127 results about "Have Nausea" patented technology

Extended release ondansetron compositions of the present invention are useful for treating postoperative nausea and vomiting (PONV) and/or postdischarge nausea and vomiting (PDNV).

Belonging to the field of medical technologies, the invention specifically relates to a tropisetron hydrochloride compound. The invention also relates to application of an injection containing the tropisetron hydrochloride compound in the crystal form of the invention in preparing medicaments for treating nausea and vomiting.

The invention discloses a new traditional Chinese medicine compound for treating intestinal abscess and a preparation method thereof, wherein the traditional Chinese medicine compound of the invention mainly comprises the following raw material medicines: rhizoma coptidis, fresh rehmannia root, figwort, kudzu vine root, red paeonia, root of herbaceous peony, china root, honeysuckle, dandelion, Chinese violet, Chinese lobelia, satrwort root, rhizoma cyperi, fruit of immature citron, tambac, dalbergia wood, Szchuan lovage rhizome, fried fumitory, fried frankincense, fried myrrh, salvia miltiorrhiza, woodlouse, dragon's blood and the like. The traditional Chinese medicine compound of the invention can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can markedly improve the symptoms of QI stagnation and blood stasis, stomachache or periumbilical pain, fever with chilliness, nausea and vomiting, excessive noxious heat, tense abdomen, tenderness, local lump, spontaneous perspiration due to high fever and the like, and has exact clinical curative effect, remarkable curative effect and rapid effect taking. Because the traditional Chinese medicine compound of the invention is combined by basically adopting medicine-food homologous medicaments specified in National Formulary, the traditional Chinese medicine compound has the advantages of low cost, basically no toxic or side effect and the like.

The invention relates to an oral spray for controlling nausea and vomit of chemotherapy and radiation therapy, the formula of the oral spray is composed of ingredients with the following parts by weight: 5-50 parts of drug absorption enhancer, 2-20 parts of drug active ingredient and 30-90 parts of buffer, the drug absorption enhancer can be any one or the combination of more of the following ingredients: azone, propylene glycol, polysorbate (Tween), ethylene glycol deoxycholic acid sodium salt, brij, sodium decanoate, lauric acid, stearic acid, sodium lauryl sulphate, stearyl alcohol sodium sulfate, dioctyl succinate sodium sulfonate, oleic acid, GK2, menthol and borneol; the drug active ingredient can be any one combination of the following ingredients: palonosetron hydrochloride, granisetron, ondansetron, azasetron and tropisetron; and the ingredients of the buffer are sodium citrate buffer solution and phosphate buffer solution. The oral spray provides a formulation which is safer, painless and convenient for patients with advanced tumor, elderly and weak patients, children patients and the patients who suffer from the metal illness and do not obey the oral administration or the injection drug administration.

The invention relates to a dealcoholic preparation, specifically to a dealcoholic preparation which can make drinkers get rid of symptoms of headache and nausea and make them recover in a short period of time. The dealcoholic preparation is characterized by comprising the following substances of: 400-800 mg of lactose, 80-300 mg of starch, 50-150 mg of maltose, 50-100 mg of turmeric powder, 10-20 mg of curcumin, 100-250 mg of inositol, 30-70 mg of citric acid, 10-40 mg of nicotinic acid, 50-150 mg of vitamin C, 4-8 mg of vitamin E, 5-15 mg of vitamin B6, 30-70 mg of flavouring composition and 50-250 mg of a flavouring agent. In comparison with the prior art, the dealcoholic preparation can be taken to make drinkers rapidly get rid of symptoms of headache and nausea and make them recover in a short period of time, and has an effect of protecting liver.

The invention relates to a preparation method of ramosetron derivatives and applications thereof. The invention provides a compound as expressed in the formula (I), a pharmaceutically acceptable salt thereof, an enantiomer or racemic mixture thereof, wherein, R1 is H, C1-C6 alkyl, C1-4 alkyloxys, aryls or substituted C1-C4 alkyl. The invention also provides a preparation method of the compound or the pharmaceutically acceptable salt thereof, the pharmaceutical composition containing the compound and the salt, and applications of the compound. The compound in the invention possesses functions of preventing and treating the digestive tract symptoms of nausea, vomit, etc. caused by anti-malignant tumor treatment, and preventing and treating irritable bowel syndrome. The compound can be used in preparing medicine for preventing and treating the digestive tract symptoms of nausea, vomit, etc. caused by anti-malignant tumor treatment, and irritable bowel syndrome.

The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed/fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

The invention discloses a preparation method of a traditional Chinese medicine ointment for preventing and treating delayed nausea and vomiting caused by chemotherapy. The preparation method comprises the steps that raw materials are smashed; smashed amomum villosum is fetched for extracting amomum villosum volatile oil by a steam distillation method; fresh ginger is juiced to obtain ginger juice; and smashed pinellia rhizoma prepared by ginger, cassia twigs, agastache rugosus, fructus evodiae, inula flower, pericarpium citri reticulatae, ligusticum wallichii, menthol, folia perillae acutae, endothelium corneum gigeriae galli, sea-buckthorn, the amomum villosum volatile oil and the ginger juice are evenly mixed and added with honey to be stirred in a paste shape, and the traditional Chinese medicine ointment is obtained. The preparation method has the advantages that the composition is rigorous, preparation is easy, irritation is avoided, the price is low, operation is simple and convenient, the ointment can be accepted by patients easily, and the ointment has a wide clinical application prospect. The invention further discloses application of the traditional Chinese medicine ointment for treating delayed nausea and vomiting combined with granisetron and dexamethasone. The traditional Chinese medicine ointment can well treat delayed nausea and vomiting and inappetence caused by cis-platinum, also can relieve the side effects, like constipation of patient, caused by the usage of the granisetron and dexamethasone, has good compliance, and reaches the international leading level.

The invention relates to a traditional Chinese medicine composition for treating nausea and vomiting caused by chemotherapy, traditional Chinese medicine decoction-free granules and application and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials: 6-15 parts of ginger processed pinellia, 10-15parts of dried ginger, 6-15 parts of exocarpium citri grandis, 10-15 parts of white poria, 3-12 parts of rice water processed fructus aurantii, 10-15 parts of pogostemon cablin, 2-4 parts of preparedrhizoma coptidis with rhizoma zingiberis recens juice, 3-5 parts of liquor processed scutellaria baicalensis, 15-30 parts of reed rhizome, 5-12 parts of bamboo shavings, 5-9 parts of perilla leaves, 9-15 parts of codonopsis pilosula Nnannf and 2-6 parts of raw licorice roots. The traditional Chinese medicine decoction-free granules are prepared from the above-mentioned single traditional Chinese medicine formula granules by weight. The traditional Chinese medicine composition and the traditional Chinese medicine decoction-free granules are applied to preparation of drugs for treating nausea and vomiting caused by chemotherapy. The traditional Chinese medicine composition has the advantages of replenishing qi, strengthening spleen, invigorating the stomach, calming the adverse-rising energy, eliminating phlegm, regulating body immunity and inhibiting tumor growth; synergizing with chemotherapeutic drugs to achieve enhanced sensitivity, alleviating vomiting symptoms; and regulating digestive tract functions.

The invention provides a summer-heat relieving cola, which can prevent gastrointestinal diseases and summertime colds. The summer-heat relieving cola is prepared according to the following steps: preparing ageratum, perilla leaf, ginger and mung bean with the weight ratio of 8-15:8-15:1-2:3-5, decocting and filtering; adding citric acid and lemon essence in a filter liquor for respectively adjusting a pH value and seasoning taste, depositing and then filtering; taking white granulated sugar and distilled water with the weight ratio of 2:1 to prepare simple syrup; and properly adding the simple syrup into the finally-prepared filter liquor to obtain the summer-heat relieving cola. The invention has delicious taste and fragrant smell, and can prevent and treat headache, dizziness, fever, nausea, stomachache, abdominal distention, diarrhea and fatigue caused by summer colds, gastrointestinal type colds, condition diseases and acute gastroenteritis.

A drug composition for treating vomiting during pregnancy is formed by compositing doxylamine succinate or a composition of doxylamine succinate and pyridoxine hydrochloride as an active ingredient, and pharmaceutically acceptable auxiliary materials. The drug composition can be prepared into an oral preparation, including a tablet, a capsule and the like, by a certain preparation technology. The drug composition is used for treating women who have nausea and vomiting during the pregnancy and poor response to conservative treatment.

The invention discloses a traditional Chinese medicine for treating chronic gastritis and a preparation method thereof. The preparation disclosed by the invention is a composition liquid preparation which is prepared by the following steps: smashing, decocting, ethanol-extracting and mixing pogostemon cablin, folia perillae acutae, rhizoma atractylodis macrocephalae, pericarpium arecae, guergana guermanoff, rhizoma atractylodis, tribulusterrestris, amomum kravanh, immature bitter oranges, rhizoma cyperi, ligusticum wallichii, orange peels, polygonum cuspidatum, rhizoma corydalis, semen coicis, scutellaria baicalensis, sargentgloryvine stems, bletilla, millet and the like. The traditional Chinese medicine is remarkable in effect of treating chronic gastritis, has a remarkable effect of treating symptoms such as flautulence after meal, acid regurgitation, irregular stomachache, epigastric discomfort, ache, dyspepsia, vomiting, hiccup and nausea, and is simple in preparation method, stable in effect and less in side effect.

The orally disintegrated granisetron tablet as antiemetic is prepared with granisetron hydrochloride as main medicine component, hydroxyethyl cellulose and other medicinal supplementary material. After being taken, the antiemetic may be disintegrated fast in orally and swallowed into digestive tract without need water to produce excellent effect of preventing and treating nausean and vomiting caused by chemotherapy, radiotherapy and surgical operation. The present invention has low production cost.

The invention discloses a traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy. The traditional Chinese medicine combination comprises, by weight, 20-25 parts of pinellia rhizoma prepared by ginger, 15-20 parts of cassia twigs, 10-15 parts of agastache rugosus, 10-15 parts of fructus amomi, 8-12 parts of fructus evodiae, 4-10 parts of inula flower, 4-6 parts of pericarpium citri reticulatae, 10-16 parts of ginger juice and 1-3 parts of menthol. The traditional Chinese medicine combination has the advantages of being rigorous in composition, easy to prepare, free of stimulus, low in cost, easy to operate and capable of being accepted by patients easily. The traditional Chinese medicine combination is combined with granisetron and dexamethasone for use, can well treat delayed nausea and vomiting and loss of appetite caused by cis-platinum, also can relieve the side effects, like constipation of patient, caused by the usage of the granisetron and dexamethasone, provides a novel way for delayed nausea and vomiting patients, fills the blank of treating the delayed nausea and vomiting through traditional Chinese medicine at home and abroad, and reaches the international leading level.

The invention discloses a traditional Chinese medicine for assisting smoking cessation. The traditional Chinese medicine is prepared from the following materials in parts by weight: 30-40g of fructusgleditsiae, 18-25 fructus ziziphi jujubae, 30-40g of rhizoma arisaematis, 30-40g of rhizoma anemarrhenae, 25-75g of gypsum, 25-35g of rhizoma pinelliae, 20-35g of radix bupleuri, 20-35g of radix scutellariae, 20-40g of rhizoma coptidis, 20-40g of cortex phellodendri and 20-40g of radix curcumae. Different from other products, the traditional Chinese medicine is practical and has the advantages ofcapabilities of enabling patients with cigarette habit to completely give up smoking in the mentally, enabling the patients to have nausea when smelling the cigarette smell at the beginning of smokingcessation and maintain happy mood, enabling the lung, the liver and the stomach to be free of uncomfortable symptoms during smoking cessation, enabling the lung and the blood vessels to rapidly cleancigarette tar accumulated in the body, enabling the patients to maintain unchanged original body figure after carrying out smoking cessation for one month and preventing the body from gaining weightduring smoking cessation. The traditional Chinese medicine is free of toxic and side effects, low in cost and extremely obvious in effect.

The invention discloses an ointment formula for harmonizing the stomach and stopping vomiting and a preparation method and application thereof. The ointment formula for harmonizing the stomach and stopping vomiting is composed of the following ingredients (by weight): 40-60 parts of chicken's gizzard membrane, 130-170 parts of Chinese yam, 80-120 parts of clean haw, 30-70 parts of perilla stem, 30-70 parts of liquorice tablets, 10-50 parts of steamed dried orange peel, 50-85 parts of bamboo shavings, 30-70 parts of prepared pinellia tuber, 50-85 parts of Radix Ophiopogonis, 80-120 parts of fried Radix Codonopsis, 50-85 parts of dry dendrobium, 100-140 parts of Poria cocos, 130-170 parts of malt, 50-85 parts of bighead atractylodes rhizome, 10-50 parts of banksia rose, 10-50 parts of xylitol and 30-70 parts of ginger. The ointment formula for harmonizing the stomach and stopping vomiting can be combined with platinum-based chemotherapy to remarkably improve side effects after chemotherapy, such as inappetence, nausea and vomit, improve clinical symptoms and physical functions for later period tumor patients after chemotherapy and enhance life quality of the later period tumor patients. Meanwhile, the ointment formula for harmonizing the stomach and stopping vomiting has good safety, has good pharmacoeconomic advantages and is worthy of promotion and application.

The invention discloses a functional beverage suitable for use in diabetic patients for resisting preoperative and postoperative stress response, and belongs to the technical field of functional beverages. The functional beverage is prepared by clarifying a sea buckthorn raw juice to obtain a sea buckthorn clear juice; clarifying a blueberry raw juice to obtain a blueberry clear juice; then compounding the sea buckthorn clear juice, the blueberry clear juice and water, uniformly mixing, adding D-ascorbic acid, then adding sodium citrate to adjust the acidity, adding fructose, xylitol and sucralose after the acidity is adjusted, then adding potassium sorbate, finally adding casein phosphopeptide and other nutrition enhancers, and uniformly mixing. The functional beverage can resist postoperative stress reaction, improve immune function of patients, stimulate insulin sensitivity so as to reduce postoperative insulin resistance, reduce wound infection, reduce postoperative nausea and vomiting, reduce sedation and somnolence, help patients to be discharged early, reduce other complications in perioperative period, and is suitable for rapid rehabilitation of surgical patients.

The invention relates to the technical field of preparation of traditional Chinese medicines and particularly discloses an acupoint-application drug for treating postoperative nausea and vomiting. Theacupoint-application drug comprises the following raw materials: inula flowers, rhizoma pinelliae, fructus evodiae, dried ginger and prepared licorice roots. According to the acupoint-application drug and the use method therefor, among the selected five traditional Chinese medicines, the inula flowers and the fructus evodiae are applied together to enhance the effect of lowering the adverse flowof Qi and preventing vomiting, the dried ginger and the rhizoma pinelliae are pungent in flavor and warm in property to dispel cold, are combined therapy of cooling with warming and are acrid in opening and bitter in down-bearing, the adjuvant licorice roots are used for tonifying the spleen and stomach, and the five traditional Chinese medicines exert the effects of coordinating the function of the stomach and normalizing the middle-warmer and soothing Qi and lowering the adverse flow of Qi; and acupoint application is a special external therapy of traditional Chinese medicine and is mainly based on the theory of channels and collaterals, certain acupoint application drugs are selected under the principle of treatment according to syndrome differentiation, actions are exerted through acupoint stimulation and the drugs, thus, the method has the characteristics of simplicity, convenience, accuracy, low cost and the like, and the problems that the postoperative nausea and vomiting cannotbe excellently prevented and treated by virtue of drugs singly and preventing and treating drugs are more in adverse reactions and cost at present are solved.

The invention relates to a natural medicine composition, a preparation method thereof and application of the medicine composition in medicines used for preventing and treating nausea and vomiting caused by cancer chemotherapy and having a synergistic effect on cancer treatment. The natural medicine composition is composed of a pepper extract and procyanidins, wherein the mass ratio of the pepper extract to procyanidins is 1:(1-9). The natural medicine composition provided by the invention is an innovative natural medicine composition in fit with a polyceptor target proportion, an experiment result shows that the natural medicine composition can be used for preventing and treating nausea and vomiting, comprising acute vomiting and delayed vomiting, caused by cancer chemotherapy and meanwhile, has the effect of assisting tumor inhibition.

The invention discloses a traditional Chinese medicinal beverage with an alcohol effect dispelling function. The traditional Chinese medicinal beverage consists of flos puerariae, fructus amomi rotundus, fructus amomi, costusroot, pericarpium citri reticulatae viride, codonopsis pilosula, atractylodes macrocephala koidz, tuckahoe and medicated leaven, and has the effects of reducing blood pressure, accelerating blood circulation, clearing damp and promoting diuresis, accelerating micturition and stopping sweat, calming nerves and strengthening spleen, promoting digestion, and stopping belly ache, vomiting and diarrhoea. The alcohol effect dispelling speed is high; food is digested quickly; the blood pressure of a drinker can be effectively reduced; nausea after drinking is prevented; moreover, the traditional Chinese medicinal beverage does not have toxic or side effects.

A soup for warming kidney, calming adverse-rising energy and controlling vomiting is prepared from 15 parts of codonopsis pilosula, 10 parts of rhizoma atractylodis macrocephalae, 8 parts of radix liquiritiae, 8 parts of rhizoma pinellinae praeparata, 10 parts of agastache rugosus, 6 parts of fructus amomi, 4 parts of radix aconiti lateralis preparata, 10 parts of malt, 6 parts of endothelium corneum gigeriae galli, 15 parts of almond, 10 parts of flos farfarae, 15 parts of eucommia ulmoides, 15 parts of astragalus membranaceus and 15 parts of salviae miltiorrhizae. The soup can tonify spleen and warm kidney, clear heat and calm adverse-rising energy and control pain and vomiting, and has a remarkable treatment effect on reflux esophagitis, spleen-kidney yang deficiency and nausea and vomiting.

The invention discloses application of a traditional Chinese medicine composition in preparing medicine for treating acute and chronic gastroenteritis. The composition is prepared from, by weight, 20-40 parts of camphor, 200-300 parts of methyl salicylate, 80-110 parts of turpentine oil, 200-300 parts of dementholized peppermint oil, 10-20 parts of oleum ocimi gratissimi, 100-200 parts of camphor oil, 10-30 parts of star anise oil, 10-30 parts of cinnamon oil, 2-4 parts of borneol, 20-35 parts of menthol, 30-50 parts of eucalyptus oil and 40-120 parts of camellia oil extract. The traditional Chinese medicine composition is used for preparing medicine for treating acute and chronic gastroenteritis, from the intrinsic pathogenesis, Chinese herbs are adopted as the components, and no toxic or side effect exists; it is found in clinical research that the medicine has a good relieving effect on abdominal pain, abdominal distension, nausea, vomiting and other symptoms and has a good clinical treatment effect on acute and chronic gastroenteritis, especially, acute gastritis.

The invention provides a liver protection and hangover alleviating composition. The composition is prepared from, by weight, 5-30 parts of synsepalum dulcificum, 5-30 parts of caulis bambusae in taeniam, 5-30 parts of radix puerariae, 5-30 parts of herba houttuyniae, 1-40 parts of fructus crataegi, 1-20 parts of fructus momordicae, 5-30 parts of flos chrysanthemi and 5-30 parts of ampelopsis grossedentata. The raw materials are all medicinal and edible, and the composition has efficiencies of heat clearing, detoxifying, Yin nourishing, saliva secretion promoting, diuresis promoting, digestionpromoting and liver and stomach protecting and is capable of effectively alleviating discomforts including alcohol allergies, dizziness, nausea and vomiting, stomach distension, gastric acid and the like and repairing liver damages caused by chronic alcohol ingestion. The liver protection and hangover alleviating composition is free of toxic and side effects.