465results about "Aldehyde active ingredients" patented technology

The invention belongs to the technical field of medicines, cosmetics and scalp care, and particularly relates to application of coniferaldehydes and derivatives or salts of the coniferaldehydes to preparation of medicines and cosmetics for promoting hair regeneration and treating chemotherapy-induced alopecia (CIA, CIA) and other types of alopecia, in particular to application of the coniferaldehydes and the derivatives or salts of the coniferaldehydes to preparation of the medicines and the cosmetics. Experimental results show that coniferyl aldehyde can promote hair regeneration of mice, accelerate hair growth of the mice and effectively relieve alopecia symptoms of the mice after chemotherapy, and the effect of coniferyl aldehyde is better than that of minoxidil. According to the application, coniferyl aldehyde or a composition thereof is given to a subject, so that the vigor of hair follicles is remarkably enhanced, the stationary period of the hair follicles is shortened, and the hair loss process is inhibited. The coniferyl aldehyde provided by the invention has the industrial application advantages of reliable biological safety, controllable preparation cost and high raw material accessibility, can be obtained by a plant extraction or chemical synthesis method, is suitable for an external solution, gel or a scalp care preparation, and provides a natural, safe and effective solution for alopecia patients.

Disclosed herein are compositions of matter suitable for use in foods, feeds, pharmaceuticals and cosmetic care products, the compositions of matter comprising a retinoid component and fermentation residues thereof. In embodiments, the retinoid component is present in a weight ratio relative to the fermentation residue of 4: 1 or greater, where the retinoid contains cis-isomer and trans-isomer, where the cis-isomer is present in an amount of less than 3% by weight relative to the entire isomer mixture. Preferably, the composition is bio-based. Also described are biotechnological methods for producing the compositions otherwise described, as well as additional methods for processing such compositions into more stable, more commercially acceptable forms. Finally, foods, feeds, pharmaceuticals, and cosmetic care products incorporating the compositions described herein are also disclosed.

The invention relates to an o / w type high-content composite essential oil nanoemulsion and a preparation method and application thereof.The median particle size of the composite essential oil nanoemulsion is not larger than 45 nm, and the composite essential oil nanoemulsion comprises plant essential oil, polyethylene glycol glycerol ricinoleate with the HLB value being 10-14, a cosolvent, water, vitamin E acetate and ethylene diamine tetraacetic acid disodium salt. The plant essential oil is selected from two or more of carvacrol, cinnamyl aldehyde, capsicum oleoresin and thymol. The compound essential oil nanoemulsion solves the key technical problem of high-content load compound nanoemulsion of various plant essential oils, is beneficial to exerting the synergistic effect of different essential oils, and reduces the addition amount of the essential oils while achieving the same physiological function. Besides, the particle size of the composite essential oil nanoemulsion reaches the nanoscale, the composite essential oil nanoemulsion can form homogeneous-phase clear liquid, can be quickly diffused in a waterline or a water environment, is more beneficial to absorption, has the advantages of good stability and long storage life, and is more competitive in practical application.

The present invention relates to a composition comprising (i) an extract of Crocus sativus comprising at least safranal, and (ii) an extract of Cannabis sativa comprising cannabidiol (CBD) and uses thereof as a pharmaceutical product, a food supplement, a nutritional product, a cosmetic product, or a liquid suitable for electronic cigarettes.

The invention belongs to the technical field of biological materials, and particularly relates to a conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity and a preparation method of the conductive hydrogel microneedle patch. The preparation method comprises the following steps: firstly, loading plant essential oil with antibacterial and anti-inflammatory activity on mesoporous polypyrrole nanoparticles to prepare drug-loaded nanoparticles, then preparing a pre-hydrogel mixture containing the drug-loaded nanoparticles, and then filling the mixture into a PDMS microneedle mold to obtain the conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity. The prepared microneedle patch not only has excellent antibacterial and anti-inflammatory activity and a conductive function, but also has the characteristics of a microneedle and hydrogel, and can deliver a drug to a skin cuticle or a lower layer of a bacterial biofilm, so that the bioavailability of transdermal drug delivery of the drug is greatly improved. Besides, the microneedle patch is swelled after absorbing tissue exudate, is adhered to the surface of skin or other mucous membranes to continuously play antibacterial and anti-inflammatory roles and conductive functions, and provides wet healing conditions, so that high-quality healing of skin wounds is accelerated.

The invention discloses a nerve cell senescence resisting medicine containing p-hydroxybenzaldehyde and application thereof.The p-hydroxybenzaldehyde is adopted as the only active substance, and the p-hydroxybenzaldehyde can reduce accumulation of DNA damage in cells, reduce activity of beta-galactosidase in the cells and slow down reduction of cell metabolic capacity, so that the nerve cell senescence resisting medicine is obtained. Therefore, the senescence of nerve cells is effectively slowed down, the cognitive function is improved, and a potential treatment effect is achieved in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

The invention discloses an anti-tumor drug delivery system based on click chemistry and a hollow covalent organic framework material as well as a preparation method and application of the anti-tumor drug delivery system, and belongs to the technical field of novel biomedical materials. The anti-tumor drug delivery system based on the click chemistry and the hollow covalent organic framework material comprises a bowl-shaped hollow covalent organic framework material carrier, and a click chemistry prodrug 1 and a click chemistry prodrug 2 which are loaded in the bowl-shaped hollow covalent organic framework material carrier, the click chemistry prodrug 1 is a compound containing an aldehyde group, and the click chemistry prodrug 2 is a compound containing an amino group. By combining the high-specificity reaction of click chemistry with the excellent drug loading performance of HCOF, accurate drug release can be realized in a tumor-specific microenvironment, the toxicity of normal cells can be remarkably reduced, the treatment effect is improved, and a wide clinical application prospect is shown.

Methods of treating, suppressing, or reducing the severity of a liver cancer in a subject are described herein. The disclosed methods involve administering a therapeutically effective amount of a composition including safranal or its pharmaceutically acceptable pro-drug, and a pharmaceutically acceptable carrier to the subject. The disclosed methods may be used to treat, suppress, or reduce the severity of various liver cancers, including hepatocellular carcinoma (HCC), fibrolamellar HCC, cholangiocarcinoma, angiosarcoma, a metastatic liver cancer, and combinations thereof.

The invention discloses oral brain-targeted nanoemulsion as well as a preparation method and application thereof, and belongs to the field of biological medicine preparations. Drug molecules and a stabilizer are dispersed in oil phase molecules, and then a surfactant and water are added to prepare the nano-emulsion. Drug molecules are dispersed in oil-phase molecules and then form an oil-in-water nanoemulsion with water, so that the problems of poor stability and poor water solubility of current drug molecules are solved, the oral bioavailability of the drug is improved, fusion of different drug molecules of multiple targets is realized, the drug loading capacity of the drug molecules can be effectively ensured, and the bioavailability of the drug is improved. In addition, the drug can pass through an intestinal barrier and a blood brain barrier to be successfully delivered to a brain region to realize multi-target treatment, so that efficient treatment of multi-target brain diseases such as neurodegenerative diseases and central nervous system tumors is realized.

The invention provides a compound as shown in a formula I, or pharmaceutically acceptable salt or ester, prodrug, optical isomer, stereoisomer or solvate thereof. The compound disclosed by the invention can be used for preparing medicines for preventing or treating pain and related diseases thereof, so that a brand new material basis is laid for developing the pain and the related diseases thereof. # imgabs0 #

The invention provides application of coniferyl aldehyde in eye protection products, and belongs to the technical field of eye health. The coniferyl aldehyde is found to have an eye protection effect for the first time, and particularly has a protection effect on retina light injury. Cell model and animal model experiments prove that coniferyl aldehyde has a protective effect on eye cell apoptosis, retina light injury and the like, so that coniferyl aldehyde can be applied to development and application of drugs for treating retina light injury diseases and functional products for relieving visual fatigue and the like.

The invention provides a difluoromethoxy phenyl compound as shown in formula (I), or pharmaceutically acceptable salts, solvates, hydrates, prodrugs, stereoisomers, polymorphs, eutectic crystals or isotope markers of the difluoromethoxy phenyl compound, and application of the difluoromethoxy phenyl compound and the pharmaceutically acceptable salts, solvates, hydrates, prodrugs, stereoisomers, polymorphs, eutectic crystals or isotope markers in medicine, and the difluoromethoxy phenyl compound and the pharmaceutically acceptable salts, solvates, hydrates, prodrugs, stereoisomers, polymorphs, eutectic crystals or isotope markers can be used for preparing anti-tumor drugs # imgabs0 #.

The invention provides a composition and a method for sow simultaneous delivery and application of the composition and the method, and particularly discloses a composition and a method for shortening the delivery process and improving the live piglet rate according to a sow simultaneous delivery scheme applying vitamin B6, mifepristone, cloprostenol sodium and carbetocin. According to the composition, aiming at the problem that the sow production efficiency is influenced by the reduction of the live piglet rate caused by the simultaneous delivery of sows, the vitamin B6 and the mifepristone are combined on the basis of the delivery drugs cloprostenol sodium and carbetocin, so that a set of new simultaneous delivery scheme is formed; according to the method, the delivery process of the sows is shortened, the live piglet rate of the sows is increased, the method is a method for improving the same-period delivery effect of the sows in batches, and great value is provided for improving the PSY of the sows and promoting batch management of the sows.

The invention provides a bacteriostatic agent aiming at yersinia enterocolitica and application, the bacteriostatic agent comprises a compound solution of lipoic acid and protocatechualdehyde, and when the lipoic acid and the protocatechualdehyde act synergistically, the minimum inhibitory concentrations to the yersinia enterocolitica are 0.625 mg / mL and 0.3125 mg / mL respectively. The yersinia enterocolitica biofilm is inhibited and / or removed through the lipoic acid and protocatechuic aldehyde compound liquid, and the problem that drugs for treating the yersinia enterocolitica infection are prone to drug resistance is solved.

Compositions and methods are disclosed herein for inducing (up-regulating) the expression and / or activity of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and / or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH. Additionally, methods for preparing a stable liposomal containing solution are described.

The present disclosure relates to methods for evaluating the ability of test fragrance ingredients or test fragrance compositions to improve an invigorated state in a human subject, and for creating fragrance compositions that have a positive revitalizing effect on a human subject, as well as fragrance compositions for improving an invigorated state in a human subject, consumer products comprising such fragrance compositions, and methods for improving an invigorated state in a human subject.

The invention provides an active oxygen and active nitrogen cascade anti-tumor nano-drug aiming at tumor treatment obstacles of insufficient hydrogen peroxide and ultra-short service life of nitric oxide in tumors, and the combined effect of plant aldehyde and natural amino acid is taken as the core content of anti-tumor treatment. Nanoparticles are used as a carrier, the carrier is coated with a biocompatible material, plant aldehyde is loaded or grafted, and natural amino acid is packaged. In a tumor acidic environment, the plant aldehyde releases hydroxyl radicals to realize active oxygen therapy. When hydroxyl radicals are generated, hydrogen peroxide can be slowly released by the plant aldehyde, then natural amino acid is triggered to be converted into nitric oxide, and active nitrogen therapy is achieved. The controlled release of the plant aldehyde enables the release of the nitric oxide to be controllable, and the realization of space-time release of the active oxygen and the nitric oxide is realized, so that the complementarity of the active oxygen and the nitric oxide in pharmacokinetics is fully utilized, and a strong anti-tumor effect is generated. The preparation method is easy to operate, the raw materials are easy to obtain, and the prepared nano-particles loaded with the plant aldehyde and the natural amino acid have good particle dispersity, chemical stability and biocompatibility and are an ideal chemical-gas therapy-ferroptosis cascade cancer treatment reagent.

Described herein are compositions for delaying onset or delaying progression of frailty, reversing aging phenotype, extending healthspan, compressing morbidity, increasing lifespan and reducing formation of senescent cells.

The invention provides a composition for inhibiting tumor growth and a preparation method thereof, and belongs to the technical field of medicines. After selenium is loaded, folic acid is coupled, and folic acid-selenium polysaccharide nanoparticles are prepared; notoginsenoside, curcumin, alizarin and hairyvein agrimony phenolic acid are embedded in pH-sensitive lipidosome, and the pH-sensitive lipidosome is uniformly mixed with folic acid-selenium polysaccharide nanoparticles and semicarbazone compounds to prepare the composition for inhibiting tumor growth. The composition for inhibiting tumor growth prepared by the invention has a relatively good anti-tumor effect, can release active components in a targeted manner at a tumor part, can reverse drug resistance, reduce the dosage of chemical drugs, reduce toxicity and improve patient compliance, is high in bioavailability, and has a wide application prospect.

The invention discloses a diisoprene derivative as shown in a structural general formula (I) and a structural general formula (II), or pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, the diisoprene derivative has the activity of regulating the expression of a low-density lipoprotein receptor (LDLR), and can inhibit tumor cell proliferation, control inflammatory factor release, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation, inhibit tumor cell proliferation and inhibit tumor cell proliferation. The accumulation of retinal lipofuscin is reduced, macular degeneration is improved, and retinal injury is relieved. The diisoprene derivative can be used for treating diseases related to abnormal lipid metabolism, such as cardiovascular diseases, metabolic diseases, cancer, inflammation, retinal diseases and / or other diseases. # imgabs0 #

The invention relates to the technical field of plant extraction, and provides a plurality of phenolic compounds in senecio scandens, and a preparation method and application thereof. The method comprises the following steps: crushing senecio scandens, adding ethyl acetate, and performing ultrasonic heating, stirring and extracting to obtain an extracting solution; carrying out rotary evaporation and vacuum concentration on the extracting solution to obtain a crude extract; dissolving the crude extract by using absolute ethyl alcohol through ultrasonic heating, carrying out gradient elution through a macroporous adsorption resin chromatographic column, and collecting an ethanol water eluent; and concentrating the ethanol water eluent under reduced pressure, stirring with a reverse-phase filler, loading with a dry method, packing with a wet method, and sequentially performing isocratic elution with a reverse-phase chromatographic column and purification with a gel column. The dissolution efficiency of phenolic compounds in senecio scandens is improved through ultrasonic and mild heating, the problems that components are degraded due to high temperature in traditional reflux extraction and time and solvent are consumed in dipping extraction are solved, and target component residues are reduced; and then through gradient elution of a chromatographic separation column, isocratic elution of a reversed-phase chromatographic column and purification of a gel column, the problem that phenols are similar in structure and easy to co-elute is accurately solved.

The present disclosure relates to compositions for improving gut health and / or milk production in ruminants, comprising: at least one organic acid chosen from sorbic acid, fumaric acid, malic acid, lactic acid, citric acid, formic acid, salts thereof and mixtures thereof; at least one essential oil chosen from thymol, eugenol, vanillin, thyme oil, carvacrol, cinnamaldehyde, clove leaf essential oil, and mixtures thereof; at least one bacterial fermentation product chosen from bacterial fermentation products of a Bacillus fermentation product, a Streptomyces fermentation product, an Aspergillus fermentation product, a Streptococcus fermentation product, a Paenibacillus fermentation product and mixtures thereof; at least one plant extract chosen from a saponin, a Yucca extract, a Quillaja extract and mixtures thereof; and at least one controlled release matrix.

The present disclosure generally relates to coolness-modifying compositions that enhance the cooling effect of cooling compounds, such as menthol, cubebol, and the like. In some aspects, the disclosure provides uses of such coolness-modifying compositions to cooling effect of cooling compounds. In some other aspects, the disclosure provides compositions (such as comestible compositions or oral care compositions), which comprise a cooling compound (for example, menthol, cubebol, and the like) and a coolness-modifying composition of the present disclosure. In some embodiments, such compositions are in the form of a food product, a beverage product, or an oral care product, such as a toothpaste, a mouthwash, a tooth-whitening composition, a chewing gum, a dentifrice, and the like. In some other embodiments, such compositions are in the form of a body care product, such as a cosmetic product, a skin care product, or a hair care product.

The invention belongs to the technical field of natural pharmaceutical chemistry and medical application, and discloses a quinolone antibiotic synergist and application thereof in preparation of a medicine for treating bacterial infection. The structural formula of the quinolone antibiotic synergist is shown in the specification. The quinolone antibiotic synergist can effectively inhibit the activity of a staphylococcus aureus efflux pump, and the survival rate of mice infected with staphylococcus aureus can be remarkably increased when the quinolone antibiotic synergist is combined with quinolone antibiotics for use.

The invention discloses aztreonam microspheres as well as a preparation method and application thereof. The microsphere is an inhalation preparation and can be effectively deposited in the lung, so that the slow release of the medicine is realized. According to the aztreonam microspheres, aztreonam and cinnamyl aldehyde are synthesized into a small molecule drug, and the small molecule drug is self-assembled into the microspheres. The preparation method comprises the following steps: (1) placing aztreonam AZT and cinnamyl aldehyde CA in a glass bottle according to a molar ratio of 3: 2, adding dimethyl sulfoxide DMSO, stirring and dissolving, and stirring and reacting at room temperature for 5-7 hours; (2) dialyzing the reacted solution in a dialysis bag, removing DMSO and unreacted small molecules, and obtaining dialysate after 48 hours; (3) performing freeze drying to obtain yellow powder of cinnamyl aldehyde-aztreonam CAT; and (4) weighing the CAT powder, dissolving the CAT powder in deionized water, and shaking to dissolve the CAT powder to obtain the aztreonam microspheres. The microspheres are suitable for treatment of pulmonary infections, in particular for local drug delivery and sustained release control.

The present invention relates to a fragrance composition whose scent, which gives a cooling or warming sensation based on subjective evaluation when the scent is smelt, can actually change a skin temperature, that is, a cooling fragrance that can lower the skin temperature, and a warming fragrance that can increase the skin temperature.

The invention discloses an agonist of a retinoic acid receptor beta and application of the agonist in preparation of a non-small cell lung cancer medicine in the technical field of biological medicine. The agonist of the retinoic acid receptor beta is saturated odd fatty acid heptadecanoic acid C17: 0; according to the research, the expression of a retinoic acid receptor beta can be up-regulated by adding heptadecanoic acid into the NSCLC cells, so that the sensitivity of the NSCLC cells to retinoic acid treatment is improved. When heptadecanoic acid and retinoic acid are combined for use, the activity and migration ability of NSCLC cells can be further inhibited, and apoptosis of the cells is promoted. The result shows that the heptadecanoic acid plays an important role in controlling the sensitivity of the NSCLC cells to the retinoic acid, the combined use of the heptadecanoic acid and the retinoic acid provides a new drug treatment means for treating the NSCLC, and the heptadecanoic acid and the retinoic acid have potential application value in preparing the drug for treating the non-small cell lung cancer.

The present invention relates to pH-sensitive nanoparticles containing cationic substances, which can stably encapsulate a high content of active ingredients and have significantly improved skin retention and delivery effects of the active ingredients when applied to the skin, and a composition containing the same.