2 results about "Phenformin" patented technology

The application discloses a nano drug based on nitrogen-doped selenized carbon dots and a preparation method and application thereof, and belongs to the technical field of biological medicines, wherein the preparation method of the nano drug comprises the following steps: placing an amino acid compound and a small molecule drug in a solvent to mix, adjusting the pH value to be alkaline, then performing a heating reaction to obtain a reaction solution; the amino acid compound is one or more of L-selenocystine, L-selenocysteine and L-selenomethionine; the small molecule drug is metformin hydrochloride or phenformin; and the nano drug is obtained by separating and purifying from the reaction solution. The nano drug can significantly relieve cell oxidative damage induced by hydrogen peroxide, can effectively remove ROS excessively accumulated in a damage site, and can inhibit the progress of secondary damage. In addition, the nano drug can regulate four key signal paths of antioxidation, anti-inflammation, anti-apoptosis and axon regeneration and myelination, and can synergistically promote the nerve repair process after spinal cord injury.

The application discloses a dual-unit fluorescent sensor array for detecting oral anti-diabetic drugs and application thereof, and relates to a supramolecular fluorescent sensor array which comprises a PAL@Q[8] sensing unit and a bpep-Am@Q[8] sensing unit, wherein the PAL@Q[8] sensing unit is composed of palmatine and Q[8], and the bpep-Am@Q[8] sensing unit is composed of a derivative of 1,4-bis[2-(4-pyridyl)vinyl]benzene and Q[8]. The dual-unit fluorescent sensor array can be used for qualitative detection and quantitative detection of metformin, phenformin, buformin hydrochloride, rosiglitazone and sitagliptin in serum or urine, and the method provides a simple and reliable analysis tool for rapid screening of oral hypoglycemic drugs, clinical blood drug concentration monitoring and identification of hypoglycemia causes, so as to realize on-site rapid visual analysis of oral hypoglycemic drugs.