659 results about "Desolvation" patented technology

A heated DESI spray device provides improved resolution or control of analyte desorption at a target locus on a sample. Heating controls spot size and enhances resolution in an imaging mode without impairing signal level. Additionally or alternatively the heated DESI spray may control desorption kinetics of a target analyte or otherwise control analyte discrimination in detection mode. One embodiment of the DESI spray is heated by heating nebulizing gas that accompanies the electrosprayed solvent. Another embodiment heats a separate gas stream that transports or directs desorbed material to the ion aperture of an analysis instrument. Heating may reduce size of primary droplets, alter the impact dynamics or the energy delivered by the spray to the surface, reduce size of secondary droplets and / or assure desolvation, improve species selectivity or otherwise affect sampling and enhance the ion signal level.

The invention discloses equipment and a method for extracting biologically active ingredients from subcritical fluid, aims to solve the problems of low extraction efficiency and the like existing in the aspects of biologically active ingredient separation technology in the prior art and provides a set of subcritical equipment which comprises an extracting agent supply system, an entrainer supply system, an extraction system, a separation system, a solvent recycling system, a desolvation system, a heat supply system, a computer control system and the like, has high automatic control degree and is used for extracting the biologically active ingredients. Simultaneously, the invention also provides a new technological method for extracting the biologically active ingredients by adopting a subcritical extraction process. The method has the advantage of relatively low cost on the conventional extraction of an organic solvent, and the equipment has the characteristics of no solvent residue, no pollution, high bioactivity and the like in a product obtained by supercritical CO2 extraction technology and has the advantages of low investment on production equipment, high production efficiency within unit time, low energy consumption, flexible operation, high degree of automation and the like.

A method and apparatus for focusing ions for delivery to an ion detection device using an aerodynamic ion focusing system that uses a high-velocity converging gas flow at an entrance aperture to focus an ion plume by reducing spreading and increasing desolvation of ions, and wherein a voltage is applied to at least a portion of the aerodynamic ion focusing system to assist in the focusing and delivery of ions to the ion detection device.

An electrospray interface for forming ions from a liquid sample in a mass analyzing system includes a capillary tube having a free end for introducing a spray of droplets into an ionization chamber, a first gas passageway positioned near the capillary tube for directing a first gas stream into the ionization chamber, and a second gas passageway positioned more remotely from the capillary tube for directing a second, low-velocity gas stream into the ionization chamber. The second gas stream is heated to increase the droplet desolvation rate. A heated sampling capillary having an end extending into the ionization chamber guides the analyte ions toward a mass analyzer and evaporates the solvent from any incompletely desolvated droplets entering the sampling capillary.

A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m / z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

An electrospray interface for forming ions from a liquid sample in a mass analyzing system includes a capillary tube having a free end for introducing a spray of droplets into an ionization chamber, a first gas passageway positioned near the capillary tube for directing a first gas stream into the ionization chamber, and a second gas passageway positioned more remotely from the capillary tube for directing a second, low-velocity gas stream into the ionization chamber. The second gas stream is heated to increase the droplet desolvation rate. A heated sampling capillary having an end extending into the ionization chamber guides the analyte ions toward a mass analyzer and evaporates the solvent from any incompletely desolvated droplets entering the sampling capillary.

A disclosed preparation method for an organosilicon-modified crosslinking polyurethane emulsion is characterized in that: employing diisocyanate, an oligomer polyol, a hydrophilic chain extender and a chain extender to prepare a polyurethane prepolymer, then using a silane coupling agent for end sealing, then adding hydroxyl silicone oil, after reaction, performing cooling, emulsification and pressure-reducing desolvation to obtain the organosilicon-modified crosslinking polyurethane emulsion. According to the preparation method, the silane coupling agent not only helps to combine organosilicon and polyurethane, but also helps to substantially improve crosslinking degree of the material as a cross-linking agent. The emulsion prepared by the invention is good in stability, green and environment-friendly; and the prepared polyurethane film has the advantages of high mechanical strength, low-temperature resistance, good water proofness and the like, and is widely applicable to the fields of paints, fabric coating glues, leather finishing agents, adhesives and the like.

An inexpensive electrospray mass spectrometer capable of performing measurements consecutively from the ESI mode to the cold-spray ionization mode and vice versa. The electrospray mass spectrometer has an electrospray ion source, a nebulization nozzle, and a sampling orifice. The axes of the nozzle and orifice intersect each other. The instrument has a movable cold-spray desolvation chamber. In the electrospray ionization mode, the desolvation chamber is placed off the axis of the nebulization nozzle. In the cold-spray ionization mode, the desolvation chamber is set on the axis of the nebulization nozzle.

Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets. When the droplets are sufficiently small, Stokes drag from the exiting solvent vapor carries the droplets out through the center of the cylindrical cavity. After exiting, the superheated solvent vapor further dries the droplets. Solvent vapor is removed by condensation onto a cooled surface. A freezing point reducing agent may be added to improve removal of solvent condensate. Stokes drag from a non-condensable gas maintains the dried droplets in suspension. This suspension travels through an orifice that focuses the impaction of the dried droplets onto the optical surface for infrared analysis. The deposition surface is in an evacuated chamber and is temperature controlled to freeze liquid solutes yet allowing sublimation of residual solvent.

The invention relates to a method for preparing through-hole foam copper, in particular to the manufacture of metal with an opened or a closed hole. Electrolytic copper powder and NaCl granules are taken as raw materials, and sintering-desolvation technology is adopted for preparing the through-hole foam copper; the NaCl granules, the electrolytic copper powder and additive are evenly mixed together and then pressed into green-ware; the obtained green-ware is sintered in a sintering furnace under the argon atmosphere, and the obtained product is placed into a circulating hot water device to dissolve and remove the NaCl granules and then washed by ultrasonic wave water bath, and cleaned by acetone; finally, the through-hole foam copper product which is provided with the hole formed by three-dimensional communicated space network, has the porosity of 50-81% and the average pore size of 0.2-4mm and is provided with microcosmic holes in a base body can be obtained. The obtained through-hole foam copper has controllable porosity and aperture, higher sintering quality and excellent energy absorbing performance.

The invention discloses a method for preparing a hydrophobic modified polyurethane associated thickener, which comprises the following steps: proceeding with vacuum-relieving dehydration of the screened polyethylene glycol in the fore-hole boiling flask; removing oxide by venting nitrogen after the acceptable dehydration; mixing by adding the accelerant; dropping indifferent solvent of diisocyanate in the proper temperature; generating polyurethane prepolymer by the polymerization reaction of high polymer free radical solution; proceeding with chain expansion polymerization by adding chain expansion agent; proceeding the hydrophobic modifying with the sealant; proceeding with the pressure reduction desolvation of the indifferent solvent and getting thickener when the polymerization reaction completes and the content of the free isocyanate is less than index range. The hydrophobic modified polyurethane associated thickener in benzenepropyl emulsion paint is provided with the considerable application function.

The invention relates to a butylphthalide synthesis method. The method comprises the steps that methyl 2-formyl benzoic acid is adopted as a starting material, THF is adopted as a solvent to react with an n-butyl magnesium chloride Grignard reagent, and acid regulation is performed to prepare a butylphthalide product. The invention further relates to a technology for preparing high-purity butylphthalide. The obtained crude butylphthalide product is subjected to hydrolysis treatment by an alkaline substance, acid regulation is performed to separate out solids, and filtering is performed to obtain a butylphthalide midbody; the acid regulation and alkali regulation processes are executed repeatedly, and finally ring closure and decompression desolvation are performed to obtain high-purity butylphthalide. According to the synthesis method, low-flash diethyl ether is prevented from being adopted as a solvent, the purification technology is easy to implement, the reagent can be purchased in bulk easily, column chromatography product purification and reduced pressure distillation under high temperature and high vacuum degree are not needed, and industrial enlarged production is easy.

A laser scattering based imaging technique is utilized in order to visualize the aerosol droplets in an inductively coupled plasma (ICP) torch from an aerosol source to the site of analytical measurements. The resulting snapshots provide key information about the spatial distribution of the aerosol introduced by direct and indirect injection devices: 1) a direct injection high efficiency nebulizer (DIHEN); 2) a large-bore DIHEN (LB-DIHEN); and 3) a PFA microflow nebulizer with a PFA Scott-type spray chamber. Moreover, particle image velocimetry (PUV) is used to study the in-situ behavior of the aerosol before interaction with, for example, plasma, while the individual surviving droplets are explored by particle tracking velocimetry (PTV). Further, the velocity distribution of the surviving droplets demonstrates the importance of the initial droplet velocities in complete desolvation of the aerosol for optimum analytical performance in ICP spectrometries. These new observations are important in the design of the next-generation direct injection devices for lower sample consumption, higher sensitivity, lower noise levels, suppressed matrix effects, and for developing smart spectrometers. For example, a controller can be provided to control the output of the aerosol source by controlling the configuration of the source or the gas flow rate via feedback information concerning the aerosol.

The invention discloses a method for producing krill oil, protein peptide powder and chitosan by full utilization of Antarctic krill powder. The method comprises the following steps: 1. extraction of krill oil: extracting the Antarctic krill powder by adopting an organic solvent, and carrying out low-temperature decompression desolvation, extraction and concentration on the extracting solution, wherein the contents of obtained krill oil phospholipid and astaxanthin are high; 2. preparation of protein peptide powder: carrying out compound enzymolysis on degreased shrimp meal to obtain an enzymolysis solution, and refining and then spray-drying the enzymolysis solution to obtain the protein peptide powder, wherein the peptide content of the obtained protein peptide powder is greater than or equal to 85%; and 3. preparation of chitosan: decalcifying the shrimp shell meal which is degreased by the organic solvent and is subjected to deproteinization by enzymolysis by adopting microorganism fermentation, further carrying out deproteinization, carrying out oxidative decoloration, and carrying out deacetylation to obtain chitosan and byproduct organic calcium. The method really realizes high-valued full utilization of the Antarctic krill powder, can be used for extracting nutritional ingredients in the Antarctic krill powder to the maximum extent so as to improve the resource utilization ratio, can avoid generation of waste residues, and can ensure the benefit maximization of an enterprise.

The instrument cold sprays a solution sample at a low temperature and desolvates the sample. Under this condition, a mass analysis is performed. The instrument comprises a needle pipe (8) through which the solution sample is passed, a sheath tube (24) formed coaxially with the needle pipe (8) and passing a temperature-controlled nebulizing gas therethrough, the above-described desolvation block (3), means for cooling the block (15), means for heating the block (4), and a temperature sensor (5) for detecting the temperature of the block (3). The block (3) has a passage for charged liquid droplets of the solution sample cold sprayed from the tip of the needle pipe (8), and acts to remove the solvent from the charged liquid droplets flowing through the passage. A coldspray mass spectrometer is offered which has a desolvation block whose temperature can be easily controlled. In the instrument, condensation of water and electrical leakage are prevented for a long time. The instrument can perform measurements stably and is easy to handle.

The invention provides a preparation method of difenoconazole technical material. 4-(4-chlorophenoxy)-2-chloroacetophenone performs cyclization reaction with 1,2-propylene glycol to generate cis / trans-3-chloro-4-(2,4-dimethyl-1,3-dioxolan-2-yl)phenyl-4'-chlorphenyl ether, then carries out bromination reaction with bromine to generate cis, / trans-3-chloro-4-(4-methyl-2-bromomethyl-1,3-dioxolan-2-yl)phenyl-4'-chlorphenyl ether, and carries out condensation reaction with 1, 2, 4-triazole potassium to prepare a crude product; a product is obtained after the crude product suffers from refining, desolvation, reduced pressure distillation , crystallization and centrifugation, bromine is added at twice while carrying out bromination reaction after cyclization reaction is over, bromine accounting for 3%-10% of total mass is added to reaction system for initiation reaction, remanent bromine is added after 10-30 minutes for reacting for 2-3 hours. Benzyl bromide accounting for 0.5%-5% of the quality of the crude product is added into the prepared crude product while refining the crude product, and heat is preserved for 1-3 hours at 200-300 DEG C.

A method of separating ions comprises applying a spot of a sample material to a target plate. The target plate is mounted in fluid communication with an ion inlet orifice of a FAIMS analyzer region and externally to the FAIMS analyzer region. Using a laser light source that is disposed external to the FAIMS analyzer region, the target plate is irradiated with light of a predetermined wavelength, the light of a predetermined wavelength being selected to affect the sample material applied to the target plate so as to produce ions of the sample material. The ions of the sample material are directed along an ion flow path between the target plate and FAIMS analyzer region, via the ion inlet orifice. A flow of a gas is directed counter-current to the ion flow path and passing through the target plate. The flow of gas through the target plate assists in desolvation of ions and directs neutral molecules away from the FAIMS analyzer region.

The invention discloses a preparing method for a vortioxetine hydrobromide alpha crystal form. The preparing method comprises the following step that sec-butyl alcohol is removed from a vortioxetine hydrobromide-sec-butyl alcohol complex to obtain the vortioxetine hydrobromide alpha crystal form. The method is low in desolvation temperature, and the prepared vortioxetine hydrobromide alpha crystal form is high in purity, suitable in particle size and suitable for industrial production.

The invention discloses a nanoparticle-loaded microsphere system for injection. Drugs are coated in nanoparticles, and the nanoparticles are coated in a microsphere, wherein the nanoparticles are made from material selected from one of albumin, chitosan and a polylactic acid-glycolic acid polymer, and the microsphere is made from either the chitosan or the polylactic acid-glycolic acid polymer. Furthermore, the invention provides a preparation method of the microsphere system, the nanoparticles are prepared through a desolvation and emulsification cross-linking method, a cross-linking method or a dual-emulsification method, and the prepared nanoparticles are further treated by the dual-emulsification method or a spray-drying method so as to obtain the microsphere. The nanoparticle-loaded microsphere system disclosed by the invention is free from a rejection reaction, and is applicable to parenteral administration; the microsphere system can adapt to natures of various drugs, which further enhances a controlled-release effect and controllability, the microsphere system can achieve a graded successive targeting effect by modifying two layers of materials inside and outside.

The invention discloses a preparation method of a porous CuAlMn shape memory alloy, which relates to the manufacturing of a porous shape memory alloy. The method comprises the following steps: with the sintering-desolvation technology, adding a trace fluoride powder additive into the CuAlMn shape memory alloy powder prepared by an atomization method, and performing ball milling to prepare a CuAlMn shape memory alloy powder raw material; mixing the raw material with NaCl particles without crystal water, and adding additive absolute ethyl alcohol into the mixture; placing the uniform mixture into a pressing mould, and pressurizing unidirectionally to obtain a green body; and performing sintering-desolvation and quenching to obtain the porous CuAlMn shape memory alloy product. The method has the advantages of simple process, low cost, high success rate, controllable product porosity and aperture and high sintering quality as well as good characteristics of damping and compression energy absorption, and is suitable to be used as a practical novel high-damping material.

The invention relates to the technical field of modern agriculture and especially relates to a method for extracting vegetable oil under a subcritical low temperature. The method comprises the following steps: S1) selecting seeds as raw materials, drying and putting the dried seeds into a grinder for grinding, wherein the grain size is not more than 40-mesh; S2) putting the seed grains into a subcritical extraction kettle, controlling a vacuum pump to control the vacuum degree in the subcritical extraction kettle and a separating kettle, injecting an extracting solvent butane till a sample is completely soaked, turning on a hot water heating valve for heating, and controlling the temperature and the extraction pressure in the extraction kettle and repeating extraction for 4 times; S3) after the ending of extraction, performing compressor desolvation on the mixture, turning on a valve at the lower end of the separating kettle after the ending of desolvation and collecting the crude seed oil; and S4) performing suction filtration on the prepared crude seed oil, thereby acquiring the refined seed oil. According to the method for extracting vegetable oil under the subcritical low temperature provided by the invention, the oil yield is increased, the resource waste is reduced, the energy consumption is lowered and the oil quality is promoted.

The invention discloses an ion mobility spectrometry employing an electrospray / corona discharge dual-mode ion source. Switching of two ionization modes is achieved; and the range of a detectable sample is expanded. An ion source is provided with a liquid-cooling component and a heating film component, which are used for rapidly setting the working temperature of a spray needle, so that different requirements of the two ionization modes on the temperature of the spray needle are met; the flow range of an injected sample is expanded; and the detection sensitivity is improved. A trumpet-shaped space is adopted by an electrospray / corona discharge region between the ion source and a drift tube, so that the atomization efficiency on the sample from low-temperature liquid to a gaseous state is improved; the desolvation effect of the sample is improved; and the sample residue is reduced. The drift tube is manufactured by a metal ceramic sealing technology, so that the connection strength is high; the insulativity and the air tightness are good; and installation together with other components is facilitated. The drift tube and a preheating gas circuit are arranged in a heating cylinder with uniform temperature as a whole, so that the phenomenon of migrating ion cluster diffusion caused by non-uniform temperature of blowback air in a migration area is reduced; and the detection resolution capability is improved.

This invention provides an interface of an air pressure ionic source set between an ionic source and a mass analyzer including a heated capillary, a capillary heater, a capillary temperature sensor, a RF multi-pole rod, a plane separation cone and a first level vacuum cavity and a method utilizing the interface including: ions generated by the air pressure ionic source enter into a heated capillary under the action of strong electric field and assistant gas flow and generate supersonic expansion at the outlet of the capillary so as to be led into a first level vacuum of a mass spectrometer to re-focus acted by the RF field of the RF multi-pole rod to be sent into a second level vacuum by the plane separation cone, which utilizes the ionic focusing action of the RF multi-pole rod to assemble ions led by the capillary to an ionic beam smaller than 0.5mm then induces it to a mass spectrometer having double desolvation action. This invention can integrate multiple kinds of atmosphere ionic sources with a mass analyzer to finish differential pumping.

The invention discloses a method for preparing multifunctional nano-carriers through a desolvation technology and a laminated assembling modification technology. Under a stirring condition, in water solution of protein, poor solvent ethanol is gradually dropped, so that the protein is gradually separated from the solution and precipitated with nano-particles; the nano-particle structure is washedby water after the nano-particle structure is stabilized by glutaric dialdehyde cross linking agent; a plurality of polymer electrolyte film layers are alternatively deposited on the surface of the nano-particle, and the polymer electrolyte of short-chain polyoxyethylene is deposited and grafted at the outmost layer so as to obtain the nano-particles modified by the polymer electrolyte; and a targeted molecule adapter is fixed at a carboxyl terminal of the polyoxyethylene so as to obtain the multifunctional nano-carriers. According to the invention, the preparation method is simple, the material resource is easily obtained, and the production efficiency is high; and the obtained nano-particles have excellent stability and good application prospect, and target cancer cells.

The invention is an extraction method of aliphatic polyester propylene carbonate with CO2 and epoxy compounds, especially for aliphatic polyester propylene carbonate desolvation. The procedure is as followings: put aliphatic polyester propylene carbonate with epoxypropane and relict catalyser in the autoclave. Add the desolvation agent while stiring for many times. Separate and dry to get polyester propylene carbonate, whose relict ash is lower than 1%. This invention is simple-manipualtion, lower cost and easy-industralization.

The purpose of the present invention is to enable highly-reliable bonding of bonding surfaces to be carried out such that the occurrence of uneven drying at the center and ends of the bonding surfaces, which occurs in-plane on a bonding layer in a desolvation process of a preliminary drying step, is reduced, thereby ensuring that the bonding surfaces do not detach even if repeatedly exposed to heat shock after bonding. This bonding material, which solves the aforementioned problem, is characterized by being covered by organic matter with a carbon number of six or less, comprising main silver particles, and covered by organic matter with a carbon number of six or less, comprising nano silver particles having an average primary particle size of 10 to 30 nm, and sub silver particles. The bonding material is further characterized by containing nano silver particles with an average primary diameter of 100 to 200 nm, two types of solvents with different boiling points, and a dispersant.

The invention provides a method for synthesizing lithium bis(fluorosulfonyl)imide. The synthetic method of the lithium bis(fluorosulfonyl)imide is characterized by comprising the following steps: (1) in a nitrogen atmosphere, sufficiently mixing bis(fluorosulfonyl)imide and an organic solvent, and putting a mixture into a reactor with a condenser; sequentially adding lithium fluoride and liquid-state hydrogen fluoride into the reactor and raising the temperature to react; (2) reducing the temperature of a reaction system, and decompressing and displacing by nitrogen to completely remove residual hydrogen fluoride gas, and filtering a reaction solution under the nitrogen atmosphere to remove insoluble matters, so as to obtain filtrate; (3) concentrating the filtrate by utilizing a high-vacuum decompression and desolvation method; (4) cooling a concentrated solution and adding a low-polarity solvent; recrystallizing at low temperature, and filtering and carrying out decompression and drying treatment at 40 DEG C to obtain the pure lithium bis(fluorosulfonyl)imide. The synthetic method has the advantages that used reagents are cheap and easy to obtain, a preparation process is simple, a reaction is rapid and complete, a few of byproducts are produced and are easy to remove, a post-treatment manner is simple and convenient, a product has high purity and the synthetic method is very suitable for industrial production.