161 results about "Quinolone antibiotic" patented technology

The present invention provides pharmaceutical aerosols which are useful for the prevention or treatment of infectious diseases of the airways, such as the lungs, the bronchi, or the sinunasal cavities. The aerosols comprise an active agent selected from the group of quinolone antibiotics. Also disclosed are liquid and solid compositions suitable for being converted into the aerosols, and kits comprising such compositions.

The invention relates to a method for preparing a magnetic charcoal material, a device adopting the method and application. The method comprises the following steps that sewage treatment plant sludgeis subjected to high-temperature anaerobic pyrolysis, and sludge charcoal is obtained; then dry fine grinding is carried out, and charcoal powder is obtained; the sludge charcoal powder is subjected to dry magnetic separation, a magnetic material is obtained, granules obtained after humidifying and pelleting are subjected to high-temperature sintering in protective atmosphere, and sintered materials are obtained; furnace cooling is carried out, and the magnetic charcoal material of a porous structure is obtained. According to the method, the magnetic material is separated out of the sludge pyrolysis product charcoal and is used for preparing the magnetic charcoal material, the magnetic charcoal material is used for efficiently adsorbing and removing quinolone antibiotics such as ciprofloxacin, recycling utilization of the sludge charcoal is achieved, the preparation cost of the adsorption materials is reduced, the process is simple, high practicality is achieved, and good economic benefits and environmental benefits are achieved.

The invention relates to a method for separation enrichment and detection of trace fluoroquinolone antibiotic residues in a water environment. According to the method, 2.0-4.0L of a water sample is subjected to solid-phase extraction, and then analysis and detection are carried out by a liquid chromatography-mass spectrometry instrument. Being able to well separate and detect a plurality of fluoroquinolone antibiotic substances, the invention has the advantages of low detection limit, high recovery rate, high sensitivity, good selectivity and simple operation, etc., and has substantial effects in the detection study of trace fluoroquinolone antibiotic substances in the water environment.

The invention provides a method for removing antibiotic contamination by adsorption of copper sulphide, and belongs to the field of water pollution control. The method comprises the steps of filtering waste water containing antibiotic contamination, adjusting pH to 5-9; and filtering the waste water processed in the step (1) through a bed layer containing the copper sulphide, wherein the antibiotic contamination is any one of tetracyclines, penicillins, macrolides, and sulfonamide fluoroquinolone antibiotic. Compared with the traditional removal technology of the antibiotic in a water body, the method disclosed by the invention has the beneficial effects that 1 the antibiotic contamination in the water body can be selectively complexed and removed; and the effluent concentration can be less than 1mug/L; 2, the adsorbing capacity is large; and the adsorbing capacity of copper sulphide can be up to 500mg/g; and 3, the method is fast in adsorption rate, easy to regenerate, simple and convenient to operate, low in cost and free of secondary pollution.

Belonging to the technical field of water treatment, the invention relates to preparation of a magnetic reduced graphene oxide composite material. The method includes: (1) placing graphene oxide into ethylene glycol to undergo ultrasonic treatment; (2) dissolving sodium citrate in ethylene glycol to undergo heating reaction; (3) mixing FeCl3.6H2O with urea, then dissolving the mixture into a sodium citrate/ethylene glycol solution under magnetic stirring to obtain an ethylene glycol mixed solution of the iron salt and urea; (4) stirring and mixing the graphene oxide/ethylene glycol mixed solution and the ethylene glycol mixed solution of the iron salt and urea obtained in the preceding step to undergo reaction, then transferring the reaction product into a reaction kettle to undergo heating reaction and cooling; and (5) subjecting the obtained material to centrifugation, washing and filtering, and freeze drying, thus obtaining the product involved in the invention. The magnetic reduced graphene oxide prepared by the method provided by the invention has the advantages of pure crystal phase, difficult agglomeration, and high magnetization degree. Also, the process is simple and has low requirements for production equipment. The invention also relates to a method for removing quinolone antibiotics from water by the composite material.

The invention discloses primers and a kit for detecting the quinolone drug-resistance genes of bacteria, and belongs to the technical field of microbiological detection. The sequences of the primers for detecting the quinolone drug-resistance genes of bacteria provided by the invention are shown in SEQ ID NO: 1-6, and the three primer pairs are capable of specifically amplifying the three quinolone drug-resistance genes of qnrA, qnrB and qnrS of multiple bacteria. The invention further discloses a kit for detecting the quinolone drug-resistance genes of bacteria, wherein the kit contains an EvaGreen fluorescent dye, and is capable of rapidly and accurately detecting the quinolone antibiotic-related drug-resistance genes of bacteria. The primers and the kit disclosed by the invention have the advantages of simplicity and convenience in operation, high specificity, high sensibility, low cost, high flux and the like, and can be used for rapidly detecting quinolone antibiotic-related drug-resistance genes of clinic pathological bacteria and providing a reference for clinic treatment.

The invention discloses a preparation method of a microwave-assisted magnetic hollow Zn/Co zeolite imidazole nanocage material. The preparation method comprises the steps: adopting Nano Fe3O4 as a seed crystal, adding cobalt nitrate hexahydrate and 2-methylimidazole and zinc nitrate hexahydrate successively, performing rapid self-assembly based on seed crystal induction so as to form a double-shell Zn/Co-ZIF crystal and form a magnetic double-shell nano crystal Fe3O4@ZIF-67@ZIF-8, utilizing methanol to absorb the microwave energy under the assistance action of microwaves, and transferring energy quickly to an inner shell ZIF-67 with poor chemical stability so as to bring vibration and cracking of metal organic skeleton ZIF-67 bonds, achieve etching of the inner shell and obtain Fe3O4@Zn/Co-ZIF. The material has a hollow cage-shaped morphology, a large specific surface area, a complete crystal form, multiple pores, high chemical stability and good magnetic properties for convenient magnetic separation. The material has an efficient and high-throughput adsorption for antibiotic quinolone drugs, has another advantage of easy separation from the antibiotic quinolone drugs, can be regenerated and reused at least 8 times, has excellent reproducibility, and has easy realization of high-efficiency removal of high-residue quinolone antibiotics in a large-scale water environment.

The invention belongs to the technical field of degradation of soil organic pollutants, and discloses a composite microbial preparation for degrading quinolones antibiotics and a preparation method and application. The preparation method comprises the steps of mixing quinolones antibiotics degradation bacterial liquid with energy supply bacterium bacterial liquid, magnetic medium bacterium bacterial liquid, a surfactant and a fermentation medium to obtain mixed liquid; and performing fermentation to obtain the composite microbial preparation for degrading the quinolones antibiotics. Energy supply bacteria which are adopted enable the composite microbial preparation to have high colonization and multiplication capacity in in-place edatope. The surfactant and the magnetic medium bacteria, which are adopted, enable the composite microbial preparation to have low moisture tension and antibiotics polarity. The prepared composite microbial preparation is high in activity, and high in environmental suitability. The composite microbial preparation is used for degradation of the quinolones antibiotics in soil, and is broad in scope of application and high in degradation efficiency.

The invention provides an aspartate quinolone antibiotics water-soluble salt and the injection formulation thereof, including sparfloxacin, gatifloxacin, rufloxacin, pefloxacin, tosufloxacin, moxifloxacin, and so on; the invention improves the water solubility of quinolone antibiotics and enhances the anti-bacterial effect of quinolone antibiotics. Compared with the oral liquid of quinolone drugs of the prior art, the invention has the advantages that: water solubility of the drug is good, as the drug enters the blood directly, the invention can not only achieve treatment function rapidly, but can also be absorbed by the human body fully, and the invention has significant effects in the two aspects of fast onset of action and low consumption. Compared with the injection of the quinolone drugs of the prior art, the invention has the advantages that: due to the existence of the L-aspartate, the antibacterial activity of quinolone drugs can be enhanced.

The invention belongs to the field of water supply and sewerage works/environmental engineering, and discloses a method for targeted degradation of quinolone antibiotics in water and a multiband ultraviolet (UV) radiation device used for the method. The method for targeted degradation of the quinolone antibiotics in water includes the following steps that wastewater containing the quinolone antibiotics is added with a H2O2 aqueous solution and/or aqueous solution containing S2O8<2>, and then the wastewater is degraded under the multiband UV radiation action, so that a water body for targeted degradation of the quinolone antibiotics is obtained. The invention further provides the multiband UV radiation device used for the method. According to the method, the multiband UV radiation device independently designed and developed is used as the main body to be combined with the H2O2 and S2O8<2>, so that a composite UV degradation technology is formed, and the technology can be used in a water supply treatment plant or wastewater treatment plant; and electric energy serves as the driving energy, UV radiation serves as the excitation energy, the H2O2 or S2O8<2> serves as the oxidizing agent donor, efficient targeted degradation of ciprofloxacin is realized, and finally the antibacterial activity and toxicity are weakened.

The invention relates to a fluorescent microsphere immune test paper card for detecting quinolone antibiotics and preparation and detection methods and belongs to the field of immunological detection.The test paper card comprises a card shell and a test paper strip. The test paper strip comprises a bottom plate, and a water absorption pad, a detection pad, a combining pad and a sample pad successively overlapped and adhered to the bottom plate; the detection pad is a nitrocellulose membrane provided with a quality control line C and a detection line T, the quality control line C is coated with a goat anti mouse monoclonal antibody and the detection line T is coated with an enrofloxacin-bovine serum albumin conjugate; the combining pad is a glass cellulose membrane of the enrofloxacin monoclonal antibody embedded with a time-resolved fluorescent microsphere label; the sample pad is a dried glass cellulose membrane immersed in a sample treatment liquid; the bottom plate is a PVC plate which does not absorb water, and the water absorption pad is water absorbing filter paper. The test paper card prepared is good in stability, high in sensitivity and high in specificity, can detect 16quinolone antibiotics, and can achieve the purpose of quantitative and batch detection of enrofloxacin quickly through fluorescence signals.

The present invention relates to a biochemical treatment reactor for waste water containing quinolone antibiotics, the reactor is composed of CAF (Composite Anaerobic Filter) and FBBR (Fixed Bed Membrane Bioreactor). Such pollutants are decomposed into small molecular compounds, and then degraded by microorganisms in the aerobic reactor, so as to achieve the purpose of removing such pollutants. By improving the traditional reactor, the present invention not only solves the problem that antibiotic wastewater containing quinolone compounds is difficult to biodegrade, but also solves the problem of mud run-off and difficult acclimation in traditional reactors, and opens up a new path for the treatment of this type of antibiotic wastewater new way.

An antibiotic polymer combination/antibiotics polymer combination that ensures the continuous release of antibiotics over a period of several days under physiological conditions, and that can be used in human and veterinary medicine. Surprisingly, one or more antibiotic salts, which are sparingly soluble in water, from the groups comprising aminoglycoside antibiotics, lincosamide antibiotics, tetracycline antibiotics, glycopeptide antibiotics, quinolone antibiotics and chlorhexidine, are suspended in homogeneous polymer mixtures, which comprise one or more hydrophobic, nonionic polymers from the groups comprising poly(vinyl, chloride), post-chlorinated poly(vinyl chloride), poly(vinylidene chloride), poly(vinyl fluoride), poly(vinylidene fluoride) and copolymers comprising vinyl chloride and one or more nonionic monomers, and which comprise one or more hydrophilic polymers from the groups comprising polyethers, and this suspension forms composites that exhibit the release of an active ingredient over a period of days in an aqueous medium.

The invention provides a magnetic nano-microsphere and a method for extracting and analyzing five trace quinolone antibiotics in a water body by virtue of the magnetic nano-microsphere. The magnetic nano-microsphere is Fe3O4@Cys@MIL125-NH2. By taking a magnetic solid phase extraction technique as the basis and the magnetic nano-microsphere as an adsorbent, the quinolone antibiotics in a to-be-tested water body are pretreated and enriched, so that the sensitivity of the method for detecting the trace quinolone antibiotics in the water body is greatly improved.

A Pazhushaxing methanesulphonate injection including its freeze dried one is prepared from the Pazhushaxing methanesulphonate, water for injection and additive.

The invention discloses a near infrared antibiotic fluorescent probe detecting agent and a preparing method and application thereof. The near infrared antibiotic fluorescent probe detecting agent comprises a fluorescent nanometer material. The excitation spectrum of the fluorescent nanometer material and the absorption spectrum of antibiotics are at least partly overlapped so that the excitation wavelength of the fluorescent nanometer material can be absorbed by the antibiotics and the fluorescence of the fluorescent nanometer material can be quenched. The fluorescent nanometer probe agent which is high in selectivity, high in detection sensitivity, simple and feasible and can be used for detecting tetracycline and carbostyril antibiotics is established according to the principle of the internal filtering effect formed between near infrared carbon quantum dots and other fluorescent nanometer materials and the antibiotics, the selectivity of the fluorescent nanometer probe is improved,the technical problem that an existing antibiotic detecting probe is not enough in sensitivity and complicated in detecting process can be solved, the detecting agent has a remarkable effect when usedfor detecting actual samples, and the detecting agent can be easily designed into a sensor for detecting the antibiotics in the actual samples on site.

The invention discloses a culture medium and a preparation method for selective separation culture extensively drug-resistant pseudomonas aeruginosa. Culture supernatant fluid and an antibiotic combination for pseudomonas aeruginosa in a logarithmic phase are added into an NAC basal culture medium. The culture supernatant fluid contains quorum sensing substances secreted by pseudomonas aeruginosa, the quorum sensing substances can accelerate growth of bacteria and promote secretion of aeruginosa pigments, and the detection time is greatly shortened. The antibiotic combination comprises carbapenems antibiotics, aminoglycoside antibiotics and quinolone antibiotics, the additive amount of the carbapenems antibiotics is 0.016 g/L, the additive amount of the aminoglycoside antibiotics is 0.016 g/L, and the additive amount of the quinolone antibiotics is 0.016 g/L, the antibiotic combination can specifically inhibit growth of sensitive pseudomonas aeruginosa strains and growth of single-drug resistant pseudomonas aeruginosa strains, the purpose of selective separation culture of extensively drug-resistant pseudomonas aeruginosa is achieved, and specificity and sensitivity are high. Moreover, the culture medium can be stored for a long time and can be effectively applied to quick detection of extensively drug-resistant pseudomonas aeruginosa in clinical samples.

The invention discloses a method for determining 10 quinolone antibiotics in bean sprouts by an ultra-high performance liquid chromatography-tandem mass spectrometry, which is characterized by comprising the following steps of: preprocessing; preparing a standard solution; obtaining a liquid chromatography mass spectrogram and a regression equation; and analyzing and detecting samples by the ultra-high performance liquid chromatography-tandem mass spectrometry. A ultra-high performance liquid chromatography-electrospray tandem mass spectrometry is adopted in this study to carry out an analysisand determination of enrofloxacin, ciprofloxacin, norfloxacin, pefloxacin, ofloxacin, sarafloxacin, danofloxacin, sparfloxacin, fleroxacin and lomefloxacin in the bean sprouts. Sample extraction conditions, purification means, liquid chromatography-mass spectrum parameters and the like are optimized and the matrix effect of the method is evaluated. The result shows that an establishment of the method solves the problem of a simultaneous determination of various quinolone antibiotics in the bean sprouts and provides a technical reference for risk assessment and government supervision.

The invention provides a three dimensional-similar electro-Fenton water treatment system and a method used for degrading carbostyril antibiotics. The three dimensional-similar electro-Fenton water treatment system comprises a reactor; the reactor comprises a three dimensional-similar electro-Fenton reaction zone and a biological filter material reaction zone; iron pyrite roasting slag based Co/Fe<0> particle electrodes are arranged at the three dimensional-similar electro-Fenton reaction zone; a biological filtering material is introduced into the biological filter material reaction zone; wastewater is subjected to common treatment by microorganisms on the biological filtering material so as to reduced COD and ammonia nitrogen to a certain degree, and then is delivered into the three dimensional-similar electro-Fenton reaction zone for deep treatment of substances difficult to be biodegraded; a persulfate is introduced into the reactor using an agent adding device, wastewater is delivered into the reactor, and is mixed with the persulfate. Under the action of particle electrode-loaded Fe<0> at the three dimensional-similar electro-Fenton reaction zone, the persulfate is activated so as to generate sulfate free radicals, hydroxyl free radicals are generated via electrocatalysis, and the sulfate free radicals and the hydroxyl free radicals are used for degrading pollutants in waste effectively.

The present invention relates to an antibiotic-polymer compound which can guarantee continuous release of antibiotics for several days under physiological conditions and can be used in human medicine and veterinary medicine. The antibiotic-polymer composite of the present invention is characterized in that one or more hydrophobic polymers selected from polymethacrylate, polyacrylate, methacrylate-acrylate copolymer and a One or more polymers selected from the homogeneous mixture of hydrophilic polymers such as polyethers are suspended in water containing one or more selected from aminoglycoside antibiotics, lincosamide antibiotics, tetracycline antibiotics, and quinolone antibiotics. A poorly soluble antibiotic, a water-soluble antibiotic optionally selected from the group consisting of aminoglycosides, lincosamides, β-lactams and tetracyclines, and an optional organic auxiliary material, and form the suspension into a complex.

The invention relates to a method for restoring antibiotics-polluted wastewater, which comprises the following steps: airing soil, then screening with a sieve of 15-30 meshes, and firing for 15-40 minutes at 400-600 DEG C to obtain a restorative agent; and feeding the restorative agent into the polluted wastewater with antibiotics, thus finishing the remediation within 5-10 hours. The method provided by the invention is efficient in removing antibiotics, especially tetracycline and quinolone from the polluted wastewater, with the removal rate up to 99.9% within 5 hours, capable of removing all the antibiotics within 6-10 hours. The restored water may meet relevant national standards for quality of water.