Ion mobility spectrometry employing electrospray/corona discharge dual-mode ion source

An ion mobility and electrospray ionization technology, applied in the field of ion mobility spectrometer, can solve the problems of difficulty in the detection of non-polar substances, affecting the repeatability of detection, unstable sample volume, etc. Ionization effect, the effect of extending the working temperature

Active Publication Date: 2015-12-23
INST OF ELECTRONICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the high flow rate of the pumping gas, the supplementary gas will be sucked in from the external environment of the ion source to introduce interfering substances. At the same time, the large liquid droplets pumped out also contain a large amount of sample s...

Method used

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  • Ion mobility spectrometry employing electrospray/corona discharge dual-mode ion source
  • Ion mobility spectrometry employing electrospray/corona discharge dual-mode ion source
  • Ion mobility spectrometry employing electrospray/corona discharge dual-mode ion source

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Embodiment 1

[0044] figure 2 It is the ion mobility spectrum obtained when the device of the present invention adopts the electrospray ionization mode to detect the sample solution of the hypoglycemic drugs metformin and phenformin at a concentration of 5 mg / L. The drift tube temperature is 200°C, the backflush gas flow rate is 1L / min, and the electrospray voltage is 2300V. The sample solution solvent was 90% methanol solution, and the electrospray flow rate was 10 μL / min. The ion signal peaks of metformin and phenformin were obtained at 11.25 ms and 14.36 ms, respectively. The measurement detection limit is 0.1mg / L and 0.2mg / L respectively, the linear range of ion peak intensity and concentration is 0.2mg / L~5mg / L, and the resolution (ratio of drift time to ion peak FWHM time) is greater than 50 .

Embodiment 2

[0046] image 3 It is the ion mobility spectrum obtained when the device of the present invention adopts the corona discharge ionization mode to detect the 2mg / L concentration malathion sample solution. The drift tube temperature is 200°C, the blowback gas flow is 1L / min, and the corona discharge voltage is 3500V. The sample solution solvent was chromatographically pure methanol, and the solution flow rate in the needle was 10 μL / min, and the ion signal peak of malathion was obtained at 17.56 ms. The detection limit of measurement is 0.25mg / L, and the linear range of ion peak amplitude and concentration is 0.25mg / L~5mg / L.

Embodiment 3

[0048] Figure 4 It is the three-dimensional atlas obtained when the device of the present invention adopts the electrospray ionization mode and is used in conjunction with high-performance liquid chromatography (HPLC) to detect four kinds of antibiotic mixed solutions, wherein tetrabutylammonium bromide is a calibration reference substance, and the antibiotic is perfluorinated Floxacin, penicillin, ampicillin and amoxicillin, the concentration of each sample is 5mg / L. The abscissa of the graph is the retention time of the chromatographic column, and the ordinate is the drift time of the drift tube. The temperature of the drift tube is 200°C, and the flow rate of backflush gas is 1L / min. The liquid chromatography column is a C18 column, the mobile phase is 80% methanol solution, the flow rate is 1ml / min, and 10 μL / min is separated through a three-way splitter and introduced into IMS. Inject the sample through the six-port injection valve, and the constant volume tube is 20 μ...

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Abstract

The invention discloses an ion mobility spectrometry employing an electrospray/corona discharge dual-mode ion source. Switching of two ionization modes is achieved; and the range of a detectable sample is expanded. An ion source is provided with a liquid-cooling component and a heating film component, which are used for rapidly setting the working temperature of a spray needle, so that different requirements of the two ionization modes on the temperature of the spray needle are met; the flow range of an injected sample is expanded; and the detection sensitivity is improved. A trumpet-shaped space is adopted by an electrospray/corona discharge region between the ion source and a drift tube, so that the atomization efficiency on the sample from low-temperature liquid to a gaseous state is improved; the desolvation effect of the sample is improved; and the sample residue is reduced. The drift tube is manufactured by a metal ceramic sealing technology, so that the connection strength is high; the insulativity and the air tightness are good; and installation together with other components is facilitated. The drift tube and a preheating gas circuit are arranged in a heating cylinder with uniform temperature as a whole, so that the phenomenon of migrating ion cluster diffusion caused by non-uniform temperature of blowback air in a migration area is reduced; and the detection resolution capability is improved.

Description

technical field [0001] The invention relates to the technical field of ion detection, more particularly to an ion mobility spectrometer (IonMobility Spectrometry, IMS) that adopts an electrospray (Electrospray Ionization Source, ESI) / corona discharge (Coronadischarge, CD) dual-mode ion source, which can improve ion mobility. Detection sensitivity and resolving power of mobility spectroscopy. Background technique [0002] Ion mobility spectrometry (IMS) is an analytical technique for characterizing substances based on differences in the mobility of ions in the gas phase in an electric field. Compared with traditional detection techniques such as chromatography and mass spectrometry, it has the advantages of simple equipment structure, working under normal pressure without vacuum system, high detection sensitivity, fast analysis speed, easy miniaturization and portability, etc. Among them, the ion source is an important part of IMS, which plays a key role in the ionization pr...

Claims

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Application Information

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IPC IPC(8): H01J49/10G01N27/62G01N27/622G01N27/626
Inventor 贾建高晓光何秀丽李建平
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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