37 results about "Severe toxicity" patented technology

A method of manipulating allogeneic cells for use in allogeneic cell therapy protocols is described. The method provides a composition of highly activated allogeneic T-cells which are infused into immunocompetent cancer patients to elicit a novel anti-tumor immune mechanism called the “Mirror Effect”. In contrast to current allogeneic cell therapy protocols where T-cells in the graft mediate the beneficial graft vs. tumor (GVT) and detrimental graft vs. host (GVH) effects, the allogeneic cells of the present invention stimulate host T-cells to mediate the “mirror” of these effects. The mirror of the GVT effect is the host vs. tumor (HVT) effect. The “mirror” of the GVH effect is the host vs. graft (HVG) effect. The effectiveness and widespread application of the anti-tumor GVT effect is limited by the severe toxicity of the GVH effect. In the present invention, the anti-tumor HVT effect occurs in conjunction with a non-toxic HVG rejection effect. The highly activated allogeneic cells of the invention can be used to stimulate host immunity in a complete HLA mis-matched setting in patients that have not had a prior bone marrow transplant or received chemotherapy and / or radiation conditioning regimens.

The invention discloses an imide group-containing polymer foam material and a preparation method thereof. The preparation method comprises the following steps that one or two ester group-containing propylene monomers, one or two amido group-containing propylene monomers, one or more polymerization initiators, a mixed foaming agent, one or more cross-linking agents and one or two solvents are added into a reactor and undergo a continuous reaction to form sticky substances; the sticky substances obtained from the previous step are treated by processes of washing, filtering and drying; the driedsticky substances obtained from the previous step are grinded into copolymer powder; and the copolymer powder is putted into a mould and are treated by a series of processes to form finished products. In the invention, (methyl) acrylonitrile with a severe toxicity is not utilized, and moulds can be designed according to shapes of finished products thus a foam material in any shape can be obtainedwithout being cut so that a cellular structure of the foam material is not damaged; related properties of the foam material are not reduced; and an application scope of the foam material is greatly widened. The imide group-containing polymer foam material prepared through the preparation method can be widely and directly utilized in the fields of aviation and spaceflight, carrier rockets, railwaylocomotives, ships, wind generator blades, sports goods and the like.