344results about "Aldehyde active ingredients" patented technology

The invention belongs to the technical field of medicines, cosmetics and scalp care, and particularly relates to application of coniferaldehydes and derivatives or salts of the coniferaldehydes to preparation of medicines and cosmetics for promoting hair regeneration and treating chemotherapy-induced alopecia (CIA, CIA) and other types of alopecia, in particular to application of the coniferaldehydes and the derivatives or salts of the coniferaldehydes to preparation of the medicines and the cosmetics. Experimental results show that coniferyl aldehyde can promote hair regeneration of mice, accelerate hair growth of the mice and effectively relieve alopecia symptoms of the mice after chemotherapy, and the effect of coniferyl aldehyde is better than that of minoxidil. According to the application, coniferyl aldehyde or a composition thereof is given to a subject, so that the vigor of hair follicles is remarkably enhanced, the stationary period of the hair follicles is shortened, and the hair loss process is inhibited. The coniferyl aldehyde provided by the invention has the industrial application advantages of reliable biological safety, controllable preparation cost and high raw material accessibility, can be obtained by a plant extraction or chemical synthesis method, is suitable for an external solution, gel or a scalp care preparation, and provides a natural, safe and effective solution for alopecia patients.

Disclosed herein are compositions of matter suitable for use in foods, feeds, pharmaceuticals and cosmetic care products, the compositions of matter comprising a retinoid component and fermentation residues thereof. In embodiments, the retinoid component is present in a weight ratio relative to the fermentation residue of 4: 1 or greater, where the retinoid contains cis-isomer and trans-isomer, where the cis-isomer is present in an amount of less than 3% by weight relative to the entire isomer mixture. Preferably, the composition is bio-based. Also described are biotechnological methods for producing the compositions otherwise described, as well as additional methods for processing such compositions into more stable, more commercially acceptable forms. Finally, foods, feeds, pharmaceuticals, and cosmetic care products incorporating the compositions described herein are also disclosed.

The invention relates to an o / w type high-content composite essential oil nanoemulsion and a preparation method and application thereof.The median particle size of the composite essential oil nanoemulsion is not larger than 45 nm, and the composite essential oil nanoemulsion comprises plant essential oil, polyethylene glycol glycerol ricinoleate with the HLB value being 10-14, a cosolvent, water, vitamin E acetate and ethylene diamine tetraacetic acid disodium salt. The plant essential oil is selected from two or more of carvacrol, cinnamyl aldehyde, capsicum oleoresin and thymol. The compound essential oil nanoemulsion solves the key technical problem of high-content load compound nanoemulsion of various plant essential oils, is beneficial to exerting the synergistic effect of different essential oils, and reduces the addition amount of the essential oils while achieving the same physiological function. Besides, the particle size of the composite essential oil nanoemulsion reaches the nanoscale, the composite essential oil nanoemulsion can form homogeneous-phase clear liquid, can be quickly diffused in a waterline or a water environment, is more beneficial to absorption, has the advantages of good stability and long storage life, and is more competitive in practical application.

The invention discloses a nerve cell senescence resisting medicine containing p-hydroxybenzaldehyde and application thereof.The p-hydroxybenzaldehyde is adopted as the only active substance, and the p-hydroxybenzaldehyde can reduce accumulation of DNA damage in cells, reduce activity of beta-galactosidase in the cells and slow down reduction of cell metabolic capacity, so that the nerve cell senescence resisting medicine is obtained. Therefore, the senescence of nerve cells is effectively slowed down, the cognitive function is improved, and a potential treatment effect is achieved in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

The invention discloses an anti-tumor drug delivery system based on click chemistry and a hollow covalent organic framework material as well as a preparation method and application of the anti-tumor drug delivery system, and belongs to the technical field of novel biomedical materials. The anti-tumor drug delivery system based on the click chemistry and the hollow covalent organic framework material comprises a bowl-shaped hollow covalent organic framework material carrier, and a click chemistry prodrug 1 and a click chemistry prodrug 2 which are loaded in the bowl-shaped hollow covalent organic framework material carrier, the click chemistry prodrug 1 is a compound containing an aldehyde group, and the click chemistry prodrug 2 is a compound containing an amino group. By combining the high-specificity reaction of click chemistry with the excellent drug loading performance of HCOF, accurate drug release can be realized in a tumor-specific microenvironment, the toxicity of normal cells can be remarkably reduced, the treatment effect is improved, and a wide clinical application prospect is shown.

Methods of treating, suppressing, or reducing the severity of a liver cancer in a subject are described herein. The disclosed methods involve administering a therapeutically effective amount of a composition including safranal or its pharmaceutically acceptable pro-drug, and a pharmaceutically acceptable carrier to the subject. The disclosed methods may be used to treat, suppress, or reduce the severity of various liver cancers, including hepatocellular carcinoma (HCC), fibrolamellar HCC, cholangiocarcinoma, angiosarcoma, a metastatic liver cancer, and combinations thereof.

The invention provides application of coniferyl aldehyde in eye protection products, and belongs to the technical field of eye health. The coniferyl aldehyde is found to have an eye protection effect for the first time, and particularly has a protection effect on retina light injury. Cell model and animal model experiments prove that coniferyl aldehyde has a protective effect on eye cell apoptosis, retina light injury and the like, so that coniferyl aldehyde can be applied to development and application of drugs for treating retina light injury diseases and functional products for relieving visual fatigue and the like.

The invention provides a bacteriostatic agent aiming at yersinia enterocolitica and application, the bacteriostatic agent comprises a compound solution of lipoic acid and protocatechualdehyde, and when the lipoic acid and the protocatechualdehyde act synergistically, the minimum inhibitory concentrations to the yersinia enterocolitica are 0.625 mg / mL and 0.3125 mg / mL respectively. The yersinia enterocolitica biofilm is inhibited and / or removed through the lipoic acid and protocatechuic aldehyde compound liquid, and the problem that drugs for treating the yersinia enterocolitica infection are prone to drug resistance is solved.

The invention provides a composition for inhibiting tumor growth and a preparation method thereof, and belongs to the technical field of medicines. After selenium is loaded, folic acid is coupled, and folic acid-selenium polysaccharide nanoparticles are prepared; notoginsenoside, curcumin, alizarin and hairyvein agrimony phenolic acid are embedded in pH-sensitive lipidosome, and the pH-sensitive lipidosome is uniformly mixed with folic acid-selenium polysaccharide nanoparticles and semicarbazone compounds to prepare the composition for inhibiting tumor growth. The composition for inhibiting tumor growth prepared by the invention has a relatively good anti-tumor effect, can release active components in a targeted manner at a tumor part, can reverse drug resistance, reduce the dosage of chemical drugs, reduce toxicity and improve patient compliance, is high in bioavailability, and has a wide application prospect.

The invention discloses a diisoprene derivative as shown in a structural general formula (I) and a structural general formula (II), or pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, the diisoprene derivative has the activity of regulating the expression of a low-density lipoprotein receptor (LDLR), and can inhibit tumor cell proliferation, control inflammatory factor release, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation and inhibit tumor cell proliferation. The accumulation of retinal lipofuscin is reduced, macular degeneration is improved, and retinal injury is relieved. The diisoprene derivative can be used for treating diseases related to abnormal lipid metabolism, such as cardiovascular diseases, metabolic diseases, cancer, inflammation, retinal diseases and / or other diseases. # imgabs0 #

The invention relates to the technical field of plant extraction, and provides a plurality of phenolic compounds in senecio scandens, and a preparation method and application thereof. The method comprises the following steps: crushing senecio scandens, adding ethyl acetate, and performing ultrasonic heating, stirring and extracting to obtain an extracting solution; carrying out rotary evaporation and vacuum concentration on the extracting solution to obtain a crude extract; dissolving the crude extract by using absolute ethyl alcohol through ultrasonic heating, carrying out gradient elution through a macroporous adsorption resin chromatographic column, and collecting an ethanol water eluent; and concentrating the ethanol water eluent under reduced pressure, stirring with a reverse-phase filler, loading with a dry method, packing with a wet method, and sequentially performing isocratic elution with a reverse-phase chromatographic column and purification with a gel column. The dissolution efficiency of phenolic compounds in senecio scandens is improved through ultrasonic and mild heating, the problems that components are degraded due to high temperature in traditional reflux extraction and time and solvent are consumed in dipping extraction are solved, and target component residues are reduced; and then through gradient elution of a chromatographic separation column, isocratic elution of a reversed-phase chromatographic column and purification of a gel column, the problem that phenols are similar in structure and easy to co-elute is accurately solved.

The present disclosure relates to compositions for improving gut health and / or milk production in ruminants, comprising: at least one organic acid chosen from sorbic acid, fumaric acid, malic acid, lactic acid, citric acid, formic acid, salts thereof and mixtures thereof; at least one essential oil chosen from thymol, eugenol, vanillin, thyme oil, carvacrol, cinnamaldehyde, clove leaf essential oil, and mixtures thereof; at least one bacterial fermentation product chosen from bacterial fermentation products of a Bacillus fermentation product, a Streptomyces fermentation product, an Aspergillus fermentation product, a Streptococcus fermentation product, a Paenibacillus fermentation product and mixtures thereof; at least one plant extract chosen from a saponin, a Yucca extract, a Quillaja extract and mixtures thereof; and at least one controlled release matrix.

The invention belongs to the technical field of natural pharmaceutical chemistry and medical application, and discloses a quinolone antibiotic synergist and application thereof in preparation of a medicine for treating bacterial infection. The structural formula of the quinolone antibiotic synergist is shown in the specification. The quinolone antibiotic synergist can effectively inhibit the activity of a staphylococcus aureus efflux pump, and the survival rate of mice infected with staphylococcus aureus can be remarkably increased when the quinolone antibiotic synergist is combined with quinolone antibiotics for use.

The present invention relates to a fragrance composition whose scent, which gives a cooling or warming sensation based on subjective evaluation when the scent is smelt, can actually change a skin temperature, that is, a cooling fragrance that can lower the skin temperature, and a warming fragrance that can increase the skin temperature.

The invention discloses an agonist of a retinoic acid receptor beta and application of the agonist in preparation of a non-small cell lung cancer medicine in the technical field of biological medicine. The agonist of the retinoic acid receptor beta is saturated odd fatty acid heptadecanoic acid C17: 0; according to the research, the expression of a retinoic acid receptor beta can be up-regulated by adding heptadecanoic acid into the NSCLC cells, so that the sensitivity of the NSCLC cells to retinoic acid treatment is improved. When heptadecanoic acid and retinoic acid are combined for use, the activity and migration ability of NSCLC cells can be further inhibited, and apoptosis of the cells is promoted. The result shows that the heptadecanoic acid plays an important role in controlling the sensitivity of the NSCLC cells to the retinoic acid, the combined use of the heptadecanoic acid and the retinoic acid provides a new drug treatment means for treating the NSCLC, and the heptadecanoic acid and the retinoic acid have potential application value in preparing the drug for treating the non-small cell lung cancer.

The present invention relates to pH-sensitive nanoparticles containing cationic substances, which can stably encapsulate a high content of active ingredients and have significantly improved skin retention and delivery effects of the active ingredients when applied to the skin, and a composition containing the same.

The invention relates to a hybrid nano assembly for dual synergistic chemotherapy as well as a preparation method and application of the hybrid nano assembly, and belongs to the technical field of pharmaceutical preparations. The invention relates to a hybrid nano assembly for dual synergistic chemotherapy, which is formed by co-assembling a cabazitaxel prodrug and gossypol under hydrophobic action and hydrogen bond driving, and is modified by adopting a PEG (Polyethylene Glycol) modifier, the molar ratio of the cabazitaxel prodrug to the gossypol is 1: (1-7), and the ratio of the total mass of the cabazitaxel prodrug and the gossypol to the mass of the PEG modifier is 4: 1. A cabazitaxel prodrug and a sensitizer gossypol are co-assembled to obtain a hybrid nano assembly, the hybrid nano assembly is oxygenated to obtain the oxygen-carrying preparation, the nano assembly and the oxygen-carrying preparation are simple and convenient to prepare and high in drug loading efficiency, and efficient co-loading of drugs can be achieved; meanwhile, the curative effect of chemotherapy can be enhanced through dual mechanisms of relieving tumor hypoxia and promoting tumor apoptosis, and the pharmaceutical composition has a good clinical application prospect.

This invention belongs to the field of antibiotics and discloses the use of a combination of trans-cinnamaldehyde and antibiotics in the preparation of medicaments for the prevention and treatment of drug-resistant bacterial infections. This antibacterial composition exhibits good inhibitory or bactericidal effects against multidrug-resistant *Streptococcus pleuropneumoniae*, *Streptococcus suis*, and *Staphylococcus suis*, can reverse drug-resistant antibiotics into sensitive ones, significantly reduce the use of commonly used antibiotics, improve efficacy, and simultaneously avoid antibiotic residues in pork products, ensuring food safety. Furthermore, this invention also provides applications of this antibacterial composition and related pharmaceutical formulations.

The invention discloses a salmonella virulent bacteriophage vBSalPNW15 and application thereof, the bacteriophage is separated from farm sewage, belongs to a long-tail bacteriophage family, has a regular icosahedron head and a long-tail structure, and keeps stable under the conditions that the pH is 4-13 and the temperature is 40-60 DEG C. Genomic analysis shows that the kit does not contain virulence genes and drug-resistant genes and is good in safety. The bacteriophage and cinnamyl aldehyde are combined to be used for preventing and treating salmonella infection, both the bacteriophage and cinnamyl aldehyde show a remarkable synergistic bacteriostatic effect (FICI = 0.5) in vitro and in vivo, and the bacteriophage and cinnamyl aldehyde can effectively inhibit growth of multi-drug-resistant salmonella, remove biological membranes, relieve tissue pathological damage and remarkably improve the survival rate of chicks. The invention provides a safe and efficient antibiotic replacement scheme for preventing and treating salmonella infection, and is suitable for the fields of livestock and poultry breeding and food safety.

The disclosure relates to solid and liquid compositions for reducing lactation, improving health, reducing the risk and or occurrence of intramammary infections, dry-off related stress, dry-off related inflammation, and / or dry-off related infections. A preferred compound is di-n-propyl disulfide.

A composition comprises β-pinene, bomeol, cinnamic aldehyde, citral, d-limonene, eucalyptol, eugenol, famesol, linalool, thymol, and vanillin. In addition, a method for use of the composition as an antibacterial and antiviral agent is also disclosed.

The application belongs to the technical field of medicine and pharmacy, and particularly relates to application of vanillin in preparation of a Klebsiella pneumoniae capsule inhibitor. The application relates to application of vanillin in preparation of an inhibitor for inhibiting formation, adhesion or function of a Klebsiella pneumoniae capsule, and related antibacterial or anti-infection products, wherein the vanillin reduces pathogenicity of Klebsiella pneumoniae by inhibiting capsule synthesis. It is disclosed that the vanillin can effectively inhibit formation of a Klebsiella pneumoniae capsule and reduce viscosity of bacteria, and can effectively treat mice infected with Klebsiella pneumoniae.

The invention relates to the technical field of oral medical materials, and particularly provides a false tooth safety paste and a preparation method thereof. The denture safety paste comprises an oil phase matrix, a gel matrix and a microcapsule functional phase, wherein the oil phase matrix is formed by melting and emulsifying beewax and vegetable oil; the gel matrix comprises fenugreek gum, locust bean gum, nano cellulose and modified aluminum metasilicate; the microcapsule functional phase comprises fenugreek gum microcapsules, and the microcapsule functional phase is dispersed in the oil phase matrix and the gel matrix. Through the three-phase synergistic effect of the oil-phase matrix, the gel matrix and the fenugreek gum microcapsule functional phase dispersed in the oil-phase matrix and the gel matrix, the high-temperature stability of the paste without layering and oil separation is realized; the quick-acting initial adhesion of the locust bean gum, the slow-release lasting adhesion of the microcapsules, the mechanical reinforcement of the nano-crystalline cellulose network and the safe antibacterial property of the bacteriostatic agent are integrated, and the problems that the existing safety and consolidation paste is softened at a high temperature, is easy to lose and is poor in biocompatibility are effectively solved.

The invention provides a composite antibiotic-replacing microcapsule preparation as well as a preparation method and application thereof. The composite antibiotic-replacing microcapsule preparation comprises a core material as well as an inner-layer wall material and an outer-layer wall material which are sequentially coated outside the core material, wherein the core material comprises a Chinese herbal medicine extract, plant essential oil and probiotics, the Chinese herbal medicine extract comprises forsythin, astragalus polysaccharide and atractylenolide III, the plant essential oil comprises origanum oil and cinnamyl aldehyde, and the probiotics comprise bacillus subtilis; the inner-layer wall material is prepared by crosslinking sodium alginate and calcium chloride, and the outer-layer wall material comprises chitosan. The traditional Chinese medicine composition has the characteristics of synergistic interaction, high stability and good intestinal tract targeting property, and can improve the resistance replacement effect.

The invention provides a 9, 10-dihydrophenanthrene compound and application thereof in liver injury treatment, and particularly provides a compound shown as a formula I or a compound shown as a formula II, which shows anti-inflammatory and antioxidant activity in liver tissues, so that the 9, 10-dihydrophenanthrene compound can be used for treating liver injury diseases, such as liver injury diseases and liver injury diseases. Particularly, the liver injury diseases with inflammation and lipid peroxidation as pathological basis can be treated or prevented. # imgabs0 #

Provided a composition or a kit based on triptolide, gossypol and acceptable salts thereof. The current composition or kit based on triptolide, gossypol and acceptable salts thereof can be used for limiting or inhibiting birth rate including the induction of infertility.

The invention relates to a preparation method of an animal anti-diarrhea feed additive containing delinted moxa powder and essential oil. The preparation method of the animal anti-diarrhea feed additive containing the delinted moxa powder and the essential oil comprises the following steps: mixing essential oil components thymol and cinnamyl aldehyde, and stirring at 35-65 DEG C until the essential oil components are dissolved to obtain an essential oil solution; the preparation method comprises the following steps: mixing antioxidants BHA and PG, citric acid and ethanol, and stirring until dissolving to obtain an ethanol solution; mixing the ethanol solution with stone powder, and drying to remove ethanol to obtain a solid mixture; mixing the solid mixture with the essential oil solution, adding delinted moxa powder, and stirring uniformly; according to the preparation method of the animal anti-diarrhea feed additive containing the delinted moxa powder and the essential oil, stable combination of the essential oil and the delinted moxa powder is achieved, the diarrhea morbidity and mortality are remarkably reduced in animal experiments, and the effect is better than that of independent use of the essential oil.

This invention relates to the field of functional food technology, and more particularly to the application of safflower honey, or safflower honey extract, in enhancing the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). The invention has found that safflower honey, or safflower honey extract, can effectively enhance ADH and ALDH activity, thereby promoting alcohol metabolism and achieving a hangover-relieving effect. Further research on the extract revealed that a mixture of syringaldehyde, riboflavin, lutein, luciferin, and three p-coumaroyl spermidine plays a key role in enhancing ADH and ALDH activity, thus providing an application of this mixture in hangover relief. The application of safflower honey and its extract provided by this invention has high application value for developing foods and health products with hangover-relieving effects.

Various methods and compositions of treating 4-hydroxyphenylpyruvate dioxygenase-like (HPDL)-related diseases or disorders are presented herein. Also presented herein are methods of increasing CoQ10 biosynthesis, and methods of determining whether a subject will benefit from a CoQ10 or CoQ10 alternative treatment. Also presented herein are pharmaceutical compositions and dosage forms comprising 4-hydroxymandelic acid (4-HMA), and / or its metabolites. Further presented herein are compounds that inhibit 4-hydroxyphenylpyruvate dioxygenase-like (HPDL). Further presented herein are methods of identifying and / or assessing modulators of HPDL. Yet further presented herein are example methods and systems for isotopic labelling in cells by metabolizing cells in the presence of gaseous isotopic tracer.

The objective is to suppress or improve the decline in cognitive function speed or reaction time. [Solution] The above problem can be solved by a composition for suppressing or improving the decline of cognitive function speed or reaction time, which contains cumin aldehyde, or cumin (Cuminum cyminum) containing cumin aldehyde or a processed product thereof.