163 results about "Quinolone" patented technology

The invention provides a device and a method for detecting antibiotics in aquaculture water, and belongs to the technical field of environmental pollutant detection. According to the device disclosed by the invention, a Fe3O4 (at) GO magnetic nano adsorption material is packaged in a micro-fluidic chip reaction chamber, and a magnetic sticker is innovatively adopted to realize immobilization and replaceable design of an adsorbent; the integrated electromagnetic oscillation module drives the adsorbent to vibrate in the microchannel, and the mass transfer capture efficiency of antibiotics such as sulfonamides, quinolones and tetracyclines is remarkably improved. According to the method, an adsorption-elution-detection integrated process is initiated for the first time, the pretreatment time is shortened to be within 10 minutes from the hour level, synchronous detection of 0.01-5 [mu] g / L ultra-trace multi-component antibiotics in 5-10 [mu] L of a water sample is achieved, compared with a traditional method, the detection precision is remarkably improved, the matrix interference resistance is high, and the method is suitable for large-scale popularization and application. The method is suitable for real-time online monitoring of multiple antibiotic residues in the aquaculture environment.

The invention relates to a beta-cyclodextrin-based composite adsorption material with high selectivity as well as a preparation method and application of the beta-cyclodextrin-based composite adsorption material. The preparation method comprises the following steps: dissolving beta-cyclodextrin, an acrylamide monomer and a sodium p-styrenesulfonate monomer in water, and adjusting the pH value of the mixed solution to 6-8; adding an initiator into the obtained mixed solution, carrying out ultrasonic initiation polymerization reaction in an oxygen-free environment, and standing and curing overnight to obtain functional modified beta-cyclodextrin; dissolving the obtained functional modified beta-cyclodextrin, citric acid serving as a cross-linking agent and monopotassium phosphate serving as a catalyst in water, and heating for cross-linking reaction to obtain the beta-cyclodextrin-based composite adsorption material with high selectivity. Acrylamide and sodium p-styrenesulfonate monomers are grafted on beta-cyclodextrin through ultrasonic polymerization for chemical modification, then the characteristic that beta-cyclodextrin is easy to dissolve in water is changed through citric acid crosslinking, and the selective adsorption capacity of the obtained composite adsorption material to fluoroquinolone antibiotics is greatly enhanced.

The invention belongs to the field of antibiotic analysis and detection, and discloses a quinolone drug SERS (Surface Enhanced Raman Scattering) detection method based on an improved silver nano-substrate and a spectral angle matching model. An improved Lee-Meisel method is adopted to synthesize silver nano sol with precisely controlled particle size, molecular adsorption is realized by utilizing electrostatic interaction of a positively charged quinolone drug and negatively charged silver nano particles, and a high-density Raman enhanced hot spot is formed after an agglomeration agent is added; the SERS spectrum is collected at the excitation wavelength of 785 nm and the integral time of 10 s, qualitative distinguishing of drugs is achieved by combining a spectrum angle matching model, and quantitative detection is achieved by constructing a standard curve through the linear relation between the characteristic peak intensity and the drug concentration logarithm. The detection limit of the four drugs is as low as 1.03-1.16 ppb, the classification accuracy rate reaches 100%, the method is obviously superior to existing similar methods, the detection matrix range is wide, such as animal food and dairy products, and universality and high sensitivity are both considered.

The invention provides a compound as shown in a formula (I), and a stereoisomer, a tautomer, an isotope label, nitrogen oxide, a solvate, a polymorphic substance, a metabolite, ester, pharmaceutically acceptable salt or prodrug thereof, or a pharmaceutical composition thereof, which have better antibacterial and anti-inflammatory effects, can be used as an antibiotic, and can be used for preparing a pharmaceutical preparation for preventing and treating diseases. The compound can treat infection caused by pathogenic microorganisms resistant to erythromycin and telithromycin, and simultaneously acts on double targets of ribosome and topoisomerase.

This application discloses a linker and its preparation method. The linker includes pharmacophore P, pharmacophore Q, and deoxynucleotides and / or deoxynucleotide derivatives connecting pharmacophore P and pharmacophore Q. Pharmacophore P is obtained by removing the protecting group from group B, and pharmacophore Q is obtained by removing the protecting group from group X. Group B is obtained by chemically modifying the benzylquinolone carboxylic acid pharmacophore, and group X is obtained by chemically modifying the zenomeprazole pharmacophore. The linker is prepared by linking group B and group X with deoxynucleotides and / or deoxynucleotide derivatives to form the linker, including solid-phase synthesis technology. The method of this application can automatically synthesize molecular probes or bivalent drugs containing two pharmacophores, thereby replacing the traditional stepwise linking method, enabling efficient construction of screening libraries, and allowing control of the spatial distance and spatial orientation of the pharmacophores by adjusting the number and base arrangement of deoxynucleotides.

The invention discloses a multi-emission composite nano ratiometric fluorescent probe for detecting fluoroquinolone antibiotics and a preparation method of the multi-emission composite nano ratiometric fluorescent probe. The CdTe-Tb-UMP composite nano ratiometric fluorescent probe with double ligands is prepared by taking metal terbium ions (Tb < 3 + >) as central ions and respectively taking uridine monophosphate (UMP) and CdTe quantum dots with red fluorescence emission as bridged ligands. ENR is further coordinated with Tb < 3 + >, energy is transferred to Tb < 3 + > through an antenna effect, so that characteristic green fluorescence of Tb < 3 + > is turned on, and fluorescence of CdTe quantum dots is almost kept unchanged. On the basis, a portable nursing point testing system is further constructed, and the portable nursing point testing system comprises an intelligent mobile phone detector and a wearable fingertip sensor integrated with a micro-fluidic chip and is used for on-site rapid detection of the ENR. The paper-based chip shows rapid and sensitive fluorescence response, and the detection limits of the spectrograph and the paper-based sensor on the ENR are 4.7 nM and 13.1 nM respectively. The probe can be applied to detection of ENR in actual environment water samples, food and drugs.

The invention relates to the technical field of organic chemistry, and particularly discloses an amide derivative containing a thiazole oxime structure as shown in a general formula 8 and a preparation method and application of the amide derivative. The derivative shows remarkable antibacterial activity on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and fluoroquinolone-resistant escherichia coli, particularly has a remarkable effect on gram-negative bacteria, has broad-spectrum antibacterial potential and can be used for preparing drugs for treating related bacterial infection, and the activity of part of compounds is superior to that of a control drug.

The invention relates to the technical field of pesticide compounding, and discloses a bactericidal compound composition containing quinolone compounds and application thereof. The composition comprises effective active components, the effective active components comprise a compound I and a compound II, the compound I is 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid-2-methoxyethyl ester, and the compound II is other compounds with bacterial killing activity, and the compound I and the compound II are selected from the group consisting of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid-2-methoxyethyl ester and 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid-2-methoxyethyl ester. The bactericidal compound composition disclosed by the invention has the following advantages: (1) the bactericidal compound composition has a synergistic effect and can improve the prevention and treatment effect; (2) the bactericidal spectrum is expanded, field diseases are mixed, and the effect on bacterial diseases is stronger; (3) the two effective components are mixed for use, so that the drug resistance of pathogenic bacteria can be delayed; and (4) the application amount is reduced, the use frequency is reduced, and the use cost is reduced.

The invention discloses a passive sampling device and method for specifically enriching quinolones and tetracyclines antibiotics, and relates to water body detection. Firstly, a hydrogel thin film prepared from ZIF-C as an adsorbent is adopted as a binding film, ZIF-C particles are uniformly dispersed on the surface of the binding film, specific adsorption of quinolones and tetracyclines antibiotics can be achieved, then the binding film, a diffusion film and a polyether sulfone filtering film are sequentially stacked to be assembled into an o-DGT device, o-DGT is put into a water body, and through diffusion and adsorption, the specific adsorption of the quinolones and tetracyclines antibiotics can be achieved. The method realizes the extraction and detection of quinolone and tetracycline antibiotics by the DGT technology.

The invention relates to the field of microorganisms and water treatment, and discloses pseudomonas capable of degrading fluoroquinolone antibiotics, a complex microbial inoculant and application of the pseudomonas and the complex microbial inoculant. The pseudomonas is named as 11-10, the preservation number is CGMCC No.33680, the microorganism classification is named as pseudomonas sp., the preservation unit is China General Microbiological Culture Collection Center, the preservation date is February 28, 2025, and the preservation number is CGMCC No.33680, the microorganism classification is named as Pseudomonas sp., the preservation unit is China General Microbiological Culture Collection Center, and the preservation date is February 28, 2025. Firstly, the new pseudomonas strain obtained through screening has high tolerance to the fluoroquinolone antibiotics and can efficiently degrade the fluoroquinolone antibiotics; and secondly, in the composite microbial agent disclosed by the invention, the new pseudomonas species, the bacillus tequilensis and the paenibacillus deserticola can play a relatively good synergistic effect, so that the endurance capacity and the degradation capacity on the fluoroquinolone antibiotic wastewater can be further improved.

The application relates to quinolone aminothiadiazole compounds, a preparation method and medical applications thereof, and belongs to the technical field of chemical synthesis. The quinolone aminothiadiazole compounds are shown in a general formula I. The compounds have good inhibitory activity on one or more of gram-positive bacteria, gram-negative bacteria and fungi, can be used for preparing antibacterial and / or antifungal drugs, have no obvious drug resistance, and can provide more efficient and safe candidate drugs for clinical anti-infection treatment.

The invention relates to the technical field of microorganisms, in particular to lactobacillus paracasei ZK-35 and application thereof. The lactobacillus paracasei ZK-35 is separated from a human oral cavity flushing fluid, has good compatibility with the human intestinal environment, high safety and excellent acid and cholate resistance, has an effect of relieving side effects of various antibiotics such as penicillin, cephalosporin and quinolones, can regulate various intestinal florae at the same time, improves constipation and diarrhea, and has a good application prospect in the field of oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid and oral cavity flushing fluid. The intestinal barrier function is enhanced, and nutrient absorption is promoted.

The present invention provides methods, compositions, and combinations for treating cancer via combined use of a compound of formula I or a pharmaceutically acceptable salt, ester, solvate and / or prodrug thereof, wherein A, Q, n, m, R7, R8, V, X1, X2, X3, X4, X5, X6, and X7 are as defined herein, and at least one therapeutically active agents selected from immunotherapeutics, anticancer agents, and anti-angiogenics.

The present invention relates to stable synergistic insecticidal composition for synergistic and effective control of various insect pests including entire sucking pests complex. The present invention also relates to a process for preparation thereof.

Provided are a quinolone analogue represented by formula (I), or a pharmaceutically acceptable salt, a stereoisomer, a racemate, a deuterated compound, or a solvent compound and a pharmaceutical composition thereof, and uses thereof in the preparation of drugs for treating tumors, autoimmune diseases, or diseases caused by bacteria, fungi or viruses.

The application discloses a kind of iron monatomic catalysts with high efficiency in degrading fluoroquinolone antibiotics and defluorination and application thereof.The application realizes controllable preparation of iron monatomic catalysts with different sulfur coordination by changing the complexation between sulfur-containing ligand and iron ion.The removal of high-energy carbon-fluorine bond is the key and difficulty of fluoroquinolone antibiotic degradation, and the regulation of iron electron-rich region / sulfur electron-deficient region can promote the efficient occurrence of electron transfer process, which is beneficial to the rupture of carbon-fluorine bond.The iron monatomic catalyst prepared by the method has good degradation effect and defluorination efficiency for various fluoroquinolone antibiotics.

The present invention discloses a quinolone compound, its preparation method, and use, belonging to the field of pharmaceutical technology. The present invention provides a novel quinolone compound, including pharmaceutically acceptable salts, hydrates, solvates, polycrystals, or cocrystals thereof, as well as pharmaceutical prodrugs or derivatives thereof. The provided quinolone compound and its derivatives can be used to prepare drugs for treating bacterial infections. The compounds exhibit significant anti-MRSA activity and lack cross-resistance with existing fluoroquinolones.

The present application relates to a kind of metal single atom and nanoparticle composite catalyst and its preparation method.By the reasonable proportioning of metal salt, dicyanediamine and urea dosage, high loading single atom and nanoparticle composite catalyst is prepared by simple two-step pyrolysis method, the preparation method is simple, metal loading can be controlled, with good reproducibility and applicable to a variety of metal salt (such as Co, Cu, Ni, Fe, Mn, etc.).Single atom and nanoparticle composite catalyst obtained by the present application can construct a large number of active sites, significantly improve the catalytic activity and stability of catalyst, for degrading sulfonamide organic pollutants, quinolone organic pollutants and tetracycline organic pollutants, or for depolymerization lignin, all of which show excellent catalytic activity, and the degradation or depolymerization effect is higher than that of currently reported catalyst.

The invention relates to a quinolone compound, in particular to a quinolone compound as well as a preparation method and application thereof. The method comprises the following steps: dissolving a compound I (1, 8-naphthyridine-4-alcohol) in a mixed solution of DMSO and water, adding potassium carbonate and a compound II (3, 5-difluoropyridine), and heating for reaction to obtain a compound III; the invention provides a brand new synthesis method of quinolone compounds, by screening a solvent and alkali, a nitrogen atom at a site 1 of a compound I can be subjected to nucleophilic substitution with fluorine of a compound II, so that side reaction participated by hydroxyl at a site 4 of the compound I is avoided, and a compound III is efficiently prepared. In addition, the compound III has a remarkable inhibition effect on tumor cells and can be used for preparing anti-cancer drugs.

The invention discloses a magnetic nano-material and application thereof in extraction of fluoroquinolone compounds, and the magnetic nano-material is prepared by mixing an aqueous solution of Fe3O4 (at) SiO2 microspheres with NH2 modified surfaces and an ethanol aqueous solution of fluorinated graphene according to a volume ratio of (2-4): (1-3) and then stirring. The magnetic nano material is used as a magnetic solid-phase extraction adsorbent and can be used for extracting fluoroquinolone compounds in a sample. The magnetic nano material disclosed by the invention not only can efficiently extract various fluoroquinolone compounds in simple matrixes such as water, milk and the like, but also can directly enrich and extract various fluoroquinolone compounds in complex matrixes such as cosmetics and the like without tedious and time-consuming purification steps; and high-throughput detection of various trace fluoroquinolone compounds in a sample can be realized.

Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and / or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.

The present application belongs to the technical field of quorum quenching enzyme preparation, and particularly relates to a multi-target quorum quenching enzyme preparation and a preparation method and application thereof, such as being mainly used for inhibiting the virulence factors of Pseudomonas aeruginosa, and including acyl homoserine lactone acyltransferase AiiO protein and 3-hydroxy-4-oxoquinolone 2,4-dioxygenase AqdC protein, and the mass ratio of the two is 20:(1-25); such as being mainly used for inhibiting the virulence factors and the synthesis of biological membranes of Pseudomonas aeruginosa, and further including deferiprone, and the mass ratio of AiiO, AqdC and deferiprone is 20:(1-25):(0.695-2.78), the present application can target the Las, Rhl and PQS of Pseudomonas aeruginosa, the yield and stability of the prepared AqdC protein are both high, the two types of enzymes are used in combination after the regulation amount, and the virulence factors regulated by different quorum sensing pathways in Pseudomonas aeruginosa are effectively inhibited; the regulation amount of deferiprone is used in combination with the two types of quorum quenching enzymes, and the virulence and biological membranes of Pseudomonas aeruginosa can be effectively inhibited in a comprehensive manner.

The application discloses a method for simultaneously detecting 32 kinds of veterinary drug residues in fecal pollution, and belongs to the technical field of veterinary drug residue detection. The method comprises the following steps: taking a fecal pollution sample, adding Na2EDTA-Mcllvaine buffer solution and acetonitrile for extraction, centrifuging the sample after salting-out to obtain an organic phase, purifying the organic phase through an LPAS purification column, collecting the purified liquid, concentrating and blowing dry, redissolving, filtering, and obtaining a to-be-detected liquid; detecting the to-be-detected liquid by using an ultra-high performance liquid chromatography-triple quadrupole mass spectrometer, gradient elution; and quantitatively detecting 32 kinds of veterinary drugs by using a matrix matching standard curve method. The method is simple in operation and good in purification effect, can effectively remove interfering substances such as fat and protein in the fecal pollution, significantly reduces the matrix effect, is suitable for simultaneously, quickly and accurately detecting 23 kinds of sulfonamides and 9 kinds of fluoroquinolones in pig, chicken, cow and duck fecal pollution, and has good accuracy and precision.

The invention relates to quinoxaline derivatives as anti-cancer drugs. Specifically, the invention relates to azaquinolone compounds of formula (I) and their use in medicine.

The application belongs to the technical field of photocatalytic materials and the field of environmental governance, and discloses a preparation method and application of a heterojunction photocatalytic material for degrading fluoroquinolone antibiotics. The catalytic material is an S-type photocatalytic material, and the heterojunction photocatalytic material can be prepared through a simple hydrothermal method. By controlling the addition amount of NH2-MIL-68(In), Bi2MoO6 / NH2-MIL-68(In) heterojunctions with different component contents are obtained. Experimental results show that when the Bi2MoO6 / NH2-MIL-68(In) (BMN-2) photocatalytic material prepared by the application is applied to photocatalytic degradation of ofloxacin in water, 100% of the ofloxacin can be degraded after visible light irradiation for 90 minutes. In addition, the photocatalyst also has good photocatalytic degradation performance for ofloxacin in actual water. The heterojunction photocatalyst prepared by the application has good visible light response and excellent antibiotic degradation performance, and has good application prospect in the field of photocatalytic degradation of antibiotics.

The application belongs to the field of biological medicine and health, and discloses a preparation method of a novel tricyclic indole pyridone carboxylic quinolone molecule. The method is based on the fact that only one N atom is inserted into the bicyclic quinoline nucleus of the pharmacodynamic skeleton "quinoline-4-ketone-3-carboxylic acid" of fluoroquinolone drugs, and then a novel tricyclic indole pyridone carboxylic fluoroquinolone drug molecule is ingeniously constructed, a new structure antibacterial lead compound is found through in-vitro activity evaluation, and a basis is provided for the creation of a new drug with independent intellectual property rights to overcome the drug resistance and adverse reactions of existing drugs.

Provided herein are pharmaceutical compositions comprising a quinolone compound for irritable bowel syndrome, especially provided is the use of the quinolone compound, in particular 1-cyclopropyl-6-fluoro-1, 4-dihydro-8-methyl-7- (2-amino-3-cyano-5-pyridyl) -4-oxo-3-quinoline-carboxylic acid or a pharmacologically acceptable salt, a hydrate, a solvate or a deuteride thereof for preventing or treating irritable bowel syndrome of a human or an animal.

The invention relates to the technical field of chemical synthesis of medicines, in particular to a pleuromutilin derivative, a preparation method thereof and an antibacterial active composition. The invention relates to a pleuromutilin derivative with a structure as shown in a formula I, or pharmaceutically and / or veterinary acceptable salt, a solvent compound, an optical isomer and a polymorphic compound of the pleuromutilin derivative. Formula I; wherein R1 is selected from one of a hydrogen atom and methyl; r2 is selected from one of a hydrogen atom and a methoxy group; and R3 is selected from one of cyclopropyl and p-fluorophenyl. According to the present invention, the quinolone drug is spliced to the pleuromutilin side chain to produce the new pleuromutilin derivative, and the obtained new compound can enhance the antibacterial activity, has significant antibacterial activity on Gram-positive bacteria and Gram-negative bacteria, and further has significant inhibition effect on MRSA and other drug-resistant bacteria so as to effectively broaden the antibacterial spectrum.