100 results about "Have Nausea" patented technology

Provided are methods for the treatment of SCLC patients by administering therapeutic amounts of lurbinectedin by intravenous infusion. Also provided are methods of treating cancer by administering lurbinectedin in combination with other anticancer drugs, in particular topoisomerase inhibitors. The invention further relates to the administration of lurbinectedin in combination with anti-emetic agents for effective control of symptoms related to nausea and vomiting, reduced lurbinectedin dosages to achieve a safer administration and an increase in the number of treatment cycles. Stable lyophilized formulations of lurbinectedin are also provided.

The invention belongs to the technical field of health-care food, and particularly relates to a composition and oral drops with the effects of dispelling the effects of alcohol, protecting the liver and relieving hangover as well as a preparation method and application of the composition and the oral drops. The invention provides a composition taking silybin eutectic crystal, curcumin eutectic crystal, ampelopsis grossedentata extract, pyrroloquinoline quinone disodium salt, reduced glutathione, alpha-ketoglutaric acid, vitamin, hericium erinaceus extract, frankincense extract, licorice extract and the like as main active ingredients, and the composition is subjected to scientific formula screening and functional verification, and has the advantages that the composition has the obvious curative effect, and the curative effect is obvious; the traditional Chinese medicine composition can effectively improve the metabolism of ethanol, protect liver and gastric mucosa, and is helpful for relieving hangover-related symptoms such as fatigue, thirst, sleepiness, headache, dry mouth, stomachache, nausea, hypomnesis, inattention and the like.

The invention discloses an anesthesia reviving room risk assessment system for postoperative nausea and vomiting prediction, relates to the technical field of postoperative nausea and vomiting prediction, and aims to perform multi-modal fusion on clinical features of a patient and brain function signals to realize basic probability calculation of postoperative nausea and vomiting risks, and introduce real-time dynamic physiological parameters as regulatory factors to realize postoperative nausea and vomiting risk prediction. And performing adaptive adjustment on the basic prediction result to generate a comprehensive risk probability value. The system can collect and process data in real time after a patient enters an anesthesia reviving room, and dynamic and personalized risk assessment is achieved. Compared with a traditional scoring method which only depends on static clinical features, the method has the advantages that tiny fluctuation of the postoperative physiological state of the patient can be captured, prediction precision and timeliness can be improved, clear decision support can be provided for nursing staff, and therefore preventive intervention measures are optimized, and the occurrence rate of complications is reduced.

The invention provides the aprepitant and palonosetron hydrochloride compound emulsion for injection, the compound emulsion has better stability, nausea and vomiting can be more conveniently and effectively prevented and treated, and the medication compliance of patients is improved.

The invention relates to the technical field of intelligent nursing, in particular to an intelligent nursing intervention system and method for nausea and vomiting after a pulmonary operation. The analysis of nausea and vomiting performance is established on the basis of continuous and quantifiable indexes, the sensitivity of judging a risk trend is improved, a risk change path is identified through a long-short-term memory neural network, an influence rule of intervention intensity on a nausea and vomiting evolution trend is accurately described, stage prediction of a nursing intervention effect is realized, and the risk prediction accuracy is improved. Structural optimization is performed on an intervention time sequence and nursing task allocation and execution rhythm through a convolutional neural network, an intervention rhythm path is recombined in combination with resource adaptation information, the coverage density of intervention measures for risk periods is enhanced, integrated response of nursing resources in a high-sensitivity interval is promoted, and synchronous optimization of task allocation and time sequence matching is realized.

Nausea and vomiting are unpleasant events caused by a variety of triggering factors. Wherein medicines often cause nausea and vomiting. An anti-tumor chemotherapeutic agent is one of the most emetic drugs, and often causes chemotherapy-induced nausea and vomiting (CINV). The latter seriously impairs the therapeutic effect and the quality of life of the patient. It is of great interest in determining agents capable of preventing and combating drug-induced nausea and vomiting, including CINV. A calcitonin gene-related peptide (CGRP) is a neuropeptide having various effects in a human body. However, neuropeptide effects in the brain are still to be clarified. CGRP receptor antagonists (named as gezepam) have been recently approved for use in the treatment of migraine. The use of gezepams for the direct treatment of nausea and vomiting, including CINV, is described.

Provided are methods for the treatment of SCLC patients by administering therapeutic amounts of lurbinectedin by intravenous infusion. Also provided are methods of treating cancer by administering lurbinectedin in combination with other anticancer drugs, in particular topoisomerase inhibitors. The invention further relates to the administration of lurbinectedin in combination with anti-emetic agents for effective control of symptoms related to nausea and vomiting, reduced lurbinectedin dosages to achieve a safer administration and an increase in the number of treatment cycles. Stable lyophilized formulations of lurbinectedin are also provided.

A Limosilactobacillus fermentum strain capable of alleviating a hangover and the use thereof. The strain is at least one strain of Limosilactobacillus fermentum ibiome020, Limosilactobacillus fermentum ibiome021 and Limosilactobacillus fermentum ibiome022 respectively deposited with deposit numbers of CCTCC NO: M 2024188, CCTCC NO: M 2024222 and CCTCC NO: M 2024189. The Limosilactobacillus fermentum is a natural bacterium derived from the intestine of a healthy human and has high safety; can alleviate chronic / acute alcoholism, alcoholic intestinal damage or alcoholic liver damage; can accelerate the metabolism of ethanol and / or acetaldehyde, and delay the onset of intoxication; can shorten the sobering-up time; can reduce the mortality caused by drinking alcohol; can reduce the liver index; can lower the level of AST and / or ALT in serum; can alleviate discomfort caused by ethanol and / or acetaldehyde, and mitigate symptoms such as dizziness, headache, nausea and vomiting, and hangover after drinking alcohol; can ameliorate oxidative stress caused by alcohol, and increase the level of GSH in the liver; and also has excellent resistance to gastrointestinal fluid and bile salt, and can adapt to the complex environment within the body.

The invention belongs to the technical field of biological medicines and microorganisms, and particularly relates to a parabacteroides couchneri MRD02 and application thereof, the parabacteroides couchneri is Parabacteroides couchneri MRD02, the preservation number is GDMCC No.64793, and the preservation unit is Guangdong Province Microbial Culture Collection Center. The invention further discloses a preparation method of the parabacteroides couchneri MRD02 and application of the parabacteroides couchneri MRD02. The Parabacteroides goldsteinii MRD02 disclosed by the invention can be used for remarkably inhibiting joint swelling and systemic inflammation of rheumatoid arthritis of mice, and the inhibiting effect of the Parabacteroides goldsteinii MRD02 is remarkably superior to that of other parabacteroides strains; meanwhile, due to the fact that the usage amount of the Parabacteroides goldsteinii MRD02 is small, gastrointestinal reactions of nausea, vomiting or diarrhea are not found in the Parabacteroides goldsteinii MRD02, and anaphylactic reactions are also not found in the Parabacteroides goldsteinii MRD02.

The present invention relates to the field of medicine and food technology, and relates to a composition for relieving nausea and vomiting, and specifically to a composition obtained by mixing, heating and beating with ginseng and ginger as main raw materials, and its application in the preparation of a drug for relieving / treating nausea and vomiting. In the composition, the mass ratio of ginseng to ginger is 1:10-1:60, and the mass ratio of the mixed raw materials of ginseng and ginger to water is 1:10-1:40. The composition comprises total ginsenosides and total gingerols, wherein the total ginsenoside content is 15-55%, the total gingerol content is 2.5-9%, and the rare ginsenoside content accounts for more than 60% of the total ginsenoside content of total ginseng. The composition is prepared by the following method: mixing ginseng with fresh ginger, soaking in water, mixing and beating at 60-100°C for 30-75min, that is. The composition of the present invention can significantly relieve nausea and vomiting, and can be used to treat nausea and vomiting caused by various reasons.

The invention relates to the technical field of ginger moxibustion, in particular to a portable temperature-controllable ginger moxibustion device for arresting vomiting of tumor patients, which comprises a shell, a tube is fixedly connected to the inner side wall of the shell, a pore plate is fixedly connected to the bottom of the tube, a temperature sensor is mounted on the inner side wall of the tube, and a cover is in threaded connection to the top of the shell. A cylinder is fixedly connected to the bottom of the cover body, and an electric heating rod is mounted at the bottom of the cylinder; the electric heating rod is used for simulating heating power of moxa in traditional ginger-separated moxibustion, controllable heating power is used for exciting drug efficacy of ginger of ginger slices on the pore plate, the synergistic effect mechanism that ginger penetrates through heating power and drug efficacy enters the acupoint is perfectly rescribed, the device is designed according to the core requirement of descending adverse-rising energy and arresting vomiting of tumor patients, the device can accurately act on related acupoints for arresting vomiting, and the effect is achieved. The symptoms of nausea and vomiting caused by chemoradiotherapy and the like are effectively relieved.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating postoperative digestive tract reaction of malignant tumors, a preparation and application. The traditional Chinese medicine composition comprises the following active ingredient raw materials in parts by weight: 10-20 parts of fried codonopsis pilosula, 10-20 parts of fried bighead atractylodes rhizome, 10-20 parts of poria cocos, 1-10 parts of liquorice, 10-20 parts of fried endothelium corneum gigeriae galli, 15-25 parts of fried malt, 25-35 parts of adina rubella hance root, 25-35 parts of wild grape root, 15-25 parts of Chinese actinidia root and 15-25 parts of coix seed. The traditional Chinese medicine composition and the preparation can effectively treat patients with malignant tumor postoperative digestive tract reaction, effectively improve symptoms of abdominal distension, stomachache, nausea, vomiting, diarrhea, constipation, anorexia, sour regurgitation, oral cavity / throat dryness and the like of the patients, improve the life quality of the patients and have good safety.

The GIP receptor agonists of this disclosure have antiemetic properties and can therefore be used to reduce or inhibit the frequency or severity of episodes of nausea or vomiting in patients in need.

The utility model discloses a tumor patient nausea and vomiting evaluation device, and particularly relates to the technical field of tumor patient nausea and vomiting evaluation, the tumor patient nausea and vomiting evaluation, the tumor patient nausea and vomiting evaluation device comprises a digital scoring ruler and a facial expression scoring ruler, the bottom end of the digital scoring ruler is provided with a cavity adapted to the sliding placement of the facial expression scoring ruler, and the side end of the facial expression scoring ruler is provided with an accommodating groove; and rolling wheels are rotationally mounted in the accommodating grooves and are in rolling fit with the side walls of the cavities. According to the device, the facial expression scoring ruler is arranged in the digital scoring ruler in a sleeving manner, so that the device is convenient for medical staff to carry and also convenient for the medical staff to select an evaluation tool which is most suitable for a patient to use.

The invention discloses a traditional Chinese medicine composition for treating nausea and / or vomiting, which is prepared from the following traditional Chinese medicines in parts by weight: 8-10 parts of radix paeoniae alba, 2-6 parts of rheum officinale, 2-6 parts of lindera aggregata and 2-4 parts of liquorice. The traditional Chinese medicine composition is reasonable in formula and clear in monarch, minister, assistant and guide, has the effects of strengthening the spleen, harmonizing the stomach, calming the adverse-rising energy and arresting vomiting, and is suitable for various symptoms of nausea and / or vomiting. Clinical research proves that the traditional Chinese medicine composition can remarkably improve the cure rate and shorten the cure time, is high in total effective rate and good in safety, and has good clinical significance.

Compositions and methods for the control and treatment of obesity, metabolic disorders, nausea and vomiting using ODN peptides and synthetic derivatives thereof are disclosed.

The present invention relates to an oily composition comprising maropitant and an oily carrier. The invention also relates to the use of such a composition in the treatment and prevention of nausea and vomiting in a non-human mammal, in particular a dog or cat.

The utility model discloses a record board for nausea and vomiting conditions caused by chemotherapy, and relates to the field of medical instruments. The recording board comprises a panel and a marking block, wherein the panel is provided with two condition information areas and two condition recording grooves; the condition information area comprises four condition grading areas; four condition grading areas of one condition information area respectively have nausea grade information, and four condition grading areas of the other condition information area respectively have vomiting grade information; the condition recording grooves and the condition information areas are arranged in a one-to-one correspondence mode, each condition recording groove comprises a lower transverse groove, a communicating vertical groove, four communicating transverse grooves and four recording vertical grooves, the recording vertical grooves and the condition grading areas are arranged in a one-to-one correspondence mode and are close to the condition grading areas, and the communicating vertical grooves are located on the outer sides of the recording vertical grooves; the communicating transverse groove communicates with the upper end of the recording vertical groove and the communicating vertical groove, and the lower transverse groove is located at the lower end of the communicating vertical groove and forms a T-shaped groove together with the communicating vertical groove; and seven marking blocks are placed in each condition recording groove.

This invention relates to an azabicyclo[3.1.0]hexane derivative that can be used as a 3C-like protease inhibitor. This azabicyclo[3.1.0]hexane derivative can be used to treat fever, nausea, vomiting, headache, dyspnea, fatigue, respiratory tract infection, olfactory and gustatory disturbances and their complications, or combinations thereof, caused by novel coronavirus infection.

A use of a compound of formula (I) or a stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt and eutectic thereof or a composition thereof in the preparation of a drug for preventing postoperation nausea and vomiting or chemotherapy-induced nausea and vomiting.

The utility model discloses a gastroscope mouth biting device for the digestive system department, relates to the technical field of medical instruments, and aims to solve the problems that in the process of stretching a gastroscope tube into the mouth, a patient is inevitably subjected to nausea and vomiting due to stimulation, the tongue of the patient also acts due to nausea and vomiting, and then the gastroscope tube is pushed to shake; the tongue pressing device comprises an arc-shaped attaching plate of a U-shaped structure, a tongue pressing part used for limiting the tongue of a patient is detachably installed at the bottom of one side of the arc-shaped attaching plate, and the tongue pressing part comprises a connecting block with the two ends bent inwards to form bent structures; the bent end of the connecting block is provided with a fan-shaped tongue depressor used for abutting against the surface of the tongue of the patient and limiting the tongue. The tongue limiting device has the advantage that the tongue can be limited when a patient is stimulated in the process that the gastroscope tube extends into the tongue limiting device.

The invention relates to the technical field of preparation of liquid medicine for treating corn, in particular to a preparation method of liquid medicine for treating corn. The technical problems that in the prior art, side effects on the human body are large, the nursing difficulty is high, and scars are likely to be formed are solved through the preparation method of the medicine liquid for treating the corn. According to the technical scheme, the preparation method of the liquid medicine for treating the corn comprises the following steps: step 1, sequentially weighing sodium chloride, magnesium chloride, salt, vinegar and brine according to the required weight; 2, fully stirring to completely dissolve sodium chloride, magnesium chloride and salt in the brine, and then adding the rest brine and vinegar; 3, boiling with big fire, and continuing to boil with small fire; all components used for preparing the liquid medicine do not contain hormones, no burden is brought to the skin when the liquid medicine is used for treating the corn, adverse symptoms such as local skin dryness and sensitivity caused by external medicines are avoided, nausea and dizziness are not caused, and the liquid medicine has no damage to the skin of an affected part.

The invention relates to the technical field of biological medicine, in particular to a medicine solution composition, a preparation method thereof, a nasal spray and application. The medicine solution composition comprises a medicine active component, an osmotic pressure regulator, a pH regulator and water. The active pharmaceutical ingredient comprises ondansetron or a pharmaceutically acceptable salt of ondansetron. The medicine solution composition provided by the invention can be quickly absorbed into blood through nasal mucosa, reaches a peak within 5-10 minutes after being administered through nasal spray administration, is expected to take effect quickly, can help a patient to deal with nausea and vomiting caused by cytotoxic chemotherapy and radiotherapy in time and be used for preventing postoperative nausea and vomiting (PONV), and is good in stability.

The present invention relates to a pharmaceutical composition comprising a fixed dose combination of (a) netupitant, or a salt or hydrate thereof, and (b) palonosetron, or a salt or hydrate thereof, in a single pharmaceutical unit. The invention further relates to a method for preparing a pharmaceutical composition in the form of a tablet, the method comprises: (i) wet granulating a dry mixture comprising netupitant or a salt or hydrate thereof, a filler, a binder, a disintegrant, and optionally a surfactant and / or a lubricant, with a solution comprising palonosetron or a salt or hydrate thereof, and optionally a surfactant and / or a binder, to produce granules; (ii) blending the particles with a lubricant, a disintegrant and a glidant, and optionally a filler, and (iii) compacting the lubricated particles to produce a tablet. The invention further relates to the use of said pharmaceutical composition for the treatment and / or prevention of nausea and / or vomiting, preferably for the treatment and / or prevention of acute or delayed nausea and vomiting associated with chemotherapy, such as highly or moderately emetically induced cancer chemotherapy, such as cis-platinum cancer chemotherapy.

This invention provides a method for treating postoperative nausea and vomiting using buccal acupuncture combined with a triple antiemetic regimen. The method employs a combined intervention of buccal acupuncture and a triple antiemetic regimen. The triple regimen consists of a 5-HT3 receptor antagonist, a glucocorticoid, and a dopamine receptor antagonist, administered intravenously in two separate doses. The buccal acupuncture uses CA-2 (upper jiao), CA-3 (middle jiao), and CA-4 (lower jiao) as core acupoints, with auxiliary and reinforcing acupoints added based on the surgical site and high-risk groups. A standardized procedure of pecking stimulation is applied, along with a corresponding postoperative remedial antiemetic medication regimen. This invention organically combines multi-target drug blockade with buccal acupuncture's visceral regulation, synergistically enhancing the antiemetic effect, reducing the incidence of nausea and vomiting, and decreasing the need for remedial medication. The regimen is highly standardized, widely adaptable, and can meet the postoperative nausea and vomiting control needs of various surgeries and high-risk groups. It exhibits good safety, strong repeatability, and high clinical application value.

The present disclosure relates generally to methods of treating, preventing, or reducing nausea, vomiting, or a combination thereof, hyperemesis gravidarum (HG), nausea gravidarum and vomiting (NVP), or sequelae thereof in a human subject in need thereof, the methods comprise administering to the human subject a therapeutically effective amount of an antibody that specifically binds to a human glial cell line derived neurotrophic factor family receptor alpha-like (GFRAL).

A method in which gepants (antagonists of calcitonin gene related peptide (CGRP) receptor) are used for direct treatment of nausea and vomiting including chemotherapy-induced nausea and vomiting (CINV). Among them, drugs frequently prompt nausea and vomiting, such as antitumor chemotherapeutics which often cause CINV which in turn can severely compromise efficacy of therapy, as well as patient quality of life. The method uses antagonists of the CGRP receptor recently approved for migraine treatment to target calcitonin gene related peptide (CGRP), a neuropeptide with pleiotypic effects in the human body to prevent and counteract drug-induced nausea and vomiting including CINV.

Methods and compositions comprising carotenoids for the treatment or prevention of nausea, e.g., chemotherapy-induced nausea and vomiting.

This invention belongs to the field of traditional Chinese medicine technology, and relates to a topical Chinese medicine composition, topical drug, topical patch, acupoint patch, and preparation method and application for treating nausea and vomiting caused by chemotherapy for intracranial tumors. The Chinese medicine composition consists of the following raw materials in parts by weight: 1-2 parts of Ligusticum chuanxiong, 1-2 parts of Gastrodia elata, 2-4 parts of Uncaria rhynchophylla, 1-2 parts of Citrus aurantium, 1-2 parts of Sinapis alba, 1-2 parts of Clematis chinensis, 0.5-1 part of Melia toosendan, 0.5-1 part of Panax ginseng, 1-2 parts of Pinellia ternata, 1-2 parts of Albizia julibrissin bark, 0.5-1 part of Lentinus edodes, and 1-2 parts of Astragalus membranaceus. This Chinese medicine composition has the effects of relieving nausea and vomiting, soothing the liver and strengthening the spleen, detoxifying and eliminating turbidity, calming the liver and extinguishing wind, and calming the mind and soothing the nerves. It not only effectively controls the nausea and vomiting symptoms caused by chemotherapy for intracranial tumors, but also harmonizes the body's Qi and organ functions. The Chinese medicine composition has a simple formula, widely available ingredients, and a simple preparation method; it is for topical application, convenient for clinical use, and has low adverse reactions.