50 results about "Chloroformate" patented technology

The invention discloses a method for synthesizing alkyl carbonate through gas-phase carbonylation. Comprising a dechlorination method and a chlorine circulation process in the process of preparing alkyl carbonate through a gas-phase oxidative carbonylation reaction of carbon monoxide and alkyl nitrite. The content of water and alkyl alcohol in circulating gas is controlled through solvent absorption, alkyl chloride is synthesized with a chlorine supplementing agent HCl and alkyl chloroformate under the action of a dechlorinating agent, and the alkyl chloride is separated from a product through gas-liquid separation. When alkyl carbonate is produced by adopting the dechlorination method and the dechlorination process, the problem of equipment corrosion caused by chlorides can be avoided, the dechlorination process is a low-cost and environment-friendly chlorine circulation process, and stable operation of an industrial device is realized.

The invention provides a synthesis process of tert-amyl peroxy-2-ethylhexyl carbonate, and relates to the technical field of organic synthesis.The synthesis process comprises the following steps that S1, caustic soda liquid and water are pumped into a reaction kettle; s2, tert-amyl hydroperoxide is added into the reaction kettle for a salt forming reaction; s3, after the salt forming reaction is finished, adding a catalyst, dropwise adding isooctyl chloroformate, and carrying out condensation reaction to obtain a crude product of tert-amyl 2-ethylhexyl peroxide; and S4, carrying out alkali washing and water washing on the peroxide 2-ethylhexyl tert-amyl carbonate crude product to obtain a finished product. The catalyst is a tree-shaped structure catalyst of a silica gel carrier, and has the advantages of high conversion rate and high yield.

The application belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of diisopropyl peroxydicarbonate and application of the diisopropyl peroxydicarbonate. The preparation method comprises the following steps: firstly, isopropyl chloroformate and an ester-soluble organic solution are added into a three-necked flask, stirring is started, hydrogen peroxide solution is added, when the temperature of the mixture in the flask is stabilized at-5 DEG C, sodium hydroxide solution is slowly added into the three-necked flask, and the time and temperature in the reaction process are controlled; finally, the organic phase is separated, washed with water, dried with anhydrous sodium sulfate, and obtained. The preparation method is safe and controllable, the yield of the diisopropyl peroxydicarbonate is high, the stability is good, the diisopropyl peroxydicarbonate can be directly used for the preparation of polyvinylidene fluoride, a chain transfer agent is not needed, polymerization can be carried out under low-temperature conditions, the molecular chain regularity of the polyvinylidene fluoride is improved, abnormal structures are few, the crystallinity is high, and the comprehensive performance is good.

The invention discloses a positive pole piece and a preparation method thereof, a diaphragm-free battery and a battery. The positive pole piece comprises a positive pole current collector and a positive pole active material layer arranged on at least one side of the positive pole current collector, the positive pole active material layer comprises a polymer, and the polymer is formed by polymerizing at least one of small molecules of the following raw material components: vinylethylene carbonate, vinylene carbonate, 2, 3, 4-trimethyl-1, 3-pentanedione, 2, 3, 4-trimethyl-1, 3-pentanedione and 2, 3, 4-trimethyl-1, 3-pentanedione. The adhesive is prepared from 2, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The adhesive is prepared from the following raw materials: 1, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The positive pole piece provided by the invention comprises the polymer, so that the interface impedance can be reduced, and the rate capability of the battery can be improved.

This invention belongs to the field of chloroformate synthesis technology, and particularly relates to a continuous preparation method of chloroformates, comprising the following steps: 1) feeding the reactant raw material alcohol and phosgene together into a synthesis tower via an absorption tower for reaction, generating crude chloroformate and byproduct hydrogen chloride; 2) sending the crude chloroformate formed in step 1) to a degassing tower, returning the phosgene removed from the degassing tower to the synthesis tower for further reaction, and then distilling the chloroformate after phosgene removal into a purification system to obtain the target product chloroformate; 3) sending the byproduct hydrogen chloride formed in step 1) into an absorption tower for washing with the raw material alcohol and then into the tail gas system. The beneficial effects of this invention are: it realizes continuous production of chloroformate products through synthesis and deacidification, improves the synthesis reaction rate, and shortens the deacidification time; simultaneously, through the recovery and recycling of phosgene, it reduces raw material consumption and forms a clean, inherently safe, automated production process.

Biodegradable, controlled release microcapsules whose microcapsule walls comprise the reaction product of fractured plant proteins with isocyanates and / or bis- or poly-chloroformates.

The invention discloses anti-mildew plastic for a packaging container and a preparation method of the anti-mildew plastic, and relates to the technical field of plastic. The plastic is prepared from the modified biochar and the modified polyethylene; wherein 3, 5-diformylphenylboronic acid, 5-nitro-2-(oxiranyl methoxy) acetophenone, ethynyl magnesium bromide, isobutyldichlorosilane, hydroxylamine hydrochloride, ammonium salt and 3-butenyl chloroformate are used for synthesizing an anti-aging substance, then the anti-aging substance and polyethylene are subjected to cross-linking modification, an ultraviolet absorption group, a silicon-carbon bond and a boron-carbon bond are introduced into a polyethylene side chain, and the anti-aging substance is prepared. While the photo-thermal aging of the plastic is prevented, the barrier property of the plastic is improved; the biochar is modified by aminopropyl methyl dimethoxysilane, N, N-diethyl-p-aminobenzaldehyde, 11-chlorodecanoic acid and chitosan, antibacterial groups are generated on the surface of the biochar, and the biochar and modified polyethylene can be stacked in order, so that movement of water vapor and oxygen is prevented, and the anti-mildew effect of the plastic is improved.

This invention belongs to the field of peroxide preparation technology, specifically relating to a heat exchange device and method for preparing peroxides. The heat exchange device includes heat exchange tubes disposed within a reaction vessel, with several heat exchangers mounted on the heat exchange tubes. Each heat exchanger includes several external fins spaced apart on a fixed plate. The fixed plate has grooves that mate with the heat exchange tubes, and the heat exchange tubes are disposed within these grooves. The peroxide preparation method involves stirring a desensitizer, a catalyst, and an oxidant together, followed by the addition of an alkyl acyl chloride or an alkyl chloroformate to continue the reaction. After the reaction is complete, a crude product is obtained. The crude product is then washed and separated to obtain the peroxide. This invention utilizes the high-efficiency heat transfer performance of the heat exchanger, thereby enabling stable preparation of peroxide products, reducing the reaction time, and improving the conversion efficiency from initial raw materials to peroxide products.

The present application relates to a kind of aryl carboxylate compounds and its preparation method, preparation method includes the following steps: S1, under inert atmosphere, chloroformate or its derivative, aryl iodine, ligand, reducing agent, additive and catalyst are dissolved in solvent, obtain the reaction body solution;S2, the reaction body solution obtained in S1 step is stirred, obtain the aryl carboxylate compound of structural general formula as shown in III, wherein, R 1 Group is selected from H, 4-trifluoromethyl, 4-methoxy, 4-methyl formate in any one of methyl group, R 2 It is selected from 4-trifluoromethyl, 4-acetyl, 4-methyl formate in any one of methyl group.Compared with prior art, the present application uses chloroformate or its derivative, aryl iodine as substrate, aryl carboxylate compound is prepared, reaction condition is mild and substrate is widely adaptable, yield is as high as 80%.And raw material cost is low and easy to obtain, preparation condition is simple and also easy to realize.

This invention belongs to the field of nanomedicine technology, specifically relating to a pH / hypoxia dual-responsive polymer, nanomicelles, their preparation method, and applications. The pH / hypoxia dual-responsive polymer is a hydroxyethyl deacetylated chitosan modified with p-nitrobenzyl chloroformate and cinnamaldehyde. Ropivacaine is loaded onto it and prepared into nanomicelles for use as a drug delivery system after tumor surgery. Due to its acid sensitivity and hypoxia response, it can intelligently identify the tumor microenvironment, achieving precise drug delivery.

The application relates to a synthesis method for constructing 2,4-imidazolidinedione compounds in a DNA coding compound library. The method takes 2-amino-N-acetamide compounds of On-DNA and p-nitrophenyl chloroformate as raw materials, reacts under the action of alkali, and obtains 2,4-imidazolidinedione compounds. The method has the advantages of mild reaction condition, simple operation, good substrate universality, good product yield and suitability for DNA coding compound synthesis in a multi-well plate.

The present application relates to the synthesis of pesticide compounds, in particular to a method for preparing a pyrasulfotole intermediate. The method comprises: (1) using p-chlorotoluene as a raw material, through nitration, chlorination, hydrolysis, or chlorination, hydrolysis, nitration, to obtain 3-nitro-4-chlorobenzaldehyde, (2) fluorination and reduction of 3-nitro-4-chlorobenzaldehyde to obtain 4-fluoro-3-amino benzaldehyde; (3) 4-fluoro-3-amino benzaldehyde is then contacted with chloroformate for reaction, and then chlorination to obtain compound IV; (4) compound IV is contacted with trifluorobutanamine ester under alkaline conditions for reaction to obtain compound I. The process for preparing compound I avoids using expensive raw material 2-chloro-4-fluorobenzoic acid, effectively reduces the cost of raw materials, reduces the three wastes generated in the process, and at the same time, the total yield of the reaction is high, and it is suitable for industrial mass production.

The invention discloses a preparation method of dodecyl chloroformate, which comprises the following steps: heating dodecanol to melt the dodecanol into a liquid state, introducing phosgene for reaction, reducing the reaction temperature to 0-20 DEG C in the reaction process, continuing the reaction until the content of the dodecanol in the reaction system is less than 0.5%, stopping introducing the phosgene, and keeping the temperature to obtain a reaction liquid; and heating the reaction liquid to 30 DEG C or above, introducing nitrogen, and removing impurities in the reaction liquid to obtain dodecyl chloroformate. Compared with the conventional method, the preparation method of dodecyl chloroformate can effectively improve the reaction conversion rate and selectivity by optimizing the reaction temperature of each stage in the reaction process, and can quickly and simply prepare high-yield and high-purity dodecyl chloroformate, the content is greater than or equal to 98%, the yield is greater than or equal to 98%, the product competitiveness can be improved, and the method is suitable for industrial production. The industrial application is convenient to realize and the industrial practicability is high.

The application discloses a method for continuously synthesizing isooctyl chloroformate, which comprises the following steps: preparing a continuous reaction device which comprises a photochemical tower, a transfer kettle and a chase light tower which are communicated with each other, feeding isooctanol and phosgene into the photochemical tower to perform a reaction, overflowing the obtained esterification liquid to the transfer kettle, performing gas-liquid separation on the obtained tail gas outside the tower, and feeding the liquid light into the tower; controlling the temperature of the transfer kettle at 30-40 DEG C, feeding the esterification liquid into the chase light tower after the transfer kettle collects a certain amount of esterification liquid, controlling the temperature of the chase light tower at 40-80 DEG C, feeding nitrogen into the chase light tower to perform chase light, and collecting high-purity isooctyl chloroformate in the chase light tower, wherein the content of the isooctyl chloroformate is greater than or equal to 99%, and the yield is greater than or equal to 97%. The method realizes continuous production under the premise of ensuring the quality and yield of the product, has small production land occupation, small liquid holdup of the reaction system, small risk, high production efficiency, easily controlled process conditions, little waste, accords with the green and environmental protection production concept, and is suitable for industrial production.

The invention belongs to the technical field of diisocyanate preparation, and particularly relates to a method for preparing diisocyanate from dihydric alcohol. The method for preparing diisocyanate from dihydric alcohol comprises the following steps: reacting dihydric alcohol with phosgene to generate aliphatic alkane diol di (chloroformate); the method comprises the following steps: heating and decomposing aliphatic alkane diol di (chloroformate) into dichloroalkane; enabling the dichloroalkane to react with liquid ammonia to generate aliphatic primary diamine; and reacting the aliphatic primary diamine with phosgene to generate diisocyanate. According to the method, low-cost 1, 4-butanediol or 1, 5-pentanediol is used as a raw material, diisocyanate is prepared through phosgenation, thermal decomposition, ammonification and secondary phosgenation, the technical effects of mild reaction conditions, high yield and reduction of raw material cost are achieved, meanwhile, reaction byproducts can be recycled, and the method is suitable for industrial production. The technical problems that a traditional process depends on an expensive diamine raw material, reaction conditions are harsh, and continuous production is difficult are solved.

The present invention belongs to the technical field of organic peroxides, and particularly relates to a preparation method of tert-amyl peroxy (2-ethylhexyl) carbonate. The preparation method comprises the following steps: (1) carrying out a temperature-controlled reaction on a crude product of tert-amyl hydroperoxide and a salifying agent under the action of a phase transfer agent to obtain an intermediate; (2) compounding a phase transfer catalyst system, blending the phase transfer catalyst system with 2-ethylhexyl chloroformate, and adding the blend and the intermediate into a reaction kettle in a co-current manner to carry out a substitution reaction. After the substitution reaction is completed, standing and collecting the upper organic phase to obtain a crude TAEC product; (3) adding a detergent to the crude TAEC product, stirring, standing, collecting the upper oil phase, and washing with water until the oil phase is neutral to obtain TAEC. By compounding the phase transfer catalyst system, the present invention solves the problems of many by-products of dicarbonates, low yield of TAEC and difficult catalyst recovery existing in the current TAEC synthesis method.

The invention belongs to the technical field of peroxide preparation, and particularly relates to a heat exchange device for peroxide preparation and a peroxide preparation method.The heat exchange device for peroxide preparation comprises a heat exchange pipe arranged in a reaction kettle, a plurality of heat exchangers are arranged on the heat exchange pipe, and each heat exchanger comprises a plurality of external fins; the external fins are arranged on the fixing plate at intervals, the fixing plate is provided with grooves matched with the heat exchange tubes, and the heat exchange tubes are arranged in the grooves of the fixing plate. The preparation method of the peroxide comprises the following steps: stirring a desensitizer, a catalyst and an oxidant for reaction, then adding alkyl acyl chloride or alkyl chloroformate for continuous reaction, and obtaining a crude product after the reaction is finished; and washing and separating the crude product to obtain the peroxide. The high-efficiency heat transfer performance can be realized by utilizing the heat exchanger, so that the peroxide product can be stably prepared, the charging reaction time is shortened, and the conversion efficiency from the initial raw material to the peroxide product is improved.

The invention belongs to the technical field of bacteria detection, and discloses an analysis method for detecting colistin in bacteria. The method comprises the following steps: firstly, centrifugally washing bacterial suspension incubated by sub-bacteriostasis colistin, and repeatedly freezing and thawing by adopting liquid nitrogen, so that bacterial cells are cracked; placing the split thalli in an acidic solution, and hydrolyzing at 60-120 DEG C in a protective atmosphere to obtain 2, 4-diaminobutyric acid; adjusting the pH to be neutral by using an alkaline solution to obtain hydrolysate; adding a derivatization buffer solution and a derivatization agent chloroformic acid-9-fluorenyl methyl ester into the hydrolysate, reacting at 20-80 DEG C to obtain a derivatization reaction solution, and treating to obtain filtrate; and separating the filtrate through a C8 reversed-phase chromatographic column, determining by selecting a fluorescence detector, and qualitatively and quantitatively analyzing the colistin in the bacteria by adopting a standard addition method, so that the colistin in the bacteria can be detected. According to the method, the colistin in the bacteria is detected by using a high performance liquid chromatography-fluorescence method, and a technical support is provided for exploring an antibacterial action mechanism of the colistin and a drug resistance mechanism of the bacteria.

The present invention relates to the technical field of metal processing, and specifically to a preparation method and application of an alkaline degreasing agent. It includes the following steps: Step 1: First, cholesterol chloroformate and cysteamine undergo an ammonolysis reaction, then a click reaction with ethylene oxide, and finally polymerization is initiated to obtain surfactant A; Step 2: First, cholesterol chloroformate and bis(2-aminophenyl) disulfide undergo an ammonolysis reaction, and then an alcoholysis reaction with tea polyphenols to obtain surfactant B; Step 3: Prepare a chelating agent; formulate to obtain the alkaline degreasing agent. The alkaline degreasing agent includes the following components: The content of each component is: 5-15 g / L of sodium hydroxide, 10-20 g / L of sodium carbonate, 30-100 g / L of sodium phosphate, 5-7 g / L of sodium pyrophosphate, 2-5 g / L of sodium gluconate, 20-30 g / L of surfactant A, 10-20 g / L of surfactant B, 3-6 g / L of chelating agent, and the rest is deionized water.

The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to a preparation method of a lenvatinib intermediate. The present invention uses tert-butyl cyclopropylcarbamate as the starting material, and reacts with 4-amino-3-chlorophenol under the action of a catalyst to obtain the key intermediate of lenvatinib, 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea. This preparation method effectively avoids the use of reagents with strong toxicity such as chloroformate, making the reaction operation safer and more suitable for industrial scale-up production.

The invention belongs to the field of organic matter preparation, and particularly relates to a preparation method of 9-fluorenyl methyl-N-succinimido carbonic ester, which comprises the following steps: dissolving N-hydroxysuccinimide, mixing with dried chloroformic acid-9-fluorenyl methyl ester and silicon-based solid alkali to react, quenching and washing after the reaction is completed, drying and purifying to obtain the 9-fluorenyl methyl-N-succinimido carbonic ester. The 9-fluorenyl methyl-N-succinimido carbonic ester is subjected to a reaction to obtain 9- The solid alkali is doped with ester groups. According to the method, the high-quality and high-purity product can be obtained, the requirement of a high-precision experiment for the product purity can be met, and the method is easy to operate and suitable for industrial popularization.

The application belongs to the field of organic matter preparation, and particularly relates to a preparation method of 9-fluorenylmethyl-N-succinimidyl carbonate, wherein N-hydroxy succinimide is dissolved and mixed with dry chloroformate-9-fluorenylmethyl ester and a silicon-based solid base for reaction, water is used for quenching and washing after the reaction is completed, and 9-fluorenylmethyl-N-succinimidyl carbonate is obtained after drying and purification; an ester group is doped on the solid base. The method can obtain high-quality and high-purity products, can meet the demand of high-precision experiments on product purity, and is simple to operate and suitable for industrial promotion.

The invention relates to the technical field of antioxidants. The antioxidant comprises an antioxidant, a supported emulsifier, a defoaming agent and deionized water, the preparation method of the supported emulsifier comprises the following steps: (1) reacting N, N-dimethyl ethylenediamine, acryloyl chloride and bromododecane to obtain acrylamide ethyl dimethyl octyl ammonium bromide; (2) enabling the 1, 2-bis (3-aminopropyl)-1, 1, 3, 3-tetramethyldisiloxane to react with allyl chloroformate, so as to obtain a silicon-containing diallyl monomer; (3) carrying out photo-initiation polymerization on a silicon-containing diallyl monomer, methoxyl polyethylene glycol-sulfydryl and N, N-dimethylacryloyl ethylenediamine, and then carrying out dialysis treatment, so as to obtain a cationic amphiphilic polymer; and (4) loading the cationic amphiphilic polymer onto the nanoscale talcum powder to obtain the loaded emulsifier. The supported emulsifier prepared by the invention is good in emulsifying effect, high in stability of an emulsion antioxidant, free of precipitation and layering phenomena after long-term storage, and excellent in oxidation resistance.

Biodegradable, controlled release microcapsules whose microcapsule walls comprise the reaction product of fractured plant proteins with isocyanates and / or bis- or poly- chloroformates.

This invention belongs to the field of organic synthesis technology and relates to a method for preparing (S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-en-1-yl isobutyrate. 2,4-Difluoroiodobenzene reacts sequentially with allyl alcohol and tert-butyl chloroformate to obtain 2-(2,4-difluorophenyl)allyl tert-butyl carbonate. Under the action of a palladium catalyst and Sadphos chiral phosphine ligand, the 2-(2,4-difluorophenyl)allyl tert-butyl carbonate undergoes alkylation and reduction to obtain (S)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)pent-4-en-1-yl isobutyrate. This invention utilizes a palladium catalyst and Sadphos chiral phosphine ligand to precisely construct a chiral center in one step, achieving an enantioselectivity of up to 99.4% and an overall yield of 65-70%. The operation is simple, the catalyst is recyclable, significantly reducing production costs and making it suitable for industrial production.

The utility model provides a chloroformate synthesis reactor. The chloroformate synthesis reactor comprises a tower body and a tower kettle, the top of the tower body is provided with a tail gas outlet, the upper end of the side wall is provided with a chloroformate overflow discharge port, and the outer side is provided with a cooling jacket; a cooling jacket is arranged on the outer side of the tower kettle, a feeding hole is formed in the bottom, and a distribution plate and a cooler are arranged in an inner cavity; the feed port is of a sleeve structure and comprises an inner pipe and an outer pipe, the inner pipe is an alcohol feed port, and the outer pipe is a phosgene feed port; the distribution disc comprises a horizontally arranged annular pipe, a connecting pipe for communicating the annular pipe with the phosgene feeding hole, and a plurality of gas outlet nozzles communicated with the annular pipe; and the cooler is positioned above the distribution disc. The chloroformate synthesis reactor disclosed by the utility model is reasonable in structural design, can realize rapid and uniform mixing of phosgene and alcohol raw materials, improves the reaction rate, avoids the situation of side reaction caused by local excessive alcohol, and improves the product quality.

The invention discloses a method for preparing fluoroformate, which comprises the following steps: by taking chloroformate as a raw material and hydrogen fluoride as a fluorination reagent, mixing chloroformate steam and hydrogen fluoride gas, and performing gas-phase catalysis on the chloroformate and hydrogen fluoride to generate fluorination reaction through a fixed bed reactor filled with a catalyst to obtain the fluoroformate, the catalyst is characterized in that at least one of active components of lithium fluoride, potassium fluoride, sodium fluoride, rubidium fluoride or cesium fluoride is loaded on at least one of carriers of activated carbon, aluminum fluoride, magnesium fluoride, ferric fluoride, chromium fluoride and zinc fluoride, the mass percentage ratio of the active components to the carriers of the catalyst is 10-50%: 50-90%, the reaction temperature is 200-400 DEG C, and the retention time is 10-60 s. The method has the advantages of greenness, high efficiency, continuous catalysis and the like.

The utility model discloses an isooctyl chloroformate continuous production device, the device comprises a synthesis unit and a deacidification unit which are communicated through a pipeline, the synthesis unit comprises a photochemical tower, a tail gas condenser and a crude product buffer tank, the side part of the photochemical tower is provided with an isooctyl alcohol inlet, a liquid light inlet and a crude product outlet, the crude product outlet is connected with a crude product buffer tank through a pipeline, the bottom of the tail gas condenser is provided with a shared port of a tail gas inlet and a liquid-light outlet, and the liquid-light outlet is connected with a liquid-light inlet of the photochemical tower through a liquid-light backflow pipeline; the deacidification unit comprises a falling film evaporator, a gas-liquid separation tank and a finished product temporary storage tank, the top of the falling film evaporator is communicated with the crude product buffer tank through a pipeline, the lower side of the falling film evaporator is communicated with the gas-liquid separation tank through a pipeline, and the bottom of the falling film evaporator is communicated with the top of the finished product temporary storage tank through a pipeline. The device can realize continuous synthesis and deacidification of isooctyl chloroformate, and is low in phosgene consumption, high in product yield, safe and environment-friendly.

This application relates to the technical field of organic light-emitting materials, and particularly to a chiral light-emitting molecule and its preparation method, as well as a chiral light-emitting liquid crystal. The preparation method of the chiral light-emitting molecule includes the following steps: S1: Menthyl chloroformate, 4-phenol-2,1,3-benzothiadiazole, palladium catalyst, and acid-binding agent are sequentially added to a flask, followed by the addition of an organic solvent for dissolution and thorough stirring to obtain a mixture; S2: The mixture is injected into a nitrogen-filled reaction vessel, heated to 70–95°C, reacted for 5–10 hours, and then separated and purified to obtain the chiral light-emitting molecule. Compared with traditional preparation methods such as alkylation, acylation, dehydration, and ring-opening methods, the preparation method of this application significantly shortens the reaction time while increasing the yield; furthermore, this method is simple to operate, the reaction is mild, and it can be carried out under conventional laboratory conditions, reducing the cost of chiral light-emitting molecules.

The present invention provides a method for synthesizing a phenanthroimidazole-based fluorescent amine compound labeling reagent and its application, belonging to the technical field of fluorescent labeling of organic small molecule amine compounds. Using phenanthroimidazole as the parent ring and chloroformate as the reactive group, the chemical name is: 4-(N-phenylphenanthroimidazolyl)-benzyl chloroformate. The specific preparation method is as follows: (1) React phenanthraquinone, aniline, p-hydroxymethylbenzaldehyde, and ammonium acetate to obtain an intermediate; (2) Hydrolyze the intermediate with an aqueous potassium hydroxide solution to obtain the intermediate product 4-(N-phenylphenanthroimidazolyl)-benzyl alcohol; (3) React the intermediate product with triphosgene to obtain the target product. The present invention can quickly, accurately, and sensitively label 10 kinds of aliphatic amines, thereby realizing the separation and detection of trace aliphatic amines in complex systems, and can be used for the fluorescent labeling and analysis of various aliphatic amines in research fields such as life and food, and has broad application prospects.