, pinellia ternata 10-20 parts, radix paeoniae alba 5-20 parts, agastache rugosus 5-15 parts, syzygium aromaticum 5-15 parts and zingiber officinale 5-15 parts. The raw materials are matched precisely, and the traditional Chinese medicine composition has the effects of soothing liver and stomach, regulating qi, reducing phlegm, stopping vomiting, strengthening spleen and benefiting qi, and protecting fetus, and can obviously improve the pregnancy reaction symptoms of incoordination between liver and stomach, spleen deficiency and phlegm obstruction, such as nausea and vomiting, dry mouth and bitter taste or mouth-foaming phlegm, chest fullness and hypochondriac pain, abdominal distension, belching, fatigue, dizziness and anorexia, and can prevent recurrence and prevent common pregnancy vomiting from developing into severe pregnancy vomiting, and has high practical application value.