37 results about "Severe toxicity" patented technology

A method of manipulating allogeneic cells for use in allogeneic cell therapy protocols is described. The method provides a composition of highly activated allogeneic T-cells which are infused into immunocompetent cancer patients to elicit a novel anti-tumor immune mechanism called the “Mirror Effect”. In contrast to current allogeneic cell therapy protocols where T-cells in the graft mediate the beneficial graft vs. tumor (GVT) and detrimental graft vs. host (GVH) effects, the allogeneic cells of the present invention stimulate host T-cells to mediate the “mirror” of these effects. The mirror of the GVT effect is the host vs. tumor (HVT) effect. The “mirror” of the GVH effect is the host vs. graft (HVG) effect. The effectiveness and widespread application of the anti-tumor GVT effect is limited by the severe toxicity of the GVH effect. In the present invention, the anti-tumor HVT effect occurs in conjunction with a non-toxic HVG rejection effect. The highly activated allogeneic cells of the invention can be used to stimulate host immunity in a complete HLA mis-matched setting in patients that have not had a prior bone marrow transplant or received chemotherapy and/or radiation conditioning regimens.

The invention relates to fluorine contained miazines compound N-4 position alkyl oxygen carbonyl acidylating method, and its use in composing antineoplastic medicine-capecitabine. The invention has the advantages of avoiding using severe toxicity reagent such as, chloro formate, or phosgene etc, stable and easily gaining raw material, easy industrialization operation etc.

The invention provides a plating solution for the non-cyanide imitation gold plating of a Cu-Zn binary alloy on low carbon steel, and its use method in order to improve the problems of severe toxicity, bad anode dissolvability and high treatment cost of three wastes of cyanide-containing plating solutions and the problems of complex composition, narrow range of technological parameters and unrealistic imitation gold color of non-cyanide plating solutions in present imitation gold plating technologies. The method is characterized in that the method comprises the following steps: an activated matrix can be directly plated without cleaning, so the operation is simple; the imitation gold plating solution is composed of potassium pyrophosphate, copper sulfate, zinc sulfate and glycerin, so the imitation gold plating solution has the advantages of green property, environmental protection, good dispersity, strong homogeneous plating ability, simple composition and easy maintenance; and the prepared gold imitation plating solution can meet the requirements of the cross cut test requirements of national standard GB9286-1998 paint and varnish film; and the obtained coating is passivated and seal-protected, and the protected coating meets the 5% brine neutral salt spray test indexes of the national standard GB5938-86 Corrosion Resistance Test Method of Metal Coating and Chemical Treatment Layer of Light Industrial Product, and can be used as a decorative coating.

The invention relates to a preparation method of pitavastatin calcium for treating hyperlipidemia. The preparation method comprises the following steps: performing cyclization on 2-amino-4'-fluorobenzophenone (III) and ethyl 3-cyclopropyl-3-oxo-propanoate (II), and then reducing with LiAlH4 to obtain 2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline methanol (V); bromizing the V to obtain 2-cyclopropyl-3-bromomethyl-4-(4-fluorophenyl) quinoline (VI); reacting the VI with triphenylphosphine to obtain (2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-yl) methyltriphenylphosphonium bromide (VII), performing alkali treatment on a phosphonium salt, then forming phosphonium ylide, performing condensation with (3R, 5S)-6-oxo-3, 5-isopropylidene-dioxo-6-heptenoic acid tert-butyl ester (VIII) to obtain a compound IX; and acidifying the compound IX with hydrochloric acid, performing hydrolysis deprotection with sodium hydroxide, performing salt formation and purification with chiral amine and forming a calcium slat to obtain a final product. The whole route has reasonable design, the process flow is simple, starting raw materials and reagents used by the preparation method can be purchased from the market, the reagents with severe toxicity and serious pollution are not used in a reaction process, the post-treatment of an intermediate is simple, and the preparation method has the advantages of high yield and is easy to purify.

The invention discloses a two-dimensional code type chemical toxicity information building and searching method. Biophysical-chemical information and biological toxicity information of chemicals are collected, information introduction is simplified, the chemicals are divided into four types including severe toxicity, high toxicity, middle toxicity and low toxicity, hazard classes of the toxicity of the chemicals to human bodies are calculated by a comprehensive index method according to chemical toxicity classification grades, a simple chemical toxicity information list not exceeding 140 characters is generated according to the biophysical-chemical information and biological toxicity grade information of the chemicals, the simple chemical toxicity information list is converted into two-dimensional codes with different sizes through a two-dimensional code converter, the two-dimensional codes are laminated and pasted on a chemical outer package, an APP (application) is scanned by the two-dimensional codes on handheld wireless mobile terminals such as a smart phone with a scanning function, chemical users rapidly, simply and conveniently acquire, store and spread the toxicity information of the chemicals at low cost, and toxicity warning and health protection functions are achieved.

The invention relates to a double line rectification method of hexafluoropropene production cracking gas, and a rectification apparatus thereof. The double line rectification method adopting 6 rectifications and two-time compression is carried out to separate light components from heavy components and separate low toxicity components and severe toxicity components, and new technologic control parameters are adopted, so the quantity of devices containing severe toxicity octafluoroisobutylene is greatly reduced, the safety level of the apparatus is improved, the HFP (hexafluoropropene) product quality is improved, energy consumption is reduced, the production power of the apparatus is improved, the production cost is reduced, the apparatus utilization efficiency is improved, the unit consumption is reduced, and the apparatus and the method have very high safety, environmental protection energy saving and consumption reduction benefits.

The invention relates to a method for enhancing oxidization leaching of low-valence arsenic existed as an alloy form of arsenic copper, arsenic cobalt and arsenic nickel in arsenic-cobalt-nickel containing slag by taking NaOH or KOH solution as a leaching medium and taking a copper oxide as an oxidizing agent. In the method, on one hand, an alkali medium is taken as the leaching medium, thereby the risk of generation of arsine gas with severe toxicity can be avoided during acid leaching; on the other hand, the copper oxide is taken as the oxidizing agent, by comparing with oxygen pressure leaching of the alkali medium, operation pressure of a system is reduced, copper in the copper oxide can not be dissolved in the alkali medium, and can follow with copper in the arsenic-cobalt-nickel containing slag into a copper smelting system. The method is the further improvement of a pressure oxidation leaching-out method for the alkali medium.

The invention relates to the technical field of synthesis of inorganic nonmetal materials, and aims at providing a method for compounding pyroxene-type microcrystalline glass materials by means of solid waste such as ferrochrome slags and waste glass, limestone, sodium carbonate and fluorite. The raw materials used for compounding mainly adopt the solid waste, and the ferrochrome slags belong to waste with severe toxicity and need to be treated individually. The waste microcrystalline glass materials are compounded only by means of normal pressed sintering, all performances meet needs of industrial production, the problem that the environment is polluted due to the fact that a large amount of solid waste is stacked is solved, the compounded waste slag type microcrystalline glass materials can be applied to building decoration materials, the method for compounding the pyroxene-type microcrystalline glass materials by means of the solid waste such as the ferrochrome slags and the waste glass, the limestone, the sodium carbonate and the fluorite accords with the industrial policy of circular economy advocated by the nation, and higher economic value and environmental significance are achieved.

The invention belongs to the technology field of traditional Chinese medicine, in particular to a traditional Chinese medicine for activating blood circulation, dredging vessels and benefiting wisdom which is used for the treatment of vascular dementia, thus solving the problems of limited efficacy, severe toxicity and side effects and expensive cost of the medicine for the treatment of vascular dementia in the prior art. The traditional Chinese medicine for activating blood circulation, dredging vessels and benefiting wisdom which is used for the treatment of vascular dementia takes grassleaf sweelflag rhizome, danshen root, tuber fleeceflower root, membranous milkvetch root, Chinese angelica, wild hawthorn fruit and epimedium herb as sovereign medicines. Tall gastrodia tuber, cassia seed, oriental waterplantain rhizome, kudzuvine root and stewed rhubarb are taken as auxiliary materials. The medicine of the invention can improve the memory, know the symptoms, or have certain efficacies on the aspects of spirit antagonism and behavior obstacles, regulate blood pressure, blood lipids, blood glucose and blood rheology, inhibit peroxide substances, improve neurotransmitter conduction and free radical metabolism and have the inhibition of the development of vascular sclerosis, so the medicine can be used for the prevention and the treatment of vascular dementia.

The invention relates to a Dapagliflozin preparation method, which comprises the following steps: using 2-chlorobenzaldehyde as a starting material, carrying out bromination, reducing, chlorinating tosynthesize 5-bromo-2-chlorobenzyl chloride, carrying out Friedel-Crafts alkylation reaction between 5-bromo-2-chlorobenzyl chloride and phenetole to synthesize 5-bromo-2-chloro-4'-ethyoxyldiphenylmethane, conducting condensation between 5-bromo-2-chloro-4'-ethyoxyldiphenylmethane and 2,3,4,6-tetra-O-trimethylsilyl-D-glucolactone, carrying out trimethylsilyl deprotection, conducting etherification, and reducing for demethylation to obtain a hypoglycemic drug Dapagliflozin. The invention has the following advantages: according to the Dapagliflozin preparation method, 2-chlorobenzaldehyde, whichis used as a starting material, is cheaper and easily available in comparison with 5-bromo-2-chlorobenzoic acid, and the technology is easy for industrialization; during the synthetic process, no rawmaterials which cause severe toxicity will be used and furthermore there is no dangerous process; the synthetic route is short and novel and the operation is simple; and through the synthetic route,purity of the final product can be raised, and the purity can reach 99% and above.

The invention discloses a rapid analysis method for main salts in a zinc-nickel electroplating solution. According to the invention, an alkaline galvanized nickel alloy electroplating solution is analyzed, and the total content of zinc and nickel ions in the electroplating solution is calculated by selecting a determination method directed at the chemical properties of the electroplating solution to titrate main components in the electroplating solution and determining the volume of a titration reagent according to color changes, precipitation and the like of the electroplating solution; and then the content of nickel ions in the electroplating solution is determined through usage of spectrophotometry, and the contents of zinc and nickel ions are calculated, so changes are made to a conventional standard determination method using cyanide with severe toxicity. Compared with the standard determination method, a novel determination process is established, and thorough cyanide elimination is realized in the alkaline galvanized nickel alloy electroplating industry.

The invention provides a method for preparing 2-chloro-4-fluorobenzonitrile. The method comprises the following steps: using 2-chloro-4-nitrobenzonitrile and potassium fluoride as raw materials and dialkylacetamide or dialkyl sulfoxide as a solvent to generate a reaction mixture containing the 2-chloro-4-fluorobenzonitrile at a certain temperature by adopting a quaternary alkylphosphonium salt as a catalyst; the reaction mixture adopts a saturated alkane extraction method; and an extraction liquid is rectified at the reduced pressure to obtain the required product 2-chloro-4-fluorobenzonitrile. The method has the advantages that the process route is simple; the raw materials are accessible and cheap, do not have severe toxicity, have strong stability, and do not pollute the environment; the purity of the product 2-chloro-4-fluorobenzonitrile is more than 99 percent, and yield of the product is over 80 percent; and high reaction selectivity reaches over 90 percent.

The invention provides a Chinese herbal oil solution for treating burns and a preparation method thereof, belonging to the field of pharmacy and medical technology in traditional Chinese medicine. The Chinese herbal oil solution comprises the following raw materials by weight: 7 to 15 parts of centella, 7 to 15 parts of dahurian angelica root, 7 to 15 parts of bletilla rhizomes, 7 to 15 parts of Chinese rhubarb, 7 to 15 parts of Chinese ilex leaves, 7 to 15 parts of Biota orientalis, 7 to 15 parts of honeysuckle flowers, 12 to 18 parts of lithospermum, 5 to 10 parts of frankincense, 5 to 10 parts of myrrh, 4 to 8 parts of dragon's blood, 7 to 15 parts of catechu, 1 to 5 parts of borneol and 130 to 180 parts of sesame oil. The Chinese herbal oil solution provided by the invention has antibacterial, anti-inflammation, detumescent, pain-relieving, pus-expelling, astringing, flesh-engendering and scar-growth-inhibiting effect, and has good effect on third-degree burn wound and infection wounds with diameters of less than 12 cm, second-degree burns, soft tissue contusion, bedsores and burns caused by pesticides and chemicals with severe toxicity; the Chinese herbal oil solution allows a healed wound to be free of obvious protruding or recessed scars, is short in treatment period, simple and easily practicable; and when a dressing for a wound is to be changed during outpatient service, the Chinese herbal oil solution causes little pain and is low in cost.

The invention relates to a halogen-free burning resistant adhesive plaster and its manufacturing method. The manufacturing method comprises the following steps of: firstly forming epoxy natural adhesive paste on the surface of base cloth and then pasting a halogen-free natural adhesive plaster on the surface of the base cloth by the use of the epoxy natural adhesive paste to finish the manufacturing. The above halogen-free natural adhesive plaster is made from a halogen-free natural adhesive material which contains a phosphorus burning resistant agent and an inorganic burning resistant filler. By the mutual cooperative effect of the phosphorus burning resistant agent and the inorganic burning resistant filler, the expected burning resistant effect is achieved; in addition, the halogen-free burning resistant adhesive plaster can replace a halogen burning resistant adhesive agent so as to avoid severe symptoms in human body such as poor metabolism, immune function disorder and the like due to severe toxicity of halogen.

The invention relates to the technical field of chemical industry, and discloses an epoxiconazole preparation method. The method comprises the following steps: adding fluorobenzene and a solvent in aglass reaction bottle equipped with a stirrer and a condenser, wherein the ratio of fluorobenzene to acetyl chloride is 1:15, selecting dichloroethanes as the solvent by taking regard of toxicity andcost, dropping dichloroethanes under stirring, controlling the reaction temperature for fully reacting the materials in a glass reaction bottle after 5 hours, after the reaction is completed, performing hydrolysis with hydrochloric acid, steaming excessive fluorobenzene by water vapor, and performing desolvation through solvent extraction to obtain the fluoroacetophenone. The preparation method ofthe epoxiconazole is characterized in that a synthesis route is integrally improved, the preparation method has the advantages of simple process, and low cost and easy acquisition of raw material, the epoxiconazole has high stereoselective performance, cannot generate high salt waste water, does not use severe-toxicity methanesulfonyl chloride, accords with environmental protection requirement, and is suitable for industrial production, and the yield and content of the final product are high.

The invention discloses a synthesis method of 8-hydroxyquinaldine. The synthesis method is characterized by comprising the steps of (1) fully dissolving o-aminophenol and o-nitrophenol in a mixed solution of hydrochloric acid and acetic acid at the temperature of 30-100 DEG C, slowly dropping paraldehyde at the temperature, and performing heat preservation reaction for 1-8h after the end of dropping; (2) removing unreacted o-nitrophenol by steam distillation, cooling the remaining solution to room temperature, neutralizing with an alkaline solution, and then filtering to obtain a solid crude product; (3) performing reduced pressure distillation and re-crystallization with an ethanol water solution to obtain a high-purity crystal product. According to the method disclosed by the invention, low-toxicity paraldehyde is used for replacing crotonaldehyde with severe toxicity, and the method has the advantages of simple process and low raw material cost, and is suitable for large-scale production.

The invention provides a preparation method of D-(-)-alpha-sulbenicillin sodium. The method comprises the following steps: taking alpha-sulfonylphenylacetic acid as an initial raw material, performinga reaction with carbonyl diimidazole to generate an acyl imidazoles acylating agent, and performing condensation with 6-APA to obtain a diastereomer of sulbenicillin; separating D-(-)-alpha-sulbenicillin by a recrystallization method, and forming salt with sodium hydroxide to obtain the D-(-)-alpha-sulbenicillin sodium. During a acid anhydrides preparation process, usage of a severe-toxicity substance is avoided, during a preparation process, recrystallization is used, and the optically pure D-(-)-alpha-sulbenicillin is prepared, cost is saved, operation is simplified, yield is increased, andthe method is in favor of industrial production and environment protection.

The invention provides an ECH-Fenton combined process for harmless degradation of dichlorophen, which belongs to the technical field of electrochemical water treatment. The process comprises the following steps: highly-efficiently degrading dichlorophen by using a Pd/PPy(SDBS)/Ti electrode with high catalytic activity; and then further degrading dichlorophen by using a Fenton reagent so as to realize harmless removal of dichlorophen. The ECH-Fenton combined process realizes 100% high-efficiency harmless degradation of the pollutant dichlorophen with severe toxicity.

The invention discloses an industrialization preparation method for RDG peptide. The technical scheme of the present invention comprises the following steps: Wang resin is taken as an initial raw material and TBTU/HOBt is taken as a condensing agent, amino acid possessing a Fmoc-protective group is successively connected according to a solid phase synthesis method, Boc-Arg-OH.HCl is used by a last amino acid to obtain protective tripeptide resin, and meanwhile crude products are obtained by sequentially removing Fmoc-protective groups synchronized with acellular side-chain protective groups and cutting peptides, and the RDG peptide elaborate products are prepared after the crude products are separated and purified by a C18 high performance liquid phase column and freeze-dried. The method of the invention is capable of reducing the production cost and simplifying the process flow. The crude products can be deposited by ether after cutting peptides so that the usage of hydrogen fluoride with severe toxicity can be avoided and the three wastes pollution is reduced. C18 column is used for separating and purifying to avoid the usage of trifluoroacetic acid and reduce three wastes. The purification yield is more than 50%, the each step of transpeptidase yield is more than 98%, the yield after cutting peptides is 88%, the separation and purification yield is 58% and the overall yield is 51%. The method of the present invention is convenient for industrial enforcement and has large industrialization prospect.