11 results about "Amisulpride" patented technology

Amisulpride can be used to treat (especially prevent) postoperative vomiting in patients undergoing surgery, where postoperative vomiting could be potentially dangerous.

The invention belongs to the technical field of medicine detection, and particularly relates to a method for detecting an impurity A in an amisulpride oral liquid and application of the method. The detection method comprises the following steps: S1, extracting an oral liquid sample containing amisulpride and a potential impurity A thereof; s2, mixing the diluted oral liquid sample with a buffering agent solution and a deriving agent solution, and carrying out a heating derivation reaction to obtain a derivative mixed solution; and S3, diluting the derivative mixed solution, and injecting the diluted derivative mixed solution into high performance liquid chromatography for quantitative analysis. Compared with an existing pharmacopoeia recommendation method, the detection method provided by the invention can more accurately and quantitatively analyze the impurity A in the amisulpride oral liquid, and can be applied to use scenes requiring higher detection precision, such as research on a generation mechanism of the impurity A in a drug synthesis path and the like.

The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to antagonize serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to treat one or more conditions responsive to modulation of serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to treat one or more disorders associated with abnormal levels of serotonin in the brain.

The invention relates to the technical field of detection, and discloses an amisulpride oral solution detection method, which comprises: S1, sample pretreatment: sequentially carrying out activation, sample loading, elution and elution operation on an oral solution through a solid phase extraction column, and collecting the eluate as a purification liquid; s2, chromatography and mass spectrometry detection: injecting the purified liquid obtained in S1 into an ultra-high performance liquid chromatography and triple quadrupole mass spectrometry combined system; s3, preparing a microorganism test solution, namely mixing the oral solution and the neutralizer solution according to a volume ratio; s4, microbial limit inspection; and S5, preservative detection. The same test solution is synchronously used for microorganism and chemical detection, two key analyses are completed through one-time preparation, compared with a mode that two samples need to be treated separately in a traditional method, the problem of system error accumulation caused by operation redundancy is thoroughly solved, and the scheme remarkably improves the detection efficiency on the premise of ensuring the data accuracy.

Amisulpride can be used to treat postoperative nausea and / or vomiting in patients who have been given prophylactic medication for postoperative nausea and / or vomiting, and in which the dose of amisulpride is 7.5 to 15 mg.

Amisulpride is useful in the treatment of postoperative nausea and / or vomiting in a patient, wherein the patient has already been administered a prophylaxis drug for postoperative nausea and / or vomiting, and wherein the dose of amisulpride is 7.5 to 15 mg.

Amisulpride is used in the therapy of nausea, vomiting or retches. The therapy may utilize a novel injectable formulation, in unit dosage form, comprising less than 50 mg amisulpride.

The invention belongs to the field of drug detection, and particularly discloses a pretreatment method and a detection method for detecting drugs in plasma. The pretreatment method comprises the following steps: mixing a plasma sample containing metformin, aripiprazole or amisulpride micromolecule drugs after protein removal with carboxylated TiO2 (at) MWCNTs, and carrying out solid-phase dispersion extraction to obtain a supernatant which is used as a subsequent LC-MS / MS injection sample for detection. The carboxylation modified TiO2 (at) MWCNTs are used as an extraction / adsorption material for solid-phase dispersion extraction, so that the interference of matrixes such as phospholipid and the like is greatly reduced, the influence of an ion inhibition phenomenon and background noise on the quantification of small molecule drugs in the subsequent detection and analysis process is reduced, the sensitivity in LC-MS / MS detection is improved, and the linear detection range is expanded; in addition, the method is simple, convenient, rapid and low in cost.

The amisulpride derivatives and R enantiomers of amisulpride disclosed herein, or pharmaceutical compositions thereof, can be used to antagonize serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject, alone or in combination with other CNS active agents. The amisulpride derivatives and R enantiomers of amisulpride or pharmaceutical compositions thereof disclosed herein can be used, alone or in combination with other CNS active agents, for the treatment of one or more conditions responsive to modulation of serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and R enantiomers of amisulpride or pharmaceutical compositions thereof disclosed herein can be used, alone or in combination with other CNS active agents, for the treatment of one or more disorders associated with abnormal serotonin levels in the brain.

The invention relates to the technical field of compound synthesis, and particularly discloses a preparation method of an amisulpride impurity. The preparation method of the amisulpride impurity comprises the following steps: carrying out oxidation reaction on 4-amino-5-(ethylthio)-2-methoxybenzoic acid methyl ester and an oxidizing agent to obtain an intermediate 1; carrying out hydrolysis reaction on the intermediate 1 to obtain an intermediate 2; the intermediate 2 and N-ethyl-2-aminomethylpyrrolidine are subjected to a condensation reaction, and the amisulpride impurity is obtained. According to the preparation method provided by the invention, hydrolysis is taken as an optimization link of a key intermediate, so that the defect of direct condensation in the prior art is effectively overcome, double improvement of the purity and the yield of the amisulpride impurity is realized, and a new thought is provided for preparation of the amisulpride impurity.

Amisulpride is useful in the treatment of postoperative nausea and / or vomiting in a patient, wherein the patient has already been administered a prophylaxis drug for postoperative nausea and / or vomiting, and wherein the dose of amisulpride is 7.5 to 15 mg.