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6 results about "Amisulpride" patented technology
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Amisulpride, sold under the brand name Solian among others, is an antipsychotic medication used to treat schizophrenia. It is also used to treat dysthymia. It is usually classed with the atypical antipsychotics. Chemically it is a benzamide and like other benzamide antipsychotics, such as sulpiride, it is associated with a high risk of elevating blood levels of the lactation hormone, prolactin (thereby potentially causing the absence of the menstrual cycle, breast enlargement, even in males, breast milk secretion not related to breastfeeding, impaired fertility, impotence, breast pain, etc.), and a low risk, relative to the typical antipsychotics, of causing movement disorders. It has also been found to be modestly more effective in treating schizophrenia than the typical antipsychotics.
Treatment of postoperative emesis with amisulpride
Amisulpride can be used to treat (especially prevent) postoperative vomiting in patients undergoing surgery, where postoperative vomiting could be potentially dangerous.
Owner:LXO IRELAND DESIGNATED EVENT CO
Psychotropic agents and uses thereof
ActiveCN110944630BNervous disorderHeterocyclic compound active ingredientsPsychotropic AgentSerotonin
The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to antagonize serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to treat one or more conditions responsive to modulation of serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and the R enantiomer of amisulpride, or pharmaceutical compositions thereof, disclosed herein can be used alone or in combination with other CNS active agents to treat one or more disorders associated with abnormal levels of serotonin in the brain.
Owner:LB PHARMACEUTICALS INC
Rescue treatment of postoperative nausea and vomiting
Amisulpride can be used to treat postoperative nausea and / or vomiting in patients who have been given prophylactic medication for postoperative nausea and / or vomiting, and in which the dose of amisulpride is 7.5 to 15 mg.
Owner:LXO IRELAND DESIGNATED EVENT CO
Psychogenic agents and uses thereof
The amisulpride derivatives and R enantiomers of amisulpride disclosed herein, or pharmaceutical compositions thereof, can be used to antagonize serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject, alone or in combination with other CNS active agents. The amisulpride derivatives and R enantiomers of amisulpride or pharmaceutical compositions thereof disclosed herein can be used, alone or in combination with other CNS active agents, for the treatment of one or more conditions responsive to modulation of serotonin (e.g., 5-HT2a, 5-HT7) receptors in a subject. The amisulpride derivatives and R enantiomers of amisulpride or pharmaceutical compositions thereof disclosed herein can be used, alone or in combination with other CNS active agents, for the treatment of one or more disorders associated with abnormal serotonin levels in the brain.
Owner:LB PHARMACEUTICALS INC
Preparation method of amisulpride impurity
The invention relates to the technical field of compound synthesis, and particularly discloses a preparation method of an amisulpride impurity. The preparation method of the amisulpride impurity comprises the following steps: carrying out oxidation reaction on 4-amino-5-(ethylthio)-2-methoxybenzoic acid methyl ester and an oxidizing agent to obtain an intermediate 1; carrying out hydrolysis reaction on the intermediate 1 to obtain an intermediate 2; the intermediate 2 and N-ethyl-2-aminomethylpyrrolidine are subjected to a condensation reaction, and the amisulpride impurity is obtained. According to the preparation method provided by the invention, hydrolysis is taken as an optimization link of a key intermediate, so that the defect of direct condensation in the prior art is effectively overcome, double improvement of the purity and the yield of the amisulpride impurity is realized, and a new thought is provided for preparation of the amisulpride impurity.
Owner:HEBEI LONGHAI PHARMA
Rescue treatment of post operative nausea and vomiting
PendingUS20250367211A1Digestive systemPharmaceutical delivery mechanismHave NauseaPharmaceutical drug
Amisulpride is useful in the treatment of postoperative nausea and / or vomiting in a patient, wherein the patient has already been administered a prophylaxis drug for postoperative nausea and / or vomiting, and wherein the dose of amisulpride is 7.5 to 15 mg.
Owner:LXO IRELAND DESIGNATED ACTIVITY CO +1