Epoxiconazole preparation method thereof

Abstract

The invention relates to the technical field of chemical industry, and discloses an epoxiconazole preparation method. The method comprises the following steps: adding fluorobenzene and a solvent in aglass reaction bottle equipped with a stirrer and a condenser, wherein the ratio of fluorobenzene to acetyl chloride is 1:15, selecting dichloroethanes as the solvent by taking regard of toxicity andcost, dropping dichloroethanes under stirring, controlling the reaction temperature for fully reacting the materials in a glass reaction bottle after 5 hours, after the reaction is completed, performing hydrolysis with hydrochloric acid, steaming excessive fluorobenzene by water vapor, and performing desolvation through solvent extraction to obtain the fluoroacetophenone. The preparation method ofthe epoxiconazole is characterized in that a synthesis route is integrally improved, the preparation method has the advantages of simple process, and low cost and easy acquisition of raw material, the epoxiconazole has high stereoselective performance, cannot generate high salt waste water, does not use severe-toxicity methanesulfonyl chloride, accords with environmental protection requirement, and is suitable for industrial production, and the yield and content of the final product are high.

Description

technical field [0001] The invention relates to the technical field of chemical industry, in particular to a preparation method of epoxiconazole. Background technique [0002] At present, most of the fungicides used in my country's agricultural production are old varieties of organosulfur, organophosphorus and triazoles such as triadimefon and triadimenol. As a result, the pollution to the environment is becoming more and more serious. Epoxiconazole is a new generation of triazole fungicides with high activity and broad spectrum, which has special effects on target diseases. [0003] The traditional preparation method of epoxiconazole is relatively complicated, and the requirements for the preparation environment of epoxiconazole are relatively high. When preparing epoxiconazole, users need to use complicated preparation equipment and various fine materials. Epoxiconazole often needs to concentrate and be careful, and a momentary mistake will lead to preparation failure, all...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a preparation method of epoxiconazole, which has the advantages of simple preparation method, etc., and solves the complicated preparation method of the traditional epoxiconazole, and the requirements for the preparation environment of epoxiconazole Higher, users need to use complicated preparation equipment and a variety of fine materials when preparing epoxiconazole, users often need to concentrate and be careful when preparing epoxiconazole, and a momentary mistake will lead to preparation failure, and all previous efforts will be wasted , loss of a large amount of consumables, users are very troubled by this problem