142 results about "Have Nausea" patented technology

There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment.

Extended release ondansetron compositions of the present invention are useful for treating postoperative nausea and vomiting (PONV) and / or postdischarge nausea and vomiting (PDNV).

Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.

This invention is related to a pharmaceutical composition in the patient-friendly orally disintegrating tablet form comprising a weakly basic, selective serotonin 5-HT3 blocking agent for the prevention of nausea and / or vomiting for up to 24 hrs postdosing in cancer patients prior to undergoing moderately emetogenic chemotherapy or partial or whole body radiotherapy or in subjects at moderate to high risk of postoperative or postdischarge nausea and / or vomiting prior to inpatient or outpatient ambulatory surgery. The unit dosage form comprising a multitude of immediate-release drug particles providing dissolution profiles similar to that of reference drug product, and one or more timed, pulsatile-release bead populations, comprising at least one organic acid, which solubilizes said weakly basic selective serotonin 5-HT3 blocking agent prior to releasing it into the hostile intestinal environment, wherein the blocking agent is practically insoluble, is capable of delivering said antiemetic agent in patients in need thereof in a sustained-released fashion to be suitable for a once-daily dosing regimen.

Compositions are provided for the intranasal administration of granisetron or a pharmaceutically acceptable salt thereof. Preferred compositions are in the form of an aqueous solution. Optionally, the compositions comprise chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention of nausea and / or vomiting.

Belonging to the field of medical technologies, the invention specifically relates to a tropisetron hydrochloride compound. The invention also relates to application of an injection containing the tropisetron hydrochloride compound in the crystal form of the invention in preparing medicaments for treating nausea and vomiting.

The invention discloses a new traditional Chinese medicine compound for treating intestinal abscess and a preparation method thereof, wherein the traditional Chinese medicine compound of the invention mainly comprises the following raw material medicines: rhizoma coptidis, fresh rehmannia root, figwort, kudzu vine root, red paeonia, root of herbaceous peony, china root, honeysuckle, dandelion, Chinese violet, Chinese lobelia, satrwort root, rhizoma cyperi, fruit of immature citron, tambac, dalbergia wood, Szchuan lovage rhizome, fried fumitory, fried frankincense, fried myrrh, salvia miltiorrhiza, woodlouse, dragon's blood and the like. The traditional Chinese medicine compound of the invention can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can markedly improve the symptoms of QI stagnation and blood stasis, stomachache or periumbilical pain, fever with chilliness, nausea and vomiting, excessive noxious heat, tense abdomen, tenderness, local lump, spontaneous perspiration due to high fever and the like, and has exact clinical curative effect, remarkable curative effect and rapid effect taking. Because the traditional Chinese medicine compound of the invention is combined by basically adopting medicine-food homologous medicaments specified in National Formulary, the traditional Chinese medicine compound has the advantages of low cost, basically no toxic or side effect and the like.

The invention relates to an oral spray for controlling nausea and vomit of chemotherapy and radiation therapy, the formula of the oral spray is composed of ingredients with the following parts by weight: 5-50 parts of drug absorption enhancer, 2-20 parts of drug active ingredient and 30-90 parts of buffer, the drug absorption enhancer can be any one or the combination of more of the following ingredients: azone, propylene glycol, polysorbate (Tween), ethylene glycol deoxycholic acid sodium salt, brij, sodium decanoate, lauric acid, stearic acid, sodium lauryl sulphate, stearyl alcohol sodium sulfate, dioctyl succinate sodium sulfonate, oleic acid, GK2, menthol and borneol; the drug active ingredient can be any one combination of the following ingredients: palonosetron hydrochloride, granisetron, ondansetron, azasetron and tropisetron; and the ingredients of the buffer are sodium citrate buffer solution and phosphate buffer solution. The oral spray provides a formulation which is safer, painless and convenient for patients with advanced tumor, elderly and weak patients, children patients and the patients who suffer from the metal illness and do not obey the oral administration or the injection drug administration.

The invention relates to a dealcoholic preparation, specifically to a dealcoholic preparation which can make drinkers get rid of symptoms of headache and nausea and make them recover in a short period of time. The dealcoholic preparation is characterized by comprising the following substances of: 400-800 mg of lactose, 80-300 mg of starch, 50-150 mg of maltose, 50-100 mg of turmeric powder, 10-20 mg of curcumin, 100-250 mg of inositol, 30-70 mg of citric acid, 10-40 mg of nicotinic acid, 50-150 mg of vitamin C, 4-8 mg of vitamin E, 5-15 mg of vitamin B6, 30-70 mg of flavouring composition and 50-250 mg of a flavouring agent. In comparison with the prior art, the dealcoholic preparation can be taken to make drinkers rapidly get rid of symptoms of headache and nausea and make them recover in a short period of time, and has an effect of protecting liver.

The invention relates to a preparation method of ramosetron derivatives and applications thereof. The invention provides a compound as expressed in the formula (I), a pharmaceutically acceptable salt thereof, an enantiomer or racemic mixture thereof, wherein, R1 is H, C1-C6 alkyl, C1-4 alkyloxys, aryls or substituted C1-C4 alkyl. The invention also provides a preparation method of the compound or the pharmaceutically acceptable salt thereof, the pharmaceutical composition containing the compound and the salt, and applications of the compound. The compound in the invention possesses functions of preventing and treating the digestive tract symptoms of nausea, vomit, etc. caused by anti-malignant tumor treatment, and preventing and treating irritable bowel syndrome. The compound can be used in preparing medicine for preventing and treating the digestive tract symptoms of nausea, vomit, etc. caused by anti-malignant tumor treatment, and irritable bowel syndrome.

The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed / fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

The present invention relates to an injectable pre-formulation comprising a low viscosity mixture of: a) at least one neutral diacyl lipid and / or at least one tocopherol; b) at least one phospholipid; c) at least one oxygen containing organic solvent; d) at least one 5HT3 antagonist; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. Such compositions may additionally comprise polar solvents and / or further active agents such as opioid agonists and / or antagonists. Methods of treatment, particularly for management of nausea and vomiting such as for post-operative nausea and vomiting and / or therapy induced nausea and vomiting are provided, as well as corresponding uses of the compositions. Administration devices comprising the formulations and kits comprising the devices are also provided.

The invention discloses a complex probiotic preparation for reducing 5-hydroxytryptamine side effects after chemotherapy, the complex probiotic preparation is characterized in that the complex probiotic preparation is prepared by mixing the following probiotics: bifidobacterium breve, lactobacillus acidophilus, lactobacillus casei and Streptococcus thermophilus according to viable number proportion ratio of 1:1-3:1-3:1-3, and the total viable number of the composite probiotic preparation is 20 billion-80 billion; application of the complex probiotic preparation in preparation of drugs for preventing nausea and vomiting after the chemotherapy and application of the complex probiotic preparation in preparation of drugs for improving intestinal mucositis are disclosed.

The present invention relates to a delayed release pharmaceutical composition containing doxylamine succinate and pyridoxine HCl for treatment of nausea and vomiting during pregnancy. More specifically, the present invention concerns a disintegrant-free delayed release pharmaceutical composition for oral administration comprising a core and an enteric coating, wherein said core comprising: a) at least one pharmaceutically active ingredient, and b) at least one pharmaceutically acceptable excipient, wherein said composition provides an in vitro drug release profile of about 80% of active ingredient dissolved within 20 minutes as measured by USP Type II apparatus and also a manufacturing process of said pharmaceutical composition.

The invention discloses a preparation method of a traditional Chinese medicine ointment for preventing and treating delayed nausea and vomiting caused by chemotherapy. The preparation method comprises the steps that raw materials are smashed; smashed amomum villosum is fetched for extracting amomum villosum volatile oil by a steam distillation method; fresh ginger is juiced to obtain ginger juice; and smashed pinellia rhizoma prepared by ginger, cassia twigs, agastache rugosus, fructus evodiae, inula flower, pericarpium citri reticulatae, ligusticum wallichii, menthol, folia perillae acutae, endothelium corneum gigeriae galli, sea-buckthorn, the amomum villosum volatile oil and the ginger juice are evenly mixed and added with honey to be stirred in a paste shape, and the traditional Chinese medicine ointment is obtained. The preparation method has the advantages that the composition is rigorous, preparation is easy, irritation is avoided, the price is low, operation is simple and convenient, the ointment can be accepted by patients easily, and the ointment has a wide clinical application prospect. The invention further discloses application of the traditional Chinese medicine ointment for treating delayed nausea and vomiting combined with granisetron and dexamethasone. The traditional Chinese medicine ointment can well treat delayed nausea and vomiting and inappetence caused by cis-platinum, also can relieve the side effects, like constipation of patient, caused by the usage of the granisetron and dexamethasone, has good compliance, and reaches the international leading level.

The invention relates to a traditional Chinese medicine composition for treating nausea and vomiting caused by chemotherapy, traditional Chinese medicine decoction-free granules and application and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials: 6-15 parts of ginger processed pinellia, 10-15parts of dried ginger, 6-15 parts of exocarpium citri grandis, 10-15 parts of white poria, 3-12 parts of rice water processed fructus aurantii, 10-15 parts of pogostemon cablin, 2-4 parts of preparedrhizoma coptidis with rhizoma zingiberis recens juice, 3-5 parts of liquor processed scutellaria baicalensis, 15-30 parts of reed rhizome, 5-12 parts of bamboo shavings, 5-9 parts of perilla leaves, 9-15 parts of codonopsis pilosula Nnannf and 2-6 parts of raw licorice roots. The traditional Chinese medicine decoction-free granules are prepared from the above-mentioned single traditional Chinese medicine formula granules by weight. The traditional Chinese medicine composition and the traditional Chinese medicine decoction-free granules are applied to preparation of drugs for treating nausea and vomiting caused by chemotherapy. The traditional Chinese medicine composition has the advantages of replenishing qi, strengthening spleen, invigorating the stomach, calming the adverse-rising energy, eliminating phlegm, regulating body immunity and inhibiting tumor growth; synergizing with chemotherapeutic drugs to achieve enhanced sensitivity, alleviating vomiting symptoms; and regulating digestive tract functions.

The invention belongs to the technical field of pharmaceutical preparation and relates to a pharmaceutical composition containing sodium ozagrel and a preparation method thereof. The pharmaceutical composition comprises, by weight, ozagrel: sodium hydroxide: mannitol: dextran: arabinose=(38-40):( 6-8):( 10-12): (10-12):(20-22). The pharmaceutical composition in the ozagrel prescription added with the appropriate amount of arabinose can greatly reduce the vascular irritation, and has a significant effect on relieving nausea, vomiting, diarrhea, loss of appetite, and fullness. The preparation method of the invention has the advantages of improving the stability of the drug after improving the process.

The invention provides an alcohol effect dispelling yoghourt and a making method thereof. The alcohol effect dispelling yoghourt comprises, by weight, 45-55 parts of fresh milk, 10-15 parts of Hovenia acerba Lindl., 14-22 parts of Radix Puerariae powder, 10-15 parts of honey and 3-5 parts of rock sugar. The making method comprises the following steps: crushing Hovenia acerba Lindl.; decocting Hovenia acerba Lindl. powder and the Radix Puerariae powder, and concentrating the obtained decoction; mixing the obtained concentrate with the rock sugar, honey and fresh milk, and sterilizing the obtained mixture; and fermenting the sterilized mixture with lactic acid bacteria. The alcohol effect dispelling yoghourt produced through the method, used to substitute a medicine to realize alcohol effect dispelling, has the advantages of high nutrition values, protection of the gastric mucosa from being damaged by alcohol, enhancement of the detoxifying effect of the liver, improvement of the interference of the alcohol to human body metabolism, and effective prevention and control of headache, nausea and hangover symptoms caused by drunkenness.

The invention provides a summer-heat relieving cola, which can prevent gastrointestinal diseases and summertime colds. The summer-heat relieving cola is prepared according to the following steps: preparing ageratum, perilla leaf, ginger and mung bean with the weight ratio of 8-15:8-15:1-2:3-5, decocting and filtering; adding citric acid and lemon essence in a filter liquor for respectively adjusting a pH value and seasoning taste, depositing and then filtering; taking white granulated sugar and distilled water with the weight ratio of 2:1 to prepare simple syrup; and properly adding the simple syrup into the finally-prepared filter liquor to obtain the summer-heat relieving cola. The invention has delicious taste and fragrant smell, and can prevent and treat headache, dizziness, fever, nausea, stomachache, abdominal distention, diarrhea and fatigue caused by summer colds, gastrointestinal type colds, condition diseases and acute gastroenteritis.

A drug composition for treating vomiting during pregnancy is formed by compositing doxylamine succinate or a composition of doxylamine succinate and pyridoxine hydrochloride as an active ingredient, and pharmaceutically acceptable auxiliary materials. The drug composition can be prepared into an oral preparation, including a tablet, a capsule and the like, by a certain preparation technology. The drug composition is used for treating women who have nausea and vomiting during the pregnancy and poor response to conservative treatment.

The invention discloses a traditional Chinese medicine for treating chronic gastritis and a preparation method thereof. The preparation disclosed by the invention is a composition liquid preparation which is prepared by the following steps: smashing, decocting, ethanol-extracting and mixing pogostemon cablin, folia perillae acutae, rhizoma atractylodis macrocephalae, pericarpium arecae, guergana guermanoff, rhizoma atractylodis, tribulusterrestris, amomum kravanh, immature bitter oranges, rhizoma cyperi, ligusticum wallichii, orange peels, polygonum cuspidatum, rhizoma corydalis, semen coicis, scutellaria baicalensis, sargentgloryvine stems, bletilla, millet and the like. The traditional Chinese medicine is remarkable in effect of treating chronic gastritis, has a remarkable effect of treating symptoms such as flautulence after meal, acid regurgitation, irregular stomachache, epigastric discomfort, ache, dyspepsia, vomiting, hiccup and nausea, and is simple in preparation method, stable in effect and less in side effect.

The orally disintegrated granisetron tablet as antiemetic is prepared with granisetron hydrochloride as main medicine component, hydroxyethyl cellulose and other medicinal supplementary material. After being taken, the antiemetic may be disintegrated fast in orally and swallowed into digestive tract without need water to produce excellent effect of preventing and treating nausean and vomiting caused by chemotherapy, radiotherapy and surgical operation. The present invention has low production cost.

The invention discloses a traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy. The traditional Chinese medicine combination comprises, by weight, 20-25 parts of pinellia rhizoma prepared by ginger, 15-20 parts of cassia twigs, 10-15 parts of agastache rugosus, 10-15 parts of fructus amomi, 8-12 parts of fructus evodiae, 4-10 parts of inula flower, 4-6 parts of pericarpium citri reticulatae, 10-16 parts of ginger juice and 1-3 parts of menthol. The traditional Chinese medicine combination has the advantages of being rigorous in composition, easy to prepare, free of stimulus, low in cost, easy to operate and capable of being accepted by patients easily. The traditional Chinese medicine combination is combined with granisetron and dexamethasone for use, can well treat delayed nausea and vomiting and loss of appetite caused by cis-platinum, also can relieve the side effects, like constipation of patient, caused by the usage of the granisetron and dexamethasone, provides a novel way for delayed nausea and vomiting patients, fills the blank of treating the delayed nausea and vomiting through traditional Chinese medicine at home and abroad, and reaches the international leading level.

The invention discloses a traditional Chinese medicine for assisting smoking cessation. The traditional Chinese medicine is prepared from the following materials in parts by weight: 30-40g of fructusgleditsiae, 18-25 fructus ziziphi jujubae, 30-40g of rhizoma arisaematis, 30-40g of rhizoma anemarrhenae, 25-75g of gypsum, 25-35g of rhizoma pinelliae, 20-35g of radix bupleuri, 20-35g of radix scutellariae, 20-40g of rhizoma coptidis, 20-40g of cortex phellodendri and 20-40g of radix curcumae. Different from other products, the traditional Chinese medicine is practical and has the advantages ofcapabilities of enabling patients with cigarette habit to completely give up smoking in the mentally, enabling the patients to have nausea when smelling the cigarette smell at the beginning of smokingcessation and maintain happy mood, enabling the lung, the liver and the stomach to be free of uncomfortable symptoms during smoking cessation, enabling the lung and the blood vessels to rapidly cleancigarette tar accumulated in the body, enabling the patients to maintain unchanged original body figure after carrying out smoking cessation for one month and preventing the body from gaining weightduring smoking cessation. The traditional Chinese medicine is free of toxic and side effects, low in cost and extremely obvious in effect.

The invention discloses a rice beverage for invigorating spleen and nourishing stomach. The rice beverage comprises the following raw materials in parts by weight: 2-5 parts of ginseng, 8-20 parts ofporia cocos, 5-10 parts of Chinese yam, 5-10 parts of lotus seed, 1-5 parts of fructus amomi, 9-20 parts of white hyacinth bean, 9-20 parts of coix seed, 2-5 parts of orange peel, 2-5 parts of platycodon grandiflorum flower, and 2-5 parts of licorice roots, and further comprises 80-150 parts of rice, 20-30 parts of wheat, 1-4 parts of a grain stabilizer, 0-10 parts of a sweetener and 0-10 parts ofa flavoring substance. The rice beverage has a curative effect in treating spleen and stomach weakness, is safe to use, and has a positive and significant therapeutic effect on patients with spleen and stomach weakness symptoms, such as abdominal pain, abdominal distending pain, anepithymia, anorexia, thin sloppy stool, nausea and vomiting, tiredness, laziness to speak and the like, caused by chronic gastritis, gastroduodenal ulcer, gastroptosis, chronic diarrhea, functional dyspepsia, ulcerative colitis and the like.

The invention discloses an ointment formula for harmonizing the stomach and stopping vomiting and a preparation method and application thereof. The ointment formula for harmonizing the stomach and stopping vomiting is composed of the following ingredients (by weight): 40-60 parts of chicken's gizzard membrane, 130-170 parts of Chinese yam, 80-120 parts of clean haw, 30-70 parts of perilla stem, 30-70 parts of liquorice tablets, 10-50 parts of steamed dried orange peel, 50-85 parts of bamboo shavings, 30-70 parts of prepared pinellia tuber, 50-85 parts of Radix Ophiopogonis, 80-120 parts of fried Radix Codonopsis, 50-85 parts of dry dendrobium, 100-140 parts of Poria cocos, 130-170 parts of malt, 50-85 parts of bighead atractylodes rhizome, 10-50 parts of banksia rose, 10-50 parts of xylitol and 30-70 parts of ginger. The ointment formula for harmonizing the stomach and stopping vomiting can be combined with platinum-based chemotherapy to remarkably improve side effects after chemotherapy, such as inappetence, nausea and vomit, improve clinical symptoms and physical functions for later period tumor patients after chemotherapy and enhance life quality of the later period tumor patients. Meanwhile, the ointment formula for harmonizing the stomach and stopping vomiting has good safety, has good pharmacoeconomic advantages and is worthy of promotion and application.

The invention discloses a Mythic Fungus polysaccharide composition for alcohol effect dispelling, and a preparation method thereof. The preparation method of the composition comprises the following steps: mixing 30-35wt% of Mythic Fungus with 10-18wt% of pueraria flower, 20-30wt% of Poria cocos, 8-12wt% of malt and 12-18wt% of dried orange peel, immersing the above raw materials in cold water for 30min, decocting at a temperature of below 100DEG C for 40-60min, taking the obtained decoction 1, carrying out secondary decoction at a temperature of below 100DEG C for 30-50min to obtain a decoction 2, mixing the decoction 1 with the decoction 2, and concentrating the above obtained decoction mixture to obtain the Mythic Fungus polysaccharide composition for alcohol effect dispelling. The composition is reasonable, solves the problems of headaches, vomiting and normal work influence after alcohol drinking, can rapidly dispel the alcohol effect, and does not cause nausea, vomiting or headaches after the composition is taken after drinking.

The invention discloses a functional beverage suitable for use in diabetic patients for resisting preoperative and postoperative stress response, and belongs to the technical field of functional beverages. The functional beverage is prepared by clarifying a sea buckthorn raw juice to obtain a sea buckthorn clear juice; clarifying a blueberry raw juice to obtain a blueberry clear juice; then compounding the sea buckthorn clear juice, the blueberry clear juice and water, uniformly mixing, adding D-ascorbic acid, then adding sodium citrate to adjust the acidity, adding fructose, xylitol and sucralose after the acidity is adjusted, then adding potassium sorbate, finally adding casein phosphopeptide and other nutrition enhancers, and uniformly mixing. The functional beverage can resist postoperative stress reaction, improve immune function of patients, stimulate insulin sensitivity so as to reduce postoperative insulin resistance, reduce wound infection, reduce postoperative nausea and vomiting, reduce sedation and somnolence, help patients to be discharged early, reduce other complications in perioperative period, and is suitable for rapid rehabilitation of surgical patients.