37 results about "Severe toxicity" patented technology

The invention relates to a synthetic method of an MWW structured Si / B molecular sieve and mainly solves problems of severe toxicity of a template or complex preparation in the prior art. The synthetic method provided by the invention comprises the following steps: mixing a boron source, a silicon source, alkaline MOH, a template R and water, wherein the mol ratio of the mixture is B2O3:SiO2:OH-:R:H2O=(0.01-1.00):1:(0.02-0.30):(0.01-0.50):(5-50); carrying out hydrothermal crystallization on the above mixture at the temperature of 100-200 DEG C for 1-10 days; separating, washing and drying to obtain the MWW structured Si / B molecular sieve, wherein the template R is diethyldimethylammonium hydroxide. The technical scheme can be applied in industrial production of the MWW structured Si / B molecular sieve.

A method of manipulating allogeneic cells for use in allogeneic cell therapy protocols is described. The method provides a composition of highly activated allogeneic T-cells which are infused into immunocompetent cancer patients to elicit a novel anti-tumor immune mechanism called the “Mirror Effect”. In contrast to current allogeneic cell therapy protocols where T-cells in the graft mediate the beneficial graft vs. tumor (GVT) and detrimental graft vs. host (GVH) effects, the allogeneic cells of the present invention stimulate host T-cells to mediate the “mirror” of these effects. The mirror of the GVT effect is the host vs. tumor (HVT) effect. The “mirror” of the GVH effect is the host vs. graft (HVG) effect. The effectiveness and widespread application of the anti-tumor GVT effect is limited by the severe toxicity of the GVH effect. In the present invention, the anti-tumor HVT effect occurs in conjunction with a non-toxic HVG rejection effect. The highly activated allogeneic cells of the invention can be used to stimulate host immunity in a complete HLA mis-matched setting in patients that have not had a prior bone marrow transplant or received chemotherapy and / or radiation conditioning regimens.

The invention discloses an imide group-containing polymer foam material and a preparation method thereof. The preparation method comprises the following steps that one or two ester group-containing propylene monomers, one or two amido group-containing propylene monomers, one or more polymerization initiators, a mixed foaming agent, one or more cross-linking agents and one or two solvents are added into a reactor and undergo a continuous reaction to form sticky substances; the sticky substances obtained from the previous step are treated by processes of washing, filtering and drying; the driedsticky substances obtained from the previous step are grinded into copolymer powder; and the copolymer powder is putted into a mould and are treated by a series of processes to form finished products. In the invention, (methyl) acrylonitrile with a severe toxicity is not utilized, and moulds can be designed according to shapes of finished products thus a foam material in any shape can be obtainedwithout being cut so that a cellular structure of the foam material is not damaged; related properties of the foam material are not reduced; and an application scope of the foam material is greatly widened. The imide group-containing polymer foam material prepared through the preparation method can be widely and directly utilized in the fields of aviation and spaceflight, carrier rockets, railwaylocomotives, ships, wind generator blades, sports goods and the like.

The invention belongs to the technology field of traditional Chinese medicine, in particular to a traditional Chinese medicine for activating blood circulation, dredging vessels and benefiting wisdom which is used for the treatment of vascular dementia, thus solving the problems of limited efficacy, severe toxicity and side effects and expensive cost of the medicine for the treatment of vascular dementia in the prior art. The traditional Chinese medicine for activating blood circulation, dredging vessels and benefiting wisdom which is used for the treatment of vascular dementia takes grassleaf sweelflag rhizome, danshen root, tuber fleeceflower root, membranous milkvetch root, Chinese angelica, wild hawthorn fruit and epimedium herb as sovereign medicines. Tall gastrodia tuber, cassia seed, oriental waterplantain rhizome, kudzuvine root and stewed rhubarb are taken as auxiliary materials. The medicine of the invention can improve the memory, know the symptoms, or have certain efficacies on the aspects of spirit antagonism and behavior obstacles, regulate blood pressure, blood lipids, blood glucose and blood rheology, inhibit peroxide substances, improve neurotransmitter conductionand free radical metabolism and have the inhibition of the development of vascular sclerosis, so the medicine can be used for the prevention and the treatment of vascular dementia.

The invention discloses an industrialization preparation method for RDG peptide. The technical scheme of the present invention comprises the following steps: Wang resin is taken as an initial raw material and TBTU / HOBt is taken as a condensing agent, amino acid possessing a Fmoc-protective group is successively connected according to a solid phase synthesis method, Boc-Arg-OH.HCl is used by a last amino acid to obtain protective tripeptide resin, and meanwhile crude products are obtained by sequentially removing Fmoc-protective groups synchronized with acellular side-chain protective groups and cutting peptides, and the RDG peptide elaborate products are prepared after the crude products are separated and purified by a C18 high performance liquid phase column and freeze-dried. The method of the invention is capable of reducing the production cost and simplifying the process flow. The crude products can be deposited by ether after cutting peptides so that the usage of hydrogen fluoride with severe toxicity can be avoided and the three wastes pollution is reduced. C18 column is used for separating and purifying to avoid the usage of trifluoroacetic acid and reduce three wastes. The purification yield is more than 50%, the each step of transpeptidase yield is more than 98%, the yield after cutting peptides is 88%, the separation and purification yield is 58% and the overall yield is 51%. The method of the present invention is convenient for industrial enforcement and has large industrialization prospect.