7 results about "Amisulpride" patented technology

Amisulpride can be used to treat (especially prevent) postoperative vomiting in patients undergoing surgery, where postoperative vomiting could be potentially dangerous.

The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to antagonize serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to treat one or more conditions responsive to modulation of serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to treat one or more disorders associated with abnormal levels of serotonin in the brain.

The invention relates to the technical field of detection, and discloses an amisulpride oral solution detection method, which comprises: S1, sample pretreatment: sequentially carrying out activation, sample loading, elution and elution operation on an oral solution through a solid phase extraction column, and collecting the eluate as a purification liquid; s2, chromatography and mass spectrometry detection: injecting the purified liquid obtained in S1 into an ultra-high performance liquid chromatography and triple quadrupole mass spectrometry combined system; s3, preparing a microorganism test solution, namely mixing the oral solution and the neutralizer solution according to a volume ratio; s4, microbial limit inspection; and S5, preservative detection. The same test solution is synchronously used for microorganism and chemical detection, two key analyses are completed through one-time preparation, compared with a mode that two samples need to be treated separately in a traditional method, the problem of system error accumulation caused by operation redundancy is thoroughly solved, and the scheme remarkably improves the detection efficiency on the premise of ensuring the data accuracy.

Amisulpride can be used to treat postoperative nausea and / or vomiting in patients who have been given prophylactic medication for postoperative nausea and / or vomiting, and in which the dose of amisulpride is 7.5 to 15 mg.

The amisulpride derivatives and R enantiomers of amisulpride disclosed herein, or pharmaceutical compositions thereof, can be used to antagonize serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject, alone or in combination with other CNS active agents. The amisulpride derivatives and R enantiomers of amisulpride or pharmaceutical compositions thereof disclosed herein can be used, alone or in combination with other CNS active agents, for the treatment of one or more conditions responsive to modulation of serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and R enantiomers of amisulpride or pharmaceutical compositions thereof disclosed herein can be used, alone or in combination with other CNS active agents, for the treatment of one or more disorders associated with abnormal serotonin levels in the brain.

The invention relates to the technical field of compound synthesis, and particularly discloses a preparation method of an amisulpride impurity. The preparation method of the amisulpride impurity comprises the following steps: carrying out oxidation reaction on 4-amino-5-(ethylthio)-2-methoxybenzoic acid methyl ester and an oxidizing agent to obtain an intermediate 1; carrying out hydrolysis reaction on the intermediate 1 to obtain an intermediate 2; the intermediate 2 and N-ethyl-2-aminomethylpyrrolidine are subjected to a condensation reaction, and the amisulpride impurity is obtained. According to the preparation method provided by the invention, hydrolysis is taken as an optimization link of a key intermediate, so that the defect of direct condensation in the prior art is effectively overcome, double improvement of the purity and the yield of the amisulpride impurity is realized, and a new thought is provided for preparation of the amisulpride impurity.

Amisulpride is useful in the treatment of postoperative nausea and / or vomiting in a patient, wherein the patient has already been administered a prophylaxis drug for postoperative nausea and / or vomiting, and wherein the dose of amisulpride is 7.5 to 15 mg.