82 results about "Have Nausea" patented technology

The invention discloses an anesthesia reviving room risk assessment system for postoperative nausea and vomiting prediction, relates to the technical field of postoperative nausea and vomiting prediction, and aims to perform multi-modal fusion on clinical features of a patient and brain function signals to realize basic probability calculation of postoperative nausea and vomiting risks, and introduce real-time dynamic physiological parameters as regulatory factors to realize postoperative nausea and vomiting risk prediction. And performing adaptive adjustment on the basic prediction result to generate a comprehensive risk probability value. The system can collect and process data in real time after a patient enters an anesthesia reviving room, and dynamic and personalized risk assessment is achieved. Compared with a traditional scoring method which only depends on static clinical features, the method has the advantages that tiny fluctuation of the postoperative physiological state of the patient can be captured, prediction precision and timeliness can be improved, clear decision support can be provided for nursing staff, and therefore preventive intervention measures are optimized, and the occurrence rate of complications is reduced.

The invention relates to the technical field of intelligent nursing, in particular to an intelligent nursing intervention system and method for nausea and vomiting after a pulmonary operation. The analysis of nausea and vomiting performance is established on the basis of continuous and quantifiable indexes, the sensitivity of judging a risk trend is improved, a risk change path is identified through a long-short-term memory neural network, an influence rule of intervention intensity on a nausea and vomiting evolution trend is accurately described, stage prediction of a nursing intervention effect is realized, and the risk prediction accuracy is improved. Structural optimization is performed on an intervention time sequence and nursing task allocation and execution rhythm through a convolutional neural network, an intervention rhythm path is recombined in combination with resource adaptation information, the coverage density of intervention measures for risk periods is enhanced, integrated response of nursing resources in a high-sensitivity interval is promoted, and synchronous optimization of task allocation and time sequence matching is realized.

Nausea and vomiting are unpleasant events caused by a variety of triggering factors. Wherein medicines often cause nausea and vomiting. An anti-tumor chemotherapeutic agent is one of the most emetic drugs, and often causes chemotherapy-induced nausea and vomiting (CINV). The latter seriously impairs the therapeutic effect and the quality of life of the patient. It is of great interest in determining agents capable of preventing and combating drug-induced nausea and vomiting, including CINV. A calcitonin gene-related peptide (CGRP) is a neuropeptide having various effects in a human body. However, neuropeptide effects in the brain are still to be clarified. CGRP receptor antagonists (named as gezepam) have been recently approved for use in the treatment of migraine. The use of gezepams for the direct treatment of nausea and vomiting, including CINV, is described.

Provided are methods for the treatment of SCLC patients by administering therapeutic amounts of lurbinectedin by intravenous infusion. Also provided are methods of treating cancer by administering lurbinectedin in combination with other anticancer drugs, in particular topoisomerase inhibitors. The invention further relates to the administration of lurbinectedin in combination with anti-emetic agents for effective control of symptoms related to nausea and vomiting, reduced lurbinectedin dosages to achieve a safer administration and an increase in the number of treatment cycles. Stable lyophilized formulations of lurbinectedin are also provided.

A Limosilactobacillus fermentum strain capable of alleviating a hangover and the use thereof. The strain is at least one strain of Limosilactobacillus fermentum ibiome020, Limosilactobacillus fermentum ibiome021 and Limosilactobacillus fermentum ibiome022 respectively deposited with deposit numbers of CCTCC NO: M 2024188, CCTCC NO: M 2024222 and CCTCC NO: M 2024189. The Limosilactobacillus fermentum is a natural bacterium derived from the intestine of a healthy human and has high safety; can alleviate chronic / acute alcoholism, alcoholic intestinal damage or alcoholic liver damage; can accelerate the metabolism of ethanol and / or acetaldehyde, and delay the onset of intoxication; can shorten the sobering-up time; can reduce the mortality caused by drinking alcohol; can reduce the liver index; can lower the level of AST and / or ALT in serum; can alleviate discomfort caused by ethanol and / or acetaldehyde, and mitigate symptoms such as dizziness, headache, nausea and vomiting, and hangover after drinking alcohol; can ameliorate oxidative stress caused by alcohol, and increase the level of GSH in the liver; and also has excellent resistance to gastrointestinal fluid and bile salt, and can adapt to the complex environment within the body.

The invention relates to the technical field of ginger moxibustion, in particular to a portable temperature-controllable ginger moxibustion device for arresting vomiting of tumor patients, which comprises a shell, a tube is fixedly connected to the inner side wall of the shell, a pore plate is fixedly connected to the bottom of the tube, a temperature sensor is mounted on the inner side wall of the tube, and a cover is in threaded connection to the top of the shell. A cylinder is fixedly connected to the bottom of the cover body, and an electric heating rod is mounted at the bottom of the cylinder; the electric heating rod is used for simulating heating power of moxa in traditional ginger-separated moxibustion, controllable heating power is used for exciting drug efficacy of ginger of ginger slices on the pore plate, the synergistic effect mechanism that ginger penetrates through heating power and drug efficacy enters the acupoint is perfectly rescribed, the device is designed according to the core requirement of descending adverse-rising energy and arresting vomiting of tumor patients, the device can accurately act on related acupoints for arresting vomiting, and the effect is achieved. The symptoms of nausea and vomiting caused by chemoradiotherapy and the like are effectively relieved.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating postoperative digestive tract reaction of malignant tumors, a preparation and application. The traditional Chinese medicine composition comprises the following active ingredient raw materials in parts by weight: 10-20 parts of fried codonopsis pilosula, 10-20 parts of fried bighead atractylodes rhizome, 10-20 parts of poria cocos, 1-10 parts of liquorice, 10-20 parts of fried endothelium corneum gigeriae galli, 15-25 parts of fried malt, 25-35 parts of adina rubella hance root, 25-35 parts of wild grape root, 15-25 parts of Chinese actinidia root and 15-25 parts of coix seed. The traditional Chinese medicine composition and the preparation can effectively treat patients with malignant tumor postoperative digestive tract reaction, effectively improve symptoms of abdominal distension, stomachache, nausea, vomiting, diarrhea, constipation, anorexia, sour regurgitation, oral cavity / throat dryness and the like of the patients, improve the life quality of the patients and have good safety.

The GIP receptor agonists of this disclosure have antiemetic properties and can therefore be used to reduce or inhibit the frequency or severity of episodes of nausea or vomiting in patients in need.

The utility model discloses a tumor patient nausea and vomiting evaluation device, and particularly relates to the technical field of tumor patient nausea and vomiting evaluation, the tumor patient nausea and vomiting evaluation, the tumor patient nausea and vomiting evaluation device comprises a digital scoring ruler and a facial expression scoring ruler, the bottom end of the digital scoring ruler is provided with a cavity adapted to the sliding placement of the facial expression scoring ruler, and the side end of the facial expression scoring ruler is provided with an accommodating groove; and rolling wheels are rotationally mounted in the accommodating grooves and are in rolling fit with the side walls of the cavities. According to the device, the facial expression scoring ruler is arranged in the digital scoring ruler in a sleeving manner, so that the device is convenient for medical staff to carry and also convenient for the medical staff to select an evaluation tool which is most suitable for a patient to use.

The invention discloses a traditional Chinese medicine composition for treating nausea and / or vomiting, which is prepared from the following traditional Chinese medicines in parts by weight: 8-10 parts of radix paeoniae alba, 2-6 parts of rheum officinale, 2-6 parts of lindera aggregata and 2-4 parts of liquorice. The traditional Chinese medicine composition is reasonable in formula and clear in monarch, minister, assistant and guide, has the effects of strengthening the spleen, harmonizing the stomach, calming the adverse-rising energy and arresting vomiting, and is suitable for various symptoms of nausea and / or vomiting. Clinical research proves that the traditional Chinese medicine composition can remarkably improve the cure rate and shorten the cure time, is high in total effective rate and good in safety, and has good clinical significance.

Compositions and methods for the control and treatment of obesity, metabolic disorders, nausea and vomiting using ODN peptides and synthetic derivatives thereof are disclosed.

The present invention relates to an oily composition comprising maropitant and an oily carrier. The invention also relates to the use of such a composition in the treatment and prevention of nausea and vomiting in a non-human mammal, in particular a dog or cat.

This invention relates to an azabicyclo[3.1.0]hexane derivative that can be used as a 3C-like protease inhibitor. This azabicyclo[3.1.0]hexane derivative can be used to treat fever, nausea, vomiting, headache, dyspnea, fatigue, respiratory tract infection, olfactory and gustatory disturbances and their complications, or combinations thereof, caused by novel coronavirus infection.

The invention relates to the technical field of biological medicine, in particular to a medicine solution composition, a preparation method thereof, a nasal spray and application. The medicine solution composition comprises a medicine active component, an osmotic pressure regulator, a pH regulator and water. The active pharmaceutical ingredient comprises ondansetron or a pharmaceutically acceptable salt of ondansetron. The medicine solution composition provided by the invention can be quickly absorbed into blood through nasal mucosa, reaches a peak within 5-10 minutes after being administered through nasal spray administration, is expected to take effect quickly, can help a patient to deal with nausea and vomiting caused by cytotoxic chemotherapy and radiotherapy in time and be used for preventing postoperative nausea and vomiting (PONV), and is good in stability.

The present invention relates to a pharmaceutical composition comprising a fixed dose combination of (a) netupitant, or a salt or hydrate thereof, and (b) palonosetron, or a salt or hydrate thereof, in a single pharmaceutical unit. The invention further relates to a method for preparing a pharmaceutical composition in the form of a tablet, the method comprises: (i) wet granulating a dry mixture comprising netupitant or a salt or hydrate thereof, a filler, a binder, a disintegrant, and optionally a surfactant and / or a lubricant, with a solution comprising palonosetron or a salt or hydrate thereof, and optionally a surfactant and / or a binder, to produce granules; (ii) blending the particles with a lubricant, a disintegrant and a glidant, and optionally a filler, and (iii) compacting the lubricated particles to produce a tablet. The invention further relates to the use of said pharmaceutical composition for the treatment and / or prevention of nausea and / or vomiting, preferably for the treatment and / or prevention of acute or delayed nausea and vomiting associated with chemotherapy, such as highly or moderately emetically induced cancer chemotherapy, such as cis-platinum cancer chemotherapy.

This invention provides a method for treating postoperative nausea and vomiting using buccal acupuncture combined with a triple antiemetic regimen. The method employs a combined intervention of buccal acupuncture and a triple antiemetic regimen. The triple regimen consists of a 5-HT3 receptor antagonist, a glucocorticoid, and a dopamine receptor antagonist, administered intravenously in two separate doses. The buccal acupuncture uses CA-2 (upper jiao), CA-3 (middle jiao), and CA-4 (lower jiao) as core acupoints, with auxiliary and reinforcing acupoints added based on the surgical site and high-risk groups. A standardized procedure of pecking stimulation is applied, along with a corresponding postoperative remedial antiemetic medication regimen. This invention organically combines multi-target drug blockade with buccal acupuncture's visceral regulation, synergistically enhancing the antiemetic effect, reducing the incidence of nausea and vomiting, and decreasing the need for remedial medication. The regimen is highly standardized, widely adaptable, and can meet the postoperative nausea and vomiting control needs of various surgeries and high-risk groups. It exhibits good safety, strong repeatability, and high clinical application value.

The present disclosure relates generally to methods of treating, preventing, or reducing nausea, vomiting, or a combination thereof, hyperemesis gravidarum (HG), nausea gravidarum and vomiting (NVP), or sequelae thereof in a human subject in need thereof, the methods comprise administering to the human subject a therapeutically effective amount of an antibody that specifically binds to a human glial cell line derived neurotrophic factor family receptor alpha-like (GFRAL).

A method in which gepants (antagonists of calcitonin gene related peptide (CGRP) receptor) are used for direct treatment of nausea and vomiting including chemotherapy-induced nausea and vomiting (CINV). Among them, drugs frequently prompt nausea and vomiting, such as antitumor chemotherapeutics which often cause CINV which in turn can severely compromise efficacy of therapy, as well as patient quality of life. The method uses antagonists of the CGRP receptor recently approved for migraine treatment to target calcitonin gene related peptide (CGRP), a neuropeptide with pleiotypic effects in the human body to prevent and counteract drug-induced nausea and vomiting including CINV.

Methods and compositions comprising carotenoids for the treatment or prevention of nausea, e.g., chemotherapy-induced nausea and vomiting.

This invention belongs to the field of traditional Chinese medicine technology, and relates to a topical Chinese medicine composition, topical drug, topical patch, acupoint patch, and preparation method and application for treating nausea and vomiting caused by chemotherapy for intracranial tumors. The Chinese medicine composition consists of the following raw materials in parts by weight: 1-2 parts of Ligusticum chuanxiong, 1-2 parts of Gastrodia elata, 2-4 parts of Uncaria rhynchophylla, 1-2 parts of Citrus aurantium, 1-2 parts of Sinapis alba, 1-2 parts of Clematis chinensis, 0.5-1 part of Melia toosendan, 0.5-1 part of Panax ginseng, 1-2 parts of Pinellia ternata, 1-2 parts of Albizia julibrissin bark, 0.5-1 part of Lentinus edodes, and 1-2 parts of Astragalus membranaceus. This Chinese medicine composition has the effects of relieving nausea and vomiting, soothing the liver and strengthening the spleen, detoxifying and eliminating turbidity, calming the liver and extinguishing wind, and calming the mind and soothing the nerves. It not only effectively controls the nausea and vomiting symptoms caused by chemotherapy for intracranial tumors, but also harmonizes the body's Qi and organ functions. The Chinese medicine composition has a simple formula, widely available ingredients, and a simple preparation method; it is for topical application, convenient for clinical use, and has low adverse reactions.

The invention discloses application of a compound containing a dibenzofuran structure in preparation of a medicine for preventing and / or treating nausea and vomiting, and relates to the technical field of medicinal chemistry. The invention provides application of a compound containing a dibenzofuran structure in preparation of a medicine for preventing and / or treating nausea and vomiting, the molecular formula of the compound is C19H11ClN2O4, and the CAS number is 328255-08-9. The compound can effectively reduce the number of times of canine retching and vomiting caused by cis-platinum, has an effect superior to that of metoprazole, has the potential of preventing and / or vomiting caused by chemotherapy, and has an application prospect in development of drugs for treating vomiting caused by chemotherapy drugs.

The invention belongs to the technical field of medicine preparation, and particularly relates to a composition for relieving nausea and vomiting symptoms caused by chemotherapy and application of the composition. 38-42 parts of lily, 25-30 parts of black dates, 17-23 parts of herba violae, 15-19 parts of pumpkins, 9-13 parts of fructus gardeniae and 5-10 parts of flaxseeds are specifically combined, all the raw materials can achieve a synergistic effect, gastrointestinal mucosa is protected, irritation of chemotherapeutic drugs to gastrointestinal tracts is reduced, and the occurrence rate of vomiting is reduced; in addition, the raw materials can regulate the immune function of the body, enhance the resistance of the body and relieve the adverse effect of chemotherapeutic drugs on the body, so that vomiting is indirectly relieved. Therefore, the composition provided by the invention can be used for preparing products for relieving nausea and vomiting symptoms caused by chemotherapy, the preparation method is simple and convenient, the vomiting symptoms can be prevented and treated in a targeted manner, and the pain of patients is greatly relieved.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a navel therapy composition and a navel therapy preparation for preventing and treating abdominal pain caused by intravenous drip of azithromycin in children and a preparation method of the navel therapy composition and the navel therapy preparation. The technical key points are as follows: the fructus evodiae and the dysentery are combined according to a specific weight ratio, and are matched with pharmaceutic adjuvants such as a transdermal enhancer and an excipient to prepare special navel therapy dosage forms such as pills, cakes, patches and the like. According to the composition, by utilizing the characteristics that the Shenque acupoint (navel) epidermal cuticle is thin, the barrier function is weak, blood vessels are rich, and medicines are easy to disperse and absorb, adverse reactions such as gastrointestinal spasmodic pain, nausea and vomiting and the like caused by intravenous drip of azithromycin in children are effectively relieved through an administration mode of external application. Through clinical verification, the umbilical therapy preparation can remarkably reduce the incidence rate and severity score of stomachache, vomiting and diarrhea, and remarkably improve the treatment compliance of child patients.

To provide a technique relating to treatment of nausea and / or vomiting.SOLUTION: Administering to a subject in need thereof a therapeutically effective amount of a C50 carotenoids compound. The C50 carotenoids compound is selected from the group consisting of decaprenoxanthin, C50 - astaxanthin, C50 - beta-carotene, C50 - carotene (n = 3) (1616 - diisopentenylphytoene), C50 - zeaxanthin, C50 - caroxanthin, C50 - nostoxanthin, sarsinaxanthin, sarprenoxanthin, acyclic C50 carotenoids bacterioruberin, C50 - canthaxanthin, - lycopene, - phytoene, and combinations thereof. C50 C50.SELECTED DRAWING: Figure 1A

The GIP receptor agonists of the present disclosure have antiemetic properties and thus may be used to reduce or inhibit the frequency or severity of nausea or vomiting onset in a patient in need thereof.

Provided are methods for the treatment of SCLC patients by administering therapeutic amounts of lurbinectedin by intravenous infusion. Also provided are methods of treating cancer by administering lurbinectedin in combination with other anticancer drugs, in particular topoisomerase inhibitors. The invention further relates to the administration of lurbinectedin in combination with anti-emetic agents for effective control of symptoms related to nausea and vomiting, reduced lurbinectedin dosages to achieve a safer administration and an increase in the number of treatment cycles. Stable lyophilized formulations of lurbinectedin are also provided.

The present application relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has an effect of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis, and lowering triglyceride levels.

The present application discloses pharmaceutical compositions for modified release of huperzine. The pharmaceutical compositions and methods described herein, allow for dosing of huperzine at higher therapeutic thresholds, while avoiding rapid serum peak plasma levels, thereby avoiding the adverse nausea and vomiting associated with the immediate release pharmaceutical compositions. Methods of treating neurological disorders and / or seizure disorders with the modified release compositions is also described.

The invention discloses anti-vomiting hydrolyzed whey protein and a preparation method thereof, and belongs to the technical field of food processing. The product provided by the invention reduces the digestion burden of protein and relieves the symptom of vomiting. According to the method disclosed by the invention, protein sequences are mutually crosslinked by virtue of a treatment mode of first fibration, second polymerization and final hydrolysis, and a hydrolyzed polypeptide sequence is changed, so that the abundance of the polypeptide SLAMAASDISLA in a hydrolysate is improved. The polypeptide has the characteristics of being easy to recognize by intestinal peptidase and relatively high in PepT1 affinity, the bioavailability of protein is improved, and the deamination proportion of unutilized amino acid is reduced, so that substances generating nitrogen-containing toxoid are reduced, the stimulation of toxin accumulation on gastrointestinal mucosa is relieved, and the symptoms of nausea, vomiting and the like of a user are avoided.