563results about "Aldehyde active ingredients" patented technology

The invention discloses a Pickering emulsion with cinnamyl aldehyde as an oil phase and a preparation method of the Pickering emulsion. The Pickering emulsion is prepared by the following steps: carrying out a cross-linking reaction on anions released by sodium tripolyphosphate and protonated cations of chitosan to prepare chitosan nanoparticles as a water phase, and then taking cinnamyl aldehyde as an oil phase. The Pickering emulsion delivery system disclosed by the invention can effectively release cinnamyl aldehyde, shows the remarkable antibacterial property of cinnamyl aldehyde on a wound surface, promotes wound surface healing, and shows good treatment potential.

The invention provides a cinnamyl aldehyde drug-loaded self-microemulsion as well as a preparation method and application thereof, and belongs to the technical field of biological pharmacy. The cinnamyl aldehyde drug-loaded self-microemulsion disclosed by the invention is prepared from the following raw materials in parts by weight: 0.5 to 5.5 parts of cinnamyl aldehyde, 0 to 5.5 parts of oil phase, 0.5 to 5.5 parts of emulsifier and 0.01 to 0.045 part of insoluble drug. By adopting the self-microemulsion drug delivery system, the drug effect of the cinnamyl aldehyde and the combination of the cinnamyl aldehyde and other traditional Chinese medicine components is improved, the drug loading capacity is high, dispersion is easy, the stability is high, the drug effect is remarkable after the cinnamyl aldehyde and other traditional Chinese medicine components are combined, and the curative effect is good. The traditional Chinese medicine composition has an improvement effect on hepatic fibrosis, has a remarkable treatment effect on non-alcoholic steatohepatitis, and has certain application and development values.

The invention belongs to the technical field of medicines, cosmetics and scalp care, and particularly relates to application of coniferaldehydes and derivatives or salts of the coniferaldehydes to preparation of medicines and cosmetics for promoting hair regeneration and treating chemotherapy-induced alopecia (CIA, CIA) and other types of alopecia, in particular to application of the coniferaldehydes and the derivatives or salts of the coniferaldehydes to preparation of the medicines and the cosmetics. Experimental results show that coniferyl aldehyde can promote hair regeneration of mice, accelerate hair growth of the mice and effectively relieve alopecia symptoms of the mice after chemotherapy, and the effect of coniferyl aldehyde is better than that of minoxidil. According to the application, coniferyl aldehyde or a composition thereof is given to a subject, so that the vigor of hair follicles is remarkably enhanced, the stationary period of the hair follicles is shortened, and the hair loss process is inhibited. The coniferyl aldehyde provided by the invention has the industrial application advantages of reliable biological safety, controllable preparation cost and high raw material accessibility, can be obtained by a plant extraction or chemical synthesis method, is suitable for an external solution, gel or a scalp care preparation, and provides a natural, safe and effective solution for alopecia patients.

The invention belongs to the technical field of external medicine compositions, and particularly relates to microsphere type antibacterial gel as well as a preparation method and application thereof. The preparation comprises three parts, namely dextran microspheres wrapped by polyethylene glycol, a mixed antibacterial component and a carbomer mixed solution. The mixed antibacterial component is prepared from thymol, chlorhexidine acetate, cinnamyl aldehyde, citral, gallic acid and nano silver. Glucan is prepared into microspheres by utilizing a micro-fluidic chip technology, antibacterial components are wrapped in the microspheres, then the microspheres are compounded into the microsphere type antibacterial gel, and the gel not only shows excellent antibacterial performance and strong adhesive capacity, but also has a remarkable wound repair promoting effect; the microsphere structure can wrap and mix the antibacterial components and play a role in controlled release of the antibacterial components, so that a novel solution is provided for the medical field of antibacterial gel.

Disclosed herein are compositions of matter suitable for use in foods, feeds, pharmaceuticals and cosmetic care products, the compositions of matter comprising a retinoid component and fermentation residues thereof. In embodiments, the retinoid component is present in a weight ratio relative to the fermentation residue of 4: 1 or greater, where the retinoid contains cis-isomer and trans-isomer, where the cis-isomer is present in an amount of less than 3% by weight relative to the entire isomer mixture. Preferably, the composition is bio-based. Also described are biotechnological methods for producing the compositions otherwise described, as well as additional methods for processing such compositions into more stable, more commercially acceptable forms. Finally, foods, feeds, pharmaceuticals, and cosmetic care products incorporating the compositions described herein are also disclosed.

The invention relates to an o / w type high-content composite essential oil nanoemulsion and a preparation method and application thereof.The median particle size of the composite essential oil nanoemulsion is not larger than 45 nm, and the composite essential oil nanoemulsion comprises plant essential oil, polyethylene glycol glycerol ricinoleate with the HLB value being 10-14, a cosolvent, water, vitamin E acetate and ethylene diamine tetraacetic acid disodium salt. The plant essential oil is selected from two or more of carvacrol, cinnamyl aldehyde, capsicum oleoresin and thymol. The compound essential oil nanoemulsion solves the key technical problem of high-content load compound nanoemulsion of various plant essential oils, is beneficial to exerting the synergistic effect of different essential oils, and reduces the addition amount of the essential oils while achieving the same physiological function. Besides, the particle size of the composite essential oil nanoemulsion reaches the nanoscale, the composite essential oil nanoemulsion can form homogeneous-phase clear liquid, can be quickly diffused in a waterline or a water environment, is more beneficial to absorption, has the advantages of good stability and long storage life, and is more competitive in practical application.

The present invention relates to a composition comprising (i) an extract of Crocus sativus comprising at least safranal, and (ii) an extract of Cannabis sativa comprising cannabidiol (CBD) and uses thereof as a pharmaceutical product, a food supplement, a nutritional product, a cosmetic product, or a liquid suitable for electronic cigarettes.

The invention belongs to the technical field of biological materials, and particularly relates to a conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity and a preparation method of the conductive hydrogel microneedle patch. The preparation method comprises the following steps: firstly, loading plant essential oil with antibacterial and anti-inflammatory activity on mesoporous polypyrrole nanoparticles to prepare drug-loaded nanoparticles, then preparing a pre-hydrogel mixture containing the drug-loaded nanoparticles, and then filling the mixture into a PDMS microneedle mold to obtain the conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity. The prepared microneedle patch not only has excellent antibacterial and anti-inflammatory activity and a conductive function, but also has the characteristics of a microneedle and hydrogel, and can deliver a drug to a skin cuticle or a lower layer of a bacterial biofilm, so that the bioavailability of transdermal drug delivery of the drug is greatly improved. Besides, the microneedle patch is swelled after absorbing tissue exudate, is adhered to the surface of skin or other mucous membranes to continuously play antibacterial and anti-inflammatory roles and conductive functions, and provides wet healing conditions, so that high-quality healing of skin wounds is accelerated.

The invention discloses a nerve cell senescence resisting medicine containing p-hydroxybenzaldehyde and application thereof.The p-hydroxybenzaldehyde is adopted as the only active substance, and the p-hydroxybenzaldehyde can reduce accumulation of DNA damage in cells, reduce activity of beta-galactosidase in the cells and slow down reduction of cell metabolic capacity, so that the nerve cell senescence resisting medicine is obtained. Therefore, the senescence of nerve cells is effectively slowed down, the cognitive function is improved, and a potential treatment effect is achieved in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

The invention discloses an anti-tumor drug delivery system based on click chemistry and a hollow covalent organic framework material as well as a preparation method and application of the anti-tumor drug delivery system, and belongs to the technical field of novel biomedical materials. The anti-tumor drug delivery system based on the click chemistry and the hollow covalent organic framework material comprises a bowl-shaped hollow covalent organic framework material carrier, and a click chemistry prodrug 1 and a click chemistry prodrug 2 which are loaded in the bowl-shaped hollow covalent organic framework material carrier, the click chemistry prodrug 1 is a compound containing an aldehyde group, and the click chemistry prodrug 2 is a compound containing an amino group. By combining the high-specificity reaction of click chemistry with the excellent drug loading performance of HCOF, accurate drug release can be realized in a tumor-specific microenvironment, the toxicity of normal cells can be remarkably reduced, the treatment effect is improved, and a wide clinical application prospect is shown.

Methods of treating, suppressing, or reducing the severity of a liver cancer in a subject are described herein. The disclosed methods involve administering a therapeutically effective amount of a composition including safranal or its pharmaceutically acceptable pro-drug, and a pharmaceutically acceptable carrier to the subject. The disclosed methods may be used to treat, suppress, or reduce the severity of various liver cancers, including hepatocellular carcinoma (HCC), fibrolamellar HCC, cholangiocarcinoma, angiosarcoma, a metastatic liver cancer, and combinations thereof.

The invention discloses oral brain-targeted nanoemulsion as well as a preparation method and application thereof, and belongs to the field of biological medicine preparations. Drug molecules and a stabilizer are dispersed in oil phase molecules, and then a surfactant and water are added to prepare the nano-emulsion. Drug molecules are dispersed in oil-phase molecules and then form an oil-in-water nanoemulsion with water, so that the problems of poor stability and poor water solubility of current drug molecules are solved, the oral bioavailability of the drug is improved, fusion of different drug molecules of multiple targets is realized, the drug loading capacity of the drug molecules can be effectively ensured, and the bioavailability of the drug is improved. In addition, the drug can pass through an intestinal barrier and a blood brain barrier to be successfully delivered to a brain region to realize multi-target treatment, so that efficient treatment of multi-target brain diseases such as neurodegenerative diseases and central nervous system tumors is realized.

The invention provides a compound as shown in a formula I, or pharmaceutically acceptable salt or ester, prodrug, optical isomer, stereoisomer or solvate thereof. The compound disclosed by the invention can be used for preparing medicines for preventing or treating pain and related diseases thereof, so that a brand new material basis is laid for developing the pain and the related diseases thereof. # imgabs0 #

The invention provides application of coniferyl aldehyde in eye protection products, and belongs to the technical field of eye health. The coniferyl aldehyde is found to have an eye protection effect for the first time, and particularly has a protection effect on retina light injury. Cell model and animal model experiments prove that coniferyl aldehyde has a protective effect on eye cell apoptosis, retina light injury and the like, so that coniferyl aldehyde can be applied to development and application of drugs for treating retina light injury diseases and functional products for relieving visual fatigue and the like.

The invention provides a difluoromethoxy phenyl compound as shown in formula (I), or pharmaceutically acceptable salts, solvates, hydrates, prodrugs, stereoisomers, polymorphs, eutectic crystals or isotope markers of the difluoromethoxy phenyl compound, and application of the difluoromethoxy phenyl compound and the pharmaceutically acceptable salts, solvates, hydrates, prodrugs, stereoisomers, polymorphs, eutectic crystals or isotope markers in medicine, and the difluoromethoxy phenyl compound and the pharmaceutically acceptable salts, solvates, hydrates, prodrugs, stereoisomers, polymorphs, eutectic crystals or isotope markers can be used for preparing anti-tumor drugs # imgabs0 #.

The invention relates to an antibacterial hydrogel, which is a gel formed by taking chitosan quaternary ammonium salt as a component and contains protocatechualdehyde. It is verified that the antibacterial hydrogel is good in biocompatibility and high in safety, has the capabilities of resisting bacteria, resisting generation of bacterial biofilms, resisting inflammation, resisting oxidation and the like and immunoregulatory activity, can play a good acute otitis media treatment effect in a local administration mode, is low in drug resistance, facilitates reduction of abuse of antibiotics, and has a good application prospect. Infection and recurrence are effectively prevented, and a novel, safe and ideal treatment method is provided for clinical decision-making of acute otitis media patients. The gel is prepared into an ear drop dosage form, does not flow out after being dropped into the ear canal, and is convenient to take.

The invention provides a composition and a method for sow simultaneous delivery and application of the composition and the method, and particularly discloses a composition and a method for shortening the delivery process and improving the live piglet rate according to a sow simultaneous delivery scheme applying vitamin B6, mifepristone, cloprostenol sodium and carbetocin. According to the composition, aiming at the problem that the sow production efficiency is influenced by the reduction of the live piglet rate caused by the simultaneous delivery of sows, the vitamin B6 and the mifepristone are combined on the basis of the delivery drugs cloprostenol sodium and carbetocin, so that a set of new simultaneous delivery scheme is formed; according to the method, the delivery process of the sows is shortened, the live piglet rate of the sows is increased, the method is a method for improving the same-period delivery effect of the sows in batches, and great value is provided for improving the PSY of the sows and promoting batch management of the sows.

The invention discloses a feed additive for preventing broiler necrotic enteritis, a preparation method and application, and relates to the technical field of feed. Comprising the following raw materials in parts by weight: 15-30 parts of plant essential oil, 40-60 parts of deoxycholic acid, 10-20 parts of vitamin D310, 3-8 parts of protein zinc, 2-6 parts of saccharomyces cerevisiae and 1-5 parts of zeolite powder. The feed additive provided by the invention is clear in component, stable in property, convenient to operate and control, easy to realize industrial production, and convenient to popularize and apply. By adopting the feed additive provided by the invention, the integrity of the intestinal epithelial barrier can be improved, the intestinal flora structure can be improved, the immunity of the organism can be improved, and necrotic enteritis of broilers can be effectively prevented.

The invention belongs to the technical field of external pharmaceutical compositions, and particularly relates to a temperature phase change microsphere antibacterial gel and a preparation method thereof. The gel is composed of three core components: temperature phase change microspheres, a composite antibacterial component and a carbomer matrix solution. The antibacterial component comprises carvacrol, oregano oil, cinnamyl aldehyde, citral, gallic acid and nano-silver, and aims to realize a broad-spectrum and efficient antibacterial effect. Hydrogel is prepared into microspheres (the phase change temperature is 33 DEG C) by utilizing a micro-fluidic chip technology, antibacterial components are wrapped in the microspheres, and then the temperature phase change microsphere antibacterial gel is compounded. When the gel is daily stored, the microspheres can realize long-time activity maintenance of antibacterial components and play a role in protecting the active components. When the gel is smeared on the skin surface, the human body temperature (36-37 DEG C) is higher than the phase change temperature (33 DEG C), the gel microspheres are subjected to phase change, sustained and controlled release of antibacterial components is achieved, and the better antibacterial effect is achieved.

The invention provides a bacteriostatic agent aiming at yersinia enterocolitica and application, the bacteriostatic agent comprises a compound solution of lipoic acid and protocatechualdehyde, and when the lipoic acid and the protocatechualdehyde act synergistically, the minimum inhibitory concentrations to the yersinia enterocolitica are 0.625 mg / mL and 0.3125 mg / mL respectively. The yersinia enterocolitica biofilm is inhibited and / or removed through the lipoic acid and protocatechuic aldehyde compound liquid, and the problem that drugs for treating the yersinia enterocolitica infection are prone to drug resistance is solved.

The invention provides an application of protocatechualdehyde in preparation of an external medicine for preventing or / and treating psoriasis. The medicine is used for preventing or / and treating psoriasis, the medicine effect is clear, in-vitro cell experiments prove that the expression level of inflammatory factors such as IL-1alpha and CXCL9 is effectively reduced by inhibiting the phosphorylation of STAT3, the important value of the medicine in scientific research and clinical application is shown, and a new medicine selection is provided for clinic.

Compositions contain an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The amount of cinnamaldehyde is supplemented by zinc, and the combination is effective to promote a swallowing reflex. The composition containing the combination of cinnamaldehyde and zinc can be used in a method to treat dysphagia and / or prevent aspiration pneumonia from dysphagia. In an embodiment, the composition containing cinnamaldehyde is administered to a human. The composition containing cinnamaldehyde may be a medicament, a food product or a supplement to a food product.

Compositions and methods are disclosed herein for inducing (up-regulating) the expression and / or activity of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and / or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH. Additionally, methods for preparing a stable liposomal containing solution are described.

The present disclosure relates to a pharmaceutical composition comprising a combination of anticancer agents, capable of creating a synergistic effect when co-administer in the treatment of cancer, and more specifically, the present invention suggests anticancer agenst capable of creating a synergistic effect when co-administered with gossypol and phenformin. The anticancer agents selected as said anticancer agents in the present disclosure are sorafenib, vemurafenib, irinotecan, cisplatin, paclitaxel, and doxorubicin, and each of the aforementioned anticancer agent, when co-administered as a triple-drug combination with gossypol and phenformin can provide a significant synergistic effect in terms of the effect of suppressing the proliferation of cancer and killing cancer cell, compared to each mono-drug treatment group and a dual-drug treatment group of gossypol+phenformin.

The present disclosure relates to methods for evaluating the ability of test fragrance ingredients or test fragrance compositions to improve an invigorated state in a human subject, and for creating fragrance compositions that have a positive revitalizing effect on a human subject, as well as fragrance compositions for improving an invigorated state in a human subject, consumer products comprising such fragrance compositions, and methods for improving an invigorated state in a human subject.

The invention provides an active oxygen and active nitrogen cascade anti-tumor nano-drug aiming at tumor treatment obstacles of insufficient hydrogen peroxide and ultra-short service life of nitric oxide in tumors, and the combined effect of plant aldehyde and natural amino acid is taken as the core content of anti-tumor treatment. Nanoparticles are used as a carrier, the carrier is coated with a biocompatible material, plant aldehyde is loaded or grafted, and natural amino acid is packaged. In a tumor acidic environment, the plant aldehyde releases hydroxyl radicals to realize active oxygen therapy. When hydroxyl radicals are generated, hydrogen peroxide can be slowly released by the plant aldehyde, then natural amino acid is triggered to be converted into nitric oxide, and active nitrogen therapy is achieved. The controlled release of the plant aldehyde enables the release of the nitric oxide to be controllable, and the realization of space-time release of the active oxygen and the nitric oxide is realized, so that the complementarity of the active oxygen and the nitric oxide in pharmacokinetics is fully utilized, and a strong anti-tumor effect is generated. The preparation method is easy to operate, the raw materials are easy to obtain, and the prepared nano-particles loaded with the plant aldehyde and the natural amino acid have good particle dispersity, chemical stability and biocompatibility and are an ideal chemical-gas therapy-ferroptosis cascade cancer treatment reagent.

Described herein are compositions for delaying onset or delaying progression of frailty, reversing aging phenotype, extending healthspan, compressing morbidity, increasing lifespan and reducing formation of senescent cells.

The invention provides a composition for inhibiting tumor growth and a preparation method thereof, and belongs to the technical field of medicines. After selenium is loaded, folic acid is coupled, and folic acid-selenium polysaccharide nanoparticles are prepared; notoginsenoside, curcumin, alizarin and hairyvein agrimony phenolic acid are embedded in pH-sensitive lipidosome, and the pH-sensitive lipidosome is uniformly mixed with folic acid-selenium polysaccharide nanoparticles and semicarbazone compounds to prepare the composition for inhibiting tumor growth. The composition for inhibiting tumor growth prepared by the invention has a relatively good anti-tumor effect, can release active components in a targeted manner at a tumor part, can reverse drug resistance, reduce the dosage of chemical drugs, reduce toxicity and improve patient compliance, is high in bioavailability, and has a wide application prospect.

The invention discloses a diisoprene derivative as shown in a structural general formula (I) and a structural general formula (II), or pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, the diisoprene derivative has the activity of regulating the expression of a low-density lipoprotein receptor (LDLR), and can inhibit tumor cell proliferation, control inflammatory factor release, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation and inhibit tumor cell proliferation. The accumulation of retinal lipofuscin is reduced, macular degeneration is improved, and retinal injury is relieved. The diisoprene derivative can be used for treating diseases related to abnormal lipid metabolism, such as cardiovascular diseases, metabolic diseases, cancer, inflammation, retinal diseases and / or other diseases. # imgabs0 #